FOR SIGHT Annual Report 2013

1 CONTENTS

SIMPLYThe UC San Diego Department of Ophthalmology WORLDat the Shiley Eye Center is the only academic eyeCLASS center in the region offering the most advanced treatments across all areas of eye care. Our world class clinicians, surgeons, scientists and staff are dedicated to excellence CHAIR, DEPARTMENT OF OPHTHALMOLOGY Robert N. Weinreb, M.D.

and providing the best possible patient care to prevent, treat and cure eye diseases. Our research is at the forefront of developing new EDITOR methods for diagnosis and treatment of eye diseases and disorders. In addition to educating the leaders of tomorrow, we are committed Bobby S. Korn, M.D., Ph.D. CONTRIBUTORS to serving the San Diego and global community. Jean-Paul Abboud, M.D., Ph.D. Jo Adamcik Natalie A. Afshari, M.D. Radha Ayyagari, Ph.D. Dirk-Uwe Bartsch, Ph.D. Letter From Our Chairman Ophthalmology Education John Cerda 04 42 Napoleone Ferrara, Ph.D. Henry A. Ferreyra, M.D. William R. Freeman, M.D. Lilian Gischler Jeffrey L. Goldberg, M.D., Ph.D. Clinical & Research Highlight Stories Publications, Lectures, Clinical Trials & Grants David B. Granet, M.D. 06 44 Weldon W. Haw, M.D. Debra Kain Don O. Kikkawa, M.D. Craig Kishaba Scott LaFee Faculty Giving Opportunities Jack Li 18 66 Felipe A. Medeiros, M.D., Ph.D. Shereen Nourollahi Karen Anisko Ryan, M.S. Kelly Todd Optometry & Low Vision Donor Stories Linda Zangwill, Ph.D. 37 68 CREATIVE LJG Partners PHOTOGRAPHY Fellowships & Residency List of Donors Melissa Jacobs/sandiegophoto.com 38 72 Tim Mantoani Photography Chris Park Photography Carol Sonstein Photography Stephen Whalen Photography Shiley - Year In Review PRINTING 2 41 Tu’s Printing & Graphics 3 Colleagues, friends, alumni and supporters,

I am pleased to share highlights of the 2012-2013 and the Laboratory for Visual Performance Summary year in this second Annual Report. We are proud (Felipe Medeiros, M.D., Ph.D.). At the Shiley Eye Center, we seek to cure to bring to you the achievements and news of and prevent blinding eye diseases through our outstanding faculty, residents, fellows and Napoleone Ferrara, M.D., a world-renowned multi-disciplinary cooperation and teamwork staff, as well as their clinical contributions, scientist for his translational work with in research, education, community service research discoveries and service to the angiogenesis and macular degeneration, and clinical care. community and profession. was appointed to our faculty. With high expectations for preserving and Patient Care At the 2013 Annual Meeting of the Association improving the vision of our patients, we also Ten of our full time clinical faculty were named for Research in Vision and Ophthalmology are inspired by our aspirations for improving A LETTER FROM to the U.S. News & World Report “Top Doctors” (ARVO), our Department had its most visible their lives. 2013 listing. All major specialties are represented presence yet with over 66 presentations and among our faculty with several being recognized posters from our faculty, residents and fellows. On behalf of our team, I thank you for your as being the top 1% in the nation. generous support and encouragement. OUR CHAIRMAN Education Natalie Afshari, M.D., who joined our faculty this We have accelerated our continuing medical year, has established a new clinical program for educational offerings with a monthly ROBERT N. WEINREB, M.D. patients with ocular surface disease. Ophthalmology Community Lecture Series. Internationally renowned clinicians and Chairman and Distinguished Professor of Ophthalmology Research scientists joined us monthly during the past year Robert N. Weinreb, M.D. Director, Shiley Eye Center During the past year, many faculty received honors, updating practitioners in San Diego and Imperial Chairman and Distinguished Professor Director, Hamilton Glaucoma Center awards and research grants. The Department’s Counties on the latest in ophthalmic care. of Ophthalmology national ranking of total National Institutes of Director, Shiley Eye Center Morris Gleich, M.D. Chair of Glaucoma Health (NIH) research funding has risen from In February, the Department hosted its annual Director, Hamilton Glaucoma Center #12 to #7 (ranked by Blue Ridge Institute for “Ophthalmology Update” with 300 attendees. Morris Gleich, M.D. Chair of Glaucoma Medical Research.) At the beginning of the weekend, a special Alumni Grand Rounds was held with the annual With additional innovative research funded by Stuart I. Brown Lecture delivered by Shiley non-governmental organizations and private Eye Center alumnus, Christopher Leung, M.D., donors, new research initiatives include our Professor of Ophthalmology, Chinese University Ocular Biobank (Linda Zangwill, Ph.D. and Radha of Hong Kong. Ayyagari, Ph.D.), the Laboratory for Regenerative Ophthalmology (Jeff Goldberg, M.D., Ph.D.),

4 5 “The Visual Performance develop strategies for prevention and rehabilitation”, Lab will provide a clinical said Dr. Medeiros. research environment to Most ocular diseases can impair promote a comprehensive the ability to drive. The laboratory NATIONAL EYE INSTITUTE assessment of functional currently houses an open-cockpit performance in different simulator for driving assessment, but is expanding soon into a ophthalmic conditions” high-fidelity full cab simulator that GRANT TO STUDY GLAUCOMA will help researchers understand laucoma is the leading cause of blindness how different eye conditions in African-Americans. It is four to five times - Dr. Felipe Medeiros affect the ability to drive under more likely to occur in persons of African realistic scenarios, such as descent, and up to 15 times more likely night driving, or to simulate IN AFRICAN-AMERICANS to cause meaningful visual impairment challenging situations such as in this group compared to those glare. In addition to driving assessment, the laboratory will house a 3-dimensional of European descent. G CAVE, an immersive virtual reality environment where patients will be able to perform several tasks designed to replicate daily activities. “The 3D virtual A study led by Robert N. Weinreb, M.D., Chairman and reality environment allows us to perform controlled experiments that will provide Distinguished Professor of Ophthalmology at the Shiley insight into how patients and healthy subjects perform daily activities, such as Eye Center, received $6.4 million in grant funding visual search”, Dr. Medeiros said. By incorporating devices able to monitor eye over five years from the National Eye Institute (NEI) movements, known as eye-trackers, the laboratory will also allow researchers beginning in 2013, to study the relationship between to investigate adaptation mechanisms employed by patients under different genetics and progression of glaucoma in persons of conditions of visual function loss. African descent.

As part of his research in the laboratory, Dr. Medeiros has recently been Dr. Weinreb has teamed with Jerry Rotter, M.D., selected as a “Google Developer”, and has been given the opportunity to Distinguished Professor of Pediatrics, Medicine work with the Google Glass before it is available for public use. “The Google and Human Genetics at Harbor-UCLA Medical Center, Glass is an innovative and exciting device that will allow us to study visual a renowned genetics expert, to identify glaucoma function within a mobile platform”, he says. “Linking the visual stimuli presented genes in this high-risk, minority population. Its aim is by the Google Glass with objective ways to monitor brain function, such as to develop predictive models for glaucoma diagnosis electroencephalogram (EEG), can potentially give us new ways to monitor visual and progression, as well as the discovery of new drug NEW VISUAL PERFORMANCE impairment at distance without the need for patients to come to the office for targets for therapies to reduce the visual impact of testing. This would be truly revolutionary”, he adds. In this endeavor, Dr. Medeiros glaucoma blindness. has partnered with Scott Makeig and Tzyy Ping Yung, Director and Associate Director, respectively, of the Swartz Center for Computational Neuroscience “A better understanding of how genetics influences at UCSD. the rate of worsening of glaucoma is needed to better LABORATORY AT SHILEY manage and prevent blindness in this high-risk group,” The Performance lab will be available for cross-specialty studies, with the goal of stated Linda Zangwill, Ph.D., Professor of conducting studies and clinical trials in glaucoma, retina, neuro-ophthalmology, Ophthalmology at the UC San Diego, state-of-the-art Visual Performance Laboratory is being created at the pediatrics, cornea and oculoplastics. “Dr. Medeiros’ research is unique and and co-investigator of the study. Department of Ophthalmology of the University of California San Diego (UCSD). “The Visual Performance Lab will provide a clinical research transformative and directly benefits our patients. The substantial array of technologies housed in his laboratory is an extraordinary resource for researchers In addition to the research conducted at the Shiley Eye environment to promote a comprehensive assessment of functional at UCSD and their collaborators from throughout the world,” said Robert N. Center, the recruitment, enrollment and phenotyping performance in different ophthalmic conditions”, said Felipe Medeiros M.D., Weinreb, M.D., Chairman and Distinguished Professor of Ophthalmology. will take place at the New York Eye and Ear Infirmary Ph.D., Professor of Ophthalmology at UCSD and Director of the Laboratory. (Jeff Liebmann, M.D.), a private practice in Atlanta and “It is essential that we understand how our patients are affected in their Aabilities to drive, walk, read or perform other everyday activities. This will help us (above) Dr. Medeiros conducting experiments using the eye tracking the University of Alabama at Birmingham (Christopher and virtual reality at the new Visual Performance Laboratory 6 Girkin, M.D., M.S.PH.) 7 These samples will be utilized to learn about predictors of diseases (biomarkers), effectiveness or lack of effectiveness of therapies, understand disease pathologies and developing effective therapies.

According to Dr. Ayyagari, “Within the Shiley BioBank, the entire process of banking the collected data and physical samples has been streamlined utilizing a systematized and state- of-the-art secure electronic database with tools.” Demographic, ethnic, medical and risk factor history data are collected from patients on iPads; details of sample collection, processing, analysis and exact freezer storage location of samples are recorded in the BioBank database system. Each step of the process ensures that all patient data and samples are stored, tracked, and readily available to share with investigators, along with all linked clinical, demographic, genotype, and phenotype information while maintaining strict confidentiality protocols. The protocol that has been approved by the UCSD Institutional Review Board Committee includes all activities including emarkable progress has been made development of new treatments and therapeutic the sample collection, sample processing and in the past few years in the field of methods through genomic medicine, have drawn intended use and handling protocol. ophthalmology. These advances attention to “Biobanking”, enabling researchers include development of novel tools to readily utilize advances in the field. The Shiley Eye Center BioBank will serve as a for phenotype evaluation, identification reference library for each patient. With readily of more disease causing genes, better Under the direction of Radha Ayyagari, Ph.D., available sample collection, it presents numerous understanding of pathology, and the Associate Professor of Ophthalmology, and Linda opportunities for investigators to analyze existing Rdevelopment of new treatments including gene Zangwill, Ph.D., Professor of Ophthalmology, the data and conduct additional studies based on therapy and design of drug delivery modalities. Shiley Eye Center initiated its BioBank last year the most recent scientific knowledge. Robert N. All of these call for further research and with the goals of building a resource of readily Weinreb, M.D., Director of the Shiley Eye Center, integration of research results into clinical practice available biological samples, with complete believes that “In the future, the BioBank will to enable better patient care and prognosis. medical and family history and demographic enable investigators to learn about predictors information to accelerate research to prevent of eye disease, treatment effectiveness and The recent surge in biological sample banking is blindness. The staff of the BioBank has been disease pathology, as well as provide critical new partially due to the advances in understanding collecting blood, tissue, and biological fluid information for developing innovative treatments the biology of diseases and the promise of samples from patients with ophthalmic diseases. to prevent and cure blindness of macular personalized medicine. The addition of new In addition, sophisticated methods are employed degeneration, glaucoma and other blinding bioinformatics technologies and the availability to derive induced pluripotent stem cells from eye diseases.” SHILEY EYE CENTER BIOBANK of next-generation sequencing tools, as well as specific individuals for storage in the BioBank. A KEY TO PRESENT AND FUTURE RESEARCH TO PREVENT BLINDNESS

8 9 ngiogenesis involves the growth the function of VEGF might deny tumors and of new blood vessels, a process wet AMD the sustenance needed to grow and elemental to developing and spread. Ferrara and colleagues followed up with sustaining life and health. But there’s development of a humanized anti-VEGF antibody, a dark side as well: some cancers the basis of the drug bevacizumab (Avastin), exploit angiogenesis to feed tumors which has been approved for treatment of some and spread disease. The phenomenon forms of colorectal, lung and renal cancer, and Ais not limited to just cancer. subsequently used by ophthalmology for treating NEW TREATMENTS AMD and other retinal vascular diseases. Age-related macular degeneration (AMD) is FOR MACULAR DEGENERATION the leading cause of blindness in older adults. He also was focused on AMD, developing in his There are two forms: “Dry” occurs slowly over lab another anti-VEGF antibody fragment called time as portions of the retina atrophy. “Wet” ranibizumab (Lucentis) as a potential therapy for is less common, but far more devastating. It is wet AMD. In 2006, the therapy was approved caused by abnormal, leaky blood vessel growth. after multiple clinical trials showed substantial While less than 20 percent of AMD cases are wet, visual acuity gains in patients with severe cases. they account for 80 to 90 percent of severe vision Ranibizumab has since been approved for treating loss. Each year, roughly 200,000 new cases of retinal vein occlusion and diabetic macular edema wet AMD diagnosed in the United States. as well as wet AMD.

Both growing cancer tumors and wet AMD rely “This work has been extremely gratifying,” said upon angiogenesis, but it was not until the 1990s Ferrara, who continues to pursue AMD studies at and research by Napoleone Ferrara, M.D., that the UC San Diego Shiley Eye Center. “I’m humbled science was able to pinpoint the “X factor” that by the magnitude of the benefit, particularly the drives vascular growth, providing for the first time improved vision in patients, which exceeded my a therapeutic target for both cancer and AMD. expectations, considering that previous treatments only slowed down the rate of vision loss.” Dr. Ferrara was appointed during the past year as a Distinguished Professor of Ophthalmology In 2010, Dr. Ferrara won the prestigious Lasker- and Pathology at the UC San Diego School of DeBakey Clinical Medical Research Award, often Medicine as well as the senior deputy director called the American Nobel Prize, for the discovery for basic science at UC San Diego Moores Cancer of VEGF as a major mediator of angiogenesis Center. In the 1980s, Ferrara, who had trained and the development of an effective anti-VEGF at the University of Catania Medical School in therapy for wet AMD. Most recently in February of Italy, was working as a postdoctoral fellow at this year, he received the inaugural Breakthrough the UC San Francisco Medical Center, when he Prize in Life Sciences for his discoveries in the identified a protein that selectively promoted the basic mechanisms of angiogenesis that led to growth of vascular endothelial cells – the cells novel therapies for cancer and eye diseases. that line the entire circulatory system, from the heart to the smallest capillaries. In 1988, he joined (middle) Retina vessels, courtesy of I. Kasman and the South San Francisco-based biotechnology W. Ye, Genentech company Genentech. Ferrara and his colleagues at Genentech were able to isolate and clone this angiogenic molecule and termed it “vascular endothelial growth factor” or VEGF.

The discovery of VEGF proved a monumental advance. Since the protein was vital to growing blood vessels, researchers theorized that blocking 10 11 adhan Brown has always loved baseball. He is protecting his brain and sinuses. In the end, he was able to considered one of the top young prospects in piece together this complex orbital jigsaw puzzle and return all of San Diego County. As a thirteen year old, the eye to full movement. he pitches up to 75 mph as well as playing 1st and 3rd base. He is the starting pitcher for the Initially, Cadhan had significant edema at the surgery site Encinitas Little League All Stars. In 2011 and 2012, and still had double vision. But with each passing day, he led the Encinitas Little League in home runs his swelling started to resolve and his eye movements andC was the Home Run Derby Winner in 2012. Despite the continued to improve. Amazingly eye muscle surgery to get hours he spends each day practicing, Cadhan carries a 4.0 rid of double vision was not needed and Cadhan’s eye healed GPA, and was named Encinitas Chamber of Commerce beautifully. At two months out, Drs. Korn and Granet gave Student of the year. Even more amazing, is that Cadhan Cadhan the clearance to start baseball practice again and is a type I diabetic and manages to compete at such an he hasn’t looked back since! “We are eternally grateful elite level in his sport. of the care given to Cadhan by Dr. Korn and Dr. Granet,” said his parents. Despite playing multiple positions, Cadhan’s love is pitching and dreams of one day pitching in the major leagues. All This accident brings awareness to the importance of using of this came to a sudden halt in early 2013. In less than a protective eye gear by children and adults as standard second, the average time it takes a baseball to reach the equipment for a variety of sports activities. According to the pitcher’s mound after the batter strikes the ball, Cadhan was National Eye Institute (NEI), most sports-related eye injuries struck in the eye socket by a line drive. Worried about their can be avoided with the use of protective eyewear such as child, loss of his budding baseball career and worse yet maybe safety glasses and goggles, safety shields, and eye guards even blindness, Cadhan’s parents searched for a place they for a particular sport. Ordinary prescription glasses, contact could get help. Hours from home they came down the freeway lenses and sunglasses do not protect against eye injuries. and started making phone calls. He was rushed to see David Safety goggles should be worn over them. B. Granet, M.D., Director of the Ratner Children’s Eye Center at the Shiley Eye Center. Hearts pounding the family was At the Shiley Eye Center, ophthalmic subspecialists are all relieved that his eye was ok after Dr. Granet’s examination. housed in one complex. “The beauty of this place is that However, a CT scan showed the baseball had shattered we have world-class eye doctors right next to each other. the majority of the bones in Cadhan’s eye socket (orbit). Our patients receive the benefit of a team of multiple The fracture also involved the upper wall of the orbit with a ophthalmic specialists putting their heads – and hands – bone fragment just millimeters away from entering Cadhan’s together,” said Dr. Granet. “That teamwork, on the field or brain. To compound matters, the injury was causing restricted in medicine, produces the best results” continued Granet. eye movements and left him with double vision. Collaboration amongst physicians in all of the ophthalmic divisions is a hallmark of the Shiley Eye Center and enables Dr. Granet immediately brought Cadhan over to the adjacent our patients to receive the highest level of care. Shiley Eye Center to see Bobby Korn, M.D., Ph.D., Associate Professor of Clinical Ophthalmology in the Ophthalmic Plastic and Reconstructive Surgery Division. Dr. Korn reviewed Cadhan’s CT scans. Their stomachs ached when Dr. Korn talked about Cadhan’s shattered orbit. Would he ever be normal again? Could he drive? Go to school? Ever play baseball? Calmly Dr. Korn discussed all of the options. “We are eternally grateful of Almost certainly they included bone work to piece together SHILEY DOCTORS the orbit and likely eye muscle surgery. In the operating room, the care given to Cadhan by Dr. Korn meticulously realigned all the bone fragments and Dr. Korn and Dr. Granet,” covered each of the fractures with implants and screws while said Cadhan’s parents. 12 SAVE PITCHER’S EYE 13 “I was postponing Ophthalmology, checked his HOW DOES ALL OF THIS RELATE TO SMARTPHONES? eyes during different times of this surgery because Most recently, Dr. Afshari and her team have MATHEMATICAL ALGORITHM FOR THE SMARTPHONE the day and noted a significant developed a smartphone application to be utilized I didn’t know what difference. It was clearly time by physicians for predicting the refractive shift APPLICATION TO PREDICT POST-DSAEK REFRACTIVE SHIFT to expect, but I was to plan for DSAEK (Descemet’s (correction needed with eye glasses or lens automated endothelial implant) in patients’ eyes after DSAEK. Although pleasantly surprised keratoplasty) surgery, which this surgery often produces excellent visual Figure 1 and very glad to is a partial thickness corneal outcomes and rapid recovery, patients also transplant surgery. Mr. Briney commonly experience some change in refraction finally see clearly.” was unsure about having surgery in the transplanted eye - usually becoming slightly but he had faith in Dr. Afshari. more far-sighted. Recently, Dr. Afshari developed To his relief, the surgery was - Lester Briney a mathematical model and formula for predicting painless and successful. After this change in vision after DSAEK surgery his surgery, he opened his eyes based on measurements of the patient’s eye to see the world as though it was and the transplant tissue made before surgery. in “high definition.” Mr. Briney Because this formula is cumbersome to calculate admitted, “I was postponing this surgery because I didn’t know what to expect, manually, she and her team developed a smart but I was pleasantly surprised and very glad to finally see clearly.” phone application to allow corneal surgeons to select the optimal lens implant for clearest Fuchs endothelial corneal dystrophy is one of the leading reasons for ~ 40,000 vision. Smartphones are everywhere, even in FUCHS DYSTROPHY corneal transplants that are performed annually in the United States. It causes the operating room these days. “I hope that FROM GENETICS TO SMARTPHONE APP decreased vision as a result of endothelial cell loss and corneal swelling. our smartphone App helps accuracy of surgical Cornea endothelial cells, comprising the innermost layer of the cornea, are cells outcomes for patients around the world” that pump fluid out of the cornea and keep it clear. A significant reduction in says Dr. Afshari. the endothelial cell density results in insufficient pump function required for the cornea to stay clear and dehydrated. This causes the cornea to become In each version of the application, the user will swollen, compromising transparency, and leading to a decrease in visual acuity. be asked to input the patient’s preoperative ester Briney is a successful engineer and entrepreneur. He has his own central corneal thickness in micrometers, company and is Chief Technology Officer (CTO) of another. His work was FUTURE THERAPY the patient’s preoperative posterior radius of getting harder because his vision steadily declined over a decade. The truth is curvature in millimeters, the corneal transplant’s Dr. Afshari has been studying the genetics of Fuchs Corneal Dystrophy for over Figure 2 that he has Fuchs Corneal dystrophy, a degeneration of the inner cell layer of central graft thickness in micrometers, and finally a decade and has collected over 1500 patients’ DNA sample with this disease. the cornea (the clear tissue in the front of the eye). As the CTO of a company the corneal transplant’s graft central-peripheral With colleagues, great strides have been made in pinpointing areas of the developing video technology, this made it difficult to see if the product was thickness ratio in order to calculate the genome responsible for this disease. They have also been developing new functioning well or not. Working in the mornings soon became impossible post-DSAEK refractive shift. options for treatment of Fuchs Endothelial Dystrophy. Her colleagues Dr. Lbecause this was the time when his eyesight was at its worst. He could not drive to work Shigeru Kinoshita and Dr. Noriko Koizumi from Kyoto, Japan have worked on a until noon. His failing eyesight was not only a difficulty in his work, but a detriment to his type of molecule called ROCK inhibitor as a potential agent for division of the life. As if it was not bad enough, the additional progression of cataracts nearly put his eyes (right top) Figure 1: Published in Investigative corneal endothelial cells. Dr. Afshari has also worked on developing eye drop out of commission. Ophthalmology and Visual Science (Refractive medications as opposed to surgical treatment for Fuchs corneal dystrophy. changes after descemet stripping endothelial Topical administration of ROCK inhibitors in animals has demonstrated marked keratoplasty: a simplified mathematical model. He decided it was time to get to the bottom of his vision decreasing. Being an engineer, reduction of corneal swelling in treated eyes. “For the future, my hope Hwang RY, Gauthier DJ, Wallace D and Afshari NA.) he knew the importance of seeking expert advice. He took to the Internet in search of is to treat patients that have Fuchs with eye drops rather than surgery. help. He soon found Natalie Afshari, M.D., known for her research in Fuchs endothelial I believe this is achievable very soon” says Dr. Afshari. (right bottom) Figure 2: iPhone Application corneal dystrophy and clinical care of patients afflicted with it. At the time of his research, for Physicians Dr. Afshari had just been recruited to the UC San Diego Shiley Eye Center from Duke “Dr. Afshari’s research on Fuchs represents some of the most important University where she was Professor of Ophthalmology. Soon after walking into her new opportunities to make advances both in our fundamental understanding of Shiley Eye Center office last fall, she opened a letter already on her desk from Mr. Briney. corneal diseases, as well as in bringing new treatments forward” says Jeffrey Three days later, they were scheduling his first appointment. Goldberg, M.D., Ph.D., Director of Research and Professor of Ophthalmology at the Shiley Eye Center. 14 Dr. Afshari, as the new Chief of Cornea and Refractive Surgery and Professor of 15 effrey L. Goldberg, M.D., Ph.D., who joined the UC Eye Center, “Dr. Goldberg and his team enhance the ability San Diego Shiley Eye Center faculty in November of turning stem cells into retinal neurons that need replacing. 2012 as Professor and Director of Research in As a result, it is expected that patient treatments to rescue the Department of Ophthalmology, is directing and restore vision will be improved.” two exciting research programs. Each has great “The idea of restoring potential to restore vision to those who have lost Dr. Goldberg is optimistic and hopes to move these advances their sight, and are funded by both the National from the laboratory into clinical trials for patients. “We and vision in glaucoma EyeJ Institute and by private donations. others have developed good candidates that work well in is captivating and the laboratory, and plan to move toward human testing in very motivating,” One program involves developing regenerative therapies the near future,” Dr. Goldberg added. for glaucoma and other diseases of the optic nerve, like ischemic optic neuropathy (optic nerve stroke) or optic (left) Novel nanoparticle based therapeutics are being tested - Dr. Goldberg neuritis. In these diseases, optic nerve fibers that carry for their ability to enhance optic nerve regeneration in glaucoma and other optic neuropathies. visual information from the eye to the brain are damaged. Normally there is no regenerative response—that is why (right top) Retinal progenitor stem cells can be induced to the vision loss in glaucoma and other diseases has always differentiate into mature retinal ganglion cell like neurons that been thought to be permanent. may prove valuable in developing new treatments for glaucoma.

“The idea of restoring vision in glaucoma is captivating and very motivating,” Dr. Goldberg says. “We see so many patients with advanced disease and significant vision loss. Of course, there are too many more at risk of decline.” Dr. Goldberg’s group has been studying a recently discovered family of genes and proteins, the Kruppel-like transcription factors and their signaling partners, that control regeneration. They have discovered that increasing one or decreasing another can promote regeneration in experimental models of optic nerve degeneration.

The second program is designed to harness the potential of stem cell therapies for the eye. His group is studying how to replace degenerating retinal cells, particularly the rods and cones (photoreceptors) in macular degeneration, and the retinal ganglion cells in glaucoma, with cell replacement therapies. Although not yet ready for testing in patients, they have developed a number of innovative and potentially promising strategies for cellular regeneration. STEM CELLS FOR The first involves harvesting a patient’s adult retinal stem cells from their peripheral retina, growing them in the laboratory and reimplanting them back into the patient as retinal neurons (nerve cells).

