bioRxiv preprint doi: https://doi.org/10.1101/2020.08.06.239400; this version posted August 6, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Journal: PLoS Pathogens 2 3 Full title: 4 Distinct molecular targets for macrocyclic lactone and isoxazoline insecticides in the 5 human louse: new prospects for the treatment of pediculosis 6 7 Short title: 8 Molecular targets of insecticides in the human louse 9 10 Nicolas Lamassiaude1, Berthine Toubate2, Cédric Neveu1, Pierre Charnet3, Catherine Dupuy2, 11 Françoise Debierre-Grockiego2, Isabelle Dimier-Poisson2,* and Claude L. Charvet1,* 12 13 1INRAE, Université de Tours, ISP, F-37380, Nouzilly, France 14 2Université de Tours, INRAE, ISP, F-37000, Tours, France 15 3Institut des Biomolécules Max Mousseron, UMR5247, CNRS, Université de Montpellier, 16 34095 Montpellier, France 17 18 Co-corresponding authors: 19 ⃰
[email protected] (CLC) ORCID iD: 0000-0002-0596-6598 20 Tel: +33 247427567 21 Institut national de recherche pour l’agriculture, l’alimentation et l’environnement 22 UMR1282 - Infectiologie et Santé Publique 23 Centre de Recherche Val de Loire 24 37380 Nouzilly, France 25 26 ⃰
[email protected] (IDP) ORCID iD: 0000-0001-8917-4493 27 Tel: +33 247367183 28 Université de Tours 29 UMR1282 - Infectiologie et Santé Publique 30 37000 Tours, France 31 32 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.08.06.239400; this version posted August 6, 2020.