Cancer Research A JournalA Journal of ofthe the American American Association Association for for Cancer Cancer Research Research

Volume 69 • Number 7 April 1, 2009 • Pages 2695–3240

Spleen Tyrosine Kinase Functions as a Tumor Suppressor in Reviews Melanoma Cells by Inducing Senescence-like Growth Arrest. Olivier Bailet, Nina Fenouille, Patricia Abbe, Guillaume Robert, Coordinates in the Universe of Node-Negative Breast Cancer Revisited. Stéphane Rocchi, Nadège Gonthier, Christophe Denoyelle, Marcus Schmidt, Jan G. Hengstler, Christian von Törne, Heinz Koelbl, Michel Ticchioni, Jean-Paul Ortonne, Robert Ballotti, Marcel Deckert, and Mathias C. Gehrmann...... 2695 and Sophie Tartare-Deckert...... 2748 Potential Stages for Prostate Cancer Prevention with Selenium: Implications for Cancer Survivors. Nicole Facompre and TW-37, a Small-Molecule Inhibitor of Bcl-2, Inhibits Cell Growth Karam El-Bayoumy ...... 2699 and Induces Apoptosis in Pancreatic Cancer: Involvement of Notch-1 Signaling Pathway. Zhiwei Wang, Asfar Sohail Azmi, Aamir Ahmad, Sanjeev Banerjee, Shaomeng Wang, Fazlul H. Sarkar, Priority Reports and Ramzi M. Mohammad ...... 2757

In vivo Imaging of Cutaneous T-Cell Lymphoma Migration to the Skin. Activation of DNA Methyltransferase 1 by EBV Latent Membrane Christoph Hoeller, Stephen K. Richardson, Lai Guan Ng, Teresa Valero, Protein 2A Leads to Promoter Hypermethylation of PTEN Gene in Maria Wysocka, Alain H. Rook, and Wolfgang Weninger...... 2704 Gastric Carcinoma. Rumi Hino, Hiroshi Uozaki, Noriko Murakami, Noninvasive De novo Imaging of Human Embryonic Stem Cell–Derived Tetsuo Ushiku, Aya Shinozaki, Shumpei Ishikawa, Teppei Morikawa, Teratoma Formation. Feng Cao, Zibo Li, Andrew Lee, Zhaofei Liu, Takeo Nakaya, Takashi Sakatani, Kenzo Takada, Kai Chen, Hui Wang, Weibo Cai, Xiaoyuan Chen, and Joseph C. Wu...... 2709 and Masashi Fukayama ...... 2766