Another approach involves turning stem cells into retinal neurons—his team uncovered a new set of molecules EYE DISEASE that controls how stem cells turn into retinal ganglion cells. According to Robert N. Weinreb, M.D., Director of the Shiley

16 17 DEPARTMENT OF OPHTHALMOLOGY

18 19 GLAUCOMA

Glaucoma can cause blindness if untreated and is the second leading cause of blindness in the United States. More than 3 million Americans have glaucoma and at least one half do not know it. Although there is no cure yet, loss of vision can be slowed or halted with medical and/or surgical treatment. The best way to protect your sight from glaucoma is to get tested. Early diagnosis and appropriate treatment are Robert N. Weinreb, M.D. Felipe A. Medeiros, M.D., Ph.D. Jeffrey L. Goldberg, M.D., Ph.D. Chairman & Distinguished Professor of Ophthalmology Professor of Clinical Ophthalmology Professor of Ophthalmology the keys to preserving vision. Director, Shiley Eye Center Medical Director, Hamilton Glaucoma Center Director of Research, Shiley Eye Center Director, Hamilton Glaucoma Center Morris Gleich, M.D. Chair of Glaucoma The UC San Diego Hamilton Glaucoma Center Medical School Medical School University of Sao Paulo Stanford Medical School offers comprehensive and unparalleled glaucoma Medical School diagnostic services with unique instrumentation Harvard Medical School Residency Residency University of Sao Paulo Bascom Palmer Eye Institute that is not yet available anywhere else. In addition to Residency standard optic nerve imaging and functional testing, University of California, San Francisco Fellowship Fellowship University of California, San Diego Bascom Palmer Eye Institute specialized programs are available including Fellowship Certification University of California, San Francisco Certification continuous measurement of 24 hour intraocular Board Certification in Ophthalmology Board Certification in Ophthalmology pressure, a dedicated sleep unit for glaucoma Certification Board Certification in Ophthalmology Special Interests Special Interests testing, anterior segment imaging, a dedicated Challenging glaucoma cases and new surgical Glaucoma surgery; Cataract surgery; Neuroprotection visual performance laboratory, objective perimetry Special Interests procedures; Cataract surgery; Advanced imaging analysis and regenerative ophthalmology; Stem cell and tissue for diagnosis and detection of glaucoma progression; engineering; Nanotechnology Glaucoma surgery; Optic neuropathy and the aging eye; Uveoscleral outflow; with pupillometry, swept source OCT for imaging of New techniques for intraocular pressure measurement; Imaging of optic disc and nerve fiber layer; Mechanisms of optic nerve Functional impairment in glaucoma; Prediction models the lamina cribosa and choroid as well as a visual damage; Neuroprotection in glaucoma; Drug delivery; Cataract surgery and risk assessment in glaucoma Notables performance laboratory with a driving simulator. 2012 Lois Pope Life Fellows Research Award; 2012 Society for Advancement of Chicanos and Native Notables Notables Americans in Science Travel Award; 2012-13 American Our glaucoma specialists are world renowned 2012, 2013 US News and World report Top Doctors (Top 1%); 2012, 2013 2013 Best Doctors in America; 2013 Loris and David Society of Cataract and Refractive Surgery Award; Cited in Woodward/White Best Doctors in America; 2012, 2013 Honorary Rich Lecture, University of Alabama; 2013 South 2012 Vanderbilt Symposium Travel Award; 2012 for their clinical and research excellence and offer Professor, Chinese University of Hong Kong; 2013 Advisory Board, State African Glaucoma Society Honorary Member; 2012 Margaret Whelan Scholarship Fund Travel Grant; Key Laboratory in Ophthalmology, Sun Yat-Sen University, Guangzhou; 2013 unique management programs for glaucoma through Iranian Society of Ophthalmology Recognition Award; 2012 Carl and Barbara Alving Award, Eastern Atlantic President, Pan American Glaucoma Society; 2013 Innovators Award, American 2012 Federal University of Sao Paulo Special Recognition Student Research Forum, “Most Outstanding Research clinical trials and innovative medical and surgical Glaucoma Society; 2013 Visiting Professor, Huazhong University of Science Award; 2012 American Academy of Ophthalmology Achievement for the Year”; 2013: University of Illinois and Technology, Wuhan, China (2013-2016); 2012, 2013 President, American (AAO) Glaucoma Subspecialty Day Planning Group; 2012 Chicago, Cless “Best of the Best” Award; 2012: ARVO therapies that include genetic testing and Glaucoma Society Foundation; 2013 Honorary Member, Societe Francaise Member of the AAO BSCS Committee; 2012 Member of Cogan Award; Hope for Vision Scientist of the Year; regenerative ophthalmology. D’Ophtalmologie; Heed Ophthalmic Foundation Award; Past-President, the Research Committee, American Glaucoma Society; Association for Research in Vision and Ophthalmology Association for Research in Vision and Ophthalmology; Past-President, World World Glaucoma Association Research Award; Ronald David G. Cogan Award; American Society for Clinical Glaucoma Association; Ridley Medal; Past-President, American Glaucoma Lowe Medal; American Glaucoma Society Mid-Career Investigators; Research to Prevent Blindness Walt Society; Adjunct Professor, Chinese University of Hong Kong; Moecyr E. and Clinician Scientist Awards; Achievement Award and Lilly Disney Award; Heed Ophthalmic Foundation Alvaro Medal; Ronald Lowe Medal; World Glaucoma Association Founders American Academy of Ophthalmology; World Health Fellowship Award; Association of University Award; Leydhecker-Harms Medal; Lifetime Achievement Award American Organization (WHO) Committee for Prevention Professors of Ophthalmology Research Forum Academy of Ophthalmology; Watson Medal of Cambridge University; of Glaucoma Blindness; Member, Glaucoma Winner; Thermo Fisher Cellome Award; 20 Research Society Best Housestaff Teaching Award 21 Christopher Bowd, Ph.D. Andrew D. Huberman, Ph.D. Won-Kyu (Daniel) Ju, Ph.D. James D. Lindsey, Ph.D. John H.K. Liu, Ph.D. Peter Rosen, M.D. Rigby Slight, M.D. Linda Zangwill, Ph.D. Research Scientist of Ophthalmology Assistant Professor of Neurosciences/ Associate Professor of Adjunct Professor of Ophthalmology Adjunct Professor of Ophthalmology Associate Clinical Professor Associate Clinical Professor Professor of Ophthalmology in Residence Director, Center-based Visual Field Neurobiology/Ophthalmology Ophthalmology Director, Glaucoma Molecular Pharmacology of Ophthalmology of Ophthalmology Co-Director of Clinical Research, Assessment Center Laboratory Hamilton Glaucoma Center Co-Director, Center-based Imaging Data Graduate School Director, Hamilton Glaucoma Center Data Evaluation and Analysis (IDEA) Center Graduate School University of California, San Diego Medical School Medical School Graduate School Coordinating Center University of California, Davis The Catholic University in Korea (Masters & Ph.D.) Graduate School SUNY Downstate Medical Center University of Oklahoma; Internship at UCLA Postdoctoral Fellowship National Tsing Hua University Postdoctoral Fellowship Graduate School Postdoctoral Fellowship University of California, San Diego (M.S. Molecular Biology) Residency Residency Graduate School Washington State University Stanford University School of Medicine Manhattan Eye, Ear & Throat Hospital, University of Southern California Washington University in St. Louis Texas A&M University Harvard School of Pubic Health (M.S.) Sanford-Burnham Medical Research Institute Cornell University Postdoctoral Fellowship Special Interests (Ph.D. Pharmacology) Certification Ben-Gurion University of the Negev (Ph.D.) Special Interests Biology of optic nerve, experimental models of University of California, San Diego Postdoctoral Fellowship Certification Board Certification in Ophthalmology Postdoctoral Fellowship Retinal development and retinal ganglion cells Special Interests glaucoma, and aqueous humor dynamics Board Certification in Ophthalmology Harvard Medical School Mechanisms for neuroprotection and University of Waterloo, Waterloo, Ontario, Canada Special Interests Special Interests Notables neurodegeneration in glaucoma; Oxidative Early detection and monitoring of glaucoma; stress and glutamate excitotoxicity in glaucoma; Notables Special Interests UCSD sleep study comparing the effects of Pew Biomedical Scholar Award (2013-2016); Outstanding Poster Presentation, World Glaucoma Special Interests Special Interests Machine learning classifier analyses of imaging Mitochondrial dynamics, bioenergetics and Establishing the connection between visual investigational eye drops; UCSD Diagnostic McKnight Neuroscience Scholar Award (2013-2015) Regulation of intraocular pressure and ocular blood To improve our understanding of the complex and visual function measurements Congress, Vienna, Austria performance and task performance in all areas of Innovations in Glaucoma Study; Clinical dysfunction in retinal ganglion cell (RGC) and flow; 24-hour sleep laboratory for glaucoma and relationship between structural and functional eye disease; Psychophysics of visual performance; research in glaucoma; UC San Diego Optic optic nerve head (ONH) astrocyte in glaucoma; other eye diseases change over time in the aging and glaucoma eye; Use of the driving simulator as a methodology Disc Reading Center Mitochondria-related gene therapy for RGC and To develop computational and statistical techniques for evaluation on the relationship between visual ONH astrocyte neuroprotection in glaucoma to improve glaucomatous change detection, reduce performance and task performance; Connection the number of visits and optimize the type of testing between visual performance and task performance required; To identify risk factors that can predict in all areas of eye disease; Psych-physics of glaucomatous progression and rapidly progressing visual performance; Use of driving simulator as glaucoma a methodology for evaluation on the relationship of visual performance and task performance Notables Notables Glaucoma Research Society (elected member); Achievement Award American Academy of Outstanding Physician Award Ophthalmology; Association for Research in Vision and Ophthalmology Silver Fellow; Glaucoma Societies; Achievement Award American Academy of Ophthalmology; Association for Research in Vision and Ophthalmology Silver Fellow

22 23 RETINA AND VITREOUS

Diseases of the retina cause severe and debilitating vision loss. Our retina physicians diagnose and William R. Freeman, M.D. Michael H. Goldbaum, M.D. Radha Ayyagari, Ph.D. Dirk-Uwe Bartsch, Ph.D. Lingyun Cheng, M.D., Ph.D. Henry A. Ferreyra, M.D. Vice Chairman and Distinguished Professor Professor of Ophthalmology In Residence Associate Professor In Residence Associate Adjunct Professor Associate Adjunct Professor Assistant Clinical Professor treat macular degeneration, of Ophthalmology Co-Director, Retina Division of Ophthalmology of Ophthalmology of Ophthalmology of Ophthalmology diabetic retinopathy, tumors, Director, Jacobs Retina Center Co-Director, Jacobs Retina Center Director, Ocular Pharmacology Co-Director, Retina Division inherited retinal disease, retinal Medical School Graduate School Medical School Tulane University School of Medicine (M.D.) Osmania University, Hyderabad, India Graduate School Medical School University of California, San Diego detachment, macular holes, and Medical School Stanford University (M.S.) University of California, San Diego Shanxi Medical University, China other important retinal diseases. Mount Sinai School of Medicine, New York Postdoctoral Fellowship Residency Residency Molecular Genetics at the National Eye Institute, Postdoctoral Fellowship Residency University of California, San Diego The Joan and Irwin Jacobs Retina Residency Tulane University School of Postgraduate NIH, Bethesda University of California, San Diego The First Teaching Hospital of Shanxi Medical Center houses research projects Lenox Hill Hospital, New York Medicine & U.S. Naval Hospital University, China Fellowship University of California, San Diego seeking to find solutions for Fellowship Fellowship Special Interests Special Interests Postdoctoral Fellowship University of California, San Francisco Cornell University Medical Center and Molecular genetics of macular and retinal Retinal Imaging; Scanning Laser Imaging - University of California, San Diego Certification people of all ages who suffer from (Uveitis & Immunology) New York Hospital dystrophy; Biological mechanisms underlying confocal/non-confocal; Optical Coherence Ideta Eye Hospital, Japan Board Certification in Ophthalmology retinal conditions. The clinical University of Southern California, Los Angeles retinal diseases; Age-related macular degeneration; Tomography (OCT); Indocyanine Green and (Vitreo-Retinal Surgery) Certification Diabetic retinopathy Fluorescein Angiography; Tomographic research center at the Jacobs Board Certification in Ophthalmology Reconstruction of the Posterior Poles Special Interests Special Interests Ocular drug delivery and vitreoretinal diseases Electrophysiology; Inherited disorders of the Retina Center enables patients to Certification Notables Board Certification in Ophthalmology retina; Age-related macular degeneration; benefit from the latest advances Special Interests Sybil B. Barrington Scholar Award; Lew R. Notables Diabetic retinopathy; Retinopathy of prematurity Surgical & medical treatment of the retina Wasserman Merit Award Association for Research in Vision and in diagnostic equipment and and vitreous; Macular degeneration; Pediatric Ophthalmology Gold Fellow, 2013; Achievement Special Interests Notables Complicated retinal detachment; Diabetic retina; Ocular tumors; Glaucoma informatics Award American Academy of Ophthalmology therapies. Researchers working in Outstanding Teaching Award retinopathy; Macular holes & age related the Center’s laboratories apply the macular degeneration Notables power of genetics and stem cell 2013 US News and World Report’s Top Doctors; research towards the treatment Notables 2013 San Diego Magazine Top Doctor; Senior 2013 US News and World Report’s Top Doctors; Achievement Award American Academy of blinding diseases. Best Doctors in America; Research to Prevent of Ophthalmology; Top Doctors, San Diego Blindness, Physician Scientist Award; Foundation Fighting Blindness Award; City of San Diego Mayor Award; American Academy of Ophthalmology; Editor’s Choice Lecture; America’s Top Ophthalmologists; ARVO Silver Medal Fellow; Professor of Ophthalmology (Hon.), Wenzhou Medical College, People’s Republic of China

24 25 CORNEA AND REFRACTIVE

Peter Shaw, Ph.D. Gabriel A. Silva, M.Sc., Ph.D. Kang Zhang, M.D., Ph.D. Jiagang “Jack” Zhao, Ph.D. Natalie Afshari, M.D. Associate Project Scientist Associate Professor of Bioengineering Professor of Ophthalmology Assistant Project Scientist of Ophthalmology Professor of Ophthalmology of Ophthalmology Associate Adjunct Professor Chief, Ophthalmic Genetics Chief, Division of Cornea and of Ophthalmology Refractive Surgery Jacobs Faculty Fellows Professor Graduate School Graduate School of Bioengineering Medical School Mount Sinai School of Medicine, New York McMaster University, Ontario, Canada Harvard Medical School/Massachusetts Institute Medical School of Technology (M.D./Ph.D. Program) Postdoctoral Fellowship Stanford Medical School Postdoctoral Fellowship Graduate School Salk Institute, La Jolla, California The Shiley Eye Center Cornea and University of California, San Francisco University of Illinois at Chicago (Ph.D.) Residency Residency University of Toronto (M.Sc.) Wilmer Eye Institute at Johns Hopkins University Refractive speciality is dedicated Massachusetts Eye and Ear Infirmary Special Interests to the health and functioning Special Interests Postdoctoral Fellowship Postdoctoral Fellowship Stem cell based approaches for retinal disease Fellowship Massachusetts Eye and Ear Infirmary Mechanistic study of retinal ganglion cell Northwestern University University of Utah School of Medicine modeling and treatment; Differentiation mechanisms of the cornea and combines differentiation and survival; Impact of genetics of retinal cell fate restriction from pluripotent stem and innate immunity on eye; Gene therapy using Certification cells; Regeneration of retinal neurons from unparalleled care, expertise, and Certification engineered antibodies; Role of oxidative stress Special Interests Board Certification in Ophthalmology Muller glia state-of-the-art equipment to Board Certification in Ophthalmology and its functional targets and therapies in macular Cell signaling and information processing in ensure the best experience for degeneration; Diabetic retinopathy; Inherited retinal biological cellular neural networks; Retinal Special Interests degenerations; Plasma biomarkers for eye diseases physiology; Neural engineering; Degenerative Special Interests Age related macular degeneration; Diabetic patients. Shiley offers treatments Fuchs Dystrophy; Cataract surgery; Corneal retinal disorders retinopathy; Inherited retinal degeneration for complex and high-risk corneal transplantation; Descemet’s stripping endothelial Notables keratoplasty (DSAEK); Intacs for keratoconus; Laser Cheng Scholar; Van Slyke Award Notables and external diseases, as well refractive surgery, including LASIK, LASEK/Advanced 2013 - Society for Neuroscience (SFN) 2013 annual Notables Surface Ablation, PRK, PTK, Surgical Burroughs Wellcome Fund Clinical Scientist as the most current vision meeting ‘Hot Topic’ abstract; 2013 - ‘Faculty of and medical diseases of cornea Award in Translational Research; NIH Director’s the Year’ award for undergraduate education; correction procedures. Transformative R01 Award; NIH K23 Mentored 2012 - Tau Beta Pi Engineering Honors Society; Clinician Scientist Award; Mentored Clinician Notables Beverley and Clarence Chandran Distinguished Scientist Award; Lew R. Wasserman Merit Award; Top 10 Women in Medicine Award 2012; Cornea Lecture, Duke University; Jacobs Faculty Fellows Charles Schepens Award for Excellence in Retina Subspecialty Day AAO Co-Director 2012; Cornea Society, Endowed Chair in Bioengineering; American Society Research; Stark Research Award in Ophthalmology; Board of Directors 2012-2013; Chief Judge for American of Mechanical Engineers (ASME) Y.C. Fung Young Knights Templar Eye Foundation Research Award; Society of Cataract and Refractive Surgery Scientific Investigator Award; Wallace Coulter Foundation First Bower Award Posters 2012 and 2013; CPE Cornea Fellows National Early Career Award Course Director 2012-2013; Leadership Development Program of American Academy of Ophthalmology 2012; 2013 US News & World Report Top Doctors (Top 1%); Best Doctors in America; American Academy of Ophthalmology Achievement Award; American Academy of Ophthalmology Secretariat Award; Councilor Emeritus American Academy of Ophthalmology; Co-editor Principles and Practice of Cornea; Research to Prevent Blindness Award; Heed Foundation Award 26 27 NEURO- OPHTHALMOLOGY

Stuart I. Brown, M.D. Weldon W. Haw, M.D. Chris W. Heichel, M.D. Peter J. Savino, M.D. Professor of Ophthalmology Clinical Professor of Ophthalmology Associate Clinical Professor Clinical Professor of Ophthalmology & Dr. Richard and Tatiana Lansche Chief of Ophthalmology at Veterans of Ophthalmology Neurosciences Chair of Ophthalmology Administration Medical Hospital Medical School Medical School Medical School Medical School Chicago Medical School University of Bologna School of Medicine University of Illinois Medical School University of California, Los Angeles School of Medicine Residency Residency Residency University of California, San Diego Neuro-ophthalmologists diagnose Georgetown University Medical Center Tulane Medical School Residency (Chief Resident) Stanford University School of Medicine and treat neuro-sensory disorders Fellowship Fellowship (Chief Resident) Fellowship including brain tumors, double University of Miami Massachusetts Eye and Ear Infirmary University of California, San Diego Fellowship vision, giant cell arteritis, ischemic Certification Certification Stanford University School of Medicine Certification optic neuropathy, optic neuritis, Board Certification in Ophthalmology Board Certification in Ophthalmology Board Certification in Ophthalmology Certification papilledema, pseudotumor cerebri, Board Certification in Ophthalmology Special Interests Special Interests Special Interests thyroid eye disease and visual field Myasthenia gravis; Optic neuritis, atrophy and Methods of improving the efficiency of eye care Corneal transplantations and keratoprosthesis (K-PRO); defects. Shiley Eye Center’s skilled neuropathy; Brain and nervous system tumors; delivery to pre-school age children throughout Special Interests Descemet’s stripping endothelial keratoplasty (DSAEK); Visual field defects; Degenerative, metabolic California; Corneal transplantation; Cataract surgery; Cornea transplantation; Descemet’s membrane endothelial keratoplasty ophthalmologists conduct diagnostic inflammatory & demyelinating diseases; Vascular Cataract surgery Refractive surgery/LASIK (DMEK); Anterior segment and iris reconstruction; testing and thorough evaluation while disorders Challenging and traumatic cataract surgeries; IOL surgeries, including reposition, exchange and sutured working with the referring physician Notables Notables IOLs; LASIK, PRK and Visian ICL; Advanced techniques Notables Heed Ophthalmic Foundation Award; US News & World Report’s Top Doctor; America’s 2012, 2013 U.S. News and World Report Top in laser & refractive surgery; Treatment of Keratoconus, to manage the condition or illness. McLean Medal, Cornell/Columbia University; Top Doctors Doctor (Top 1%); 2012, 2013 Outstanding including INTACS and Collagen CrossLinking; Outstanding Teacher Award Clinical Teaching Award, UC San Diego, Shiley Ocular surface tumors; Limbal stem cell transplantation; Eye Center; Life Achievement Honor Award, Corneal transplantations and keratoprostheses; American Academy of Ophthalmology; Honorary challenging cataract and IOL surgeries; LASIK, Intacs, Fellowship, The Royal Australian and New & Visian ICL; Advanced techniques in laser & refractive Zealand College of Ophthalmologists; George L. surgery; Keratoconus; Ocular surface tumors; Tabor, M.D. Award; Lifetime Member Awarded, Limbal stem cell transplantation Philadelphia Ophthalmology Club; New York State Sons of Italy Anton Banko Award; Golden Apple Notables Award, Best Teacher of the Year Award; One America’s Top Ophthalmologists; US News & World of the “Best 100 Ophthalmologists in America,” Report’s Top Doctor; San Diego Magazine Top Doctor; Ophthalmology Times; Beem Fisher Award, Chicago Outstanding Surgical Teaching; Outstanding Teacher Ophthalmological Society Award; America’s Top Ophthalmologists 28 29 OPHTHALMIC THYROID PLASTIC AND EYE CLINIC RECONSTRUCTIVE SURGERY The UC San Diego Thyroid Don O. Kikkawa, M.D., F.A.C.S. Bobby S. Korn, M.D., Ph.D., F.A.C.S. Eye Clinic began in 1997 Vice Chairman and Professor of Clinical Associate Professor of Clinical Ophthalmology as the first of its kind in Ophthalmology the nation. Thyroid Eye Chief, Division of Ophthalmic Plastic and Reconstructive Surgery Medical School Disease is a complex University of Texas, Southwestern Medical School (M.D. & Ph.D.) autoimmune disease Orbits. Eyelids. Face. Lacrimal Medical School that affects not only system. These are the domains of St. Louis University School of Medicine Residency University of California, San Diego (Chief Resident) vision but also causes Residency oculofacial plastic surgery. Birth pain and deformity. University of California, Los Angeles Fellowship defects, cancer, trauma and the University of California, San Diego Drs. Granet, Kikkawa aging process can all alter the Fellowship University of Wisconsin, Madison Certification and Korn have helped periorbital region. These surgeons Board Certification in Ophthalmology Certification hundreds of patients with rebuild, reconstruct, renew and Board Certification in Ophthalmology this disfiguring disorder make whole again. The UCSD Special Interests Aesthetic and reconstructive surgery (eyelid & face); and have published Division of Ophthalmic Plastic Special Interests blepharoplasty (eyelid lift surgery); Ptosis repair extensively on its and Reconstructive Surgery is an Oculofacial surgery - aesthetic and reconstructive; surgery; Asian/ethnic eyelid surgery (double eyelid Eyelid, lacrimal and orbital surgery; Thyroid eye surgery); Congenital birth defects; Thyroid eye characteristics internationally recognized leader disease - orbital decompression and eyelid surgery; disease – orbital decompression, eyelid retraction and treatment. in patient care, teaching and Craniofacial disorders involving the eyelids and repair, ocular oncology, ocular surface disease, orbits; Orbital and eyelid tumors management of eyelid & orbital tumors & cancers; research. Dr. Kikkawa and Dr. Endoscopic lacrimal (tear drainage) surgery; Korn have pioneered innovative Notables Cosmetic skin rejuvenation; Orbital stem cells 2013 - U.S. News and World Report Top Doctor operations and techniques that (Top 1%); 2012, 2013 – San Diego Magazine Notables have become the standard. Physician of Exceptional Excellence; President- 2012, 2013 - U.S. News and World Report Top elect American Society of Ophthalmic Plastic Doctor;2008-2013 - Star Recognition Award for and Reconstructive Surgery, Best Doctors in Highest Rated Instructional Course, awarded by America; Top Doctor, US News and World Report; the American Academy of Ophthalmology; 2012, Top Doctors San Diego; Lester T. Jones Award; 2013 – San Diego Magazine Physician of Marvin H. Quickert Award; ASOPRS Research Exceptional Excellence; Editorial Board EyeNet Award; American Academy of Ophthalmology Magazine, Editorial Board AAO BSCS Volume 7, Senior Achievement Award; Outstanding American Academy of Ophthalmology Achievement Teaching Award Award; ASOPRS Research Award; Marvin H. Quickert Award; Outstanding teaching Award; Editor, Video Atlas of Oculofacial Plastic and 30 Reconstructive Surgery Orbits. Eyelids. 31 PEDIATRIC OPHTHALMOLOGY AND ADULT EYE REALIGNMENT SERVICES

Preventing and treating vision loss and ocular David B. Granet, M.D., F.A.C.S., F.A.A.P. Shira L. Robbins, M.D., F.A.A.P. problems in children is the highest priority at the Professor of Ophthalmology & Pediatrics Associate Clinical Professor Ratner Children’s Eye Center. Dr. David Granet and Anne F. Ratner Chair of Pediatric Ophthalmology Educational Director of the Pediatric Director, Anne F. and Abraham Ratner Ophthalmology/Strabismus Division Dr. Shira Robbins are world-renowned specialists in Children’s Eye Center Director, Division of Pediatric Ophthalmology helping children with eye misalignments (strabismus), Medical School nystagmus, congenital diseases like pediatric cataracts Medical College of Pennsylvania Hospital Medical School and glaucoma, acquired problems from blocked tear Yale University School of Medicine Residency ducts to “lazy eye” (amblyopia) as well as trauma. Hahnemann University Hospital Residency From premature babies to teenagers, our team New York University Medical Center Fellowship (Chief Resident) University of California, San Diego & Naval ensures that each child seen at the family-oriented Medical Center Ratner Children’s Eye Center is given the attention and Fellowship Children’s Hospital of Philadelphia Certification personal medical care they deserve in a child-friendly Scheie Eye Institute Board Certification in Ophthalmology atmosphere. Adults with strabismus suffer from an old Certification childhood problem, trauma, or a condition causing eye Board Certification in Ophthalmology Special Interests Strabismus/eye misalignment/double vision; misalignment and require individualized intervention. Amblyopia; Retinopathy of prematurity; Pediatric Recognized worldwide for their teaching and Special Interests glaucoma & cataracts, including intraocular lens Pediatric ocular issues & strabismus; Adult eye misalignments; State- placement; Nasolacrimal duct disorders; Congenital developments in this field, the specialized surgeons of-the-art adjustable suture strabismus surgery; Nystagmus; Childhood eye syndromes; Craniofacial syndromes; Systemic at the Ratner Eye Center can help virtually everyone eye alignment disorders; Learning disorders & role of vision diseases affecting the eyes; Nystagmus – regardless of age – suffering from various ocular Notables Notables misalignments and their consequences. 2012, 2013 US News and World Report Top Doctors (Top 1%); 2012, 2013 US News and World Report Top 2012 Senior Honor Award, American Association for Pediatric Doctors; 2013 San Diego Magazine Top Doctors; Ophthalmology & Strabismus; 2013 Aurora Award for UCSD-TV Textbook Editor, AAP Challenging Cases in Pediatric show “Colon Cancer Screening”; 2013 San Diego Magazine Top Ophthalmology; Journal Section Editor, Current Doctors; Senior Achievement Award AAO; American Association Ophthalmology Reports; National Institutes of of Pediatric Ophthalmology Senior Honor Award; Chair-Elect AAP Health LRP Award for Clinical Research; Best Section of Ophthalmology; Best Doctors in America; Top Doctors Doctors in America in San Diego; Visiting Professor National University Singapore; Co- Founder World Congress of Paediatric Ophthalmology & Strabismus; Co-Editor AAP Case Studies in Ophthalmology; Co-Director AAO Pediatric Ophthalmology Subspecialty Day 2011; Bronze Telly Award; Gold Aurora Award; Emmy Award 32 33 COMPREHENSIVE OPHTHALMIC OPHTHALMOLOGY PATHOLOGY

Jeffrey E. Lee, M.D. Thao P. Nguyen, M.D. Jonathan H. Lin, M.D., Ph.D., F.C.A.P. Clinical Assistant Professor of Ophthalmology Assistant Clinical Professor of Ophthalmology Assistant Professor of Ophthalmology Residency Program Director Pathology, Cellular and Molecular Medicine The UC San Diego Comprehensive Medical School Ophthalmology division Medical School University of Oklahoma, Tulsa Medical School University of California, San Diego Columbia University College of Physicians & provides a variety of services Residency Surgeons (M.D. & Ph.D.) Residency University of Rochester - New York and ophthalmic evaluations that University of California, San Diego Ophthalmic pathology service Residency Fellowship screen and treat a wide range of focuses on diseases of the eye and Brigham Women’s Hospital (Anatomic Pathology) Certification University of California, San Diego ophthalmic conditions, including Board Certification in Ophthalmology its neighboring tissues. Precision Fellowship Certification University of California, San Francisco cataracts, ocular surface disorders, Board Certification in Ophthalmology diagnosis of diseases is provided by (Ophthalmic Pathology) glaucoma, diabetic retinopathy, Special Interests the ophthalmic pathology service. Orbital compartment syndrome in Burn patients; Certification conjunctivitis, blepharitis and Facial burns; Orbital trauma; Ocular manifestations Diseased tissues are examined Board Certification in Anatomic Pathology macular degeneration. Primary of HIV macroscopically, microscopically and eye care is provided for all types on the ultrastructural level. Advanced Special Interests Notables Ophthamic Pathology including pigmented ocular of conditions of the eye and 2013 UC San Diego Ophthalmology Outstanding genomic, proteomic, and cytogenetic lesions (uveal melanoma, primary acquired surrounding structures, both Teacher for Residents; and 2013 UC San Diego techniques can be utilized to diagnose melanosis), basal cell carcinoma, sebaceous Outstanding Teaching Award for Medical Students gland lesions, inflammatory lesions (sclerosing routine and urgent. Treatments diseases at a molecular level. The orbital inflammatory pseudotumor, IgG4 disease), offered vary from medications pathologic diagnosis of the disease MALToma, corneas (PKPs, DSAEKs), conjunctival biopsies (conjunctival intraepithelial neoplasia and glasses prescriptions; to laser plays a vital role in patient care. - CIN), orbital lesions, intraocular fine needle therapy, small in-office procedures aspirates/vitrectomy specimens; Cellular and molecular mechanisms of retinal degeneration; and more invasive surgical options. RPE and ocular stem cells.

Notables American Society for Investigative Pathology Ramzi Cotran Early Investigator Award; American Society for Investigative Pathology Ramzi Cotran Early Investigator Award; Karl Kirchgessner Foundation Vision Research Award; American Federation for Aging Research New Investigator Award; Hellman Family Foundation Jon I. Isenberg Fellow; Hope 34 for Vision Foundation New Investigator Award 35 RETINAL VASCULAR DISEASES

The regulation of angiogenesis is a pathological process that occurs in retinal vascular diseases such Napoleone Ferrara, M.D. Anne B. Ho, O.D. Pamela A. Hoo, O.D. Lara Hustana, O.D. John F. Kulischak, O.D. Lianne Mizoguchi, O.D. Jessica A. Tasto, O.D. Distinguished Professor of Ophthalmology as diabetic retinopathy and age- and Pathology related macular degeneration. Senior Deputy Director for Basic Sciences, UCSD Moores Cancer Center Vascular endothelial growth factor (VEGF) is the principle mediator in Medical School this complex disease process and in University of Catania Medical School, Catania, Italy OPTOMETRY 1989, our laboratory cloned this gene. Residency We have subsequently developed two University of Catania Medical School, Catania, Italy inhibitors of VEGF, bevacizumab and Fellowship & LOW VISION ranibizumab for clinical use. In 2006, University of California, San Francisco ranibizumab was approved for the Shiley Eye Center optometrists Special Interests are eye care professionals who treatment of wet AMD after multiple Regulation of angiogenesis (the formation of Phase III trials demonstrating that new blood vessels) and the role of VEGF (vascular perform comprehensive eye exams endothelial growth factor); Continue to develop new and are experts at fitting all types administration of such agent results therapies to treat age related macular degeneration in substantial visual acuity gains. building upon past development of Avastin® of contact lenses and glasses. and Lucentis®. Since 2006, the FDA has expanded Visual impairment from inherited diseases to diabetic retinopathy and the use of ranibizumab, approving it Notables to treat retinal vein occlusion in 2010 2010 Lasker Debakey Clinical Medical Research macular degeneration can result Award; 2012 Juvenile Diabetes Research in profound vision loss. Using the and diabetic macular edema in 2012. Foundation Award; 2012 The Economist Innovation Award (Bioscience); 2013 Elected Fellow and latest technological advancements Member of Council of Advisors to the American Association of Cancer Research Academy; Damon in optical aids, optometrists provide Runyon-Rachleff Innovation Award Committee much needed care for our low vision Member; North American Vascular Biological Organization Scientific Advisory Board Member; patients. Working hand in hand San Francisco State University Biology Program with Shiley ophthalmologists, the Advisory Board Member; 2012 Humanitas Clinical Institute Scientific Advisory Board Member; 2013 optometry service strives to deliver The Economist Innovation Award Jury Member; the best possible care to each patient. 2013 Breakthrough Prize in Life Sciences

36 37 Cornea Glaucoma Nikki Heidi Camara, M.D.* Akram Belghith, Ph.D. Bishoy Said, M.D. Daniel Freitas, M.D., Ph.D. Minh Vo, M.D. Na’ama Hammel, M.D. Maria Vola, M.D. Alex Huang, M.D., Ph.D. Naira Khachatryan, M.D., Ph.D. GLAUCOMA Tammy Kuang, M.D.* Ophthalmic Plastic and FELLOWSHIPS Renato Lisboa, M.D. Reconstructive Surgery Amir Marvasti Preamjit Saonanon, M.D.* Atsuya Miki, M.D. Richard Scawn, M.D. Myoung Sup Sim, Ph.D. Katherine Whipple, M.D. Shiley Eye Center offers world-class fellowships in cornea, glaucoma, ophthalmic plastic and reconstructive surgery, Andrew Tatham, M.D. pediatric ophthalmology, and retina. Fellows are exposed to intense training in both the clinical and research settings. Jonathan Tung, M.D. Siamak Yousefi, Ph.D. Pediatrics Many go on to prominent academic positions around the world as well as practicing as outstanding clinicians in the Chunwei Zhang, M.D. Brenda Breidenstein, M.D. global ophthalmic community.

