biomedicines Review Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy Hsiang-Hao Chuang 1 , Yen-Yi Zhen 2, Yu-Chen Tsai 1, Cheng-Hao Chuang 1, Ming-Shyan Huang 3, Michael Hsiao 4,* and Chih-Jen Yang 1,5,6,* 1 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;
[email protected] (H.-H.C.);
[email protected] (Y.-C.T.);
[email protected] (C.-H.C.) 2 Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;
[email protected] 3 Department of Internal Medicine, E-Da Cancer Hospital, School of Medicine, I-Shou University, Kaohsiung 82445, Taiwan;
[email protected] 4 Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan 5 Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan 6 School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan * Correspondence:
[email protected] (M.H.);
[email protected] (C.-J.Y.); Tel.: +886-2-27871243 (M.H.); +886-7-3121101 (ext. 5651) (C.-J.Y.) Abstract: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomer- izes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting Pin1 is a potential therapeutic approach for various cancers by inhibiting cell proliferation, reducing metastasis, and maintaining Citation: Chuang, H.-H.; Zhen, Y.-Y.; genome stability.