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Celebration of Science Research Training: the Roads Ahead the Roads Training: Research 68th Annual Meeting of the MGH Scientific Advisory Committee Celebration of Science April 1 and 2, 2015 Simches Auditorium 185 Cambridge Street, 3rd Floor Celebration of Science Research Training: The Roads Ahead ECOR Administrative Offices | 50 Staniford Street, 10th Floor | Boston, MA 02114 | [email protected] Welcome elcome to the 68th Annual Meeting of the MGH Scientific Advisory Committee (SAC) on April 1st and 2nd, 2015. As in past years, we will begin our two-day SAC meeting Our afternoon session will include three focused panel with a Celebration of Science at MGH. Our poster session discussions on training at MGH including: begins at 11:00 am on Wednesday, April 1, followed by an afternoon Research Symposium from 2:00 pm to Graduate Students–moderated by Thilo Deckersbach, PhD 5:00 pm. The outstanding MGH researchers who will be Basic Research Fellows–moderated by Dennis Brown, PhD presenting their work in our Symposium this year are the 2015 Howard Goodman Award recipient Alexander Soukas, Clinical Research Fellows–moderated by Andrew A. MD, PhD and the 2015 Martin Basic and Clinical Research Nierenberg, MD Prize recipients, Shyamala Maheswaran, PhD, and Sekar Experience has reaffirmed that we get the most helpful Kathiresan, MD. We are honored to have as our keynote advice and perspective from SAC via open discussion of speaker, Constance L. Cepko, PhD, from HMS. We will close key issues. This year we have made a concerted effort to the first day with a reception and dinner for invited guests shorten presentations to allow more time for discussion at the Liberty Hotel. with the SAC members. On Thursday, April 2, Dr. Kingston will open the SAC Also on Thursday, SAC members will again have meeting with an ECOR Report. After this report, Anne the opportunity to meet with small groups of MGH Klibanski, MD, Partners Chief Academic Officer, will give investigators in unstructured, informal conversations a presentation on the “Integration of MGH Research to during lunch. the Partners Enterprise”. We will next turn our attention to department presentations by the Directors of the Ragon To maximize the time for discussion during the day, the Institute of MGH, MIT and Harvard (Bruce Walker, MD) annual MGH Research Administration Executive Report and the MGH Cancer Center (Daniel A. Haber, MD, PhD), and Financials for FY14 will be provided in these printed who will describe some of the remarkable research being materials in advance of the meeting. conducted across MGH. Dr. Kingston plans to highlight some of this information in Training biomedical scientists in the current funding his annual ECOR Report and there will be an opportunity for climate has numerous well appreciated challenges. This SAC members to ask questions about the written report. year seems an appropriate time to focus on how we meet those challenges and create opportunities for the various We look forward to an engaging and stimulating two days types of trainees we have at MGH. of discussion and appreciate your participation. Peter L. Slavin, MD Robert E. Kingston, PhD Harry W. Orf, PhD PRESIDENT CHAIR, EXECUTIVE COMMITTEE SENIOR VICE PRESIDENT ON RESEARCH FOR RESEARCH SAC 2015 Executive Committee on RESEARCH 1 Wednesday, April 1, 2015 Annual Celebration of Science at MGH 11:00 am–1:45 pm | Simches, Floors 2 & 3 3:15–3:45 pm SAC 2015 Poster Session (light lunch available) 2015 Goodman Award Regulation of starvation survival and fat storage 2:00–5:00 pm | Simches 3.110 by thrifty metabolic pathways Scientific Presentations Alexander A. Soukas, MD, PhD Welcome 3:45–4:00 pm Peter L. Slavin, MD, President, Break Massachusetts General Hospital 4:00–5:00 pm Opening Comments and Introductions Keynote Address Robert E. Kingston, PhD, Chair, Reflections on Research Training Executive Committee On Research (ECOR) Constance L. Cepko, PhD, Professor, Genetics and Ophthalmology, Harvard Medical School 2015 MGH Research Scholars Investigator, Howard Hughes Medical Institute Dr. Kingston 6:00–9:00 pm 2:15–2:45 pm Colloquium Dinner & Reception (for invited guests) 2015 Martin Prize for Basic Research Targeting Cancer Metastasis through 6:00–7:00 pm Circulating Tumor Cells Reception Shyamala Maheswaran, PhD 7:00–9:00 pm 2:45–3:15 pm Dinner 2015 Martin Prize for Clinical Research Leveraging human ‘knockouts’ to understand After Dinner Remarks wellness and disease The MGH Research Institute Sekar Kathiresan, MD Susan A. Slaugenhaupt, PhD Scientific Director, MGH Research Institute 2 Executive Committee on RESEARCH SAC 2015 Thursday, April 2, 2015 Annual Celebration of Science at MGH 8:00–9:00 am | Simches 3.120 1:10–4:15 pm | Simches 3.110 Breakfast Research Training: The Roads Ahead SAC Members with ECOR leadership 1:10–1:20 pm 9:00–9:15 am | Simches 3.110 Opening Summary/Overview of Issue Welcome and Opening Comments Robert E. Kingston, PhD Peter L. Slavin, MD, President, Massachusetts