* Not Photographed Retina Payam Amini, M.D. Cheryl Arcinue, M.D. Giulio Barteselli, M.D. Sharif El-Emam, M.D. Isaac Ezon, M.D. Huiyuan Hou, Ph.D. Chuanhong Jie, M.D.* CORNEA Azadeh Khatibi, M.D. Jun Kong, Ph.D.* Su-Na Lee, M.D., Ph. D. Yongchuan Liao, M.D.* Hongrong Luo, Ph.D.* RETINA Jing Luo, M.D., Ph.D. Feiyan Ma, M.D. Kaihui Nan, M.D.* Hong Ouyang, Ph.D. Bhubanananda Sahu, Ph.D.* Yang Yang, M.D.* Xiaohui Zhang, M.D.* Ling Zhao, Ph.D.

OPHTHALMIC PLASTIC & RECONSTRUCTIVE SURGERY PEDIATRICS * Not Photographed

38 39 39 PATIENT VISITS GRANTS SHILEY 109,774 $10.7 MILLION SURGERIES PERFORMED PUBLICATIONS 3,885 315

The UC San Diego Ophthalmology Residency Training FACULTY CLINICAL TRIALS Program is a three-year program with a total of 12 resident physicians (four per year of training). 1 2 3 4 5 6 7 8 9 10 RESIDENCY 35 63 Our highly selective residency program Glaucoma, Ophthalmic Plastic and such as the American Academy of receives over 400 applications per Reconstructive Surgery and Retina. Ophthalmology and the Association for From left to right: [1] Lilit Minasyan, M.D., [2] Elizabeth year from all over the country to fill four Research in Vision and Ophthalmology. YEAR IN Pinney, M.D., [3] Hema Ramkumar, M.D., [4] Cristiana Vasile, positions. It is known for its outstanding During their training residents learn, M.D., [5] Charlotte Gore, M.D., [6] Matthew Bedell, M.D., clinical and surgical training, as well as under the supervision of the renowned The UC San Diego Ophthalmology STAFF SHILEY EYE CENTER COMPLEX [7] Solomon Shaftel, M.D., Ph.D., [8] Jeffrey Liu, M.D. the value placed on scholarly activity Shiley faculty, to care for patients Residency Training Program was (Chief Resident 2012-2013), [9] Jean-Paul Abboud, M.D., and compassionate patient care. Our from all walks of life and with every recently recognized by the national Ph.D., [10] Kevin Tan, M.D. residents are among the brightest type of eye problem, from common to accrediting body, the Accreditation and most motivated, and continue to very rare eye conditions. In addition, Council for Graduate Medical SQ FT be high achievers during and after with Departmental support, residents Education, with a commendation 204 91,000 their training. As a result, graduating partake in the many cutting-edge on the excellence of the Residency residents are regularly chosen for research opportunities available in Program and its faculty. REVIEW competitive post-residency Fellowship the UC San Diego Department of training in various subspecialties Ophthalmology and present their of Ophthalmology, such as Cornea, work at pre-eminent national meetings

40 41 (left) Jeffrey (left) Natalie OPHTHALMOLOGY EDUCATION Goldberg, Afshari, M.D. M.D., Ph.D., and Robert N. (right) Don Kikkawa, OPHTHALMOLOGY COMMUNITY LECTURE SERIES December 17, 2012 May 13, 2013 OPHTHALMOLOGY UPDATE Weinreb, M.D. M.D., Christopher AND GRAND ROUNDS Christopher A. Girkin, M.D. Paul Sternberg, M.D., Ph.D. Girkin, M.D., Professor and Chairman, Department G.W. Hale Professor and Chairman The annual Ophthalmology Update was held and Robert N. of Ophthalmology Department of Ophthalmology Weinreb, M.D. The Department of Ophthalmology initiated February 16-17, 2013 at the Hilton Torrey University of Alabama, Birmingham School Vanderbilt University School of Medicine a new Community Lecture Series held the Pines, La Jolla. The event was a resounding of Medicine Title: “Biomarkers, Genetic Testing and AMD” first Monday of every month. The subjects success with almost 300 participants from Title: “Implications of Laminar Morphometry cover all areas of ophthalmology and the around the country. Don O. Kikkawa, M.D. on IOP-induced Optic Nerve Injury” June 10, 2013 Visiting Professor Lecturers include world and Robert N. Weinreb, M.D. served as Lee M. Jampol, M.D. (left) Isaac Ezon, (left) Don Kikkawa, renowned ophthalmologists. Continuing Program Co-Chairs. The interdisciplinary M.D., Payam M.D., James January 14, 2013 Louis Feinberg Professor of Ophthalmology medical education (CME) credits are faculty gave presentations on the latest Amini, M.D., Fleming, M.D., James C. Fleming, M.D. Northwestern University Feinberg School offered to attendees along with a reception surgical techniques, innovative ideas and Cheryl Arcinue, M.D., and Robert N. Philip Lewis Professor of Ophthalmology of Medicine immediately following the lectures. research in ophthalmology. The keynote William Freeman, Weinreb, M.D. Chairman, Department of Ophthalmology Title: “SD OCT Opens a New World of M.D., The lectures are held at the UC San Diego speaker, Napoleone Ferrara, M.D., joined the University of Tennessee, Memphis School White Spots” and Natalia (right) Natalie Moores’ Cancer Center in the Goldberg UC San Diego faculty this year. He updated of Medicine Camacho Afshari, M.D., Auditorium. the attendees on his transformative research Title: “Eyelid Lesions – Nasty or Nice?” Espinosa, Ph.D. Peter McDonnell, on VEGF and its applications in age-related M.D., and Robert The community also is invited to our Weekly macular degeneration. N. Weinreb, M.D. March 11, 2013 Grand Rounds every Monday. The Grand Peter J. McDonnell, M.D. Rounds consist of case presentations To kick off the Ophthalmology Update 2013, (left) Randall Olson, Director, Wilmer Eye Institute with moderated discussion. Interesting a special “Alumni Grand Rounds” was held at M.D., and Natalie William Holland Wilmer Professor eye diseases, treatment dilemmas and the UC San Diego Moores Cancer Center in ARVO WRAP UP Afshari, M.D. of Ophthalmology surgical challenges are often the theme. the Goldberg Auditorium. Alumni presenters Department of Ophthalmology (right) Shira Robbins, These are offered in the Shiley Eye included Drs. Rigby Slight, Mark Fay, After the May 5-9, 2013 Annual Meeting The Johns Hopkins School of Medicine Ray Gariano and Tommy Korn. This was of the Association for Research in M.D., William Center Conference Room. Freeman, M.D., Title: “Endophthalmitis: Why Isn’t It followed by the Stuart I. Brown Lecture Vision and Ophthalmology (ARVO) in Paul Sternberg, More Common?” 2012-2013 Visiting Professors: delivered by Christopher Leung, M.D. Seattle, Washington, the Department of M.D., Ph.D., Natalie Professor of Ophthalmology, Chinese Ophthalmology held an ARVO Wrap-Up Afshari, M.D., and April 8, 2013 (above) Napoleone Ferrara, M.D. and speakers November 19, 2012 University of Hong Kong (“The Continuum in the Shiley Eye Center Conference Don Kikkawa, M.D. Randall J. Olson, M.D. of the 2013 Ophthalmology Update Natalie A. Afshari, M.D. of Angle Closure Glaucoma”). Room. The Department had its most visible Professor and Chairman Professor and Chief, Division of Cornea presence yet with over 66 presentations (left) Don Kikkawa, CEO, John A. Moran Eye Center and Refractive Surgery and posters from our faculty, residents and M.D., Natalie Afshari, Department of Ophthalmology and M.D., Michael Department of Ophthalmology fellows which was among the highest in the Visual Sciences Goldbaum, M.D., UC San Diego School of Medicine world. The Wrap-up provided an opportunity University of Utah School of Medicine for medical students, residents, fellows and Lee Jampol, M.D., Title: “Flaps, Bubbles and Lasers: Recent Robert Title: “What Bothers Patients after faculty to hear and view the outstanding Advances in Cornea and Refractive Surgery” N. Weinreb, M.D., Successful Cataract Surgery” research that has been conducted in the William Freeman, Department during 2012-2013 as well M.D., and David as engaging the scientists in discussion Granet, M.D. about their projects.