Real-time Study of E-Cadherin and Membrane Dynamics in Living Central Role of c-Myc during Malignant Conversion in Human Animals: Implications for Disease Modeling and Drug Development. Hepatocarcinogenesis. Pal Kaposi-Novak, Louis Libbrecht, Alan Serrels, Paul Timpson, Marta Canel, Juliane P. Schwarz, Hyun Goo Woo, Yun-Han Lee, Nathaniel C. Sears, Elizabeth A. Conner, Neil O. Carragher, Margaret C. Frame, Valerie G. Brunton, Valentina M. Factor, Tania Roskams, and Snorri S. Thorgeirsson ...... 2775 and Kurt I. Anderson...... 2714 A Novel Prostate Cancer Susceptibility Locus at 19q13. Fang-Chi Hsu, Thyroid Transcription Factor-1 Inhibits Transforming Growth Jielin Sun, Fredrik Wiklund, Sarah D. Isaacs, Kathleen E. Wiley, Factor-␤–Mediated Epithelial-to-Mesenchymal Transition in Lung Lina D. Purcell, Zhengrong Gao, Pär Stattin, Yi Zhu, Seong-Tae Kim, Adenocarcinoma Cells. Roy-Akira Saito, Tetsuro Watabe, Zheng Zhang, Wennuan Liu, Bao-Li Chang, Patrick C. Walsh, David Duggan, Kana Horiguchi, Tadashi Kohyama, Masao Saitoh, Takahide Nagase, John D. Carpten, William B. Isaacs, Henrik Grönberg, Jianfeng Xu, and Kohei Miyazono ...... 2783 and S. Lilly Zheng ...... 2720 Diaphanous-Related Formins Are Required for Invadopodia Formation A Breast Cancer Risk Haplotype in the Caspase-8 Gene. and Invasion of Breast Tumor Cells. Floria Lizárraga, Renaud Poincloux, Neil Duncan Shephard, Ryan Abo, Sushila Harkisandas Rigas, Maryse Romao, Guillaume Montagnac, Gaëlle Le Dez, Isabelle Bonne, Bernd Frank, Wei-Yu Lin, Ian Wallace Brock, Adam Shippen, Guillem Rigaill, Graça Raposo, and Philippe Chavrier...... 2792 Sabapathy Prakash Balasubramanian, Malcolm Walter Ronald Reed, Claus Rainer Bartram, Alfons Meindl, Rita Katharina Schmutzler, Endothelial Nitric Oxide Synthase Mediates Lymphangiogenesis and Christoph Engel, Barbara Burwinkel, Lisa Anne Cannon-Albright, Lymphatic Metastasis. Johanna Lahdenranta, Jeroen Hagendoorn, Kristina Allen-Brady, Nicola Jane Camp, and Angela Cox ...... 2724 Timothy P. Padera, Tohru Hoshida, Gregory Nelson, Satoshi Kashiwagi, Induction of Prostaglandin E2 Pathway Promotes Gastric Hamartoma Rakesh K. Jain, and Dai Fukumura ...... 2801 Development with Suppression of Bone Morphogenetic Protein Signaling. Hiroko Oshima, Hiraku Itadani, Hidehito Kotani, The Receptor Interacting Protein 1 Inhibits p53 Induction through Makoto Mark Taketo, and Masanobu Oshima...... 2729 NF-␬B Activation and Confers a Worse Prognosis in Glioblastoma. Seongmi Park, Kimmo J. Hatanpaa, Yang Xie, Bruce E. Mickey, SLC45A3-ELK4 Is a Novel and Frequent Erythroblast Christopher J. Madden, Jack M. Raisanen, Deepti B. Ramnarain, Transformation–Specific Fusion Transcript in Prostate Cancer. Guanghua Xiao, Debabrata Saha, David A. Boothman, Dawen Zhao, David S. Rickman, Dorothee Pflueger, Benjamin Moss, Vanessa E. VanDoren, Robert M. Bachoo, Russell O. Pieper, and Amyn A. Habib ...... 2809 Chen X. Chen, Alexandre de la Taille, Rainer Kuefer, Ashutosh K. Tewari, Sunita R. Setlur, Francesca Demichelis, and Mark A. Rubin ...... 2734 Altered Subcellular Localization of Tumor-Specific Cyclin E Isoforms Affects Cyclin-Dependent Kinase 2 Complex Formation and Cell, Tumor, and Stem Cell Biology Proteasomal Regulation. Nikki A. Delk, Kelly K. Hunt, and Khandan Keyomarsi ...... 2817 Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant GPR109A Is a G-protein–Coupled Receptor for the Bacterial Tumor Formation. Craig D. Simpson, Imtiaz A. Mawji, Kika Anyiwe, Fermentation Product Butyrate and Functions as a Tumor Moyo A. Williams, Xiaoming Wang, Amudha L. Venugopal, Suppressor in Colon. Muthusamy Thangaraju, Gail A. Cresci, Kebin Liu, Marcela Gronda, Rose Hurren, Sonia Cheng, Stefano Serra, Sudha Ananth, Jaya P. Gnanaprakasam, Darren D. Browning, Reza Beheshti Zavareh, Alessandro Datti, Jeffrey L. Wrana, John D. Mellinger, Sylvia B. Smith, Gregory J. Digby, Nevin A. Lambert, Shereen Ezzat, and Aaron D. Schimmer...... 2739 Puttur D. Prasad, and Vadivel Ganapathy ...... 2826

