DOCSLIB.ORG

Vol. 85 Wednesday, No. 63 April 1, 2020 Pages 18105–18412

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Vol. 85 Wednesday, No. 63 April 1, 2020 Pages 18105–18412 Vol. 85 Wednesday, No. 63 April 1, 2020 Pages 18105–18412 OFFICE OF THE FEDERAL REGISTER VerDate Sep 11 2014 20:47 Mar 31, 2020 Jkt 250001 PO 00000 Frm 00001 Fmt 4710 Sfmt 4710 E:\FR\FM\01APWS.LOC 01APWS jbell on DSKJLSW7X2PROD with FR_WS II Federal Register / Vol. 85, No. 63 / Wednesday, April 1, 2020 The FEDERAL REGISTER (ISSN 0097–6326) is published daily, SUBSCRIPTIONS AND COPIES Monday through Friday, except official holidays, by the Office PUBLIC of the Federal Register, National Archives and Records Administration, under the Federal Register Act (44 U.S.C. Ch. 15) Subscriptions: and the regulations of the Administrative Committee of the Federal Paper or fiche 202–512–1800 Register (1 CFR Ch. I). The Superintendent of Documents, U.S. Assistance with public subscriptions 202–512–1806 Government Publishing Office, is the exclusive distributor of the official edition. Periodicals postage is paid at Washington, DC. General online information 202–512–1530; 1–888–293–6498 Single copies/back copies: The FEDERAL REGISTER provides a uniform system for making available to the public regulations and legal notices issued by Paper or fiche 202–512–1800 Federal agencies. These include Presidential proclamations and Assistance with public single copies 1–866–512–1800 Executive Orders, Federal agency documents having general (Toll-Free) applicability and legal effect, documents required to be published FEDERAL AGENCIES by act of Congress, and other Federal agency documents of public Subscriptions: interest. Assistance with Federal agency subscriptions: Documents are on file for public inspection in the Office of the Federal Register the day before they are published, unless the Email [email protected] issuing agency requests earlier filing. For a list of documents Phone 202–741–6000 currently on file for public inspection, see www.federalregister.gov. The seal of the National Archives and Records Administration The Federal Register Printing Savings Act of 2017 (Pub. L. 115- authenticates the Federal Register as the official serial publication 120) placed restrictions on distribution of official printed copies established under the Federal Register Act. Under 44 U.S.C. 1507, of the daily Federal Register to members of Congress and Federal the contents of the Federal Register shall be judicially noticed. offices. Under this Act, the Director of the Government Publishing The Federal Register is published in paper and on 24x microfiche. Office may not provide printed copies of the daily Federal Register It is also available online at no charge at www.govinfo.gov, a unless a Member or other Federal office requests a specific issue service of the U.S. Government Publishing Office. or a subscription to the print edition. For more information on how to subscribe use the following website link: https:// The online edition of the Federal Register is issued under the www.gpo.gov/frsubs. authority of the Administrative Committee of the Federal Register as the official legal equivalent of the paper and microfiche editions (44 U.S.C. 4101 and 1 CFR 5.10). It is updated by 6:00 a.m. each day the Federal Register is published and includes both text and graphics from Volume 1, 1 (March 14, 1936) forward. For more information, contact the GPO Customer Contact Center, U.S. Government Publishing Office. Phone 202-512-1800 or 866-512- 1800 (toll free). E-mail, gpocusthelp.com. The annual subscription price for the Federal Register paper edition is $860 plus postage, or $929, for a combined Federal Register, Federal Register Index and List of CFR Sections Affected (LSA) subscription; the microfiche edition of the Federal Register including the