42 43 PUBLICATIONS

Several Members of the Department of Ophthalmology have recently published textbooks that serve as standard references for ophthalmologists CORNEA July/August 2012; 10-13. factors for the development of retroprosthetic 1195-200. doi: 10.1016/j.ophtha.2012.11.025. membranes with Boston keratoprosthesis type Epub 2013 Mar 15. PMID: 23499061. worldwide. Some have been translated into multiple languages establishing Shiley’s global reach. Afshari NA, Minear MA, Rimmler J, Balajonda E, Hwang RY, Goldhagen B, Kuo AN, Afshari 1: multicenter study results. Ophthalmology. Watson S, Hauser MA, Allingham R, Klintworth NA. Changes in corneal biomechanics after 2012 May;119(5):951-5. doi: 10.1016/j. Daoud YJ, Munro AD, Delmonte DD, Stinnett GK, Li YJ, Gregory SG. Genetic screen of descemet stripping endothelial keratoplasty ophtha.2011.11.030. Epub 2012 Feb 22. S, Kim T, Carlson AN, Afshari NA. Effect of African-Americans with Fuchs endothelial A B in Fuchs dystrophy. Association for Research PMID: 22361316. Cornea Donor Graft Thickness on the Outcome corneal dystrophy. Association for Research in Vision and Ophthalmology (ARVO). 2012. of Descemet Stripping Automated Endothelial in Vision and Ophthalmology (ARVO). 2012. A: David B. Granet, M.D. and Shira L. Robbins, M.D. edited, Soler VJ, Tran-Viet KN, Fournie PR, St Germain Keratoplasty Surgery. Am J Ophthalmol. Kaufman HK, Haw W. Ganciclovir Ophthalmic E, Klemm TP, Hawthorne F, Afshari NA, Calvas 2013 Sep 4. doi:pii: S0002-9394(13)00445-5. “Challenging Cases in Pediatric Ophthalmology”. Afshari NA. Goals: strengthen, soothe, and Gel 0.15%: Safety and Efficacy of Ganciclovir P, Malecaze F, Young TL. Whole exome 10.1016/j.ajo. 2013.06.030. Epub ahead of print. save corneas. Rev Ophthalmol 2012; 5:46-55. B: Natalie A. Afshari, M.D. edited, “Principles and Practice of Cornea, Ophthalmic Gel of a New Treatment for Herpes sequencing identifies a mutation for a novel Simplex Keratitis. Current Eye Research. form of hereditary benign intraepithelial Sayegh, R, Afshari, N. Keratoprosthesis. 2 Volume Set”. Afshari NA, Gorovoy MS, Yoo SH, Kim T, May 2012; 37(7): 654-60. dyskeratosis. Association for Research in AAO Focal Points 2013. Atkinson MJ, Tally Carlson AN, Rosenwasser GO, Griffin NB, C: Robert N. Weinreb, M.D. edited, “Childhood Glaucoma”. Vision and Ophthalmology (ARVO). 2012. S, Heichel CW, Kozak I, Leich J, Levack A. McCuen BW, Toth CA, Price FW, Fenandez Meekins LC, Afshari NA. Ever-evolving A Qualitative Investigation of Visual Tasks D: Bobby S. Korn, M.D., Ph.D. and Don O. Kikkawa, M.D., edited, MM. Dislocation of donor graft to the technological advances in cataract surgery: Taylor DA, Copeland RA, Afshari, NA. Corneal with Which to Assess Distance-specific “Video Atlas of Oculofacial Plastic and Reconstructive Surgery”. posterior segment in descemet stripping can perfection be achieved? Curr Opin Biomechanics. Copeland RA, Afshari NA (eds.): Visual Function. Quality of Life Research automated endothelial keratoplasty. Ophthalmol 2012; 23:1-2. Copeland and Afshari’s The Principles Journal, March 2013. AmJ Ophthalmol 2012; 153:638-642. and Practice of Cornea. Two Volume Meekins LC, Rosado-Adames N, Maddala Cornea Textbook. Jaypee Brothers. 2012. Espandar L, Blanco T, Mathew R, Afshari N, Char Decroos F, Delmonte DW, Chow JH, R, Epstein DL, Rao V, Afshari NA. Corneal Bunnell B, Saban D. Human adipose- Stinnett SS, Kim T, Carlson AN, Afshari NA. endothelial cell migration and proliferation Wainright W, Farsiu S, Izatt JA, Afshari NA, derived stem cells promote wound healing Increased Rates of Descemet’s Stripping enhanced by Rho kinase (ROCK) inhibitors Kuo AN. Examining corneal endothelial of corneal epithelial cells in vitro. Association Automated Endothelial Keratoplasty (DSAEK) and statins. Association for Research in function after DSAEK. Association for for Research in Vision and Ophthalmology Graft Failure and Dislocation in Glaucomatous Vision and Ophthalmology (ARVO). 2012. Research in Vision and Ophthalmology (ARVO). 2013. Eyes with Aqueous Shunts. J Ophthalmic (ARVO). 2012. C D Vis Res 2012;7:203-13. Millender TW, Reller LB, Meekins LC, Espandar L, Afshari NA. Adult Corneal Stem Afshari NA. Streptococcal pharyngitis Wheeler J, Hauser MA, Afshari NA, Allingham Cells and Alternative Sources for Regenerative Chow J, Afshari NA. Posterior corneal leading to corneal ulceration. Ocul RR, Liu Y. The genetics of keratoconus: Therapy for the Cornea. Current Medical dystrophies. Copeland RA, Afshari NA Immunol Inflamm 2012; 20:143-4. a review. Reprod Syst Sex Disord 2012. Literature-Ophthalmology. Leading article. editor. Principles and Practice of Cornea. 2013 January, Volume 23, Issue 1. New Delhi: Jaypee Brothers, 2012. Rosado-Adames N, Goldhagen B, Meekins Afshari NA. A Family-based Investigation LC, Proia A, Epestin DL, Rao V, Afshari of the Role of TCF4 Trinucleotide Repeat Espandar L, Allingham RR, Afshari NA. Copeland RA, Afshari NA (Editors) Two NA. Expression profile of RhoA and Rho Expansion in Fuchs Endothelial Corneal Stromal Duplication of the Iris. Ophthalmic Volumes, The Principles and Practice of kinase in the human corneal epithelium and Dystrophy (FECD). Association for Research image. Accepted for publication. JAMA Cornea by Jaypee Brothers, September 2012. endothelium. Association for Research in in Vision and Ophthalmology (ARVO) 2013. Ophthalmology Journal. 2013. Vision and Ophthalmology (ARVO). 2012. Goldhagen BE, Hwang RY, Kuo AN, Afshari Afshari NA. Cross-linking Leads the Way Heichel CW, Yoon S. Herpes Simplex and NA. Changes in corneal biomechanics after Rosado-Adames N, Afshari NA. The changing in a Busy Year. Rev Ophthalmol 2013. Herpes Zoster In: Challenging Cases in penetrating keratoplasty in keratoconus. fate of the corneal endothelium in cataract Pediatric Ophthalmology. American Association for Research in Vision and surgery. Curr Opin Ophthalmol 2012; 23:3-6. Ciolino JB, Belin MW, Todani A, Al-Arfaj K, Academy of Pediatrics. Ophthalmology (ARVO). 2012. Rudnisky CJ; Boston Keratoprosthesis Type Rudnisky CJ, Belin MW, Todani A, Al-Arfaj 1 Study Group. Retention of the Boston Iyengar SK, Afshari NA, Igo R, Li YJ, Lass, Haw W. Redefining the Dry Eye Treatment K, Ament JD, Zerbe BJ, Ciolino JB; Boston keratoprosthesis type 1: multicenter study JL, Klintowrth G for the FECD Consortium. Strategy. Ophthalmology Update. Type 1 Keratoprosthesis Study Group. Risk results. Ophthalmology. 2013 Jun;120(6): Genome-wide association confirms TCF4 as 44 Supplement to Advanced Ocular Care. 45 a major locus for Fuchs Endothelial Corneal K, Afshari N, Schanzlin D. Comparison of Chang EE, Goldberg JL. Glaucoma 2.0: Glaucoma. ARVO 663/A329. 2012. using spectral domain optical coherence Liu S, Li ZW, Weinreb RN, Xu G, Lindsey JD, Mansouri K, Weinreb RN, Liu JHK. Effects Medeiros FA, Zangwill LM, Girkin CA, Liebmann Dystrophy and identifies novel loci. To be the Ocular Response Analyzer and the Belin- Neuroprotection, Neuroregeneration, tomography in glaucoma. Invest Ophthalmol Ye C, Yung WH, Pang CP, Lam DS, Leung of aging on 24-hour intraocular pressure JM, Weinreb RN. Combining structural and presented at the 63rd American Society of Ambrósio Ectasia Display for Detecting Eyes Neuroenhancement. Ophthalmology, Hertz J, Jin X, DeRosa B, Li J, Venugopalan Vis Sci. 2012;53:198-204. CK. Tracking retinal microgliosis in models measurements in sitting and supine body functional measurements to improve estimates Human Genetics Annual Meeting, Boston, at High Risk of Developing Ectasia After 119(5):979-86. PMC3343191. 2012. P, Valenzuela D, Patel R, Russano K, Muller K, of retinal ganglion cell damage. Investigative positions. Invest Ophthalmol Vis Sci. of rates of glaucomatous progression. Am J Massachusetts, October 2013. Refractive Surgery. Association for Research LeFebvre V, Dykxhoorn D, Goldberg JL. SoxC Lee D, Kim KY, Noh YH, Chai S, Lindsey JD, Ophthalmology and Visual Science. 2012;53:112-6. Ophthalmol. 2012;153:1197-205. in Vision and Ophthalmology (ARVO). 2013. Corredor RG, Pita-Thomas W, Trakhtenberg EF, family members regulate retinal ganglion cell Ellisman MH, Weinreb RN, Ju WK. Brimonidine 2012;53:6254-6262. Khor WB, Afshari NA. The role of presbyopia- Hu Y, Goldberg JL. Soluble adenylyl cyclase differentiation. World Stem Cell Summit, blocks glutamate excitotoxicity-induced Mansouri K, Medeiros FA, Tafreshi A, Medeiros FA, Zangwill LM, Mansouri K, Lisboa correcting intraocular lenses after laser in Afshari NA. An Overview of Keratoprosthesis. activity is necessary for retinal ganglion cell Palm Beach, FL #13531. 2012. oxidative stress and preserves mitochondrial Luo N, West C, Murga-Zamalloa C, Sun L, Weinreb RN. Continuous 24-Hour Monitoring R, Tafreshi A, Weinreb RN. Incorporating risk situ keratomileusis. Curr Opin Ophthalmol Agarwal A, Editor. Surgical Maneuvers on the survival and axon growth. J Neuroscience transcription factor a in ischemic retinal Anderson RM, Wells C, Weinreb RN, Travers JB, of Intraocular Pressure Patterns With factors to improve the assessment of rates of 2013; 24:35-40. Cornea. New Jersey: SLACK, In Press. 32(22):7734-44. PMC3372574. 2012. Hertz J, Jin X, Li J, Russano K, DeRosa B, injury. PLoS One. 2012;7(10):e47098. Khanna H, Sun Y. OCRL localizes to the primary a Contact Lens Sensor: Safety, Tolerability, glaucomatous progression. Invest Ophthalmol Valenzuela D, Dykxhoorn D, LeFebvre V, cilium and regulates ciliogenesis: a new role and Reproducibility in Patients With Glaucoma. Vis Sci. 2012;53:2199-207. Khor WB, Afshari NA. The more things change, Cruz-Martin A, Huberman AD. Visual Cognition: Goldberg JL. Control of retinal ganglion Lee EJ, Kim TW, Weinreb RN. Optic disc for cilia in Lowe syndrome. Hum Mol Genet. Arch Ophthalmol. 2012 Aug 13:1-6. PubMed the more they stay the same. Curr Opin GLAUCOMA rats compare shapes among the crowd. cell differentiation. SFN 425.02/A2. 2012. crescent and tilt - Reply. Ophthalmology. 2012;21:3333-44. PMID: 22892888. Medeiros FA, Zangwill LM, Anderson DR, Ophthalmol 2013; 24:1-2. Al-Shamekh S, Hertz J, Yuan C-C, DeRosa B, Current Biology, 22: R18-20. 2012. 2012;119:1942-3. Liebmann JM, Girkin CA, Harwerth RS, Fredette Uddin M, Corneo B, Temple S, Dykxhoorn D, Jaggi GP, Miller NR, Flammer J, Weinreb RN, Mansouri K, Weinreb RN. Continuous 24 hour Medeiros FA, Zangwill LM, Anderson DR, MJ, Weinreb RN. Estimating the rate of retinal Moussa K, Petrowski J, Afshari N. The Goldberg JL. Control of retinal ganglion cell Deokule S, Alencar L, Vizzeri G, Medeiros Remonda L, Killer HE. Optic nerve sheath Lee EJ, Kim TW, Weinreb RN. Improved intraocular pressure monitoring for glaucoma Liebmann JM, Girkin CA, Harwerth RS, ganglion cell loss in glaucoma. effect of the presence of preoperative differentiation. World Stem Cell Summit, F, Weinreb RN. Comparison of unenhanced diameter in normal-tension glaucoma reproducibility in measuring the laminar – time for a paradigm change. Swiss Med Wkly. Fredette MJ, Weinreb RN. Estimating the rate Am J Ophthalmol. 2012;154:814-24. silicone oil, absence of prior corneal Palm Beach, FL #12740. 2012. and enhanced imaging protocols for anterior patients. Br J Ophthalmol. 2012;96:53-6. thickness on enhanced depth imaging SD-OCT 2012;142:w13545. of retinal ganglion cell loss in glaucoma. Am J surgery, and postoperative scleral contact segment optical coherence tomography. images using maximum intensity projection. Ophthalmol. 2012 Nov;154(5):814-824. PubMed Mukkamala SK, Patel A, Dorairaj S, McGlynn R, lens use on Boston keratoprosthesis Apara A, Blackmore M, Wang Y, Bhattacharya Ophthalmic Surg Lasers Imaging. 2012; Johnstone AL, Reierson GW, Smith RP, Invest Ophthalmol Vis Sci. 2012;53:7576-82. Mansouri K, Weinreb RN. Meeting an unmet PMID: 22840484. Sidoti PA, Weinreb RN, Rusoff J, Rao S, Gentile outcomes. Association for Research in S, Goldberg JL. Protein-protein interactions 43:39-44. Goldberg JL, Lemmon VP, Bixby JL. A need in glaucoma: Continuous 24-hour RC. Ocular decompression retinopathy: Vision and Ophthalmology (ARVO). 2013. involved in the transcriptional control of chemical genetic approach identifies Leite MT, Zangwill LM, Weinreb RN, Rao HL, monitoring of intraocular pressure. Medeiros FA, Weinreb RN. Editorial: Is corneal A review. Surv Ophthalmol. 2012. intrinsic axon growth ability in retinal Duncan R, Sample P, Bowd C, Weinreb RN, piperazine antipsychotics as promoters of Alencar LM, Medeiros FA. Structure-function Expert Rev Med Devices. 2012;9:225-31. thickness an independent risk factor for Ong NH, Purcell TL, Roch-Levecq AC, Wang D, ganglion cells. SFN 531.17/B16. 2012. Zangwill LM. Arterial spin labeling fMRI CNS neurite growth on inhibitory substrates. relationships using the cirrus spectral domain glaucoma? Ophthalmology. 2012;119:435-6. Ng M, Sample PA, Pascual JP, Zangwill Isidro MA, Bottos KM, Heichel CW, Schanzlin measurements of decreased blood flow Mol Cell Neurosci. 50(2):125-135. 2012. optical coherence tomograph and standard Mansouri K, Medeiros FA, Weinreb RN. LM, Girkin CA, Liebmann JM, Weinreb RN, DJ. Epithelial Healing and Visual Outcomes Bajenaru ML, Rachelle A, Santos C, Obeso in primary visual coretex correlates with automated perimetry. J Glaucoma. Intraocular pressure changes during sexual Medeiros FA, Weinreb RN, Boer E, Rosen PN. Racette L. Comparison of visual field severity of Patients Using Omega-3 Oral Nutritional BA, Trakhtenberg E, Ivanov D, Ponmattam J, decreased visual function in human Kador KE, and Goldberg JL. Scaffolds and Stem 2012;21:49-54. activity. Acta Ophthalmol. 2012. Driving simulation as a performance-based test classification systems for glaucoma. Supplements Before and After Photorefractive Gutierrez S, Hernandez E, Fini ME, Goldberg glaucoma. Vis Res. 2012;60:51-60. Cells: Delivery of Cell Transplants for Retinal of visual impairment in glaucoma. J Glaucoma. J Glaucoma. 2012;21:551-61. Keratectomy: A Pilot Study. Cornea. 2013 JL. β1 Integrin-Focal Adhesion Kinase (FAK) Degenerations. Exp. Rev. of Ophthalmology, Leung CKS, Yu M, Weinreb RN, Ye C, Liu S, Mansouri K, Medeiros FA, Tafreshi A, 2012;21:221-27. June; 32(6):761-5. Signaling Modulates Retinal Ganglion Cells El-Danaf RN, Huberman AD. 7(5):459-470. 2012. Lai G, Lam DSC. Retinal nerve fiber layer Weinreb RN. Continuous 24-hour monitoring Parekh A, Dorairaj S, Weinreb RN. Survival. ARVO 3482/D786. 2012. Wiring visual circuits, one eye at a time. imaging with spectral-domain optical of intraocular pressure patterns with a Medeiros FA, Zangwill LM, Bowd C, Mansouri Anterior chamber blood reflux during cataract Oboite M, Stinnett S, Carlson, A, Afshari NA. Nature Neuroscience 15: 1-2. 2012. Kim TW, Kim M, Weinreb RN, Woo SJ, coherence tomography – a prospective contact lens sensor: Safety, tolerability, K, Weinreb RN. The structure and function extraction in an eye with previous trabectome Insurance, race, gender and how they relate Balasubramanian M, Kriegman DJ, Bowd C, Park KH, Hwang JM. Optic disc change analysis on age-related loss. Ophthalmology. and reproducibility in patients with glaucoma. relationship in glaucoma: implications for surgery. Am J Ophthalmol. 2012. to visual acuity at the time of cataract surgery. Holst M, Weinreb RN, Sample PA, Zangwill LM. Goldbaum MH, Lee I, Jang G, Sample PA, with incipient myopia of childhood. 2012;119:731-7. Arch Ophthalmol. 2012;130:1534-40. detection of progression and measurement Association for Research in Vision Localized glaucomatous change detection Balasubramanian M, Weinreb RN, Liebmann Ophthalmology. 2012;119:21-6. of rates of change. Invest Ophthalmol Vis Sci. Pita-Thomas DW, Steketee MB, Kador K, and Ophthalmology (ARVO). 2013. within the proper orthogonal decomposition JM, Girkin CA, Anderson DR, Zangwill LM, Kim TW, Kim M, Weinreb RN. Myopia and Leung CKS, Yu M, Weinreb RN, Mak H, Mansouri K, Liu JHK, Weinreb RN, Tafreshi A, 2012 Oct 5;53(11):6939-46. PubMed PMID: Hampton BM, Thakor KA, Moysidis S, framework. Investigative Ophthalmology and Fredette M-J, Jung T-P, Medeiros FA, Bowd glaucoma – author reply. Ophthalmology. Lai G, Cong Y, Lam DSC. Retinal nerve fiber Medeiros FA. Analysis of continuous 24-hour 22893677. Weinstein JE, Jin X, Goldberg JL. Rosado-Adames N, Afshari NA. Corneal Visual Science, 53(7), 3615-3628. 2012. C. Progression of Patterns (POP): A machine 2012;119:1501. layer imaging with spectral-domain optical intraocular pressure patterns in glaucoma. Functionalized nanoparticles to endothelium. Yanoff M, Duker J, Editors. classifier algorithm to identify glaucoma coherence tomography: Interpretating the Invest Ophthalmol Vis Sci. 2012;53:8050-6. Medeiros FA, Lisboa R, Weinreb RN, Girkin enhance regenerative axon growth. Ophthalmology. London: Elsevier, 2013. Blackmore MG, Wang Z, Lerch J, Motti D, progression in visual fields. Investigative Lee EJ, Kim TW, Weinreb RN, Suh MH, Kim H. RNFL maps in healthy myopic eyes. Invest CA, Liebmann JM, Zangwill LM. A combined SFN 346.18/J17. 2012. Zhang YP, Shields C, Lee JK, Goldberg JL, Ophthalmology and Visual Science, 53(10), Lamina cribrosa thickness is not correlated Ophthalmol Vis Sci. 2012;53:7194-200. Mansouri K, Liu JH, Tafreshi A, Medeiros index of structure and function for staging Soler VJ, Tran-Viet KN, Galiacy SD, Lemmon VP, Bixby JL. KLF7 engineered for 6557-6567. 2012. with central corneal thickness or axial length FA, Weinreb RN. Positional independence glaucomatous damage. Arch Ophthalmol. 2012 Pita-Thomas DW, Steketee M, Hampton B, Limviphuvadh V, Klemm TP, St Germain E, transcriptional activation promotes axon in healthy eyes: Central corneal thickness, Leung CKS, Yu M, Weinreb RN, Lai G, Xu G, of optic nerve head and retinal nerve fiber Sep;130(9):1107-16. PubMed PMID: 22826832. Goldberg JL. Synaptotagmin vesicle trafficking Fournié PR, Guillaud C, Maurer-Stroh S, regeneration in the adult corticospinal tract. Goldberg JL. Physiology of the Optic Nerve. axial length, and lamina cribrosa thickness. Lam DSC. Retinal nerve fiber layer imaging layer thickness measurements with spectral- to the nerve injury site: Implications for injury Hawthorne F, Suarez C, Kantelip B, Afshari PNAS 109(19):7517-22. PMC3358880. 2012. In, Duane’s Ophthalmology, Lippincott Graefes Arch Clin Ex Ophthalmol. 2012. with spectral-domain optical coherence domain optical coherence tomography. Am J Medeiros FA, Zangwill LM, Weinreb RN. sealing and new growth cone formation. NA, Creveaux I, Luo X, Meng W, Calvas P, Williams & Wilkins; William Tasman and tomography: patterns of retinal nerve Ophthalmol. 2012 Oct;154(4):712-721. Improved prediction of rates of visual field loss Cold Spring Harbor Labs Axon Guidance Cassagne M, Arné JL, Rozen SG, Malecaze Bowd C, Lee I, Goldbaum MH, Edward Jaeger, Eds. 2012. Lee EJ, Kim TW, Weinreb RN. Reversal fiber layer progression. Ophthalmology. PubMed PMID: 22818801. in glaucoma using empirical Bayes estimates of Synapse Formation and Regeneration. F, Young TL. Whole exome sequencing Balasubramanian M, Medeiros FA, Zangwill of lamina cribrosa displacement and 2012;119:1858-66. slopes of change. J Glaucoma. 2012;21:147-54. CSHL Meeting; 132. 2012. identifies a mutation for a novel form LM, Girkin CA, Liebmann JM, Weinreb RN. Goldberg JL. Role of Electrical Activity thickness after trabeculectomy in glaucoma. Mansouri K, Leite MT, Weinreb RN, Tafreshi of corneal intraepithelial dyskeratosis. Predicting glaucomatous progression in in Neural Repair. Neuroscience Letters, Ophthalmology. 2012;119:1359-66. Lisboa R, Leite MT, Zangwill LM, Tafreshi A, Zangwill LM, Medeiros FA. Association Medeiros FA, Weinreb RN, Moore G, Liebmann Pita-Thomas DW, Steketee M, Goldberg JL, J Med Genet 2013;504:246-54. glaucoma suspect eyes using relevance vector 519(2):134-7. PMC3360133. 2012. A, Weinreb RN, Medeiros FA. Diagnosing between corneal and biomechanical JM, Girkin CA, Zangwill LM. Integrating event- Kador K. Functionalized Nanoparticles To machine classifiers for combined structural Lee EJ, Kim TW, Weinreb RN, Suh MH, preperimetric glaucoma with spectral properties and glaucoma severity. and trend-based analyses to improve detection Enhance Regenerative Axon Growth. Vola Ravina M, Lisboa R, Schimchak P, Kishi and functional measurements. Invest Griffith JF, Goldberg JL. The Frequency of Kang MJ, Park KH, Kim SH, Kim DM. Three- domain optical coherence tomography. Am J Ophthalmol. 2012;153:419-27. of glaucomatous visual field progression. ARVO 303/A544. 2012. 46 Ophthalmol Vis Sci. 53:2382-9. 2012. Optical Coherence Tomography Testing in Dimensional evaluation of the lamina cribrosa Ophthalmology. 2012;119:2261-9. Ophthalmology. 2012;119:458-67. 47 Rodrigues EB, Medeiros F, Mennel S, effect of Set-β on axon growth. GLAUGEN consortia. Invest Ophthalmol Vis KF, Friedman DS, Gaasterland D, Gaasterland Chindasub P, Lindsey JD, Duong-Polk K, 34(17):4242–4250. 2013. Lindsey JD, Grob SR, Scadeng M, Duong- Luo N, Kumar A, Conwell M, Weinreb Penha FM. Optical coherence tomography SFN 531.01/A70.2. 2012. Sci. 2012;53:4468-74. T, Laurie C, Lee RK, Lichter PR, Loomis S, Leung CK, Weinreb RN. Inhibition of histone Kador K, Salero-Coca E, Russano K, Lau LW, Polk K, Weinreb RN. Ocular integrity following RN, Nussbaum R, Anderson R, Sun Y. in ophthalmology. J Ophthalmol. Liu Y, Medeiros FA, McCarty C, Mirel D, Moroi deacetylases 1 and 3 protects injured retinal Goldberg JL. Tissue Engineered Model of manganese labeling of the visual system Compensatory role of inositol 5-phosphatase 2012;2012:134569. doi: 10.1155/2012/134569. Trakhtenberg EF, Goldberg JL, eds. Valenzuela D, Hertz J, Qu B, Patel R, Goldberg SE, Musch DC, Realini A, Rozsa FW, Schuman ganglion cells. Investigative Ophthalmology the Outer Neural Retina and Retinal Pigment for MRI. Magnetic Resonance Imaging. INPP5B to OCRL in primary cilia formation in Epub 2012 Apr 24. PubMed PMID: 22619700; Axon Growth and Regeneration, Part II. JL. Survival and Integration of Developing JS, Scott K, Singh K, Stein JD, Trager EH, and Visual Science. 2013;54:96-102. Epithelium. ARVO, 1302/B10. 2013. 2013;31:865-874. oculocerebrorenal syndrome of Lowe. PLoS PubMed Central PMCID: PMC3348683. International Review of Neurobiology and Progenitor-Derived Retinal Ganglion Cells Vanveldhuisen P, Vollrath D, Wollstein G, ONE. 2013;8:e66727. Vol 106. Elsevier Press (London). 2012. Following Transplantation. World Stem Cell Yoneyama S, Zhang K, Weinreb RN, Ernst Dai Y, Lindsey JD, Duong-Polk KX, Kim MJ, Kim TW, Weinreb RN, Lee EJ. Lisboa R, Paranhos A Jr, Weinreb RN, Santos AC, Corredor RG, Obeso Summit, Palm Beach, FL #13530. 2012. J, Kellis M, Masuda T, Zack D, Richards JE, Chindasub P, Leung CK, Weinreb RN. Differentiation of parapapillary atrophy Zangwill LM, Leite MT, Medeiros FA. Mansouri K, Weinreb RN, Medeiros FA. BA, Trakhtenberg EF, Ponmattam J, Trakhtenberg EF, Goldberg JL, eds. Pericak-Vance M, Pasquale LR, Haines JL. Brimonidine protects against loss of Thy-1 using spectral domain optical coherence Comparison of Different Spectral Domain Is 24-hour Intraocular Pressure Monitoring Dvoriantchikova G, Ivanov D, Shestopalov Axon Growth and Regeneration, Part I. Wang Y, Brown D, Watson B, Duan Y, Goldberg Common variants at 9p21 and 8q22 are promoter activation following optic nerve tomography. Ophthalmology. 2013. OCT Scanning Protocols for Diagnosing Necessary in Glaucoma? Semin VI, Goldberg JL, Fini ME, Bajenaru ML. β1 International Review of Neurobiology JL. Novel Rodent Model of Posterior Ischemic associated with increased susceptibility crush. BMC Ophthalmology 2013;13:26. Preperimetric Glaucoma. Invest Ophthalmol Ophthalmol. 2013 May;28(3):157-64. integrin-focal adhesion kinase (FAK) signaling Vol 105. Elsevier Press (London). 2012. Optic Neuropathy. ARVO 2977/D766. 2012. to optic nerve degeneration in glaucoma. Kunzevitzky NJ, Alvarez-Delfin K, Vis Sci. 2013 May 13;54(5):3417-25. PubMed PMID: 23697618. modulates retinal ganglion cell (RGC) survival. PLoS Genet. 2012;8(4):e1002654. Epub Grippo TM, Liu JHK, Zebardast N, Arnold TB, Merkhofer RM, Weisman AD, Goldberg PubMed PMID: 23532529. PLoS One, 7(10):e48332. PMC3485184. 2012. Trakhtenberg EF, Goldberg JL. The Role Wang N, Xie X, Yang D, Xian J, Li Y, Ren R, 2012 Apr 26. PubMed PMID: 22570617; Moore GH, Weinreb RN. Twenty-four-hour JL. The transparency transcriptome: gene Mansouri K, Tung JD, Medeiros FA, Tafreshi A, of Serotonin in Axon and Dendrite Growth. Wang H, Zhang S, Kang Z, Peng X, Sang PubMed Central PMCID: PMC3343074. pattern of intraocular pressure in untreated expression profile of human corneal Lisboa R, Chun YS, Zangwill LM, Weinreb RN, Dorairaj S, Zangwill L, He F, Jain S, Weinreb Seo JH, Kim T-W, Weinreb RN, Park KH, Kim In, Axon Growth and Regeneration, Part II. J, Zhang Z, Jonas JB, Weinreb RN. Orbital patients with ocular hypertension. Invest endothelial cells. ARVO, 1698/D333. 2013. Rosen PN, Liebmann JM, Girkin CA, Medeiros RN. Semiautomated quantification of β-zone SH, Kim DM. Detection of localized retinal International Review of Neurobiology Vol cerebrospinal fluid space in glaucoma: Beijing Zhang K, Zhang L, Weinreb RN. Ophthalmic Ophthalmol Vis Sci 2013;54:512-517. FA. Association between rates of binocular parapapillary atrophy using blue light fundus nerve fiber layer defects with posterior pole 106 pp105-126. Elsevier Press (London); E.F. Intracranial and Intraocular Pressure (iCOP) drug discovery: novel targets and mechanisms Kushnareva YE, Gerencser AA, Bossy B, Ju visual field loss and vision-related quality autofluorescence. Acta Ophthalmol. 2013 Mar asymmetry analysis of spectral-domain optical Trakhtenberg and J.L. Goldberg, eds. 2012. Study. Ophthalmology. 2012;119:2065-73. for retinal disease and glaucoma. Nat Rev Hertz J, Goldberg JL. Stem Cells and WK, White AD, Waggoner J, Ellisman MH, of life in patients with glaucoma. JAMA 18. doi: 10.1111/aos.12057. [Epub ahead of print] coherence tomography. Invest Ophthalmol Drug Discov. 2012;11:541-59. Glaucoma. In, Stem Cell Biology and Perkins G, Bossy-Wetzel E. Loss of OPA1 Ophthalmol. 2013 Apr;131(4):486-94. PubMed PMID: 23506312. Vis Sci. 2012;53:4347-53. Trakhtenberg EF, Goldberg JL. Epigenetic Weinreb RN, Coleman AL. Interpreting clinical Regenerative Medicine in Ophthalmology, disturbs cellular calcium homeostasis and PubMed PMID: 23450425. Regulation of Axon and Dendrite Growth. studies on glaucoma neuroprotection. In: Akinwuntan AE, Gantt D, Gibson G, Kimmons pp 75-98. Humana Press (New York); sensitizes for excitotoxicity. Cell Death Differ. Mansouri K, Medeiros FA, Tafreshi A, Seo JH, Kim T-W, Weinreb RN, Kim YA, Kim Frontiers in Molecular Neuroscience, Shaaraway T, Sherwood M, Hitchings R, K, Ross V, Rosen PN, and Wachtel J. United S.H. Tsang, ed. 2013. 2013;20(2):353-65. Lisboa R, Weinreb RN, Medeiros FA. Weinreb RN. Validity of the results of MJ. Relationship of intraocular pressure and 5:24 epub Mar 1. PMC3290832. 2012. Crowston J. Glaucoma Second Edition. States Version of the Stroke Driver Screening Combining structure and function to evaluate a contact lens sensor?-Reply. JAMA frequency of spontaneous retinal venous London: Saunders Elsevier. 2012. Assessment: A Pilot Study. Top Stroke Rehabil Hertz J, Robinson R, Valenzuela DA, Lavik EB, Lee EJ, Kim TW, Weinreb RN, Kim H. glaucomatous progression: implications for the Ophthalmol. 2013 May 1;131(5):696-8. pulsation in primary open-angle glaucoma. Trakhtenberg EF, Wang Y, Fernandez SG, 2013;20(1):87–92. Goldberg JL. A tunable synthetic hydrogel Reversal of lamina cribrosa displacement design of clinical trials. Curr Opin Pharmacol. doi: 10.1001/jamaophthalmol.2013.208. Ophthalmology. 2012;119:2254-60. Lapins A, Schechter J, Yang S, Liu X, Goldberg Weinstein JE, Steketee MB, Goldberg JL. system for culture of retinal ganglion cells after intraocular pressure reduction in 2013 Feb;13(1):115-22. PubMed PMID: 23219155. PubMed PMID: 23699850. JL. Subcellular localization-dependent effect Developmental Distribution of Mitochondria Alvarez-Delfin K, Kunzevitzky NJ, Weisman AD, and amacrine cells. Acta Biomaterialia, open-angle glaucoma. Ophthalmology. Steketee MB, Goldberg JL. Signaling of Set-β on axon growth and regeneration. in Retinal Ganglion Cell Axons. Merkhofer RM, Goldberg JL. A cell therapy In press. 2013. 2013;120553:59. Lisboa R, Zangwill LM, Weinreb RN, Mansouri K, Goedkoop R, Weinreb RN. Endosomes and Growth Cone Motility in CSHL Meeting; 175. 2012. ARVO 3968/D832. 2012. approach to address corneal endothelial Medeiros FA. Continuous Likelihood Ratios A minimally invasive device for the monitoring Axon Regeneration. In, Axon Growth and dysfunction. ARVO 1648/D283. 2013. Hertz J, Qu B, Hu Y, Patel R, Valenzuela D, Lee EJ, Kim T-W, Weinreb RN. for Glaucoma Diagnosis Using Spectral of 24-hour intraocular pressure patterns. Regeneration, Part II. International Review of Trakhtenberg EF, Wang Y, Fernandez S, Wester ST, Goldberg JL. Stem Cells In Goldberg JL. Survival and Integration of Variation of lamina cribrosa depth Domain Optical Coherence Tomography. US Ophthalmic Review. 2013;6:10-4. Neurobiology Vol 106 pp35-74. Elsevier Press Lapins A, Panara R, Shechter J, Rottmann Ophthalmology. Stem Cell Transplantation, Beier K, El-Danaf RN, Huberman AD, Demb J, Developing and Progenitor-Derived Retinal following trabeculectomy. Invest Amer J Ophthalmology 2013 (in press) (London); E.F. Trakhtenberg and J.L. R, Farmer J, Yang S, Goldberg JL. Set-β InTech Press; T. Demirer, Ed. 2012. Cepko CL (2013) Trans-synaptic tracing with Ganglion Cells Following Transplantation. Ophthalmol Vis Sci. 2013. Medeiros FA, Lisboa R, Zangwill LM, Liebmann Goldberg, eds. 2012. Subcellular Localization-dependent Regulation vesicular stomatitis virus reveals novel retinal Cell Transplantation, In press. 2013. Lisboa R, Chun YS, Zangwill, LM, JM, Girkin C, Weinreb RN. Retinal ganglion Of Retinal Ganglion Cell Neurite Growth. Wiggs JL, Hauser MA, Abdrabou W, Allingham circuitry. Journal of Neuroscience, 33: 35-51. Leung CK, Cong Y, Weinreb RN. An ultra-high Weinreb RN, Rosen PN, Liebmann, JM, cell count estimates associated with early Steketee MB, Moysidis SN, Weinstein JE, ARVO 290/A531. 2012. RR, Budenz DL, Delbono E, Friedman DS, Jeoung JW, Kim TW, Weinreb RN, Kim SH, speed Scheimpflug Camera for evaluation of Girkin CA, and Medeiros FA. Relationship development of visual field defects in Kreymerman A, Silva J, Iqbal S, Goldberg JL. Kang JH, Gaasterland D, Gaasterland T, Bhattacharya SK, Lee RK, Grus FH; Seventh Park KH, Kim DM. Diagnostic ability of spectral- corneal deformation responses and its impact Between Rates of Binocular Visual Field glaucoma. Ophthalmology. 2013;120:736-44. Mitochondrial dynamics regulate growth cone Tung JD, Tafreshi A, Weinreb RN, Slight JR, Lee RK, Lichter PR, Loomis S, Liu Y, McCarty ARVO/Pfizer Ophthamalics Research Institute domain versus time-domain optical coherence on intraocular pressure measurement. Invest Loss and Vision-Related Quality of Life in motility, guidance, and neurite growth rate in Medeiros FA, Liu JHK. Twenty-four-hour C, Medeiros FA, Moroi SE, Olson LM, Realini Conference Working Group. Molecular tomography in preperimetric glaucoma. Ophthalmol Vis Sci. 2013. Glaucoma. Arch Ophthal, 2013 (in press). Medeiros FA, Lisboa R, Bowd C, Weinreb perinatal retinal ganglion cells in vitro. IOVS, effects of bimatoprost 0.01% monotherapy A, Richards JE, Rozsa FW, Schuman JS, Singh biomarkers in glaucoma. Invest Ophthalmol J Glaucoma. 2013. RN, Liebmann JM, Girkin CA, Zangwill LM. 53(11):7402-11. 2012. on intraocular pressure and ocular perfusion K, Stein JD, Vollrath D, Weinreb RN, Wollstein Vis Sci. 2013;54(1):121-31. Leung CSK, Ye C, Weinreb RN, Marco Y, Lai Lisboa R, Chun YS, Zangwill LM, Weinreb RN, Evaluation of Progressive Neuroretinal pressure. BMJ Open 2012;2:e001106. G, Yaspan BL, Yoneyama S, Zack D, Zhang K, Kamei G, Kobayashi T, Ohkawa S, G, Lam DS. Impact of age-related change of Rosen PN, Liebmann JM, Girkin CA, Medeiros Rim Loss as a Surrogate Endpoint for Steketee M, Weinstein JE, Kreymerman A, Pericak-Vance M, Pasquale LR, Haines JL. Chao DL, Salero E, Wang Y, Volmar Kongcharoensombat W, Adachi N, Takazawa retinal nerve fiber layer and macular thickness FA. Association between rate of binocula Development of Visual Field Loss in Goldberg JL. Activity-dependent expression Ulmer M, Li J, Yaspan BL, Ozel AB, Richard JE, The NEIGHBOR Consortium Primary Open- CH, Goldberg JL. Elucidating molecular K, Shibuya H, Deie M, Hattori K, Goldberg JL, on evaluations of glaucoma progression. visual field loss and vision-related quality Glaucoma. Ophthalmology 2013 (in press) of nuclear encoded mitochondrial proteins Moroi SE, Hawthorne F, Budenz DL, Friedman Angle Glaucoma Genome-wide Association mechanisms of blood retina barrier Ochi M. Articular cartilage repair with magnetic Ophthalmology. 2013. of life in patients with glaucoma. in retinal ganglion cell axons in vivo. DF, Gaasterland D, Haines J, Kang JH, Lee R, Study: Rationale, Study Design, and Clinical permeability. ARVO, 5612/B135. 2013. mesenchymal stem cells. Am J Sports Med. JAMA Opht. 2013;131:486-94. Medeiros FA. Effect of intraocular pressure on SFN 312.08. 2012. Lichter P, Liu Y, Pasquale LR, Pericak-Vance Variables. J Glaucoma. 2012 Jul 23. 41(6):1255-64. 2013. Lindsey JD, Duong-Polk KX, Dai Y, Nguyen DH, the bayesian estimation of rates of visual field M, Realini A, Schuman JS, Singh K, Vollrath PubMed PMID: 22828004. Chen SY, Mahabole MA, Horesh EL, Leung CK, Weinreb RN. Protection by an oral Liu JHK, Lynch JE, Rosales-Velderrain A, progression in glaucoma. Invest Trakhtenberg EC, Wang Y, Fernandez SG, D, Weinreb R, Wollstein G, Zack D, Zhang K, Wester ST, Goldberg JL, Tseng SC. Kador KE, Montero RB, Venugopalan P, Hertz disubstituted hydroxylamine derivative against Chang DG, Weinreb RN, Hargens AR. Ophthalmol Vis Sci. 2013 Jun 9;54(6). Lapins A, Schechter J, Gupta K, Farmer J, Young T, Allingham RR, Wiggs JL, Ashley- Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Isolation and Characterization of Stem J, Zindell AN, Valenzuela DA, Uddin MS, Lavik loss of retinal ganglion cell differentiation Anterior-posterior transcranial ultrasound PubMed PMID: 23785101. Yang S, Liu X, Mlacker GM, Goldberg JL. Koch A, Hauser MA. Genome-wide analysis Allingham RR, Olson LM, Abdrabou W, Fan Cells from Human Orbital Adipose EB, Muller KJ, Andreopoulos FM, Goldberg JL. following optic nerve crush. PLoS One. to measure cranial oscillations. Aviat Subcellular localization-dependent of central corneal thickness in primary-open BJ, Wang DY, Brodeur W, Budenz DL, Caprioli Tissues. ARVO 735/D0394. 2013. Tissue Engineering the Retinal Ganglion Cell 2013;8:e65966. Space Environ Med 2013;84:995-1000. Medeiros FA, Meira-Freitas D, Lisboa R, 48 angle glaucoma cases in the NEIGHBOR and J, Crenshaw A, Crooks K, Delbono E, Doheny Nerve Fiber Layer. Biomaterials, Kuang TM, Zangwill LM, Weinreb RN. 49 Corneal Hysteresis as a Risk Factor for Pasquale L, Loomis S, Weinreb R, Kang 131(2):194-204. 2013. Nuyen B, Whipple KM, Korn BS, Kikkawa DO. Unpicking the UPR. Invest Ophthal Vis Baber L, Robbins SL, Adenoviral Conjunctivitis Roa AM, Robbins SL, Pseudoesotropia In: 2013 Jan;131(1):189-95. Glaucoma Progression: A Prospective J, Yaspan B, Bailey JC, Gaasterland D, Conjunctival-orbital fisutal from extensive Sci. 53: 7167. PMID: 23065632. 2012. In: Challenging Cases in Pediatric Ophthal. Challenging Cases in Pediatric Ophthal. Longitudinal Study. Ophthalmology. 2013 May Gaasterland T, Lee R, Scott B, Lichter P, Wang Y, Apara A, Blackmore M, Brown facial trauma. Ophthal Plast Reconstr Surg. American Academy of Pediatrics. Granet D, American Academy of Pediatrics. Granet D, Oh SR, Tung JD, Priel A, Levi L, Granet DB, 1. doi:pii: S0161-6420(13)00047-X. 10.1016/j. Budenz D, Liu Y, Realini T, Friedman D, DP, LeBlanc ME, Trillo AE, Goldberg JL. 2013, 29:e85. Chiang WC, Messah C, Lin JH. IRE1 directs Baber L, Robbins SL eds. Elk Grove Village, Baber L, Robbins SL eds. Elk Grove Village, Korn BS, Kikkawa DO. Reduction of Orbital ophtha.2013.01.032. PubMed PMID: 23642371. McCarty C, Moroi S, Olson L, Schuman J, Regulation of Krüppel-like Transcription proteasomal and lysosomal degradation of IL. 2012. 9-13. IL. 2012. 375-378. Inflammation Following Decompression for Singh K, Vollrath D, Wollstein G, Zack D, Factor (KLF’s) Family Members Promotes Oh SR, Tung JD, Priel A, Levi L, Granet DB, misfolded rhodopsin. Mol Biol Cell. 23(5): Thyroid-Related Orbitopathy. BioMed Meira-Freitas D, Lisboa R, Medeiros FA. Brilliant M, Sit A, Christen W, Fingert J, Potent Axon Regeneration in the Adult Korn BS, Kikkawa DO. Reduction of Orbital 758-770. e11-08-0663. PMID: 22219383. 2012. Barnhardt C, Cotter SA, Mitchell GL, Scheiman Roa AM, Granet DB, Robbins SL, Intermittent Research International. Volume 2013. Advances in the Structural Evaluation Kraft P, Zhang K, Allingham R, Pericak-Vance Rat Optic Nerve. ARVO 4693/B262. 2013. Inflammation following Decompression for M, Kulp MT; CITT Study Group. Symptoms Exotropia In: Challenging Cases in Pediatric of Glaucoma with Optical Coherence MA, Richards J, Hauser M, Haines JL, Wiggs J. Thyroid-Related Orbitopathy. Biomed Res Gorbatyuk MS, Shabashvili A, Chen W, in Children with Convergence Insufficiency; Ophthal. American Academy of Pediatrics. Rao AA, Naheedy JH, Chen JYY, Robbins SL Tomography. Curr Ophthalmol Rep Estrogen pathway polymorphisms in relation Weinstein JE, Weiss MJ, Goldberg JL. Int. 2013:794984. Meyers C, Sullivan LF, Lin JH, Lewin AS, before and after treatment. Optom Vis Sci Granet D, Baber L, Robbins SL eds. and Ramkumar HL. A Clinical Update and (2013) 1:98–105. to primary open angle glaucoma: An analysis An animal model for epithelial downgrowth. Muzyczka N, Gorbatyuk OS. Glucose regulated 2012 Oct;89(10):1512-20. Elk Grove Village, IL. 2012. 391-396. Radiologic Review of Pediatric Orbital and accounting for gender from the United States. ARVO 2575/D375. 2013. Oh SR, Korn BS, Kikkawa DO. Orbitomalar protein 78 (GRP78/BiP) diminishes a-synuclein Ocular Tumors. Journal of Oncology. Meira-Freitas D, Lisboa R, Tatham A, Mol Vis. 2013. Suspension With Combined Single Drill Hole neurotoxicity in a rat model of Parkinson Du H, Grob SR, Zhao L, Lee J, El-Sahn M, Roa AM, Robbins SL, Third Cranial Nerve Palsy Epub 2013 Mar 12. Zangwill LM, Weinreb RN, Girkin CA, Weiss MJ, Weinstein JE, Goldberg JL. Canthoplasty. Ophthal Plast Reconstr Surg. Disease. Mol Therapy. PMID: 22434142. 2012. Hugh G, Luo J, Schaf K, Duan Y, Quach J, In: Challenging Cases in Pediatric Ophthal. Liebmann JM, Medeiros FA. Predicting Piscopo DM, El-Danaf RN, Huberman AD, Animal model for epithelial downgrowth. 2013. Wei X, Shaw P, Granet D, Zhang K. Myotonia American Academy of Pediatrics. Granet D, progression in glaucoma suspects with Niell CM* (2013) Diverse visual features ASCRS, San Francisco. 2013. Gorbatyuk MS, Gorbatyuk OS, LaVail MM, Congenita with strabismus in a large family Baber L, Robbins SL eds. Elk Grove Village, RETINA longitudinal estimates of retinal ganglion cell encoded in mouse lateral geniculate nucleus. Priel A, Oh SR, Whipple KM, Korn BS, Kikkawa Lin JH, Hauswirth WW, Lewin AS. Functional with a mutation in the SCN4A gene. IL. 2012. 397-402. Asif Naeem M, Chavali VRM, Ali S, Iqbal M, counts. Invest Ophthalmol Vis Sci. 2013 Jun Journal of Neuroscience, 33: 4642-4656. Zangwill LM, Jain S, Dirkes K, He F, Medeiros DO. Reply re: “Use of Antimetabolites in the rescue of P23H rhodopsin photoreceptors by Eye (London) 2012 Jun 1: 1038. Riazuddin S, Khan SN, Husnain T, Ayyagari 19;54(6):4174-83. PubMed PMID: 23661375 (*co-senior authors) FA, Trick GL, Brandt JD, Cioffi GA, Coleman Reconstruction of Severe Anophthalmic Socket gene delivery. Adv Exp Med Biol. 723: 191-197. Roa AM, Robbins SL, Congenital Fourth Cranial R, Sieving PA, Amer Riazuddin S, Hejtmancik AL, Liebmann JM, Piltz-Seymour JR, Gordon Contraction”. Ophthal Plast Reconstr Surg. PMID: 22183333. 2012. Gore C, Robbins SL. Capillary Hemangioma: Nerve Palsy In: Challenging Cases in Pediatric JF, Riazuddin SA. GNATI associated with Moore, G.H., Bowd, C., Medeiros, F.A., Sample, Pita-Thomas DW, Goldberg JL. MO, Kass MA, Weinreb RN; Confocal Scanning 2013, 29:329. Eye Wiki informational Page by the American Ophthal. American Academy of Pediatrics. autosomal recessive congential stational P.A., Liebmann, J.M., Girkin, C.A., Leite, M.T., Nanotechnology and Glaucoma: Laser Ophthalmoscopy Ancillary Study to the Kroeger H, Messah C, Ahern K, Gee J, Joseph Academy of Ophthalmology [internet]. Granet D, Baber L, Robbins SL eds. night blindness. Invest Ophthalmol Vis Sci, Weinreb, R.N., & Zangwill, L.M. (2013). African Little Particles for a Big Disease. Current Ocular Hypertension Treatment Study. The rate Whipple KM, Lim LH, Korn BS, Kikkawa DO. V, Matthes MT, Yasumura D, Gorbatyuk MS, Dec 2012. http://eyewiki.aao.org/Capillary_ Elk Grove Village, IL. 2012. 403-408. 53:1353-61. 2012. Descent and Glaucoma Evaluation Study: Opinion in Ophthalmology, 24(2):130-135. 2013. of structural change: the confocal scanning Blepharoplasty Complications: Preventation Chiang WC, LaVail MM, Lin JH. Induction of Hemangioma. Asymmetry of structural measures in normal laser ophthalmoscopy ancillary study to the and Management. Clin Plast Surg. 2013; endoplasmic reticulum stress genes, BiP and Robbins SL, Infantile Esotropia In: Challenging Barteselli G, Chhablani J, El-Emam S, Wang participants. Journal of Glaucoma, 22(2), 65-72. Qu B, Hertz J, Patel RD, Wang Y, Goldberg ocular hypertension treatment study. 40:213-24. Chop, in genetic and environmental models Granet D, Robbins SL, Baber L, eds. Academy Cases in Pediatric Ophthalmology. American H, Chuang J, Kozak I, Cheng L, Bartsch DU, JL. Retinal Ganglion Cell Transplantation after Am J Ophthalmol. 2013 Jun;155(6):971-82. of retinal degeneration. Invest Ophthal Vis Sci. of Pediatrics. Challenging Cases in Pediatric Academy of Pediatrics. Granet D, Baber L, Freeman WR. Choroidal volume variations with Morkin MI, Trakhtenberg EF, Wang Y, Optic Nerve Injury. ARVO 2243/A0112. 2013. doi: 10.1016/j.ajo.2013.01.020. Epub 2013 Haidar YM, Korn BS, Rose MA. Complete 53(12): 7590-7599. PMID: 23074209. 2012. Ophthalmology. Elk Grove Village, IL: eds. Elk Grove Village, IL. 2012. 379-384. age, axial length, and sex in healthy subjects: Fernandez S, Mlacker GM, Goldberg JL. Mar 14. PubMed PMID: 23497845. regression of a choroidal metastasis secondary American Academy of Pediatrics. 2012. a three-dimensional analysis.Ophthalmology. Regulation of Set-β’s subcellular localization Tatham AJ, Weinreb RN, Zangwill LM, to breast cancer with stereotactic radiation: Kroeger H, Chiang WC, Lin JH. Endoplasmic Siegel L, Robbins SL, Retinopathy of 2012 Dec;119(12):2572-8. doi: 10.1016/j. and posttranslational modifications affect Liebmann JM, Girkin CA, Medeiros FA. Belghith A, Bowd C, Balasubramanian Case report and review of literature. Journal reticulum associated degradation (ERAD) of Khayali S, Robbins SL, Korn BS, Kikkawa Prematurity In: Challenging Cases in Pediatric ophtha.2012.06.065. Epub 2012 Aug 24. axon growth and regeneration. Estimated Retinal Ganglion Cell Counts in M., Weinreb RN, Zangwill LM. A Bayesian of Radiosurgery and Stereotactic Body mutant P23H rhodopsin in photoreceptors. DO, Facioauriculovertebral Spectrum In: Ophthal. American Academy of Pediatrics. ARVO 2473/D78. 2013. Glaucomatous Eyes with Localized Retinal framework for glaucoma progression detection Radiation Therapy. In press. Adv Exp Med Biol. 723:559-565. PMID: Challenging Cases in Pediatric Ophthal. Granet D, Baber L, Robbins SL eds. Burke TR, Fishman GA, Tsang SH, Smith T, Nerve Fiber Layer Defects. Am J Ophthalmol. using Heidelberg Retina Tomograph images. 22183378. 2012. American Academy of Pediatrics. Granet D, Elk Grove Village, IL. 2012. 267-274. Ayyagari R, Koenekoop RK, Iannaccone A, Noh YH, Kim KY, Shim MS, Choi SH, Choi SY, 2013 Jun 7. PubMed PMID: 23746612. International Journal of Advanced Computer Hodgson N, Whipple KM, Lin JH, Brumund KT, Baber L, Robbins SL eds. Elk Grove Village, Cremers FP, Klaver CC, II, Allikmets R. Retinal Ellisman MH, Weinreb RN, Perkins GA, Ju WK. Science and Applications, 4(6). In press. Kikkawa DO, Korn BS. Bilateral Squamous Cell Shinde V, Sizova OS, Lin JH, LaVail IL. 2012. 473-481. Trumler A, Robbins SL, Camras CB. Pediatric phenotypes in patients homozygous for the Inhibition of oxidative stress by coenzyme Q10 Tatham AJ, Weinreb RN, Zangwill LM, Carcinoma of the Lacrimal Sac. Ophthal Plast MM, Gorbatyuk MS. ER stress in retinal Glaucoma In: Challenging Cases in Pediatric G1961E mutation in the ABCA4 gene, Invest. increases mitochondrial mass and improves Liebmann JM, Girkin CA, Medeiros FA. Reconstr Surg, In press. degeneration in S334ter rhodopsin rats. Korn BS, Kikkawa DO, Robbins SL, Ophthal. American Academy of Pediatrics. Ophthalmol. Vis. Sci. 2012 Jul 3;53(8):4458-67. bioenergetic function in optic nerve head The relationship between cup-to-disc ratio OCULOPLASTICS AND RECONSTRUCTIVE SURGERY PLoS ONE. 7(3): e33266. Nasolacrimal Duct Obstruction In: Challenging Granet D, Baber L, Robbins SL eds. doi: 10.1167/iovs.11-9166. astrocytes. Cell Death Dis. 2013. and estimated number of retinal ganglion Hayano SM, Whipple KM, Korn BS, Kikkawa Hodgson N, Bratton E, Whipple K, PMID: 22432009. 2012. Cases in Pediatric Ophthalmology. American Elk Grove Village, IL. 2012. 93-100. cells. Invest Ophthalmol Vis Sci. 2013 May DO. Principles of Periocular Reconstruction Priel A, Oh SR, Fante RG, Kikkawa Academy of Pediatrics. Granet D, Baber L, Chan C, Chhablani J, Freeman WR: Pasquale LR, Loomis SJ, Kang JH, Yapan BL, 7;54(5):3205-14. PubMed PMID: 23557744. following Excision of Cutaneous Malignancy. DO, Korn BS. Outcomes of endonasal Mahajan VB, Lin JH. Leukocyte infiltration eds. Elk Grove Village, IL. 2012. 85-91. Bosworth RG, Robbins SL, Granet DB, Vitreoretinal surgery for no light perception Abdrabou W, Budenz DL, Chen TC, Delbono J. Skin Cancer, 2012, 438502. dacryocystorhinostomy without nasal flap in CAPN5 autosomal dominant neovascular Dobkins KR. Delayed luminance and after open-globe injury: eye injury vitrectomy E, Friedman DS, Gaasterland D, Gaaserland Wang AS, Alencar LM, Weinreb RN, preservation. Ophthal Plast Reconstr Surg, inflammatory vitreoretinopathy. Clin Mills J, Robbins SL, Pediatric chromatic contrast sensitivity in infants with study. American Journal of Ophthalmology. T, Grosskreutz CL, Lee RK, Lichter PR, Liu Y, Tafreshi A, Deokule S, Vizzeri G, Medeiros FA. Priel A, Oh SR, Whipple KM, Korn BS, In press. Ophthalmol. 7:1-7. PMID: 23861576. 2013. Blepharoconjunctivitis In: Challenging Cases spontaneously regressed retinopathy of 2012;153(4):777. McCarty CA, Moroi SE, Olson M, Realini T, Rhee Repeatability and reproducibility of Goldmann Kikkawa DO. Use of antimetabolites in the in Pediatric Ophthal. American Academy of prematurity. Doc Ophthalmol. 2013 Jun 7. DJ, Schuman JS, Singh K, Vollrath D, Wollstein applanation, dynamic contour, and ocular reconstruction of severe anophthalmic socket Pediatrics. Granet D, Baber L, Robbins eds. Chhablani J, Barteselli G, Bartsch DU, Kozak G, Zack DJ, Allingham RR, Pericak-Vance MA, response analyzer tonometry. J Glaucoma. contraction. Ophthal Plast Reconstr Surg, PATHOLOGY PEDIATRIC OPHTHALMOLOGY Elk Grove Village, IL. 2012. 33-37. Fierson WM; American Academy of Pediatrics I, Wang H, El-Emam S, Doede AL, Cheng L, Weinreb RN, Zhang K, Hauser MA, Richards JE, 2013;22:127-32. 2012, 28:409-12. Chiang WC, Hiramatsu N, Messah C, Baber L, Robbins SL, Neonatal Conjunctivitis Section on Ophthalmology; American Academy Freeman WR. Influence of scanning density Haines JL, Wiggs JL. CDKN2B-AS1 genotype- Lin JH. Selective activation of ATF6 and PERK In: Challenging Cases in Pediatric Ophthal. Narvaez J, Robbins SL, Aniridia In: Challenging of Ophthalmology; American Association for on macular choroidal volume measurement glaucoma feature correlations in primary Wang Y, Brown DP, Duan Y, Kong W, Floyd AM, Whipple KM, Lim LH, Korn BS, signaling pathways prevent mutant rhodopsin AmericanAcademy of Pediatrics. Granet D, Cases in Pediatric Ophthalmology. American Pediatric Ophthalmology and Strabismus; using spectral-domain optical coherence open-angle glaucoma patients from the United Watson BD, Goldberg JL. A novel rodent Kikkawa DO. A 55-mm Object Inside a accumulation. Invest Ophthal Vis Sci. 53(11): Baber L, Robbins SL eds. Elk Grove Village, Academy of Pediatrics. Granet D, Baber L, American Association of Certified Orthoptists. tomography.Graefes Arch Clin Exp Ophthalmol. States. Am J Ophthalmol. 2013;155:342-53. model of posterior ischemic optic 40-mm Orbit. Orbit. 2013. 7159-7166. PMID: 22956602. selected as IL. 2012. 3-7. eds. Elk Grove Village, IL. 2012. 223-228. Screening Examination of Premature Infants 2013 May;251(5):1303-9. doi: 10.1007/s00417- 50 neuropathy. Archives of Ophthalmology, Research Highlight. Cheetham ME. 2012. for Retinopathy of Prematurity. Pediatrics. 012-2188-0. Epub 2012 Nov 10. 51 Chhablani J, Barteselli G, Wang H, El-Emam Challenging Cases in Pediatric Ophthalmology, in patients with AIDS and without infectious function in intermediate, posterior and (Lond). 2012 Jun;26(6):866-71. 2012. Kozak I, Wang HY, Cheng L. Predictors Proc Natl Acad Sci U S A. 110:2377-82. 2013. Gangaputra S, Drye L, Vaidya V, Thorne JE, S, Kozak I, Doede AL, Bartsch DU, Cheng L, Granet, Robbins, Baber, American Academy retinitis. Ocular Immunology and Inflammation. panuveitis. Ocular Immunology and Arévalo JF, García RA, London NJS, of visual outcome in eyes with choroidal El Emam S, Chhablani J, Barteselli G, Wang Jabs DA, Lyon AT, Freeman WR, Studies of Freeman WR. Repeatability and reproducibility of Pediatrics, 2012. 2012;20(5):342-348. Inflammation. 2012;20(3):171-181. Cunningham Jr. ET, BelFort Jr R, Freeman WR: neovascularization secondary to age related H, Lee SN, Kozak I, Cheng L, Freeman the Ocular Complications of AIDS (SOCA) of manual choroidal volume measurements Chapter 1: Retinal and Choroidal Manifestations macular degeneration treated with intravitreal WR: Correlation of spectral domain optical Research Group: Non-cytomegalovirus using enhanced depth imaging optical Ferreyra HA, Heckenlively JR. Chapter 23: Liu X, Li Y, Zhang Y, Du W, Sun S, Lin B, Wang, H, Chhablani J, Freeman WR, of HIV/AIDS. Retinal and Choroidal bevacizumab monotherapy. Int J Ophthalmol. coherence tomography characteristics with ocular opportunistic infections in patients coherence tomography. Invest Ophthalmol Retinitis Pigmentosa. Genetic Diseases Chen H, Cheng L. Comparison of intraocular Chan CK, Kozak I, Bartsch DU and Cheng L: Manifestations of Selected Systemic Diseases. 2013;6(1):62-6. doi: 10.3980/j.issn.2222- visual acuity in eyes with subfoveal scarring with acquired immunodeficiency syndrome. Vis Sci. 2012 Apr 24;53(4):2274-80. of the Eye, 2nd Edition, Traboulsi EI, pressure elevation after anterior versus Characterization of diabetic microaneurysms Arevalo JF, Ed., Springer Science Business 3959.2013.01.13. Epub. 2013 Feb 18. after treatment for wet age-related macular American Journal of Ophthalmology. doi: 10.1167/iovs.12-9435. Oxford University Press, 2012. posterior subtenon triamcinolone acetonide by simultaneous fluorescein angiography Media, New York, 2013. degeneration. Retina. 2013;33(6):1249-1257. 2013;155(2):206-212. acetate injection: a retrospective study. and spectral-domain optical coherence Chhablani J, Bartsch DU, Cheng L, Chhablani J, Kozak IR, Mojana F, Cheng L, Grob S, Luo J, Hughes G, Lee C, Zhou X, Retina. 