Downloaded from cancerres.aacrjournals.org on September 23, 2021. © 2009 American Association for Cancer Research. Contents (Continued) MUC1-Induced Transcriptional Programs Associated with Quantitative Optical Spectroscopy: A Robust Tool for Direct Tumorigenesis Predict Outcome in Breast and Lung Cancer. Measurement of Breast Cancer Vascular Oxygenation and Total Nikolai N. Khodarev, Sean P. Pitroda, Michael A. Beckett, Hemoglobin Content In vivo. J. Quincy Brown, Lee G. Wilke, Dhara M. MacDermed, Lei Huang, Donald W. Kufe, Joseph Geradts, Stephanie A. Kennedy, Gregory M. Palmer, and Ralph R. Weichselbaum...... 2833 and Nirmala Ramanujam...... 2919

Rho GDP Dissociation Inhibitor 2 Suppresses Metastasis via In situ Unconventional Regulation of RhoGTPases. Konstadinos Moissoglu, Expression of Tumor Antigens by Messenger Kevin S. McRoberts, Jeremy A. Meier, Dan Theodorescu, RNA–Electroporated Dendritic Cells in Lymph Nodes of Melanoma and Martin A. Schwartz...... 2838 Patients. Danita H. Schuurhuis, Pauline Verdijk, Gerty Schreibelt, Erik H.J.G. Aarntzen, Nicole Scharenborg, Annemiek de Boer, The Membrane Mucin Muc4 Inhibits Apoptosis Induced by Multiple Mandy W.M.M. van de Rakt, Marieke Kerkhoff, Marie-Jeanne P. Gerritsen, Insults via ErbB2-Dependent and ErbB2-Independent Mechanisms. Femke Eijckeler, Johannes J. Bonenkamp, Willeke Blokx, Heather C. Workman, Colleen Sweeney, and Kermit L. Carraway III....2845 J. Han van Krieken, Otto C. Boerman, Wim J.G. Oyen, Cornelis J.A. Punt, Carl G. Figdor, Gosse J. Adema, and I. Jolanda M. de Vries ...... 2927 Angiotensinogen Delays Angiogenesis and Tumor Growth of Hepatocarcinoma in Transgenic Mice. François Vincent, Philippe Bonnin, Maud Clemessy, Jean-Olivier Contrerès, Noël Lamandè, Endocrinology Jean-Marie Gasc, Josè Vilar, Patricia Hainaud, Gèrard Tobelem, Pierre Corvol, and Evelyne Dupuy...... 2853 Association of Estrogen Receptor ␣ and Histone Deacetylase 6 Causes Rapid Deacetylation of Tubulin in Breast Cancer Cells. Kotaro Azuma, The Human Cytomegalovirus–Encoded Chemokine Receptor US28 Tomohiko Urano, Kuniko Horie-Inoue, Shin-ichi Hayashi, Ryuichi Sakai, Promotes Angiogenesis and Tumor Formation via Cyclooxygenase-2. Yasuyoshi Ouchi, and Satoshi Inoue...... 2935 David Maussang, Ellen Langemeijer, Carlos P. Fitzsimons, Marijke Stigter-van Walsum, Remco Dijkman, Martin K. Borg, Erik Slinger, Andreas Schreiber, Detlef Michel, Cornelis P. Tensen, Androgen Receptor Controls EGFR and ERBB2 Gene Expression at Guus A.M.S. van Dongen, Rob Leurs, and Martine J. Smit...... 2861 Different Levels in Prostate Cancer Cell Lines. Jean-Christophe Pignon, Benjamin Koopmansch, Gregory Nolens, Laurence Delacroix, PME-1 Protects Extracellular Signal-Regulated Kinase Pathway David Waltregny, and Rosita Winkler ...... 