Table 4. 391 Probe Sets Still Rhythmic After Sleep Deprivation

Home , AlkB, CCDC85B, SULT1A1, Tetraspanin 9, TINF2, TMEM33

Table 4. 391 probe sets still rhythmic after sleep deprivation

noitpircseDlobmyS eneGDI xirtemyffA eneGDI noitpircseDlobmyS laV.P.jdasoc_emitnis_emitnoisseccA 1438211_s_at Dbp D site albumin promoter binding protein BB550183 -0.013 -0.877 1.44E-13 1418174_at Dbp D site albumin promoter binding protein BC018323 -0.036 -0.880 1.74E-13 1425099_a_at Arntl aryl hydrocarbon receptor nuclear translocator-like BC011080 0.135 0.418 1.02E-11 1416958_at Nr1d2 nuclear receptor subfamily 1, group D, member 2 NM_011584 -0.035 -0.397 7.53E-11 ta_7801241 doirep3reP golomoh 3 )alihposorD( 01-E64.3774.0-911.0-760110_MN 1450779_at Fabp7 fatty acid binding protein 7, brain NM_021272 0.433 0.404 3.82E-10 ta_5714241 hportoryhtfeT cinoyrbme rotcaf 90-E93.1972.0-311.0-986710CB )IBCN( ,921 ledom eneg921mGta_8815341 ledom ,921 )IBCN( 90-E71.4766.0-790.0-521704BB ta_2067141 doirep2reP golomoh 2 )alihposorD( 90-E79.5804.0-064.0-038530FA 1425560_a_at S100a16 S100 calcium binding protein A16 BC020031 0.228 0.194 5.97E-09 1435459_at Fmo2 flavin containing monooxygenase 2 BM936480 -0.255 -0.426 6.23E-09 ta_0537541 doirep2reP golomoh 2 )alihposorD( 90-E18.7584.0-213.0-689892GB ta_2985441 doireP2reP golomoh 2 )alihposorD( 80-E05.1234.0-003.0-813832MB 1448383_at Mmp14 matrix metallopeptidase 14 (membrane-inserted) NM_008608 0.082 0.474 3.74E-08 ta_6406541 39DC39dC negitna 80-E98.4023.0753.0441913VA 1429286_at 1190003M12Rik RIKEN cDNA 1190003M12 gene AK004474 -0.511 -0.245 5.08E-08 similar to Putative RNA-binding protein 3 (RNA- 1422660_at LOC671237 AY052560 -0.269 -0.318 5.40E-08 binding motif protein 3) 1416959_at Nr1d2 nuclear receptor subfamily 1, group D, member 2 NM_011584 -0.053 -0.408 1.45E-07 ta_6718541 doireP3reP golomoh 3 )alihposorD( 70-E71.2474.0-630.0-362120BB 1433733_a_at Cry1 cryptochrome 1 (photolyase-like) BG069864 -0.378 0.199 7.43E-07 1447676_x_at S100a16 S100 calcium binding protein A16 AV074236 0.201 0.180 9.29E-07 2 esaditpep cificeps nitiuqibu2psUta_a_8617141 cificeps esaditpep 2 60-E51.1063.0-910.0-493355IA ta_2498241 2tM nienoihtollatem 2 60-E44.2584.0-320.0-667697AA 01 nietorp enarbmemsnart01memTta_4585341 nietorp 01 60-E67.2663.0271.0037094WA 3 ylimaf niamod 22CST3d22csTta_a_2770241 niamod ylimaf 3 60-E49.2674.0-561.0-682010_MN 1436263_at Mobp myelin-associated oligodendrocytic basic protein AI839848 -0.024 -0.264 2.94E-06 1451355_at Asah3l N-acylsphingosine amidohydrolase 3-like AF282864 -0.023 -0.574 3.24E-06 1418187_at Ramp2 receptor (calcitonin) activity modifying protein 2 AF146523 0.051 -0.283 3.73E-06 3 ylimaf niamod 22CST3d22csTta_a_1825241 niamod ylimaf 3 60-E73.7864.0-061.0-982102FA ta_2593441 dioryhtarhT enomroh rotpecer ahpla 60-E73.7691.0-901.0600525IB ta_8828241 ekil-leppurK9flK rotcaf 9 60-E68.7512.0-920.0588884WA 1416572_at Mmp14 matrix metallopeptidase 14 (membrane-inserted) NM_008608 0.114 0.452 7.94E-06 1460510_a_at Coq10b coenzyme Q10 homolog B (S. cerevisiae) AK006551 -0.119 -0.220 9.54E-06 ta_3067141 doirep2reP golomoh 2 )alihposorD( 50-E80.1762.0-762.0-038530FA 1453435_a_at Fmo2 flavin containing monooxygenase 2 AK009753 -0.253 -0.471 1.12E-05 1426464_at Nr1d1 nuclear receptor subfamily 1, group D, member 1 W13191 0.373 -0.274 1.24E-05 1422869_at Mertk c-mer proto-oncogene tyrosine kinase NM_008587 -0.012 -0.346 1.25E-05 ta_3737541 debircsnarT--- sucol 50-E52.1023.0-762.0-600594BB 1428223_at Mfsd2 major facilitator superfamily domain containing 2 AK006096 -0.147 -0.258 1.33E-05 1423306_at 2010002N04Rik RIKEN cDNA 2010002N04 gene BI963682 -0.171 -0.346 1.49E-05 1 ahpla ,III epyt ,negallocorp1a3loCta_a_3887241 epyt ,III ahpla 1 50-E94.1503.0302.0526055WA 1422438_at Ephx1 epoxide hydrolase 1, microsomal NM_010145 0.055 -0.220 1.58E-05 Cables1 /// Cdk5 and Abl enzyme substrate 1 /// similar to Cdk5 1422477_at AF328140 -0.027 -0.298 1.62E-05 LOC635753 and Abl enzyme substrate 1 1422678_at Dgat2 diacylglycerol O-acyltransferase 2 AK002443 0.080 -0.199 1.80E-05 1451527_at Pcolce2 procollagen C-endopeptidase enhancer 2 AF352788 -0.057 -0.308 1.98E-05 ta_1818441 ekil-leppurK51flK rotcaf 51 50-E20.2723.0-540.0-684310CB ta_0013241 JBFsoF amocrasoetso enegocno 50-E85.2814.0272.0-716620VA 1418932_at Nfil3 nuclear factor, interleukin 3, regulated AY061760 0.111 0.288 3.55E-05 