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The Rhesus Factor and Disease Prevention
THE RHESUS FACTOR AND DISEASE PREVENTION The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 3 June 2003 Edited by D T Zallen, D A Christie and E M Tansey Volume 22 2004 ©The Trustee of the Wellcome Trust, London, 2004 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2004 The Wellcome Trust Centre for the History of Medicine at University College London is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 0 85484 099 1 Histmed logo images courtesy Wellcome Library, London. Design and production: Julie Wood at Shift Key Design 020 7241 3704 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as : Zallen D T, Christie D A, Tansey E M. (eds) (2004) The Rhesus Factor and Disease Prevention. Wellcome Witnesses to Twentieth Century Medicine, vol. 22. London: Wellcome Trust Centre for the History of Medicine at UCL. CONTENTS Illustrations and credits v Witness Seminars: Meetings and publications;Acknowledgements vii E M Tansey and D A Christie Introduction Doris T Zallen xix Transcript Edited by D T Zallen, D A Christie and E M Tansey 1 References 61 Biographical notes 75 Glossary 85 Index 89 Key to cover photographs ILLUSTRATIONS AND CREDITS Figure 1 John Walker-Smith performs an exchange transfusion on a newborn with haemolytic disease. Photograph provided by Professor John Walker-Smith. Reproduced with permission of Memoir Club. 13 Figure 2 Radiograph taken on day after amniocentesis for bilirubin assessment and followed by contrast (1975). -
Bourne Lecture
“One Medicine: the Continuum of Medicine, Veterinary Medicine and Biomedical Science”. Bourne Lecture. 12th February 2007. St Georges Medical School , Grenada. Ian McConnell , Professor of Veterinary Science, Department of Veterinary Medicine, University of Cambridge, England, United Kingdom. Introduction. Chancellor, Provost , Ladies and Gentlemen. Thank you , Provost, for your generous introduction. It is indeed an honour to be invited to give this years Bourne lecture in memory of Geoffrey Bourne . Geoffrey Bourne , your first Vice Chancellor who as an educator and scientist who had the vision to create here in this marvellous country of Grenada a most remarkable medical school which later evolved under the leadership of Keith Taylor, as Vice Chancellor, into what is today- a thriving and confident young University. St George’s University is an internationally recognised institution of higher education which has set a dynamic global perspective and can rightly claim to be a stratgically important landmark of learning in the West Indies. In this lecture I am going to address the topic of “ One Medicine”. I have chosen this as a topic because it seems appropriate to the St. George’s Medical School and the close relationship it has with the veterinary school. The development of the veterinary school owes much to the foresight and drive of Peter Bourne, who as Vice Chancellor, fostered the development of veterinary medicine. In the long history of both the Medical and the Veterinary Professions and the education of undergraduates in both there has always been a healthy interaction between medicine, veterinary medicine as well as biomedical science. The co-location of a medical school with a veterinary school which you have here is one way to promote this interaction . -
Immune Effector Mechanisms and Designer Vaccines Stewart Sell Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, USA
EXPERT REVIEW OF VACCINES https://doi.org/10.1080/14760584.2019.1674144 REVIEW How vaccines work: immune effector mechanisms and designer vaccines Stewart Sell Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, USA ABSTRACT ARTICLE HISTORY Introduction: Three major advances have led to increase in length and quality of human life: Received 6 June 2019 increased food production, improved sanitation and induction of specific adaptive immune Accepted 25 September 2019 responses to infectious agents (vaccination). Which has had the most impact is subject to debate. KEYWORDS The number and variety of infections agents and the mechanisms that they have evolved to allow Vaccines; immune effector them to colonize humans remained mysterious and confusing until the last 