2941 Activity from Protein Phosphatase 2A–Mediated Inactivation in Human Malignant Glioma. Pietri Puustinen, Melissa R. Junttila, Sari Vanhatupa, Anna A. Sablina, Melissa E. Hector, Kaisa Teittinen. Epidemiology Olayinka Raheem, Kirsi Ketola, Shujun Lin, Juergen Kast, Hannu Haapasalo, William C. Hahn, and Jukka Westermarck...... 2870 Associations between Selected Biomarkers and Prognosis in a Population-Based Pancreatic Cancer Tissue Microarray. Caveolin-1 Regulates the Antagonistic Pleiotropic Properties of Mikiko Takikita, Sean Altekruse, Charles F. Lynch, Mark T. Goodman, Cellular Senescence through a Novel Mdm2/p53-Mediated Pathway. Brenda Y. Hernandez, Mark Green, Wendy Cozen, Myles Cockburn, Janine N. Bartholomew, Daniela Volonte, and Ferruccio Galbiati ...... 2878 Maria Sibug Saber, Marie Topor, Chris Zeruto, Behnoush Abedi-Ardekani, Immune-Induced Epithelial to Mesenchymal Transition In vivo Marsha E. Reichman, and Stephen M. Hewitt ...... 2950 Generates Breast Cancer Stem Cells. Marta Santisteban, Jennifer M. Reiman, Michael K. Asiedu, Marshall D. Behrens, Aziza Nassar, Genetic Associations of 115 Polymorphisms with Cancers of the Kimberly R. Kalli, Paul Haluska, James N. Ingle, Lynn C. Hartmann, Upper Aerodigestive Tract across 10 European Countries: The Masoud H. Manjili, Derek C. Radisky, Soldano Ferrone, ARCAGE Project. Cristina Canova, Mia Hashibe, Lorenzo Simonato, and Keith L. Knutson...... 2887 Mari Nelis, Andres Metspalu, Pagona Lagiou, Dimitrios Trichopoulos, Wolfgang Ahrens, Iris Pigeot, Franco Merletti, Lorenzo Richiardi, Telomere Length in Peripheral Blood Predicts Survival in Clear Renato Talamini, Luigi Barzan, Gary J. Macfarlane, Tatiana V. Macfarlane, Cell Renal Cell Carcinoma. Ulrika Svenson, Börje Ljungberg, Ivana Holcátová, Vladimir Bencko, Simone Benhamou, and Göran Roos...... 2896 Christine Bouchardy, Kristina Kjaerheim, Ray Lowry, Antonio Agudo, Xavier Castellsagué, David I. Conway, Patricia A. McKinney, Ariana Znaor, Credentialing a Preclinical Mouse Model of Alveolar Bernard E. McCartan, Claire M. Healy, Manuela Marron, Rhabdomyosarcoma. Koichi Nishijo, Qing-Rong Chen, Lei Zhang, and Paul Brennan...... 2956 Amanda T. McCleish, Andrea Rodriguez, Min Jung Cho, Suresh I. Prajapati, Jonathan A.L. Gelfond, Gary B. Chisholm, Joel E. Michalek, Bruce J. Aronow, Frederic G. Barr, R. Lor Randall, Marc Ladanyi, Plasma Protein Carbonyls and Breast Cancer Risk in Sisters Stephen J. Qualman, Brian P. Rubin, Robin D. LeGallo, Chiayeng Wang, Discordant for Breast Cancer from the New York Site of the Breast Javed Khan, and Charles Keller...... 2902 Cancer Family Registry. Jennifer Zipprich, Mary Beth Terry, Yuyan Liao, Meenakshi Agrawal, Irina Gurvich, Ruby Senie, and Regina M. Santella ...... 2966 Clinical Research

