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RIKEN Center for Developmental Biology http://www.cdb.riken.jp/ RIKEN CENTER FOR DEVELOPMENTAL BIOLOGY 2-2-3 MINATOJIMA-MINAMIMACHI, CHUO-KU KOBE 650-0047 JAPAN PHONE: +81-78-306-0111 FAX: +81-78-306-0101 EMAIL: [email protected] 2015 Annual Report 2015 RIKEN Center for Developmental Biology 2015 Annual Report On The Cover 3D reconstructed image of developing mouse lung at E16.5 showing localization of epithelial and neuroen- docrine cells. Image: Laboratory for Lung Development Printed in Japan using soy inks, waterless printing methods, and paper from sustainable resources. RIKEN 2016-017 Contents 2015 2 Message from the Director 32 Hippocampal neurons from hES cells 54 Sensory Development Annual Report Lab. for Organogenesis and Neurogenesis; In Vitro Raj LADHER 4 Organizational Chart Histogenesis 6 2015 at the CDB 55 Cell Asymmetry 34 Putting a new spin on autonomously organized Fumio MATSUZAKI RIKEN epithelial movement 56 Lung Development Center for Research Highlights Lab. for Histogenetic Dynamics Mitsuru MORIMOTO Developmental Biology 36 Pulmonary neuroendocrine cell clusters at 57 Growth Control Signaling 10 Oocyte maturation directed by PLK1 airway branches Takashi NISHIMURA Lab. for Chromosome Segregation Lab. for Lung Development 58 Pluripotent Stem Cell Studies 12 Generating 3D cerebellar structure and 38 Doubling teeth from single tooth germ Hitoshi NIWA functional cerebellar neurons Lab. for Organ Regeneration 59 Early Embryogenesis Lab. for Organogenesis and Neurogenesis 40 Transplantation of hESC-derived retinal tissue in Guojun SHENG 14 Induction of retinal tissue with ciliary margin primate models of retinitis pigmentosa 60 Retinal Regeneration from hESCs Lab. for Retinal Regeneration Masayo TAKAHASHI Lab. for Organogenesis and Neurogenesis; In Vitro Histogenesis 61 Cell Adhesion and Tissue Patterning Masatoshi TAKEICHI 16 Chick embryo reveals conserved developmental Laboratories mechanisms among vertebrates 62 Organogenesis and Neurogenesis Lab. for Early Embryogenesis 44 In Vitro Histogenesis Masatoshi TAKEICHI 18 Improved donor organ preservation method for Mototsugu EIRAKU 63 Organ Regeneration transplantation 45 Tissue Microenvironment Takashi TSUJI Lab. for Organ Regeneration Hironobu FUJIWARA 64 Epithelial Morphogenesis 20 Surprising instability of meiotic cell division 46 Organismal Patterning Yu-Chiun WANG Lab. for Chromosome Segregation Hiroshi HAMADA 22 Self-organized actin pattern in the tracheal tube 47 Neocortical Development Lab. for Morphogenetic Signaling Carina HANASHIMA 65 2015 Events 24 Anchoring the signaling complex needed for cell 48 Morphogenetic Signaling 66 2015 Courses elongation Shigeo HAYASHI 67 2015 Awards Lab. for Morphogenetic Signaling 49 Developmental Epigenetics Ichiro HIRATANI 26 Leading cause of age-related aneuploidy in 70 RIKEN in Kobe oocytes revealed 50 Sensory Circuit Formation Lab. for Chromosome Segregation Takeshi IMAI 72 CDB Symposium 28 Just being naive? Early pluripotency in a bird 51 Axial Pattern Dynamics 74 Seminars model of development Hidehiko INOMATA 76 About RIKEN Lab. for Sensory Development; Early Embryogenesis 52 Chromosome Segregation 77 RIKEN Campuses 30 Nutrient-dependent regulation of growth control Tomoya KITAJIMA hormone revealed 53 Histogenetic Dynamics Lab. Growth Control Signaling Erina KURANAGA The RIKEN Center for Developmental Biology was launched molecular and cell biological level, the more complex in April 2000 under the auspices of the Millennium Project phenomena involved in organogenesis, as well as the research initiative, which was established to drive research biology of stem cells and regeneration. Scientists at the in areas of vital importance to both Japan and the world in CDB conduct world-class studies in a truly international the 21st century. The challenges of an aging society were research environment, with ample core facilities and among the issues addressed, and developmental biology technical support and a critical mass of scientific talent and was included within this remit as a scientific field with the expertise. The CDB also benefits from belonging to Japan’s potential to contribute to the development of regenerative largest basic scientific research organization, RIKEN, as medicine. well as its close ties to graduate and medical schools and research institutes in Japan and other countries, giving our Located in Kobe, Japan, the Center’s research programs scientists access to a broad network of talent and technol- are dedicated to developing a better understanding of ogy across the country and around the world. fundamental processes of animal development at the Contents 2015 2 Message from the Director 32 Hippocampal neurons from hES cells 54 Sensory Development Annual Report Lab. for Organogenesis and