50 years. Since then mechanisms; toxin science has developed complex and largely successful ways to immunize against many of these neutralization; receptor infections. blockade; anaphylactic Areas covered: Six specific immune defense mechanisms have been identified. neutralization, cytolytic, reactions; antibody- immune complex, anaphylactic, T-cytotoxicity, and delayed hypersensitivity. The role of each of these mediated cytolysis; immune immune effector mechanisms in immune responses induced by vaccination against specific infectious complex reactions; T-cell- mediated cytotoxicity; agents is the subject of this review. delayed hypersensitivity Expertopinion: In the past development of specific vaccines for infections agents was largely by trial and error. With an understanding of the natural history of an infection and the effective immune response to it, one can select the method of vaccination that will elicit the appropriate immune effector mechanisms (designer vaccines). These may act to prevent infection (prevention) or eliminate an established on ongoing infection (therapeutic). -
Genetic Testing
GENETIC TESTING The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 13 July 2001 Edited by D A Christie and E M Tansey Volume 17 2003 CONTENTS Illustrations v Introduction Professor Peter Harper vii Acknowledgements ix Witness Seminars: Meetings and publications xi E M Tansey and D A Christie Transcript Edited by D A Christie and E M Tansey 1 References 73 Biographical notes 91 Glossary 105 Index 115 ILLUSTRATIONS Figure 1 Triploid cells in a human embryo, 1961. 20 Figure 2 The use of FISH with DNA probes from the X and Y chromosomes to sex human embryos. 62 v vi INTRODUCTION Genetic testing is now such a widespread and important part of medicine that it is hard to realize that it has almost all emerged during the past 30 years, with most of the key workers responsible for the discoveries and development of the field still living and active. This alone makes it a suitable subject for a Witness Seminar but there are others that increase its value, notably the fact that a high proportion of the critical advances took place in the UK; not just the basic scientific research, but also the initial applications in clinical practice, particularly those involving inherited disorders. To see these topics discussed by the people who were actually involved in their creation makes fascinating reading; for myself it is tinged with regret at having been unable to attend and contribute to the seminar, but with some compensation from being able to look at the contributions more objectively than can a participant. -
Medical Bacteriology
LECTURE NOTES Degree and Diploma Programs For Environmental Health Students Medical Bacteriology Abilo Tadesse, Meseret Alem University of Gondar In collaboration with the Ethiopia Public Health Training Initiative, The Carter Center, the Ethiopia Ministry of Health, and the Ethiopia Ministry of Education September 2006 Funded under USAID Cooperative Agreement No. 663-A-00-00-0358-00. Produced in collaboration with the Ethiopia Public Health Training Initiative, The Carter Center, the Ethiopia Ministry of Health, and the Ethiopia Ministry of Education. Important Guidelines for Printing and Photocopying Limited permission is granted free of charge to print or photocopy all pages of this publication for educational, not-for-profit use by health care workers, students or faculty. All copies must retain all author credits and copyright notices included in the original document. Under no circumstances is it permissible to sell or distribute on a commercial basis, or to claim authorship of, copies of material reproduced from this publication. ©2006 by Abilo Tadesse, Meseret Alem All rights reserved. Except as expressly provided above, no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission of the author or authors. This material is intended for educational use only by practicing health care workers or students and faculty in a health care field. PREFACE Text book on Medical Bacteriology for Medical Laboratory Technology students are not available as need, so this lecture note will alleviate the acute shortage of text books and reference materials on medical bacteriology. -
