ANNEXURE – R RISK ASSESSMENT REPORT
FOR
PROPOSED CHANGE IN PRODUCT MIX FOR BULK DRUGS AND INTERMEDIATES MANUFACTURING UNIT AT
Polt No. 285, 286 & 287, KIADB Industrial Area, Bommasandra-Jigani Link Road, Phase-IV TALUK: ANEKAL DISTRICT: BENGALURU, URBAN STATE: KARNATAKA BY M/s. CIPLA Limited
[Project termed under schedule 5(f): Category ‘B’ Synthetic organic chemicals.
ToR videfile no. SEIAA 33 IND 2016, dated: 24th Sep, 2016.
Report Prepared by
(NABET Accredited vide Certificate No. NABET/EIA/1619/RA0083 &MoEF Recognized Lab vide F. No. Q-15018/13/2016-CPW) HUBERT ENVIRO CARE SYSTEMS (P) LTD, CHENNAI
APRIL, 2018
1 TABLE OF CONTENTS
ABBREVIATIONS ...... 4 1 INTRODUCTION ...... 5 1.1 Purpose of the report...... 5 1.2 Scope of the study...... 5 1.3 Methodology adopted ...... 6 1.4 Risk Analysis ...... 6
2 RISK ASSESSMENT METHODOLOGY...... 9 2.1 Identification of Hazards & Release Scenarios...... 9 2.1.4 Factors considered for identification of hazards ...... 11
3 CONSEQUENCE ANALYSIS...... 17 3.1 Scenarios possible...... 17 3.2 Weather probabilities...... 17 3.2.1 Wind velocity & Stability class ...... 17
3.2.2 Weather input...... 18
3.3 Fire Hazards and Risk Mitigation Plan ...... 19
3.3.1 Fire Hazards...... 19
3.4 SUMMARY & OBSERVATIONS ...... 45
3.5 Risk control measures ...... 45
4 MITIGATIVE MEASURES...... 47 4.1 Summary of risk analysis and findings...... 47 4.2 Recommendations for improving safety...... 47 5 EMERGENCY PLAN ...... 48 5.1 Objectives ...... 48 5.2 Basic forms of Emergency...... 48 5.3 Types of Emergency ...... 48 5.4 Causes of Emergency...... 49 5.5 Safety, Health & Environment Policy...... 49 5.6 Mitigation Measures Required...... 50 5.7 Emergency Shutting Down Procedure...... 50
2 5.8 Control Room...... 51 5.9 Alert Action Plan during Working &Non Working Hours...... 51 5.10 On Site Emergency Planning ...... 53 5.11 Offsite Emergency Plan ...... 60 5.11.1 Preamble ...... 60 5.11.2 Objective...... 60 5.11.3 Offsite Emergency Control ...... 60 5.11.4 Emergency Instruction to the General Public ...... 61 5.11.5 Category of Alarm Systems ...... 61 5.11.6 Fire Fighting System...... 62 5.11.7 General Instruction to the Public...... 62 5.11.8 Security & Police ...... 63
LIST OF TABLES Table 2-1 NFPA Classification...... 11 Table 2-2 List of Chemicals used with properties ...... 12 Table 2-3 Damages to Human Life Due to Heat Radiation...... 14 Table 2-4 Effects Due To Incident Radiation Intensity ...... 15 Table 3-1 Pasquill – Giffard Atmospheric Stability ...... 17 Table 3-2 Atmospheric data (Manual Input for the worst scenario)...... 18 Table 3-3 Solvent tank details...... 19 Table 3-4 Chemical flowing from Storage tank pipeline details ...... 20 Table 3-5: Estimated distance due to failure of Storage tank pipeline...... 21
LIST OF FIGURES Figure 1-1 Plant Layout ...... 7 Figure 3-1 Toxic area of vapour cloud from rupture of Methanol Storage tank Pipeline...... 23 Figure 3-2 Jet fire from rupture of Methanol Storage tank Pipeline...... 24 Figure 3-3 Pool fire from rupture of Methanol Storage tank Pipeline...... 25 Figure 3-4 Flash fire from rupture of Methanol Storage tank Pipeline...... 26 Figure 3-5 Toxic area of vapour cloud from rupture of Isopropyl alcohol Storage tank Pipeline...... 27 Figure 3-6 Jet fire from rupture of Isopropyl alcohol Storage tank Pipeline ...... 28 Figure 3-7 Pool fire from rupture of Isopropyl alcohol Storage tank Pipeline ...... 29 Figure 3-8 Flash fire from rupture of Isopropyl alcohol Storage tank Pipeline...... 30 Figure 3-9 Toxic area of vapour cloud from rupture of Hexane Storage tank Pipeline...... 31 Figure 3-10 Jet fire from rupture of Hexane Storage tank Pipeline...... 32 Figure 3-11 Pool fire from rupture of Hexane Storage tank Pipeline ...... 33 Figure 3-12 Flash fire from rupture of Hexane Storage tank Pipeline...... 34
3 Figure 3-13 Late Explosion worst case radii from rupture of Hexane Storage tank Pipeline...... 35 Figure 3-14 Toxic area of vapour cloud from rupture of Acetone Storage tank Pipeline...... 36 Figure 3-15 Jet fire from rupture of Acetone Storage tank Pipeline...... 37 Figure 3-16 Pool fire from rupture of Acetone Storage tank Pipeline...... 38 Figure 3-17 Flash fire from rupture of Acetone Storage tank Pipeline...... 39 Figure 3-18 Late Explosion worst case radii from rupture of Acetone Storage tank Pipeline...... 40 Figure 3-19 Toxic area of vapour cloud from rupture of Toluene Storage tank Pipeline...... 41 Figure 3-20 Jet fire from rupture of Toluene Storage tank Pipeline ...... 42 Figure 3-21 Pool fire from rupture of Toluene Storage tank Pipeline ...... 43 Figure 3-22 Flash fire from rupture of Toluene Storage tank Pipeline...... 44
ABBREVIATIONS
MDC Methylene Di Chloride
API Active Pharmaceutical Ingredients KIADB Karnataka Industrial Areas Development Board ALARP As Low As Reasonably Practical BLEVE Boiling Liquid Expanding Vapor Explosion
TNO Thai National Observatory VCE Vapor Cloud Explosion NFPA National Fire Protection Agency LFL Lower Flammability Limit AAQ Ambient Air Quality
4 1 INTRODUCTION
1.1 Purpose of the report The purpose of the study is to identify and assess those hazards and risks arising from proposed project “Proposed change in product mix for bulk drugs and intermediates manufacturing unit” by M/s. Cipla Limited, at Anekal Taluk, Bangalore District and Karnataka state. Based on the available studies & plant layout, the potential scenarios which can cause significant consequences like fire and explosion scenarios were identified. The purpose of the study includes the following: To identify and assess those hazards and risks with NFPA rating. To eliminate or reduce to As Low As Reasonably Practical (ALARP) in terms of risk to human health, risk of injury, risk of damage to plant, equipment and environment, business interruption or loss etc., To Suggest On-site and Off-site mitigative Measures.
1.2 Scope of the study Hazard Identification and Risk Analysis including identification, screening of scenarios, consequence analysis of the various risk scenarios, recommendation and preparation of reports and relevant drawing showing damage and risk contours. The scope of the study mainly involves: Identifications of Hazards Consequence modelling Vapour cloud Flash fire Pool fire Jet fire Impact limits identifications Contour mapping of the risk on the layouts. Mitigating measures for handling and storage to reduce impacts & prevent incidents.
5 1.3 Methodology adopted The Risk Assessment has been carried out by using the ALOHA software 5.4.5 (Aerial Locations of Hazardous Atmospheres) which was developed by office of Emergency management, EPA and Emergency Response Division, NOAA & PHAST Lite 7.11 (Licence number 1603- 120331(S-28502)) developed by DNV GL AS 2014.
1.4 Risk Analysis
According to the specific items 7 and xiv of the Terms of Reference (ToR) issued for the project, preliminary hazard identification and risk assessment was undertaken to quantify the possible fire and occupational health risks associated with the operation of the project at the designated location. The good engineering practices suggested by the Central Pollution Control Board (CPCB) for risk assessment in industries (CPCB document Probes/133/2009-10) and CPR-18 E risk assessment procedures guidelines which are widely accepted by the Ministry of Environment, Forests & Climate Change (MoEF & CC) India, have been adopted while assessing the residual risks associated with the operations of the project with specific reference to fire hazards, chemical exposure hazards, occupational hazards and natural hazards.
As part of the risk assessment, a preliminary review on the hazardous materials and chemicals proposed to be handled at the site were reviewed and the storage capacities and design features of such hazardous materials were also reviewed while assessing the residual risks. Qualitative analysis of risks associated with natural hazards such as earth quakes, floods and cyclones were also undertaken.
Based on the findings of the risk assessment study, a preliminary risk management plan has been developed as per the applicable rules and guidelines; where ever possible, good engineering and management practices are suggested to minimize any intolerable risks.
6 1.5 Basic Facilities details The plant layout is shown below
Figure 1-1 Plant Layout
7 1.6 Storage tank details
S.No Chemical No. of Dia Height Volume Internal Type of storage Internal Temp Tanks Pressure
(m) (m) (KL) (0c) 1 Methanol 1 2.5 6.5 25 Under Underground Ambient
2 IPA 1 2.5 6.5 25 Nitrogen tank kept in Temp blanketing at RCC tank and 3 Hexane 1 2.5 6.5 25 50 mili bar submerged in 4 Ethyl 1 2.5 6.5 25 Gravel Acetate 5 Acetone 1 2.5 6.5 25
6 Toluene 1 2.5 6.5 25 7 HSD 1 3 3 40 Atmospheric Above Ground
8 Furnace oil 1 3 4 20 Pressure
9 Methylene 1 2 4 15 Under
10 Chloroform 1 2 4 15 Nitrogen blanketing at 50 mili bar
1.7 Pipeline details
S.No Pipe Pipeline Pipeline Operating No./Name Size dia length (m) Temperature (m) (oC) 1 Methanol 0.051 200 35 Isopropyl 2 0.051 200 35 alcohol
3 Hexane 0.051 200 35
4 Acetone 0.051 200 35
5 Toluene 0.051 200 35
8 2 RISK ASSESSMENT METHODOLOGY
2.1 Identification of Hazards & Release Scenarios A technique commonly used to generate an incident list is to consider potential leaks, ruptures and fractures of all process pipelines and vessels/tanks. The following data were collected to envisage scenarios: Solvent Tank conditions (phase, temperature, pressure) and dimensions. Pipelines connected from storage tank to process tank
2.1.1 Selection The goal of selection is to limit the total number of incident outcome cases to be studied to a manageable size. The purpose of incident outcome selection is to develop a set of incident outcomes that must be studied for each incident included in the finalized incident study list. Each incident needs to be considered separately. Using the list of incident outcomes the risk analyst needs to determine which may result from each incident. While the analyst can decide whether an incident involving the loss of a process chemical to the atmosphere needs to be examined using dispersion analysis because of potential toxic gas effects, what happens if the same material is immediately ignited on release.
2.1.2 Characterizing the Failures Accidental release of flammable or toxic vapors can result in severe consequences. Delayed ignition of flammable vapors can result in blast overpressures covering large areas. This may lead to extensive loss of life and property. Toxic clouds may cover yet larger distances due to the lower threshold values in relation to those in case of explosive clouds (the lower explosive limits). In contrast, fires have localized consequences. Fires can be put out or contained in most cases; there are few mitigating actions one can take once a vapor cloud gets released. Major accident hazards arise, therefore, consequent upon the release of flammable or toxic vapors or BLEVE in case of pressurized liquefied gases. In an industry, main hazard arises due to storage and handling of hazardous chemicals. To formulate a structured approach to identification of hazards and understanding of contributory factors is essential.
9 2.1.3 Inventory Inventory Analysis is commonly used in understanding the relative hazards and short listing of release scenarios. Inventory plays an important role in regard to the potential hazard. Larger the inventory of a vessel or a system, larger the quantity of potential release. A practice commonly used to generate an incident list is to consider potential leaks and major releases from fractures of pipelines and vessels containing sizable inventories. The potential vapor release (source strength) depends upon the quantity of liquid release, the properties of the materials and the operating conditions (pressure, temperature). If all these influencing parameters are combined into a matrix and vapor source strength computed for each release case, a ranking should become a credible exercise.
Loss of Containment Liquid Release may be instantaneous. Failure of a vessel leading to an instantaneous outflow assumes the sudden appearance of such a major crack that practically all of the contents above the crack shall be released in a very short time.
The more likely event is the case of liquid release from a hole in a pipe connected to the vessel. The flow rate will depend on the size of the hole as well as on the pressure in front of the hole, prior to the accident. Such pressure is basically dependent on the pressure in the vessel.
The vaporization of released liquid depends on the vapor pressure and weather conditions. Such consideration and others have been kept in mind both during the initial listing as well as during the short listing procedure. Initial listing of all significant inventories in the process plants was carried out. This ensured no omission through in advertence.
10 2.1.4 Factors considered for identification of hazards In any installation, main hazard arises due to loss of containment during handling of flammable and toxic chemicals. The Chemicals are classified according to the properties and hazard class given by National Fire Protection Association (NFPA) is responsible for 380 codes and standards that are designed to minimize the risk and effects of fire by establishing criteria for building, processing, design, service and installation. NFPA classification (Table 2-1) for Health, Flammability & Reactivity of a chemical is on a scale from 0-4 least to worst. As per the NFPA Rating on the scale from 0-4 the chemicals having 3 & 4 are considered are highly hazardous and considered for analysis.
Table 2-1 NFPA Classification
Health Fire 0-No hazard 0-will not burn 1-can cause significant irritation 1- must be preheated before ignition occur 2-can cause temporary incapacitation or 2-must be heated or high ambient temperature residual injury to burn 3-can cause serious or permanent injury 3- can be ignited under almost all ambient 4-can be lethal 4-will vaporize and readily burn at normal temp
NFPA provides standard for the chemicals to reduce the risk of fire and other hazards which are mentioned in Table 2-2.
11 Table 2-2 List of Chemicals used with properties S.No Chemical NFPA Rating
Fire Health Stability 1 Methanol 3 1 0
2 IPA 3 1 0
3 Hexane 3 1 0
4 Ethyl Acetate 3 1 0
5 Acetone 3 1 0
6 Toluene 3 2 0 7 HSD 2 0 0
8 Furnace oil 2 2 0
9 Methylene 1 2 0
10 Chloroform 0 2 0
The fire hazard is observed in chemicals such as Methanol, Isopropyl alcohol, Hexane, Ethyl acetate, Acetone and Toluene. The health hazard is not observed in the chemicals.
2.2 Types of outcome events In this section of the report we describe the probabilities associated with the sequence of occurrences which must take place for the incident scenarios to produce hazardous effects and the modelling of their effects. Considering the present case the outcomes expected are - Jet fire - Flash Fire - Vapour Cloud - Pool Fire
12 Jet fire Jet fire occurs when a pressurized release (of a flammable gas or vapour) is ignited by any source. They tend to be localized in effect and are mainly of concern in establishing the potential for domino effects and employee safety zones rather than for community risks. The jet fire model is based on the radiant fraction of total combustion energy, which is assumed to arise from a point slowly along the jet flame path. The jet dispersion model gives the jet flame length.
Flash fire A flash fire is the non-explosive combustion of a vapour cloud resulting from a release of flammable material into the open air, which after mixing with air, ignites. A flash fire results from the ignition of a released flammable cloud in which there is essentially no increase in combustion rate. The ignition source could be electric spark, a hot surface, and friction between moving parts of a machine or an open fire. Part of the reason for flash fires is that, flammable fuels have a vapour temperature, which is less than the ambient Temperature. Hence, as a result of a spill, they are dispersed initially by the negative buoyancy of cold vapors and subsequently by the atmospheric turbulence. After the release and dispersion of the flammable fuel the resulting vapour cloud is ignited and when the fuel vapour is not mixed with sufficient air prior to ignition, it results in diffusion fire burning. Therefore the rate at which the fuel vapour and air are mixed together during combustion determines the rate of burning in the flash fire. The main dangers of flash fires are radiation and direct flame contact. The size of the flammable cloud determines the area of possible direct flame contact effects. Radiation effects on a target depend on several factors including its distance from the flames, flame height, flame emissive power, local atmospheric transitivity and cloud size.
Vapour cloud Vapour cloud is the result of flammable materials in the atmosphere, a subsequent dispersion phase, and after some delay an ignition of the vapour cloud. Turbulence is the governing factor in blast generation, which could intensify combustion to the level that will result in an explosion. Obstacles in the path of vapour cloud or when the cloud finds a
13 confined area, as under the bullets, often create turbulence. Insignificant level of confinement will result in a flash fire. The vapour cloud will result in overpressures. It may be noted that vapour cloud have been responsible for very serious accidents involving severe property damage and loss of lives.
Pool fire This represents a situation when flammable liquid spillage forms a pool over a liquid or solid surface and gets ignited. Flammable liquids can be involved in pool fires where they are stored and transported in bulk quantities. Early pool fire was caused when the steady state is reached between the outflow of flammable material from the container and complete combustion of the flammable material when the ignition source is available. Late pool fires are associated with the difference between the release of material and the complete combustion of the material simultaneously. Late pool fires are common when large quantity of flammable material is released within short time.
2.3 Heat Radiation The effect of fire on a human being is in the form of burns. There are three categories of burn such as first degree, second degree and third degree burns. The consequences caused by exposure to heat radiation are a function of: The radiation energy onto the human body [kW/m2]; The exposure duration [sec]; The protection of the skin tissue (clothed or naked body). The limits for 1% of the exposed people to be killed due to heat radiation, and for second- degree burns are given in the table below: Table 2-3 Damages to Human Life Due to Heat Radiation Radiation energy Radiation energy for Radiation energy for Exposure Duration (1% lethality, 2nd degree burns, first degree burns, kW/m2) kW/m2 kW/m2 10 sec 21.2 16 12.5 30 sec 9.3 7 4
14 Table 2-4 Effects Due To Incident Radiation Intensity TYPE OF DAMAGE 0.7 Equivalent to Solar Radiation
1.6 No discomfort for long exposure Sufficient to cause pain within 20 sec. Blistering of skin (first 4.0 degree burns are likely) Pain threshold reached after 8 sec. second degree burns after 9.5 20 sec. Minimum energy required for piloted ignition of wood, 12.5 melting plastic tubing’s etc. 37.5 Heavy Damage to process equipment
Type of damage The actual results would be less severe due to the various assumptions made in the models arising out of the flame geometry, emissivity, angle of incidence, view factor and others. The radiative output of the flame would be dependent upon the fire size, extent of mixing with air and the flame temperature. Some fraction of the radiation is absorbed by carbon dioxide and water vapour in the intervening atmosphere. Finally the incident flux at an observer location would depend upon the radiation view factor, which is a function of the distance from the flame surface, the observer’s orientation and the flame geometry. Assumptions made for the study The lethality of a jet fire is assumed to be 100% for the people who are caught in the flame. Outside the flame area, the lethality depends on the heat radiation distances. For the flash fires lethality is taken as 100% for all the people caught outdoors and for 10% who are indoors within the flammable cloud. No fatality has been assumed outside the flash fire area.