Characterization of ERG, AR, and PTEN Gene Status in Circulating Association between Chronic Atrophic Gastritis and Serum Helicobacter pylori Tumor Cells from Patients with Castration-Resistant Prostate Cancer. Antibodies to 15 Proteins Measured by Multiplex Gerhardt Attard, Joost F. Swennenhuis, David Olmos, Alison H.M. Reid, Serology. Lei Gao, Melanie N. Weck, Angelika Michel, Michael Pawlita, Elaine Vickers, Roger A’Hern, Rianne Levink, Frank Coumans, and Hermann Brenner ...... 2973 Joana Moreira, Ruth Riisnaes, Nikhil Babu Oommen, George Hawche, Charles Jameson, Emilda Thompson, Ronald Sipkema, Craig P. Carden, Characterization of UGTs Active against SAHA and Association Christopher Parker, David Dearnaley, Stan B. Kaye, Colin S. Cooper, between SAHA Glucuronidation Activity Phenotype with UGT Arturo Molina, Michael E. Cox, Leon W.M.M. Terstappen, Genotype. Renee M. Balliet, Gang Chen, Carla J. Gallagher, and Johann S. de Bono...... 2912 Ryan W. Dellinger, Dongxiao Sun, and Philip Lazarus...... 2981

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Urinary Levels of Tobacco-Specific Nitrosamine Metabolites in Chemokine Expression in Melanoma Metastases Associated with Relation to Lung Cancer Development in Two Prospective Cohorts of CD8+ T-Cell Recruitment. Helena Harlin, Yuru Meng, Amy C. Peterson, Cigarette Smokers. Jian-Min Yuan, Woon-Puay Koh, Sharon E. Murphy, Yuanyuan Zha, Maria Tretiakova, Craig Slingluff, Mark McKee, Yunhua Fan, Renwei Wang, Steven G. Carmella, Shaomei Han, and Thomas F. Gajewski ...... 3077 Katie Wickham, Yu-Tang Gao, Mimi C. Yu, and Stephen S. Hecht...... 2990 Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via L-Arginine Metabolism. Lyse A. Norian, Paulo C. Rodriguez, Experimental Therapeutics, Molecular Targets, Leigh A. O’Mara, Jovanny Zabaleta, Augusto C. Ochoa, Marina Cella, and Chemical Biology and Paul M. Allen...... 3086 GD3, an Overexpressed Tumor-Derived Ganglioside, Mediates the Hyperactivation of the Insulin-like Growth Factor Receptor I Apoptosis of Activated but not Resting T Cells. Gaurisankar Sa, Signaling Pathway Is an Essential Event for Cisplatin Resistance of Tanya Das, Christina Moon, Cynthia M. Hilston, Patricia A. Rayman, Ovarian Cancer Cells. Niels Eckstein, Kati Servan, Barbara Hildebrandt, Brian I. Rini, Charles S. Tannenbaum, and James H. Finke ...... 3095 Anne Pölitz, Georg von Jonquières, Sybille Wolf-Kümmeth, Inge Napierski, Triggering of Toll-like Receptor 4 Expressed on Human Head and Alexandra Hamacher, Matthias U. Kassack, Jan Budczies, Manfred Beier, Neck Squamous Cell Carcinoma Promotes Tumor Development and Manfred Dietel, Brigitte Royer-Pokora, Carsten Denkert, Protects the Tumor from Immune Attack. Miroslaw J. Szczepanski, and Hans-Dieter Royer ...... 2996 Malgorzata Czystowska, Marta Szajnik, Malgorzata Harasymczuk, Depletion of Guanine Nucleotides Leads to the Mdm2-Dependent Michael Boyiadzis, Aleksandra Kruk-Zagajewska, Witold Szyfter, Proteasomal Degradation of Nucleostemin. Min Huang, Koji Itahana, Jan Zeromski, and Theresa L. Whiteside...... 3105 Yanping Zhang, and Beverly S. Mitchell...... 3004 CTL Activation Using the Natural Low-Affinity Epitope 222-229 from Tyrosinase-Related Protein 1 Leads to Tumor Rejection. Modulation of Caspase-Independent Cell Death Leads to Kevin D. Pavelko, Michael J. Hansen, and Larry R. Pease...... 3114 Resensitization of Imatinib Mesylate–Resistant Cells. Vanessa J. Lavallard, Ludivine A. Pradelli, Audrey Paul, Marie Bénéteau, Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Arnaud Jacquel, Patrick Auberger, and Jean-Ehrland Ricci ...... 3013 Impaired Migration to Lymph Nodes and Bone Marrow. Tanja Nicole Hartmann, Valentin Grabovsky, Wei Wang, Petra Desch, The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Gabriele Rubenzer, Stefan Wollner, Inbal Binsky, Target for Head and Neck Squamous Cell Carcinoma. Alexandra Vallon-Eberhard, Anita Sapoznikov, Meike Burger, Tanguy Y. Seiwert, Ramasamy Jagadeeswaran, Leonardo Faoro, Idit Shachar, Michal Haran, Marek Honczarenko, Richard Greil, Varalakshmi Janamanchi, Vidya Nallasura, Mohamed El Dinali, Soheil Yala, and Ronen Alon ...... 3121 Rajani Kanteti, Ezra E.W. Cohen, Mark W. Lingen, Leslie Martin, Soundararajan Krishnaswamy, Andres Klein-Szanto, James G. Christensen, Everett E. Vokes, and Ravi Salgia...... 3021 Molecular Biology, Pathobiology, and Genetics