Federal Register Index and LSA is $330, plus postage. Six month subscriptions are available for one-half the annual rate. The prevailing postal rates will be applied to orders according to the delivery method requested. The price of a single copy of the daily Federal Register, including postage, is based on the number of pages: $11 for an issue containing less than 200 pages; $22 for an issue containing 200 to 400 pages; and $33 for an issue containing more than 400 pages. Single issues of the microfiche edition may be purchased for $3 per copy, including postage. Remit check or money order, made payable to the Superintendent of Documents, or charge to your GPO Deposit Account, VISA, MasterCard, American Express, or Discover. Mail to: U.S. Government Publishing Office—New Orders, P.O. Box 979050, St. Louis, MO 63197-9000; or call toll free 1-866-512-1800, DC area 202-512-1800; or go to the U.S. Government Online Bookstore site, see bookstore.gpo.gov. There are no restrictions on the republication of material appearing in the Federal Register. How To Cite This Publication: Use the volume number and the page number. Example: 85 FR 12345. Postmaster: Send address changes to the Superintendent of Documents, Federal Register, U.S. Government Publishing Office, Washington, DC 20402, along with the entire mailing label from the last issue received. VerDate Sep 11 2014 20:47 Mar 31, 2020 Jkt 250001 PO 00000 Frm 00002 Fmt 4710 Sfmt 4710 E:\FR\FM\01APWS.LOC 01APWS jbell on DSKJLSW7X2PROD with FR_WS III Contents Federal Register Vol. 85, No. 63 Wednesday, April 1, 2020 Agricultural Marketing Service Coast Guard PROPOSED RULES PROPOSED RULES Exceptions to Geographic Boundaries, 18155–18156 Special Local Regulations: Upper Potomac River, National Harbor, MD, 18157–18160 Agriculture Department See Agricultural Marketing Service Commerce Department See Animal and Plant Health Inspection Service See Economic Development Administration See Forest Service See International Trade Administration NOTICES See National Oceanic and Atmospheric Administration Solicitation of Input From Stakeholders on Agricultural Innovations, 18185 Consumer Product Safety Commission RULES Air Force Department Revisions to Safety Standard for Children’s Folding Chairs NOTICES and Stools, 18111–18114 Environmental Impact Statements; Availability, etc.: Noise of Cancellation of Scoping Meetings for Proposed Defense Department Mortar and Artillery Training at Richardson Training See Air Force Department Area, Joint Base Elmendorf-Richardson, AK, 18217 See Engineers Corps Software and Documentation for Licensing, 18217–18218 See Navy Department PROPOSED RULES Alcohol, Tobacco, Firearms, and Explosives Bureau Federal Acquisition Regulations: NOTICES Construction Contract Administration, 18181–18184 Agency Information Collection Activities; Proposals, Submissions, and Approvals: Drug Enforcement Administration Application for Federal Firearms License, 18275–18276 NOTICES Importer of Controlled Substances Application: Animal and Plant Health Inspection Service Shertech Laboratories, LLC, 18277 NOTICES Wildlife Laboratories, Inc., 18276 Proposed Revision To Import Requirements for the Importation of Fresh Citrus From South Africa Into the United States, 18185–18186 Economic Development Administration NOTICES Bureau of Consumer Financial Protection Petitions by Firms for Determination of Eligibility To Apply for Trade Adjustment Assistance, 18188–18189 NOTICES Request for Information: Assist the Taskforce on Federal Consumer Financial Law, Education Department 18214–18217 NOTICES Agency Information Collection Activities; Proposals, Centers for Disease Control and Prevention Submissions, and Approvals: NOTICES Migrant Education Program Regulations and Certificate of Meetings: Eligibility, 18220 Disease, Disability, and Injury Prevention and Control