Centenary of the Death of Elie Metchnikoff: a Visionary and an Outstanding Team Leader
+ MODEL Microbes and Infection xx (2016) 1e18 www.elsevier.com/locate/micinf Review Centenary of the death of Elie Metchnikoff: a visionary and an outstanding team leader Jean-Marc Cavaillon a,*, Sandra Legout b a Unit Cytokines & Inflammation, Institut Pasteur, 28 Rue Dr. Roux, 75015 Paris, France b Centre de Ressources en Information Scientifique, Institut Pasteur, 28 Rue Dr. Roux, 75015 Paris, France Received 22 April 2016; accepted 26 May 2016 Available online ▪▪▪ Abstract Elie Metchnikoff passed away on July 15th, 1916. He is considered to be the father of phagocytes, cellular innate immunity, probiotics, and gerontology. In all of these fields, he was a visionary. To achieve such a notability and produce so many masterpieces, Metchnikoff used more than 30 animal species to support his findings, and his pasteurian laboratory published more than 200 papers in the Annales de l’Institut Pasteur. As a wonderful team leader and a great mentor, during his 28 years at Institut Pasteur, he welcomed and supervised more than 100 young trainees. Trained as an embryologist, he contributed to the birth of immunology and to the understanding of physiology and pathology. Indeed, Metchnikoff and his team investigated inflammation in guinea pigs, rats, frogs; studied infectious diseases in monkeys, caimans, geese; investigated aging in parrots, dogs, humans; proposed hypotheses to understand age-associated senility using rabbits and humans; developed germ free tadpoles, flies, chicks; studied the gut flora in bats, horses, birds, humans; and popularized the use of probiotics as a tool to delay the deleterious effects of toxic compounds derived from putrefactive gut bacteria. -
Module 2: Diphtheria
The Immunological Basis for Immunization Series Module 2: Diphtheria DEPARTMENT OF VACCINES AND BIOLOGICALS ~-) World Health Organization ~ ~ fJ! Geneva ----~ WHO/EPI/GEN/93.12 ORIGINAL: ENGLISH DISTR.: GENERAL The Immunological Basis for Immunization Series Module 2: Diphtheria Dr Artur M. Galazka Medical Officer Expanded Programme on Immunization DEPARTMENT OF VACCINES AND BIOLOGICALS .) World Health Organization ~ , ~ ~ Geneva ~ I iJff 2001 ~~ The Department of Vaccines and Biologicals thanks the donors whose unspecified financial support has made the production of this document possible. United Nations Development Fund (UNDP) The Rockefeller Foundation The Government of Sweden The Immunological Basis for Immunization series is available in English and French (from the address below). It has also been translated by national health authorities into a number of other languages for local use: Chinese, Italian, Persian, Russian, Turkish, Ukranian and Vietnamese. The series comprises eight independent modules: Module 1: General immunology Module 2: Diphtheria Module 3: Tetanus Module 4: Pertussis Module 5: Tuberculosis Module 6: Poliomyelitis Module 7: Measles Module 8: Yellow fever Produced in 1993 Reprinted (with new covers but no changes to content) in 2001 Ordering code: WHO/EPI/GEN/93.12 This document is available on the Internet at: www.who.int/vaccines-documents/ Copies may be requested from: World Health Organization Department of Vaccines and Biologicals CH-1211 Geneva 27, Switzerland • Fax: + 41 22 791 4227 • £-mail: [email protected] • ©World Health Organization 2001 This document is not a formal publication of the World Health Organization (WHO), and all rights are reserved by the Organization. The document may, however, be freely reviewed, abstracted, reproduced and translated, in part or in whole, but not for sale nor for use in conjunction with commercial purposes. -
Coombs Test Direct Vs Indirect Hoodcity