2012 Oct;32(9):1838-43. tomography. American Journal of Barteselli G, Bartsch DU, El Emam S, Gomez L, Alshareef RA, Rezeq SS, Garg SJ, Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Hannum G, Guinney J, Zhao L, Zhang L, Morrison VL, Wang H, Kim JS, Dustin L, Azen Lee J, Du H, Ferreyra H, Freeman WR, Ophthalmology. 2012;153(5):861-867. Gomez ML, Chhablani J, Lee SN, Burgansky-Eliash Z, Freeman WR: Segmental Thorleifsson G, Zack DJ, Arakawa S, Cipriani Hughes G, Sadda S, Klotzle B, Bibikova M, S, Freeman WR. Fundus autofluorescence not Kozak I, Zhang K. Genetic analysis of MacDonald IM, Gudiseva HV, Villanueva A, Conner L, Freeman WR: Combined depth reproducibility of retinal blood flow velocity V, Ripke S, Igo RP Jr, Buitendijk GH, Sim X, Fan JB, Gao Y, Deconde R, Chen M, Rajapakse predictive of treatment response to intravitreal simultaneous geographic atrophy and Greve M , Caruso R, Ayyagari R. Phenotype Witkin AJ, Alshareef RA, Rezeq SS, Sampat KM, imaging technique on spectral-domain optical measurements using retinal function imager. Weeks DE, Guymer RH, Merriam JE, Francis PJ, I, Friend S, Ideker T, Zhang K. Genome-wide bevacizumab in exudative age-related macular choroidal neovascularization. Eye (Lond). and genotype of patients with recessive Chhablani J, Bartsch DU, Freeman WR, Haller coherence tomography. American Journal Graefe’s Archives for Clinical and Hannum G, Agarwal A, Armbrecht AM, Audo I, Methylation Profiles Reveal Quantitative degeneration. Retina. 2012 Sep;32(8):1465-70. 2012 Aug; 26(8):1106-13. bestrophinopathy. Ophthalmic Genetics, JA, Garg SJ: Comparative analysis of the retial of Ophthalmology. 2013;155(4):727-732. Experimental Ophthalmology. 2013. Aung T, Barile GR, Benchaboune M, Bird AC, Views of Human Aging Rates. Mol Cell, doi: 10.1097/IAE.0b013e3182475aea. 33:123-9. 2012. microvasculature visualized with fluorescein Bishop PN, Branham KE, Brooks M, Brucker 49:359-67. 2013. Hartmann KI, Gomez ML, Bartsch DU, angiography and the retinal function imager. Barteselli G, Bartsch D-U, Viola F, Mojana F, Chhablani J, Nieto A, Hou H, Wu EC, Freeman AJ, Cade WH, Cain MS, Campochiaro PA, Chhablani J, Kim JS, Cheng L, Kozak I, 14 AK and Freeman WR: Effect of change Nguyen QD, Brown DM, Marcus DM, Boyer American Journal of Ophthalmology. Pellegrini M, Hartmann KI, Benatti E, Leicht S, WR, Sailor MJ, Cheng L. Oxidized porous Chan CC, Cheng CY, Chew EY, Chin KA, Hartmann KI, Nieto A, Wu EC, Freeman Freeman WR: External limiting membrane as in drusen evolution on photoreceptor DS, Patel S, Feiner L, Gibson A, Sy J, Rundle 2012;154(5):901-907. Ratiglia R, Staurenghi G, Weinreb RN, Freeman silicon particles covalently grafted with Chowers I, Clayton DG, Cojocaru R, Conley WR, Kim J, Chhablani J, Sailor MJ, Cheng L: a predictor of visual improvement in diabetic inner segment/outer segment junction. AC, Hopkins JJ, Rubio RG, Ehrlich JS; RISE WR. Accuracy of the Heidelberg spectralis in daunorubicin as a sustained intraocular drug YP, Cornes BK, Daly MJ, Dhillon B, Edwards Hydrosilylated porous silicon particles function macular edema after pars plana vitrectomy. Retina. 2012;32(8):1492-1499. and RIDE Research Group. Ranibizumab Xu Y, You Y, Du W, Zhao C, Li J, Mao J, the alignment between near-infrared image delivery system. Invest Ophthalmol Vis Sci. AO, Evangelou E, Fagerness J, Ferreyra as an intravitreal drug delivery system for Graefes Archive for Clinical and Experimental for diabetic macular edema: results from 2 Chen H, Cheng L. Ocular pharmacokinetics and tomographic scan in a model eye: 2013 Feb 1;54(2):1268-79. HA, Friedman JS, Geirsdottir A, George RJ, daunorubicin. Journal of Ocular Pharmacology Ophthalmology. 2012;250(10)1415-1420. Kim JS, Beadle JR, Freeman WR, Hostetler Phase III randomized trials: RISE and RIDE. of bevacizumab in vitrectomized eyes with A multicenter study. Am J Ophthalmol. 2013. doi: 10.1167/iovs.12-11172. Gieger C, Gupta N, Hagstrom SA, Harding and Therapeutics. 2013;29(5):493-500. KY, Hartmann K, Valiaeva N, Kozak I, Ophthalmology. 2012;119(4):789-801. silicone oil tamponade. Invest Ophthalmol SP, Haritoglou C, Heckenlively JR, Holz FG, Cukras C, Gaasterland T, Lee P, Gudiseva Conner L, Trahan J, Aldern KA, Cheng Vis Sci. 2012 Aug 7;53(9):5221-6. Barteselli G, Bartsch DU, El-Emam S, Chhablani J, Barteselli G, Bartsch DU, Kozak Hughes G, Ioannidis JP, Ishibashi T, Joseph Hu CM, Fang RH, Luk BT, Chen KN, Carpenter HV, Chavali VR, Pullakhandam R, Maranhao L. A novel cytarabine crystalline lipid Parpura V, Silva GA, Tass PA, Bennet KE, doi: 10.1167/iovs.12-9702. Gomez ML, Chhablani J, Lee SN, Conner I, Wang H, El Emam S, Doede AL, Cheng L, P, Jun G, Kamatani Y, Katsanis N, N Keilhauer C, Gao W, Zhang K, Zhang L. ‘Marker-of- B, Edsall L, Soares S, Reddy GB, Sieving prodrug: hexadecyloxypropyl cytarabine Meyyappan M, Koehne J, Lee KH, Andrews RJ. L, Freeman WR. Combined depth imaging Freeman WR: Influence of scanning density C, Khan JC, Kim IK, Kiyohara Y, Klein BE, self’ functionalization of nanoscale particles PA, Ayyagari R. Exome analysis identified 3’,5’-cyclic monophosphate for proliferative Neuromodulation: selected approaches and Yu F, Zhao B, Panupinthu N, Jewell JL, Lian technique on spectral-domain optical on macular choroidal volume measurement Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, through a top-down cellular membrane coating a novel mutation in the RBP4 gene in a vitreoretinopathy. Mol Vis. 2012;18:1907-17. challenges. Journal of Neurochemistry 10.1111/ I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li coherence tomography. Am J Ophthalmol. using spectral-domain optical coherence Lichtner P, Lotery AJ, Meitinger T, Mitchell approach. Nanoscale. 5(7):2664-8. 2013. consanguineous pedigree with retinal Epub 2012 Jul 14. jnc.12105. 2012. H, Fu XD, G. Mills, Guan KL. Regulation of the 2013 Apr;155(4):727-732.e1. doi: 10.1016/j. tomography. Graefes Archive for Clinical P, Mohand-Saïd S, Moore AT, Morgan DJ, dystrophy and developmental abnormalities. Hippo-YAP pathway by G-protein coupled ajo.2012.10.019. Epub 2012 Dec 17. and Experimental Ophthalmology. Morrison MA, Myers CE, Naj AC, Nakamura Jabs DA, Ahuja A, Van Natta M, Dunn JP, PLoS One. 2012;7(11):e50205. Kim J, Chhablani J, Chan CK, Cheng L, Shaw PX, Zhang L, Zhang M, Du H, Zhao L, receptor signaling. Cell 150(4):780-91. 2012. 2013;251(5):1303-1309. Y, Okada Y, Orlin A, Ortube MC, Othman MI, Yeh S, Freeman WR, Studies of the Ocular Kozak I, Hartmann K and Freeman WR: Lee C, Grob S, Lim SL, Hughes G, Lee J, Bedell Barteselli G, Bartsch DU, Freeman WR: Pappas C, Park KH, Pauer GJ, Peachey NS, Complications of AIDS Research Group: Duncan J, Roorda A, Navani M, Vishwesvaraiah Retinal adherence and fibrillary surface M, Nelson MH, Lu F, Krupa M, Luo J, Ouy-ang Zhang K, Ferreyra HA, Grob S, Bedell M, Zhang Combined depth imaging using optical Chhablani J, Bartsch DU, Cheng L, Poch O, Priya RR, Reynolds R, Richardson Comparison of treatment regimens for S, Syed R, Soudry S, Ratnam K, Gudiseva changes correlate with surgical difficulty H, Tu Z, Su Z, Zhu J, Wei X, Feng Z, Duan Y, JJ. Chapter 46: Diabetic Retinopathy: Genetics coherence tomography as a novel imaging Gomez L, Alshareef RA, Rezeq SS, Garg SJ, AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, cytomegalovirus retinitis in patients with AIDS H, Lee P, Gaasterland T, Ayyagari R. Exome of epiretinal membrane removal. Yang Z, Ferreyra H, Bartsch DU, Kozak I, and Etiologic Mechanisms. Retina 5th Edition, technique to visualize vitreoretinal choroidal Burgansky-Eliash Z, Freeman WR. Segmental Schaumberg DA, Scholl HP, Schwartz SG, in the era of highly active antiretroviral therapy. analysis identified a novel mutation in the American Journal of Ophthalmology. Zhang L, Lin F, Sun H, Feng H, Zhang K. Ryan, Schachat, Wilkinson, Hinton, Sadda, structures. Retina. 2013;33(1):247-248. reproducibility of retinal blood flow velocity Scott WK, Shahid H, Sigurdsson H, Silvestri G, Ophthalmology. 2013;120:1262-1270. CDHR1 gene in a family with recessive 2012;153(4):692-697. Complement factor H genotypes impact Wiedemann, Saunders, 2012. measurements using retinal function imager. Sivakumaran TA, Smith RT, Sobrin L, Souied retinal degeneration, Arch. Ophthalmol. risk of age-related macular degeneration Barteselli G, Chhablani J, Lee SN, Wang H, Graefes Arch Clin Exp Ophthalmol. EH, Stambolian DE, Stefansson H, Sturgill- Lee SN, Chhablani J, Chan CK, Wang H, 1;130:1301-8. 2012. Kim SJ, Blumling J, Davidson MC, Saad H, by interaction with oxidized phospholipids. Zhang L, Lim SL, Du H, Zhang M, Kozak I, El Emam S, Kozak I, Cheng L, Bartsch DU, 2013 May 23. PMID: 23700326. Short GM, Takahashi A, Tosakulwong N, Truitt Barteselli G, El-Emam S, Gomez ML, Kozak Eun SY, Silva GA. Calcium and EDTA Proc Natl Acad Sci USA, 2012 Aug 21; Hannum G, Wang X, Ouyang H, Hughes G, Azen S, Freeman WR: Safety and efficacy BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, I, Cheng L, Freeman WR. Characterization Fang RH, Chen KN, Aryal S, Hu CM, Zhang K, induced folding and unfolding of calmodulin 109(34):13757-62. Zhao L, Zhu X, Lee C, Su Z, Zhou X, Shaw of oral fluorescein angiography in detecting Du H, Sun X, Guma M, Luo J, Ouyang H, Vijaya L, Vingerling JR, Vithana EN, Webster of microaneurysm closure after focal laser Zhang L. (2012). Large-scale synthesis of on functionalized quantum dot surfaces. R, Ideker T, Oka C, Wang N, Yang Z, Shaw macular edema in comparison with spectral- Zhang X, Zeng J, Quach J, Nguyen DH, AR, Wichmann HE, Winkler TW, Wong TY, photocoagulation in diabetic macular edema. lipid-polymer hybrid nanoparticles using a Journal of Nanoneuroscience 2:75-81. 2012. Singer MA, Awh CC, Sadda S, Freeman WR, PX, Zhang K. HTRA1 regulates angiogenesis domain optical coherence tomography. Shaw PX, Karin M, Zhang K. JNK inhibition Wright AF, Zelenika D, Zhang M, Zhao L, Am J Ophthalmol. 2013 May;155(5):905-912.e2. multi-inlet vortex reactor. Langmuir. 39:13824-9. Antoszyk AN, Wong P and Tuomi L: HORIZON: through TGF- family member GDF6. Retina. 2013. reduces apoptosis and neovascularization Zhang K, Klein ML, Hageman GS, Lathrop GM, doi: 10.1016/j.ajo.2012.12.005. Epub 2013 Feb 6. Kozak I, Kim JS, Oster SF, Chhablani J an open-label extension trial of ranibizumab for J Biol Chem. 25;286(12):10210-5 in a murine model of age-related macular Stefansson K, Allikmets R, Baird PN, Gorin Ferreyra HA. Chapter 33: Normal retinal and Freeman WR: Focal navigated laser choroidal neovascularization secondary to age- (co-corresponding author). 2012. Blain D, Goetz K, Ayyagari R, Tumminia S, degeneration. Proc Natl Acad Sci U S A. MB, Wang JJ, Klaver CC, Seddon JM, Pericak- Lee J, Zeng J, Hughes G, Chen Y, Grob S, variants/unusual fundus color. Challenging photocoagulation in retinovascular disease related macular degeneration. Ophthalmology. eyeGENE®: a vision community resource 2013 Jan 22. PMID: 23341606. 2013. Vance MA, Iyengar SK, Yates JR, Swaroop A, Zhao L, Lee C, Krupa M, Quach J, Luo J, Zeng Cases in Pediatric Ophthalmology, Granet, - clinical results in initial case series. Retina. 2012;119(6):1175-1183. Zhao L, Grob S, Corey R, Krupa M, Luo J, facilitating patient care and paving the path for Weber BH, Kubo M, Deangelis MM, Léveillard J, Wei X, Zhang X, Zhu J, Duan Y, Ferreyra H, Robbins, Baber, American Academy of 2012;32:930-935. Du H, Lee C, Hughes G, Lee J, Quach J, research through molecular diagnostic testing. Du H, Sun X, Guma M, Luo J, Ouyang H, T, Thorsteinsdottir U, Haines JL, Farrer LA, Goldbaum M, Haw W, Shaw PX, Tang L, Zhang Pediatrics, 2012. Taylor SR, Lightman S, Sugar EA, Jaffe Zhu J, Shaw PX, Kozak I, Zhang K. A novel Clin Genet. 2013 May 10. doi: 10.1111/cge.12193. Zhang X, Zeng J, Quach J, Nguyen DH, Shaw Heid IM, Abecasis GR; AMD Gene Consortium. K. (2013) Association of LIPC and advanced Kozak I, Ahuja A, Gangaputra S, Van Natta GJ, Freeman WR, Altaweel MM, Kozak I, compound heterozygous mutation in the PMID: 23662816. PX, Karin M, Zhang K. JNK inhibition reduces Seven new loci associated with age-related age-related macular degeneration. Eye (Lond). Ferreyra HA. Chapter 37: Retinitis Pigmentosa. ML, Thorne JE, Freeman WR: Optic nerve Holbrook JT, Jabs DA, Kempen JH: BEST1 gene causes autosomal recessive apoptosis and neovascularization in a murine macular degeneration. Nat Genet. 2013 2013 Jan 25. doi: 10.1038/eye.2012.276. 52 head morphology and visual field function The impact of macular edema on visual est vitelliform macular dystrophy. Eye Chhablani J, Kim JS, Freeman WR, model of age-related macular degeneration. Apr; 45(4):433-9, 439e1-2 PMID: 23348725 53 Lee J, Zeng J, Hughes G, Chen Y, Grob S, Patients in ANCHOR, MARINA, and HORIZON: Ben Shoam A, Malkinson G, Krief S, Zhuang G, Wu X, Jiang Z, Kasman I, Yao J, Scuderi M, Batista A, Kirkpatrick ND, Ruiz de Zhao L, Lee C, Krupa M, Quach J, Luo J, Zeng A Multicenter Cohort Study (SEVEN-UP). Schwartz Y, Ely Y, Ferrara N, Yaniv K, Guo Y, Oeh J, Modrusan Z, Bais C, Sampath Almodovar C, Riedemann L, Walsh EC, Anolik J, Wei X, Zhang X, Zhu J, Duan Y, Ferreyra H, Ophthalmology. pii: S0161-6420(13)00331-X. Zelzer E. S1P1 inhibits sprouting angiogenesis D Ferrara N. Tumor secreted miR-9 promote R, Huang Y, Martin JD, Kamounn W, Knevels Goldbaum M, Haw W, Shaw PX, Tang L, Zhang doi: 10.1016/j.ophtha.2013.03.046. during vascular development. Development. endothelial cell migration and angiogenesis E, Schmidt T, Farrar CT, Vakoc BJ, Mohan K. Association of LIPC and advanced age- 139,3859-3869, 2012. by activating the JAK-STAT pathway. N, Chung E, Roberge S, Peterson T, Bais C, LECTURES related macular degeneration. Eye (Lond). Tiruvalluru M, Ananthathmakula P, EMBO J. 31, 3513-3523, 2012. Zhelyazkova BH, Yip S, Hasselblatt M, Rossig 2013 Feb; 27(2):265-70. Ayyalasomayajula V, Nappanveettil G, Chung AS, Kowanetz M, Wu X, Zhuang G, C, Niemeyer E, Ferrara N, Klagsbrun M, Duda Ayyagari R and Reddy GB. Vitamin A Ngu H, Finkle D, Komuves L, Peale FV, Brauer MJ, Zhuang G, Schmidt M, Yao J, Wu X, D, Fukumura D, Xu L, Carmeliet P, Jain RK. Lu B, Morgans C, Girman S, Luo J, Zhao J, Supplementation Ameliorates Obesity - Ferrara N. Differential drug-class specific Kaminker J, Jurinka S, Kolumam G, Chung AS, Targeting placenta growth factor/neuropilin Du H, Lim S, Ding S, Svendsen C, Zhang K, Associated Retinal Degeneration in metastatic effects following treatment with Jubb A, Modrusan Z, Phillips H, James D, 1 pathway inhibits growth and spread of NATALIE A. AFSHARI, M.D. “Advances for Corneal Surgery: Implications Research Lecture at the Nobel Forum, for Endothelial Diseases”, “A Journey Through Stockholm, Sweden, October 18, 2012. Wang S. Neural stem cells derived by small WNIN/Ob Rats, National Institute of Nutrition. a panel of angiogenesis inhibitors J. Pathol. Haley B, Clermont A, Cheng JH, Yang SX, medulloblastoma. Cell. 152, 1065-1067, 2013. “New Horizons in Fuchs Corneal Dystrophy: Cornea From A to Z”, Larry Piebenga, M.D. molecules preserve vision. Translational Vision India. 2013 Jan;29(1):298-304. doi: 10.1016/j. 227, 404-416, 2012. Swain S, Scherer S, Koeppen H, Yeh R-F, Surgical Interventions and Genetics”, University Annual Lectureship, Annual Symposium for Uppsala University Seminar, Uppsala, Science & Technology. T: January 2013, nut.2012.06.006. PMID:23036575. Choi YJ, Yue P, Stephan J-P, Hegde P, Stefater JA, Rao S, Bezold K, Aplin AC, of California Davis, Davis, CA, February 2012. Vol. 2, No. 1. Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK, Ferrara N, Singh M, Bais C. Anti-VEGF Nicosia RF, Pollard J, Ferrara N, Lang R. Residency Graduation University of Missouri, Sweden, October 19, 2012. Kansas City, MO, June 2013. Xue YC, Ouyang K, Huang J, Zhou Y, Ouyang Jeannson M, Zhang C, Tucholska M, Jones N, treatment targets a discrete and molecularly Macrophage Wnt-Calcineurin-Flt1 signaling “Advances in Corneal Surgery: Implications 91st Annual Beaumont Lecture, Luo J, Zhao L, Chen AY, Zhang X, Zhu J, H, Li H, Wang G, Wu Q, Wei C, Bi Y, Jiang L, Kerjacki D, Shibuya M, Fantus G, Gerber HP, distinguishable compartment within tumor regulates wound angiogenesis and repair. in Endothelial Keratoplasty”, Louis Young, “Practical IOL Calculations”, Ninth Annual Michigan State Medical Society, Zhao, Ouyang H, Luo H, Song Y, Lee J, Patel S, Cai Z, Sun H, Zhang K, Zhang Y, Chen J, Ferrara N, Pawson T, Quaggin SE. Soluble vasculature in mice and humans. Clin. Blood. 121, 2574-2578, 2013. M.D. Visiting Professor, Annual Symposium Harvard Medical School Intensive Cataract Troy, MI, October 26, 2012. Shaw PX, S. Sadda, Zhuo Y, Rosenfeld MG, Fu XD. Direct conversion of fibroblasts to Flt-1 regulates glomerular barrier function. Cancer Res. 19, 3681-3692, 2013. for Residency Graduation, Howard University, Surgery Training Course, Harvard University Zhang K. TCF7L2 Variation and Proliferative neurons by reprogramming PTB-regulated Cell. 151, 384-399, 2012. Rao S, Chun C, Fan J, Kpfron JM, Hegde RS, Washington, DC, June 2012. Diabetic Retinopathy. Diabetes 2013 Feb 22. microRNA circuits. Cell 152:82-96. 2013. Luo L, Uehara H, Zhang X, Das SK, Olsen T, Ferrara N, Lang RA. A melanopsin-dependent Massachusetts Eye and Ear Infirmary, Boston, 15th International Symposium on MA, June 2013. Anti-Angiogenic Agents, La Jolla, CA, Liu Y, Berendsen, AD, Jia S, Lotinun S, Holt D, Simonis JM, Jackman K, Singh N, fetal light response regulates mouse eye “Refractive Surgery in 2020: How Would We January 31 - February 2, 2013. MacDonald CL, Silva GA. A positive feedback Zhao L, Grob S, Kimera A, Pieramici D, Lee J, Baron R, Ferrara N, Olsen, BR. Intracellular Miya TR, Huang W, Ahmed F, Bastos-Carvalho development. Nature. 494, 243-246, 2013. Treat Refractive Errors Then?” and “Lipiflow “Diffuse Lamellar Keratitis” and cell signaling nucleation model of astrocyte Rabena M, Hughes G, Ortiz S, Tornambe P, VEGF regulates the balance between A, Le YZ, Mamalis C, Chiodo VA, Hauswirth Thermal Pulsation Therapy”, Ophthalmology “Postoperative Dry Eye/Corneal Neuralgia”, “Ophthalmology Update 2013”, Keynote Talk, dynamics. Frontiers in Neuroengineering 6:4. Goldbaum M, Ferreyra H, Kozak I, Zhang K. osteoblast and adipocyte differentiation. WW, Baffi J, Lacal PM, Orecchia A, Ferrara Zhong C, Wang J, Li B, Xiang H, Ultsch M, Update 2013, University of California, San Lasik Certification Course, Navy Refractive La Jolla, CA, February 16-17, 2013. doi: 10.3389/fneng.2013.00004. 2013. Common Variant in VEGFA and Response to J. Clin. Invest. 122, 3101-3113, 2012. N, Gao G, Young-hee K, Fu Y, Owen L, Coons M, Wong T, Chiang NY, Clark S, Clark Diego Shiley Eye Center, La Jolla, CA, Surgery Center, San Diego, CA, June 2013. Anti-VEGF Therapy for Exudative Age-Related Albuquerque R, Baehr W, Thomas K, Li DY, R, Gribling P, Suto E, Barck K, Corpuz R, February 2013. Neubauer AS, Langer J, Liegl R, Haritoglou Macular Degeneration. Current Molecular Qu X, Zhuang G, Yu L, Meng G, Ferrara N. Chalam KV, Shibuya M, Grisanti S, Wilson DJ, Takkar R, Lee WP, Yao J, Adams C, Kelley Vision Discovery Institute Annual Retreat, Keynote Talk, Georgia Health Sciences C, Wolf A, Kozak I, Seidensticker F, Ulbig M, Medicine. 13(6):929-34. 2013. Induction of Bv8 expression by granulocyte- Ambati J. Photoreceptor avascular privilege R, Wang W, Ferrara N. Development and “New Horizons in Corneal Endothelium and DIRK-UWE BARTSCH, Ph.D. University, Augusta, GA, March 14-15, 2013. Freeman WR, Kampik A, Kernt M: Navigated colony stimulating factor in CD11b+Gr1+ cells: is shielded by soluble VEGF receptor-1. preclinical characterization of a humanized Fuchs Dystrophy – Surgical Interventions, macular laser decreases retreatment rate Zhao J, Sun W, Cho HM, Ouyang H, Li W, Key role of Stat3 signaling. J. Biol. Chem. eLife 2, e00324, 2013. antibody targeting CXCL12. Clin. Cancer Cell Therapy & Genetics”, “A Journey through “Introduction to Scanning Laser 2013 Tumor Microenvironment Symposium, for diabetic macular edema: a comparison Lin Y, Do J, Zhang L, Ding S, Liu Y, Lu P, 287, 19574-19584, 2012. Res. 19, 4433-4445, 2013. Cornea from A to Z”, University of California, Ophthalmoscopy Imaging” and “What Mayo Clinic, Rochester, MN, April 15, 2013. with conventional macular laser. Clinical Zhang K. Integration and long distance Miller JD, Le Couter J, Strauss E, San Francisco, CA, March 2013. You Need to Know About Spectral Domain Ophthalmology. 2013;7:121-128. axonal regeneration in CNS from transplanted Singh M, Ferrara N. Modeling and predicting Ferrara N. Vascular endothelial growth Zhuang G, Yu K, Jiang Z, Chung A, Yao J, OCT” and “Introduction to Scanning Laser Turkish National Cancer Congress, Antalya, primitive neural stem cells. J Biol Chem. clinical efficacy for drugs targeting the tumor factor in intraocular vascular disease. Soriano R, Haley B, Blackwood E, Sampath “Anti-Angiogenesis Therapy: Corneal Graft Ophthalmoscopy Imaging Workshop”, Turkey, April 19-20, 2013. Nizar K, Tian P, Cheng Q, Saisan PA, Uhlirova 2012 Nov 15. milieu. Nature Biotechnol. 30, 648-657, 2012. Opthalmology. 120, 106-114, 2013. D, Bais C, Lill J, Ferrara N. VEGF-regulated Rejection Implications”, Invited Symposium 43rd Annual Educational Program of H, Reznichenko L, Weldy K, Steed TY, Sridhar phospho-proteome implicates the mTORC2- Speaker, American Society of Cataract and the Ophthalmic Photographers Society, European Brain Research Institute Symposium VB, MacDonald CL, Cui J, Sakadzic S, Boas Zhao J, Luo J, Zhang K. Is era of ocular Singh M, Couto SS, Forrest WF, Lima A, Phan V, Wu X, Cheng J, Sheng R, Chung FoxO1 axis in VEGF signaling and RTK Refractive Surgery, San Francisco, CA, Chicago, IL, November 9-13, 2013. in Memory of Rita Levi-Montalcini, Rome, Italy, DA, Beka TI, Einevoll GT, Chen J, Masliah E, regeneration near? Asia-Pacific Journal Cheng JH, Molina R, Long JE, Hamilton P, A, Zhuang G, Tran C, Song Q, Kowanetz M, reprogramming of human endothelial April 2013. Dale AM, Silva GA, Devor A. In vivo stimulus- of Ophthalmology 2(2): 71-72. 2013. McNutt A, Kasman I, Nannini MA, Reslan Sambrone A, Tan M, Meng YG, Jackson EL, cells. Science Signal. 6, ra25, 2013. April 21-22, 2013. induced vasodilation precedes astrocytic HB, Cao TC, Ho CC, Barck KH, Carano RA, Peale F, Junttila M, Ferrara N. Oncogenic RAS “Opportunities and Challenges of the NAPOLEONE FERRARA, M.D. Trans-NIH workshop on angiogenesis, calcium increase. Journal of Neuroscience Silva GA, Khraiche ML. Nanotechnologies for Foreman O, Eastham-Anderson J, Jubb AM, pathway activation promotes resistance to Academic Ophthalmologist”, The Association “Endothelial Phenotypes”, Keynote Talk, Keynote Talk, Bethesda, MD, May 20-21, 2013. 33:8411-8422. 2013. recording and stimulating from excitable cells. Ferrara N, Johnson L. Anti-VEGF antibody anti-VEGF therapy through G-CSF-induced for Research in Vision and Ophthalmology Gordon Research Conference, Il Ciocco, Discovery Medicine. In press. therapy does not promote metastasis in neutrophil recruitment. Proc. Natl. Acad. Sci. (ARVO), Clinician-Scientist Forum: How to Lucca, Italy, July 30-August 3, 2012. 21st Gifford Lecture, University of Nebraska Roberts DK, Ayyagari R, McCarthy B, genetically engineered mouse tumor USA. 110, 6079-6084, 2013. Become a Successful Clinician-Scientist, Medical Center, Omaha, NE, May 23, 2013. Xie H, Davis F, Wilensky JT. Investigating models. J. Pathol. 227, 417-430, 2012. Seattle, WA, May 2013. 5th Mayo Clinic Angiogenesis Symposium, ocular dimensions in African Americans RETINAL VASCULAR DISEASES Sampath D, Oeh J, Wayatt SK, Cao T, Minneapolis, MN, August 17-19, 2012. Korea Cancer Association Satellite Symposium, with long anterior zonules. J Glaucoma. Argaw TA, Asp L, Zhang J, Navrazhina K, Willenborg S, Lucas T, Van Loo G, Koeppen H, Robilard L, Oo CCK, Ross J, “My Technique for Performing Combined Keynote Talk, Seoul, Korea, June 14, 2013. 2013 Jun-Jul;22(5):393-7. doi: 10.1097/ Pham T, Mariani JN, Mahase S, Dutta DJ, Knipper JA, Krieg TM, Haase I, Brachvogel Zhang G, Bou-Reslan H, Vitorino P, Barck EK and CE” and “The Genetics of FECD: 7th Chinese Conference on Oncology, IJG.0b013e3182447d6c. Kramer EG, Ferrara N, Sovroniev MV, B, Hammerschmidt M, Nagy A, Ferrara N, KH, Van Bruggen N, Vijapurkar U, What Have we Learned and What Questions Beijing, China, September 6-9, 2012. John GR. Astrocyte-derived VEGF drives Pasparakis M, Eming SA. CCR2 recruits Ferrara N, Friedman LS, Carano RAD. Remain?”, Advances in Cornea Surgery HENRY FERREYRA, M.D. Rofagha S, Bhisitkul RB, Boyer DS, Sadda blood-brain barrier disruption and an inflammatory macrophage subpopulation Multi-modal microvascular imaging reveals Symposium Invited Speaker, Tissue Banks “Molecular and Cellular Mechanisms “Treatment of Diabetic Macular Edema,” SR, Zhang K; SEVEN-UP Study Group. (2013). neuropathology in inflammatory and critical for angiogenesis in tissue repair. that selective inhibition of class I PI3K is International, Santa Monica, CA, May 2013. in Angiogenesis”, FEBS Workshop:, Fall California Council of the Blind, Seven-Year Outcomes in Ranibizumab-Treated demyelinating CNS disease. J. Clin. Blood. 120, 613-625, 2012. sufficient to induce an anti-vascular response Capri, Italy, October 14-17, 2012. San Diego, CA, November 2012. 54 Invest. 122, 2454-2468, 2012. in vivo. Neoplasia. 15, 694-671, 2013. 55 WILLIAM R. FREEMAN, M.D. Congress - All India Ophthalmological Society Invited Faculty, Heed Ophthalmic Foundation “RGC Survival and Regeneration”, Invited in Strabismus (Squint Club), St. Louis, MO, Boston, MA, April 2013. “Assembly, Function and Customization of Oculoplastics Archives” UCSF Department (APAO-AIOS), Hyderabad, India, January 2013. Residents Retreat, Cleveland, OH, Speaker, Medical College of Wisconsin, September 2012. Visual Circuits”, McGill University, Center for of Ophthalmology, San Francisco, CA “Update on HIV Retinal Disease”, American October 2012. Milwaukee, WI, April 2013. “Nystagmus”, Invited Speaker, Resident Research in Neuroscience Seminar Series, October 11, 2012. Uveitis Society, Park City, UT, January 2012. “Retina: Update on Diabetic Retinopathy”, “Double Vision/Strabismus Surgery”, Invited Didactic Lecture Series, University of California, Montreal, Canada, March 13, 2013. Invited Lecturer, Ophthalmology Update 2013, “Transplantation and Regeneration”, “Biomarkers in Glaucoma” and “Unmet Needs Speaker, Graves Disease & Thyroid Foundation San Diego, Department of Ophthalmology, “Eyelid Reconstruction”, Invited Speaker, “New Approaches to Medical and Surgical University of California, San Diego, La Jolla, NanoSymposium Chair, Society for in Glaucoma”, Invited Faculty, “Beyond IOP” Annual Meeting, San Diego, CA, October 2012. La Jolla, CA, May 2013. Memorial Sloan-Kettering Cancer Center, “Cases from the UCSD Oculoplastics Archives”, Therapies” and “Changing Treatments for CA, February 2013. Neuroscience Annual Meeting, CME Meeting, San Francisco, CA, April 2013. Neurobiology Seminar Series, New York, NY, Resident Lecture, Singapore National Eye Choroidal Neovascularization”, Invited Lecturer, San Diego, CA, October 2012. “Reading and Learning”, Invited Speaker, “Reading and Learning”, Invited Speaker, April 11, 2013. Center, Singapore, November 28, 2012. Ophthalmology Update, San Diego, CA, “Stem Cells for Glaucoma”, Society for Brain California Association of Orientation & Mobility Teachers of the Visually Impaired and Deaf & February 2012. JEFFREY L. GOLDBERG, M.D., Ph.D. “Survival and Regeneration in the Visual Mapping and Therapeutics, Baltimore, MD, Specialists Annual Meeting, San Diego, CA, Hard of Hearing Program, South Bay Union NYC Vision Seminar Series “The Art and Science of Orbital Surgery”, System”, Invited Lecturer, Burke Medical May 2013. November 2012. School District, Chula Vista, CA, May 2013. (Columbia, NYU, Cornell, SUNY Optometry), Invited Speaker Grand Rounds, Singapore “Systemic Versus Local Therapy of Uveitis”, “Neuroprotection of the Retina and the Optic Research Institute, Cornell/Weill School of May 20,2013. National Eye Center, Singapore, Case Discussions, Invited Lecturer, Retinal Nerve Head: Bench to Bedside”, Euretina Medicine, New York, NY, October 2012. “Optic Nerve Regeneration and “Strabismus”, Invited Speaker, University “How to be a Superhero”, Invited Speaker, November 28, 2012. Disease Summit, Newport Beach, CA, Society Winter Meeting, Symposium Speaker, Neuroprotection” and “Vision Restoration: of California, San Diego, Department of University of California, San Diego, Department “Customizing Neural Circuits to Perform March 2012. Rome, Italy, January 2012. “Survival and Regeneration in the Visual Regenerative Medicine in Ophthalmology”, Ophthalmology, Pediatric Grand Rounds, of Ophthalmology, Surgery Center staff, Specific Visual Functions”, Cell Press “Lower Blepharoplasty”, Invited Speaker, System”, Invited Speaker, Wilmer Eye Institute, Invited Faculty, Fox Center/UPMC Meeting, La Jolla, CA, February 2013. La Jolla, CA, June 2013. Symposium: Genes, Circuits and Behavior, “Failed DCR – What’s Next?”, “Pearls in Lectures on ocular drug delivery and new “Nanotechnology in Biomedicine: Imaging”, Johns Hopkins, Baltimore, MD, Pittsburgh, PA, June 2013. Toronto, Canada, June 3-5, 2013. Implanting Jones Tubes”, “Botox and Filler treatments and approaches to retinal imaging, Nature Miami Winter Symposium, Session November 2012. “How to Be a Superhero”, Invited Speaker, “Restrictive Strabismus: Thyroid”, Invited Injections – Pearls and Pitfalls”, “Update Visiting Professor, University of Pennsylvania, Chairman, Miami, FL, February 2012. “Anti-Glaucoma Medications Beyond IOP” and Lunch N Learn, University of California, International Speaker, The 15th National on Endoscopic Browlift”, “Strategies in Philadelphia, PA, May 2012. “RGC Axon Survival and Regeneration”, “Direct Delivery of Neuroprotective “Retinal Ganglion Cells in Glaucoma: Bench San Diego, Department of Ophthalmology, Congress of Pediatric Ophthalmology & DON O. KIKKAWA, M.D. Dealing with the Contracted Socket”, Glaucoma Therapy”, American Academy of to Bedside”, Invited Faculty, World Glaucoma La Jolla, CA, February 2013. Strabismus, Chinese Ophthalmological Society, “Insights into Orbital Decompression”, “Navigated Laser Therapy in Combination Symposium Speaker, American Glaucoma “Masters Symposium Asian Eyelid Ophthalmology, Chicago, IL, November 2012. Congress, Vancouver, Canada, July 2013. Tianjin, People’s Republic of China, June 2013. Oculoplastic Instructional Course, with Anti-VEGF in Diabetic Macular Edema”, Society, Washington, DC, March 2012. Rejuvenation”, Moderator, “The Science of “Update on Thyroid Eye Disease”, Invited Singapore National Eye Center, Singapore, American Society of Retina Specialists, Las Periorbital Aging”, Invited Speaker, Vegas World Stem Cell Summit, Invited Speaker, Speaker and Moderator, University of November 30-December 1, 2012. Vegas, NV, August 2012. Invited Speaker, University of California, Cosmetic Surgery 2012. An International San Diego, Hamilton Glaucoma Center, Palm Beach, FL, December 2012. DAVID B. GRANET, M.D. California, San Diego, Ophthalmology Update CHRIS W. HEICHEL, M.D. Multispecialty Syposium. Las Vegas, NV 2013 Annual Meeting, La Jolla, CA, “Multidisciplinary Treatment of Thyroid “History of Ocular Infections” and “CMV La Jolla, CA, April 2012. “Strabismus”, Invited Speaker, Basic Science “Update on DSAEK” and “Post-Refractive June 7-8, 2012. “Why Glaucoma Biomarkers?” New Horizons February 2013. Orbitopathy”, “The Art and Science of Retinitis”, Invited Lecturer, American Academy Lecture Series for Residents, University Surgery IOL Power Calculations”, Forum, Invited Faculty, San Francisco, CA, Orbital Surgery”, “Ten Minute Ptosis Repair”, of Ophthalmology, Chicago, IL, Invited Speaker, Vanderbilt Eye Institute, of California, San Diego, Department of Ophthalmology Update 2013, La Jolla, CA, “Pediatric Orbital Disorders”, Moderator, January 2013. “Thyroid Orbitopathy”, Invited Speaker, “Endoscopes in Oculoplastic Surgery”, November 2012. Nashville, TN, April 2012. Ophthalmology, La Jolla, CA, June 2012. February 2013. “How the Orbital Surgeon Can Help or Hurt University of California, Davis Health Ocular Alignment”, Invited Speaker, Thyroid “Management of Anophthalmic Socket “NT-501 CNTF Implant for Glaucoma and System Eye Center, Pediatric Grand Rounds, Contraction”, Invited Speaker, Saudi “Update on Retinal Diseases and Treatments”, “Nanoparticles and Neurotrophins: Engineering “Strabismus and Pediatric Ophthalmology”, Eye Disease Session, 2nd World Congress NAION: Phase 1 Data”, Glaucoma 2.0, Bench Sacramento, CA, March 2013. Ophthalmology 2013 (SO-2013), combined Visiting Professor, Hadassah University Medical Regeneration”, Invited Speaker, Fox Center/ Invited Speaker, Introduction to Clinical ANDREW D. HUBERMAN, Ph.D. of Pediatric Ophthalmology, Milan, Italy, to Bedside (CME), Invited Faculty, Miami, FL, meeting of the 30th Annual Symposium of the Center, Jerusalem, Israel, November 2012. McGowan Institute, Regenerative Medicine Medicine MS2 Lecture Series, University of “Wiring Visual Circuits to Perform Specific September 7-9, 2012. in Ophthalmology Conference, Pittsburgh, PA, January 2013. California, San Diego, School of Medicine, “Vision, Learning and Reading: Do the Eyes Functions”, Gordon Research Conference on King Khaled Eye Specialist Hospital and the Have It?”, Invited Speaker, University of 25th Annual Scientific Meeting of the Saudi “Update on Retinal Diseases and Treatments” May 2012. June 2012. Neural Development, Newport, RI, “Congenital Ptosis”, “Chronic Dacryocystitis”, Glaucoma 2.0, Bench to Bedside, Miami, FL, California, Davis Health System Eye Center, Ophthalmologic Society, Riyadh, Saudi Arabia, Visiting Professor, King Khaled Eye Specialist August 12-17, 2012. “Enucleation Implants”, “Basal Carcinoma Course Co-Director, January 2013. Pediatric Grand Rounds, Sacramento, CA, March 3-6, 2013. Hospital, Riyadh, Saudi Arabia, Invited Lecturer, Attendant to thesis defense, “Retinoscopy and Refractions”, Invited Speaker, and Malignant Melanoma”, “Surgery vs. March 2013. November 2012. Fudan University Medical School/EENT University of California, San Diego, Department “Assembling Circuits for Delivering Specific Observation. Surgical Timing of Orbital Hospital, Shanghai, May 2012. “KLFs in Axon Regeneration”, University of of Ophthalmology, La Jolla, CA, July 2012. Qualities of Visual Information to the Brain”, Fractures”, “Blepharoplasty”, “Brow Lifts: “Complications of Blepharoplasty”, Maryland Chemistry-Biology Interface Program, “A Complex Case of Myopic Fixus”, Invited “Pearls of Blepharoplasty”, “Transconjunctival “Advances in Retinal Research: INCF Workshop on Neuroinformatics, Internal, External, Coronal, Pre-trichial, Endo”, Invited Faculty, College Park, MD, Speaker, Annual Meeting of the American Fat Redraping”, “Treatment of Lower Lid Nanotechnology & Future of Retinal Diseases”, “Retinal Ganglion Cell Development and “Thyroid Associated Orbitopathy”, “Improving Munich, Germany, September 12, 2012. “Orbicularis Extirpation”, “My Favorite Secret February 2013. Association for Pediatric Ophthalmology & Retraction,” “Injectables: A Replacement for “Management of Diabetic Macular Edema Regeneration”, Cogan Award Lecture, Strabismus Surgical Outcomes in Thyroid Eye Pearls”, Invited Speaker 2012 Oculofacial Strabismus (AAPOS), Boston, MA, April 2013. Surgery?”, Invited Speaker, 36th International (DME): Basics to 2013”, “Pathomechanisms ARVO, Seattle, WA, May 2012. Disease” and “Brown Syndrome: What We “Genetic Approaches to Probing Visual Plastic Surgery Conference, University of Invited Participant, NEI Audacious Goals, Symposium of Ophthalmology Moacyr and Molecular Basis of DME”, “Modern Know Now”, Invited International Chair: Circuit Development, Disease, and Function”, Illinois Eye and Ear Infirmary, Chicago, IL Bethesda, MD, February 2013. “Surgical Pearls”, Invited Speaker, Annual Álvaro - SIMASP 2013, Sao Paolo, Brazil, Day Perspectives on the Use of Dyes in VR “RGC Survival and Regeneration: Electrical 2nd World Congress of Paediatric Neurobiology Seminar Series, University of Sept 14, 2012. Meeting of the American Association for March 7-10, 2013. Surgery”, “Use of Image Registered Raster Activity and Adenylate Cyclases” and Ophthalmology & Strabismus (WCPOS), Louisville, KY, December 13, 2012. “Glaucoma: Neuroprotection”, Ophthalmology Pediatric Ophthalmology & Strabismus Scanning SD OCT to Facilitate 25 Gage ERM “Regenerative Medicine in Glaucoma”, Milan, Italy, September 2012. “Bridging the Gap in International Oculoplastic Update (CME), Invited Faculty, San Diego, CA, (AAPOS), Boston, MA, April 2013. Invited Speaker, III Congreso International de Removal”, “Imaging Retinal Vasculature and Invited Speaker, Vanderbilt Eye Institute, Johns Hopkins, Department of Neuroscience Surgery: What Can We Learn from Each February 2013. la Asociacion Colombiana de Cirugia Plastica Disease: SD-OCT”, “Updates on Diagnosis and Nashville, TN, September 2012. “Battle of the Bulge”, Invited Speaker, Seminar Series, Baltimore, MD, Feb 28, 2013. Other?”, Invited Speaker, Tongren Eye Center “Brown Syndrome Treatment: A Video Review” Ocular. Cali, Colombia, May 23-24, 2013 Treatment of Macular Diseases: Vitreo Macular The Association for Research in Strabismus 10th Anniversary Symposium, Beijing, China, “Neural Regeneration and Cell Therapies”, and “Paradoxic Pupils-A Video Demonstration”, Traction Syndrome”, Invited Lecturer, 28th “Axon Guidance Synapse Formation & (Squint Club), St. Louis, MO, September 2012. “Customized Direction Selective Visual Circuits September 22-23, 2012. Invited Faculty, American Glaucoma Society Invited Speaker, Annual Meeting of “Use of Neurotoxins in Thyroid Eye Disease”, Asia-Pacific Academy of Ophthalmology Regeneration”, Session Chair, Cold Spring that Perform Specific Functions”, Janelia Farm/ Annual Meeting, San Francisco, CA, the American Association for Pediatric Invited Speaker, International Thyroid Eye Harbor Labs, Cold Spring Harbor, NY, “Strabismus in Thyroid Orbitopathy”, HHMI, Meeting on: Insect Vision, Ashburn, VA, “The Art and Science of Orbital Surgery”, 56 September 2012. March 2013. Invited Speaker, The Association for Research Ophthalmology & Strabismus (AAPOS), March 3-6, 2013. Invited Speaker, “Cases from the UCSD 57 Disease Society, Vancouver, British Columbia, “Complex Eyelid Reconstructions”, “Interesting Cases from an Inpatient (Measurement and Significance) Symposium, “Innovations in Risk Assessment for Glaucoma Program, Pediatricians/Optometrists/Nurses/ Neuro-Ophthalmology Course – the Royal “High Density Optoelectronic Nanowire Array Canada, June 28-29, 2013. “Converting to Endoscopic Lacrimal Surgery”, Ophthalmology Service”, San Diego Eye Bank Vancouver, Canada, July 19, 2013. Patients”, Faculty, 41st Annual Ophthalmology Medical Assistants, June 2013. Australian and New Zealand Collage of Selective Stimulation of the Neural Retina: “Management of Thyroid Orbitopathy” Keynote Ophthalmic Seminar, San Diego, CA, Alumni Meeting, SUNY Downstate Medical Ophthalmologists 44th Annual Scientific Comparison with Other Neural Stimulation Speaker, Northwest Inaugural Oculoplastic August 3, 2013. Center, New York, NY, June 2013. “Retinopathy of Prematurity”, UC San Diego Congress, Melbourne, Australia, Technologies” Society for Neuroscience, BOBBY KORN, M.D., Ph.D. and Orbital Disease Teaching Course. FELIPE A. MEDEIROS, M.D., Ph.D. Ophthalmology Residents, San Diego, CA, November 25-28, 2012. San Diego, CA, November 2013. “Orbital Reconstruction in Craniofacial Xi’An Number 4 Hospital, Xi’An China. “Ocular Emergencies”, UC San Diego “Measuring Glaucoma Progression”, “Detecting Glaucoma Progression in July 2013. Syndromes”, Invited Speaker, World Congress September 20, 2013. Department of Emergency Medicine Keynote Speaker, MSD Glaucoma Symposium, Clinical Practice” and “Continuous 24 Hour “Neuro-Ophthalmic Diagnoses You Do ROBERT N. WEINREB, M.D. of Pediatric Ophthalmology and Strabismus, Orientation, San Diego, CA, August 2013. Busan, South Korea, September 2012. IOP Measurement Faculty, 41st Annual Not Want To Miss”, Invited Guest Speaker, “Mechanisms of Glaucoma Surgery”, Milan, Italy, September 12, 2012. “Complications of Blepharoplasty.” Invited Ophthalmology Alumni Meeting, SUNY PETER J. SAVINO, M.D. Ophthalmology Update 2013, La Jolla, CA., European Glaucoma Society Keynote Lecture, Speaker, Nashville Academy of Ophthalmology. “Can We Better Assess Quality of Life Downstate Medical Center, New York, NY, “Neuro-ophthalmology Review”, Invited Guest February 16-17, 2013. Copenhagen, Denmark, June 2012. “Fundamentals of Ophthalmic Plastic and Nashville, TN. October 28, 2013. JAMES D. LINDSEY, Ph.D. Outcomes?”, Faculty, Glaucoma Research June 2013. Speaker, Wills Eye Institute Review Course, Reconstructive Surgery Course”, Visiting “The Role of RGC Mitochondria in Society Meeting, Wurzburg, Germany, Philadelphia, PA, March 7, 2012. “Do You Need to Biopsy Suspected Giant “Unmet Needs of Glaucoma”, Founders Professor, Sheikh Khalifa Medical Center, “Flap Techniques and Eyelid Reconstructions.” Glaucomatous Optic Neuropathy”, September 2012. “Biomarkers and Surrogate Endpoints in Cell Arteritis?”, “Protocol for Pseudotumor Award Lecture, Optometric Glaucoma Society, Abu Dhabi, UAE, October 28-31, 2012. Invited Speaker, Department of Ophthalmology, “Neuroprotection & Apoptosis of RGCs Glaucoma”, “Should IOP Be Lowered When “Evaluation of the Patient with Diplopia”, Cerebri”, “Do Not Treat Non-Arteritic Ischemic Phoenix, AZ, October 2012. Vanderbilt University, October 29, 2013. in Glaucoma”, World Glaucoma Congress, “Structural and Functional Tests in Glaucoma”, the Only Measured Abnormality is RNFL “Pseudotumor Cerebri- Diagnosis and Optic Neuropathy”, “Masqueraders in Neuro- “Controversies – Endonasal DCR”, Invited Vancouver, Canada, July 2013. Faculty, Beyond IOP Symposium, Review of Thinning on Optic Nerve Imaging?”, Management”, “Giant Cell Arteritis”, Ophthalmology”, Invited Guest Speaker, VIII “Translating Neuroprotection into a Speaker, Oculofacial Subspecialty Conference, Ophthalmology, Chicago, IL, September 2012. “Combining Structure and Function for “Non-Arteritic Ischemic Optic Neuropathy- Curso de Actualizacion en Neuro-oftalmologia, Clinical Trial”, Joseph M. Bryan Lecture, American Academy of Ophthalmolgy, Chicago, “Innovative Approaches to Retinal Imaging in Detection of Glaucoma Progression” and To Treat Or Not To Treat”, “Clinical Case Madrid, Spain, February 22-23, 2013. JEFF LEE, M.D. Duke University School of Medicine, IL, November 10, 2012. Rodents”, “Of Mice and Men: What Can Animal “Incorporating Structural Rate of Change”, “Current Challenges in Glaucoma Clinical Presentations”, Invited Guest Speaker, Curso “Ophthalmology for the Internist Part I”, North Carolina, October 2012 Models Teach us About Glaucoma?”, World Faculty, American Academy of Ophthalmology, Research”, Faculty, 5th World Glaucoma Internacional de Actualizacion Oculoplastica UCSD Internal Medicine Noon Conference, “Best of Grand Rounds – A Postop Day Glaucoma Congress, Vancouver, Canada, Glaucoma Subspecialty Day 2012, Chicago, IL, Congress, Vancouver, Canada, July 2013. de cara al future, Instituto de Oftalmologia, GABRIEL SILVA, Ph.D. San Diego, CA, May 17, 2012. “The Case for Angle Surgery”, Fred C. Williams, #0 Surprise”, Invited Speaker, Asia Pacific July 2013. November 2012. Mexico, DF, March 22-24, 2012. “Theoretical, Computational and Experimental M.D. Memorial Lecture, 54th Annual Scientific Academy of Ophthalmology 2013, “What Can We Learn from Counting Ganglion Considerations for Mapping Dynamic Neural “Ophthalmology for the Non-Ophthalmologist Meeting of Frederick C. Cordes Eye Society, Hyderabad, India, January 17, 2013. “A Paradigm Shift in the Detection of Glaucoma Cells?”, 2013 Loris and David Rich Lecture, “Transient Visual Obscurations”, Invited Guest Network Connectivity”, q-Bio Summer School, Part II”, American Professional Coders Society, University of California, San Francisco, CA, JOHN HK LIU, Ph.D. Progression” and “Let’s Get Real: Testing what University of Alabama at Birmingham, AL, Speaker, 28th Singapore-Malaysia Joint Biocircuits Institute, University of California, San Diego Branch Meeting, San Diego, CA, March 2013. “Controversies – Best Implant for Orbital Really Matters in Glaucoma”, Keynote Speaker, August 9, 2013.. Meeting in Ophthalmology, Singapore, San Diego, CA, July 30, 2012. May 23, 2012. “Clinical Trials of Ophthalmic Drugs Fracture Repair”, Invited Speaker, Asia Pacific and Devices for Glaucoma Management”, Sixteenth Rotterdam Glaucoma Symposium, June 15-16, 2012. “Continuous 24-hr Monitoring of IOP”, Academy of Ophthalmology 2013, Biomedical and Clinical Research Seminar Rotterdam, Netherlands, January 2013. “What we Currently Understand about “Ophthalmology for the Internist Part II”, Kapetansky Lecture, University of Pittsburgh Hyderabad, India, January 18, 2013. Series, UCSD Hillcrest campus, SHIRA ROBBINS, M.D. “Double Vision - When Is It Dangerous?”, the Interface between Nanoscale Technologies UCSD Internal Medicine Noon Conference, School of Medicine, Pittsburgh, PA, San Diego, CA, April 4, 2012. “Glaucoma Progression in Clinical Practice” “Retinopathy of Prematurity”, UC San Diego Invited Guest Speaker, Neuro-Oftalmologia: and Neural Cells”, Nanotechnology San Diego, CA, June 14, 2012. September 2013. “Fillers and Neurotoxins: New Approaches and “When to Advance Treatment”, Faculty, Ophthalmology Residents, San Diego, CA A basic and update course, Conegliano, Italy, Approaches to Manipulating and Monitoring to Medical and Surgical Therapies”, Invited “Intraocular Pressure: New Perspectives”, Managing Glaucoma: Beyond Intraocular July 2012. October 13, 2012. Neural Properties Symposium, Society New Resident Orientation, UC San Diego “The RGC Index to Diagnose and Monitor Speaker, Ophthalmology Update 2013, Optometric Glaucoma Society 11th Annual Pressure Symposium, San Francisco, CA, for Neuroscience (SFN) Annual Meeting, Department of Ophthalmology, Glaucoma”, Keynote Lecture, 36th Annual San Diego, CA, February 16, 2013. Scientific Meeting, Phoenix, AZ, April 2013. “Vision Screening in Young Children”, Child “Giant Cell Arteritis”, Invited Guest Speaker, New Orleans, LA, October 13-17, 2012. San Diego, CA, July 2, 2012. Midwest Glaucoma Symposium, October 23, 2012. Health and Disability Prevention Program, Ask the Expert Program, Wills Eye Institute, Pittsburgh, PA, September 2013. “Endoscopic Lacrimal Surgery”, Invited “The Future of Glaucoma”, “What Can We Pediatricians/Optometrists/Nurses/Medical American Academy of Ophthalmology Meeting, “Opportunities and Challenges of “Cataract Complications”, CORE West Cataract Speaker, National Oculoplastic Course, Learn from Counting Ganglion Cells”, “New Assistants, October 2012. Chicago, IL, November 11, 2012. Commercializing Nanotechnologies Aimed at Surgery Training Course, Carlsbad, CA, “Nocturnal and Diurnal IOP”, Optometric Xiamen City, China, March 31, 2013. Perspectives on 24h IOP Measurements” and Treating Neurological Disorders”, The Business December 7-9, 2012. Glaucoma Society – American Academy of LINDA ZANGWILL, Ph.D. Optometry Joint Symposium, Phoenix, AZ, “Corneal Biomechanics in Glaucoma”, Keynote “Children’s Eyes: Developmental and Disease “Horner Syndrome - Con In Pro/Con of Nanotechnology Symposium, Materials “Métodos de Evaluación Estructural Aplicados “Ophthalmic Plastic and Reconstructive October 24, 2012. Speaker, South African Glaucoma Congress, States”, California Association of Orientation Format for Pharmacologic Localization”, Research Society (MRS) annual meeting, “It’s not that Big of a Deal”, Ophthalmologic a la Clínica Diaria: La Visión de Una Experta”, Surgery”, Invited Speaker, San Diego County George, South Africa, May 2013. and Mobility Specialists Statewide Conference, Invited Guest Speaker, North American Boston, MA, November 26-30, 2012. Case Presentation: UCSD MBB2 Medical XXXI Congreso Mexicano de Oftalmologia, Optometric Society Annual Meeting, “Visual Impairment in American Astronauts”, San Diego, CA, November 2012. Neuro-Ophthalmology Society Symposium, School Core Curriculum Year 2, Guadalajara, Mexico, June 10, 2012. San Diego, CA, March 21, 2013. “The 10 Commandments of Glaucoma”, American Academy of Ophthalmology Meeting, “Nanotechnology Approaches for San Diego, CA, January 4, 2013. National Taiwan University Hospital, Department of Ophthalmology, Taipei, Taiwan, Keynote Speaker, 46 Reunion Annual Sociedad “Pediatric Ophthalmology and Strabismus”, Chicago, IL, November 12, 2012. Neurostimulation and Restoring Function”, “Stratification of Normative Data”, Food and “Management of Lacrimal and Orbital January 8, 2013. Dominicana de Oftalmologia, Punta Cana, OKAP Review Session, UC San Diego Graduate Program in Neurosciences, Invited “Ophthalmologic Principles and Syndromes”, Drug Administration-American Glaucoma Diseases”, Visiting Professor, Beijing Tongren Dominican Republic, June 2013. Ophthalmology Residents, San Diego, CA, “Giant Cell Arteritis”, Invited Guest Speaker, Speaker as chosen by the graduate students UCSD MBB2 Medical School Core Curriculum Society Workshop on the Validity, Reliability Eye Hospital, Capital Medical University, China, “Intraocular Pressure: New Measuring Devices March 2013. North American Neuro-Ophthalmology Society in the program, University of Minnesota, Year 2, San Diego, CA, January 9, 2013 and Usability of Glaucoma Imaging Devices, April 3, 2013. and Instrumentation”, Optometric Glaucoma “Detecting Glaucoma Progression: A Paradigm Medical Malpractice Program, American Minneapolis, MN, April 12, 2013. Bethesda, MD, October 5, 2012. Shift”, “Advances in 24h IOP Measurement” “How to Read a Strabismus Montage”, 3 Academy of Ophthalmology Meeting, “Ophthalmologic Disorders”, UCSD MBB2 Society/American Optometric Association “Challenging Cases in Oculoplastic Surgery.” Course, San Diego, CA, June 28, 2013. and “Let’s Get Real: Testing What Really lecture series, UC San Diego Ophthalmology Chicago, IL, November 12, 2012. “A Roadmap for Translational Nanomaterials Medical School Core Curriculum Year 2, “Assessment of Structural Damage and Invited Speaker, Grand Rounds, Division of Matters in Glaucoma”,Keynote Speaker, Residents, San Diego, CA, May 2013. and Technologies Aimed at Restoring San Diego, CA, January 11, 2013. Progression”, Consejo Mexicano De Plastic Surgery, UC San Diego, CA, “What Have We Learned About IOP During 20 IV Congreso Sociedad Iberoamericana de “Nystagmus”, Clinical Symposium - Neurological Function”, Invited plenary lecture, Oftalmologia, Colegio Mexicano de July 31, 2013. Years from the Sleep Laboratory?”, 5th World Glaucoma, Punta Cana, Dominican Republic, “Vision Screening in Young Children”, Case Presentations, Invited Participant BioCom 2013, Perth, Australia, September Glaucoma, Acapulco, Mexico, May 2, 2013. 58 Glaucoma Congress, IOP Around the Clock June 2013. Child Health and Disability Prevention in Neuro-Ophthalmology Symposium and 29-October 3, 2013 59 “Glaucomatous Progression in the African “Genetics and Epigenics of Retinal Deseases”, Descent and Glaucoma Evaluation Study the 20th Medical Retina Group Meeting, (ADAGES)”, Zangwill LM, Khachatryan N, Jain S, Oxford, UK, July 2013. He F, Medeiros FA, Bowd C, Lisboa R, Weinreb RN, Liebmann JM, Girkin CA. ARVO Annual “Epigenetics in Aging and Eye Diseases”, CLINICAL TRIALS Meeting, Abstract 2655. Seattle, WA, Gordon Institute, University of Cambridge, UK, May 5-9, 2013. July 2013.