Special Emphasis Panel, 18243 Energy Department See Federal Energy Regulatory Commission Centers for Medicare & Medicaid Services See National Nuclear Security Administration NOTICES Medicare and Medicaid Programs: Engineers Corps Application From the Joint Commission for Continued NOTICES Approval of Its Home Health Agency Accreditation Environmental Impact Statements; Availability, etc.: Program, 18245–18247 2007 Folsom Dam Safety and Flood Damage Reduction, Medicare Program: 18219–18220 Approval of Application by the Utilization Review Sacramento Weir Component (Yolo County, CA) of the Accreditation Commission for Initial CMS-Approval American River Watershed Common Features Project, of Its Home Infusion Therapy Accreditation Program, as Authorized Under the Water Resources 18243–18245 Development Act of 2016, 18218–18219 Civil Rights Commission Environmental Protection Agency NOTICES RULES Meetings: Air Quality State Implementation Plans; Approvals and Indiana Advisory Committee, 18187–18188 Promulgations: Pennsylvania Advisory Committee, 18188 Tennessee: Chattanooga NSR Reform, 18126–18129 VerDate Sep<11>2014 21:45 Mar 31, 2020 Jkt 250001 PO 00000 Frm 00001 Fmt 4748 Sfmt 4748 E:\FR\FM\01APCN.SGM 01APCN jbell on DSKJLSW7X2PROD with CONTENTS IV Federal Register / Vol. 85, No. 63 / Wednesday, April 1, 2020 / Contents PROPOSED RULES Federal Energy Regulatory Commission Air Quality State Implementation Plans; Approvals and NOTICES Promulgations: Combined Filings, 18223–18224 Vermont; Infrastructure State Implementation Plan Environmental Assessments; Availability, etc.: Requirements for the 2015 Ozone Standard, 18160– National Fuel Gas Supply Corp.; Amendment to West 18173 Side Expansion and Modernization Project, 18221– Modification of Significant New Uses of Certain Chemical 18222 Substances, 18173–18179 Extension of Time Request: Revocation of Significant New Use Rule for a Certain Transcontinental Gas Pipe Line Co., LLC, 18224–18225 Chemical Substance, 18179–18181 Initial Market-Based Rate Filings Including
Load more

Recommended publications
  • Evaluation of Fluralaner and Afoxolaner Treatments to Control Flea
    Dryden et al. Parasites & Vectors (2016) 9:365 DOI 10.1186/s13071-016-1654-7 RESEARCH Open Access Evaluation of fluralaner and afoxolaner treatments to control flea populations, reduce pruritus and minimize dermatologic lesions in naturally infested dogs in private residences in west central Florida USA Michael W. Dryden1*, Michael S. Canfield2, Kimberly Kalosy1, Amber Smith1, Lisa Crevoiserat1, Jennifer C. McGrady1, Kaitlin M. Foley1, Kathryn Green2, Chantelle Tebaldi2, Vicki Smith1, Tashina Bennett1, Kathleen Heaney3, Lisa Math3, Christine Royal3 and Fangshi Sun3 Abstract Background: A study was conducted to evaluate and compare the effectiveness of two different oral flea and tick products to control flea infestations, reduce pruritus and minimize dermatologic lesions over a 12 week period on naturally infested dogs in west central FL USA. Methods: Thirty-four dogs with natural flea infestations living in 17 homes were treated once with a fluralaner chew on study day 0. Another 27 dogs living in 17 different homes were treated orally with an afoxolaner chewable on day 0, once between days 28–30 and once again between days 54–60. All products were administered according to label directions by study investigators. Flea populations on pets were assessed using visual area counts and premise flea infestations were assessed using intermittent-light flea traps on days 0, 7, 14, 21, and once between days 28–30, 40–45, 54–60 and 82–86. Dermatologic assessments were conducted on day 0 and once monthly. Pruritus assessments were conducted by owners throughout the study. No concurrent treatments for existing skin disease (antibiotics, anti-inflammatories, anti-fungals) were allowed.
