DOCSLIB.ORG

COVER DESIGN Double Defense Uses

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
COVER DESIGN Double Defense Uses COVER DESIGN Double Defense Uses: Vectra® 3D for Dogs which has a 99.1% anti-feeding efficacy against mosquitoes 1 A heartworm preventive to kill heartworm larvae Dogs protected with Double Defense protocol had no adult heartworms1,2 Average Number Groups Number of Dogs with Heartworms of Adult Heartworms Per Dog Control + + + + + + + + 41 Vectra® 3D Only + + + 1.5 Milbemycin Only + + + + + + + + 17.1 DOUBLE DEFENSE Vectra® 3D and Milbemycin 0 Dogs 0 Learn why Vectra® 3D and Double Defense make sense for your practice at FightHeartwormNow.com DO NOT USE VECTRA® 3D ON CATS ©2018 Ceva Animal Health, LLC Vectra® and Vectra® 3D logo are registered trademarks of Ceva Animal Health, LLC Double Defense logo trademark is the property of Ceva Animal Health, LLC 1. McCall, J.W., Hodgkins, E., Varloud, M., Mansour, A., DiCosty, U., McCall, S., Carmichael, J., Carson, B., & Carter, J. (2016, August). Blocking of the transmission of Dirofilaria immitis L3 (JYD-34 ML resistant strain) from in- fected mosquitoes to dogs and prevention of infection in dogs treated topically with dinotefuran-permethrin-pyriproxyfen and orally with milbemycin oxime alone or in combination. In 61st Annual Meeting Proceedings: American Association of Veterinary Parasitologists- 61st Annual Meeting. San Antonio, TX. Abstract No. 21, 61. 2. McCall, J.W., Hodgkins, E., Varloud, M., Mansour, A., & DiCosty, U. (2015, July). Inhibition of the transmission of Dirofilaria immitis to mosquitoes by weekly exposure to microfilaremic dogs treated topically with dinotefuran-permethrin-pyriproxyfen to uninfected Aedes aegypti. In Annual Meeting Proceedings: American Association of Veterinary Parasitologists- 60th Annual Meeting. Boston, MA. Abstract No. 7, 59. 2 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 3 Ticks and fleas CAN turn my world UpsideDown Calling All Dogs, BIG and Small! Credelio is available in five convenient SKUs for dogs 4.4 to 100 pounds. Talk to your Elanco sales representative for more information and to place your order today. SKU Available for Indications Credelio kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American BIG Dogs dog tick), Ixodes scapularis (black-legged tick) and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater. 50.1-100 lbs! Important Safety Information The safe use of Credelio in breeding, pregnant or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures. The most frequently reported adverse reactions are weight loss, elevated blood urea nitrogen, excessive urination, and diarrhea. For product information, including complete safety information, see page 44.XX. Credelio, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. © 2019 Elanco or its affiliates. PM-US-19-0027 4 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com 12925_01_Credelio_900_Trade_Ad_PennVet_8.625x11.indd 1 2/1/19 4:02 PM 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 5 6 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com Please see prescribing Information on page 42. 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 7 8 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 9 46. 10 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com For your FREE digital copy of this handout, contact your Penn Vet Rep today! 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 11 12 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 13 14 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 15 16 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 17 LEPTOSPIROSIS IS A SMALL SIP AWAY Get full size protection in a half size vaccine ™ Nobivac EDGE Lepto4 is the FIRST and ONLY 0.5 ml Leptospirosis vaccine to help prevent mortality and urinary shedding for dogs of all sizes.1 18 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com 99% Reaction Free Out of 1583 Doses Given in CUTTING EDGE PROTECTION... Clinical Impressions Study1 Applied pressure NEW NOBIVAC 0.5 ml VACCINES Purified • Full protection, half the injection volume solution (50% less volume than standard vaccines) Filtration membrane Filtration membrane • Proven protection for dogs of all sizes Extraneous AFTER BEFORE proteins