1420502_at Sat1 spermidine/spermine N1-acetyl transferase 1 NM_009121 -0.013 0.218 3.90E-05 2 esnopser htworg ylrae2rgEta_a_2867241 htworg esnopser 2 50-E87.5254.0004.0-64760X 5 nidualc5ndlCta_9387141 5 50-E70.6013.0100.0-508310_MN solute carrier family 2 (facilitated glucose 1434773_a_at Slc2a1 BM207588 -0.061 -0.268 6.60E-05 transporter), member 1 Adult male medulla oblongata cDNA, RIKEN full- 1435119_at --- length enriched library, clone:6330578N16 BE956710 -0.078 -0.515 7.29E-05 product:unclassifiable, full insert sequence ------ta_a_5202441 50-E11.8753.0-070.0756764IA interferon-induced protein with tetratricopeptide 1449025_at Ifit3 NM_010501 -0.190 -0.142 8.50E-05 repeats 3 1438648_x_at 1190003M12Rik RIKEN cDNA 1190003M12 gene AV069898 -0.292 -0.010 8.64E-05 1428332_at 1500004A08Rik RIKEN cDNA 1500004A08 gene AW556858 0.069 -0.193 8.95E-05 ta_5498441 amsalppllP enarbmem dipiloetorp 50-E54.9011.0871.0435420CB ta_2660641 doirep3reP golomoh 3 )alihposorD( 40-E10.1914.0-901.0-760110_MN solute carrier family 6 (neurotransmitter transporter, 1424338_at Slc6a13 BC023117 0.049 0.288 1.04E-04 GABA), member 13 ta_9617141 nitiuqibu2psU cificeps esaditpep 2 40-E41.1362.0-310.0493355IA 5 nietorp gnidnib 605KF5pbkFta_5216141 gnidnib nietorp 5 40-E65.1683.0-820.095961U 3D nilcyC3dncCta_9457541 3D 40-E65.1283.0-790.0-675340BB niclacsetcseTta_s_4478141 40-E28.1310.0-351.0443120_MN

SI Table4_1 Affymetrix ID Gene Symbol Description Accession time_sin time_cos adj.P.Val solute carrier family 2 (facilitated glucose 1426599_a_at Slc2a1 BM209618 -0.020 -0.287 1.82E-04 transporter), member 1 methylenetetrahydrofolate dehydrogenase (NADP+ 1456653_a_at Mthfd1l AV095209 -0.224 -0.158 1.82E-04 dependent) 1-like 1448807_at Hrh3 histamine receptor H 3 NM_133849 -0.027 -0.212 1.83E-04 1428736_at Gramd3 GRAM domain containing 3 AV259880 0.006 0.200 1.92E-04 1436735_at Nsun3 NOL1/NOP2/Sun domain family 3 BB769111 0.157 -0.125 1.98E-04 1434595_at Trim9 tripartite motif protein 9 BQ174474 0.110 0.142 2.09E-04 1457984_at Crh corticotropin releasing hormone BM933756 0.072 0.304 2.09E-04 1417574_at Cxcl12 chemokine (C-X-C motif) ligand 12 NM_013655 -0.192 0.267 2.28E-04 echinoderm microtubule associated protein like 1 /// Eml1 /// 1428321_at similar to echinoderm microtubule associated AK003593 0.139 0.196 2.76E-04 LOC634102 protein like 1 1428487_s_at Coq10b coenzyme Q10 homolog B (S. cerevisiae) AK002294 -0.133 -0.223 2.88E-04 glutamic pyruvate transaminase (alanine 1455007_s_at Gpt2 BI648645 -0.020 -0.242 2.96E-04 aminotransferase) 2 1449379_at Kdr kinase insert domain protein receptor NM_010612 0.090 0.235 3.30E-04 A2m /// alpha-2-macroglobulin /// hypothetical protein 1434719_at BB185854 0.106 0.190 3.31E-04 LOC677369 LOC677369 1425428_at Hif3a hypoxia inducible factor 3, alpha subunit AF416641 -0.128 -0.258 3.40E-04 1436050_x_at Hes6 hairy and enhancer of split 6 (Drosophila) AI326893 0.143 -0.202 3.44E-04 Leo1, Paf1/RNA polymerase II complex component, 1455293_at Leo1 BG065311 0.054 0.167 3.49E-04 homolog (S. cerevisiae) interleukin 22 /// interleukin 10-related T cell-derived 1427624_s_at Il22 /// Iltifb AJ249492 0.163 0.290 3.65E-04 inducible factor beta 1434735_at Hlf hepatic leukemia factor BB744589 -0.126 -0.155 3.65E-04 solute carrier family 2 (facilitated glucose 1426600_at Slc2a1 BM209618 -0.027 -0.297 3.66E-04 transporter), member 1 1434621_at BC054438 cDNA sequence BC054438 AV298104 0.125 -0.160 3.87E-04 1416101_a_at Hist1h1c histone 1, H1c NM_015786 0.172 0.104 4.17E-04 1426641_at Trib2 tribbles homolog 2 (Drosophila) BB354684 -0.106 0.256 5.26E-04 1447272_s_at Atp10a ATPase, class V, type 10A BM249532 -0.093 -0.366 6.94E-04 1416530_a_at Pnp purine-nucleoside phosphorylase BC003788 0.027 0.210 7.57E-04 1416892_s_at 3110001A13Rik RIKEN cDNA 3110001A13 gene BC021353 0.066 0.165 7.72E-04 protein phosphatase 1, regulatory (inhibitor) subunit 1418086_at Ppp1r14a NM_026731 0.214 0.167 8.07E-04 14A 1448929_at F13a1 coagulation factor XIII, A1 subunit NM_028784 -0.097 -0.237 8.07E-04 1424133_at Tmem98 transmembrane protein 98 BC011208 0.138 0.156 8.42E-04 1416332_at Cirbp cold inducible RNA binding protein NM_007705 -0.052 -0.324 9.12E-04 1437449_at Rsad1 radical S-adenosyl methionine domain containing 1 BB818348 0.152 -0.230 9.12E-04 1436387_at Homer1a RIKEN cDNA C330006P03 gene BB398124 -0.088 0.248 9.44E-04 