    [Show full text]
  • B Commission Regulation (Eu)
    02010R0037 — EN — 29.09.2018 — 035.001 — 1 This text is meant purely as a documentation tool and has no legal effect. The Union's institutions do not assume any liability for its contents. The authentic versions of the relevant acts, including their preambles, are those published in the Official Journal of the European Union and available in EUR-Lex. Those official texts are directly accessible through the links embedded in this document ►B COMMISSION REGULATION (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin (Text with EEA relevance) (OJ L 15, 20.1.2010, p. 1) Amended by: Official Journal No page date ►M1 Commission Regulation (EU) No 758/2010 of 24 August 2010 L 223 37 25.8.2010 ►M2 Commission Regulation (EU) No 759/2010 of 24 August 2010 L 223 39 25.8.2010 ►M3 Commission Regulation (EU) No 761/2010 of 25 August 2010 L 224 1 26.8.2010 ►M4 Commission Regulation (EU) No 890/2010 of 8 October 2010 L 266 1 9.10.2010 ►M5 Commission Regulation (EU) No 914/2010 of 12 October 2010 L 269 5 13.10.2010 ►M6 Commission Regulation (EU) No 362/2011 of 13 April 2011 L 100 26 14.4.2011 ►M7 Commission Regulation (EU) No 363/2011 of 13 April 2011 L 100 28 14.4.2011 ►M8 Commission Implementing Regulation (EU) No 84/2012 of 1 L 30 1 2.2.2012 February 2012 ►M9 Commission Implementing Regulation (EU) No 85/2012 of 1 L 30 4 2.2.2012 February 2012 ►M10 Commission Implementing Regulation (EU) No 86/2012 of 1 L 30 6 2.2.2012 February 2012 ►M11 Commission
    [Show full text]
  • Identification of Transcriptome and Fluralaner Responsive Genes in The
    Jia et al. BMC Genomics (2020) 21:120 https://doi.org/10.1186/s12864-020-6533-0 RESEARCH ARTICLE Open Access Identification of transcriptome and fluralaner responsive genes in the common cutworm Spodoptera litura Fabricius, based on RNA-seq Zhong-Qiang Jia1, Di Liu1, Ying-Chuan Peng1,3, Zhao-Jun Han1, Chun-Qing Zhao1* and Tao Tang2* Abstract Background: Fluralaner is a novel isoxazoline insecticide with a unique action site on the γ-aminobutyric acid receptor (GABAR), shows excellent activity on agricultural pests including the common cutworm Spodoptera litura, and significantly influences the development and fecundity of S. litura at either lethal or sublethal doses. Herein, Illumina HiSeq Xten (IHX) platform was used to explore the transcriptome of S. litura and to identify genes responding to fluralaner exposure. Results: A total of 16,572 genes, including 451 newly identified genes, were observed in the S. litura transcriptome and annotated according to the COG, GO, KEGG and NR databases. These genes included 156 detoxification enzyme genes [107 cytochrome P450 enzymes (P450s), 30 glutathione S-transferases (GSTs) and 19 carboxylesterases (CarEs)] and 24 insecticide-targeted genes [5 ionotropic GABARs, 1 glutamate-gated chloride channel (GluCl), 2 voltage-gated sodium channels (VGSCs), 13 nicotinic acetylcholine receptors (nAChRs), 2 acetylcholinesterases (AChEs) and 1 ryanodine receptor (RyR)]. There were 3275 and 2491 differentially expressed genes (DEGs) in S. litura treated with LC30 or LC50 concentrations of fluralaner, respectively. Among the DEGs, 20 related to detoxification [16 P450s, 1 GST and 3 CarEs] and 5 were growth-related genes (1 chitin and 4 juvenile hormone synthesis genes).