FILTRATION FILTRATION • VacciPure™ Technology supports vaccine safety VACCIPURE™ FILTRATION TECHNOLOGY1 NOBIVAC EDGE™ NOBIVAC EDGE™ NOBIVAC EDGE™ LEPTO4 DAPPv + L4 DAPPv • First 0.5 ml Leptospirosis • First 0.5 ml combo vaccine • First 0.5 ml combo vaccine vaccine shown to be effective to include parainfluenza to include parainfluenza against disease, mortality and protection1 protection1 1 shedding • First 0.5 ml Leptospirosis combo vaccine shown to be effective against disease, mortality and shedding1 TOTAL PROTEIN TESTING RESULTS FOR 0.5 ML VACCINES Average Total Protein (mg/dose) ™ NOBIVAC EDGE DAPPv+L4 5.0 mg/dose ULTRA™ DURAMUNE® DAP+4L 5.8 mg/dose Product is registered trademark of respective owner. mg 1 2 3 4 5 6 “While the decrease from 1 ml to 0.5 ml doesn’t sound like a lot, the ease of administration is notable. Not all vaccines are equal. The difference between injecting 0.5 ml and 1 ml when you have a puppy and 2-3 vaccines to give, you barely notice you’ve injected the volume. With the 0.5 ml vaccine, there was much less vocalization, and much less spilled vaccine. Thumbs-up from us for using NOBIVAC EDGE TM vaccines.” – Dr. Trathan, Oakdale Veterinary Group, Oakdale, CA Reference: 1. Data on file, Merck Animal Health. Copyright © 2018 Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck & Co., Inc. All rights reserved. US/NCA/1118/0005 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 19 Introducing Elanco Portfolio Rewards Valid on cumulative purchases Jan 1 - Mar 31, 2019 A Portfolio That Pays You Back Choosing the right products to meet your patients’ needs has never been more rewarding. Increasing your use of our best-selling products qualifies you for bigger savings. Purchase one or a mix of these key Elanco products to receive the following rebates: GROUP 1 PRODUCTS GROUP 2 PRODUCTS Cumulative Spend $5,000- $15,000- $20,000- $30,000- Any combination of products ≥$40,000 from either group $14,999 $19,999 $29,999 $39,999 Rebate Earned 1% 2% 3% SPOTLIGHT BONUS Purchase $2,500 of Credelio to receive a 1% additional rebate on all group 1 products! GROUP 1 PRODUCTS Total Rebate Earned with Spotlight Bonus 2% 3% 4% Rebate Earned 10% 15% 20% 25% 30% SPOTLIGHT Purchase $2,500 of ULTRA Duramune, ULTRA Fel-O-Vax, ULTRA Hybrid FVRCP, ULTRA Duramune BONUS Lyme and/or Bronchi-Shield ORAL to receive a 5% additional rebate on all group 2 products! GROUP 2 PRODUCTS Total Rebate Earned with Spotlight Bonus 15% 20% 25% 30% 35% Here’s how it works: • Purchase one product or mix and match multiple Elanco products in group 1 and group 2 • Rebates will be issued quarterly • Purchase specific products to unlock Spotlight Bonuses 20 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 21 22 | Penn Veterinary Supply | March-April 2019 1-800-233-0210 | www.pennvet.com 1-800-233-0210 | www.pennvet.com Penn Veterinary Supply | March-April 2019 | 23 FEATUREDPROMOTIONS PROMOTIONS VENDOR END DATE ITEMS PROMOTION Purchase Avagard antiseptic hand prep and get a free wall 3M 12/31/2019 Avagard bracket and foot pump or a wall bracket and hand pump. Purchase 20 tests, receive a free VUE, cPL Starter Kit, and Abaxis 3/31/2019 VetScan cPL Rapid Tests Andriod Mobile Device Buy 25 VetScan UA14 strips and get 50% off your VetScan UA 3/31/2019 VetScan UA Urine Analyzer analyzer. Andover Healthcare 4/30/2019 PetFlex Buy any 2 boxes of PetFlex and get one 6‐pack sample box. Adaptil and Feliway Pheromone Ceva 3/31/2019 Buy 3, get 1 free. Mix and match. Products 3/31/2019 Catego Buy 3 cartons, get 1 carton free. Mix and match. 3/31/2019 Clenz‐a‐dent & Breakables Products Buy 1, get 1 free. Mix and match. 3/31/2019 MilbeGuard Buy 1 carton of each size, get 1 carton of each size free. 3/31/2019 Vectra & Vectra 3D Buy 3 cartons, get 1 carton free. Mix and match. Fuzion, Hydrogen Peroxide, and Clorox Healthcare 3/31/2019 Buy 2, get 1 free. Kind for kind. Disinfecting Bio Stain & Odor Remover Datamars 4/30/2019 PetLink Slim Microchips Buy 50 microchips, get 10 microchips free. Dechra 3/31/2019 Carprofen Injection Buy 3, get 1 free. 3/31/2019 Carprofen Caplets Buy 4, get 1 free. Mix and match. Buy 4, get 1 free plus 1 free bottle of Carprovet Flavored Tablets 3/31/2019 Carprofen Chew Tabs 100mg. 3/31/2019 Carprovet Flavored Tabs Buy 3, get 1 free.