1416591_at Rab34 RAB34, member of RAS oncogene family AF327929 0.177 -0.064 9.55E-04 nuclear factor of kappa light chain gene enhancer in 1448306_at Nfkbia NM_010907 -0.052 -0.306 9.55E-04 B-cells inhibitor, alpha 1450184_s_at Tef thyrotroph embryonic factor NM_017376 -0.105 -0.296 9.97E-04 1434235_at Slc20a2 solute carrier family 20, member 2 BB765719 0.161 0.102 0.0010 1455445_at Cbln3 cerebellin 3 precursor protein BB800230 0.207 -0.098 0.0010 1452975_at Agxt2l1 alanine-glyoxylate aminotransferase 2-like 1 AK005060 -0.202 -0.015 0.0012 1421086_at Per3 period homolog 3 (Drosophila) NM_011067 -0.047 -0.250 0.0018 1416967_at Sox2 SRY-box containing gene 2 U31967 -0.008 0.244 0.0019 1427683_at Egr2 early growth response 2 X06746 -0.356 0.275 0.0019 1448397_at Gjb6 gap junction membrane channel protein beta 6 BC016507 -0.114 -0.148 0.0019 solute carrier family 7 (cationic amino acid 1418326_at Slc7a5 BC026131 0.033 -0.252 0.0020 transporter, y+ system), member 5 1434736_at Hlf hepatic leukemia factor BB744589 -0.146 -0.134 0.0021 1449294_at Mrps15 mitochondrial ribosomal protein S15 NM_025544 0.149 -0.025 0.0021 1416505_at Nr4a1 nuclear receptor subfamily 4, group A, member 1 NM_010444 -0.184 0.184 0.0022 1425546_a_at Trf transferrin AF440692 0.161 0.028 0.0022 1428731_at Usp54 ubiquitin specific peptidase 54 AK019588 -0.019 -0.182 0.0022 1423723_s_at Tardbp TAR DNA binding protein BC012873 -0.025 0.134 0.0022 1416933_at Por P450 (cytochrome) oxidoreductase NM_008898 0.026 -0.125 0.0024 1416041_at Sgk serum/glucocorticoid regulated kinase NM_011361 -0.172 -0.600 0.0024 1419915_at D10Ertd438e DNA segment, Chr 10, ERATO Doi 438, expressed AW538011 -0.430 -0.017 0.0025 1434283_at Arid5b AT rich interactive domain 5B (Mrf1 like) BB079486 -0.059 -0.152 0.0026 1442243_at Per3 period homolog 3 (Drosophila) BB476794 -0.012 -0.232 0.0026 1456904_at --- Transcribed locus BQ101405 0.047 0.149 0.0026 1421037_at Npas2 neuronal PAS domain protein 2 BG070037 0.162 0.108 0.0027 1424885_at Klhdc8a kelch domain containing 8A BC011135 0.149 -0.010 0.0027 1429252_at 0610010K14Rik RIKEN cDNA 0610010K14 gene AK002491 0.248 0.014 0.0028 1418706_at Slc38a3 solute carrier family 38, member 3 NM_023805 0.122 -0.031 0.0028

SI Table4_2 Affymetrix ID Gene Symbol Description Accession time_sin time_cos adj.P.Val 1438796_at ------BE692107 -0.164 0.140 0.0028 homocysteine-inducible, endoplasmic reticulum 1448185_at Herpud1 NM_022331 -0.030 -0.131 0.0028 stress-inducible, ubiquitin-like domain member 1 ATP-binding cassette, sub-family G (WHITE), 1422906_at Abcg2 NM_011920 -0.109 -0.135 0.0029 member 2 1448276_at Tspan4 tetraspanin 4 NM_053082 0.051 -0.179 0.0030 1448609_at Tst thiosulfate sulfurtransferase, mitochondrial BC005644 0.122 0.154 0.0030 1416255_at Gja4 gap junction membrane channel protein alpha 4 AF216832 0.102 -0.219 0.0032 1423940_at Yif1a Yip1 interacting factor homolog A (S. cerevisiae) BC011117 0.113 0.109 0.0033 1110065P19Rik /// RIKEN cDNA 1110065P19 gene /// RIKEN cDNA 1452893_s_at BB772205 0.111 0.076 0.0033 2310040A07Rik 2310040A07 gene 1455344_at Efna3 ephrin A3 BE989942 0.039 -0.184 0.0033 1450713_at Cspg5 chondroitin sulfate proteoglycan 5 NM_013884 0.103 -0.095 0.0033 1460587_at B230215L15Rik RIKEN cDNA B230215L15 gene BB307661 0.048 0.232 0.0034 1451334_at 1810009O10Rik RIKEN cDNA 1810009O10 gene BC027022 0.115 0.105 0.0034 potassium channel tetramerisation domain 1441801_at Kctd4 AI843843 0.026 0.177 0.0034 containing 4 1429671_at 2410018M08Rik RIKEN cDNA 2410018M08 gene AK010551 0.219 -0.049 0.0037 cleavage and polyadenylation factor subunit 1427159_at Pcf11 AV374246 -0.063 -0.118 0.0038 homolog (S. cerevisiae) 1434151_at Mettl7a methyltransferase like 7A AV171622 -0.112 -0.091 0.0038 1450875_at Gpr37 G protein-coupled receptor 37 BQ175510 0.153 0.051 0.0038 1441445_at Per3 period homolog 3 (Drosophila) AW553065 -0.162 -0.370 0.0039 membrane bound O-acyltransferase domain 1423960_at Mboat5 BC006753 0.115 0.101 0.0041 containing 5 PREDICTED: Mus musculus hypothetical protein 1444177_at --- AI451538 0.222 -0.257 0.0042 LOC626058 (LOC626058), mRNA 1415899_at Junb Jun-B oncogene NM_008416 -0.198 0.106 0.0042 chaperone, ABC1 activity of bc1 complex like (S. 1417066_at Cabc1 AK014605 0.118 -0.083 0.0042 pombe) 1435866_s_at Hist3h2a histone 3, H2a AV297651 -0.119 0.097 0.0042 Mpa2l /// macrophage activation 2 