Neuroscience & Electrophysiology

Bipolar Suction Electrode Optopatcher® Connectors Electrodes Capillary Glass

• With or Without Filaments • Epoxy-Insulated • Standard Boroscilicate INTRACELLULAR • Parylene-Insulated • Patch Clamp Glass With Built-In Shielding Fits All Patch Clamps, Including Axon and Heka • Suction Electrodes • Thin-Wall Glass • Bipolar • Unmatched accuracy in applying optical stimulation to an • Ag/AgCl Electrodes • Multi-Barrel Glass • Easy pin connectors for connection to amplifiers in-vivo patch-clamp protocol • Large internal volume • Simultaneous patch-clamp recording and optogenetic • Use with glass capillary pipettes, disposable pipette tips, or activation through the same electrode Patch Cords Illuminators Dental Cement small diameter tubing • Designed for glass diameters of 1.2 mm to 2.0 mm EXTRACELLULAR • Accepts capillary glass with OD between 1.2 mm – 1.5 mm • Optical fiber connects to any source cable terminating in a 1.25 mm ceramic ferrule

Wire & Rod A-M Systems offers a wide variety of fine bare, fine PATCH CLAMP insulated wires, and straightened rods for your electrode manufacturing needs. We also have the ability to provide custom diameters and lengths of any item for your unique applications. Need a custom size or length? Just ask us! A-M Systems is a leading manufacturer of high-quality, precision investigations into learning and memory, Alzheimer’s and STIMULATION neuroscience and electrophysiology instrumentation and Parkinson’s diseases, and models of stroke, deafness and blindness. supplies for the research community worldwide. Since 1976, our Our Pulmonary Division designs and develops superior unwavering commitment to product excellence, competitive Wires Bare Wire Insulated Wire Straight Rod respiratory and pulmonary care products under U.S. prices and customer service has earned us satisfied Gold 0.001" – 0.005" 0.001" – 0.005" — and international standards. Our branded and customers in more than 100 countries. OEM pulmonary function test filters, viral- Platinum 0.001" – 0.005" 0.001" – 0.005" 0.001" 1976 2016 bacterial filters, breathing circuits, and Platinum-Iridium 0.001" – 0.005" 0.002" – 0.005" — Our Neuroscience and Electrophysiology NEUROSCIENCE & 3L calibration syringes are found in Silver 0.001" – 0.025" 0.001" – 0.025" 0.001" – 0.005" Division designs, manufactures and A-M SYSTEMS hospitals and clinics around the world. distributes a wide range of scientific 40TH ANNIVERSARY Stainless Steel 0.002" – 0.020" 0.002" – 0.010" 0.001" – 0.010" ELECTROPHYSIOLOGY instruments, including stimulators, Tungsten 0.001" – 0.020" 0.002" – 0.010" 0.002" – 0.010" A-M Systems is committed to producing intracellular and extracellular amplifiers, and patch clamp and delivering innovative, high-quality products and services INSTRUMENTATION amplifiers. Leading universities and research institutions use efficiently and affordably. To learn more about how A-M Systems our instruments and accessories to perform ground-breaking can help you meet your research objectives, please contact us today.

HumBug Noise Eliminator © 2016 A-M SYSTEMS A-M Systems 131 Business Park Loop The HumBug Noise Eliminator from Quest Scientific removes Sequim, WA 98382 1976 2016 line frequency noise from electrophysiological signals without U.S.A. filtering or requiring ongoing user attention. That means more Tel.: +1.360.683.8300 A-M SYSTEMS time getting results, and less time solving continuously evolving Tel.: +1.800.426.1306 TH noise and ground loop problems. ISO 13485:2003 Fax: +1.360.683.3525 40 ANNIVERSARY WWW.A-MSYSTEMS.COM FM 509574 [email protected] Isolated High Power Stimulator MultiStim 8-Channel Programmable Stimulator & Optional SIU Patch Clamp Amplifier Model 4100 Model 3800 Model 3820 Model 2400 Microelectrode Holders