Explosion In case of vapour cloud explosion, two physical effects may occur:
15 1. A flash fire over the whole length of the explosive gas cloud; 2. A blast wave, with typical peak overpressures circular around ignition source. For the blast wave, the lethality criterion is based on: A peak overpressure of 0.1bar will cause serious damage to 10% of the housing/structures. Falling fragments will kill one of each eight persons in the destroyed buildings.
The following damage criteria may be distinguished with respect to the peak overpressures resulting from a blast wave:
Peak Overpressure Damage Type Description Major damage to plant equipment 0.30 bar Heavy Damage structure Repairable damage to plant 0.10 bar Moderate Damage equipment & structure 0.03 bar Significant Damage Shattering of glass 0.01 bar Minor Damage Crack in glass
Assumptions for the study Overpressure more than 0.3 bar corresponds approximately with 50% lethality. An overpressure above 0.2 bar would result in 10% fatalities. An overpressure less than 0.1 bar would not cause any fatalities to the public. 100% lethality is assumed for all people who are present within the cloud proper.
16 3 CONSEQUENCE ANALYSIS
3.1 Scenarios possible As large number of failure cases can lead to the same type of consequences, representative failure cases are selected for this analysis. The failure cases are based on conservative assumptions. Typically, failure models considered 100% catastrophic rupture of tanks. The scenarios are discussed one at a time.
3.2 Weather probabilities 3.2.1 Wind velocity & Stability class As per CPR 18E there are 6 representative weather classes:
Table 3-1 Pasquill – Giffard Atmospheric Stability S.No. Stability Class Weather Conditions 1 A Very unstable - Sunny, light wind 2 A/B Unstable - as with A only less sunny or more windy 3 B Unstable - as with A/B only less sunny or more windy 4 B/C Moderately unstable – moderate sunny and moderate wind 5 C Moderately unstable – very windy / sunny or overcast / light wind 6 C/D Moderate unstable – moderate sun and high wind 7 D Neutral – little sun and high wind or overcast / windy night 8 E Moderately stable – less overcast and less windy night 9 F Stable – night with moderate clouds and light / moderate wind 10 G Very stable – possibly fog
17 3.2.2 Weather input
Table 3-2 Atmospheric data (Manual Input for the worst scenario) Weather Conditions Moderate Worst Case Average Wind speed (m/s) 1.5 5 Stability Class D and F D Wind Direction West to East Temperature 38.9°C
Humidity (%) 80 Source IMD
18 3.3 Fire Hazards and Risk Mitigation Plan
3.3.1 Fire Hazards
CIPLA has proposed solvent storage tanks for the proposed project. As per the NFPA rating the solvents such as Methanol, IPA, Hexane, Ethyl Acetate, Acetone and Toluene exhibits fire hazard and considered for consequence analysis.
Table 3-3 Solvent tank details
S.No Chemical NFPA Rating No. of Dia Height Volume Internal Pressure Type of storage Internal Tanks Temp
Fire Health Stability (m) (m) (KL) (0c) 1 Methanol 3 1 0 1 2.5 6.5 25 Under Nitrogen Underground Ambient
2 IPA 3 1 0 1 2.5 6.5 25 blanketing at 50 tank kept in Temp mili bar RCC tank and 3 Hexane 3 1 0 1 2.5 6.5 25 submerged in 4 Ethyl Acetate 3 1 0 1 2.5 6.5 25 Gravel 5 Acetone 3 1 0 1 2.5 6.5 25
6 Toluene 3 2 0 1 2.5 6.5 25 7 HSD 2 0 0 1 3 3 40 Atmospheric Above Ground
8 Furnace oil 2 2 0 1 3 4 20 Pressure
9 Methylene 1 2 0 1 2 4 15 Under Nitrogen
10 Chloroform 0 2 0 1 2 4 15 blanketing at 50 mili bar
19 The Consequence analysis study is carried out for the storage tank pipelines and the fire hazard chemicals such as Methanol, Isopropyl alcohol, Hexane, Ethyl acetate, Acetone and Toluene are stored in underground storage tank where the impacts are negligible and even risk contours maps are not generated.
Table 3-4 Chemical flowing from Storage tank pipeline details
S.No Pipe Pipeline Pipeline Operating No./Name Size dia length (m) Temperature (m) (oC)
1 Methanol 0.051 200 35
Isopropyl 2 0.051 200 35 alcohol
3 Hexane 0.051 200 35
4 Acetone 0.051 200 35
5 Toluene 0.051 200 35
20 Table 3-5: Estimated distance due to failure of Storage tank pipeline
S.No Description Event Impact Consequence Distance (m) criteria Category Category Category 1.5/F 5/D 1.5/D 1 Rupture of Methanol Vapor cloud 36500 ppm 0.09 3.27 6.06 storage tank Pipeline 73000 ppm 0.07 1.74 3.34 Jet Fire 4 kW/m2 5.69 5.52 7.02 Pool fire 4 kW/m2 11.95 12.79 11.93 12.5 kW/m2 5.98 7.36 5.99 Flash Fire 36500 ppm 0.15 3.27 6.06 73000 ppm 0.14 1.74 3.34 2 Rupture of Isopropyl Vapor cloud 10000 ppm 16.58 9.03 0.38 alcohol storage tank 20000 ppm Nil 4.81 Nil pipeline Jet Fire 4 kW/m2 5.26 7.12 5.8 12.5 kW/m2 5.04 6 5.43 37.5 kW/m2 No 5.96 No radiation radiation Pool fire 4 kW/m2 27.77 29.19 27.77 12.5 kW/m2 16.73 19.64 16.72 37.5 kW/m2 6.82 7.78 6.82 Flash Fire 10000 ppm 16.58 9.02 0.38 20000 ppm Nil 4.81 Nil 3 Rupture of Hexane Vapor cloud 5250 ppm 57.80 29.24 55.50 storage tank Pipeline 10500 ppm 39.45 16.17 32.60 76800 ppm Nil 2.53 Nil Jet Fire 4 kW/m2 10.82 13 11.72 12.5 kW/m2 8.91 10.47 9.64 37.5 kW/m2 7.92 8.94 8.51 Pool fire 4 kW/m2 25.05 27.67 25.03 12.5 kW/m2 13.33 18.21 13.34 37.5 kW/m2 4.7 5.60 4.69 Flash Fire 5250 ppm 57.72 29.23 55.50 10500 ppm 39.43 16.17 32.58 Late Explosion 0.02068 bar 106.73 41.79 75.21 worst case radii 0.1379 bar 36.86 16.19 30.65 0.2068 bar 32.64 14.60 27.95 4 Rupture of Acetone Vapor cloud 13000 ppm 42.20 18.52 34.77 storage tank Pipeline 26000 ppm 25.54 9.76 11.36 128000 ppm Nil 2.12 Nil
21 Jet Fire 4 kW/m2 11.81 13.93 12.85 12.5 kW/m2 9.96 11.68 10.84 37.5 kW/m2 Nil 10.15 Nil Pool fire 4 kW/m2 27.32 28.97 27.29 12.5 kW/m2 16.01 19.39 16.00 37.5 kW/m2 6.22 7.28 6.15 Flash Fire 5250 ppm 42.18 18.51 34.77 10500 ppm 25.53 9.76 19.86 Late Explosion 0.02068 bar 181.99 52.16 111.43 worst case radii 0.1379 bar 67.49 18.18 45.83 0.2068 bar 60.66 16.14 41.73 5 Rupture of Toluene Vapor cloud 6000 ppm 26.61 9.89 0.97 storage tank Pipeline 12000 ppm Nil 5.23 0.37 Jet Fire 4 kW/m2 4.51 6.54 5.01 12.5 kW/m2 4.16 5.37 4.49 37.5 kW/m2 Nil 4.98 Nil Pool fire 4 kW/m2 25.94 28.46 25.92 12.5 kW/m2 14.04 18.75 14.04 37.5 kW/m2 4.97 5.65 4.89 Flash Fire 6000 ppm 26.61 9.89 1.13 12000 ppm Nil 5.23 0.36
22 Scenario – 1: Rupture of Methanol Storage tank pipeline Case-1 Vapor cloud
Figure 3-1 Toxic area of vapour cloud from rupture of Methanol Storage tank Pipeline
23 Case-2 Jet fire
Figure 3-2 Jet fire from rupture of Methanol Storage tank Pipeline
24 Case-3 Pool fire
Figure 3-3 Pool fire from rupture of Methanol Storage tank Pipeline
25 Case- 4 Flash fire
Figure 3-4 Flash fire from rupture of Methanol Storage tank Pipeline
26 Scenario – 2: Rupture of Isopropyl alcohol Storage tank pipeline Case-1 Vapor cloud
Figure 3-5 Toxic area of vapour cloud from rupture of Isopropyl alcohol Storage tank Pipeline
27 Case-2 Jet fire
Figure 3-6 Jet fire from rupture of Isopropyl alcohol Storage tank Pipeline
28 Case-3 Pool fire
Figure 3-7 Pool fire from rupture of Isopropyl alcohol Storage tank Pipeline
29 Case- 4 Flash fire
Figure 3-8 Flash fire from rupture of Isopropyl alcohol Storage tank Pipeline
30 Scenario – 3: Rupture of Hexane Storage tank pipeline Case-1 Vapor cloud
Figure 3-9 Toxic area of vapour cloud from rupture of Hexane Storage tank Pipeline
31 Case-2 Jet fire
Figure 3-10 Jet fire from rupture of Hexane Storage tank Pipeline
32 Case-3 Pool fire
Figure 3-11 Pool fire from rupture of Hexane Storage tank Pipeline
33 Case- 4 Flash fire
Figure 3-12 Flash fire from rupture of Hexane Storage tank Pipeline
34 Case – 5 Late Explosion worst case radii
Figure 3-13 Late Explosion worst case radii from rupture of Hexane Storage tank Pipeline
35 Scenario – 4: Rupture of Acetone Storage tank pipeline
Case-1 Vapor cloud
Figure 3-14 Toxic area of vapour cloud from rupture of Acetone Storage tank Pipeline
36 Case-2 Jet fire
Figure 3-15 Jet fire from rupture of Acetone Storage tank Pipeline
37 Case-3 Pool fire
Figure 3-16 Pool fire from rupture of Acetone Storage tank Pipeline
38 Case- 4 Flash fire
Figure 3-17 Flash fire from rupture of Acetone Storage tank Pipeline
39 Case – 5 Late Explosion worst case radii
Figure 3-18 Late Explosion worst case radii from rupture of Acetone Storage tank Pipeline
40 Scenario – 4: Rupture of Toluene Storage tank pipeline Case-1 Vapor cloud
Figure 3-19 Toxic area of vapour cloud from rupture of Toluene Storage tank Pipeline
41 Case-2 Jet fire
Figure 3-20 Jet fire from rupture of Toluene Storage tank Pipeline
42 Case-3 Pool fire
Figure 3-21 Pool fire from rupture of Toluene Storage tank Pipeline
43 Case- 4 Flash fire
Figure 3-22 Flash fire from rupture of Toluene Storage tank Pipeline
44 3.4 SUMMARY & OBSERVATIONS
As per the NFPA rating the solvents such as Methanol, Isopropyl alcohol, Hexane, Acetone and Toluene exhibits fire hazard.
The chemical such as Methanol, Isopropyl alcohol, Hexane, Acetone and Toluene are stored in underground storage tank where the impacts are negligible and even risk contours maps are not generated.
The consequence analysis is carried out for the pipeline connected from Methanol, Isopropyl alcohol, Hexane, Acetone and Toluene solvent storage tank to process tank and found that impact is within plant premises.
It is observed for Hexane storage tank, the dispersion of vapour cloud and flash fire at minimum concentration of 5250 ppm in the wind speed of 1.5 m/s and stability class D, the impact travels to a distance of 57.50 m and found that impact is within the plant premises.
The pool fire is observed at the minimum radiation of 4 kW/m2 in the wind speed of 5 m/s and stability class D, the radiation travels to a distance of 29.19 m and found that impact is within the plant premises.
All the hazards are observed in East direction due to the wind is blowing from West direction.
3.5 Risk control measures
Instrumentation in the form of detection system, Remote Operated Valves, Level Transmitters and Pressure Transmitters to be provided. The solvent storage tanks and pipelines are based on the relevant standards and are designed considering the corrosion effects.
45 Emergency Handling checklist and procedure should be prepared and kept near the hazardous chemicals storage location. Fire protection arrangements in the form of Fire Hydrants and Monitors should be kept near all the emergency locations. Job Safety Analysis for task assessment of process activities.
BASIC PREVENTIVE AND PROTECTIVE MEASURES Adequate water supplies for fire protection. The amount/quantity of the water requirement is based on rate of firewater required for the worst possible fire and the time duration for which the fire will last. Structural design of vessels, piping, structural steel, etc. Overpressure relief devices Corrosion resistance and / or allowances Segregation of reactive materials in process lines and equipment Electrical equipment grounding Safe location of auxiliary electrical gear (transformers, breakers, etc.) Normal protection against utility loss (alternate electrical feeder, spare instrument, air compressor etc.,) Compliance with various applicable codes (ASME, ASTM, ANSI, Building Codes,Fire Codes, etc.) Fail-safe instrumentation Access to area for emergency vehicles and exits for personal evacuation. Drainage to handle probable spills safely plus fire fighting water hose nozzle sprinkler and / or chemicals. Building & equipment layout. Separation of high-hazard area must be recognized especially as it relates to born property damage & interruption of business. Provision of accessible battery limits block valves. Protection of fired equipment against accidental explosion and resultant fire. Process control rooms shall be isolated by firewalls from process control laboratories and/or electrical switchgear transformers.
46 4 MITIGATIVE MEASURES
4.1 Summary of risk analysis and findings
1. All statutory appurtenances requirement with reference to safety and fire protection have been incorporated in the design. 2. Necessary preventive and protective measures are proposed for storage tanks and handling.
4.2 Recommendations for improving safety The following measures are considered for enhancing the safety standards at site:-
1. Operator training and retraining should be a continuous effort and Mock Drills should be carried out regularly on identified scenarios.
2. Work Permit System should be strictly enforced and should not be allowed to be circumvented.
3. Hoses should be inspected and tested every six monthly for the recommended test pressure.
4. Static protection and integrity of explosion proof equipment should be ensured through regular inspection. Every electrical equipment and lighting features should meet explosion proof requirement, in classified area.
5. Smoking and carrying smoking material are to be strictly prohibited.
6. Interlock to be provided in the storage tank.
7. Earth link may be connected to pump circuit to ensure startup only after providing tank earth - connection.
8. Safety Procedures and Do’s and Don’ts should be prepared and displayed in handling and storage area.
9. Conveyor sides should have plastic guide strips in preference to metallic strips to prevent friction and consequent hazards.
10. Periodic inspection of Pipelines and painting to be done to avoid corrosion and subsequent leak.
11. The Plant commissioning has an important role to ensure long term safety. Proper cleaning and flushing of the system should be ensured in storage area and fire hydrant system to avoid possible hold up of welding slag’s, bolts, nuts etc. which could hamper smooth operation.
47 5 EMERGENCY PLAN
5.1 Objectives a. To establish a method of systematic, safe and orderly evacuation in the least possible time, to a safe area or by the nearest safe means of way out. b. Control the accidents. c. Rapid control and containment of hazardous situation. d. Rescue and treatment of casualties. e. Safeguard people (both at site and neighbourhood). f. Minimize damage to property and environment. g. Identify casualties, notify their relatives and render necessary help to them. h. Proper training of the concerned person. i. Prevent recurrence. j. Be capable of dealing with largest incident that can reasonably be foreseen. k. Have sufficient flexibility with a view to handling the emergency efficiently and avoiding unnecessary calling outside agencies like external fire brigade.
5.2 Basic forms of Emergency a. Fire b. Explosion c. Toxic release d. Natural disaster (earth quake, flooding, tsunami etc.) e. A combination of more than one
5.3 Types of Emergency 5.3.1 On-site Emergency If an accident/ incident takes place in a factory, its effects are confined to the factory premises, involving only the persons working in the factory and the property inside the factory it is called as On-site Emergency. It can be again classified as minor and major emergency based on severity of the incident.
48 Minor Emergency (Evacuation is not required) In the case of minor emergency there will be no evacuation siren and the respective department personnel will handle the same with assistance of Safety Squad. Major Emergency (Evacuation is required) In case of major emergency there will be emergency siren and situation is tackled as per the plan. 5.3.2 Off-site Emergency If the accident is such that it affects inside the factory are uncontrollable and it may spread outside the factory premises, it is called as Off-site Emergency. Assessment reveals that an Off-site emergency is a very remote possibility in our factory. If there is a situation, first we shall avail the service of local police to warn and advice the local public about things to do to save them from the effect of emergency situation. Moreover, the factory is located in industrial area. Hence, there are no residential houses in factory surrounding area.
5.4 Causes of Emergency The emergency may caused by factors like failure of system, human error, sabotage and natural calamities like earth quake, flooding etc. Irrespective of cause, the emergency will generally manifest itself in one of the three basic forms i.e. fire, explosion and release of toxic substance.
5.5 Safety, Health & Environment Policy 1. Assurance of Safety, Protection of Health & Environment is prime function and responsibility of the Management and the Management will inculcate the safety behaviour down the line through exemplary behaviour. 2. All the employees are periodically trained & informed about the hazards to which they are exposed & Safety measures to be taken including personal protective equipment. 3. To provide the resources required for Safety, Health and Environment protection. 4. We affirm to reduce the wastages, recycle the resources and disposal of wastages will be as per statutory norms.
49 5. All our facilities will be operated & maintained by the prescribed Standard Operating Procedures covering routine & non-routine activities. 6. All the accidents / near-miss accidents will be investigated thoroughly for their root cause to avoid recurrence. Corrective and preventive actions applicable for the same will be enforced. 7. Health, Safety & Environmental performance is constantly measured through periodic audits of facility for continuous improvements.
5.6 Mitigation Measures Required a. Fire Hydrant System b. Fire Extinguisher c. Emergency Equipments / PPEs d. Eye Wash Fountain and Safety Shower e. Work Zone Monitoring Equipments f. Wind Sack / Wind Direction Indicator g. Occupational Health Centre h. First Aid Boxes
5.7 Emergency Shutting Down Procedure 1. Critical operations will be shut down by the respective technician / operator upon getting the necessary instruction from the shift in charge. An emergency shut down can be done after getting approval from Incident Controller / Site Controller. 2. Utility Controls will be shut off by maintenance personnel who will know the location and operation of main controls for gas, solvent and electrical supply leading into the building. 3. An emergency shutdown of computers should be accomplished in the event of a severe electrical storm. If time permits, exit the program and shut off the computer power supply.