FMS-Like Tyrosine Kinase 3–Internal Tandem Duplication Tyrosine Human ZNF312b Promotes the Progression of Gastric Cancer by Kinase Inhibitors Display a Nonoverlapping Profile of Resistance Transcriptional Activation of the K-ras Gene. In-Sung Song, Nang Su Oh, Mutations In vitro. Nikolas von Bubnoff, Richard Engh, Espen Åberg, Hyun-Taek Kim, Ga-Hee Ha, So-Young Jeong, Jeong-Min Kim, Dong-Il Kim, Jana Sänger, Christian Peschel, and Justus Duyster ...... 3032 Hyang-Sook Yoo, Cheol-Hee Kim, and Nam-Soon Kim...... 3131

Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted Genome-Wide Impact of Androgen Receptor Trapped clone-27 Loss by BRAFV600E Mutational Status and Sustained Extracellular on Androgen-Regulated Transcription in Prostate Cancer Cells. Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Jerome C. Nwachukwu, Paolo Mita, Rachel Ruoff, Susan Ha, Suppression. Klaus P. Hoeflich, Sylvia Herter, Janet Tien, Leo Wong, Qianben Wang, S. Joseph Huang, Samir S. Taneja, Myles Brown, Leanne Berry, Jocelyn Chan, Carol O’Brien, Zora Modrusan, William L. Gerald, Michael J. Garabedian, and Susan K. Logan ...... 3140 Somasekar Seshagiri, Mark Lackner, Howard Stern, Edna Choo, Programmed Cell Death Protein 4 Down-regulates Y-Box Binding Lesley Murray, Lori S. Friedman, and Marcia Belvin ...... 3042 Protein-1 Expression via a Direct Interaction with Twist1 to Suppress Cancer Cell Growth. Masaki Shiota, Hiroto Izumi, N Dose-Response Relationships for 7-(2-Hydroxyethyl)Guanine Akihide Tanimoto, Mayu Takahashi, Naoya Miyamoto, Eiji Kashiwagi, 14 Induced by Low-Dose [ C]Ethylene Oxide: Evidence for a Novel Akihiko Kidani, Gen Hirano, Daisuke Masubuchi, Yasushi Fukunaka, Mechanism of Endogenous Adduct Formation. Debbie A. Marsden, Yoshihiro Yasuniwa, Seiji Naito, Shigeru Nishizawa, Yasuyuki Sasaguri, Donald J.L. Jones, Robert G. Britton, Ted Ognibene, Esther Ubick, and Kimitoshi Kohno ...... 3148 George E. Johnson, Peter B. Farmer, and Karen Brown ...... 3052 A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Bladder Cancer Progression. Keiji Shimada, Mitsutoshi Nakamura, Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Satoshi Anai, Marco De Velasco, Motoyoshi Tanaka, Kazutake Tsujikawa, Lymphoblastic Leukemia Cells. Sudhir S. Rao, Jennifer O’Neil, Yukiteru Ouji, and Noboru Konishi...... 3157 Cole D. Liberator, James S. Hardwick, Xudong Dai, Theresa Zhang, Impaired Turnover of Prolactin Receptor Contributes to Edyta Tyminski, Jing Yuan, Nancy E. Kohl, Victoria M. Richon, Transformation of Human Breast Cells. Alexandr Plotnikov, Lex H.T. Van der Ploeg, Pamela M. Carroll, Giulio F. Draetta, Bentley Varghese, Thai H. Tran, Chengbao Liu, Hallgeir Rui, A. Thomas Look, Peter R. Strack, and Christopher G. Winter ...... 3060 and Serge Y. Fuchs ...... 3165

