Understanding Arrhythmias and Your Electrophysiology Procedure
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General Signs and Symptoms of Abdominal Diseases
General signs and symptoms of abdominal diseases Dr. Förhécz Zsolt Semmelweis University 3rd Department of Internal Medicine Faculty of Medicine, 3rd Year 2018/2019 1st Semester • For descriptive purposes, the abdomen is divided by imaginary lines crossing at the umbilicus, forming the right upper, right lower, left upper, and left lower quadrants. • Another system divides the abdomen into nine sections. Terms for three of them are commonly used: epigastric, umbilical, and hypogastric, or suprapubic Common or Concerning Symptoms • Indigestion or anorexia • Nausea, vomiting, or hematemesis • Abdominal pain • Dysphagia and/or odynophagia • Change in bowel function • Constipation or diarrhea • Jaundice “How is your appetite?” • Anorexia, nausea, vomiting in many gastrointestinal disorders; and – also in pregnancy, – diabetic ketoacidosis, – adrenal insufficiency, – hypercalcemia, – uremia, – liver disease, – emotional states, – adverse drug reactions – Induced but without nausea in anorexia/ bulimia. • Anorexia is a loss or lack of appetite. • Some patients may not actually vomit but raise esophageal or gastric contents in the absence of nausea or retching, called regurgitation. – in esophageal narrowing from stricture or cancer; also with incompetent gastroesophageal sphincter • Ask about any vomitus or regurgitated material and inspect it yourself if possible!!!! – What color is it? – What does the vomitus smell like? – How much has there been? – Ask specifically if it contains any blood and try to determine how much? • Fecal odor – in small bowel obstruction – or gastrocolic fistula • Gastric juice is clear or mucoid. Small amounts of yellowish or greenish bile are common and have no special significance. • Brownish or blackish vomitus with a “coffee- grounds” appearance suggests blood altered by gastric acid. -
Heart Failure
Heart Failure Sandra Keavey, DHSc, PAC, DFAAPA Defined Heart failure (HF) is a common clinical syndrome resulting from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. HF may be caused by disease of the myocardium, pericardium, endocardium, heart valves, vessels, or by metabolic disorders Epidemiology-Magnitude Heart failure disproportionately affects the older population. Approximately 80% of all cases of heart failure in the United States occur in persons aged 65 years and older. In the older population, heart failure accounts for more hospital admissions than any other single condition. Following hospitalization for heart failure, nearly half are readmitted within 6 months. Epidemiology-Prevalence Prevalence. About 5.1 million people in the United States have heart failure. One in 9 deaths in 2009 included heart failure as contributing cause. About half of people who develop heart failure die within 5 years of diagnosis. 25% of all heart failure patients are re-admitted to the hospital within 30 days. 50% of all heart failure patients are re-admitted to the hospital within 6 months. Systolic vs Diastolic There are two common types of heart failure Systolic HF Systolic HF is the most common type of HF Now referred to as HFrEF Heart Failure reduced Ejection Fraction The heart is weak and enlarged. The muscle of the left ventricle loses some of its ability to contract or shorten. Diastolic HF Diastolic HF is not an isolated disorder of diastole; there are widespread abnormalities of both systolic and diastolic function that become more apparent with exercise. -
Electrophysiology-Appnote.Pdf