50 5.8 Control Room Control Room also termed as Emergency Control Centre (ECC) is a place from which all the decisions with regard to actions for control of emergency, rescue and medical treatment are made. Security office is considered as emergency control centre. It contains the following facilities. a. Communication equipment b. Copies of emergency management plan c. Emergency escape route map d. List of emergency contact numbers e. Emergency light f. Location of emergency supplies like PPEs / emergency equipments, layout of fire fighting system, assembly point etc. g. Emergency organization team details
5.9 Alert Action Plan during Working &Non Working Hours 5.9.1 Alert Action Plan during Working Hours It can be divided as follows a. Detection b. Decision c. Annunciation d. Reaction e. Recovery and Return to normal activities a) Detection
The detection of any mishap like fire, explosion or toxic release is identified by either sensors or by any person working in the plant to activate alarm system. b) Decision
The Department Head / Shift in-charge (Incident Controller) has to assess the size and nature of emergency and to decide whether it is a minor or major emergency and then to inform Site Controller immediately. c) Annunciation
51 Site Controller will get complete information of the incident, assess the incident and if require pass an order to security to wail Emergency Siren through which every Department will come to know about the emergency, then accordingly they will plan to evacuate from their respective Departments. Emergency Siren pattern, This alarm will blow in the high pitch and low pitch level with interval of 15 sec between two blows. The mechanism will be in the form of waves of high and low frequency for 3 minutes. d) Reaction
After hearing the emergency siren, all should stop their activities in a safe manner. Except Emergency Organization Team members, all should come to safe assemble area and stay there for head count and for further instruction of Site Controller. Emergency Organization Team members should act as per their pre- determined responsibility to; i. To localize the emergency and if possible to eliminate it ii. Minimize the effects of accident on people and property e) Recovery and return to normal activities
Once Emergency is mitigated, normalcy is restored; head count is matched, then Site Controller will pass an order to Security to wail All Clear Signal. All Clear Signal Siren pattern. It is a continuous alarm for one minute. After hearing the All Clear Signal, all can move to their respective work places to start their normal activities.
5.9.2 Alert Action Plan during Non-Working Hours During non working hours, i.e., in holidays, there will be no production activities. As we are carrying only batch processes, all the equipments (both process and utility) will be shut down and no chemical storage inside the production areas during holidays and also ensure the cleaning and good housekeeping.
52 All the 365 days Fire Hydrant System and Fire alarm systems are kept in active mode, to monitor this technical person and security persons will present round the clock throughout the year to tackle the worst case scenario in case of emergency.
5.10 On Site Emergency Planning A. Constitution of Teams a. Fire Fighters / Rescuers b. First Aiders c. Maintenance Team a. Fire Fighters / Rescuers . The fire fighters / rescuers shall attempt to extinguish or control the fire / prevent further toxic leakage without taking personal risk before the arrival of the fire brigade / other external agency. . The fire fighters / rescuers shall also attempt to save the lives of people who are unable to ensure their own survival without assistance. b. First Aiders . The First Aiders shall get ready the first aid equipment, proceed to designated area and set up First Aid Point in coordination with Site Controller. c. Maintenance Team The Maintenance Team shall; . The maintenance team shall go to important controlling areas like Fire Hydrant Pump House, DG area etc.
B. Define Roles And Responsibilities In Brief In the event of emergency, nominated individuals / teams are given specific responsibilities; separate from their day to day activities. The Emergency Organization Team consist, a. Site Controller (SC) b. Incident Controller (IC) c. Emergency Co-ordinator – HR & Admin
53 i. Hospital, Law & Order ii. Head Count d. Emergency Co-ordinator Maintenance e. Emergency Co-ordinator Safety Squad i. Fire Fighters / Rescuer ii. First Aider
C.1. Roles and responsibilities of Emergency Organization Team members a. Site Controller (SC) Site Controller is a person who has ultimate control over the affairs of the company during emergencies inside the plant. His responsibilities include; He should go to the Emergency Control Centre as soon as he is aware of the emergency and take over the situation. Get complete information of the incident. Assess the incident and if require pass an order to security to wail Emergency Siren. Remain in ECC and establish the contact with Incident Controller and guide him about the actions to be taken. Arrange for additional help as requested by Incident Controller with the help of Emergency Coordinators. If required call outside services like fire brigade, medical facility, water tankers, police etc with the help of Emergency Coordinators. Guide and control the traffic movements in evacuation. Establish communication and liaise with agencies like Department of Factories and Boilers, Pollution Control Board, Police and other Government Officials. Inform Incident Controller about missed people if any, after head count has been done. To issue authorized statements to the news media. Once situation is controlled, head count matched then instructs security to wail ‘All Clear Signal’.
54 Rehabilitation of affected areas after the emergency. b. Incident Controller (IC) Incident Controller is a person who is responsible for incident control measures, rescue operations and mitigation of emergency situation on Coordination with Site Controller. His responsibilities include; Proceed to the incident spot as information is received. Assess the size and nature of emergency and communicate the same to Site Controller and keep in touch with Site Controller till the emergency is mitigated / controlled. Start and direct all emergency control operations with the help of Emergency Coordinator - Safety Squads. Request Site Controller for additional help like Safety Squads from other Departments, fire brigades etc. Direct shut down of the processes / plants and also nearby plants. Ensure evacuation of all personnel in coordination with Site Controller. Once emergency is mitigated, normalcy is observed, instruct Site Controller for the same. c. Emergency Co-ordinator – HR & Admin HR & Admin team consist two persons, one person will be stationed at the Emergency Control Centre during the emergency to handle hospital, fire, police and other inquiries under instruction of Site Controller and other person will carry out headcount at assembly point and pass on the absentee information to the Site Controller. i. Emergency Co-ordinator Hospital, Law & Order His responsibilities shall include - Proceed to the Emergency Control Centre and report to Site Controller. Ensure the gates are closed. With the help of security, control crowd at gate as per instruction from Site Controller.
55 Deploy one guard at main gate with instructions not to allow / send any personnel, vehicles inside except fire tender and ambulance. Keep ready the list of important telephone numbers and contact numbers of police and other law and other agencies. Inform other statutory departments, corporate office as per instruction from Site Controller. Inform relatives / contact persons of the injured accordingly. Get hold of medical management procedure / list, hospital / telephone numbers, accordingly. Call the respective medical institute as per the instruction from Site Controller. Prepare a sequential report of the incident. ii. Emergency Co-ordinator Head Count His responsibilities shall include - Proceed to the Emergency Control Centre and report to Site Controller Ensure carrying Master Attendance Copy. Proceed to assembly point and collect attendance sheet from respective department. Compare the list and look for missing personnel if any. Inform Site Controller about the same. d. Emergency Co-ordinator Maintenance Emergency Co-ordinator Maintenance will take care of emergency control systems like Fire Hydrant System, DG units etc and also mobilize the tool and other emergency equipments as per the instruction of Site Controller. One of the co-ordinator will move to Fire Hydrant pump house and switch on /off the pump as per the instruction of Site Controller. One of the co-ordinator will move to Generator room and switch on / off as per the instruction of Site Controller. One of the co-ordinator will be available on phone and act as per the instruction of Site Controller.
56 e. Emergency Co-ordinator Safety Squad Emergency Co-ordinator Safety Squads will fight the emergency to mitigate it and to protect life, property. i. Emergency Co-ordinator Fire Fighters / Rescuer Proceed to the incident spot along with emergency equipments and report to Incident Controller. Set up emergency equipment. Act as per the instruction of Incident Controller. Make quick assessment of the injured and arrange to shift with the help of Incident Controller to safer place for first aid. Send one co-ordinator of the team along with injured. Search for missed ones and do rescue operation for the needy.
ii. Emergency Co-ordinator First aider Proceed to Emergency Control Centre along with team and report to Site Controller. Set up emergency equipments. Be ready to receive and to provide first aid to victim and to help the ambulance staff. Make quick assessment of the injured and arrange to send victim to hospital with the coordination of Site Controller. Send one co-ordinator of the team to hospital along with injured with medical management procedures.
C.2. Roles and responsibilities of persons other than Emergency Organization Team members Do not venture out for help. Be available in the Department till evacuation is called. After hearing the Emergency siren, all should stop their work in a safe manner immediately. All work permits will be cancelled automatically.
57 All should come to Safe Assembly Area (In front of Safety Office). While coming to Safe Assemble Area, . Do not run, walk brisk. . Do not use lift, use only staircase. . Do not block staircase, use hand rail. Come in a line. . Do not obstruct / block the path to Emergency Organization Team members. Do not go back for your belongings. Do not use telephone except for emergency purpose. Follow instructions of Site Controller in Safe Assemble Area. After All Clear Signal, all can go back to their respective places / Departments. C. Notification of Emergency The notification of any mishap like fire, explosion or toxic release is identified by either sensors or by any person working in the plant. If detection by sensors, alarm system will get activated or if it by a person, he will activate alarm system. As soon as Incident Controller aware of the emergency, he will rush to incident spot and assess the size and nature of emergency and communicate the same to Site Controller. D. Declaration of Emergency Site Controller will be the person to decide whether the situation warrants evacuation of the premises or is a localized incident. This individual will be termed as the declarer of emergency. Immediately the declarer will make arrangements to give information to the Executive Director. Once an emergency requiring evacuation has been decided upon by the declarer, the Emergency will be declared by putting on the Emergency Siren. E. Evacuation of Personnel All Safety Squad co-ordinators from the Department where the incident has occurred and from other Department will reach earliest to the point of incident. All other people working in the factory will assemble at designated assembly point i.e., in front of Safety Department after hearing the Emergency Siren. The Emergency co-ordinators will assist in directing the individuals to the assembly point.
58 F. Accounting of Personnel The Emergency Co-ordinator HR & Admin, Head Count Person will conduct head count as per particular days attendance record at the assembly point to account for persons working inside the factory and also for visitors / vendors present inside the premises. Information on missing persons will immediately convey to Site Controller. G. Controlling of Emergency The Safety Squad member from the affected area and Safety Squad members from other Departments will attempt to control / mitigate the emergency situation under the supervision of Incident Controller and instruction of Site Controller. H. Arrangements for Medical Treatment Any person injured in the incident and subsequently, will be treated by Emergency coordinator, First Aider. First Aid team member will accompany the injured to hospital. In the event of additional medical help, the injured will be shift to recommended Hospital. I. Information to the Relatives of the Injured The relatives of injured will be informed by Emergency Coordinator HR & Admin for Hospital, Law & Order. The communications to the relatives of injured will be through telecom or by a messenger. The clear address of availability of the injured person (if hospitalized) will be communicated to his relatives. J. Information to the Government Authorities The Emergency Coordinator HR & Admin for Hospital, Law and Order is the person to inform and get help from Fire Station, Police and other Government Hospitals in coordinating with Site Controller. K. Law & Order Site Controller will take over and control emergency in coordination with Incident Controller and other Emergency Coordinators. The Executive Director will arrange to send information regarding the incident to the Director of Factories, Government of Karnataka. L. All Clear Signal Once Emergency is mitigated, normalcy is restored; head count is matched, then Site Controller will pass an order to Security to wail All Clear Signal.
59 After hearing the All Clear Signal, all can move to their respective work places to start their normal activities. 5.11 Offsite Emergency Plan 5.11.1 Preamble An offsite emergency arising out of chemical hazards in one, which has potential to cause serious damage or loss of life beyond the plant boundary. In addition, Accidents during transportation of hazardous chemicals by road, rail, pipeline etc. can cause offsite emergencies. Emergency services such as Police, Fire, Medical etc., need to be prepared to handle such situations promptly and effectively. It is mandatory under Rule 16 of the Hazardous Chemical Rules for District authorities to prepare an off-site emergency plan in respect of clusters of hazardous chemical industries or at locations where accidents are likely to have an off-site adverse effect. In order to be in a state of preparedness to respond to the accidents and minimize their adverse impacts on the offsite population, requires an offsite emergency plan to be prepared by the District Controller for every District or Industrial Areas as applicable. 5.11.2 Objective The objective of the present assignment is to prepare an area specific Offsite Emergency Action Plan for Karnataka which can be practically implemented / activated at a short notice to ensure minimal impact on life and property due to emergencies arising out of Chemical Accidents or during Transportation of Hazardous Chemicals in the district. The plan should be regularly updated when there are changes occurring in the Industrial set up, Transportation Aspects, Key Manpower and Administrative Changes etc., Regular drills, Training of key persons, increasing safety awareness etc is extremely important areas that must be looked into for sound preparedness. 5.11.3 Offsite Emergency Control As we all know that KIADB industrial area having many industries of large, medium & small scale. After the “Bhopal Gas Tragedy” (Methyl Isocyanides- MIC Poisonous and toxic gas release Accident at Union Carbide, 1984) the Government felt an immediate need to be more conscious about handling of Hazardous Chemicals.
60 Central control room Centre or Offsite Industrial Emergency Control Room “OIECR” should be established by company. It should work under the Governing Council. The Governing Council should be headed under the chairmanship by District Collector & Magistrate. The Governing Council Members are the permanent Ex. Officio Members to manage the affairs of the Emergency Control Room. 5.11.4 Emergency Instruction to the General Public The Notification of Emergency The emergency can be declared by following media to alert or alarm the public; 1. Public address system 2. Blow horns/Bells 3. Sirens / Hooters 4. Telephone message / Fax Messages / Hot lines/ Pager / E-mail / Mobile Phone / Satellite system 5. Sending messages through a messenger 6. Rushing personally to the Central Control Room or to the nearest Police Department or Fire Department for declaration of emergency. 7. Raising of Flag for denoting the level of natural calamities 8. Ham Radio 9. By any other source by which information can reach to the public in time. 5.11.5 Category of Alarm Systems The following alarm system may be considered which will identify the various level of emergency. 5.11.5.1 First Level Warning (Fire Alarm) For an accident / incident within the unit Hooter / Siren – Short, intermittent 5.11.5.2 Second Level Warning When the District Authority receives information that a toxic or flammable gas has leaked then the siren has to be sounded in order to facilitate early evacuations from the unit. Siren – A wailing short and long intermittent siren notification of emergency. 5.11.5.3 Third Level Warning (All Clear)
61 When the District Authority considers that the accident / incident is under control, emergency is withdrawing and it is safe for re-entry. Siren – A wailing, long and continues, intermittent siren. 5.11.6 Fire Fighting System In order to tackle great risk of fire explosion, spillage of hazardous liquid or release of toxic gases, fire fighting system should be mobilized under chief fire officer. The operational response will be coordinated from the Central Control Room. 5.11.7 General Instruction to the Public A major emergency may affect areas outside the works. The surrounding public will be alerted with public address system by Police or Government Authorities or nearby industrial concerns. The siren / hooter will blow to indicate arising the emergency situation. It will be indicated which kind of emergency arised, Start the Radio / TV for further instruction & act accordingly. So that public will take prompt action to protect them-selves or rush to the safe shelter as instructed by the authority. First of all to ascertain which type of emergency arised. 1. Fire 2. Explosion 3. Gas Leakage / Release 4. Collapse of Building, Brusting of Vessel etc. 5. Natural Calamities. If gas leakage emergency arised, ascertain probability of gas whether flammable, toxic or poisonous. The following actions are suggested as per prevailing situation: Otherwise follow the instruction as issued by the authority 5.11.7.1 Flammable Gas : a. Be calm, don’t get panicky b. Do not light Cigarette etc c. Shut down open flame, gas and electrical instruments or any source of ignition d. Do not move any vehicle in the area e. Do not go near the incident & don’t allow any others f. Shut down the windows, doors etc. & seat open ground or terrace. g. Follow the instruction as directed by the authority
62 5.11.7.2 Toxic Poisonous Gas a. Cover your nose with wet hand kerchief / cloth and breath through it. b. Come out in open, check the wind direction and move away quickly in perpendicular direction of wind. (cross wind direction ) c. Immediately go & try to get to a higher elevation, if gas is heavier than air (like chlorine, as it settles in low lying area) Follow the instruction and reach safe shelter as instructed notified by Government Authority or Public authority. 5.11.7.3 General Instruction : (A) DON’T 1. Do not get panicky, be calm 2. Do not approach the site of incident as a spectator 3. Do not approach unnecessarily for information or more enquires 4. Do not allow unnecessarily crowd nearby incident place 5. Do not believe in rumors unnecessarily (B) DO’S 1. Listen radio, TV or Public Addressing System. 2. Emergency will be communicated by public addressing system / TV / Radio or siren (Siren- code wailing sound for one minute) 3. Follow the instruction & convey to others accordingly 4. On announcement of withdrawal of emergency or clearance Siren, start your routine work 5. On enquiry, deposit your statement as required by authority at the time of investigating the incident 6. Co-operate, help and assist the person(s) / authority handling the emergency and rescue operation.
5.11.8 Security & Police Security, protection of life & property and traffic control & maintenance of law and order should be taken care by police. During an emergency duties and responsibilities of the police may be: a) Cordoning of the incident area b) Warning public about the hazards
63 c) Traffic Control d) Assist fire fighting services e) Assist first-aid medical teams f) Assist evacuation and ensure protection of property in evacuated areas. Different phases of emergency management practices would be as under: a) Before the Crisis Proper planning of manpower, transport and communication network to coordinate possible incident areas and regulation of traffic should be made for each industry in the area. b) During the Crisis The Security Commander of the area will set in motion the relevant contingency plan to control the operation. c) After the Crisis Protect property in the evacuated area. d) Media The Control Room should release up-to-date information to the media to the people.
64 Bommasandra RDPATM120112142256529
ON SITE EMERGENCY PLAN
CIPLA Ltd. Plot No. : 285,286 &287 KIADB IV th Phase Jigani-Bommasandra Link Road, Bommasandra, Bangalore-105
1 Bommasandra
Table of contents Sl. No Details of section Page no:
1 INTRODUCTION 4
2 PROFILE OF THE COMPANY 5,6
3 SAFETY, HEALTH & ENVIRONMENT POLICY 7
4 BRIEF MANUFACTURING ACTIVITY (WITH FLOW CHARTS) 8-13
WORKING PATTERN AND DECLEARED GENERAL 14 5 HOLIDAYS
6 GEOGRAPHICAL LOCATION(COLOR MAP) 15
7 DEMOGRAPHY DETAILS 16-17
METEOROLOGICAL DATA WITH WIND DETAILS AND 18 8 DIRECTIONS
9 WIND DETAILS AND DIRECTION 19
10 CHEMICAL DATA 20-21
IDENTIFICATION OF HAZARDS IN EACH DEPARTMENTS/SECTION WITH HAZARD AREA MAP AND 11 AFFECTING POPULATION
IDENTIFICATION OF EMERGENCY IN EACH HAZARD 12 ACTIVITY THROUGH RISK ANALYSIS
SEVERITY /SEVERITY MAPPING(ZONING DIAGRAM)- 13 ANNEXURE
14 MITIGATION MEASURES REQUIRED
MITIGATION MEASURES POSSESSED/PROPOSED BY THE 15 INDUSTRY
16 EMERGENCY SHUTTING DOWN PROCEDURE
17 IDENTIFICATION OF MUTUAL AID PARTENERS
2 Bommasandra Sl. No Details of section Page no:
IDENTIFICATIONS OF RESOURCE SUPPLIERS( BOTH 18 PUBLIC AND PRIVATE)
19 EMERGENCY TRANSPORT FACILITY
20 CONTROL ROOM
ALERT ACTION PLAN DURING WORKING/NON WORKING HOURS 21
22 EMERGENMCY ORGANIZATION CHART
23 ON SITE EMERGENCY PLANNING
24 ESTABLISH LINE OF CONTROL-RESPONSIBILITY & ALTERNATIVE LINE OF CONTROL
24.1 CONSTITUTION OF TEAMS
24.2 ROLE AND RESPONSIBILITY IN BRIEF
24.3 NOTIFICATION OF EMERGENCY 24.4 DECLARATION OF EMERGENCY 24.5 EVACUATION OF PERSONNEL
24.6 ACCOUNTING OF PERSONNEL 24.7 CONTROLLING OF EMERGENCY 24.8 ARRANGEMENTS FOR MEDICAL TREATMENT 24.9 INFORMATION TO THE RELATIVES OF THE INJURED
INFORMATION TO THE GOVERNMENT AUTHORITIES 24.10 LAW AND ORDER 24.11 ALL CLEAR SIGNAL 24.12
24.13
3 Bommasandra
1. INTRODUCTION:
Emergency planning is an integral and essential part of loss prevention strategy. The type of emergency primarily considered here is the major emergency which may be defined as one which has the potential to cause serious danger to persons and or damage to property and which tends to cause disruption inside and or outside the site and may require the use of outside resources. Emergency is a general term implying hazardous both inside and outside the installations. Thus, emergencies are termed “On-Site” when it confines itself within the plant even though it may require external help and “Off-Site” when emergency extends beyond its premises. It is to be understood here, that if an emergency occurs inside the plant and could not be controlled, it may lead to an off-site emergency.