Load more

Recommended publications
  • WAAVP2019-Abstract-Book.Pdf
    27th Conference of the World Association for the Advancement of Veterinary Parasitology JULY 7 – 11, 2019 | MADISON, WI, USA Dedicated to the legacy of Professor Arlie C. Todd Sifting and Winnowing the Evidence in Veterinary Parasitology @WAAVP2019 @WAAVP_2019 Abstract Book Joint meeting with the 64th American Association of Veterinary Parasitologists Annual Meeting & the 63rd Annual Livestock Insect Workers Conference WAAVP2019 27th Conference of the World Association for the Advancements of Veterinary Parasitology 64th American Association of Veterinary Parasitologists Annual Meeting 1 63rd Annualwww.WAAVP2019.com Livestock Insect Workers Conference #WAAVP2019 Table of Contents Keynote Presentation 84-89 OA22 Molecular Tools II 89-92 OA23 Leishmania 4 Keynote Presentation Demystifying 92-97 OA24 Nematode Molecular Tools, One Health: Sifting and Winnowing Resistance II the Role of Veterinary Parasitology 97-101 OA25 IAFWP Symposium 101-104 OA26 Canine Helminths II 104-108 OA27 Epidemiology Plenary Lectures 108-111 OA28 Alternative Treatments for Parasites in Ruminants I 6-7 PL1.0 Evolving Approaches to Drug 111-113 OA29 Unusual Protozoa Discovery 114-116 OA30 IAFWP Symposium 8-9 PL2.0 Genes and Genomics in 116-118 OA31 Anthelmintic Resistance in Parasite Control Ruminants 10-11 PL3.0 Leishmaniasis, Leishvet and 119-122 OA32 Avian Parasites One Health 122-125 OA33 Equine Cyathostomes I 12-13 PL4.0 Veterinary Entomology: 125-128 OA34 Flies and Fly Control in Outbreak and Advancements Ruminants 128-131 OA35 Ruminant Trematodes I Oral Sessions
    [Show full text]
  • A Randomized, Controlled Field Study to Assess the Efficacy and Safety Of
    Karadzovska et al. Parasites & Vectors (2017) 10:528 DOI 10.1186/s13071-017-2469-x RESEARCH Open Access A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (Credelio™)in eliminating fleas in client-owned dogs in the USA Daniela Karadzovska1, Kimberly Chappell2, Shane Coble2, Martin Murphy3, Daniela Cavalleri3, Scott Wiseman4, Jason Drake2* and Steve Nanchen3 Spanish version: Please see Additional file 1 (https://doi.org/10.1186/s13071-017-2469-x) for the Spanish version of this article and Additional file 2 for the French translation of the Abstract. Abstract Background: Preclinical studies have shown that the novel isoxazoline, lotilaner (Credelio™, Elanco) administered orally to dogs, produces rapid flea and tick knockdown and sustained speed of kill for at least a month post- treatment with a wide safety margin. A field study was undertaken to validate pre-clinical results. Methods: Dogs were enrolled at 10 veterinary clinics across the United States. Qualifying households containing up to three dogs and one primary dog with at least 10 fleas were randomized 2:1 to receive lotilaner (Credelio™,Elanco)at the recommended minimum dose of 20 mg/kg, or afoxolaner (Nexgard®, Merial), administered per label, to give a minimum dose of 2.5 mg/kg. Treatments were dispensed on Days 0, 30 and 60 for administration by owners; all household dogs received the same treatment as the primary dog. Post-enrollment flea and tick counts were made on primary dogs on Days 30, 60 and 90, and all dogs were assessed for tablet palatability and safety.