“New Ideas in Structure-Function Mapping”, “An Integrated Approach to Eye Research American Optometric Society Annual Meeting, and Therapy”, Department of Ophthalmology, GLAUCOMA Comparative Study of the Nidek Optical CNTF Implant for Glaucoma: A Phase I Topcon DRI OCT-1 Optical Coherence Function Imager (RFI 3000 System). Protocol VGFT-OD 0910: An Open- Coherence Tomography RS-3000 and Study (Prospective Clinical Trial). Tomography System for the Acquisition PI: Felipe Medeiros, M.D., Ph.D. Label, Long-Term, Safety and Tolerability San Diego, CA, June 28, 2013. Stanford University, Stanford, CA, Study to Assess Rapid Disease Progression the RTVue OCT Predicate Device for PI: Jeffrey L. Goldberg, M.D., Ph.D. of Retinal Thickness Measurements and Extension Study of Intravitreal VEGF September 2013. by Clinical and Genetic Factors in Glaucoma the Measurements of Retinal and RNFL Ocular Images of the Posterior Chamber: Trap-Eye in Neovascular Age-Related “Comparing the Rate of Rim Area Change Patients that are High Risk (STARFISH). Thickness, Optic Disc Analysis, Pachymetry, CNTF Implant for Ischemic Optic Neuropathy: Agreement and Precision Study. RETINA Macular Degeneration. in Eyes with Visual Field and Optic Disc “Genetics, Epigenetics and Stem Cell PI: Robert N. Weinreb, M.D. Endpoints: The Confocal Scanning Laser Based Approach in Age Related Macular Anterior Chamber Imaging and SLO Imaging. A Phase I (Prospective Clinical Trial). PI: Felipe Medeiros, M.D., Ph.D. Age-Related Eye Disease Study 2 (AREDS2). PI: William R. Freeman, M.D. PI: Robert N. Weinreb, M.D. PI: Jeffrey L. Goldberg, M.D., Ph.D. Ophthalmoscopy Ancillary Study to the Degeneration”, Plenary Lecture, International Contribution of Genotype to Glaucoma PI: Henry A. Ferreyra, M.D. An Open Label (Stage 1) and Randomized A Double-Masked, Randomized, Active- Ocular Hypertension Treatment Study”, Society of Ocular Cell Biology Conference, Phenotype in African Americans. Nidek Advanced OCT/SLO Systems, The Role of Retinal Nerve Fiber Layer (Stage 2), 24-Month Study of Safety and Controlled, Phase III Study of the Efficacy World Glaucoma Congress, Vancouver, Oxford, England, September 2013. PI: Robert N. Weinreb, M.D. Home Vision Monitoring in AREDS2 for Canada, July 17-20, 2013. RS-3000 Nomative Data Collection Optical Coherence Tomography Data to Efficacy of Bimatoprost Drug Delivery Progression to Neovascular Age-Related and Safety of Intravitreal Administration Study. PI: Robert N. Weinreb, M.D. Predict Future Visual Field Loss in Patients System in Patients with Open-Angle of VEGF Trap-Eye in Patients with Diabetic “Basic Research and Translational Applications Evaluation of Driving Simulator and Behind the Macular Degeneration (AMD) Using the with Glaucoma – Chart Review. Glaucoma or Ocular Hypertension. Macular Edema. PI: William R. Freeman, M.D. “Should We Have a Normative Database Based of Stem Cells”, Annual Meeting of Chinese Wheel (On-Road) Performance in Patients ForeseeHome Device (Sub-Study of AREDS2). Phase II Open Label Study Assessing the PI: Jeffrey L. Goldberg, M.D., Ph.D. PI: Felipe Medeiros, M.D., Ph.D. on Ethnicity?” World Glaucoma Congress, Ophthalmology Society, Xiamen, China, with Glaucoma and Healthy Controls. PI: Henry A. Ferreyra, M.D. Safety and Ocular Hypotensive Efficacy Multicenter Uveitis Steroid Treatment Vancouver, Canada, July 17-20, 2013. September 2013. PI: Robert N. Weinreb, M.D. of AR-12286 in Patients with Open-Angle Efficacy of 24-Hour Intraocular Pressure Structural Changes in the Eye Tissue Processing and Confocal Microscopy. (MUST) Trial. PI: William R. Freeman, M.D. Glaucoma or Ocular Hypertension. Fluctuation Recording with the SENSIMED Following Glaucoma Surgery. “Assessing Structural Change in Glaucoma”, Structural Changes in the Eye Following PI: William R. Freeman, M.D. PI: Robert N. Weinreb, M.D. Triggerfish® Contact Lens Sensor. PI: Felipe Medeiros, M.D., Ph.D. Characterization of AIDS Associated Women in Ophthalmology Conference, Glaucoma Surgery. PI: Robert N. Weinreb, M.D. Aspen, Colorado, August 1-4, 2013. PI: John H.K. Liu, Ph.D. A Double-Masked, Randomized, Active- Retinopathy in the HAART Era. Amblyopia: Structural Maintenance and Critical Evaluation of Driving Simulator and Behind PI: William R. Freeman, M.D. 24-Hour Intraocular Pressure (IOP) Patterns of Controlled Study of the Efficacy, Safety, Period Plasticity (Prospective Clinical Trial). 24-Hour IOP-Lowering Effect of the Wheel (On-Road) Performance in Patients ASIA-Association for Research in Vision and Glaucoma Patients before and after Cataract and Tolerability of Intravitreal Administration PI: Jeffrey L. Goldberg, M.D., Ph.D. 0.01% Bimatoprost. with Glaucoma and Healthy Controls. The Longitudinal Study of the Ocular Ophthalmology (ARVO) “The Rate of Structural Surgery. PI: Robert N. Weinreb, M.D. of VEGF Trap-Eye (Intravitreal Aflibercept Change in Glaucoma”, Delhi, India, PI: John H.K. Liu, Ph.D. PI: Felipe Medeiros, M.D., Ph.D. Injection [IAI]) in Patients with Macular Edema Complications of AIDS Renewal. Molecular Genetic Approach to Inherited Eye PI: William R. Freeman, M.D. October 28-30, 2013 24-Hour Intraocular Pressure (IOP) Patterns Secondary to Branch Retinal Vein Occlusion. Diseases. Co-I: Jeffrey L. Goldberg, M.D., Ph.D. A Randomized, Single-Center, Open-Label, Comparison of Measurements of Intraocular of Glaucoma Patients before and after PI: William R. Freeman, M.D. Crossover Study Comparing the Efficacy Pressure Pre and Post Topical Ocular Retina Patient Outcomes Registry Selective Laser Trabeculoplasty (SLT). Genetics of Ophthalmic Disease. of BOL-303259-X 0.024% (Latanoprostene Hypotensive Treatment in Glaucoma Patients and Prospective - Chart Review. KANG ZHANG, M.D., Ph.D. PI: Robert N. Weinreb, M.D. A Double-Masked, Randomized, Active- “Genetics of Retinal Diseases”, Department of PI: Jeffrey L. Goldberg, M.D., Ph.D. Bunod) Ophthalmic Solution with Timolol Using the Ocular Response Analyzer (ORA), Controlled, Phase III Study of the Efficacy, PI: William R. Freeman, M.D. Maleate Ophthalmic Solution 0.5% in Subjects Dynamic Contour Tonometry (DCT) and Human Genetics, Baylor College of Medicine, Evaluation of Visual and Task Performance in Safety and Tolerability of Intravitreal Retinal Cell Culture: Survival and with Open-Angle Glaucoma or Ocular Goldmann Applanation Tonometry (GAT). Study Evaluating Genotypes While Houston, TX, February 2013. Patients with Glaucoma, Suspected of Having Administration of VEGF. Regeneration (Prospective Clinical Trial). Hypertension – CONSTELLATION Study. PI: Felipe Medeiros, M.D., Ph.D. Using Lucentis 2 (SEAGUL). Glaucoma and Healthy Controls. PI: Robert N. PI: William R. Freeman, M.D. PI: Jeffrey L. Goldberg, M.D., Ph.D. PI: J. Rigby Slight, M.D., John H.K. Liu, Ph.D. PI: Kang Zhang, M.D., Ph.D. “Stem Cell Therapy for Retinal Diseases”, Weinreb, M.D. Angiogenesis, Exudation and Degeneration, The Effects of the Water Drinking Test on A Phase II, Multicenter Randomized, Corneal Endothelial Dysfunction: Evaluation of Bimatoprost 0.01% and Intraocular Pressure of Glaucoma Patients Genetic Assessment of Early to Late Bascom Palmer Eye Institute, Miami, FL, Clinical Studies of Swept-Source OCT. Double-Masked, Placebo-Controlled, Retrospective Review – Chart Review. Bimatoprost 0.03% in Patients with Undergoing 24-Hour Continuous Monitoring Macular Degeneration Study 2 (GALLEY). February 2013. PI: Robert N. Weinreb, M.D. Parallel-Group Study to Investigate the Safety, PI: Jeffrey L. Goldberg, M.D., Ph.D. Glaucoma or Ocular Hypertension. with the SENSIMED Triggerfish®. Tolerability, Efficacy, Pharmacokinetics and PI: Kang Zhang, M.D., Ph.D. PI: Felipe Medeiros, M.D., Ph.D. PI: Felipe Medeiros, M.D., Ph.D. “Stem Cell Therapy in the Eye”, Annual Pupil-Based Perimetry. Pharmacodynamics of GSK933776 with Treatment of Diabetic Retinopathy – Genetic Assessment of Early to Late Meeting of Chinese Retina Society, China, PI: Robert N. Weinreb, M.D. GA and AMD. PI: William R. Freeman, M.D. March 2013. Chart Review. A Randomized, Multicenter, Double-Masked, Evaluation of Visual and Task Performance Macular Degeneration Study 2 (GALLEY 2). PI: Jeffrey L. Goldberg, M.D., Ph.D. Parallel-Group Study Comparing the Safety in Patients with Glaucoma, Suspected of PI: Kang Zhang, M.D., Ph.D. An Age Stratified Data Collection Study in A Multicenter, Patient-Masked, Safety and Efficacy of BOL-303259-X 0.024% Having Glaucoma and Healthy Controls. “Restoration of Vision”, The Association for Adult Males and Females, Ages 18 and above Extension Study to Evaluate the Steroids and Laser Trabeculoplasty (SALT) Trial: (Latanoprostene Bunod) Ophthalmic Solution PI: Felipe Medeiros, M.D., Ph.D. Clinical Assessment of Age-Related Macular Research in Vision and Ophthalmology (ARVO), to Establish a Normative Database Using Biodegeneration of the Brimonidine Tartrate Effect of Anti-Inflammatory Treatment on the with Timolol Maleate Ophthalmic Solution Degeneration Patients after Early Diagnosis Invited Symposium, Seattle, WA, May 2013. the 3-D Optical Coherence Tomography 3-D Posterior Segment Drug Delivery System. Efficacy of SLT (Prospective Clinical Trial). 0.5% in Subjects with Open-Angle Glaucoma Retinal and Peripapillary Blood Flow and Treatment with Ranibizumab (COMPASS). Oct - 1000 Mark II. PI: Robert N. Weinreb, M.D. PI: William R. Freeman, M.D. PI: Jeffrey L. Goldberg, M.D., Ph.D. or Ocular Hypertension – Lunar Study. Assessment before and after Therapeutic PI: Kang Zhang, M.D., Ph.D. PI: Felipe Medeiros, M.D., Ph.D. Intervention in Glaucoma Using the Retinal 60 61 Prospective Case Crossover Study to Assess OPHTHALMOLOGIC PLASTIC AND Whether PDE5 Inhibitor Exposure in Men with Erectile Dysfunction Increases the Risk RECONSTRUCTIVE SURGERY for the Development of Non-Arteritic Anterior Loteprednol Etabonate Ophthalmic Ischemic Optic Neuropathy (NAION). Ointment vs. Soothe Night Time Ointment PI: Kang Zhang, M.D., Ph.D. for Inflammation. PI: Bobby S. Korn, M.D., Ph.D.