    [Show full text]
  • Evaluation of Fluralaner As an Oral Acaricide to Reduce Tick Infestation
    Pelletier et al. Parasites Vectors (2020) 13:73 https://doi.org/10.1186/s13071-020-3932-7 Parasites & Vectors RESEARCH Open Access Evaluation of furalaner as an oral acaricide to reduce tick infestation in a wild rodent reservoir of Lyme disease Jérôme Pelletier1,2,3*, Jean‑Philippe Rocheleau2,4, Cécile Aenishaenslin1,2,3, Francis Beaudry5, Gabrielle Dimitri Masson1,2, L. Robbin Lindsay6, Nicholas H. Ogden2,7, Catherine Bouchard2,7 and Patrick A. Leighton1,2,3 Abstract Background: Lyme disease (LD) is an increasing public health threat in temperate zones of the northern hemisphere, yet relatively few methods exist for reducing LD risk in endemic areas. Disrupting the LD transmission cycle in nature is a promising avenue for risk reduction. This experimental study evaluated the efcacy of furalaner, a recent oral aca‑ ricide with a long duration of efect in dogs, for killing Ixodes scapularis ticks in Peromyscus maniculatus mice, a known wildlife reservoir for Borrelia burgdorferi in nature. Methods: We assigned 87 mice to 3 furalaner treatment groups (50 mg/kg, 12.5 mg/kg and untreated control) administered as a single oral treatment. Mice were then infested with 20 Ixodes scapularis larvae at 2, 28 and 45 days post‑treatment and we measured efcacy as the proportion of infesting larvae that died within 48 h. At each infesta‑ tion, blood from 3 mice in each treatment group was tested to obtain furalaner plasma concentrations (C p). Results: Treatment with 50 mg/kg and 12.5 mg/kg furalaner killed 97% and 94% of infesting larvae 2 days post‑treat‑ ment, but no signifcant efect of treatment on feeding larvae was observed 28 and 45 days post‑treatment.
    [Show full text]
  • WAAVP2019-Abstract-Book.Pdf
    27th Conference of the World Association for the Advancement of Veterinary Parasitology JULY 7 – 11, 2019 | MADISON, WI, USA Dedicated to the legacy of Professor Arlie C. Todd Sifting and Winnowing the Evidence in Veterinary Parasitology @WAAVP2019 @WAAVP_2019 Abstract Book Joint meeting with the 64th American Association of Veterinary Parasitologists Annual Meeting & the 63rd Annual Livestock Insect Workers Conference WAAVP2019 27th Conference of the World Association for the Advancements of Veterinary Parasitology 64th American Association of Veterinary Parasitologists Annual Meeting 1 63rd Annualwww.WAAVP2019.com Livestock Insect Workers Conference #WAAVP2019 Table of Contents Keynote Presentation 84-89 OA22 Molecular Tools II 89-92 OA23 Leishmania 4 Keynote Presentation Demystifying 92-97 OA24 Nematode Molecular Tools, One Health: Sifting and Winnowing Resistance II the Role of Veterinary Parasitology 97-101 OA25 IAFWP Symposium 101-104 OA26 Canine Helminths II 104-108 OA27 Epidemiology Plenary Lectures 108-111 OA28 Alternative Treatments for Parasites in Ruminants I 6-7 PL1.0 Evolving Approaches to Drug 111-113 OA29 Unusual Protozoa Discovery 114-116 OA30 IAFWP Symposium 8-9 PL2.0 Genes and Genomics in 116-118 OA31 Anthelmintic Resistance in Parasite Control Ruminants 10-11 PL3.0 Leishmaniasis, Leishvet and 119-122 OA32 Avian Parasites One Health 122-125 OA33 Equine Cyathostomes I 12-13 PL4.0 Veterinary Entomology: 125-128 OA34 Flies and Fly Control in Outbreak and Advancements Ruminants 128-131 OA35 Ruminant Trematodes I Oral Sessions
    [Show full text]
  • Cover Memo Isoxazolines Inquires
    Name: Isoxazoline inquiries DATE:10/1/2018 This serves as the response to your Freedom of Information Act (FOIA) request for records regarding adverse event reports received for afoxolaner, fluralaner, lotilaner and sarolaner. A search of CVM’s Adverse Drug Event (ADE) database was performed on 10-01-2018. The search parameters were: Active ingredient(s): afoxolaner, fluralaner, lotilaner and sarolaner Reports received: From 09-04-2013 through 07-31-2018 Case type: Spontaneous ADE report Species: All Route of administration: All For each drug (active ingredient), we have provided the ‘CVM ADE Comprehensive Clinical Detail Report Listing’, which is a cumulative listing of adverse experiences in reports submitted to CVM. General Information about CVM’s ADE Database The primary purpose for maintaining the CVM ADE database is to provide an early warning or signaling system to CVM for adverse effects not detected during pre-market testing of FDA- approved animal drugs and for monitoring the performance of drugs not approved for use in animals. Information from these ADE reports is received and coded in an electronic FDA/CVM ADE database. CVM scientists use the ADE database to make decisions about product safety which may include changes to the label or other regulatory action. CVM’s ADE reporting system depends on detection and voluntary reporting of adverse clinical events by veterinarians and animal owners. The Center's ADE review process is complex, and for each report takes into consideration confounding factors such as: Dosage Concomitant drug use The medical and physical condition of animals at the time of treatment Environmental and management information Product defects Name: Isoxazoline inquiries DATE:10/1/2018 Extra-label (off label) uses The specifics of these complex factors cannot be addressed in the CVM ADE Comprehensive Clinical Detail Report Listing.