    [Show full text]
  • Frontline Tri-Act®) Against Haemaphysalis Longicornis Tick Infestation in Dogs Wilfried Lebon1* Julian Liebenberg2 Nadège Perier3 Doug Carithers4 Fréderic Beugnet3
    Efficacy of a Single Spot-on Administration of Fipronil and Permethrin (Frontline Tri-act®) Against Haemaphysalis longicornis Tick Infestation in Dogs Wilfried Lebon1* Julian Liebenberg2 Nadège Perier3 Doug Carithers4 Fréderic Beugnet3 1Boehringer Ingelheim, Saint-Vulbas, France 2Clinvet, Universitas, Bloemfontein, South Africa 3Boehringer Ingelheim, Lyon, France 4Boehringer Ingelheim, Animal Health USA Inc., Duluth, USA *E-mail: [email protected] KEY WORDS: Haemaphysalis longicornis, formed at 24 hours post-infestations on Days fipronil, permethrin, Frontline Tri-Act, dog, 8, 15, 22, and 29, and ticks were removed efficacy. and counted at 48 hours post-treatment (on Day 2) and after each tick infestation on ABSTRACT Days 9, 16, 23, and 30. Acaricidal efficacies A blinded controlled laboratory study was for 24h thumb-counts were 100%, 98.8%, conducted to assess the acaricidal efficacy of 91.7%, and 84.4% on Days 8, 15, 22, and the fipronil/permethrin spot-on formulation 29, respectively. Efficacies of 98.1%, 100%, (Frontline Tri-Act®, Boehringer Ingelheim) 100%, 98.1%, and 94.7% were determined against Haemaphysalis longicornis ticks. based on removal counts performed on Days Fourteen healthy dogs were included in this 2, 9, 16, 23, and 30, respectively. There were study. Dogs in Group 1 served as untreated significant differences of the number of live controls while dogs in Group 2 were treated with Frontline Tri-Act on Day 0 at the ticks between treated and control group at minimum recommended dose of 0.1 mL/ each time-point (p <0.005). A single topical kg, corresponding to 6.76 mg/kg fipronil, administration of the combination of fipronil and 50.48 mg/kg permethrin.
    [Show full text]
  • (Credelio™) Against Haemaphysalis Longicornis Infestations of Dogs
    Otaki et al. Parasites & Vectors (2018) 11:448 https://doi.org/10.1186/s13071-018-3032-0 RESEARCH Open Access Laboratory evaluation of the efficacy of lotilaner (Credelio™) against Haemaphysalis longicornis infestations of dogs Hiroshi Otaki1, Junko Sonobe1, Martin Murphy2, Daniela Cavalleri2, Wolfgang Seewald2, Jason Drake3* and Steve Nanchen2 Abstract Background: Throughout Japan, Korea and China, Haemaphysalis longicornis ticks are vectors of Babesia gibsoni, which causes severe and progressive anemia in dogs. This study evaluated the efficacy of a single administration of lotilaner flavored chewable tablets (CredelioTM) against experimental canine H. longicornis infestations. Methods: Twenty-two healthy Beagles were ranked in descending order of counts of H. longicornis completed 48 h after challenge on Day -7. The 16 dogs with the highest live tick counts were blocked into pairs and within pairs randomized to either lotilaner-treatment at a minimum dose rate of 20 mg/kg or sham-treated controls. Treatment was administered within 30 ± 5 min following feeding on Day 0. Infestations with 50 unfed adult H. longicornis were completed on Days -2, 7, 14, 21, 28 and 35. Elizabethan collars were placed for 48 (± 2) h after each infestation and a T-shirt was placed on each dog to facilitate attachment. Ticks were counted in situ 12 and 24 h post-treatment and counted and removed after an additional 24 h (48 h after treatment) and 48 h after each post- treatment infestation. Dogs were sedated for tick challenges and counts. Live attached ticks on each dog were counted for efficacy assessments. Lotilaner was considered effective if the average tick attachment rate in the control group was at least 20%, if there was a statistically significant difference (P < 0.05) in mean tick counts between treated and control groups, and if the lotilaner-treated group had a calculated efficacy of at least 90%.