Coombs Test Direct Vs Indirect Epistolary and sunlit Tad lathees almost errantly, though Iain handsels his intima tooms. Jasper invaded probabilistically? If dodgy or sensualistic Roice usually peptonizes his Med dragging somehow or minimizing next and subtly, how Johnsonian is Gideon? Named after which the coombs test vs indirect antiglobulin tests are also be administered Much of circulating, if you may vary in addition to rh factor and identification. Incubate the coombs test is rh positive it was too early. Off disease is called antibodies produced against foreign red blood is being tested get coated the test. Realized the red blood is no antibodies with relevant or stinging. Muscle to detect the blood sample should not made by dr robin coombs. Binds to do the direct coombs results mean that once the final phase of an rh sensitization. Coated the iat; thanks for the direct coombs test in its full name and in writing. Morning urine sample is relatively rare occurance, dysregulation of both positives, and the ahg. Vivo antibody test direct coombs test is where the cells by the role of d is detected in lower the back. Increased immunoglobulin coating target human, and a posttransfusion specimen requirement, i have the results. Suggests that attack harmful to blood cells is not provide and incubated. Stop the test direct vs indirect coombs test, the naked eye at all reasonable care in brucellosis and funny blog post above to high protein called rh antigens. Ig antibodies on the test is unrecognized and you refresh my discussion to their mother who invented it with the post for. -
Wellcome Witnesses to Twentieth Century Medicine
WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _______________________________________________________________ TECHNOLOGY TRANSFER IN BRITAIN: THE CASE OF MONOCLONAL ANTIBODIES ______________________________________________ SELF AND NON-SELF: A HISTORY OF AUTOIMMUNITY ______________________ ENDOGENOUS OPIATES _____________________________________ THE COMMITTEE ON SAFETY OF DRUGS __________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY P P CATTERALL D A CHRISTIE S V WILLHOFT L A REYNOLDS Volume One – April 1997 CONTENTS WHAT IS A WITNESS SEMINAR? i E M TANSEY TECHNOLOGY TRANSFER IN BRITAIN: THE CASE OF MONOCLONAL ANTIBODIES EDITORS: E M TANSEY AND P P CATTERALL TRANSCRIPT 1 INDEX 33 SELF AND NON-SELF: A HISTORY OF AUTOIMMUNITY EDITORS: E M TANSEY, S V WILLHOFT AND D A CHRISTIE TRANSCRIPT 35 INDEX 65 ENDOGENOUS OPIATES EDITORS: E M TANSEY AND D A CHRISTIE TRANSCRIPT 67 INDEX 100 THE COMMITTEE ON SAFETY OF DRUGS EDITORS: E M TANSEY AND L A REYNOLDS TRANSCRIPT 103 INDEX 133 WHAT IS A WITNESS SEMINAR? Advances in medical science and medical practice throughout the twentieth century, and especially after the Second World War, have proceeded at such a pace, and with such an intensity, that they provide new and genuine challenges to historians. Scientists and clinicians themselves frequently bemoan the rate at which published material proliferates in their disciplines, and the near impossibility of ‘keeping up with the literature’. Pity, then, the poor historian, trying to make sense of this mass of published data, scouring archives for unpublished accounts and illuminating details, and attempting throughout to comprehend, contextualize, reconstruct and convey to others the stories of the recent past and their significance. The extensive published record of modern medicine and medical science raises particular problems for historians: it is often presented in a piecemeal but formal fashion, sometimes seemingly designed to conceal rather than reveal the processes by which scientific medicine is conducted. -
Le Centenaire De La Naissance De Constantin LEVADITI (1874-1953)
Le centenaire de la naissance de Constantin LEVADITI (1874-1953) par le Docteur Radu IFTTIMOVICI * (Bucarest) Cette année, l'Unesco a inscrit à son agenda la célébration du centenaire de la naissance de Constantin Levaditi, l'un des savants les plus connus dans le domaine de la virologie, de la pathologie infectieuse et de la chimiothérapie. Roumain de naissance, Levaditi devait devenir citoyen français et l'un des chercheurs les plus appréciés de l'école pastorienne. Né en 1874 dans la ville de Galatz, grand port sur le Danube, le futur savant connut dès l'enfance une vie difficile. Ses parents, en effet, meurent avant même qu'il ait terminé l'école primaire, de sorte qu'il sera élevé par une sœur de son père, lingère à l'Hôpital « Brâncoveanu » de Bucarest. L'enfant grandira donc au milieu des malades, au spectacle de la souf france, là où l'espoir est si fragile, où souvent s'étend l'ombre de la mort. A l'âge où les autres enfants se laissent bercer par les rêves et sourient à la vie, le jeune Levaditi passe son temps libre dans les salles de l'hôpital ou dans celles d'opérations. Ainsi s'explique le fait que, depuis son enfance, son seul idéal sera de devenir médecin, de pouvoir rendre à ceux qui souffrent le plus précieux des biens : la santé. Après de brillantes études au lycée Mateï Basarab, établissement déjà connu pour ses solides traditions culturelles, le jeune Levaditi s'inscrit, en 1892, à la Faculté de Médecine de Bucarest. Devenu, au cours de ses dernières années d'études, interne des hôpitaux, il reviendra travailler à l'Hôpital « Brâncoveanu », là même où il a passé son enfance. -