Application Note: Electrophysiology Electrophysiology Introduction Electrophysiology is a field of research that deals with the electrical properties of cells and biological tissues. In some cases, it is used to test for nervous or cardiac diseases and abnormalities. In many research applications probes are used to measure the electrical activity of individual cells, tissues, and whole specimens. Measuring the activity of cells at various membrane potentials can give valuable information about ion transport mechanisms and cellular communication. Varying ionic strength and membrane potential on cell populations can be used to study contractile movements of muscle cells, and diseases affecting the normal propagation of impulses. Using various stimulation techniques along with a selection of quality equipment and setup design can give rise to a wealth of applications in electrophysiology. Electrophysiology Principle Researchers and clinicians use electrophysiology when studying the electrical properties of neural and muscle tissue. In the clinical laboratory, electroencephalograms are routinely performed as a test for neural disorders like epilepsy, brain tumor, stroke, encephalitis, and others by measuring the electrical activity of the brain through external electrodes. In the research laboratory, electrophysiology methods are used to measure the ion-channel activity of cell membranes in various electrical environments. Here, an extremely thin micropipette is used to make intimate contact with the cell membrane to study membrane potential. Neurons and other cell types derive their electrical properties from their lipid bilayer and the ion concentrations inside and outside of the cell. The ion concentration differences create a membrane potential difference on either side of the membrane. The flow of ions across the membrane generates a current that can be measured using Ohm’s law, where the change in voltage (V) is related to the current (I) and membrane resistance (R). -
Brain Slice Preparation in Electrophysiology
Brain Slice Preparation In structural integrity, unlike cell cultures or tissue homogenates. Electrophysiology Some of the limitations of these preparations are: 1) lack of certain inputs and outputs normally existing in the Avital Schurr, Ph.D. intact brain; 2) certain portions of the sliced tissue, Department of Anesthesiology, especially the top and bottom surfaces of the slice, are University of Louisville School of Medicine, damaged by the slicing action itself; 3) the life span of a Louisville, Kentucky 40292 brain slice is limited and the tissue gets "older" at a much faster rate than the whole animal; 4) the effects of Avital Schurr is currently an Associate Professor in the decapitation ischemia on the viability of the slice are not Department of Anesthesiology at the University of well understood; 5) Since blood-borne factors may be Louisville. He received his Ph.D. in 1977 from Ben- missing from the artificial bathing medium of the brain Gurion University in Beer Sheva, Israel. From 1977 slice, they cannot benefit the preparation and thus the through 1981, he held two postdoctoral positions, one optimal composition of the bathing solution is not yet at the Baylor College of Medicine and the second at established. the University of Texas Medical School at Houston. Brain slice preparations are becoming PREPARATION OF SLICES increasingly popular among neurobiologists for the In general, rodents are the animals of choice for the study of the mammalian central nervous system preparation of brain slices. Of those, the rat and the guinea pig are the most used. After decapitation, the (CNS) in general and synaptic phenomena in brain is removed rapidly from the skull and rinsed with particular. -
Medical Terminology Abbreviations Medical Terminology Abbreviations
34 MEDICAL TERMINOLOGY ABBREVIATIONS MEDICAL TERMINOLOGY ABBREVIATIONS The following list contains some of the most common abbreviations found in medical records. Please note that in medical terminology, the capitalization of letters bears significance as to the meaning of certain terms, and is often used to distinguish terms with similar acronyms. @—at A & P—anatomy and physiology ab—abortion abd—abdominal ABG—arterial blood gas a.c.