• Full-featured amplifier with voltage and current clamp modes The Model 3800 MultiStim 8-Channel Programmable Stimulator • Touch screen or computer control • Capacity, series resistance, and whole cell compensation Straight, Axon Universal Connector is a highly flexible, programmable pulse generator that can • Pulse Widths: 1 µs – 250 hours; ±10 V amplitude • Telegraph outputs for all major front panel controls with Silver Wire & Suction Port produce independent, complex pulse trains on 8 channels • Monophasic / biphasic, paired & stepped pulse protocols • Displays command potentials, cell currents, and voltages • Dual-range low-noise resistive feedback headstage (1 GΩ/10 MΩ; simultaneously. When combined with its optional SIUs, the • Combine channels for custom protocols 10 GΩ/10 MΩ; 10 GΩ/100 MΩ) Model 4100 Isolated High Power Stimulator: the new standard-bearer for stimulation instrumentation. Model 3800 can produce scaled, isolated constant current or With SIU: constant voltage pulses. • ± 60 V at 20 mA • Constant Current or Constant Voltage The Model 4100 Isolated High Power Programmable Stimulator is our most powerful, OPTOGENETICS FIELD STIMULATION BEHAVIOR • Single SIU can produce biphasic pulses flexible, and convenient single-channel stimulator. Perfect for a wide variety of INSTRUMENT SYNCHRONIZATION LESION MAKING applications, including optogenetics and field stimulation, the Model 4100 is designed to be your lab’s workhorse stimulator, delivering maximum performance at a fair price. • Complete computer control 16-Channel Extracellular AC Amplifiers Neuroprobe Intracellular Amplifier Model 3500 & Model 3600 • Line-Powered: No batteries required Model 3500 and Model 3600 Model 1600 POWERFUL ±200 V pulses at 100 mA • Internal isolation: No external SIU required • 16 independent high gain, low noise channels • Accepts arbitrary waveform inputs FLEXIBLE Monophasic, Biphasic, Ramp, & User-Defined waveforms • Control via front panel touch screen or Windows program Straight, BNC Connector with Silver Wire & Suction Port CONVENIENT Front Panel, Windows®, Apple®, LabVIEW™, MATLAB®, & Android™ compatible Software Control • Parameter sets stored on-board and/or on a PC AFFORDABLE Built-in isolator eliminates need for an additional external SIU • Built-in Output Monitors & Calibration Signal • Axon Universal, Axon Legacy, BNC, and • High Pass, Low Pass, and Notch Filters 2 mm Pin connectors The 4100 can deliver stimulus trains comprised of monophasic, biphasic, and ramped • TTL Control • Silver Wire or Silver/Silver Chloride Pellet waveforms. The 4100 can also scale and isolate any unique, custom, or biologically • Digital meter displays membrane potential, injected current, • With or without Suction Ports generated signal you can provide. Model 3600 Model 3500 or electrode resistance • Square-wave generator for electrode test and adjustment of The Model 3500 is a true differential amplifier perfect for studies • Two headstage options for use with high • True differential, common reference or • With or without Perfusion Ports The 4100 can provide pulse durations between 1 µs and 25 hours long. The 4100, with capacitance compensation such as EEG and EKG. impedance electrodes ground reference recording options its built in memory, can easily deliver traditional protocols such as LTP/LTD stimulation • Current injection system allows simultaneous stimulating • Straight, 30°, 45°, or 90° studies, Paired Pulses protocols, and Stepped Pulses with a single trigger pulse. The Model 3600 utilizes a 16-channel headstage to enable spike »» Stimulating and recording headstage • Can pass stimulation signals directly to and recording by a single electrode • Custom holders can be made to your recordings using high-impedance electrodes. »» Miniature record-only headstage electrodes design!

Isolated Pulse Stimulator Analog Stimulus Isolator Microelectrode AC Amplifier Four-Channel Differential AC Amplifier Intracellular Electrometer Audio Monitor AC/DC Amplifier Model 2100 Model 2200 Model 1800 Model 1700 Model 3100 Model 3300 Model 3000

• Pulse width from 1 µs to over 15 minutes • Constant current or constant voltage • Two independent channels • Four independent channels • Low noise • Two input channels • Differential or single-ended • Excellent timing accuracy! Better than 0.02% • Can isolate any input waveform shape • Includes two headstages • Recording gains: x100, x1,000, or x10,000 • Input impedance: 1013 Ω • 6-band frequency equalizer for recordings • Monophasic or biphasic pulse outputs • Maximum output ±50 V Biphasic (100 V monophasic), • Recording gains: x100, x1,000, or x10,000 • 2.5 µV rms noise max (10 Hz–100 kHz) • Bias current: adjustable to zero custom sound performance • DC and AC modes • Optically-isolated; No separate stimulus isolator required! or 5 mA • Low noise (2.5 µV peak-to-peak max., 10 Hz–10 kHz) • High common-mode rejection • DC balance with transient • 3 gain settings • Optional headstage for use with • TTL sync outputs, triggering & gate • Uses rechargeable batteries; charger included • High Pass, Low Pass and Notch Filters • Optional headstage available suppression circuitry • Headphone jack high-impedance electrodes • High Pass, Low Pass, Notch Filters Isolated High Power Stimulator MultiStim 8-Channel Programmable Stimulator & Optional SIU Patch Clamp Amplifier Model 4100 Model 3800 Model 3820 Model 2400 Microelectrode Holders

• Pulse width from 1 µs to over 15 minutes • Constant current or constant voltage • Two independent channels • Four independent channels • Low noise • Two input channels • Differential or single-ended • Excellent timing accuracy! Better than 0.02% • Can isolate any input waveform shape • Includes two headstages • Recording gains: x100, x1,000, or x10,000 • Input impedance: 1013 Ω • 6-band frequency equalizer for recordings • Monophasic or biphasic pulse outputs • Maximum output ±50 V Biphasic (100 V monophasic), • Recording gains: x100, x1,000, or x10,000 • 2.5 µV rms noise max (10 Hz–100 kHz) • Bias current: adjustable to zero custom sound performance • DC and AC modes • Optically-isolated; No separate stimulus isolator required! or 5 mA • Low noise (2.5 µV peak-to-peak max., 10 Hz–10 kHz) • High common-mode rejection • DC balance with transient • 3 gain settings • Optional headstage for use with • TTL sync outputs, triggering & gate • Uses rechargeable batteries; charger included • High Pass, Low Pass and Notch Filters • Optional headstage available suppression circuitry • Headphone jack high-impedance electrodes • High Pass, Low Pass, Notch Filters Bipolar Suction Electrode Optopatcher® Connectors Electrodes Capillary Glass

HumBug Noise Eliminator © 2016 A-M SYSTEMS A-M Systems 131 Business Park Loop The HumBug Noise Eliminator from Quest Scientific removes Sequim, WA 98382 1976 2016 line frequency noise from electrophysiological signals without U.S.A. filtering or requiring ongoing user attention. That means more Tel.: +1.360.683.8300 A-M SYSTEMS time getting results, and less time solving continuously evolving Tel.: +1.800.426.1306 TH noise and ground loop problems. ISO 13485:2003 Fax: +1.360.683.3525 40 ANNIVERSARY WWW.A-MSYSTEMS.COM FM 509574 [email protected] Bipolar Suction Electrode Optopatcher® Connectors Electrodes Capillary Glass