General Hospital Discussion Items Roadblocks and Speedbumps 9:15–9:40 am The current challenges facing trainees ECOR Report Destinations Robert E. Kingston, PhD, Chair, The opportunities & possible solutions Executive Committee On Research (ECOR) Bridges & Highways The resources required to reach solutions 9:40–10:00 am Integration of MGH Research 1:20–2:00 pm to the Partners Enterprise Graduate Students Anne Klibanski, MD, Partners Chief Academic Officer Moderator: Thilo Deckersbach, PhD Panel: David Fisher, MD, PhD; David Langenau, PhD; 10:00–11:30 am Andrea McClatchey, PhD Department Reports 2:00–2:40 pm 10:00–10:40 am Basic Scientist Fellows Ragon Institute of MGH, MIT and Harvard Moderator: Dennis Brown, PhD Bruce Walker, MD Panel: Bradley E. Bernstein, MD, PhD; Sylvie Breton, PhD; Robert E. Kingston, PhD 10:40–10:50 am Break 2:40–3:00 pm Break 10:50–11:30 am MGH Cancer Center, Daniel A. Haber, MD, PhD 3:00–3:40 pm Physician Scientist Fellows 11:30–1:00 pm | Simches, Floor 2 Moderator: Andrew A. Nierenberg, MD Lunch Panel: Marcia Goldberg, MD; Jay Rajagopal, MD; SAC Members with Faculty Ravi Thadhani, MD, MPH 3:40–4:15 pm Open discussion: “How does MGH capitalize in times of disruption?” 4:15–4:45 pm | Simches 3.120 Executive Session (SAC members only) 4:45–5:15 pm | Simches 3.120 Debriefing (SAC members and MGH Leadership) SAC 2015 Executive Committee on RESEARCH 3 Goodman & Martin Award Winners 2015 Howard M. Goodman 2015 Martin Research Prize for Fellowship Basic and Clinical Research The Fellowship honors Howard M. Goodman, founder of The Martin Research Prizes were established to honor the MGH Department of Molecular Biology in 1982 and Joseph B. Martin, MD, PhD, who was Dean of Harvard Chief of that Department until 2004. Dr. Goodman’s guiding Medical School from July 1997 to July 2007. Prior to principle was that great science should not be encumbered becoming Dean, Dr. Martin was Chief of the Neurology by the continual need to convince the world concerning Service at MGH. Each year, ECOR awards two $100,000 the merit of an individual scientific vision. He believed Martin Research Prizes to recognize outstanding research in choosing scientists of demonstrated excellence and papers published by MGH investigators in Basic research giving them the resources to pursue their goals with vigor, and Clinical research. a model that was resoundingly successful. Each year a Goodman Fellow is chosen from the MGH community to Basic Research honor that legacy and to support the pursuit of excellence Targeting Cancer Metastasis by young scientists of uncommon passion and ability. through Circulating Tumor Cells Shyamala Maheswaran, PhD Regulation of starvation survival and fat Associate Professor storage by thrifty metabolic pathways Surgery & Cancer Center Alexander A. Soukas, MD, PhD Assistant Professor Endocrine, Diabetes Unit & Center for Human Genetic Research Clinical Research Leveraging human ‘knockouts’ to understand wellness and disease Sekar Kathiresan, MD Associate Professor Cardiology & Center for Human Genetic Research 4 Executive Committee on RESEARCH SAC 2015 SAC 2015 Executive Committee on RESEARCH 5 Keynote Speaker Constance L. Cepko, PhD Dr. Cepko is the Bullard Professor of Neuroscience and Genetics, in the Departments of Genetics and Ophthalmology at Harvard Medical School, and an Investigator at the Howard Hughes Medical Institute. She was an undergraduate at the University of Maryland and a PhD student at MIT, where she worked with Phillip Sharp on the assembly of the adenovirus capsid. She remained at MIT as a postdoctoral fellow in the laboratory of Richard Mulligan, where she was involved in the development of the first retroviral vectors. Her current research is focussed on the development of the central nervous system, with an emphasis on the retina. Her laboratory employs molecular and cellular approaches to discover how the >60 cell types of the retina choose their fates during development. The Cepko laborartory also has been working to develop gene therapy for prolonging vision in individuals who inherit disease genes leading to blindness. They are using AAV viral vectors to deliver genes that prolong the survival of rod and cone photoreceptors, the cell types that degenerate in most forms of blindness. Their current approach is to use these vectors to combat oxidative stress in photoreceptor cells. The Cepko lab is also developing viral vectors for tracing neuronal circuitry. They have adapted the vesicular stomatitis virus (VSV) to enable the definition of cells that are synaptically connected. VSV transmits from one cell to the next only via synapses and they are exploiting this property to make vectors that work across many species to define microcircuits. They are also developing methods that use the green fluorescent protein (GFP) to regulate biological activities, as well as nanobodies that regulate biological activities in cells that express particular antigens.
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