    [Show full text]
  • Lecture Overview Meet Kenny
    CVMA-SBCV Chapter Fall Conference and Trade Show Isoxazolines November 3rd 2019 Lecture overview ‣ Introduction ‣ Mechanism of action ‣ Disadvantage ‣ Advantages ‣ Extra-label use ‣ Implications for practice CONFIDENTIAL INFORMATION - MARS INC. 1 Meet Kenny https://www.canadianveterinarians.net/documents/wcv-summer-2019 CONFIDENTIAL INFORMATION - MARS INC. 2 Dr. Vincent Defalque Diplomate of the American College of Veterinary Dermatology North West Veterinary Dermatology Services CVMA-SBCV Chapter Fall Conference and Trade Show Isoxazolines November 3rd 2019 Meet Kenny ‣ 6 month-old intact male Australian Shepherd. ‣ Seen at North West Veterinary Dermatology Specialists in September 2015. ‣ Demodicosis lesions predominantly facial. ‣ Also had a severe secondary bacterial pyoderma caused by methicillin- resistant Staphylococcus pseudintermedius. ‣ Severe pruritus. Needed to wear an Elizabethan collar 24/7! ‣ Considering the age, but most importantly the breed of the patient (a well know ivermetin sensitive breed), I decided it was a great opportunity to treat my first case of canine demodicosis with oral fluralaner. CONFIDENTIAL INFORMATION - MARS INC. 3 Single dose of oral fluralaner before and after pictures Day 0 Day 44 CONFIDENTIAL INFORMATION - MARS INC. 4 Dr. Vincent Defalque Diplomate of the American College of Veterinary Dermatology North West Veterinary Dermatology Services CVMA-SBCV Chapter Fall Conference and Trade Show Isoxazolines November 3rd 2019 Introduction ‣ Flea and tick infestation is a major health problem in dogs and cats. ‣ Control presents an economic burden to pet owners. ‣ Recent advances in product technology have greatly expanded the available options for veterinarians and pet owners. ‣ Afoxolaner, fluralaner, lotilaner and sarolaner are novel synthetic members of the isoxazoline class of parasiticides showing activity against insects and acarines, including fleas and ticks.
    [Show full text]
  • Distinct Molecular Targets for Macrocyclic Lactone and Isoxazoline Insecticides in the Human Louse
    bioRxiv preprint doi: https://doi.org/10.1101/2020.08.06.239400; this version posted August 6, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Journal: PLoS Pathogens 2 3 Full title: 4 Distinct molecular targets for macrocyclic lactone and isoxazoline insecticides in the 5 human louse: new prospects for the treatment of pediculosis 6 7 Short title: 8 Molecular targets of insecticides in the human louse 9 10 Nicolas Lamassiaude1, Berthine Toubate2, Cédric Neveu1, Pierre Charnet3, Catherine Dupuy2, 11 Françoise Debierre-Grockiego2, Isabelle Dimier-Poisson2,* and Claude L. Charvet1,* 12 13 1INRAE, Université de Tours, ISP, F-37380, Nouzilly, France 14 2Université de Tours, INRAE, ISP, F-37000, Tours, France 15 3Institut des Biomolécules Max Mousseron, UMR5247, CNRS, Université de Montpellier, 16 34095 Montpellier, France 17 18 Co-corresponding authors: 19 ⃰ [email protected] (CLC) ORCID iD: 0000-0002-0596-6598 20 Tel: +33 247427567 21 Institut national de recherche pour l’agriculture, l’alimentation et l’environnement 22 UMR1282 - Infectiologie et Santé Publique 23 Centre de Recherche Val de Loire 24 37380 Nouzilly, France 25 26 ⃰ [email protected] (IDP) ORCID iD: 0000-0001-8917-4493 27 Tel: +33 247367183 28 Université de Tours 29 UMR1282 - Infectiologie et Santé Publique 30 37000 Tours, France 31 32 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.08.06.239400; this version posted August 6, 2020.