1.1 Name and Address of the Site:
CIPLA Ltd. Plot No. : 285,286 &287 KIADB IV th Phase Jigani-Bommasandra Link Road, Bommasandra, Bangalore-105
1.2 Contact Persons
At Corporate Office: Mr. Kuber Jagdale Email ID: [email protected]
At site : Mr. Krishna Rao Email ID : [email protected]
1.3 Address of the Corporate Office Address of the Site
Cipla Ltd. Cipla Limited Mumbai Central Plot No 285,286&287 Mumbai 400 008 Bommasandra Jigani Link Road India KIADB Indl Area, 4th Phase Bangalore-560105
: +91-80- 2308 2891 : +91-80- 2205 9217 : +91-80- 2307 0013 : +91-80- 2205 9220
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2. PROFILE OF THE COMPANY
M/s. Cipla Limited is a professionally managed Public Limited Company established in 1935. It manufactures and markets a wide range of Pharmaceutical Formulations and Bulk Drugs.
The Corporate headquarters are located in Mumbai Central, where senior qualified corporate personnel are available for providing support to the manufacturing plants in the areas of Technology, Research and Development, Manufacturing, Quality Control, Quality Assurance and Safety, Health &
Environment
The Company has manufacturing facilities at the following locations.
. Bangalore, . Patalganga . Kurkumbh . Goa . Indore . Baddi . Sikkim We have a strong team of specialists in Safety, Environment Management. The management takes all practicable steps to ensure safe & healthy environment by providing intrinsically safe plants, clearly defined procedures & norms complying with statutory requirements. The facility is equipped with full fledged Fire Hydrant Systems, Addressable Smoke /Fire/Heat detection system, Hydrogen detectors, dedicated breathing apparatus, safety shower, eye washer, personnel protective equipment, fire extinguishers , Multigas detectors etc. . Personnel are continuously trained in all aspects of safety.
5 Bommasandra
Advanced technologies planned to implement • Usage of Agitated Nutsche filter Dryer in place of conventional centrifuges • Usage of isolators to ensure no solid exposure to humans as well as Environment • More efficient (40%) spiral condensers in place of shell and tube • Chilled water usage to condensers instead of Cooling tower water • Closed loop solvent handling with PLC operating system • Single fluid heating and cooling system (-80oC to 140oC) • Process controlled (Production) through DCS • Advanced instrumentations to control levels and Temperature. • Zero liquid discharge concept for Effluent Treatment • Rain water harvesting
6 Bommasandra 3. SAFETY, HEALTH & ENVIRONMENT POLICY
7 Bommasandra
4. BRIEF MANUFACTURING ACTIVITY WITH FLOW CHARTS
This is a chemical process which involves the conversion of starting raw material to finished Active Pharmaceutical Ingredients. The process involves the following steps.
(i) Reaction (ii) Distillation (iii) Work up (iv) Drying (v) Milling& sifting (vi) Packing
(i) Reaction:
The raw material reacts with reactant in solvent medium at controlled temperature.
(ii) Distillation:
Distillation is a method of separating mixtures based on differences in their volatilities in a boiling liquid mixture.
(iii) Work up:
This involves the following reactions. Quenching a reaction to deactivate any un reacted reagents. Cooling the reaction mixture or adding an anti solvent to induce precipitation, and collecting or removing the solids by filtration, decantation, or centrifugation. Removal of solvents by evaporation. Separating the reaction mixture into organic and aqueous layers by liquid-liquid extraction. Purification by chromatography, distillation or re crystallization.
(iv) Drying:
Drying is a mass transfer process consisting of the removal of water moisture or moisture from another solvent, by evaporation from a solid, semi-solid or liquid.
(v) Milling & sifting:
This process involves the size reduction of particles from bigger size to smaller size.
(vi) Packing:
The milled product is packed in standardized in the form depending upon the customer requirement.
8 Bommasandra PROCESS FLOW CHART
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5. WORKINGPATTERN AND DECLEARED GENERAL HOLIDAYS
WORKIUNG HOURS
SHIFTS HOURS NO OF WORKERS NO OF VISITORS PRESENT 1ST SHIFT 7.00 am to 3.00 pm NIL
2ND SHIFT 3.00 pm to 11.00 pm NIL
NIGHT SHIFT 11.00 pm to 7.00 am NIL
GENERAL 8.30 am to 5.00 pm 10
WEEKLY HOLIDAY - SUNDAY DECLEARED GENERAL HOLIDAYS (Declared holidays are as per the Karnataka Industrial Establishments National and Festival Holidays Act, 1963 and Rules there under.)
Sl. No. Festival/Occasion DAY/DATE
1 Makara Sankranthi JAN 14
2 Republic day JAN 26
3 Chandramana Ugadi APR 04
4 Independence Day AUG 15
5 Ganesh Chaturthi SEP 01
6 Ayudha Pooja OCT 05
7 VijayaDashami OCT 05
8 Diwali OCT 05
9 Diwali OCT 05
10 Kannada Rajyostava day Nov 01
10 Bommasandra 6. GEOGRAPHICAL LOCATIONS
Bangalore district is situated in the heart of the South- Deccan plateau in peninsular India to the South – Eastern corner of Karnataka State between the latitudinal parallels of 12° 39’ N & 13° 18’ N and longitudinal meridians of 77° 22’ E & 77°52’E at an average elevation of about 900 meters covering an area of about 2,191 sq.kms (Bangalore rural and urban districts).
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7. DEMOGRAPHY DETAILS:
With an estimated population of 5,281,927 in the year 2007, Bangalore is the third most populous city in India and the 27th most populous city I the world. With a decadal growth rate of 38 %, Bangalore was the fastest- growing Indian metropolis after New Delhi for the decade 1991-2001. Scheduled Castes and tribes account
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13 Bommasandra 8. METEOROLOGICAL DETAILS: Climate: Bangalore is considered to be climatically a well- favored district. The climate of the district is classed as the seasonally dry tropical savanna climate with four seasons. The dry season with clear bright weather is from December to February with summer from March to May followed by the southwest monsoon season from June to September. October and November constitute the post-monsoon or retreating monsoon season. The main features of the climate of Bangalore are agreeable range of temperatures, from the highest of 33 0 C in April to the lowest minimum of 14 0 C in January. The two rainy seasons, June to September and October to November, come one after other November WEATHER STATISTICS OF BANGALORE CITY (For the year 2008)
1. Annual rainfall 1286.6 mm
2. Hottest Month April(36.90C)
3. Mean Maximum Temperature of Hottest Month 33.00C
4. Coldest Month January(13.60C)
5. Mean Minimum Temperature of Coldest Month 16.10C
6. Wettest Month August(309.8 mm)
7. Normal Rainfall of Wettest Month 137.0 mm
8. Driest Month January(0.1 mm)
9. Normal Rainfall of Driest Month 2.7 mm 10. Extreme Values:
38.90C; a. Highest Maximum Temperature ever recorded Date: 22.05.1931
7.80C; b. Lowest Minimum Temperature ever recorded Date:13.01.1884
178.9mm; c. Heaviest 24 hrs rainfall Date: 1.10.1997
1431.8mm; d. Highest annual rainfall Date: 1998
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9. WIND DETAILS & DIRECTION:
The Surface winds in Bangalore have seasonal character with Easterly components predominating during one period followed by tht Westerly in the other. The high wind speed averages 17kmph during the westerly winds in the month of July and a minimum of 8-9 kmph during the months of April and October.
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16 Bommasandra 10. CHEMICAL DATA
NAMES OF TECHNICAL CA UN NUMBER DESCRIPTION STORAGE MONTHLY METHOD OF CHEMICALS NAME S OF THE QUANTITY COPNSUM STORAGE NO HAZARD PTION (TPM) Acetone ACETONE - 1090 F & E 25 KL 10 Under Ground tank
Ethyl Acetate F & E 25 KL 15 Under Ground tank
Toluene F & E 25 KL 4 Under Ground tank
Methanol METHYL 67- 1230 F & E 25 KL 15 Under Ground tank ALCOHOL 56- 1 Isopropyl Alcohol F & E 25 KL 10 Under Ground tank
HSD Fire 20 KL
Furnace Oil Fire 40 KL
Acetonitrile ACETONITR - - F & E 50 Nos of 8 ILE Drums Pyridine F & E 50 Nos of 2 Drums Di isopropyl ether F & E 25 Nos of 1 Drums Tetrahydrofuran F & E 15 Nos of 1 Drums n-Hexane F & E 15 Nos of 1 Drums
17 NAMES OF TECHNICAL NAME CAS NO UN DESCRIPTION OF STORAGE MONTHLY METHOD OF STORAGE CHEMICALS NUMBER THE HAZARD QUANTITY COPNSUMPTION Bommasandra Kg/Month MEROPENEM NS 500 500 DRUM SODIUM SODIUM --- -- 150 150 BAGS CARBONATE CARBONATE N- METHYL N- METHYL 2500 2500 DRUM PYROLIDONONE PYROLIDONONE THIENA CYCLIC 500 500 DRUM METHYLENE DI METHYLENE DI 4500 4500 DRUM CHLORIDE CHLORIDE CYSTAMINE HCL CYSTAMINE HCL 330 330 DRUM DIPHENYL DIPHENYL 3265 520 520 DRUM CHLORO CHLORO PHOSPHATE PHOSPHATE ACETONITRILE ACETONITRILE 1500 1500 DRUM BENZYLE BENZYLE 225 225 DRUM FORMAMIDATE FORMAMIDATE AB ALCOHOL AB ALCOHOL 1170 FIRE 500 500 DRUM SODIUM SODIUM --- 150 150 BAGS CHLORIDE CHLORIDE SODIUM SODIUM FIRE 90 90 DRUM METHOXIDE METHOXIDE CILA ACID CILA ACID 70 70 DRUM HYFLO HYFLO ------50 50 BAGS SODIUM BI SODIUM BI --- 11 11 BAGS CARBONATE CARBONATE CARBONDI CARBONDI 50 50 CYLINDER OXIDE OXIDE ERTAPENEM 240 240 DRUM SIDECHAIN CYCLIC BASE 150 150 DRUM PHOSPHORIC PHOSPHORIC ACID 1805 120 120 CARBOYS ACID n-PROPANOL n-PROPANOL 12000 12000 U G STORAGE TANK CILASTAIN ACID CILASTAIN ACID 500 500 DRUM SOD.-2 ETHYL SOD.-2 ETHYL 250 250 DRUM HEXONATE HEXONATE PANIPENEM SIDE 250 250 DRUM CHAIN DORIPENEM SIDE 200 200 DRUM CHAIN SILLYL 150 150 DRUM FAROPENEM SIDE CHAIN PNB SILLYL 150 150 DRUM SULOPENEM ALLYL
18 Bommasandra 11. IDENTIFICATION OF HAZARDS IN EACH DEPARTMENTS/SECTION WITH HAZARD AREA MAP AND AFFECTING POPULATION
SL DEPARTMENT NATURE OF HAZARD EFFECTED NO WORK POPULATION 1 PRODUCTION HANDLING TOXIC RELEASE 24 CHEMICAL FIRE AND EXPLOSION REACTIONS 2 MAINTENANCE REGULAR WORK FIRE 12 ELECRTRICAL ELECTRICAL HAZARDS WORK FABRICATION WORK 3 QUALITY CHEMICAL FIRE AND EXPLOSION 10 CONTROL ANALYSIS CHEMICAL EXPOSURE CHEMICAL MIXING 4 R&D CHEMICAL FIRE AND EXPLOSION 5 REACTIONS CHEMICALEXPOSURE CHEMICAL MIXING GAS HANDLING 5 STORES MATERIAL FIRE 5 HANDLING CHEMICAL EXPOSURE SOLVENT LOADING AND UNLOADING CHEMICAL HANDLING
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12. IDENTIFICATION OF EMERGENCY IN EACH HAZARD ACTIVITY THROUGH RISK ANALYSIS
20 Bommasandra RISK ASSESSMENT
Name of Person Undertaking Assessment Date Department / Area (including description of what is being assessed) Conducted A.M.KULKARNI 10/03/09 ABOVE GROUND STORAGE TANKS HOUSING FLAMMABLE SOLENTS
Ref Hazard under review No & Existing Controls Assessed Level of Further Action Required By (Date) No Descriptio Risk* + Review n of staff Date involved L M H 1 X SOP for various operations inside the tank area Fire and Explosion Staff to highlight fire safety issues and corrective -Air and vapour mixture formation while Workmen actions. loading, unloading sampling and Casuals Identification of flammables for air vapours dispensing of solvents. mixture inside the tank. -Formation of air+vapour mixture inside Vapour space to be filled with inert gas. the storage tank. Installation of flame arrester in combination -Poor control of external ignition sources with breather arrangement. inside the tank area. Ensuring complete discharge of electrostatic -In adequate separation distances from accumulation from the tanker using earthrite. the tank area and adjacent buildings. Tanker unloading permit procedure. -Electrical installations not as per Fire protection by sprinkler system around the haz.area classification. storage tank and tanker. -Failure of FLP fixtures. Distances maintained as per statutory -Non provision of FLP fixtures. regulations -Formation and discharge of static Selection of electrical installations as per IS-2148 charges. or any other international body. -Usage of sparking tools. Effective PMP for FLP fixtures. -External ignition sources. LEL detectors. -Absence of hot work permits system. Ensuring of earthing and bonding through recording in BMR Electrostatic bonding Avoid and prevent personnel acquiring electro static charges Non sparking tools Effective works permit system. Vents fixed with flame arresters. Release of vacuum through nitrogen. Display of prohibition of spark producing materials in to tank farm.
21 Bommasandra 2. Pressure Staff X Solvents with high evaporation rate should have -extreme heat Workmen cooling arrangement. -sudden cooling Casuals Sprinkler system with heat detector. -choking of flame arrester and breather and Adequate maintenance of pressure relieving valve. visitors systems -sudden increase in inertising pressure. PMP for breather and flame arresters. -impingement of heat due to external fire. Design of tank adequate to sustain pressure and -Non functioning of sprinkler or other vacuum. cooling arrangement. Inertising pressure regulated. -Decomposition of the product. Residues with potential for decomposition to be avoided. 3. Exposure hazards. Staff X Respirators approved by NIOSH. EN or Dermatitis with prolonged contact with Workmen equivalent IS. solvents. Casuals Full face protection. Severe chemical burns due to splashing of Emergency shower and eye wash solvents. Spill control materials like sorbent pads and booms. Spill control training. Hazard communication training
22 Bommasandra Name of Person Undertaking Assessment Date Department / Area (including description of what is being assessed) Conducted A.M.KULKARNI 10/03/09 DRUM STORAGE SHED
Ref Hazard under review No & Existing Controls Assessed Level of Risk* Further Action Required By (Date) No Description + Review of staff Date involved L M H
1 X LEL detectors instead of smoke detectors. Fire and Explosion Staff Electrostatic bonding -Air and vapour mixture formation while Workmen Avoid and prevent personnel acquiring electro sampling and dispensing of flammable Casuals static charges materials. Non sparking tools. -Usage of air for dispensing solvent from Provision of gas, vapour leak detection systems the drum. Usage of extremely low pressure Nitrogen for - dropping and rolling of solvent drums. dispensing. -Chemical compatibility not observed. Effective works permit system. -Failure of FLP fixtures. -Non provision of FLP fixtures. -Formation and discharge of static charges. -Usage of sparking tools. -External ignition sources. -Absence of hot work permits system. -Non provision of gas/vapour leak detection.
2. Pressure Staff X -Air moisture sensitive materials stored in -Decomposition of the product. Workmen controlled conditions. -use of uncontrolled pressure of Casuals -mechanical arrangements to place the drums. air/nitrogen for dispensing. and visitors -Heat from external sources prevented. -exposure to external source of heat. -Integrity of the container maintained after -admittance of air or moisture in to the sampling. drums containing sensitive materials. -Use of low pressure nitrogen. - -The storage place checked periodically and containers for pressure regularly.
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3. Exposure hazards. Staff X Respirators approved by NIOSH. EN or Dermatitis with prolonged contact with Workmen equivalent IS. solvents. Casuals Extra long acid alkali gloves while handling Severe chemical burns due to contact of corrosive solids and liquids. corrosive chemicals. Spill control materials like sorbent pads and Severe respiratory problems due inhalation booms. of corrosive fumes. Chemical emergencies handled with SCBA While dealing with spills and similar Water reactive materials stored separately. emergency conditions. Spill control training. Life threatening situations while dealing Hazard communication training with chemicals releasing toxic gases like H2S.