like /// similar to 1447927_at LOC626578 /// macrophage activation 2 like /// similar to BG092512 -0.058 0.318 0.0043 LOC673101 macrophage activation 2 like 1449335_at Timp3 tissue inhibitor of metalloproteinase 3 BI111620 -0.060 -0.202 0.0043 1448117_at Kitl kit ligand BB815530 -0.135 0.048 0.0043 1424877_a_at Alad aminolevulinate, delta-, dehydratase BC018236 0.138 0.019 0.0044 TRAF2 and NCK interacting kinase /// similar to Tnik /// [Segment 1 of 2] Traf2 and NCK-interacting kinase 1430579_at LOC665113 /// AW045551 0.171 -0.053 0.0044 /// region containing TRAF2 and NCK interacting LOC674765 kinase; RIKEN cDNA C630040K21 gene 1456424_s_at Pltp phospholipid transfer protein AI591480 0.155 -0.032 0.0044 1436033_at BC031353 cDNA sequence BC031353 BG276629 0.061 -0.165 0.0044 1451612_at Mt1 metallothionein 1 BC027262 0.090 -0.202 0.0049 1452199_at 2700094F01Rik RIKEN cDNA 2700094F01 gene BB667255 0.123 -0.095 0.0049 1426235_a_at Glul glutamate-ammonia ligase (glutamine synthetase) AI391218 -0.109 -0.058 0.0050 1460219_at Mag myelin-associated glycoprotein NM_010758 0.132 -0.030 0.0056 1425553_s_at Hip1r huntingtin interacting protein 1 related AA590970 0.140 0.044 0.0061 protein phosphatase 1, regulatory (inhibitor) subunit 1433691_at Ppp1r3c BQ176864 0.024 0.122 0.0061 3C 1417818_at Wwtr1 WW domain containing transcription regulator 1 BC014727 0.168 0.089 0.0063 1424829_at A830007P12Rik RIKEN cDNA A830007P12 gene BC013092 -0.063 0.207 0.0063 1419845_at Dlx1as distal-less homeobox 1, antisense AI325350 -0.097 0.165 0.0065 solute carrier family 6 (neurotransmitter transporter), 1426712_at Slc6a15 BB129409 -0.077 -0.105 0.0067 member 15 CAP, adenylate cyclase-associated protein, 2 1450910_at Cap2 AV261931 0.073 0.085 0.0067 (yeast) 1428844_a_at Bclaf1 BCL2-associated transcription factor 1 BI965039 -0.155 -0.039 0.0067 1418595_at S3-12 plasma membrane associated protein, S3-12 NM_020568 -0.163 -0.564 0.0068 1435744_at 6720401G13Rik RIKEN cDNA 6720401G13 gene BG075556 0.070 -0.211 0.0068 1436200_at Lonrf3 LON peptidase N-terminal domain and ring finger 3 BE956940 -0.134 -0.116 0.0068 1416893_at 3110001A13Rik RIKEN cDNA 3110001A13 gene BC021353 0.073 0.115 0.0070 1427735_a_at Acta1 actin, alpha 1, skeletal muscle M12233 0.415 -0.010 0.0072 1431406_at Agxt2l1 alanine-glyoxylate aminotransferase 2-like 1 BC022644 -0.170 -0.336 0.0072 1450866_a_at Mrpl17 mitochondrial ribosomal protein L17 BQ179556 0.151 0.067 0.0072 solute carrier family 39 (zinc transporter), member 1433751_at Slc39a10 BM250411 -0.084 0.083 0.0073 10 1422733_at Fjx1 four jointed box 1 (Drosophila) AV230815 0.152 0.076 0.0075

SI Table4_3 Affymetrix ID Gene Symbol Description Accession time_sin time_cos adj.P.Val methyltransferase like 7A /// UbiE-YGHL1 fusion 1434150_a_at Mettl7a /// Ubie AV171622 -0.168 -0.151 0.0076 protein v-myc myelocytomatosis viral related oncogene, 1417155_at Mycn BC005453 0.006 0.171 0.0077 neuroblastoma derived (avian) 1418025_at Bhlhb2 basic helix-loop-helix domain containing, class B2 NM_011498 -0.045 -0.112 0.0077 1416111_at Cd83 CD83 antigen NM_009856 0.131 -0.067 0.0080 nuclear factor of kappa light chain gene enhancer in 1438157_s_at Nfkbia BB096843 -0.093 -0.312 0.0080 B-cells inhibitor, alpha 1425568_a_at Tmem33 transmembrane protein 33 BC005562 -0.148 0.077 0.0084 1416200_at 9230117N10Rik RIKEN cDNA 9230117N10 gene NM_133775 -0.044 -0.144 0.0085 1428495_at 2410003K15Rik RIKEN cDNA 2410003K15 gene BF300229 0.114 0.104 0.0087 1444139_at Ddit4l DNA-damage-inducible transcript 4-like BG797099 -0.058 0.113 0.0087 1434369_a_at Cryab crystallin, alpha B AV016515 -0.164 0.143 0.0091 1431042_at Paqr8 progestin and adipoQ receptor family member VIII AI530667 -0.081 -0.163 0.0092 1428197_at Tspan9 tetraspanin 9 AK020159 0.108 -0.014 0.0092 1451555_at Nln neurolysin (metallopeptidase M3 family) BC016224 0.149 -0.082 0.0092 SWI/SNF related, matrix associated, actin 1430526_a_at Smarca2 dependent regulator of chromatin, subfamily a, AK011935 -0.139 -0.042 0.0093 member 2 1423192_at Pspc1 paraspeckle protein 1 BB590675 0.080 -0.121 0.0093 1457325_at Kcns2 K+ voltage-gated channel, subfamily S, 2 BB442995 0.124 0.061 0.0095 1429060_at ------AK020483 -0.075 0.128 0.0101 1449851_at Per1 period homolog 1 (Drosophila) AF022992 -0.074 -0.268 0.0101 1452217_at Ahnak AHNAK nucleoprotein (desmoyokin) BE570050 -0.045 -0.219 