ANTIBIOTIC SENSITIVITY CHART

Created by James McCormack, BSc(Pharm), PharmD and Fawziah Lalji, BSc(Pharm), PharmD, FCSHP with assistance from Tim Lau Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC Gram Positive Cocci Gram Negative Bacilli Gram Negative Coccobacilli Anaerobes Atypicals Streptococci Staphylococci

SPACE Non-beta-lactamase producing ESBL Bacteria Streptococci Staph Community Hospital Beta-lactamase producing Serratia marcescens, Mycoplasma Staph Escherichia coli, (Extended spectrum beta- CRE Below the (pneumoniae/ Enterococci epidermidis acquired acquired Escherichia coli, Proteus vulgaris, Pseudomonas Above the diaphragm Clostridium pneumoniae, Legionella Chlamydia lactamase producing) aureus Klebsiella pneumoniae, Acinetobacter sp., (Carapenem-resistant Neisseria meningitidis Neisseria gonorrhea diaphragm pyogenes/ (Group D strep) (coagulase (Methicillin (Methicillin Klebsiella pneumoniae, Escherichia coli, aeruginosa (Peptostreptococcus) difficile Chlamydophila pneumophila trachomatis (Methicillin sensitive) Haemophilus influenzae Citrobacter sp., Enterobacteriaceae) (Bacteroides sp) negative) resistant) resistant) Haemophilus influenzae Klebsiella pneumoniae spp viridans group) Enterobacter sp.

Brain, oral, respiratory tract, Intraabdominal, Intraabdominal, pelvic Pelvic inflammatory Location Skin, prosthetics Oral, respiratory tract, heart, skin, bones/joint Pelvic inflammatory disease/STI Oral, respiratory tract Intraabdominal Respiratory tract heart, skin urinary tract Brain, respiratory tract, intraabdominal, urinary tract Brain inflammatory disease disease/STI Pencillin V/G Pencillin G-IV Pencillin V/G Amoxicillin/ampicillin Amoxicillin/ampicillin Ampicillin-IV Amoxicillin/ampicillin Penicillins Cloxacillin Amoxicillin-clavulanate Amoxicillin-clavulanate Amoxicillin-clavulanate Amoxicillin-clavulanate Piperacillin-tazobactam Piperacillin-tazobactam Piperacillin-tazobactam Piperacillin-tazobactam Piperacillin-tazobactam Cefazolin/cephalexin Cefazolin/cephalexin Cefazolin/cephalexin Cefazolin/cephalexin Cefuroxime Cefuroxime Cefuroxime Cefuroxime Cefoxitin Cefoxitin Cefoxitin Cefoxitin Ceftriaxone/cefotaxime Ceftriaxone/cefotaxime Ceftriaxone/cefotaxime Ceftriaxone/cefotaxime Cephalosporins Cefixime Cefixime Cefixime Ceftazidime Ceftazidime Ceftolozane - tazobactam Ceftolozane-tazo Ceftolozane-tazo Cefipime Cefipime Cefipime Cefipime Cefipime Ceftibiprole Ceftibiprole

Meropenem/imipenem/doripe Meropenem/imipenem/doripenem Meropenem/imipenem/doripenem Meropenem/imipenem/doripenem Meropenem/imipenem/doripenem nem

Carbapenems Ertapenem Ertapenem Ertapenem Ertapenem Erythromycin Erythromycin Erythromycin Macrolides Clarithromycin/azithromycin Clarithromycin/azithromycin Clarithromycin/azithromycin JUST H.flu JUST azithromycin Clarithromycin/azithromycin JUST azithromycin Tetracycline/doxycycline Tetracycline/doxycycline Tetracycline/doxycycline JUST H.flu Tetracycline/doxycycline Tetracycline/doxycycline Tetracyclines Tigecycline Tigecycline Tigecycline Ciprofloxacin/norfloxacin BUT JUST bladder infections for norfloxacin Ciprofloxacin Fluoroquinolones Levofloxacin/moxifloxacin Levofloxacin/moxifloxacin Levofloxacin/moxifloxacin Moxifloxacin Levofloxacin/moxifloxacin

Gentamicin/tobra Gentamicin/tobramycin/amikacin mycin/amikacin Aminoglycosides Colistin/polymyxi Colistin/polymyxin B Polymyxin n B Lincosamides Clindamycin Clindamycin Clindamycin

Glycopeptides/lipoglycopeptides Vancomycin/daptomycin Vancomycin/daptomycin Vancomycin oral

Oxazolidinones Linezolid/tedizolid Linezolid/tedizolid Trimethoprim-Sulfamethoxazole Trimethoprim-sulfamethoxazole Trimethoprim-sulfamethoxazole Chloramphenicol Chloramphenicol Chloramphenicol Chloramphenicol Metronidazole Metronidazole Nitrofurantoin/fosfomycin Nitrofurantoin/fosfomycin Nitrofurantoin/fosfomycin Nitrofurantoin/fosfomycin (JUST BLADDER INFECTIONS) JUST E.faecalis Rifampin Rifampin Rifampin Fidaxomicin Fidaxomicin Cloxacillin and clindamycin typically have less than 40% activity for S.epidermidis, thus usage depends on local susceptibility data Enterococci has two main species - Enterococcus faecalis and Enterococcus faecium; the antibiotics listed are active against E.faecalis, but have limited activity for E.faecium Cephalosporins have in-vitro activity for SPACE organisms but induce production of beta-lactamases Tigecycline has no activity against Pseudomonas aeruginosa, but for Acinetobacter it depends on local susceptibility data; Tigecycline is active against SPACE organisms, but for Proteus spp it depends on local susceptibility data

OCTOBER 2019