—before meals ac & cl—acetest and clinitest ACLS—advanced cardiac life support AD—right ear ADL—activities of daily living ad lib—as desired adm—admission afeb—afebrile, no fever AFB—acid-fast bacillus AKA—above the knee alb—albumin alt dieb—alternate days (every other day) am—morning AMA—against medical advice amal—amalgam amb—ambulate, walk AMI—acute myocardial infarction amt—amount ANS—automatic nervous system ant—anterior AOx3—alert and oriented to person, time, and place Ap—apical AP—apical pulse approx—approximately aq—aqueous ARDS—acute respiratory distress syndrome AS—left ear ASA—aspirin asap (ASAP)—as soon as possible as tol—as tolerated ATD—admission, transfer, discharge AU—both ears Ax—axillary BE—barium enema bid—twice a day bil, bilateral—both sides BK—below knee BKA—below the knee amputation bl—blood bl wk—blood work BLS—basic life support BM—bowel movement BOW—bag of waters B/P—blood pressure bpm—beats per minute BR—bed rest MEDICAL TERMINOLOGY ABBREVIATIONS 35 BRP—bathroom privileges BS—breath sounds BSI—body substance isolation BSO—bilateral salpingo-oophorectomy BUN—blood, urea, nitrogen -
Study Guide Medical Terminology by Thea Liza Batan About the Author
Study Guide Medical Terminology By Thea Liza Batan About the Author Thea Liza Batan earned a Master of Science in Nursing Administration in 2007 from Xavier University in Cincinnati, Ohio. She has worked as a staff nurse, nurse instructor, and level department head. She currently works as a simulation coordinator and a free- lance writer specializing in nursing and healthcare. All terms mentioned in this text that are known to be trademarks or service marks have been appropriately capitalized. Use of a term in this text shouldn’t be regarded as affecting the validity of any trademark or service mark. Copyright © 2017 by Penn Foster, Inc. All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the copyright owner. Requests for permission to make copies of any part of the work should be mailed to Copyright Permissions, Penn Foster, 925 Oak Street, Scranton, Pennsylvania 18515. Printed in the United States of America CONTENTS INSTRUCTIONS 1 READING ASSIGNMENTS 3 LESSON 1: THE FUNDAMENTALS OF MEDICAL TERMINOLOGY 5 LESSON 2: DIAGNOSIS, INTERVENTION, AND HUMAN BODY TERMS 28 LESSON 3: MUSCULOSKELETAL, CIRCULATORY, AND RESPIRATORY SYSTEM TERMS 44 LESSON 4: DIGESTIVE, URINARY, AND REPRODUCTIVE SYSTEM TERMS 69 LESSON 5: INTEGUMENTARY, NERVOUS, AND ENDOCRINE S YSTEM TERMS 96 SELF-CHECK ANSWERS 134 © PENN FOSTER, INC. 2017 MEDICAL TERMINOLOGY PAGE III Contents INSTRUCTIONS INTRODUCTION Welcome to your course on medical terminology. You’re taking this course because you’re most likely interested in pursuing a health and science career, which entails proficiencyincommunicatingwithhealthcareprofessionalssuchasphysicians,nurses, or dentists. -
Signs and Symptoms
Signs and Symptoms Some abnormal heart rhythms can happen without the person knowing it, while some may cause a feeling of the heart “racing,” lightheadedness, or dizziness. At some point in life, many adults Rapid Heartbeat – Tachycardia have had short-lived heart rhythm When the heart beats too quickly changes that are not serious. (usually above 100 beats per minute), the lower chambers, or Certain heart rhythms, especially ventricles, do not have enough time those that last long enough to af - to fill with blood, so they cannot ef - fect the heart’s function, can be fectively pump blood to the rest of serious or even deadly. the body. When this happens, some Palpitation or Skipped Beat people have symptoms such as: Although it may seem as if the Skipping a beat Slow Heartbeat – Bradycardia heart missed a beat, it has really had an early heartbeat — an extra If the heartbeat is too slow (usually Beating out of rhythm below 60 beats per minute), not beat that happens before the heart Palpitations has a chance to fill with blood. enough blood carrying oxygen Fast or racing heartbeat Therefore the squeeze is empty flows through the body. The symptoms of a slow heartbeat are: and results in a pause. Shortness of breath Fatigue (feeling tired) Fluttering Chest pain A fluttering sensation (like butter - Dizziness Dizziness flies in the chest) is usually due to Lightheadedness extra or “skipped beats” that occur Lightheadedness Fainting or near fainting one right after the other, or may be Fainting or near fainting caused by other kinds of abnormal heart rhythms. -
Arrhythmia What Is It?