Neurogenesis; In Vitro Raj LADHER 4 Organizational Chart Histogenesis 6 2015 at the CDB 55 Cell Asymmetry 34 Putting a new spin on autonomously organized Fumio MATSUZAKI RIKEN epithelial movement 56 Lung Development Center for Research Highlights Lab. for Histogenetic Dynamics Mitsuru MORIMOTO Developmental Biology 36 Pulmonary neuroendocrine cell clusters at 57 Growth Control Signaling 10 Oocyte maturation directed by PLK1 airway branches Takashi NISHIMURA Lab. for Chromosome Segregation Lab. for Lung Development 58 Pluripotent Stem Cell Studies 12 Generating 3D cerebellar structure and 38 Doubling teeth from single tooth germ Hitoshi NIWA functional cerebellar neurons Lab. for Organ Regeneration 59 Early Embryogenesis Lab. for Organogenesis and Neurogenesis 40 Transplantation of hESC-derived retinal tissue in Guojun SHENG 14 Induction of retinal tissue with ciliary margin primate models of retinitis pigmentosa 60 Retinal Regeneration from hESCs Lab. for Retinal Regeneration Masayo TAKAHASHI Lab. for Organogenesis and Neurogenesis; In Vitro Histogenesis 61 Cell Adhesion and Tissue Patterning Masatoshi TAKEICHI 16 Chick embryo reveals conserved developmental Laboratories mechanisms among vertebrates 62 Organogenesis and Neurogenesis Lab. for Early Embryogenesis 44 In Vitro Histogenesis Masatoshi TAKEICHI 18 Improved donor organ preservation method for Mototsugu EIRAKU 63 Organ Regeneration transplantation 45 Tissue Microenvironment Takashi TSUJI Lab. for Organ Regeneration Hironobu FUJIWARA 64 Epithelial Morphogenesis 20 Surprising instability of meiotic cell division 46 Organismal Patterning Yu-Chiun WANG Lab. for Chromosome Segregation Hiroshi HAMADA 22 Self-organized actin pattern in the tracheal tube 47 Neocortical Development Lab. for Morphogenetic Signaling Carina HANASHIMA 65 2015 Events 24 Anchoring the signaling complex needed for cell 48 Morphogenetic Signaling 66 2015 Courses elongation Shigeo HAYASHI 67 2015 Awards Lab. for Morphogenetic Signaling 49 Developmental Epigenetics Ichiro HIRATANI 26 Leading cause of age-related aneuploidy in 70 RIKEN in Kobe oocytes revealed 50 Sensory Circuit Formation Lab. for Chromosome Segregation Takeshi IMAI 72 CDB Symposium 28 Just being naive? Early pluripotency in a bird 51 Axial Pattern Dynamics 74 Seminars model of development Hidehiko INOMATA 76 About RIKEN Lab. for Sensory Development; Early Embryogenesis 52 Chromosome Segregation 77 RIKEN Campuses 30 Nutrient-dependent regulation of growth control Tomoya KITAJIMA hormone revealed 53 Histogenetic Dynamics Lab. Growth Control Signaling Erina KURANAGA The RIKEN Center for Developmental Biology was launched molecular and cell biological level, the more complex in April 2000 under the auspices of the Millennium Project phenomena involved in organogenesis, as well as the research initiative, which was established to drive research biology of stem cells and regeneration. Scientists at the in areas of vital importance to both Japan and the world in CDB conduct world-class studies in a truly international the 21st century. The challenges of an aging society were research environment, with ample core facilities and among the issues addressed, and developmental biology technical support and a critical mass of scientific talent and was included within this remit as a scientific field with the expertise. The CDB also benefits from belonging to Japan’s potential to contribute to the development of regenerative largest basic scientific research organization, RIKEN, as medicine. well as its close ties to graduate and medical schools and research institutes in Japan and other countries, giving our Located in Kobe, Japan, the Center’s research programs scientists access to a broad network of talent and technol- are dedicated to developing a better understanding of ogy across the country and around the world. fundamental processes of animal development at the Message from the Center Director It was a great sense of pride and responsibility that I joined the RIKEN Center for Developmental Biology (CDB) as Director in April of this year. My predecessor, Dr. Masatoshi Takeichi has set an incredibly high bar of achievement through his great leadership and his long career of scientific achievements, and the success of the Center over the first 15 years of its history is a testament to his vision. My task now is to guide the CDB into a new stage of its own development, one in which we continue to bring to light the mechanisms by which the body is built, and find new ways of harnessing that knowledge in rebuilding bodies that have been damaged by illness, injury, or age. Following a reorganization of the research system last year, the CDB of 2015 is a slimmer organization, with multidisciplinary programs focused on cellular environment
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