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13. SEVERITY /SEVERITY MAPPING (ZONING DIAGRAM)- ANNEXURE
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14.& 15. MITIGATION MEASURES REQUIRED,MITIGATION MEASURES POSSESSED/PROPOSED BY THE INDUSTRY
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SL. NO. LOCATION NAMES OF CAS NO STORAGE HAZARDS MITIGATION MEASURES MEASURES REQUIRED CHEMICALS QUANTITY AVAILABLE STORED (litres/kgs)
1 2 3 4 5 6 7 1 WARE IPA 67-63-0 800 FLAMMABLE FIRE EXTINGUISHERS, HC DETECTORS HOUSE SMOKE DETECTORS, SEC. CONTAINMENT SPILL CONTROL KIT 2 WARE HCl 7647-01-0 400 CORROSIVE SPILL CONTROL KIT EMERGENCY HOUSE SHOWER 3 WARE SOD.HYDROXI 1310-73-2 500 CORROSIVE SPILL CONTROL KIT EMERGENCY HOUSE DE SHOWER 4 SOL.YARD HSD 68476-30-2 15KL FLAMMABLE FIRE EXTINGUISHERS, FOAM COMPOUND SMOKE DETECTORS, SPILL CONTROL KIT
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16. EMERGENCY SHUTTING DOWN PROCEDURE
HAZARDS POSSIBLE HAZARDS SHUTTING DOWN PROCEDURE GENERAL FIRE FIRE AND SWITCH OFF POWER SUPPLY TO AFFECTED AREA EXPLOSION USE MCP TO COMMUNICATE EMERGENCY TEAM REMOVE OTHER INFLAMMABLE AND COMBUSTIBLE MATERIALS SOLVENT RAISE OF HIGH STOP THE AGITATOR DISTILLATION TEMPERATURES STOP THE HEATING AND PRESSURE, APPLY COOLING TO THE JACKET OF AND EXPLOSION AND INFORM TO THE HIGHER AUTHORITY FOR FIRE HAZARD FURTHER ACTION AND SHUT DOWN THE PLANT ELECTRICAL FIRE ELECTRIC FIRE AND SWITCH – OFF THE ELECTRICAL SUPPLY OF THE SHOCK EQUIPMENT OR PANEL INVOLVED IN THE FIRE SWITCH – OFF THE MAINS OF THE ENTIRE SECTION IN CASE FIRE SPREAD REMOVE FLAMMABLE LIQUID DRUMS MATERIALSWHICH ARE LIKELY TO CATCH THE FIRE USE ONLY DCP OR CO2 FOR EXTINGUISHING THE FIRE
DG FIRE USE NEARBY FOAM EXTINGUISHER IF FIR IS SMALL USE MCP AND COMMUNICATE TO EMERGENCY TEAM CLEAR THE AREA OF DIESEL AND OTHER COMBUSTIBLE MATERIALS CHANGE DG CONTROL PANEL SWITCH TO OFF MODE AND SWITCH OFF DG BY TURNING THE KEY TO OFF POSITION ISOLATE FUEL SUPPLY BY CLOSING THE VALVE HAZARDS POSSIBLE HAZARDS SHUTTING DOWN PROCEDURE FIREBOILER (DIESEL EXPLOSION LEAVE THE PLACE IF RISE IN TEMP AND FIRED) PRESSURE IS RAPID. COMMUNICATE TO ALL BY USING MCP SWITCH OFF BOILER FIRING AND FD FAN KEEP WATER RUNNING IF AUTOMATION FAILS THEN PERFORM THE ABOVE OPERATION ARRANGE FOR BLOWDOWN DO NOT LEAVE THE PLACE UNTILL NORMALCY IS ACHIEVED,
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17. IDENTIFICATION OF MUTUAL AID PARTENERS
SL PARTNER CONTACT AID EXPECTED NO NUMBER 1 Biocon Limited 080-28082000 FIRE SAFETY AND FIRST AID 2 Sigma Aldrich Chemicals Pvt 080-66219410 FIRE SAFETY AND Limited FIRST AID 3 Apotex pharmachem India Pvt 080-22891000 FIRE SAFETY AND Limited FIRST AID 4 Apotex Research Pvt Limited 080-22891014 FIRE SAFETY AND FIRST AID 5 Hikal Limited 080-39861100 FIRE SAFETY AND FIRST AID 6 Microlabs Limited 080-41564748 FIRE SAFETY AND FIRST AID 7 Syngene International Limited 080-28082000 FIRE SAFETY AND FIRST AID 8 Biocon Biopharmaceuticals 080-28082000 FIRE SAFETY AND Private Limited FIRST AID
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18.IDENTIFICATION OF RESOURCE SUPPLIERS (BOTH PUBLIC AND PRIVATE)
NAME OF THE COMAPNY ADDRESS USHA ARMOUR PVT LTD SUNDARI,#102, 4TH A MAIN, 6TH CROSS, NS PALYA,BILEKAHALLI, BANNERGHATTA ROAD, BANGALORE – 78 PHONE- 080-4022055 FAX- 080- 40220575 CONTACT PERSON- MR. SHIVAKUMAR CABSON ENTERPRISES #34, SP ROAD,3RD FLOOR,BANGALORE PHONE- 080-41224536 CONTACT PERSON- MR. HUZEFA PAVTHIWALA FYRE MASQ AGENCIES 52/7, HAINES ROAD , ANGALORE PHONE – 080-5512895/5369689 CONTACT PERSON – MR. BERNARD HEREFORD CELL - 9844060835 GARUDA FIRE SERVICES 1ST CROSS, SUBBAYANA PALYA, MS NAGAR POST, BANGALORE – 33 PHONE - 08025455633
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19. EMERGENCY TRANSPORT FACILITY
Company has two vehicles at any point of time and service of Ambulance for emergency transport system. Additional ambulances can be arranged for transportation from nearby hospitals and mutual aid partners.
31 Bommasandra 20. CONTROL ROOM
EMERGENCY CONTACTS LIST
COMMUNICATION NOs (INTERNAL AND EXTERNAL AGENCIES) SL SECTION /NAME PHONE NUMBERS NO 1 DEPUTYCOMMISSIONER 080-22255344,22867221/988070071 CENTRAL 2 SUPERITENDENT OF POLICE Anekal police—7859335/9480802435
3 POLICE 100, Police control room Anekal—7859235
4 FIRE SERVICES 102, 108, (Dairy circle/electronic city)— 22971576/2942999
5 HOSPITALS Jigani ESI—9141829117 Suhas Hospital - 6 OCCUPIER/MANAGERS Mr.Krishna Rao
7 DIRECTORATE OF FACTORIES AND 080-26531200 BOILERS 8 KARNATAKA STATE POLLUTION 080-25589112,25581383,25586520 BOARD 9 KEY PERSONNEL OF THE INDUSTRY Mr.Krishna Rao
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21. ALERT ACTION PLAN DURING WORKING/NON WORKING HOURS
Fire /other exigencies
Discoverer communicates byphone or personally to the security gate
Security Supervisor activates the emergency siren (15 seconds ON and 05 OFF for 3 timesand communicates to Factory
Incident Controller(shift supervisor) Dispatch the fire fighting team to the rushes to the spot spot
Alert the employees thro’ Public Address System for evacuation If it is controllable, isolate the area & do fire fighting
Ensure the Evacuation of the people from work spots. If it is uncontrollable shutdown all the process and evacuate the area & ensure the fire agencies arrive at the spot & Arrange fire brigade /first aid/ fire is extinguished Ambulance
Prevent unauthorized people entering into the company
Head count / Assembly Point / First Aid
“All Clear” siren to be activated by the Security Supervisor after confirming with the site controller
33 Bommasandra 22. EMERGENMCY ORGANIZATION CHART
SITE CONTROLLER Leading emergency Coordinators
COORDINATOR COORDINATOR COORDINATOR – COORDINATOR COORDINATOR – Law & Order & Govt. Hospitals & Fire Head count & Communication Rescue coordination agencies brigade Information to Relatives
RESCUE OPERATION
RESCUE MEMBERS
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23. ON SITE EMERGENCY PLANNING
SCOPE OF ONSITE EMERGENCY PLAN
The scope of the plan is to ensure safety of life, protection of environment and protection of property. Although the emergency may be caused by different factors such as natural calamity, civil disturbance, sabotage, equipment failure, human error, it is normally manifest in the form of fire.
ONSITE EMERGENCY
Major emergency is one which may or may not cause material damage or injury but likely to have an impact on the entire operation of the factory. Such an emergency may be controlled using resources within the factory and resources available in the surrounding establishments.
OBJECTIVES OF ONSITE EMERGENCY PLAN
– To Localize the emergency and if possible eliminate – To Control and contain the incident as early as possible. – To safeguard other employees by evacuating them to safe assembly points. – To minimize the damage to the plant and material and to limit environment pollution. – To rescue accident victims and organize medical treatment. – To re-establish normal connections. Preserve relevant records and equipment for the subsequent enquiry into the cause and circumstances of the emergency.
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23.1. ESTABLISH LINE OF CONTROL-RESPONSIBILITY & ALTERNATIVE LINE OF CONTROL
NO LINE OF CONTROLLER MAIN ALTERNATE AFETR ALTERNATE OFFICE HRS 1. SITE CONTROLLER VP AGM-O SHIFT SHIFT Leading emergency OPERATIONS. INCHARGE CHEMIST coordinators 2. INCIDENT SR. MANAGER PROD. PROD. JR. CONTROLLER MANAGER EXECUTIVE EXECUTIVE PROD. Law & Order & Govt. agencies
3. CO-ORDINATOR – MANAGER- EXECUTIVE- QC- QC- HEAD COUNT ADMN ADMN CHEMIST CHEMIST
4. CO-ORDINATOR-LAW MANAGER-HR EXECUTIVE- SEC- SEC- AND ORDER. HR INCHARGE OFFICER
5. CO-ORDINATOR- HR OFFICER- SEC- SEC- HOSPITAL/TRANSPORT OFFICER -ADMN INCHARGE OFFICER.
6. FIRST AID. OFFICER-OHC OHC- SAFETY SAFETY- CO-ORDINATOR ASSISTANT SQAUD SQUAD
7. CO-ORDINATOR- MAINTENANCE ENGR- SHIFT PLANT- MAINT. MANAGER- MAINT. INCHARGE MECHANIC
8. CO-ORDINATOR- ENGR-UTILITY MECHANIC- SHIFT PLANT HYDRANT UTLITY INCHARGE MECHANIC
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23.3. ROLE AND RESPONSIBILITY IN BRIEF
1.ANY PERSON NOTICING DANGEROUS SITUATION SHOULD ALERT THE PERSONNEL AROUND & REPORT IMMEDIATELY TO THE HOD (OR) HIS DEPUTY.
2.HOD (OR) HIS DEPUTY AFTER ASSESSING THE SITUATION SHOULD ACTIVATE MANUAL CALL POINT (MCP) OF EMERGENCY SIREN.
3.MANUAL CALL POINT (MCP) SHOULD NOT BE ACTIVATED, OTHER THAN EMERGENCY.
4. THE DEPT. HEAD/DEPUTY SHOULD ASSURE & TAKE THE ROLE OF INCIDENT CONTROLLER.
5. IN THE ABSENCE OF SITE CONTROLLER, SECURITY HEAD SHOULD ASSURE & TAKE THE ROLE OF THE CONTROLLER.
6. IN THE ABSENCE OF INCIDENT CONTROLLER, THE SENIOR MOST PERSON AVAILABLE IN THE SHIFT OF CONCERN DEPARTMENT SHOULD ASSURE & TAKE THE ROLE OF INCIDENT CONTROLLER.
ROLE & RESPONSIBILITY OF OTHER HODS DURING EMERGENCIES
1. BRING DOWN OPERATIONS TO SAFE LEVEL & AWAIT EVACUATION CALL.
2. SEND DEPARTMENT ERT MEMBER TO THE SITE OF INCIDENT.
3. LEAD THE STAFF IN ORDERLY MANNER TO THE SAFE ASSEMBLY POINT.
4. TAKE THE HEAD COUNT AND HANDOVER IT TO THE EC-3 (SECURITY OFFICER)
5. STAY CALM, TILL THE CLEAR INFORMATION IS COMMUNICATED.
6. BE READY FOR HELP, IN CASE IT IS CALLED FOR.
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23.4 &5. NOTIFICATIONS AND DECLARATION OF EMERGENCY a) Soon after noticing fire or gas leak or any hazard, the first observer shall start efforts to extinguish the fire or to arrest the gas leak or to stop any hazard from escalating, at the same time makes arrangements to break MCP to activate the hooter. b) The concerned incident controller will immediately report to the site and takes over the control operations. The Safety Head / Incident Controller handling the incident require extra assistance from the Site Controller / Unit Head who shall declare an ‘On Site Emergency’ by calling for evacuation. Evacuation Siren: The siren will be sounded continuously for 3 minutes waxing and waning for 5 seconds and 10 seconds respectively.
23.6. EVACUATION OF PERSONNEL Upon hearing the SIREN for evacuation, the department head will lead the staff and the workmen in the department to the designated assembly point observing wind direction for safe path and proceed in orderly manner.
23.7. ACCOUNTING OF PERSONNEL Upon hearing the SIREN for evacuation, the emergency co-ordinator head count will proceed to assembly point to collect head counts of various departments including contractors/ transporters/ visitors and the same is compared with the master list to identify missing personnel. The names of missing personnel are conveyed to site controller to start rescue operation.
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23.8. CONTROLLING OF EMERGENCY
Soon after noticing fire or gas leak or any hazard, the first observer shall start efforts toextinguish the fire or to arrest the gas leak or to stop any hazard from escalating, at the same time makes arrangements to break MCP to activate the hooter.
The concerned incident controller will immediately report to the site and takes over the control operations.
In the mean time the safety squad will arrive at the scene with extinguishers or any safety equipment and report to incident controller.
With the help of safety squad and emergency co-ordinator of Engineering-Utility, the incident controller brings other operations in the department to safe level and makes effort to stop the fire or gas leak or any hazardous situation.
23.9. ARRANGEMENTS FOR MEDICAL TREATMENT
The injured will be rendered First Aid at OHC, and if required will be sent to Hospital wherein we have a tie-up for treatment. Further any specialty treatment is required as per the advise of the doctor, will be taken to the hospitals. The list of the hospitals and contact numbers are listed in important telephone numbers.
23.10. INFORMATION TO THE RELATIVES OF THE INJURED
The relatives of injured will be informed by emergency co-ordinator Liaison and communication. The Employees residential address file will be available at emergency control center and as a part of Onsite emergency plan. The communications to the relatives of injured will be passed on through telecom or by a messenger with a car. The clear address of the injured person (Local residential address, address if hospitalized) will be communicated to his relatives, by the coordinator liaison and communication.
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23.11. INFORMATION TO THE GOVERNMENT AUTHORITIES
The emergency co-ordinator (Services & Communication) is authorized to inform to the police. The inspector of police Bannerughatta Police Station will be informed for the control of law & order situation at the plant vicinity or at hospital where injured are under treatment. The communication will be made to the Deputy Superintendent of police of Bangalore also. Police Department will be requested for protecting the lives of the employees and the property of the employees, control of the traffic, arranging for evacuation of personnel outside the plant. Deputy Commissioner and superintendent of police, Bangalore also will be informed regarding emergency.
23.12. LAW AND ORDER
THE INFORMATION REGARDING EMERGENCY IS SET TO GOVERNMENT AUTHORITIES/GENERAL PUBLICE BY THE Declarer/Controller of emergency to ensure LAW AND ORDER SITUATION IS FULLY UNDER THE CONTROL Deputy Commissioner -- 08025567085 Additional Commissioner of police -- 080- 22255262 Police station --- general – 100
23.13. ALL CLEAR SIGNAL
After the situation is brought under control the emergency will be called off by incident controller. Once the emergency is called off, the detailed inspection is conducted by emergency organizing personnel on their satisfaction of the situation. The site controller will give clearance to resume the plant operations.