SHILEY EYE CENTER A Phase III, Double-Masked, Multicenter, Randomized, Active Treatment – Controlled Study of the Efficacy and Safety of 0.5 mg and 2.0 mg Ranibizumab Administered AWARDED PRESTIGIOUS Monthly or on an As-Needed Basis (PRN) in Patients with Subfoveal Neovascular Age-Related Macular Degeneration. PI: Kang Zhang, M.D., Ph.D.

Ranibizumab (Lucentis) for Treating NIH CORE GRANT Submacular Vascularized Ped. PI: Kang Zhang, M.D., Ph.D. n July 2012, $500,000 in annual funding was secured from the National SEVEN Year Observational Update of Eye Institute (NEI) for the “P30- Center Core Grant for Vision Research”. Macular Degeneration. Under the direction of the Principal Investigator and Director of the PI: Kang Zhang, M.D., Ph.D. Center Core Grant, Linda Zangwill, Ph.D., this grant provides shared resources to enhance and accelerate the productivity of the vision Seven Year Observational Update of Macular research community at UC San Diego (UCSD). It will leverage the Degeneration Patients Post Marina/Anchor expertise of the 20 National Eye Institute funded UCSD investigators and Horizon Trials (Seven UP Study). to advance discoveries from the 26 NIH funded major studies PI: Kang Zhang, M.D., Ph.D. I (known as a R01 grant).

PEDIATRIC OPHTHALMOLOGY The core grant also facilitates and enhances multidisciplinary collaboration among UCSD vision researchers and provides services that are unavailable Retinopathy of Prematurity Education or too expensive for individual investigators. Moreover, this core grant to Families of Neonates. brings together faculty from other UCSD departments including Pediatrics, PI: Shira L. Robbins, M.D. Pharmacology, UCSD’s Center for Computational Sciences, Mathematics, Engineering, Neurosciences, Pathology, Computer Science and Mathematics, Visual Function in Preterm Infants with as well as from the California Institute of Telecommunications and Information Regressed Retinopathy of Prematurity. Technology (CALIT2). PI: Shira L. Robbins, M.D. Important new resources and services are provided in four distinct Vision Screening of Pre-Schoolers substantive areas: 1) Vision Biostatistics, 2) Animal Structure and Function, in the San Diego Community. 3) Computational Ophthalmology, 4) Tissue Processing and Confocal Consultant: Shira L. Robbins, M.D. Microscopy. Module Directors include Felipe Medeiros, M.D., Ph.D., Dirk-Uwe Bartsch, Ph.D., Kang Zhang, M.D., Ph.D., William Freeman, M.D., LIngyun Chen, NEURO-OPHTHALMOLOGY M.D., Linda Zangwill, Ph.D. and Sonia Jain, Ph.D. imaging and a trained technician with experience in handling these devices. The Tissue Processing and Confocal Microscopy Module provides essential Functional-Structural Correlations in Eyes The Vision Biostatistics Module provides integrated statistical services to Dedicated imaging instruments are too expensive for a single investigator. tissue processing and microscopy resources with custom software tailored for with Non-Glaucomatous Optic Neuropathies. vision researchers. The biostatistician, familiar with the statistical issues The sharing of this resource offers synergy and saves costs. vision research to accelerate discoveries with the objective of preventing PI: Peter J. Savino, M.D. related to the analysis of vision research data will ensure quicker and the blinding consequences of glaucoma and various retinal diseases. more efficient analyses that will greatly enhance the productivity of The Computational Ophthalmology Module supports computationally intensive the investigators. analysis of structural imaging and functional tests used in animal and human Through the resources provided in this NIH Core Grant for Vision Research, vision research studies. These state-of-the-art computational and visualization new and established scientists at UCSD will take their internationally The Animal Structure and Function Module provides two key resources to resources with software tailored for vision research will support and thus recognized vision research program to the next level of innovation the vision research community – centralized animal structure and function accelerate discoveries in various vision research areas. and distinction. 62 63 GRANTS