Arrhythmia What is it? Most of us have felt our heart race or skip a beat. It’s fairly normal every once and a while. But for some people, it’s a sign of arrhythmia – a disorder of your heart rate or rhythm – that needs to be checked out by a specialist. If you have an arrhythmia (there are multiple types), your heart either beats: • too fast • too slow or • with an irregular pattern Did You Know? This change in your heart rhythm is usually caused by a “glitch” Our heart beats an average of in your heart’s electrical activity, which tells the heart when to 70 to 80 times a minute and contract and pump blood to the body. Your heart doesn’t beat over 100,000 times a day! It’s with the regularity of a Swiss watch, and many factors can cause no wonder millions of people an irregularity. notice palpitations such as skipping a beat, fluttering or a Some of these factors include: racing heart. • having had a heart attack • having heart failure • blood chemistry imbalances • abnormal hormone levels • alcohol, caffeine and other substances or medicines • a variety of inherited abnormalities 8 Tips for Staying Heart Healthy with Arrhythmias Living with an arrhythmia varies tremendously from one person to the next. It will depend on the type of arrhythmia you have, how serious it is and the recommended treatment. Some people can take a single medication to correct their heart’s rhythm; others undergo electrophysiology studies or require a pacemaker or implantable defibrillator. No matter what kind of arrhythmia you have, there are things you can do to keep your heart healthy and ticking as it should. -
GE Reflux Presentations, Complications, and Treatment
GE Reflux Presentations, Complications, and Treatment Osama Almadhoun, MD Chief, UBMD Pediatric Gastroenterology Associate Professor, University at Buffalo Learning Objectives • Understand the difference between GER and GERD • To review the signs and symptoms related to GERD • Discuss the diagnostic and therapeutic management of GER. • Learn about indications and potential complications of Fundoplication. • Understand literature and management dilemmas for Extra- Esophageal manifestations of GER(D) GER • Passage of gastric contents into the esophagus. – Normal physiologic process, last <3 minutes. – Occur in the postprandial period and cause few or no symptoms. • Normal COMMON!!!phase in the development in infants and toddlers – 50% of infants in the first 3 mos of life – 67% of 4 month old infants – 5% of 10 to 12 month old infants. • Happy “Spitters” • No evaluation or testing is necessary Nelson et al, 1997 GERD GERD is present when the reflux of gastric contents causes troublesome symptoms and/or complications. Refractory GERD . GERD not responding to optimal treatment after 8 weeks. Regurgitation: The passage of refluxed gastric contents into the oral pharynx. Vomiting: Expulsion of the refluxed gastric contents from the mouth. Proportion (%) of children who spilled. A James Martin et al. Pediatrics 2002;109:1061-1067 Reflux Mechanism Intragastric pressure overcomes the opposition of the high- pressure zone at the distal end of the esophagus: • LES tone • Diaphragmatic crura • Intraabdominal portion of the esophagus • Angle of His Dent J et al, J Clin Invest, 1980 Mittal, R. K. et al. N Engl J Med 1997;336:924-932 Pathogenesis • Primary Mechanism • Transient lower esophageal sphincter relaxations (TLESRs) • Decrease basal LES tone GER and impaired esophageal acid clearance • Secondary Mechanism • Overfeeding, Overweight • Increased intra-abdominal pressure • Delayed Gastric Emptying • There are a number of challenges to defining GER and GERD in the pediatric population. -
Electrophysiology Read-Out Tools for Brain-On-Chip Biotechnology
micromachines Review Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology Csaba Forro 1,2,†, Davide Caron 3,† , Gian Nicola Angotzi 4,†, Vincenzo Gallo 3, Luca Berdondini 4 , Francesca Santoro 1 , Gemma Palazzolo 3,* and Gabriella Panuccio 3,* 1 Tissue Electronics, Fondazione Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci, 53-80125 Naples, Italy; [email protected] (C.F.); [email protected] (F.S.) 2 Department of Chemistry, Stanford University, Stanford, CA 94305, USA 3 Enhanced Regenerative Medicine, Fondazione Istituto Italiano di Tecnologia, Via Morego, 30-16163 Genova, Italy; [email protected] (D.C.); [email protected] (V.G.) 4 Microtechnology for Neuroelectronics, Fondazione Istituto Italiano di Tecnologia, Via Morego, 