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SL NO PRODUCT PAGE NO. 1 METHANOL 45-48 2 DIMETHYL FORMAMIDE 55-60 3 MMETHYL VINYL PHOSPHATE
4 HYDROGEN
5 MEROPENEM SIDE CHAIN 6 ETHYL DIISOPROPYL AMINE
7 POTASSIEM DIHYDROGEN PHOSPHATE
8 TETRAHYDROFURAN
9 MORPHOLINO PROPANE SULPHONIC ACID 10 METHELENE DI CHLORIDE
11 CARBON
12 METHANOLIC AMMONIA
13 ACETONE
14 Pd/c WET 50%
15 HYDROCHLORIC ACID
16 FORMIC ACID
17 WATER FOR INJECTION
18 MEROPENEM NS
19 SODIUM CARBONATE
20 N- METHYL PYROLIDONONE
21 THIENA CYCLIC
22 METHYLENE DI CHLORIDE
23 CYSTAMINE HCL
24 DIPHENYL CHLORO PHOSPHATE 25 ACETONITRILE
26 BENZYLE FORMAMIDATE
41 Bommasandra 27 AB ALCOHOL
28 SODIUM CHLORIDE
29 SODIUM METHOXIDE
30 CILA ACID
31 HYFLO
32 SODIUM BI CARBONATE
33 CARBONDI OXIDE 34 ERTAPENEM SIDECHAIN
35 CYCLIC BASE
36 PHOSPHORIC ACID
37 n-PROPANOL
38 CILASTAIN ACID
39 SOD.-2 ETHYL HEXONATE
40 PANIPENEM SIDE CHAIN
41 DORIPENEM SIDE CHAIN
42 SILLYL FAROPENEM SIDE CHAIN PNB
43 SILLYL SULOPENEM ALLYL
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PRODUCT: METHANOL 1. Product Identification Synonyms: Wood alcohol; methanol; carbinol CAS No.: 67-56-1 Molecular Weight: 32.04 Chemical Formula: CH3OH 2. Composition
Ingredient CAS No Percent Hazardous ------
Methyl Alcohol 67-56-1 100% Yes 3. Hazards Identification
Emergency Overview POISON! DANGER! VAPOR HARMFUL. MAY BE FATAL OR CAUSE BLINDNESS IF SWALLOWED. HARMFUL IF INHALED OR ABSORBED THROUGH SKIN. CANNOT BE MADE NONPOISONOUS. FLAMMABLE LIQUID AND VAPOR. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AFFECTS CENTRAL NERVOUS SYSTEM AND LIVER. Health Rating: 3 - Severe (Poison) Flammability Rating: 3 - Severe (Flammable) Reactivity Rating: 1 - Slight Contact Rating: 3 - Severe (Life) Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES; CLASS B EXTINGUISHER Storage Color Code: Red (Flammable) Potential Health Effects Inhalation: A slight irritant to the mucous membranes. Toxic effects exerted upon nervous system, particularly the optic nerve. Once absorbed into the body, it is very slowly eliminated. Symptoms of overexposure may include headache, drowsiness, nausea, vomiting, blurred vision, blindness, coma, and death. A person may get better but then worse again up to 30 hours later. Ingestion: Toxic. Symptoms parallel inhalation. Can intoxicate and cause blindness. Usual fatal dose: 100-125 milliliters. Skin Contact: Methyl alcohol is a defatting agent and may cause skin to become dry and cracked. Skin absorption can occur; symptoms may parallel inhalation exposure. Eye Contact: Irritant. Continued exposure may cause eye lesions. Chronic Exposure: Marked impairment of vision has been reported. Repeated or prolonged exposure may cause skin irritation. Aggravation of Pre-existing Conditions: Persons with pre-existing skin disorders or eye problems or impaired liver or kidney function may be more susceptible to the effects of the substance. 4. First Aid Measures Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention immediately. Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
43 Bommasandra Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately. 5. Fire Fighting Measures Fire: Flash point: 12C (54F) CC Autoignition temperature: 464C (867F) Flammable limits in air % by volume: lel: 6.0; uel: 36 Flammable Liquid and Vapor! Explosion: Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Moderate explosion hazard and dangerous fire hazard when exposed to heat, sparks or flames. Sensitive to static discharge. Fire Extinguishing Media: Use alcohol foam, dry chemical or carbon dioxide. (Water may be ineffective.) Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. Use water spray to blanket fire, cool fire exposed containers, and to flush non-ignited spills or vapors away from fire. Vapors can flow along surfaces to distant ignition source and flash back. 6. Accidental Release Measures Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Use non-sparking tools and equipment. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer! If a leak or spill has not ignited, use water spray to disperse the vapors, to protect personnel attempting to stop leak, and to flush spills away from exposures. US Regulations (CERCLA) require reporting spills and releases to soil, water and air in excess of reportable quantities. The toll free number for the US Coast Guard National Response Center is (800) 424-8802. 7. Handling and Storage Protect against physical damage. Store in a cool, dry well-ventilated location, away from any area where the fire hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfers to avoid static sparks. Storage and use areas should be No Smoking areas. Use non-sparking type tools and equipment, including explosion proof ventilation. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product. Do Not attempt to clean empty containers since residue is difficult to remove. Do not pressurize, cut, weld, braze, solder, drill, grind or expose such containers to heat, sparks, flame, static electricity or other sources of ignition: they may explode and cause injury or death. 8. Exposure Controls, Personal Protection Airborne Exposure Limits: For Methyl Alcohol: - OSHA Permissible Exposure Limit (PEL):200 ppm (TWA) - ACGIH Threshold Limit Value (TLV):200 ppm (TWA), 250 ppm (STEL) skin Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details. Use explosion-proof equipment. Personal Respirators (NIOSH Approved): If the exposure limit is exceeded and engineering controls are not feasible, wear a supplied air, full-facepiece respirator, airlined hood, or full-facepiece self-contained breathing apparatus. Breathing air quality must meet the requirements of the OSHA respiratory protection standard (29CFR1910.134). This substance has poor warning properties. Skin Protection: Rubber or neoprene gloves and additional protection including impervious boots, apron, or coveralls, as needed in
44 Bommasandra areas of unusual exposure. Eye Protection: Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area. 9. Physical and Chemical Properties Appearance: Clear, colorless liquid. Odor: Characteristic odor. Solubility: Miscible in water. Specific Gravity: 0.8 pH: No information found. % Volatiles by volume @ 21C (70F): 100 Boiling Point: 64.5C (147F) Melting Point: -98C (-144F) Vapor Density (Air=1): 1.1 Vapor Pressure (mm Hg): 97 @ 20C (68F) Evaporation Rate (BuAc=1): 5.9 10. Stability and Reactivity Stability: Stable under ordinary conditions of use and storage. Hazardous Decomposition Products: May form carbon dioxide, carbon monoxide, and formaldehyde when heated to decomposition. Hazardous Polymerization: Will not occur. Incompatibilities: Strong oxidizing agents such as nitrates, perchlorates or sulfuric acid. Will attack some forms of plastics, rubber, and coatings. May react with metallic aluminum and generate hydrogen gas. Conditions to Avoid: Heat, flames, ignition sources and incompatibles. 11. Toxicological Information Methyl Alcohol (Methanol) Oral rat LD50: 5628 mg/kg; inhalation rat LC50: 64000 ppm/4H; skin rabbit LD50: 15800 mg/kg; Irritation data-standard Draize test: skin, rabbit: 20mg/24 hr. Moderate; eye, rabbit: 100 mg/24 hr. Moderate. Investigated as a mutagen, reproductive effector. ---NTP Carcinogen--- Ingredient Known Anticipated IARC Category ------Methyl Alcohol (67-56-1) No No None 12. Ecological Information
Environmental Fate: When released into the soil, this material is expected to readily biodegrade. When released into the soil, this material is expected to leach into groundwater. When released into the soil, this material is expected to quickly evaporate. When released into the water, this material is expected to have a half-life between 1 and 10 days. When released into water, this material is expected to readily biodegrade. When released into the air, this material is expected to exist in the aerosol phase with a short half-life. When released into the air, this material is expected to be readily degraded by reaction with photochemically produced hydroxyl radicals. When released into air, this material is expected to have a half-life between 10 and 30 days. When released into the air, this material is expected to be readily removed from the atmosphere by wet deposition. Environmental Toxicity: This material is expected to be slightly toxic to aquatic life 13. Disposal Considerations .Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved incinerator or disposed in a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
45 Bommasandra 14. Transport Information Domestic (Land, D.O.T.) Proper Shipping Name: METHANOL Hazard Class: 3 UN/NA: UN1230 Packing Group: II Information reported for product/size: 358LB International (Water, I.M.O.) Proper Shipping Name: METHANOL Hazard Class: 3, 6.1 UN/NA: UN1230 Packing Group: II Information reported for product/size: 358LB 15. Regulatory Information
Ingredient TSCA EC Japan Australia ------Methyl Alcohol (67-56-1) Yes YesYesYes
--Canada-- Ingredient Korea DSL NDSL Phil. ------Methyl Alcohol (67-56-1) Yes Yes No Yes
Ingredient RQ TPQ List Chemical Catg. ------Methyl Alcohol (67-56-1) No No Yes No
-RCRA- -TSCA- Ingredient CERCLA 261.33 8(d) ------Methyl Alcohol (67-56-1) 5000 U154 No
16. Other Information NFPA Ratings: Health: 1 Flammability: 3 Reactivity: 0 Label Hazard Warning: POISON! DANGER! VAPOR HARMFUL. MAY BE FATAL OR CAUSE BLINDNESS IF SWALLOWED. HARMFUL IF INHALED OR ABSORBED THROUGH SKIN. CANNOT BE MADE NONPOISONOUS. FLAMMABLE LIQUID AND VAPOR. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AFFECTS CENTRAL NERVOUS SYSTEM AND LIVER.
46 Bommasandra
PRODUCT:N, N-Dimethylformamide, 99%
Section 1 - Chemical Product and Company Identification
MSDS Name: N,N-Dimethylformamide, 99% Synonyms: N,N-Dimethylmethanamide; DMF; DMFA.
Section 2 - Composition, Information on Ingredients
CAS# Chemical Name Percent EINECS/ELINCS 68-12-2 N,N-Dimethylformamide 99 200-679-5
Section 3 - Hazards Identification Hazard Symbols: T Risk Phrases: 20/21 36 61 EMERGENCY OVERVIEW Appearance: clear, colorless liquid. Flash Point: 57 deg C. Warning! Causes respiratory tract irritation. May cause digestive tract irritation with nausea, vomiting, and diarrhea. Causes eye and skin irritation. This substance has caused adverse reproductive and fetal effects in animals. May cause liver and kidney damage. Combustible liquid and vapor. Potential cancer hazard. Target Organs: Kidneys, liver. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause liver damage. Inhalation: Causes respiratory tract irritation. Chronic: Possible cancer hazard based on tests with laboratory animals. Prolonged or repeated skin contact may cause dermatitis. May cause reproductive and fetal effects. Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical experts. Section 4 - First Aid Measures personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Getmedical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration usingoxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: Treat symptomatically and supportively. General Information: As in any fire, wear a self -contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Flash Point: 57 deg C ( 134.60 deg F) Autoignition Temperature: 445 deg C ( 833.00 deg F) Explosion Limits, Lower:2.2 Upper: 15.2 NFPA Rating: (estimated) Health: 2; Flammability: 2; Instability: 0 General Information: Use proper personal protective equipment as indicated in Section 8.
47 Bommasandra Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Donot flush into a sewer. Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition.Provide ventilation. Exposure Limits OSHA Vacated PELs: N,N-Dimethylformamide: 10 ppm TWA; 30 mg/m3 TWASection Section 5 - Fire Fighting Measures Extinguishing Media: Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - Accidental Release Measures During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep Bfire-exposed containers cool. Combustible Liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated. Section 7 - Handling and Storage Handling: Wash thoroughly after handling. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not ingest or inhale. Use with adequate ventilation. Do not pressurize,cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Section 8 - Exposure Controls, Personal Protection Chemical Name ACGIH NIOSH OSHA - Final PELs N,N-Dimethylformamide 10 ppm TWA; skin - potential for cutaneous absorption 10 ppm TWA; 30 mg/m3 TWA 500 ppm IDLH 10 ppm TWA; 30 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. CAS# 68-12-2: LQ2100000 LD50/LC50: CAS# 68-12-2: Inhalation, mouse: LC50 = 9400 mg/m3/2H; Oral, mouse: LD50 = 2900 mg/kg; Oral, rabbit: LD50 = 5 gm/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = 4720 mg/kg; Section 9 - Physical and Chemical Properties Physical State: Liquid Appearance: clear, colorless Odor: Faint, amine odor. pH: 6 - 8 @ 20% aq.sol. Vapor Pressure: 4.9 mbar @ 20 C Vapor Density: 2.5 (air=1) Evaporation Rate:0.17 (butylacetate=1) Viscosity: 0.8 mPas @ 20 C
48 Bommasandra Boiling Point: 153 deg C Freezing/Melting Point:61 deg C Decomposition Temperature:Not available. Solubility: Completely soluble in water. Specific Gravity/Density:0.9450 Molecular Formula:C3H7NO Molecular Weight:73.0551 Section 10 - Stability and Reactivity Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Mechanical shock, incompatible materials, ignition sources, excess heat, temperatures above 55°C. Incompatibilities with Other Materials: Carbontetrachloride, violent reaction with halogens, iron, oxidizing materials, chlorinated hydrocarbons, isocyanates, nitrates, organic materials, phenols, ammonia, anhydrides. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - Toxicological Information ACGIH: A4 - Not Classifiable as a Human Carcinogen IARC: IARC Group 3 - not classifiable Epidemiology: Experimental reproductive effects have been reported. Teratogenicity: No information available. Reproductive Effects: Similar compounds have shown reproductive effects. Neurotoxicity: No information available. Mutagenicity: Reported non-mutagenic in a large number of assays using whole animals, cultured mammalian cells, yeast and bacteria; including dominant lethal tests in rats, micronucleus test and sperm abnormality test. Other Studies: See actual entry in RTECS for complete information. Ecotoxicity: No data available. Damage to fish: Gold oland test: 18 hrs LC50: 500 mg/l Environmental: DMF is expected to biodegrade rapidly in the environment and should be highly mobile in soil. In aquatic systems, DMF is not expected to partition from the water column to organic matter contained in sediments and suspended solids or bioconcentrate in aquatic organisms. Physical: The vapor-phase reaction with photochemically produced hydroxyl radicals (half-life of 2 hours) is likely to be an important fate process. Section 12 - Ecological Information
Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. Section 14 - Transport Information US DOT IATA RID/ADR IMO Shipping Name: N,NDIMETHYLFORMAMIDE Hazard Class: 3 UN Number: UN2265 Packing Group: III Section 15 - Regulatory Information TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. SARA CERCLA Hazardous Substances and corresponding RQs CAS# 68-12-2: 100 lb final RQ; 45.4 kg final RQ SARA Section 302 Extremely Hazardous Substances None of the chemicals in this product have a TPQ.
49 Bommasandra SARA Codes CAS # 68-12-2: acute, flammable. Section 313 This material contains N,N-Dimethylformamide (CAS# 68-12-2, 99%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. Clean Air Act: CAS# 68-12-2 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed asToxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. Section 16 - Additional Information The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.
50 Bommasandra
PRODUCT: Hydrogen
1. Product Identification PRODUCT NAME: Hydrogen, compressed CHEMICAL NAME: Hydrogen FORMULA: H2 SYNONYMS: None 2. Composition Hydrogen is sold as pure product >99% CAS NUMBER:1333-74-0 EXPOSURE LIMITS: OSHA: None ACGIH: Simple asphyxiant 3. Hazards Identification Hydrogen is a flammable, colorless, odorless, compressed gas packaged in cylinders at high pressure. It poses an immediate fire and explosive hazard when concentrations exceed 4%. It is much lighter than air and burns with an invisible flame. High concentrations that will cause suffocation are within the flammable range and must not be entered. 4. First Aid Measures INHALATION: Asphyxiant. It should be noted that before suffocation could occur, the lower flammability limit of hydrogen in air would be exceeded possibly causing both an oxygen-deficient and explosive atmosphere. Exposure to moderate concentrations may cause dizziness, headache, nausea and unconsciousness. Exposure to atmospheres containing 8-10% or less oxygen will quickly bring about unconsciousness without warning leaving individuals unable to protect themselves. Lack of sufficient oxygen may cause serious injury or death. EYE CONTACT: None SKIN CONTACT: None CHRONIC EFFECTS: None OTHER EFFECTS OF OVEREXPOSURE: None EXPOSURE INFORMATION: ROUTE OF ENTRY: Inhalation TARGET ORGANS: None EFFECT: Asphyxiation (suffocation) SYMPTOMS: Exposure to an oxygen-deficient atmosphere (<19.5%) may cause dizziness, drowsiness, nausea, vomiting, excess salivation, diminished mental alertness, loss of consciousness, and death. MEDICAL CONDITIONS AGGRAVATED BY OVEREXPOSURE: None CARCINOGENIC POTENTIAL: Hydrogen is not listed by NTP, OSHA or IARC.. 5. Fire Fighting Measures FLAMMABLE LIMITS: Flammable gas 565.5_C (1050_F) LOWER: 4% UPPER: 74% EXTINGUISHING MEDIA: CO2, dry chemical, water spray or fog for surrounding area. Do not extinguish until hydrogen source is shut off. HAZARDOUS COMBUSTION PRODUCTS: None SPECIAL FIRE FIGHTING INSTRUCTIONS: Evacuate all personnel from danger area. Immediately cool container with water spray from maximum distance, taking care not to extinguish flames. If flames are accidentally extinguished, explosive re-ignition may occur. Stop flow of gas if without risk while continuing cooling water spray. UNUSUAL FIRE AND EXPLOSION HAZARDS: Burns with a pale blue, nearly invisible flame. Hydrogen is easily ignited with low-ignition energy, including static electricity. Hydrogen is lighter than air and can accumulate in the upper sections of enclosed spaces. Pressure in a container can build up due to heat, and it may rupture if pressure relief devices should fail to function. 6. Accidental Release Measures
51 Bommasandra Evacuate immediate area. Eliminate any possible sources of ignition, and provide maximum explosion- proof ventilation. Shut off source of hydrogen, if possible. If leaking from cylinder, or valve, call the Air Products' emergency phone number. The presence of a hydrogen flame can be detected by approaching cautiously with an outstretched straw broom to make the flame visible.
7. Handling and Storage Specific requirements are listed in NFPA 50A. Cylinder storage locations should be well- protected, well-ventilated, dry, and separated from combustible materials. Cylinders should never knowingly be allowed to reach a temperature exceeding 125 _F (52 _C). Cylinders of hydrogen should be separated from oxygen cylinders or other oxidizers by a minimum distance of 20 ft., or by a barrier of noncombustible material at least 5 ft. high having a fire resistance rating of at least _ hour. Cylinders should be stored upright with valve protection cap in place and firmly secured to prevent falling or being knocked over. Protect cylinders from physical damage; do not drag, roll, slide or drop. Use a suitable hand truck for cylinder movement. Post "No Smoking or Open Flames" signs in the storage areas. There should be no sources of ignition. All electrical equipment should be explosion proof in the storage and use areas. Storage areas must meet national electric codes for class 1 hazardous areas. HANDLING: Do not "open" hydrogen cylinder valve before connecting it, since self-ignition may occur. Hydrogen is the lightest gas known and may collect in the top of buildings with out proper ventilation. It may leak out of a system which is gas-tight for air or other gases. Leak check system with leak detection solution, never with flame. If user experiences difficulty operating cylinder valve, discontinue use and contact supplier. Use only approved CGA connections. DO NOT USE ADAPTERS. Never insert an object (e.g., wrench, screwdriver, pry bar, etc.) into valve cap openings. Doing so may damage valve, causing a leak to occur. Use an adjustable strap wrench to remove over- tight or rusted caps. Never strike an arc on a compressed gas cylinder or make a cylinder a part of an electrical circuit. SPECIAL PRECAUTIONS: Use piping and equipment adequately designed to withstand pressures to be encountered. Use a check valve or other protective apparatus in any line or piping from the cylinder to prevent reverse flow. 8. Exposure Controls, Personal Protection ENGINEERING CONTROLS: Provide natural or explosion-proof ventilation adequate to ensure hydrogen does not reach its lower explosive limit of 4%. RESPIRATORY PROTECTION: General Use: None Emergency Use: Air supplied respirators are required in oxygen-deficient atmospheres. Before entering area you must check for flammable or oxygen-deficient atmospheres. PROTECTIVE GLOVES: Work gloves are recommended when handling cylinders. EYE PROTECTION: Safety glasses are recommended when handling cylinders. OTHER PROTECTIVE EQUIPMENT: Safety shoes are recommended when handling cylinder 9. Physical and Chemical Properties APPEARANCE AND STATE: Colorless gas at normal temperature and pressure. ODOR: Odorless MOLECULAR WEIGHT: 2.016 BOILING POINT (1 atm) : -423.0 _F (-252.8 _C) SPECIFIC GRAVITY (Air =1) : 0.06960 FREEZING POINT/MELTING POINT: -434.5 °F (-259.2 _C) VAPOR PRESSURE (at 70 F): Not applicable GAS DENSITY (At 70 F (21.1 C) and 1 atm) : 0.00521 lb/ft 3 (0.08342 kg/m 3 ) SOLUBILITY IN WATER (Vol/Vol at 60 F (15.6 C)) : 0.019 SPECIFIC VOLUME (At 70 F (21.1 C) and 1 atm) : 192 ft 3/lb (11.99m 3/kg) 10. Stability and Reactivity CHEMICAL STABILITY: Stable CONDITIONS TO AVOID: None INCOMPATIBILITY (Materials to Avoid): Oxidizing agents. Some steels are susceptible to hydrogen embrittlement at high pressures and temperatures. REACTIVITY: A) HAZARDOUS DECOMPOSITION PRODUCTS: None B) HAZARDOUS POLYMERIZATION: Will not occur. 11. Toxicological Information Hydrogen is a simple asphyxiant 12. Ecological Information
52 Bommasandra No adverse ecological effects are expected. Hydrogen does not contain any Class I or Class II ozone depleting chemicals (40 CFR Part 82). Hydrogen is not listed as a marine pollutant by DOT (49 CFR Part 171). 13. Disposal Considerations DISPOSAL METHOD: Do not attempt to dispose of residual or unused product in the cylinder. Return to supplierfor safe disposal. Residual product within process system may be vented at a controlled rate, to the atmosphere through a vent stack that discharges to an elevated point. This stack should be in an isolated area away from ignition sources. 14. Transport Information SHIPPING NAME: Hydrogen, compressed HAZARD CLASS: 2.1 (Flammable Gas) IDENTIFICATION NUMBER: UN1049 PRODUCT RQ: None SHIPPING LABEL(s): Flammable gas. PLACARD (When required): Flammable gas. SPECIAL SHIPPING INFORMATION: Cylinder should be transported in a secure upright position in a well ventilated truck. NEVER TRANSPORT IN PASSENGER COMPARTMENT OF A VEHICLE. Shipment of compressed gas cylinders which have not been filled with the owner's consent is a violation of Federal law (49 CFR Part 173.301 (b)). 15. Regulatory Information FEDERAL REGULATIONS: EPA - ENVIRONMENTAL PROTECTION AGENCY CERCLA: Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (40 CFR Parts 117 and 302): Reportable Quantity (RQ): None SARA: Superfund Amendment and Reauthorization Act SECTION 302/304: Requires emergency planning on threshold planning quantities (TPQ) and release reporting based on reportable quantities (RQ) of EPA's extremely hazardous substances (40 CFR Part 355). Extremely Hazardous Substances: None Threshold Planning Quantity (TPQ): None SECTIONS 311/312: Require submission of material safety data sheets (MSDSs) and chemical inventory reporting with identification of EPA defined hazard classes (40 CFR Part 370). The hazard classes for this product are: IMMEDIATE: No PRESSURE: Yes DELAYED: No REACTIVITY: No FLAMMABLE: Yes SECTION 313: Requires submission of annual reports of release of toxic chemicals that appear in 40 CFR Part 372. Hydrogen does not require reporting under Section 313 40 CFR PART 68: Risk Management for Chemical Accidental Release. Requires the development and implementation of risk management programs at facilities that manufacture, use, store, or otherwise handle regulated substances in quantities that exceed specified thresholds. Hydrogen is not listed as a regulated substance. However, any process that involves a flammable gas on site in one location, in quantities of 10,000 pounds (4,553 kg) or greater, is covered under this regulation. TSCA: Toxic Substance Control Act: Hydrogen is listed on the TSCA inventory. OSHA - OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION: 29 CFR 1910.119: 16. Other Information OTHER INFORMATION: NFPA RATINGS: HMIS RATINGS: HEALTH: = 0 HEALTH: = 0 FLAMMABILITY: = 4 FLAMMABILITY: = 4 REACTIVITY: = 0 REACTIVITY: = 0 SPECIAL: = SA (CGA recommends this to designate simple asphyxiant)
53 Bommasandra
PRODUCT: Ethyl alcohol
Section 1: Chemical Product and Company Identification
Product Name: Ethyl alcohol 200 Proof
CAS#: 64-17-5
Synonym: Ethanol; Absolute Ethanol; Alcohol; Ethanol
Ethyl Alcohol, Anhydrous; Ethanol, undenatured;
Dehydrated Alcohol; Alcohol
Chemical Name: Ethyl Alcohol
Chemical Formula: CH3CH2OH Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Ethyl alcohol 200 Proof 64-17-5 100
Toxicological Data on Ingredients: Ethyl alcohol 200 Proof: ORAL (LD50): Acute: 7060 mg/kg [Rat]. 3450 mg/kg [Mouse].
