Sulfopin, a Selective Covalent Inhibitor of Pin1, Blocks Myc-Driven Tumor Initiation and Growth in Vivo
bioRxiv preprint doi: https://doi.org/10.1101/2020.03.20.998443; this version posted March 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo Christian Dubiella1,*, Benika J. Pinch2,3,4,*, Daniel Zaidman1, Theresa D. Manz2,3,5, Evon Poon6, ShuninG He7, Efrat Resnick1, Ellen M. LanGer8,9, Colin J. Daniel8,9, Hyuk-Soo Seo2, YinG Chen10, Scott B. Ficarro2,11,12,13, Yann Jamin14, Xiaolan Lian15,16,17, Shin Kibe15,16,17, ShinGo Kozono15,16,17, Kazuhiro Koikawa15,16,17, Zainab M. Doctor2,3, Behnam Nabet2,3, Christopher M. Browne2,3,18, Annan YanG2,19, Liat Stoler-Barak20, Richa B. Shah21,22, Nick E. VanGos2, Ezekiel A. Geffken2, Roni Oren23, Samuel Sidi21,22, Ziv Shulman20, Chu WanG10, Jarrod A. Marto2,11,12,13, Sirano Dhe- PaGanon2, Thomas Look7,24, Xiao Zhen Zhou15,16,17, Kun PinG Lu15,16,17, Rosalie C. Sears8,9,25, Louis Chesler6, Nathanael S. Gray2,3,#, Nir London1,# 1 Department of OrGanic Chemistry, The Weizmann Institute of Science, Rehovot, 7610001, Israel. 2 Department of Cancer BioloGy, Dana–Farber Cancer Institute, Boston, MA 02115, USA. 3 Department of BioloGical Chemistry and Molecular PharmacoloGy, Harvard Medical School, Boston, MA 02215, USA. 4 Department of Chemistry and Chemical BioloGy; Department of Chemical BioloGy, Harvard University, CambridGe, MA, 02138, USA.
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