0.0101 1435407_at Zfp483 Zinc finger protein 483 BQ175781 0.145 -0.099 0.0103 1417045_at Bid BH3 interacting domain death agonist NM_007544 0.147 0.071 0.0106 1423853_at 6330527O06Rik RIKEN cDNA 6330527O06 gene BC004791 -0.005 0.097 0.0108 Adult male vesicular gland cDNA, RIKEN full-length 1442917_at --- enriched library, clone:G630023F10 BM195384 -0.104 -0.223 0.0110 product:unclassifiable, full insert sequence 1459372_at Npas4 neuronal PAS domain protein 4 AV348246 -0.019 0.310 0.0111 1460240_a_at Hnrpc heterogeneous nuclear ribonucleoprotein C NM_016884 0.011 0.120 0.0111 sulfotransferase family 1A, phenol-preferring, 1427345_a_at Sult1a1 AK002700 -0.195 -0.325 0.0111 member 1 1454725_at Tra2a transformer 2 alpha homolog (Drosophila) BG069073 -0.162 0.054 0.0111 1451163_at Tinf2 Terf1 (TRF1)-interacting nuclear factor 2 AF214013 0.109 -0.074 0.0112 mitogen activated protein kinase 8 interacting 1440619_at Mapk8ip1 BB546463 0.083 0.102 0.0114 protein 1 1459746_at R3hdm1 R3H domain 1 (binds single-stranded nucleic acids) AW125678 -0.065 0.149 0.0117 1423289_a_at 1810029B16Rik RIKEN cDNA 1810029B16 gene BG069652 -0.004 -0.231 0.0118 1424007_at Gdf10 growth differentiation factor 10 L42114 -0.003 -0.181 0.0118 1426722_at Slc38a2 solute carrier family 38, member 2 BM248527 -0.077 -0.087 0.0118 1426548_a_at Atpbd4 ATP binding domain 4 BG070516 0.167 -0.048 0.0122 1439087_a_at 1500004A08Rik RIKEN cDNA 1500004A08 gene BB030508 -0.014 -0.182 0.0123 1439293_at C130047D21Rik RIKEN cDNA C130047D21 gene BB369212 0.026 -0.171 0.0126 1454858_x_at Mettl7a methyltransferase like 7A AV171622 -0.098 -0.172 0.0126 1428317_at ------AI510221 0.007 -0.142 0.0126 1448705_at Zbtb22 zinc finger and BTB domain containing 22 BC026964 0.145 0.046 0.0126 1428889_at Alkbh3 alkB, alkylation repair homolog 3 (E. coli) AK007557 0.105 -0.067 0.0127 1450436_s_at Dnajb5 DnaJ (Hsp40) homolog, subfamily B, member 5 AI664344 -0.063 0.109 0.0127 1455333_at Tns3 tensin 3 AI315031 -0.027 -0.132 0.0127 1431360_s_at Dmrtc1a DMRT-like family C1a AI430409 0.032 -0.142 0.0131 1436843_at C430048L16Rik RIKEN cDNA C430048L16 gene AV299215 -0.179 0.055 0.0131 1443053_at Ptprd Protein tyrosine phosphatase, receptor type, D BB523104 -0.069 -0.231 0.0135 Mid1 interacting protein 1 (gastrulation specific G12- 1416840_at Mid1ip1 NM_026524 0.014 0.103 0.0135 like (zebrafish)) 1452061_s_at Strbp spermatid perinuclear RNA binding protein AK006314 -0.053 0.114 0.0137 1453119_at Otud1 OTU domain containing 1 BB530087 -0.117 0.141 0.0137 DNA segment, Chr 9, University of California at Los 1424086_at D9Ucla1 BC025514 0.032 -0.131 0.0137 Angeles 1 1435594_at Arl6ip2 ADP-ribosylation factor-like 6 interacting protein 2 AV334690 0.123 -0.074 0.0138 1449533_at Tmem100 transmembrane protein 100 NM_026433 0.081 0.156 0.0138 1458087_at Stac3 SH3 and cysteine rich domain 3 BB135364 -0.132 -0.116 0.0138 1416086_at Tpst2 protein-tyrosine sulfotransferase 2 NM_009419 0.049 -0.124 0.0141 1428573_at Chn2 chimerin (chimaerin) 2 AK006398 0.104 -0.067 0.0141 1439837_at Tnrc15 trinucleotide repeat containing 15 BE136147 0.177 0.058 0.0141 1447854_s_at Hist2h2be histone 2, H2be AV127319 -0.034 0.196 0.0141 1423085_at Efnb3 ephrin B3 BQ175608 0.161 -0.026 0.0142 1426348_at Col4a1 procollagen, type IV, alpha 1 BF158638 0.131 0.101 0.0142 Lonrf1 /// LON peptidase N-terminal domain and ring finger 1 1455665_at BB705689 -0.118 -0.041 0.0147 LOC631639 /// similar to CG32369-PB, isoform B

SI Table4_4 Affymetrix ID Gene Symbol Description Accession time_sin time_cos adj.P.Val 1415904_at Lpl lipoprotein lipase BC003305 0.070 0.170 0.0149 1420012_at Xbp1 X-box binding protein 1 C77390 -0.241 -0.006 0.0149 1443401_at Astn2 Astrotactin 2 BM941510 0.023 -0.181 0.0149 1428173_at Eml2 echinoderm microtubule associated protein like 2 AK005562 -0.043 -0.114 0.0154 1428375_at 4932415G12Rik RIKEN cDNA 4932415G12 gene AK015136 0.162 -0.100 0.0154 Williams-Beuren syndrome chromosome region 18 1418081_at Wbscr18 NM_025362 0.109 0.020 0.0154 homolog (human) 1423717_at Ak3 adenylate kinase 3 BC019174 -0.089 -0.083 0.0159 1436329_at Egr3 early growth response 3 AV346607 -0.104 0.141 0.0160 1427410_at Dleu2 deleted in lymphocytic leukemia, 2 BB812902 -0.064 0.094 0.0161 1424068_at Tcta T-cell leukemia translocation altered gene BC019397 0.122 -0.043 0.0166 1428747_at Trspap1 tRNA selenocysteine associated