    [Show full text]
  • Preventing Unsafe Chemicals in Food Using Triple Quadrupole LC/MS
    WWW.FOODQUALITYANDSAFETY.COM You Are What You Eat Preventing Unsafe Chemicals In Food Using Triple Quadrupole LC/MS Sponsored by: Unbelievably Robust, Remarkably Versatile Trying to keep up with growing demands and challenges in the lab can be an overwhelming task. At Agilent, we are consistently innovating to help you meet those needs. We’ve taken the trusted 6470A LC/TQ and added some new features to this workhorse. The 6470B LC/TQ is enhanced to maximize productivity with new technology for reduced downtime. Now you don’t have to choose between rock-solid performance and flexibility. Visit www.agilent.com/chem/6470B © Agilent Technologies, Inc. 2021 Contents From The Editor www.foodqualityandsafety.com By Samara E. Kuehne esticide residues that remain in or on vegetables, 3 fruits, herbs, honey, oil, seeds, and food of animal From the Editor Porigin can pose major threats to human health and to the environment. Improperly used veterinary drugs BY SAMARA E. KUEHNE and antibiotics can accumulate in food derived from animals, which can also adversely affect consumers. 4 Additionally, mycotoxins, produced primarily by the As- pergillus, Penicillium, and Fusarium fungi, have the po- Comprehensive LC/MS/MS Workflow of tential to contaminate a variety of common foods, such Pesticide Residues in High Water, High Oil, as grains, nuts, cocoa, and milk, and present an ongoing and High Starch Sample Matrices Using the challenge to food safety all along the food chain. Agilent 6470 Triple Quadrupole LC/MS System Limiting exposure to these potentially life-threatening contaminants in food and animal feed is critically im- BY AIMEI ZOU, SASHANK PILLAI, PETER KORNAS, MELANIE SCHOBER, portant.
    [Show full text]
  • A Randomized, Controlled Field Study to Assess the Efficacy and Safety Of
    Karadzovska et al. Parasites & Vectors (2017) 10:528 DOI 10.1186/s13071-017-2469-x RESEARCH Open Access A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (Credelio™)in eliminating fleas in client-owned dogs in the USA Daniela Karadzovska1, Kimberly Chappell2, Shane Coble2, Martin Murphy3, Daniela Cavalleri3, Scott Wiseman4, Jason Drake2* and Steve Nanchen3 Spanish version: Please see Additional file 1 (https://doi.org/10.1186/s13071-017-2469-x) for the Spanish version of this article and Additional file 2 for the French translation of the Abstract. Abstract Background: Preclinical studies have shown that the novel isoxazoline, lotilaner (Credelio™, Elanco) administered orally to dogs, produces rapid flea and tick knockdown and sustained speed of kill for at least a month post- treatment with a wide safety margin. A field study was undertaken to validate pre-clinical results. Methods: Dogs were enrolled at 10 veterinary clinics across the United States. Qualifying households containing up to three dogs and one primary dog with at least 10 fleas were randomized 2:1 to receive lotilaner (Credelio™,Elanco)at the recommended minimum dose of 20 mg/kg, or afoxolaner (Nexgard®, Merial), administered per label, to give a minimum dose of 2.5 mg/kg. Treatments were dispensed on Days 0, 30 and 60 for administration by owners; all household dogs received the same treatment as the primary dog. Post-enrollment flea and tick counts were made on primary dogs on Days 30, 60 and 90, and all dogs were assessed for tablet palatability and safety.