30-16163 Genova, Italy; [email protected] (G.N.A.); [email protected] (L.B.) * Correspondence: [email protected] (G.P.); [email protected] (G.P.); Tel.: +39-010-2896-884 (G.P.); +39-010-2896-493 (G.P.) † These authors contributed equally to this paper. Abstract: Brain-on-Chip (BoC) biotechnology is emerging as a promising tool for biomedical and pharmaceutical research applied to the neurosciences. At the convergence between lab-on-chip and cell biology, BoC couples in vitro three-dimensional brain-like systems to an engineered microfluidics platform designed to provide an in vivo-like extrinsic microenvironment with the aim of replicating tissue- or organ-level physiological functions. BoC therefore offers the advantage of an in vitro repro- duction of brain structures that is more faithful to the native correlate than what is obtained with conventional cell culture techniques. -
Electrophysiology Study
Electrophysiology (EP) Study Highly trained specialists perform EP studies in a specially designed EP lab outfitted with advanced technology and equipment. Why an EP study? The Value of an EP Study While electrocardiograms (ECGs An electrophysiology, or EP, study or EKGs) are important tests of the provides information that is key to heart’s electrical system, they diagnosing and treating arrhythmias. provide only a brief snapshot of Although it is more invasive than an the heart’s electrical activity. electrocardiogram (ECG) or echocar - Arrhythmias can be unpredictable diogram, and involves provoking and intermittent, which makes it arrhythmias, the test produces data unlikely that an electrocardiogram that makes it possible to : will capture the underlying electri - Normally, electricity flows through - cal pathway problem. Even tests • Diagnose the source of arrhythmia out the heart in a regular, meas - that stretch over longer time periods , symptoms such as Holter monitoring, may not ured pattern. This electrical system • Evaluate the effectiveness of capture an event. brings about coordinated heart certain medications in controlling muscle contractions. A problem During an EP study, a specially the heart rhythm disorder anywhere along the electrical trained cardiac specialist may pro - • Predict the risk of a future cardiac pathway causes an arrhythmia, voke arrhythmia events and collect event, such as Sudden Cardiac or heart rhythm disturbance. By data about the flow of electricity Death accurately diagnosing the precise during actual events. As a result, cause of an arrhythmia, it is possi - • Assess the need for an implantable EP studies can diagnose the ble to select the best possible device (a pacemaker or ICD) or cause and precise location of the treatment. -
Clinical Assessment in Acute Heart Failure
Hellenic J Cardiol 2015; 56: 285-301 Review Article Clinical Assessment in Acute Heart Failure 1 2 NIKOLAOS S. KAKOUROS , STAVROS N. KAKOUROS 1University of Massachusetts, MA, USA; 2Cardiac Department, “Amalia Fleming” General Hospital, Athens, Greece Key words: eart failure (HF) is defined as “a clear precipitant or trigger. It is very im Heart failure, complex clinical syn drome that portant to establish the precipitating diagnosis, physical examination, H can result from any structural or causes, which may have therapeutic and congestion. functional cardiac disorder that impairs the prognostic implications. Approximate ability of the ventricle to fill with, or eject ly 60% of patients with AHF have doc blood.” HF has an estimated overall prev umented CAD. Myocardial ischemia in alence of 2.6%. It is becoming more com the setting of acute coronary syndromes mon in adults older than 65 years, because is a precipitant or cause, particularly in of increased survival after acute myocar patients presenting with de novo AHF.4 dial infarction (AMI) and improved treat AHF is also often precipitated by medica ment of coronary artery disease (CAD), tion and dietary noncompliance, as well val vular heart disease and hypertension.1 as by many other conditions, which are Acute HF (AHF) is an increasingly com summarized in Table 1. Once the diagno mon cause of hospitalizations and mortality sis of AHF is confirmed, initial therapy in worldwide. In the majority of patients, AHF cludes removal of precipitants; if this can Manuscript received: can be attributed to worsening chronic HF, be carried out successfully, the patient’s August 25, 2014; and approximately 4050% of this group have subsequent course may be stable.