protein 1 AK003534 0.126 0.029 0.0169 1444072_at --- Transcribed locus AW123332 0.134 -0.164 0.0170 1426368_at Rin2 Ras and Rab interactor 2 AK014548 -0.069 -0.199 0.0177 1429363_at Vps37a vacuolar protein sorting 37A (yeast) BB815335 -0.054 0.199 0.0181 1448188_at Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) BC012697 -0.006 -0.136 0.0181 1418472_at Aspa aspartoacylase (aminoacylase) 2 BC024934 0.062 0.137 0.0182 1454614_at 1810013D10Rik RIKEN cDNA 1810013D10 gene C87702 0.135 0.040 0.0182 1455710_x_at Mtcp1 mature T-cell proliferation 1 AI528732 0.059 0.109 0.0182 1441360_at Rps6ka3 Ribosomal protein S6 kinase polypeptide 3 AW546661 0.058 0.145 0.0184 sprouty protein with EVH-1 domain 1, related 1423160_at Spred1 BQ044290 -0.086 0.108 0.0187 sequence 1416855_at Gas1 growth arrest specific 1 BB550400 0.028 0.124 0.0189 1423591_at Fgfr1op2 FGFR1 oncogene partner 2 AK004662 -0.059 -0.063 0.0192 1423655_a_at 1500010J02Rik RIKEN cDNA 1500010J02 gene BC014687 0.086 -0.084 0.0192 1430154_at 4930543C13Rik RIKEN cDNA 4930543C13 gene AI666321 -0.113 0.028 0.0192 1457184_at Frmd6 FERM domain containing 6 BB472173 -0.033 0.202 0.0193 1428342_at Rcor3 REST corepressor 3 BB667699 0.122 -0.020 0.0199 1442138_at Gpr62 G protein-coupled receptor 62 BE955672 0.211 0.021 0.0202 1424596_s_at Lmcd1 LIM and cysteine-rich domains 1 BC019124 0.134 0.181 0.0202 1438044_at 1700047M11Rik RIKEN cDNA 1700047M11 gene BB534060 0.150 0.001 0.0207 1416150_a_at Sfrs3 splicing factor, arginine/serine-rich 3 (SRp20) NM_013663 -0.082 -0.067 0.0208 1448793_a_at Sdc4 syndecan 4 BC005679 -0.083 -0.237 0.0208 Hist1h4h /// Hist2h4 /// Hist1h4c /// Hist1h4i /// histone 1, H4h /// histone 2, H4 /// histone 1, H4c /// 1422948_s_at Hist1h4j /// histone 1, H4i /// histone 1, H4j /// histone 1, H4k /// NM_013550 0.086 0.102 0.0211 Hist1h4k /// histone 1, H4m /// histone 1, H4a /// histone 1, H4b Hist1h4m /// Hist1h4a /// Hist1h4b 1450782_at Wnt4 wingless-related MMTV integration site 4 NM_009523 0.133 -0.073 0.0213 1426973_at Gpr153 G protein-coupled receptor 153 AK004377 0.110 -0.089 0.0216 1423939_a_at Yif1a Yip1 interacting factor homolog A (S. cerevisiae) BC011117 0.116 0.048 0.0216 1435511_at Syn2 synapsin II BM898679 0.085 -0.094 0.0217 1433387_at 2900022M07Rik RIKEN cDNA 2900022M07 gene AK013576 -0.229 -0.050 0.0218 1436088_at 0910001A06Rik RIKEN cDNA 0910001A06 gene AV033641 0.058 -0.109 0.0218 1438916_x_at 6720401G13Rik RIKEN cDNA 6720401G13 gene AI452037 0.143 0.027 0.0218 1449037_at Crem cAMP responsive element modulator AI467599 -0.008 0.158 0.0218 1423718_at Ak3 adenylate kinase 3 BC019174 -0.081 -0.091 0.0229 calcium/calmodulin-dependent protein kinase I 1424633_at Camk1g AF428262 0.038 -0.126 0.0229 gamma 1434031_at Zfp692 zinc finger protein 692 BB037019 0.089 0.048 0.0229 1435551_at Fhod3 formin homology 2 domain containing 3 BG066491 0.106 -0.037 0.0229 1433928_a_at Rpl13a ribosomal protein L13a BF146301 -0.025 0.111 0.0233 1415756_a_at Snapap SNAP-associated protein BB667523 0.120 -0.015 0.0233 pleckstrin homology domain containing, family F 1424671_at Plekhf1 BC002120 -0.057 -0.236 0.0233 (with FYVE domain) member 1 1437904_at Drbp1 developmentally regulated RNA binding protein 1 BB821609 0.271 0.134 0.0235 1454109_a_at Ptdsr phosphatidylserine receptor AK017622 -0.149 0.008 0.0236 1416590_a_at Rab34 RAB34, member of RAS oncogene family AF327929 0.139 -0.027 0.0239 1456510_x_at Ubie UbiE-YGHL1 fusion protein BB703414 -0.104 -0.114 0.0239 fascin homolog 1, actin bundling protein 1416514_a_at Fscn1 NM_007984 0.035 0.104 0.0239 (Strongylocentrotus purpuratus) low density lipoprotein receptor-related protein 1426697_a_at Lrpap1 D00622 0.080 -0.071 0.0242 associated protein 1 1431043_at Kbtbd5 kelch repeat and BTB (POZ) domain containing 5 W78395 0.125 -0.091 0.0242 1429144_at Prei4 preimplantation protein 4 AV291259 -0.011 -0.127 0.0244 1424760_a_at Smyd2 SET and MYND domain containing 2 BC023119 0.083 -0.054 0.0250