    [Show full text]
  • Frontline Tri-Act®) Against Haemaphysalis Longicornis Tick Infestation in Dogs Wilfried Lebon1* Julian Liebenberg2 Nadège Perier3 Doug Carithers4 Fréderic Beugnet3
    Efficacy of a Single Spot-on Administration of Fipronil and Permethrin (Frontline Tri-act®) Against Haemaphysalis longicornis Tick Infestation in Dogs Wilfried Lebon1* Julian Liebenberg2 Nadège Perier3 Doug Carithers4 Fréderic Beugnet3 1Boehringer Ingelheim, Saint-Vulbas, France 2Clinvet, Universitas, Bloemfontein, South Africa 3Boehringer Ingelheim, Lyon, France 4Boehringer Ingelheim, Animal Health USA Inc., Duluth, USA *E-mail: [email protected] KEY WORDS: Haemaphysalis longicornis, formed at 24 hours post-infestations on Days fipronil, permethrin, Frontline Tri-Act, dog, 8, 15, 22, and 29, and ticks were removed efficacy. and counted at 48 hours post-treatment (on Day 2) and after each tick infestation on ABSTRACT Days 9, 16, 23, and 30. Acaricidal efficacies A blinded controlled laboratory study was for 24h thumb-counts were 100%, 98.8%, conducted to assess the acaricidal efficacy of 91.7%, and 84.4% on Days 8, 15, 22, and the fipronil/permethrin spot-on formulation 29, respectively. Efficacies of 98.1%, 100%, (Frontline Tri-Act®, Boehringer Ingelheim) 100%, 98.1%, and 94.7% were determined against Haemaphysalis longicornis ticks. based on removal counts performed on Days Fourteen healthy dogs were included in this 2, 9, 16, 23, and 30, respectively. There were study. Dogs in Group 1 served as untreated significant differences of the number of live controls while dogs in Group 2 were treated with Frontline Tri-Act on Day 0 at the ticks between treated and control group at minimum recommended dose of 0.1 mL/ each time-point (p <0.005). A single topical kg, corresponding to 6.76 mg/kg fipronil, administration of the combination of fipronil and 50.48 mg/kg permethrin.
    [Show full text]
  • (Credelio™) Against Haemaphysalis Longicornis Infestations of Dogs
    Otaki et al. Parasites & Vectors (2018) 11:448 https://doi.org/10.1186/s13071-018-3032-0 RESEARCH Open Access Laboratory evaluation of the efficacy of lotilaner (Credelio™) against Haemaphysalis longicornis infestations of dogs Hiroshi Otaki1, Junko Sonobe1, Martin Murphy2, Daniela Cavalleri2, Wolfgang Seewald2, Jason Drake3* and Steve Nanchen2 Abstract Background: Throughout Japan, Korea and China, Haemaphysalis longicornis ticks are vectors of Babesia gibsoni, which causes severe and progressive anemia in dogs. This study evaluated the efficacy of a single administration of lotilaner flavored chewable tablets (CredelioTM) against experimental canine H. longicornis infestations. Methods: Twenty-two healthy Beagles were ranked in descending order of counts of H. longicornis completed 48 h after challenge on Day -7. The 16 dogs with the highest live tick counts were blocked into pairs and within pairs randomized to either lotilaner-treatment at a minimum dose rate of 20 mg/kg or sham-treated controls. Treatment was administered within 30 ± 5 min following feeding on Day 0. Infestations with 50 unfed adult H. longicornis were completed on Days -2, 7, 14, 21, 28 and 35. Elizabethan collars were placed for 48 (± 2) h after each infestation and a T-shirt was placed on each dog to facilitate attachment. Ticks were counted in situ 12 and 24 h post-treatment and counted and removed after an additional 24 h (48 h after treatment) and 48 h after each post- treatment infestation. Dogs were sedated for tick challenges and counts. Live attached ticks on each dog were counted for efficacy assessments. Lotilaner was considered effective if the average tick attachment rate in the control group was at least 20%, if there was a statistically significant difference (P < 0.05) in mean tick counts between treated and control groups, and if the lotilaner-treated group had a calculated efficacy of at least 90%.