COMPREHENSIVE OPHTHALMOLOGY Mitochondrial Dysfunction in Kruppel-like Transcription Factors in Restore Normal Function to Diseased African Descent and Glaucoma Age-Related Eye Disease Study II (AREDS II) Generation of IPS Lines for PEDIATRIC OPHTHALMOLOGY AND Glaucomatous Optic Neuropathy Retinal Ganglion Cell Regeneration Visual Circuits in Blinding Disorders Evaluation Study (ADAGES) Henry A. Ferreyra, M.D. Blinding Eye Diseases Cataract Surgical Education Grant Robert N. Weinreb, M.D. (Co-Investigator) Jeffrey L. Goldberg, M.D., Ph.D. Andrew Huberman, Ph.D. Linda Zangwill, Ph.D. EMMES Corporation/NIH/NEI, 04/12/07-12/31/12 Kang Zhang, M.D., Ph.D. EYE ALIGNMENT DISORDERS Jeffrey Lee, M.D. Alcon, 2013 NIH/NEI, 12/01/07-08/31/18 NIH/NEI, 08/01/10-06/30/14 Knights Templar Eye Foundation, 2012-2013 NIH/NEI, 09/01/09-08/31/12 (NCE) California Institute for Regenerative Medicine, Amblyopia Treatment Study Crystalline Antiproliferative Drugs 08/01/13-07/30/15 Shira L. Robbins, M.D. CORNEA & REFRACTIVE SURGERY Short-Term Estimation of Long-Term Triazine Compounds to Promote Development of Retinofugal Parallel Pathways African Descent and Glaucoma Evaluation for Intraocular Diseases Jaeb Center for Health Research/NIH/NEI, Intraocular Pressure Reduction Regeneration in Optic Neuropathies Andrew Huberman, Ph.D. Study (ADAGES) II: Glaucoma Progression William R. Freeman, M.D. 05/01/04-12/31/13 A Genome Wide Association Study of Robert N. Weinreb, M.D. (Co-Investigator) Jeffrey L. Goldberg, M.D., Ph.D. NIH/NEI, 02/01/12-01/31/17 Linda Zangwill, Ph.D. NIH/NEI, 09/30/08-07/31/12 OPHTHALMOLOGIC PLASTIC AND Fuchs Endothelial Corneal Dystrophy NIH/NEI, 07/01/08-06/30/14 NIH/OD, 06/01/11-05/31/13 NIH/NEI, 02/01/10-01/31/15 Natalie Afshari, M.D. RECONSTRUCTIVE SURGERY Genetic Dissection of Visual Studies of Retinopathy NIH/Center for Inherited The Development of a Patient Reported African Descent and Glaucoma Evaluation Functionalized Magnetic Nanoparticles Perception in Mammals Diagnostic Innovations in Glaucoma: of Aids in the HARRT Era Disease Research (CIDR) Outcome Questionnaire for Symptomatic Study II: Glaucoma Progression as a Therapeutic Tool to Improve Andrew Huberman, Ph.D. Structural Assessment William R. Freeman, M.D. Exophthalmos Associated Thyroid Eye Disease Robert N. Weinreb, M.D. (Co-Investigator) Axon Regeneration after Stroke The Whitehall Foundation, 2011-2012 Linda Zangwill, Ph.D. NIH/NEI, 04/01/10-03/31/14 Integrative Genetic Analyses in Fuchs Don O. Kikkawa, M.D. NIH/NEI, 02/01/10-01/31/15 Jeffrey L. Goldberg, M.D., Ph.D. NIH/NEI, 05/01/11-04/30/16 Endothelial Cornea Dystrophy Lithera, 09/23/10-09/30/12 James and Esther King Foundation, Trans-Synaptic Circuits for Define Novel Genes for Diabetic Natalie Afshari, M.D. New Techniques for Measuring Volumetric 11/01/11-10/30/12 Processing Directional Motion Center Core Grant for Vision Research Microvascular Complications NIH/NEI, 03/01/13-02/29/16 Loteprednol Etabonate Ophthalmic Ointment Structural Changes in Glaucoma Andrew Huberman, Ph.D. Linda Zangwill, Ph.D. Kang Zhang, M.D., Ph.D. vs. Soothe Night Time Ointment in the Robert N. Weinreb, M.D. (Co-Investigator) Signaling Scaffolds in Stroke The McKnight Endowment for Neuroscience, NIH/NEI, 07/01/12-06/30/17 Burroughs Welcome Fund Clinical Scientist Treatment of Inflammation Following NIH/NEI, 01/01/11-12/31/13 Jeffrey L. Goldberg, M.D., Ph.D. 2013-2015 Award in Translational Research, GLAUCOMA Eyelid Surgery NIH/NEI, 12/01/11-11/30/15 07/01/08-06/30/13 Bobby S. Korn, M.D., Ph.D. Research to Prevent Blindness Diagnostic Innovations in Glaucoma Study: Research on Retinal Ganglion Cells RETINA Unrestricted Grant Bausch and Lomb Pharmaceuticals, Functional Impairment Catalyst for a Cure: Biomarker Initiative Andrew Huberman, Ph.D. Molecular Basis of Hereditary Retinal Genetics and Functional Studies of Robert N. Weinreb, M.D. 02/01/12-07/01/14 Robert N. Weinreb, M.D. (Co-Investigator) Jeffrey L. Goldberg, M.D., Ph.D., Pew Charitable Trusts, 2013-2017 Degenerations Age-Related Macular Degeneration Research to Prevent Blindness Inc., NIH/NEI, 09/01/11-08/31/16 Andrew Huberman, Ph.D. Radha Ayyagari, Ph.D. Kang Zhang, M.D., Ph.D. 01/01/11-12/31/12 (NCE) Glaucoma Research Foundation, Mitochondrial Dysfunction in NIH/NEI, 09/01/11-08/31/15 NIH/NEI, 09/30/08 - 08/30/14 PATHOLOGY Predicting and Detecting Glaucomatous 02/01/12-01/31/15 Glaucomatous Optic Neuropathy Sirtuins in Glaucomatous Optic Neuropathy Endoplasmic Reticulum Stress in Progression Using Patterns Recognition Won-Kyu (Daniel) Ju, Ph.D. Mechanistic-Based Non-Invasive Assessment ELOVL4 and Retinal Disease Robert N. Weinreb, M.D. Retinal Degeneration Robert N. Weinreb, M.D. (Co-Investigator) Enhancing Optic Nerve NIH/NEI, 09/01/09-08/31/13 of Retinal Damage in HAART Era Kang Zhang, M.D., Ph.D. NIH/NEI, 01/01/11-12/31/13 Jonathan H. Lin, M.D., Ph.D. NIH/NEI, 02/01/12-01/31/16 Regeneration after Trauma Dirk-Uwe Bartsch, Ph.D. NIH/NEI, 11/01/08-04/30/13 (NCE) NIH/NEI, 09/01/10-05/31/15 Jeffrey L. Goldberg, M.D., Ph.D. Mitochondrial Dysfunction in NIH/NEI, 09/30/11-01/31/16 ADAGES III: Contribution of Genotype to Predicting and Detecting Glaucomatous DOD, 09/01/12-08/31/16 Glaucomatous Optic Neuropathy Regeneration of Retinal Neurons by Chemically Glaucoma Phenotype in African Americans Stem Cell-Derived Retinal Pigment Epithelium Progression Using Pattern Recognition Won-Kyu (Daniel) Ju, Ph.D. Porous Silicon Particles Ocular Safety and Induced Reprogramming of Muller Glia Robert N. Weinreb, M.D. to Treat Age-Related Macular Degeneration Christopher Bowd, Ph.D. Cell Therapy for Retinal Ganglion NIH/NEI, 09/01/13-08/31/18 Ocular Pharmacokinetics of Avastin Loaded Kang Zhang, M.D., Ph.D. NIH/NEI, 07/01/13-06/30/18 Jonathan H. Lin, M.D., Ph.D. NIH/NEI, 02/01/12-01/31/16 Cell Loss in Glaucoma Delivery System NIH/NEI, 09/30/10-09/29/15 BrightFocus Macular Degeneration Research Jeffrey L. Goldberg, M.D., Ph.D. Fluid Distribution before, Lingyun Cheng, M.D., Ph.D. Diagnostic Innovations in Glaucoma Study: Foundation Grant, 07/01/13-06/30/15 Retinal Scaffolds: Synaptic and Stem BrightFocus Foundation, 07/01/13-06/30/15 during and after Prolonged Space Flight Spinnaker Biosciences Inc., 09/01/11-08/31/16 Research to Prevent Blindness Senior Structural Assessment Cell Integration John H.K. Liu, Ph.D. Scientific Investigator Award Robert N. Weinreb, M.D. (Co-Investigator) Ocular Biomarkers for Alzheimer’s Jeffrey L. Goldberg, M.D., Ph.D. Timing the Treatment of Optic Nerve Injury Porous Silicon Particles for Sustained Kang Zhang, M.D., Ph.D. NIH/NEI, 04/01/95-04/30/16 Disease Amyloid NIH/NEI, 10/01/09-09/30/12 Jeffrey L. Goldberg, M.D., Ph.D. NASA Johnson Space Center, Intravitreal Drug Delivery Research to Prevent Blindness, 01/01/11-12/31/12 Jonathan H. Lin, M.D., Ph.D. DOD, 09/21/13-09/20/15 08/01/12-07/31/15 Lingyun Cheng, M.D., Ph.D. African Descent and Glaucoma Adlyfe, Inc., 05/01/11-09/01/13 Electrospun Scaffolds for 3-D NIH/NEI, 09/01/11-08/31/16 Regulation of the Hippo Pathway and its Role Evaluation Study Retinal Tissue Engineering Molecular Determinants of Synaptic Target Diagnostic Innovations in Glaucoma Study: in Uveal Melanoma Robert N. Weinreb, M.D. (Co-Investigator) Jeffrey L. Goldberg, M.D., Ph.D. Choice in the Developing Visual System Functional Impairment Testing and Evaluation of a Retinal Prosthesis Kang Zhang, M.D., Ph.D. NIH/NEI, 09/30/02-08/31/13 Interdisciplinary Research Development Andrew Huberman, Ph.D. Felipe A. Medeiros, M.D., Ph.D. Lingyun Cheng, M.D., Ph.D. NIH/NEI, 09/01/12-08/31/17 Initiative (UM), 07/01/10-08/31/12 The E. Matilda Zeigler Foundation NIH/NEI, 09/01/11-08/31/16 Nanovision Biosciences Inc., 07/30/12-07/29/13 64 for the Blind, 2010-2013 65 SUPPORTING THE DEPARTMENT OF OPHTHALMOLOGY

Outright Gifts Planned Gifts Matching Gifts Immediate Impact Your Vision for Tomorrow Double or Triple your Gift Outright gifts of all sizes made with Please consider a charitable Many employers offer a matching cash, credit card, savings bonds, bequest in your will, which benefits gift program to their employees marketable securities or property the future and directly supports meaning that your donations are provide immediate impact to our the Department of Ophthalmology worth even more. All you need is faculty and facility. while saving your family estate a Matching Gift Form from your For almost 30 years, tax dollars. We would be pleased employer. the philanthropic Annual Gifts to provide you, your attorney and your accountant or tax advisor, Circle of Sight Endowments support from generous with specific bequest language for Gifts in Perpetuity individuals, foundations Founded in 1996, the Circle of inclusion in your will or trust. Sight is the Shiley Eye Center’s and corporations has A gift of endowment demonstrates recognition program that your long-term commitment to the provided the Department acknowledges donors who make Tribute Gifts Department of Ophthalmology since of Ophthalmology with annual gifts of $250 or more to Acknowledge Someone Special the fund is maintained in perpetuity. support the greatest needs of the Contributions can be made in valuable resources for Your gift can support programs, Department. Several times a year, memory, honor or celebration of lectures, awards, fellowships and patient care, research, the Shiley Eye Center’s Circle of a loved one or to commemorate Chairs. An endowment serves as an education and community Sight members are invited to attend a special occasion. Gifts can be enduring legacy since it often bears Vision Research Lectures and made to honor a special physician, the name of a donor or loved one. service. The state of receptions where members get to for example, who has played a California provides less personally know our faculty. The significant role in your eye health. than 4% of our budget members are also ambassadors for Such a gift creates a legacy and the Shiley Eye Center within the memorializes the person by and therefore, we must San Diego community. The Circle providing direct support to the rely on private gifts. As a of Sight group is the backbone of Department. friend of the Department many of our successful initiatives. of Ophthalmology, there are several giving options

for those who wish to Every donation makes an impact on our patients, faculty and staff, as well as the For further information, contribute to our field of Ophthalmology. We cherish the partnership that we have developed with please contact: those generous members of the community who invest in us. There are also naming tradition of excellence. Karen Anisko Ryan opportunities for gifts including: endowed chairs, laboratories, specialized ophthalmic Phone: 858-534-8017 clinics and research initiatives. We would welcome the opportunity to have a confidential Email: [email protected] GIVING OPPORTUNITIES conversation with you, so we clearly understand how you want your gift to be used.

66 67 see Dr. Kikkawa and over time has developed a special relationship with his family as well. Trude believes, “Dr. Don Kikkawa is and always has been the perfect example of a true physician who makes a difference. He is not only equipped with an extraordinary pair of hands and eyes which bring healing for the most complicated and rare eye conditions. He has been my idol from the moment I met him. I soon recognized him also as a model husband and father.”

“Trude is an extraordinary person. Her grace, beauty and generosity are unparalleled. I have been extremely blessed to be her friend and am so touched and grateful for her kindness”, said Dr. Kikkawa.

The Shiley Eye Center’s Circle of Sight membership group and Dr. Kikkawa honored Trude with a special lecture and reception on March 13, 2013 to celebrate her 103rd birthday. Dr. Kikkawa’s lecture, entitled “Aging Gracefully” was presented to a standing room only audience. “Trude Hollander, M.D. is truly a stunning example s a retired physician, Trude Kahn her medical degree in Bonn and was one of of how to age gracefully and elegantly,” Hollander, M.D. understands the four women to graduate in a class of 120. Dr. says Dr. Kikkawa. importance of meticulous attention Hollander left Germany before World War II to to detail. She wanted to ensure complete her internship at Mount Zion Hospital in At UC San Diego, endowed chairs honor that her assets would be utilized in San Francisco. She then moved to Massachusetts exceptional faculty members for their contributions a meaningful way after her passing. and became board certified in gynecology. to academia and support their current work. They Dr. Hollander decided to generously She practiced in Springfield where she met her are also essential for attracting and retaining star Amake arrangements in her estate plan to benefit husband Alfred, a prominent dermatologist. Dr. faculty to the department. The Department of the UC San Diego Department of Ophthalmology Hollander had a successful career for 45 years Ophthalmology at the Shiley Eye Center presently and Shiley Eye Center by funding the Dr. Trude before retiring with her husband to San Diego in has five endowed chairs and with Dr. Hollander’s K. Hollander Endowed Chair in the Division of 1979. Her beloved Alfred passed away in 1987. gift, the future is promising as ever. If you are Ophthalmic Plastic and Reconstructive Surgery. Trude stays active and vibrant by having many interested in making an estate gift, please contact friends, exercising daily, traveling, reading, doing Karen Anisko Ryan at 858-534-8017 or Dr. Weinreb stated, “We appreciate Dr. Hollander’s crossword puzzles and attending the San Diego [email protected]. generosity for choosing the UC San Diego Shiley Symphony among other social events Eye Center to leave her lasting legacy towards and concerts. (above) Dr. Don Kikkawa and his children Claire, our future growth, innovation and success”. Jason and Alina with Dr. Trude Hollander Trude first came to know Don O. Kikkawa, M.D. PHYSICIAN THINKS OF SHILEY’S FUTURE Trude K. Hollander, M.D. was born in 1910 in as a patient at the UC San Diego Shiley Eye Offenburg, Germany and grew up along the Center in the late 1990’s and they have remained Rhine River and Black Forrest. She completed close friends ever since. She regularly comes to

68 69 RE-OPENING OF THE RATNER

new collaboration between the UC San Diego Shiley Eye hen a main pipeline underneath a building Director of the Ratner Children’s Eye Center and Anne Center, the UC San Diego Department of Bioengineering ruptures, it typically causes horrific damage Ratner Chair in Pediatric Ophthalmology, David B. Granet, and the Moxie Foundation of San Diego has created an to the interior of the building. Such was the M.D. brought the crowd to tears with his heartfelt reflection ophthalmic medical incubator program. This new program case on January 7, 2012 when that very thing on the memory and generosity of Anne Ratner as well as her was initiated by Florence Zahn, Director at the Moxie happened to the Anne F. and Abraham daughter Pauline Foster. “Few of us ever get to live a life that Foundation, through her longtime association with Robert Ratner Children’s Eye Center on a Saturday impacts others. Anne & Pauline as well as the entire family N. Weinreb, M.D., Director of the Shiley Eye Center and when the building was closed to patients have permanently altered the care of children once again. ChairA of the Department of Ophthalmology. andW no staff was present. On behalf of the children of San Diego, the Southwest, the entire US and the world I am honored to be the Florence and Dr. Weinreb were neighbors more than fifty years ago. The pressure from the water ripped through the foundation one who says Thank You!” They came back into contact when Florence and husband Irwin and within minutes, the entire building sustained 6-8 inches Zahn moved to San Diego. She became a patient at the Shiley Eye of muddy water. An on-duty security officer walking his rounds Preventing and treating vision loss and ocular problems Center after another neighbor directed her to where Dr. Weinreb was noticed water and mud oozing from underneath the doors. in children is the highest priority in the Division of Pediatric practicing and described his worldwide reputation. Florence observed The officer was able to get the water turned off but not Ophthalmology at the Anne F. and Abraham Ratner Children’s his outstanding clinical practice and cutting edge research and wanted before immense damage had taken its toll on the entire Eye Center which originally opened in 1995. The Ratner to further stimulate the scientific ventures at the Shiley Eye Center. interior infrastructure. The faculty and staff in the Division of physicians, David B. Granet, M.D. and Shira L. Robbins, Pediatric Ophthalmology were then moved into temporary M.D. treat over 5,000 adult and child patients annually. According to Dr. Weinreb, “This innovative program seeks to “dream, offices and clinical space at the Shiley Eye Center while design and develop” patient-centered medical devices to improve the pain-staking work to replace walls, flooring, carpeting, (right middle) Dr. David Granet, Pauline Foster and Dr. Shira Robbins the vision-related quality of life of patients with potentially blinding equipment, furniture and cabinets took place. eye diseases such as glaucoma, macular degeneration and diabetic (right bottom) Dr. Robert Weinreb, Chancellor Pradeep Khosla, Nine months later, the interior of the Ratner Eye Center retinopathy.” Paul Viviano, Pauline Foster, Dr. David Brenner, Dr. Stuart had been completely revitalized with new earth-tone color Brown and Dr. David Granet Initiating the program, Dr. Weinreb is working with Todd Coleman, schemes, hard-wood and cork flooring, modern furniture and LONGTIME FRIEND Ph.D., Associate Professor of Bioengineering at UC San Diego and updated equipment to enhance the family friendly atmosphere. graduate students to develop a miniature electronic device to enhance The Ratner has been operating with the new features while “We are honored that Pauline patient use of their prescription eye drops. Dr. Coleman stated, both the adult and children patients appreciating the changes. Foster is continuing her “The work we are doing is novel and has a high likelihood of improving patient treatments for several eye diseases.” On April 23, 2013, University of California, San Diego leaders family legacy in supporting ENCOURAGES and Ratner and Foster family and friends gathered to celebrate the renovations of the The Moxie Foundation is dedicated to enriching and empowering the reopening of the Ratner Children’s Eye Center. UC San individuals and communities by advancing educational achievement Diego Chancellor Pradeep Khosla and Director of the Shiley Ratner Children’s Eye Center” THE DEPARTMENT and entrepreneurial success, personal health and the environment. Eye Center Robert N. Weinreb, M.D. delivered opening remarks showing their gratitude to the family who The Department is grateful to the Zahns and the Moxie Foundation - Dr. Weinreb for their support. helped rebuild the center.

(left) Dr. Robert N. Weinreb, Dr. Todd P. Coleman, Florence and Irwin Zahn Dr. Weinreb stated, “We are honored that Pauline Foster is with graduate students Michael Bajema and Yun Soung Kim continuing her family legacy in supporting the renovations of the Ratner Children’s Eye Center”.

70 71 The Honor Roll for the Anonymous Alfred & Sharon Rappaport Foundation John Crabb, Ph.D. Miles & Patricia Bowler Gifts of $100 to $249 Department of Ophthalmology Steven & Sheri Altieri San Diego Lions Welfare Foundation Irma R. Keith Pearl M. Cutler Fred & Marjorie Caserio Diane O. Amatangelo Robert & Marjorie Beck Wilson & Jean Johnson Sexton Viktor Kerzhanovich Mary Yee DeBrunner Clint & Greta Coneway gratefully acknowledges Marilyn L. Ames Mr. & Mrs. Woody Carter Jeanne M. Sullivan The Honorable Milton L. & Oren Eisner Howard & Luella Davis Anonymous (11) donations from June 1, 2012 Lanna Cheng Jocelyn & Dick Vortmann Carolyn M. Lohr VISIONARY CIRCLE Nomi Feldman Caroline S. Demar Larry Bennett to August 31, 2013. Thank Nina & Robert Doede Stephen Wax & Laurie Price Burl Mackenzie Members of the Visionary Mrs. Esther Fischer Edith & Edward Drcar Jennifer Berend Marilyn and William* Field Macy’s The Gabriel Family Fund Irma J. Fischer you to all of the individuals, Circle are cumulative Mr. & Mrs. Thomas L. Black Kathleen & Steven M. Flynn / Gifts of $1,000 to $4,999 Helen E. Mildner Mona Ginsberg Carlos Flores foundations and corporations lifetime contributors of Ms. Carol L. Blink Bell Charitable Foundation The Honorable Jeffrey T. Miller Dr. & Mrs. Harold R. Hall Dr. Paul Frohna Sylvia A. Bode listed below. Richard Adams & Elizabeth Hansen one million dollars or Caroline & Daniel Hamlin Nancy & Roger Moore Steve Harden Louis M. Galper Dolores & James Boily Alcon more to the Department Paul & Rosemarie Kalemkiarian Allergan Dr. & Mrs. S. Mark Moran Joan & Howard Kontje Dr. & Mrs. Charles Gibb Betsy C. Bowne of Ophthalmology. We Miriam Neuhauser Charitable Trudy H. Anderson Lois M. Mulcahey Charles* & Rosemarie Kubes Howard & Carole Goldfeder The Stuart & Barbara L. Brody appreciate their generosity. Gifts of $500,000 & Above Remainder Trust Anonymous Fran Osborn & Tom Ryan Bernard Kulchin & Paula Taylor John J. & Mary A. Griffin Fund of the Jewish LM Newman Family Foundation Mary & Frank Pisciotta Lions Club of La Mesa Nancy E. & Victor Hugo Guerrero Hildyard Family Trust Farooq Azam Community Foundation Prevent Blindness Northern John & Diane Prewitt Family Tony & Mary Lovett Sook & Ron Hansen Dr. Trude K. Hollander Paul Blodgett & Birgitta Granberg Anonymous Dr. & Mrs R. O. Butcher California Foundation Asoka & Janine Mendis Frank H. Harding Dorothy R. Kerrigan Trust Charles & Inge Brown David J. Dunn Ben Cagle The Prudential Foundation Matching Pamela Bruder Valley & Phil Reilly Martin & Enid Gleich* Linda Milner Nick A. Johnston Federico Castro Gifts Program Arnold & Doris Roland Mr. & Mrs. B. James Polak Dave Kempston Gifts of $100,000 to $499,999 Dorothy R. Conte Jean Hahn Hardy Chung Yun Chang Qualcomm Foundation Prescott & Eunice* Crafts Jesse Russell Ricardo J. & Annie C. Rasines The La Jolla Villagers Zhizhong Chang & Pei Ren Zhuang Eleanor & John Barbey, Jr. Hildyard Family Trust Matthew Roth Anne & Walter Dempsey Mr. & Mrs. E. Robert Sawyer The Hal & Mary Sadler Family Anne & Thomas C. Lee Norma Childress David J. Dunn Dr. Trude K. Hollander Michael & Rosemary Roth Dorothy & Jacob Ettinger Todd D. Schafer Foundation (followed by the Mahmood F. Mafee, M.D. Nancy & Brian Cook Pauline Foster Joan and Irwin Jacobs Capt. & Mrs. Jerome R. Strayve, Mark T. Fay, M.D. Barbara & Sebastian Scripps San Diego Foundation icon) Iris P. Masotti Nancy Curren Research to Prevent Blindness Dorothy R. Kerrigan Trust USN (Ret.) Elsa & George Feher Catherine H. Setar Trust David & Ann Sakai Anthony & Eileen McKoy Mr. & Mrs. Ronald G. Damron Shiley Awards in Health Education Tatiana A. and Richard Kindell* Douglas Tan Connie Frank Mr. & Mrs. John J. So San Diego City Schools - Christa McReynolds John N. Datto and the Arts funded by Donald & Lansche Rudi Urlau Kathleen & Albert Fredman SPY Optic Inc. Community Service Association Betty L. Peabody Colette De Loeschnigg Darlene Shiley Arthur Murray & Carol-Faith James & Josephine Zolin Gerald Freedman Kathryn M. Starr R. J. & Joy Urich Kenneth D. Poli Bruce L. Deck Florence & Irwin Zahn James & Sally Zukerkorn The Friedman Family Fund of the Kay & Don Stone Murray Trust Jan Valdez Rita Bethea Rank Ms. Suzanne E. Demong Foundation Jewish Community Foundation Esao & Glenda Sumida Irvin Olson & Rita A. Olson Trust Thomas & Lucinda Vigne Justin Rockwell Charles Demoss Gifts of $50,000 to $99,999 Tully & Elise Friedman Sarah & Nessim Tiano Marc Paskin Charles Wegner LCDR John R. Savory, USN (Ret.) Daniel & Barbara Dickey Rita & Richard Atkinson Gifts of $5,000 to $9,999 Sion & Joyce Gannon Irving Tragen Anne F. Ratner* Christine & John Westwater Edwina Schatz Burton Duze Bob & Peg* Boemer Advanced Cell Technology, Inc. Dr. Roberto Felipe Garcia DeVere Vandervort Research to Prevent Blindness Eleanor L. Wetherill D. P. Schnorr Mr. Henry Ebert Giovanni Bucolo Family Foundation Alliance Healthcare Foundation Jane Goodwin, O.D. Maxine Vernec Ruth L. Schulman* Mrs. Christa L. Wissinger Georgina Serrano Romero Jeffrey & Cynthia Ebstein The Viterbi Family Fund of the Dr. Gloria Wolk Sharon E. Singer The California Endowment Anonymous (2) Salah M. Hassanein & Shiley Awards in Health Leonard Epstein/Empire Foods Wayne Green Jewish Community Foundation Betty Wong Rodney & Dolores Smith Rustom & Daneesh Appoo Zandra Rhodes Education and the Arts Ms. Ruth Fajarit-Davis Michel Mathieu Roger & Carolyn Williams Mr. & Mrs. Clinton R. Spangler Nick & Leslie Frazee Frances* & Leonard Hart funded by Donald* & Dr. Robert L. Fisher Irvin Olson & Rita A. Olson Trust Toby Wolf Gifts of $250 to $499 John Tiso Linda Fleming Jana Hess Hollywood Charity Horse Show Darlene Shiley Price Family Charitable Fund Warner C. & Debra E. Lusardi Marjorie C. & George W. Houck Dora Akuetteh, M.D. Carlos Tomaszewski Edward & Beryl Flom Michael & Rebecca Shiley Armi & Al Williams Foundation Margaret & Robert Hulter Gifts of $500 to $999 Anonymous (4) William A. & Susie M. Vidrih Marcia Foster Hazan Frances Hamilton White Nordstrom, Inc. Illumina, Inc. Mr. & Mrs. John Adey Marianne Barbano & Jef Karchin Margie V. Wilson, COMT Jamie & Bob Ginsberg Gifts of $10,000 to $49,999 The Halpin & Helen O’Reilly The Paul & Stacy Jacobs Family Anonymous Evelyn V. Bergmann Olive & Douglas Withall Cauleen & Michael Glass Mr. & Mrs. Leland R. Zimmerman 52 & Convoy Corp. Charitable Trust Fund of the Jewish Community Hal, Linda & Michelle Cordell * Deceased Sheldon & Lorrie Bernstein Phyllis & Morris Gold Lowell & April Blankfort Diane Golomb

72 73 W. E. Greer, III Louis & Ann Poulopoulos Carol V. Buuck Magnes Family Trust Jaye & Bill Hanley Mr. & Mrs. John Proakis Doris M. Campbell Marion J. Marcinkowski Research to Prevent Blindness is the world’s leading voluntary organization supporting eye George B. Henton Mary Jo Quinby Frances I. Castle Peggy Matthews The Department of research. RPB has provided grants totaling over $3 million to the Shiley Eye Center and the Harriet Jill Herndon Joan & Robert Rainbolt Mr. & Mrs. Paul E. Cincotta Nelda D. Mendoza Ophthalmology sadly Department of Ophthalmology since our inception. “We are extremely grateful to RPB for Jerome Hickmond Frank G. Reinhard Charles J. Coradino Theresa A. Miles acknowledges friends and their generous and ongoing support of our scientific discoveries and translational research,” Norma Hidalgo-Del Rio Angelo J. Sammartino Josephine Cree Jane & Gil Mombach key supporters who have said Robert N. Weinreb, M.D., Chairman and Distinguished Professor. Margareta & Jan-Erik Jansson Elsie Sautner Emma C. Crosas Rena Monge passed away during the Muriel Juster Ralph & Beverly Scarano Mr. & Mrs. Robert B. Daily Barbara Morgan past year. They remain Melanie Khouw Madelyn D. Sheets Lucien & Adeline Deslauriers Virginia Norwood in our thoughts. David L. Kier Frances T. Singleton Carol Duclos Mr. & Mrs. John Nunn Hisako Koike Harold F. Skelly, Sr. Frans Emmel Angela Piccillo Mr. William Field Mary Dianne Kubes Oleg & Courtney Sorokoumov John Evons Sue E. Presley Mr. C. H. Friedman Judith D. Langhoff Mrs. Carol Spangenberg David D. Farrelly, Jr. Maria & Daniel Reyes Mrs. Yvonne G. Gibb Barbara Lee Joan Ellen Spelman Maureen I. Fritzer Jose & Martha Rico Mrs. Enid P. Gleich Nancy Leitner Ivar Stakgold Jan Glenn Evelyn M. Robinson Mrs. Frances Hart Paul & Petrina Libby Jerry & Sally Stember Mr. & Mrs. Thomas E. Gnibus Doris Patinkin Rubin Mrs. Sarah Heyden Patricia & Albert Lubarsky Al & Joan Taddeo Paul Grossberg Walter S. Scheib, Jr. Mr. Charles J. Kubes Graham & Joanne MacHutchin Mr. & Mrs. Ernest M. Tassoni Frances J. Hamblin Sharon Schroeder Mr. Martin Lynn Ray Mallen Frank & Betsy Taylor Marcella E. Hamlin Harry & Linda Sheets Mr. Forrest N. Shumway Deborah & Fred Mandabach Rose H. Tran Louhelen E. Hassan Donna Shelton Dr. Faustina F. Solis Norman & Sivia Mann Victor* & Mihoko Vacquier Beatrice J. Hatrak Hrand I. Simonian Ms. Marjorie E. Van Dyke Leitha Marsolais Donatella Wachtel Mr. & Mrs. Harold J. Hebl Mrs. Patricia A. Smith Mr. Rex W. Warden Ms. Barbara B. Martin Harold O. Walker David N. Hennig Robert H. Solsbak Mr. A. Nash Williams William S. McConnor Dr. Lisa J. Wastila Estelle Herman Gilda & Fred Spiegl Col. Allen Wissinger, Bud & Nancy Meerchaum Robert E. Welk Nancy J. Holbrook & William D. Tania Spire USA, Ret. Bertha Melgoza, Ph.D. Mr.* & Mrs. Dana C. Wilson Gay, Jr. Barbara Jean Sundahl Patricia Merideth Toni Nickell Henry & Pauline Imus Anda Sztankay Barbara K. Meserve Albert Yatrofsky Richard A. Johnson United Way of San Diego County Sonja D. Metscher Reverend & Mrs. Fred Zacharias Stan & Jody Johnson Josina & Andy Van Die Mary Frances Miller Francisca Kandel Dr. Richard Wold Ted & Anabel Mintz Gifts up to $99 William & Sharon Kertzman Evelyn P. Woodlief Soz Mirza Naomi Aires Daniel & Michelle Klamm Gerald O. Woodlief Mrs. Gwyn M. Mitchell Anonymous (9) Jerome Klipp Bruce & Lisa Yarbro Muriel D. Mitchell Griselda Arellano Ron & Lillian Lang Arthur & Shirley Zeigler Ronald & Myrna Moe Lorna K. Baillif Tak-Ka Chung & Leung-Bun Lau Brian K. & Luisa D. Monson Gloria Van Dyke Lee Mrs. Concepcion A. Bandayrel * Deceased Jonathan, Suzanne & Andrew Morris Ismael A. Barajas, Jr. George & Nina Lewis Marguerite Morton Ronald L. Lilley This is a partial list. We have made every effort William H. Bayliff to be accurate in our listing and apologize if any Cheryl Nofield Jenny M. Biddle Amelia D. Lindlar mistake or omission has been made. Should you Lesley Overton Armindo Natal Lopes find an error or want to change your listing, Mr. & Mrs. Dwight E. Bishop please contact us at 858-534-4981. Janet Piskor Catherine Blackburn Carl & Claudia Lowenstein Ann E. Pitzer Nancy Bradsher Joe Lowry

74 75 NONPROFIT ORG. U.S. POSTAGE PAID SAN DIEGO, CA 9415 Campus Point Drive, MC 0946 PERMIT NO. 1909 La Jolla, CA 92093-0946

ADDRESS SERVICE REQUESTED