Immunology of the Allergic Response 1
9781405157209_4_001.qxd 4/1/08 20:03 Page 1 1 Immunology of the Allergic Response 9781405157209_4_001.qxd 4/1/08 20:03 Page 2 .. 9781405157209_4_001.qxd 4/1/08 20:03 Page 3 1 Allergy and Hypersensitivity: History and Concepts A. Barry Kay Summary The study of allergy (“allergology”) and hypersensitivity, and the associated allergic diseases, have their roots in the science of immunology but overlap with many disciplines including pharmacology, biochemistry, cell and molecular biology, and general pathology, particularly the study of inflammation. Allergic diseases involve many organs and tissues such as the upper and lower airways, the skin, and the gastrointestinal tract and therefore the history of relevant discoveries in the field are long and complex. This chapter gives only a brief account of the major milestones in the history of allergy and the concepts which have arisen from them. It deals mainly with discoveries in Fig. 1.1 A commemorative postage stamp to mark the discovery the 19th and early 20th century, particularly the events which of anaphylaxis by Charles R. Richet (1850–1935) and Paul J. Portier followed the description of anaphylaxis and culminated in the (1866–1962). discovery of IgE as the carrier of reaginic activity. An important conceptual landmark that coincided with the considerable foreign proteins to various species including dogs (Magendie increase in knowledge of immunologic aspects of hypersensitivity 1839), guinea pigs (Von Behring 1893, quoted in Becker 1999, was the Coombs and Gell classification of hypersensitivity p. 876) and rabbits (Flexner 1894, reviewed in Bulloch 1937). reactions in the 1960s. This classification is revisited and updated However it was not until the discovery of anaphylaxis by to take into account some newer finding on the initiation of the allergic response. -
Immunology Transformations
IDecembermmunology 2018 | ISSN 1356-5559 (print) News Immunology transformations: An interview with our President, Peter Openshaw Immunology Policy talk: China at 60: Immunology goes conversations: Celebrate our journal’s to Parliament Building collaborations continued success www.immunology.org 2 ADVERTISEMENTS the life science company with a difference Nobel Prize-winner Recommendation! Bio X Cell offer a reagent portfolio specialized towards antibodies which are widely used for in vivo and in vitro antigen neutralisation and pathway blockade as well as cell specific depletion. BioXcell CTLA-A antibodies are highly recommended by James P. Allison - Corecipient of the 2018 Nobel Prize in Physiology or Medicine To view all Bio X cell products visit 2BScientific.com: Academic discounts www.2BScientific.com/Suppliers/BioXCell & bulk pricing available +44 (0)1869 238 033 www.2BScientific.com [email protected] Products are for Research Use Only – Not for Therapeutic or Diagnostic Use ™ Veri-Cells Veri ed Lyophilized Control Cells Save time, money, and reagents with Veri-Cells™, our new lyophilized human control cells for ow cytometry, validated to provide consistent assay-to- assay results. • Exceptional long term stability • Scatter pro le similar to fresh samples • Validated to detect 160+markers • Useful to monitor data quality and reproducibility in multi-center and longitudinal studies Learn more at: biolegend.com/veri-cells BioLegend is ISO 13485:2003 Certi ed Tel: 858.768.5800 biolegend.com 08-0063-16 World-Class Quality | Superior Customer Support | Outstanding Value Immunology News | December 2018 A WORD FROM THE EDITOR 3 ©Shutterstock Welcome to the December 2018 edition personnel. Firstly, we’re incredibly excited of Immunology News.