    [Show full text]
  • AAVP 2020 Annual Meeting Proceedings
    Proceedings AAVP American Association of Veterinary Parasitologists Progressive Solutions for Age-Old Problems Membership Directory 65th Annual Meeting Virtual Meeting June 20–23, 2020 Reproduced with permission from Dr. Russell Avramenko and Dr. John Gilleard and cover of International Journal for Parasitology 49,1 6/18/2020 7:35:12 AM American Association of Veterinary Parasitologists 65th Annual Meeting, June 20th – 23rd 2020, Virtual Meeting 2020 AAVP-Boehringer Ingelheim Distinguished Veterinary Parasitologist Sharon Patton, MS, PhD Sharon Patton was born on a farm in Watertown, TN to Virginia Bland and Charles Patton. She was the middle child with an older brother and two younger sisters. Her father was an “egg peddler” and sold eggs door to door in what is now considered the “greater Nashville” area. In the summer, Sharon went with her father to sell eggs 2 days/week – leaving at 4 am and returning around 7 pm. It was hard work for a little girl carrying buckets full of eggs door to door, but she loved it and gradually began to deliver more eggs than her father (although she always slept during the 50-mile drive home). The family moved from the farm where they were living with her grandparents to the small town of Watertown, but the egg peddling continued as did raising Black Angus cattle, and her father tending to 10,000 chickens that he managed in chicken houses on the farm. Later the family returned to the farm and built a house across the road from the grandparents’ house. Her father died while she was in college.
    [Show full text]
  • Lecture Overview Meet Kenny
    CVMA-SBCV Chapter Fall Conference and Trade Show Isoxazolines November 3rd 2019 Lecture overview ‣ Introduction ‣ Mechanism of action ‣ Disadvantage ‣ Advantages ‣ Extra-label use ‣ Implications for practice CONFIDENTIAL INFORMATION - MARS INC. 1 Meet Kenny https://www.canadianveterinarians.net/documents/wcv-summer-2019 CONFIDENTIAL INFORMATION - MARS INC. 2 Dr. Vincent Defalque Diplomate of the American College of Veterinary Dermatology North West Veterinary Dermatology Services CVMA-SBCV Chapter Fall Conference and Trade Show Isoxazolines November 3rd 2019 Meet Kenny ‣ 6 month-old intact male Australian Shepherd. ‣ Seen at North West Veterinary Dermatology Specialists in September 2015. ‣ Demodicosis lesions predominantly facial. ‣ Also had a severe secondary bacterial pyoderma caused by methicillin- resistant Staphylococcus pseudintermedius. ‣ Severe pruritus. Needed to wear an Elizabethan collar 24/7! ‣ Considering the age, but most importantly the breed of the patient (a well know ivermetin sensitive breed), I decided it was a great opportunity to treat my first case of canine demodicosis with oral fluralaner. CONFIDENTIAL INFORMATION - MARS INC. 3 Single dose of oral fluralaner before and after pictures Day 0 Day 44 CONFIDENTIAL INFORMATION - MARS INC. 4 Dr. Vincent Defalque Diplomate of the American College of Veterinary Dermatology North West Veterinary Dermatology Services CVMA-SBCV Chapter Fall Conference and Trade Show Isoxazolines November 3rd 2019 Introduction ‣ Flea and tick infestation is a major health problem in dogs and cats. ‣ Control presents an economic burden to pet owners. ‣ Recent advances in product technology have greatly expanded the available options for veterinarians and pet owners. ‣ Afoxolaner, fluralaner, lotilaner and sarolaner are novel synthetic members of the isoxazoline class of parasiticides showing activity against insects and acarines, including fleas and ticks.
    [Show full text]