Immunology Systems Biology and Emerging Technologies

A Key Regulatory Role of the Transcription Factor NFATc2 in Noninvasive Imaging of ␣V␤3 Function as a Predictor of the .Bronchial Adenocarcinoma via CD8؉ T Lymphocytes. Antimigratory and Antiproliferative Effects of Dasatinib Joachim H. Maxeiner, Roman Karwot, Kerstin Sauer, Petra Scholtes, Rebecca A. Dumont, Isabel Hildebrandt, Helen Su, Roland Haubner, Ildiko Boross, Michael Koslowski, Özlem Türeci, Rainer Wiewrodt, Gerald Reischl, Johannes G. Czernin, Paul S. Mischel, Markus F. Neurath, Hans A. Lehr, and Susetta Finotto ...... 3069 and Wolfgang A. Weber ...... 3173

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Magnetovaccination as a Novel Method to Assess and Quantify The EGF/CSF-1 Paracrine Invasion Loop Can Be Triggered by Dendritic Cell Tumor Antigen Capture and Delivery to Lymph Nodes. Heregulin ␤1 and CXCL12. Lorena Hernandez, Tatiana Smirnova, Christopher M. Long, Hanneke W.M. van Laarhoven, Jeff W.M. Bulte, Dmitriy Kedrin, Jeffrey Wyckoff, Liyin Zhu, E. Richard Stanley, Dianne Cox, and Hyam I. Levitsky...... 3180 William J. Muller, Jeffrey W. Pollard, Nico Van Rooijen, and Jeffrey E. Segall...... 3221 Tumor Microenvironment Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase. Cathepsin G Recruits Osteoclast Precursors via Proteolytic Activation Hélène Maby-El Hajjami, Patricia Amé-Thomas, Céline Pangault, of Protease-Activated Receptor-1. Thomas J. Wilson, Kalyan C. Nannuru, Olivier Tribut, John DeVos, Rachel Jean, Nadège Bescher, Céline Monvoisin, and Rakesh K. Singh...... 3188 Joëlle Dulong, Thierry Lamy, Thierry Fest, and Karin Tarte ...... 3228

CD47 Regulates Bone Mass and Tumor Metastasis to Bone. Obituary Özge Uluçkan, Stephanie N. Becker, Hongju Deng, Wei Zou, Julie L. Prior, David Piwnica-Worms, William A. Frazier, Eugenia Calle: In Memoriam (1952–2009). and Katherine N. Weilbaecher ...... 3196 Christine B. Ambrosone ...... 3238

Naringenin: A Potential Immunomodulator for Inhibiting Lung Fibrosis and Metastasis. Gangjun Du, Lingtao Jin, Xiaofen Han, Corrections Zihui Song, Hongyan Zhang, and Wei Liang ...... 3205 Correction: Article on TP53 in BRCA1 Breast Tumors ...... 3240 Heterozygosity for Hypoxia Inducible Factor 1␣ Decreases the Correction: Article on Red and Processed Meats, Meat Mutagens, Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model. and Lung Cancer...... 3240 Jessica A. Bertout, Shetal A. Patel, Benjamin H. Fryer, Amy C. Durham, Correction: Article on MicroRNAs and DNA Repair...... 3240 Kelly L. Covello, Kenneth P. Olive, Michael H. Goldschmidt, and M. Celeste Simon ...... 3213 Correction: Review Article on Mesenchymal Stem Cells...... 3240

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Cancer Res 2009;69:2695-3240.

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