VAPOR (LC50): Acute: 20000 ppm 8 hours [Rat]. 39000 mg/m 4 hours [Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects:
Hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Slightly hazardous in case of skin contact
(permeator), of ingestion.
Potential Chronic Health Effects:
Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
TERATOGENIC EFFECTS: Classified PROVEN for human. DEVELOPMENTAL TOXICITY: Classified Development toxin [PROVEN]. Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE]. The substance is toxic to blood, the reproductive system, liver, upper respiratory tract, skin, central nervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage.
54 Bommasandra
Section 4: First Aid Measures
Eye Contact: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.
Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to- mouth resuscitation. Seek medical attention.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: 363°C (685.4°F)
Flash Points: CLOSED CUP: 12.78°C (55°F). OPEN CUP: 17.78°C (64°F) (Cleveland).
Flammable Limits: LOWER: 3.3% UPPER: 19%
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:
Highly flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizing materials.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of open
55 Bommasandra flames and sparks, of heat, of oxidizing materials, of acids.
Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog.
Special Remarks on Fire Hazards:Containers should be grounded. CAUTION: MAY BURN WITH NEAR INVISIBLE FLAME Vapor may travel considerable distance to source of ignition and flash back. May form explosive mixtures with air. Contact with Bromine pentafluoride is likely to cause fire or explosion. Ethanol ignites on contact with chromyl chloride. Ethanol ignites on contact with iodine heptafluoride gas. It ignites than explodes upon contact with nitrosyl perchlorate. Additon of platinum black catalyst caused ignition.
Special Remarks on Explosion Hazards:
Ethanol has an explosive reaction with the oxidized coating around potassium metal. Ethanol ignites and then explodes on contact with acetic anhydride + sodium hydrosulfate (ignites and may explode), disulfuric acid + nitric acid, phosphorous(III) oxide platinum, potassium-tert-butoxide+ acids. Ethanol forms explosive products in reaction with the following compound :
Section 6: Accidental Release Measures
Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.
Section 7: Handling and Storage
Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids, alkalis, moisture.
Storage: Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Do not store above 23°C (73.4°F).
Section 8: Exposure Controls/Personal Protection
Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection: Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Use a respirator if the exposure limit is exceeded.
56 Bommasandra Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.
Exposure Limits: TWA: 1900 (mg/m3) from OSHA (PEL) [United States] TWA: 1000 (ppm) from OSHA (PEL) [United States] TWA: 1900 (mg/ m3) from NIOSH [United States] TWA: 1000 (ppm) from NIOSH [United States] TWA: 1000 (ppm) [United Kingdom (UK)]
TWA: 1920 (mg/m3) [United Kingdom (UK)] TWA: 1000 STEL: 1250 (ppm) [Canada]Consult local authorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid. (Liquid.)
Odor:Mild to strong, rather pleasant; like wine or whiskey. Alcohol-like; Ethereal, vinous.
Taste: Pungent. Burning.
Molecular Weight: 46.07 g/mole
Color: Colorless. Clear pH (1% soln/water): Not available.
Boiling Point: 78.5°C (173.3°F)
Melting Point: -114.1°C (-173.4°F)
Critical Temperature: 243°C (469.4°F)
Specific Gravity: 0.789 (Water = 1)
Vapor Pressure: 5.7 kPa (@ 20°C)
Vapor Density: 1.59 (Air = 1)
Volatility: Not available.
Odor Threshold: 100 ppm
Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.3
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, methanol, diethyl ether, acetone.
Solubility:Easily soluble in cold water, hot water. Soluble in methanol, diethyl ether, acetone.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
57 Bommasandra Conditions of Instability: Incompatible materials, heat, sources of ignition.
Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:Ethanol rapidly absorbs moisture from the air. Can react vigorously with oxiders. The following oxidants have been demonstrated to undergo vigorous/explosive reaction with ethanol: barium perchlorate, bromine pentafluoride, calcium hypochlorite, chloryl perchlorate, chromium trioxide, chromyl chloride, dioxygendifluoride, disulfuryldifluoride, fluorine nitrate, hydrogen peroxide, iodine heptafluoride, nitric acid nitrosyl perchlorate, perchloric acid permanganic acid, peroxodisulfuric acid, potassium dioxide, potassium perchlorate, potassium permanganate, ruthenium(VIII) oxide, silver perchlorate, silver peroxide, uranium hexafluoride, uranyl perchlorate. Ethanol reacts violently/expodes with the following compounds: acetyl bromide (evolves hydrogen bromide) acetyl chloride, aluminum, sesquibromide ethylate, ammonium hydroxide & silver oxide, chlorate, chromic anhydride,
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 3450 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 39000 mg/m3 4 hours [Mouse].
Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Classified PROVEN for human.
DEVELOPMENTAL TOXICITY: Classified Development toxin [PROVEN]. Classified Reproductive system/toxin/female,Reproductive system/toxin/male [POSSIBLE]. Causes damage to the following organs: blood, the reproductive system, liver, upper respiratory tract, skin, central nervous system (CNS).
Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of inhalation. Slightly hazardous in case of skin contact (permeator), of ingestion.
Special Remarks on Toxicity to Animals:Lowest Published Dose/Conc: LDL[Human] - Route: Oral; Dose: 1400 mg/kg LDL[Human child] - Route: Oral; Dose: 2000 mg/kg LDL[Rabbit] - Route: Skin; Dose: 20000 mg/kg
Special Remarks on Chronic Effects on Humans:May affect genetic material (mutagenic) Causes adverse reproductive effects and birth defects (teratogenic) , based on moderate to heavy consumption. May cause cancer based on animal data. Human: passes through the placenta, excreted in maternal milk.
Special Remarks on other Toxic Effects on Humans:Acute potential health effects: Skin: causes skin irritation Eyes: causes eye irritation Ingestion: May cause gastrointestinal tract irritation with nausea, vomiting, diarrhea, and alterations in gastric secretions. May affect behavior/central nervous system(central nervous system depression - amnesia, headache, muscular incoordination, excitation, mild euphoria,
58 Bommasandra slurred speech, drowsiness, staggaring gait, fatigue, changes in mood/personality, excessive talking, dizziness, ataxia, somnolence, coma/ narcosis, hallucinations, distorted perceptions, general anesthetic), peripherial nervous system (spastic paralysis)vision
(diplopia). Moderately toxic and narcotic in high concentrations. May also affect metabolism, blood, liver, respiration (dyspnea), and endocrine system. May affect respiratory tract, cardiovascular(cardiac arrhythmias, hypotension), and urinary systems.
Inhalation: May cause irritation of the respiratory tract and affect behavior/central nervous system with symptoms similar to ingestion. Chronic Potential Health Effects: Skin: Prolonged or repeated skin contact may casue dermatitis, an allergic reaction. Ingestion: Prolonged or repeated ingestion will have similiar effects as acute ingestion. It may also affect the brain.
Section 12: Ecological Information
Ecotoxicity: Ecotoxicity in water (LC50): 14000 mg/l 96 hours [Rainbow trout]. 11200 mg/l 24 hours [fingerling trout].
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Ethanol UNNA: 1170 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Other Regulations:
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the
European Inventory of Existing Commercial Chemical Substances.
Other Classifications:
59 Bommasandra R11- Highly flammable. S7- Keep container tightly closed. S16- Keep away from sources of ignition - No smoking.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
Section 16: Other Information
The information above is believed to be accurate and represents the best information currently available to us.
60 Bommasandra
PRODUCT: ACETONE
Section 1: Chemical Product and Company Identification
Product Name: Acetone
Synonym: 2-propanone; Dimethyl Ketone;
Dimethylformaldehyde; Pyroacetic Acid
Chemical Name: Acetone
Chemical Formula: C3-H6-O
Acetone 67-64-1 100
Section 3: Hazards Identification
Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female,
Reproductive system/toxin/male [SUSPECTED]. The substance is toxic to central nervous system (CNS). The substance may be toxic to kidneys, the reproductive system, liver, skin. Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.
Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear.
61 Bommasandra Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to- mouth resuscitation. Seek medical attention.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: 465°C (869°F)
Flash Points: CLOSED CUP: -20°C (-4°F). OPEN CUP: -9°C (15.8°F) (Cleveland).
Flammable Limits: LOWER: 2.6% UPPER: 12.8%
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat.
Special Remarks on Fire Hazards: Vapor may travel considerable distance to source of ignition and flash back.
Section 6: Accidental Release Measures
Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.
Section 7: Handling and Storage
Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducing agents, acids, alkalis.
Storage:Store in a segregated and approved area (flammables area) . Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Keep away from direct sunlight and heat and avoid all possible sources of ignition (spark or flame).
Section 8: Exposure Controls/Personal Protection
62 Bommasandra Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.
Exposure Limits: TWA: 500 STEL: 750 (ppm) from ACGIH (TLV) [United States] TWA: 750 STEL: 1000 (ppm) from OSHA (PEL) [United States] TWA: 500 STEL: 1000 [Austalia] TWA: 1185 STEL: 2375 (mg/m3) [Australia] TWA: 750 STEL: 1500 (ppm) [United
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Odor: Fruity. Mint-like. Fragrant. Ethereal
Taste: Pungent, Sweetish
Molecular Weight: 58.08 g/mole
Color: Colorless. Clear pH (1% soln/water): Not available.
Boiling Point: 56.2°C (133.2°F)
Melting Point: -95.35 (-139.6°F)
Critical Temperature: 235°C (455°F)
Specific Gravity: 0.79 (Water = 1)
Vapor Pressure: 24 kPa (@ 20°C)
Vapor Density: 2 (Air = 1)
Volatility: Not available.
Odor Threshold: 62 ppm
Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.2
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water.
Solubility: Easily soluble in cold water, hot water.
Section 10: Stability and Reactivity Data
63 Bommasandra Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Excess heat, ignition sources, exposure to moisture, air, or water, incompatible materials.
Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, acids, alkalis.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation.
Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 3000 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 44000 mg/m3 4 hours [Mouse].
Chronic Effects on Humans: CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [SUSPECTED]. Causes damage to the following organs: central nervous system (CNS). May cause damage to the following organs: kidneys, the reproductive system, liver, skin.
Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause skin irritation. May be harmful if absorbed through the skin. Eyes: Causes eye irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Inhalation:
Inhalation at high concentrations affects the sense organs, brain and causes respiratory tract irritation. It also may affect the
Central Nervous System (behavior) characterized by dizzness, drowsiness, confusion, headache, muscle weakeness, and possibly motor incoordination, speech abnormalities, narcotic effects and coma. Inhalation may also affect the gastrointestinal tract (nausea, vomiting). Ingestion: May cause irritation of the digestive (gastrointestinal) tract (nausea, vomiting). It may also affect the Central Nevous System (behavior), characterized by depression, fatigue, excitement, stupor, coma, headache, altered sleep time, ataxia, tremors as well at the blood, liver, and urinary system (kidney, bladder, ureter) and endocrine system. May also have musculoskeletal effects. Chronic Potential Health Effects: Skin: May cause dermatitis.
64 Bommasandra Section 12: Ecological Information
Ecotoxicity:Ecotoxicity in water (LC50): 5540 mg/l 96 hours [Trout]. 8300 mg/l 96 hours [Bluegill]. 7500 mg/l 96 hours [Fatthead Minnow]. 0.1 ppm any hours [Water flea].
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Section 13: Disposal Considerations
Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Acetone UNNA: 1090 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):
CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects
(TOXIC).DSCL (EEC):
R11- Highly flammable. R36- Irritating to eyes. S9- Keep container in a well-ventilated place. S16- Keep away from sources of ignition - No smoking. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: h
65 Bommasandra National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles.
Section 16: Other Information
The information above is believed to be accurate and represents the best information currently available to us.
66 Bommasandra
PRODUCT: PHOSPHORIC ACID, 85+% SOLUTION IN WATER
Section 1 - Chemical Product and Company Identification
MSDS Name: Phosphoric acid, 85+% solution in water Synonyms:Orthophosphoric acid. Section 2 - Composition, Information on Ingredients
CAS# Chemical Name Percent EINECS/ELINCS 7664-38-2 Phosphoric acid 85 231-633-2 7732-18-5 Water <15 231-791-2
Section 3 - Hazards Identification EMERGENCY OVERVIEW
Appearance: APHA: 10 max liquid. Danger! Causes burns by all exposure routes. Hygroscopic (absorbs moisture from the air). Target Organs: Respiratory system, gastrointestinal system, eyes, skin. Potential Health Effects Eye: May cause irreversible eye injury. Contact with liquid is corrosive to the eyes and causes severe burns. Skin: Contact with liquid is corrosive and causes severe burns and ulceration. Ingestion: Causes gastrointestinal tract burns. Causes severe pain, nausea, vomiting, diarrhea, and shock. May cause hemorrhaging of the digestive tract. May cause corrosion and permanent tissue destruction of the esophagus and digestive tract. Inhalation: Irritation may lead to chemical pneumonitis and pulmonary edema. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. Causes chemical burns to the respiratory tract. Chronic: Prolonged inhalation may cause respiratory tract inflammation and lung damage. Prolonged or repeated skin contact may cause dermatitis. Prolonged or repeated eye contact may cause conjunctivitis.
Section 4 - First Aid Measures Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do not induce vomiting. Get medical aid immediately. Call a poison control center. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Notes to Physician: Treat symptomatically and supportively. Section 5 - Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Substance is noncombustible. Extinguishing Media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire.
67 Bommasandra Flash Point: Not applicable. Autoignition Temperature: Not applicable. Explosion Limits, Lower:Not available. Upper: Not available. NFPA Rating: (estimated) Health: 3; Flammability: 0; Instability: 1 Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Provide ventilation. Do not let this chemical enter the environment. Section 7 - Handling and Storage Handling: Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood. Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Do not store in metal containers. Section 8 - Exposure Controls, Personal Protection Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood. Exposure Limits Chemical Name ACGIH NIOSH OSHA - Final PELs 1 mg/m3 TWA; 3 mg/m3 1 mg/m3 TWA 1000 mg/m3 Phosphoric acid 1 mg/m3 TWA STEL IDLH Water none listed none listed none listed
OSHA Vacated PELs: Phosphoric acid: 1 mg/m3 TWA Water: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - Physical and Chemical Properties Physical State: Liquid Appearance: APHA: 10 max Odor: odorless pH: Not available. Vapor Pressure: Not available. Vapor Density: 3.4 (air=1) Evaporation Rate:Not available. Viscosity: Not available. Boiling Point: 158 deg C @ 760 mmHg Freezing/Melting Point:21 deg C Decomposition Temperature:300 deg C Solubility: Miscible. Specific Gravity/Density:1.680 Molecular Formula:H3O4P Molecular Weight:98 Section 10 - Stability and Reactivity Chemical Stability: Hygroscopic: absorbs moisture or water from the air. Conditions to Avoid: Incompatible materials, metals, excess heat, exposure to moist air or water. Incompatibilities with Other Materials: Metals, bases, alcohols, amines, halogenated agents, organic peroxides, amides, azo, diazo, and hydrazines (e.g. dimethyl hydrazine, hydrazine, methyl hydrazine), carbamates (e.g. carbanolate, carbofuran), esters (e.g. butyl acetate, ethyl acetate, propyl formate), fluorides (inorganic, e.g. ammonium fluoride, calcium fluoride, cesium fluoride), phenols and cresols, organophosphates, phosphothioates
68 Bommasandra (e.g. methylparathion, parathion, phorate, thionazin), epoxides (e.g. butyl glycidyl ether), combustible and flammable materials (e.g. alkyl resins, asphalt, gasoline, grease, methyl acetone, polystyrene, polyurethane), explosives (e.g. ammonium nitrate, hydrazoic acid, sodium azide), nitromethane, sodium tetrahydroborate, mercaptans, aldehydes, ketones, glycols, cyanides, sulfides, caustics. Hazardous Decomposition Products: Phosphine, oxides of phosphorus, hydrogen gas. Hazardous Polymerization: May occur. Section 11 - Toxicological Information RTECS#: CAS# 7664-38-2: TB6300000 CAS# 7732-18-5: ZC0110000 LD50/LC50: CAS# 7664-38-2: Draize test, rabbit, eye: 119 mg Severe; Draize test, rabbit, skin: 595 mg/24H Severe; Inhalation, mouse: LC50 = 25.5 mg/m3; Inhalation, rat: LC50 = >850 mg/m3/1H; Inhalation, rat: LC50 = 25.5 mg/m3; Oral, mouse: LD50 = 1.25 gm/kg; Oral, rat: LD50 = 1530 mg/kg; Oral, rat: LD50 = 1.25 gm/kg; Skin, rabbit: LD50 = 2740 mg/kg; .CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg; Carcinogenicity: CAS# 7664-38-2: Not listed by ACGIH, IARC, NTP, or CA Prop 65. CAS# 7732-18-5: Not listed by ACGIH, IARC, NTP, or CA Prop 65. Epidemiology: No information found Teratogenicity: No information found Reproductive Effects: No information found Mutagenicity: No information found Neurotoxicity: No information found Section 12 - Ecological Information Ecotoxicity: Fish: Mosquito Fish: LC50 = 138 mg/L; 96 Hr; Unspecified No data available. Environmental: The acidity of phosphoric acid may be reduced readily by natural water hardness minerals, but the phosphate may persist indefinitely. During transport through the soil, phosphoric acid will dissolve some of the soil material, in particular, carbonate-based materials. The acid will be neutralized to some degree with adsorption of the proton and phosphate ions also possible. However, significant amounts of acid will remain for transport down toward the groundwater table. Physical: No information available. Other: Dangerous to aquatic life in high concentrations. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. Section 14 - Transport Information US DOT Canada TDG Shipping Name: PHOSPHORIC ACID SOLUTION PHOSPHORIC ACID SOLUTION Hazard Class: 8 8 UN Number: UN1805 UN1805 Packing Group: III III
Section 15 - Regulatory Information US FEDERAL
69 Bommasandra TSCA CAS# 7664-38-2 is listed on the TSCA inventory. CAS# 7732-18-5 is listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs CAS# 7664-38-2: 5000 lb final RQ; 2270 kg final RQ SARA Section 302 Extremely Hazardous Substances None of the chemicals in this product have a TPQ. SARA Codes CAS # 7664-38-2: immediate. Section 313 No chemicals are reportable under Section 313. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: CAS# 7664-38-2 is listed as a Hazardous Substance under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# 7664-38-2 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts. CAS# 7732-18-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ. WGK (Water Danger/Protection) CAS# 7664-38-2: 1 CAS# 7732-18-5: No information available. Section 16 - Additional Information The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.