SI Table4_5 Affymetrix ID Gene Symbol Description Accession time_sin time_cos adj.P.Val sprouty protein with EVH-1 domain 1, related 1428777_at Spred1 AK017680 -0.136 0.096 0.0254 sequence phosphatidylinositol glycan anchor biosynthesis, 1436038_a_at Pigp BF318238 0.109 0.048 0.0258 class P 1427245_at Arfgap1 ADP-ribosylation factor GTPase activating protein 1 BM196296 0.084 -0.012 0.0268 1451536_at Mtfr1 mitochondrial fission regulator 1 AK009195 -0.111 0.142 0.0268 1428099_a_at Sfrs1 splicing factor, arginine/serine-rich 1 (ASF/SF2) BF147037 -0.128 0.039 0.0269 1438816_at Ahctf1 AT hook containing transcription factor 1 BM247201 -0.113 0.011 0.0271 1416129_at Errfi1 ERBB receptor feedback inhibitor 1 NM_133753 -0.052 -0.090 0.0273 1417335_at Sult2b1 sulfotransferase family, cytosolic, 2B, member 1 NM_017465 -0.041 -0.159 0.0273 1424383_at Tmem51 transmembrane protein 51 BC003277 0.034 0.149 0.0274 splicing factor, arginine/serine-rich 10 (transformer 2 1419543_a_at Sfrs10 BG229318 -0.113 -0.052 0.0277 homolog, Drosophila) Cytochrome P450, family 4, subfamily x, polypeptide 1441662_at Cyp4x1 BB171122 0.124 0.151 0.0277 1 1425900_at Hkdc1 hexokinase domain containing 1 BC016235 0.189 -0.004 0.0277 1435589_at Ccdc85b coiled-coil domain containing 85B AV308222 -0.021 -0.151 0.0283 1426094_at Rhbdl1 rhomboid, veinlet-like 1 (Drosophila) BC021549 0.065 -0.084 0.0287 1433936_at 0610010E21Rik RIKEN cDNA 0610010E21 gene BG791555 0.137 0.048 0.0289 1436610_at Ankrd12 ankyrin repeat domain 12 BQ176856 0.140 -0.100 0.0294 proteasome (prosome, macropain) inhibitor subunit 1424370_s_at Psmf1 BC012260 0.146 -0.101 0.0295 1 protein kinase, AMP-activated, beta 1 non-catalytic 1424119_at Prkab1 BC016398 0.150 -0.016 0.0295 subunit 1444452_at D930002L09Rik RIKEN cDNA D930002L09 gene BB560393 0.056 -0.174 0.0299 1452738_at Stoml1 stomatin-like 1 AK007508 0.104 -0.054 0.0301 1431170_at Efna3 ephrin A3 AA388313 0.076 -0.080 0.0305 1428184_at 3110035E14Rik RIKEN cDNA 3110035E14 gene BB348639 0.063 0.088 0.0305 1423946_at Pdlim2 PDZ and LIM domain 2 BC024556 -0.002 -0.133 0.0309 1434352_at B630005N14Rik RIKEN cDNA B630005N14 gene BB329261 -0.114 -0.068 0.0309 1452194_at Tbcd tubulin-specific chaperone d AK020695 0.076 -0.061 0.0309 anillin, actin binding protein (scraps homolog, 1433543_at Anln BI690018 -0.103 -0.060 0.0312 Drosophila) 1417740_at Cdc37l1 cell division cycle 37 homolog (S. cerevisiae)-like 1 BB756370 -0.036 -0.114 0.0315 1448441_at Cks1b CDC28 protein kinase 1b NM_016904 -0.059 -0.135 0.0317 1415948_at Creg1 cellular repressor of E1A-stimulated genes 1 BC027426 0.044 -0.088 0.0320 Tnik /// TRAF2 and NCK interacting kinase /// similar to 1458403_at BB222494 0.096 -0.135 0.0328 LOC665113 [Segment 1 of 2] Traf2 and NCK-interacting kinase 1434203_at BC055107 cDNA sequence BC055107 BF682848 -0.034 -0.121 0.0331 1429764_at 1500005K14Rik RIKEN cDNA 1500005K14 gene BF101721 0.158 0.123 0.0331 nudix (nucleoside diphosphate linked moiety X)-type 1435902_at Nudt18 BM120193 0.111 -0.013 0.0331 motif 18 1420441_at Cenpc1 centromere protein C1 NM_007683 -0.071 0.127 0.0334 1448948_at Rag1ap1 recombination activating gene 1 activating protein 1 NM_009057 0.106 -0.024 0.0342 1439630_x_at Sbsn suprabasin AI844734 -0.081 -0.328 0.0342 1448830_at Dusp1 dual specificity phosphatase 1 NM_013642 -0.125 0.111 0.0344 1421844_at ------BE285634 0.027 -0.164 0.0353 1425196_a_at Hint2 histidine triad nucleotide binding protein 2 AF356874 0.119 -0.009 0.0353 1449523_at Bcl7c B-cell CLL/lymphoma 7C NM_009746 0.125 0.025 0.0353 Cdh15 /// cadherin 15 /// similar to Muscle-cadherin precursor 1418602_at NM_007662 0.117 0.068 0.0356 LOC672914 (M-cadherin) (Cadherin-15) (Cadherin-14) human immunodeficiency virus type I enhancer 1422742_at Hivep1 NM_007772 0.044 0.117 0.0357 binding protein 1 1448619_at Dhcr7 7-dehydrocholesterol reductase NM_007856 0.109 0.093 0.0357 1450522_a_at H1f0 H1 histone family, member 0 NM_008197 0.102 -0.013 0.0357 1453141_at 0610009L18Rik RIKEN cDNA 0610009L18 gene BE370605 0.167 0.059 0.0357 1455239_at 6330512M04Rik RIKEN cDNA 6330512M04 gene BM116861 0.086 0.002 0.0357 1426698_a_at Hnrpm heterogeneous nuclear ribonucleoprotein M AK011521 -0.085 0.058 0.0358 1439561_at 2010012O05Rik RIKEN cDNA 2010012O05 gene BB322051 0.150 -0.128 0.0358 1440224_at 9330133O14Rik RIKEN cDNA 9330133O14 gene BB077224 0.135 0.078 0.0358 solute carrier family 3 (activators of dibasic and 1425364_a_at Slc3a2 U25708 0.003 -0.081 0.0362 neutral amino acid transport), member 2 1416155_at Hmgb3 high mobility group box 3 NM_008253 -0.038 -0.103 0.0363 1416455_a_at Cryab crystallin, alpha B NM_009964 -0.121 0.112 0.0363 1423702_at H1f0 H1 histone family, member 0 BC003830 0.077 -0.061 0.0366 1448364_at Ccng2 cyclin G2 U95826 -0.111 0.005 0.0376 1436100_at Sh2d5 SH2 domain containing 5 AV347995 0.015 -0.107 0.0378