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]
  • The Novel Isoxazoline Ectoparasiticide Lotilaner (Credelio™): a Non-Competitive Antagonist Specific to Invertebrates Γ-Aminob
    Rufener et al. Parasites & Vectors (2017) 10:530 DOI 10.1186/s13071-017-2470-4 RESEARCH Open Access The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ- aminobutyric acid-gated chloride channels (GABACls) Lucien Rufener1*, Vanessa Danelli1, Daniel Bertrand2 and Heinz Sager1 The online version of this article (https://doi.org/10.1186/s13071-017-2470-4) contains supplementary material, which is available to authorized users. Please see Additional file 2 for the French translation of the Abstract. Abstract Background: The isoxazolines are a novel class of parasiticides that are potent inhibitors of γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and, to a lesser extent, of inhibitory glutamate-gated chloride channels (GluCls). Lotilaner (Credelio™), a novel representative of this chemical class, is currently evaluated for its excellent ectoparasiticide properties. Methods: In this study, we investigated the molecular mode of action and pharmacology of lotilaner. We report the successful gene identification, cDNA cloning and functional expression in Xenopus oocytes of Drosohpila melanogaster (wild type and dieldrin/fipronil-resistant forms), Lepeophtheirus salmonis (an ectoparasite copepod crustacean of salmon), Rhipicephalus microplus and Canis lupus familiaris GABACls. Automated Xenopus oocyte two-electrode voltage clamp electrophysiology was used to assess GABACls functionality and to compare ion channel inhibition by lotilaner with that of established insecticides addressing GABACls as targets. Results: In these assays, we demonstrated that lotilaner is a potent non-competitive antagonist of insects (fly) GABACls. No cross-resistance with dieldrin or fipronil resistance mutations was detected, suggesting that lotilaner might bind to a site at least partly different from the one bound by known GABACl blockers.
    [Show full text]
  • No Slide Title
    The Fleas (Blood Suckers) Are Back… Are You Ready? Philip G. Koehler FPMA Endowed Professor of Urban Entomology Margie & Dempsey Sapp Endowed Professor of Structural Pest Control Department of Entomology University of Florida Gainesville, FL 32611 UF Entomology is #1 Entomology Department Rankings • 1 University of Florida, 100 score • 2 University of California, Riverside, 95.23 • 3 Cornell University, 91.95 • 4 Kansas State University, 91.29 • 5 North Carolina State University, 90.88 • 6 Michigan State University, 90.74 • 7 University of California, Davis, 89.88 • 8 University of Georgia, 88.98 • 9 Nanjing Agricultural University, China, 86.74 • 10 University of São Paulo in Brazil, 86.74 The Fleas are Back, You Filthy Cat!! Run! The Blood Suckers are Back! 7 Reasons to Not Have Cats 5. 4. 3. 6. 2. 1. 7. Ticks UGA Attacked by Fleas And Gators!! I know, Fleas are Back and the Animal Treatments No Longer Work Why are fleas important? Infestations on Pets Flea Bites on People Why are fleas important? The Perfect Solution for Fleas Before After Cat Flea Cat flea is the most important flea in the US It attacks both cats and dogs as well as many other animals skunks cats raccoons possums foxes coyotes How to Remove “Cat Fleas” “Cat Fleas” Attack Dogs even dumb dogs Cat Flea Life Cycle Flea control is based on biology • Eggs fall off host into carpet, on floor, or into lawn • One cat produced 10,000 eggs in 24 hours • Areas with pet access must be treated Eggs Flea feces Flea Laying Eggs Flea control is based on biology • Larvae hatch and
    [Show full text]
  • Technical Update