SI Table4_6 Affymetrix ID Gene Symbol Description Accession time_sin time_cos adj.P.Val carbohydrate (N-acetylgalactosamine 4-0) 1428977_at Chst8 AK005217 0.132 0.007 0.0387 sulfotransferase 8 1449903_at Crtam cytotoxic and regulatory T cell molecule NM_019465 0.043 -0.135 0.0392 1428232_at Cpsf6 cleavage and polyadenylation specific factor 6 BB425379 -0.117 -0.002 0.0403 1438426_at Tmem58 transmembrane protein 58 BF468228 0.102 0.009 0.0403 1416778_at Sdpr serum deprivation response BE197945 -0.048 -0.156 0.0405 solute carrier family 7 (cationic amino acid 1426069_s_at Slc7a4 BC016100 0.097 -0.010 0.0405 transporter, y+ system), member 4 1428470_at Exoc2 exocyst complex component 2 AK010620 0.115 -0.042 0.0405 1424712_at Ahctf1 AT hook containing transcription factor 1 BC023122 -0.103 -0.021 0.0406 1416303_at Litaf LPS-induced TN factor AV360881 0.080 0.077 0.0413 1428725_at Pias2 protein inhibitor of activated STAT 2 AK018146 -0.072 0.055 0.0413 similar to Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar 1445504_at LOC331392 BB049966 0.072 0.061 0.0417 phosphoprotein) (Nopp140) (Nucleolar and coiled- body phosphoprotein 1) 1440476_at D6Ertd474e DNA segment, Chr 6, ERATO Doi 474, expressed BG068519 0.117 0.100 0.0417 1437670_x_at Cd151 CD151 antigen BB113673 0.107 0.003 0.0419 1418816_at Chmp1b chromatin modifying protein 1B BG073376 -0.087 0.100 0.0421 1448028_at Tbc1d24 TBC1 domain family, member 24 BF536757 0.174 -0.049 0.0424 1424768_at Cald1 caldesmon 1 BI248947 -0.021 0.177 0.0425 1456341_a_at Klf9 Kruppel-like factor 9 AV354744 0.020 -0.174 0.0430 calcium/calmodulin-dependent protein kinase II 1423941_at Camk2g BM227770 0.056 -0.081 0.0433 gamma DNA segment, Chr 17, Wayne State University 104, 1448439_at D17Wsu104e NM_080837 0.082 -0.076 0.0433 expressed 1455225_at Syne1 synaptic nuclear envelope 1 AV237615 -0.091 0.014 0.0433 1424777_at Wdr21 WD repeat domain 21 BC003284 0.099 0.082 0.0434 1436164_at Slc30a1 solute carrier family 30 (zinc transporter), member 1 BE685959 0.112 -0.058 0.0434 1454653_at Cpne9 copine family member IX BB274531 0.012 -0.109 0.0434 1428758_at Tmem86a transmembrane protein 86A AK007864 0.043 -0.107 0.0436 v-erb-b2 erythroblastic leukemia viral oncogene 1434606_at Erbb3 BF140685 -0.066 0.118 0.0438 homolog 3 (avian) protein phosphatase 2C, magnesium dependent, 1434228_at Ppm2c AV255921 -0.075 0.075 0.0442 catalytic subunit 1423186_at Tiam2 T-cell lymphoma invasion and metastasis 2 BM228957 -0.081 -0.084 0.0443 H2afj /// H2A histone family, member J /// similar to H2A 1424772_at BF661121 -0.088 0.096 0.0443 LOC632401 histone family, member J isoform 2 1417065_at Egr1 early growth response 1 NM_007913 -0.168 0.111 0.0443 1416755_at Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 AK002290 -0.147 0.067 0.0445 1436515_at E030004N02Rik RIKEN cDNA E030004N02 gene BB529913 0.137 0.042 0.0452 1419072_at Gstm7 glutathione S-transferase, mu 7 NM_026672 0.128 -0.007 0.0455 1453421_at Srr serine racemase AK002636 0.052 0.084 0.0457 1428465_at Tmem147 transmembrane protein 147 AK010168 0.051 0.057 0.0459 1451489_at Slc25a35 solute carrier family 25, member 35 BC019996 0.011 -0.144 0.0462 1460644_at Bckdk branched chain ketoacid dehydrogenase kinase NM_009739 0.106 0.026 0.0466 1455845_at BC030477 cDNA sequence BC030477 AV099154 0.117 0.030 0.0467 1425292_at Dtna dystrobrevin alpha AF143543 0.104 -0.029 0.0468 1433529_at E430002G05Rik RIKEN cDNA E430002G05 gene AU067747 0.132 -0.045 0.0468 deformed epidermal autoregulatory factor 1 1448446_at Deaf1 NM_016874 0.041 -0.119 0.0473 (Drosophila) 1415793_at Pnpo pyridoxine 5'-phosphate oxidase NM_134021 0.017 -0.081 0.0474 1419248_at Rgs2 regulator of G-protein signaling 2 AF215668 -0.025 0.081 0.0487 1441324_at Zfp395 Zinc finger protein 395 BB362177 -0.147 0.133 0.0490 1454885_at BC063263 cDNA sequence BC063263 BM211194 -0.167 0.040 0.0492 glutamic pyruvate transaminase (alanine 1439029_at Gpt2 BG069993 -0.005 -0.144 0.0494 aminotransferase) 2 1436703_x_at Snapc2 small nuclear RNA activating complex, polypeptide 2 BB461550 0.097 -0.013 0.0495 1457092_at C630007B19Rik RIKEN cDNA C630007B19 gene AW121549 0.022 0.107 0.0499 amyloid beta (A4) precursor protein-binding, family 1424457_at Apbb3 BC024809 0.023 -0.103 0.0500 B, member 3

SI Table4_7