    Technical Update 1 NOVEMBERER 2017 Selected Recent Publications Pyrethroid resistance alters the blood-feeding behavior in Puerto Rican Aedes aegypti mosquitoes exposed to treated fabric. Agramonte NM, Bloomquist JR, Bernier UR. PLoS Negl Trop Dis. 2017 Sep 20 This paper might be of interest to some as it shows some dose-response curves for a Puerto Rican strain of Ae. Aegypti in response to topical toxicity of five insecticides (permethrin, etofenprox, deltamethrin, DDT, transfluthrin) was determined Behavioral differences in blood-feeding activity for pyrethroid-resistant and pyrethroid-susceptible strains of Ae. aegypti when exposed to pyrethroid-treated cloth were also explored. The American Journal of Tropical Medicine and Hygiene recently published a supplement titled: Evaluating the Impact of Malaria Control Interventions in sub-Saharan Africa Which includes thirteen articles focused on a variety of topics related to impact evaluation of malaria control efforts. The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito. PLoS Genet. 2017 Oct 4, Hammond et al Here the authors assess the potential for the emergence of resistance to a gene drive mechanism by allowing it to run for 25 generations and monitoring the frequency of the gene drive over time. They claim to be the first to document an example of selection for resistance to a synthetic gene drive. This raises questions about critical issues regarding design recommendations and considerations in order to mitigate possible resistance that could impact future gene drive applications. Relative performance of indoor vector control interventions in the Ifakara and the West African experimental huts.
    [Show full text]
  • Credelio, INN-Lotilaner
    16 February 2017 EMA/118228/2017 Veterinary Medicines Division Committee for Medicinal Products for Veterinary Use CVMP assessment report for Credelio (EMEA/V/C/004247/0000) International non-proprietary name: lotilaner Assessment report as adopted by the CVMP with all information of a commercially confidential nature deleted. 30 Churchill Place ● Canary Wharf ● London E14 5EU ● United Kingdom Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact An agency of the European Union © European Medicines Agency, 2017. Reproduction is authorised provided the source is acknowledged. Introduction ................................................................................................ 4 Scientific advice .......................................................................................................... 4 MUMS/limited market status ........................................................................................ 4 Part 1 - Administrative particulars .............................................................. 5 Detailed description of the pharmacovigilance system ..................................................... 5 Manufacturing authorisations and inspection status ......................................................... 5 Overall conclusions on administrative particulars ............................................................ 5 Part 2 - Quality ............................................................................................ 5 Composition
    [Show full text]
  • Poisons Standard February 2020
    POISONS STANDARD FEBRUARY 2020 I, Avi Rebera, as delegate of the Secretary to the Department of Health, make the following Poisons Standard. Dated 23 December 2019 Avi Rebera Assistant Secretary Regulatory Engagement and Planning Branch Health Products Regulation Group Department of Health Authorised Version F2020L00017 registered 10/01/2020 1. Name This instrument is the Poisons Standard February 2020. 2. New Poisons Standard This instrument consists of the Standard for the Uniform Scheduling of Medicines and Poisons No. 27 (the SUSMP 27), as set out in Schedule 2. 3. Commencement (1) Each provision of this instrument specified in column 1 of the table commences, or is taken to have commenced, in accordance with column 2 of the table. Any other statement in column 2 has effect according to its terms. Commencement information Column 1 Column 2 Column 3 Provisions Commencement Date/Details 1. The whole of this 1 February 2020. 1 February 2020 instrument Note: This table relates only to the provisions of this instrument as originally made. It will not be amended to deal with any later amendments of this instrument. (2) Any information in column 3 of the table is not part of this instrument. Information may be inserted in this column, or information in it may be edited, in any published version of this instrument. 4. Authority This instrument is made under paragraph 52D(2)(b) of the Therapeutic Goods Act 1989. 5. Repeals Each instrument that is specified in Schedule 1 to this instrument is repealed as set out in that Schedule. Authorised Version F2020L00017 registered 10/01/2020 Schedule 1—Repeals Note: See section 5.
    [Show full text]