70 Bommasandra
PRODUCT: POTASSIUM PHOSPHATE, MONOBASIC
Section 1 - Chemical Product and Company Identification
MSDS Name: Potassium phosphate, monobasic Synonyms: Dihydrogen potassium phosphate; Monopotassium phosphate; Phosphoric acid, monopotassium salt; Potassium dihydrogen phosphate; Potassium dihydrogen orthophosphate. Section 2 - Composition, Information on Ingredients
CAS# Chemical Name Percent EINECS/ELINCS 7778-77-0 Potassium phosphate, monobasic >99 231-913-4
Section 3 - Hazards Identification EMERGENCY OVERVIEW :Appearance: colorless to white crystals. Caution! May cause eye, skin, and respiratory tract irritation. Hygroscopic (absorbs moisture from the air). Target Organs: None. Potential Health Effects Eye: Dust may cause mechanical irritation. Skin: May cause skin irritation. Low hazard for usual industrial handling. Ingestion: May cause irritation of the digestive tract. Low hazard for usual industrial handling. Inhalation: May cause respiratory tract irritation. Chronic: Ingestion of large doses may cause nausea, vomiting, diarrhea. Chronic exposure to this product may cause calcium phosphate deposition in the kidneys. Section 4 - First Aid Measures Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid. Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. Notes to Physician: Persons with impaired kidney function may be more susceptible to the effects of this substance. Treat symptomatically and supportively. Section 5 - Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Flash Point: Not applicable. Autoignition Temperature: Not applicable. Explosion Limits, Lower:Not available. Upper: Not available. NFPA Rating: (estimated) Health: 1; Flammability: 0; Instability: 0 Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8.
71 Bommasandra Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - Handling and Storage Handling: Wash thoroughly after handling. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust, mist, or vapor. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well- ventilated area away from incompatible substances. Store protected from moisture. Section 8 - Exposure Controls, Personal Protection
Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits Chemical Name ACGIH NIOSH OSHA - Final PELs Potassium phosphate, none listed none listed none listed monobasic
OSHA Vacated PELs: Potassium phosphate, monobasic: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - Physical and Chemical Properties Physical State: Crystals Appearance: fine - colorless to white Odor: Odorless pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate:Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point:252.6 deg C Decomposition Temperature:> 253 deg C Solubility: Soluble. Specific Gravity/Density:2.338 g/cm3 Molecular Formula:KH2PO4 Molecular Weight:136.08 Section 10 - Stability and Reactivity Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Dust generation, moisture. Incompatibilities with Other Materials: No significant incompatibilities identified with common materials and contaminants.. Hazardous Decomposition Products: Oxides of phosphorus, irritating and toxic fumes and gases. Hazardous Polymerization: Will not occur. Section 11 - Toxicological Information RTECS#: CAS# 7778-77-0: TC6615500 LD50/LC50: CAS# 7778-77-0: Skin, rabbit: LD50 = >4640 mg/kg;
72 Bommasandra Carcinogenicity: CAS# 7778-77-0: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No information found Teratogenicity: No information found Reproductive Effects: No information found Mutagenicity: No information found Neurotoxicity: No information found Section 12 - Ecological Information Ecotoxicity: No data available. No information available. Environmental: No information available. Physical: No information available. Other: When too many nutrients such as phosphorus are in the water, algae grows maniacally. Algae blooms are followed by a die-off, and as material decays, it consumes oxygen like a forest fire. No fish, plants or insects can live in oxygen-free zones. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed. Section 14 - Transport Information US DOT Canada TDG Shipping Name: Not regulated as a hazardous material No information available. Hazard Class: UN Number: Packing Group:
Section 15 - Regulatory Information US FEDERAL TSCA CAS# 7778-77-0 is listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs None of the chemicals in this material have an RQ. SARA Section 302 Extremely Hazardous Substances None of the chemicals in this product have a TPQ. SARA Codes CAS # 7778-77-0: immediate. Section 313 No chemicals are reportable under Section 313. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA.
73 Bommasandra None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. Section 16 - Additional Information
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.
74 Bommasandra
PRODUCTD:DIPHENYLCHLOROPHOSPHATE
Section 1 - Chemical Product and Company Identification MSDS Name:Diphenylchlorophosphate Synonyms:Diphenylphosphorochloridate. Section 2 - Composition, Information on Ingredients
CAS# Chemical Name Percent EINECS/ELINCS 2524-64-3 Diphenylchlorophosphate 98 219-759-6
Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: colorless to light yellow clear liquid. Danger! Causes burns by all exposure routes. Contact with water liberates toxic gas. Target Organs: Respiratory system, gastrointestinal system, eyes, skin. Potential Health Effects Eye: Causes eye burns. Skin: Causes skin burns. May be harmful if absorbed through the skin. Ingestion: Causes gastrointestinal tract burns. May be harmful if swallowed. Inhalation: May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Causes chemical burns to the respiratory tract. Chronic: No information found. Section 4 - First Aid Measures Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do not induce vomiting. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Notes to Physician: Treat symptomatically and supportively. Section 5 - Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water reactive. Material will react with water and may release a flammable and/or toxic gas. Extinguishing Media: Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER! Flash Point:> 112 deg C (> 233.60 deg F) Autoignition Temperature: Not available. Explosion Limits, Lower:Not available. Upper: Not available. NFPA Rating: (estimated) Health: 3; Flammability: 1; Instability: 2; Special Hazard: -W- Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Provide ventilation. Do not expose spill to water. Do not let this chemical enter the environment.
75 Bommasandra Section 7 - Handling and Storage Handling: Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use and store under nitrogen. Do not allow contact with water. Use only in a chemical fume hood. Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Store under nitrogen. Section 8 - Exposure Controls, Personal Protection Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood. Exposure Limits Chemical Name ACGIH NIOSH OSHA - Final PELs Diphenylchlorophosphate none listed none listed none listed
OSHA Vacated PELs:Diphenylchlorophosphate: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - Physical and Chemical Properties Physical State: Clear liquid Appearance: colorless to light yellow Odor: None reported. pH: Not available. Vapor Pressure: 10 mm Hg @ 190 deg C Vapor Density: 9.26 Evaporation Rate:Not available. Viscosity: 14 cP 25 deg C Boiling Point: 314 - 316 deg C @ 272.00mm Hg Freezing/Melting Point:Not available. Decomposition Temperature:Not available. Solubility: may decompose Specific Gravity/Density:1.290g/cm3 Molecular Formula:C12H10ClO3P Molecular Weight:268.63 Section 10 - Stability and Reactivity Chemical Stability: Reacts with water to form toxic fumes. Conditions to Avoid: Incompatible materials, exposure to moist air or water. Incompatibilities with Other Materials: Strong bases, strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, oxides of phosphorus, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - Toxicological Information LD50/LC50: Not available. Carcinogenicity: CAS# 2524-64-3: Not listed by ACGIH, IARC, NTP, or CA Prop 65. Epidemiology: No information found Teratogenicity: No information found Reproductive Effects: No information found Mutagenicity: No information found Neurotoxicity: No information found Other Studies: Section 12 - Ecological Information Ecotoxicity: No data available. No information available.
76 Bommasandra Environmental: No information available. Physical: No information available. Other: Do not empty into drains. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed. Section 14 - Transport Information US DOT Canada TDG CORROSIVE LIQUID, ACIDIC, ORGANIC, CORROSIVE LIQUID, ACIDIC, ORGANIC, Shipping Name: N.O.S N.O.S Hazard Class: 8 8 UN Number: UN3265 UN3265 Packing Group: II II
Section 15 - Regulatory Information US FEDERAL TSCA CAS# 2524-64-3 is listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs None of the chemicals in this material have an RQ. SARA Section 302 Extremely Hazardous Substances None of the chemicals in this product have a TPQ. Section 313 No chemicals are reportable under Section 313. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# 2524-64-3 is not present on state lists from CA, PA, MN, MA, FL, or NJ. Section 16 - Additional Information
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.
77 Bommasandra PRODUCT: Pd/c
1. Product Identification MSDS Name: Palladium on Activated Carbon (10% Pd) synonyms: None. 2. Composition CAS# Chemical Name Percent EINECS/ELINCS Activated Carbon Balance unlisted 7440-05-3 Palladium 10% 231-115-6 Hazard Symbols: F Risk Phrases: 7 3. Hazards Identification EMERGENCY OVERVIEW Appearance: black. Caution! Flammable solid. May cause eye and skin irritation. May cause respiratory and digestive tract irritation. Target Organs: None. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. Inhalation: May cause respiratory tract irritation. Chronic: None 4. First Aid Measures Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. Notes to Physician: Treat symptomatically and supportively. 5. Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Use agent most appropriate to extinguish fire. 6. Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Remove all sources of ignition. Use a spark-proof tool. Provide
78 Bommasandra ventilation. 7. Handling and Storage Handling: Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood. Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. 8. Exposure Controls, Personal Protection Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Exposure Limits Chemical Name ACGIH NIOSH OSHA - Final PELs Activated Carbon none listed none listed none listed https://fscimage.fishersci.com/msds/06142.htm (2 of 6) [2/17/2002 8:57:00 AM] Palladium none listed none listed none listed OSHA Vacated PELs: Activated Carbon: No OSHA Vacated PELs are listed for this chemical. Palladium: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear a chemical apron. Wear appropriate clothing to prevent skin exposure. Respirators: Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149. 9. Physical and Chemical Properties Physical State: Solid Appearance: black Odor: Odorless pH: Not available. Vapor Pressure: Negligible Vapor Density: Not available. Evaporation Rate:Negligible. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point:Not available. Autoignition Temperature: > 100 deg C (> 212.00 deg F) Flash Point: Not available. Decomposition Temperature:> 100 deg C NFPA Rating: Not published. Explosion Limits, Lower:N/A Upper: N/A Solubility: insoluble Specific Gravity/Density:12.02 g/cm3 Molecular Formula:Pd Molecular Weight:106.42 10. Stability and Reactivity
79 Bommasandra Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Exposure to air, combustible materials, temperatures above 100°C. Incompatibilities with Other Materials: Strong acids, halogens, oxidizing agents, alcohols, sulfur. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur. 11. Toxicological Information LD50/LC50: Not available. Not available. Carcinogenicity: CAS# : Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. CAS# 7440-05-3: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Epidemiology: No information available. Teratogenicity: No information available. Reproductive Effects: No information available. Neurotoxicity: No information available. Mutagenicity: No information available. Other Studies: No data available. 12. Ecological Information No information available. 13. Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed. 14. Transport Information FLAMMABLESOLIDS, ORGANIC,N.O.S.(PALLADIUMONACTIVATEDCARBON)FLAMMABLE SOLID Hazard Class: 4.1 4.1 UN Number: UN1325 UN1325 https://fscimage.fishersci.com/msds/06142.htm (4 of 6) [2/17/2002 8:57:00 AM] Packing Group: II II 15. Regulatory Information TSCA CAS# is not listed on the TSCA inventory. It is for research and development use only. CAS# 7440-05-3 is listed on the TSCA inventory. Health & Safety Reporting List-None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules-None of the chemicals in this product are under a Chemical Test Rule. Section 12b=None of the chemicals are listed under TSCA Section 12b.
80 Bommasandra TSCA Significant New Use Rule-None of the chemicals in this material have a SNUR under TSCA. SARA Section 302 (RQ)-None of the chemicals in this material have an RQ. Section 302 (TPQ)-None of the chemicals in this product have a TPQ. SARA Codes-CAS # 7440-05-3: flammable. Section 313=No chemicals are reportable under Section 313. Clean Air Act:This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# is not present on state lists from CA, PA, MN, MA, FL, or NJ. 16. Other Information The information above is believed to be accurate and represents the best information currently available to us.
81 Bommasandra
PRODUCT: CILASTATIN SODIUM
(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid sodium salt 1. COMPOSITION/INFORMATION ON INGREDIENTS For batch specific information, please see Product Information sheet. 2. PHYSICAL AND CHEMICAL PROPERTIES For batch specific information, please see Product Information sheet. 3. HANDLING AND STORAGE Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid prolonged or repeated exposure. Material should be stored in a tightly sealed container under the storage condition stated on the Product Information sheet and on the vial label. 4. STABILITY AND REACTIVITY Stability: Stable under normal handling conditions. Conditions to avoid: Not applicable for this product Hazardous Combustion/Decomposition of Product: May emit toxic gases such as carbon dioxide, carbon monoxide and nitrogen oxide upon thermal decomposition. 5. HAZARDS IDENTIFICATION RTECS substance category: Drug (D) Exposure may cause irritation to eyes, mucous membranes, upper respiratory tract and skin. Exposure may also cause the following:convulsions or effect on seizure threshold; pleural thickening. 6. TOXICOLOGICAL INFORMATION To the best of our knowledge, the chemical, physical and toxicological properties have not been fully investigated. Only selected Registry of Toxic Effects of Chemical Substances (RTECS) data is presented above. See actual entry in RTECS for complete information. 7. REGULATORY INFORMATION Classification: Caution: Substance not yet fully tested. RTECS No: MJ9650200 Target Organs: Eyes; Respiratory system; Skin; CNS. Toxicity Data: ORL-RAT LD50: >10gm/kg; SCU-RAT LD50: >10gm/kg; IVN-RAT LD50: 5027mg/kg; ORL-MUS LD50: >10gm/kg; SCU-MUS LD50: >10gm/kg; IVN-MUS LD50: 6786mg/kg. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Wear appropriate chemical resistant gloves, safety goggles and other protective clothing to prevent contact with eyes and skin. Laboratory should be equipped with a safety shower and eye wash station. Avoid prolonged or repeated exposure. Do not breathe dust. Do not get in eyes, on skin or on clothing. Wash thoroughly after handling. 9. FIRST-AID MEASURES In cases of SKIN CONTACT: Wash with copious amounts of water for at
82 Bommasandra least 15 minutes. Remove contaminated clothing and shoes and wash before wearing. In case of eye contact, flush with copious amounts of water for at least 15 minutes. In cases of INHALATION: Remove to fresh air and monitor breathing. If breathing becomes difficult, give oxygen. If breathing stops, give artificial respiration. In cases of INGESTION: If swallowed, rinse mouth out with water, contact local poison centre and call a physician. 10. FIRE-FIGHTING MEASURES Extinguishing Media: Material is non-combustible. Use extinguishing media appropriate to surrounding fire conditions. Unusual Fire and Explosive Hazards: May emit toxic gases upon thermal decomposition. Special Fire-Fighting Procedures: Wear protective clothing to prevent contact with skin and eyes. 11. ACCIDENTAL RELEASE MEASURES Wear appropriate protective clothing. Cover spillage with suitable absorbent material. Using non-spark tools, sweep up material and place in an appropriate container. Decontaminate spill site with with 10% caustic solution and ventilate area until after disposal is complete. Hold all material for appropriate disposal as described under DISPOSAL CONDITIONS. 12. ECOLOGICAL INFORMATION Data not yet available - treat as potentially toxic if released into the environment. 13. DISPOSAL CONDITIONS As specific country, federal, state and local environmental regulations are varied and change frequently, we recommend that you contact your local department for Health Services for information on the correct disposal of this product. 14. TRANSPORT INFORMATION U.N.Number: Proper Shipping Name: IATA Class: IATA Packing Group: 15. OTHER INFORMATION Due to the nature of this material. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorised facilities. The above information is believed to be correct but does not purport to be all inclusive and should be used as a guide only for experienced personnel. Always consult your safety advisor and follow appropriate local and national safety legislature. The absence of warning must not, under any circumstance, be taken to mean that no hazard exists.
83 Bommasandra
PRODUCT: ISOPROPYL ALCOHOL Section 1: Chemical Product and Company Identification Product Name: Isopropyl alcohol CAS#: 67-63-0 Synonym: 2-Propanol Chemical Name: isopropanol Chemical Formula: C3-H8-O Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Isopropyl alcohol 67-63-0 100 Toxicological Data on Ingredients: Isopropyl alcohol: ORAL (LD50): Acute: 5045 mg/kg [Rat]. 3600 mg/kg [Mouse]. 6410 mg/kg [Rabbit]. DERMAL (LD50): Acute: 12800 mg/kg [Rabbit]. Section 3: Hazards Identification Potential Acute Health Effects:Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant,sensitizer, permeator).Potential Chronic Health Effects: Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.)by ACGIH, 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE]. The substance may be toxic to kidneys, liver, skin, central nervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage. Section 4: First Aid Measures Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention. Skin Contact:Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin Contact: Not available. Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear. Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to- mouth resuscitation. Seek medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: Flammable. Auto-Ignition Temperature: 399°C (750.2°F) Flash Points: CLOSED CUP: 11.667°C (53°F) - 12.778 deg. C (55 deg. F) (TAG) Flammable Limits: LOWER: 2% UPPER: 12.7% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat. Flammable in presence of oxidizing materials. Nonflammable in presence of shocks. Explosion Hazards in Presence of Various Substances:
84 Bommasandra Risks of explosion of the product in presence of mechanical impact: Not available. Explosive in presence of open flames and sparks, of heat. Fire Fighting Media and Instructions: Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog. Section 6: Accidental Release Measures Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Section 7: Handling and Storage Precautions: Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, acids. Storage: Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Section 8: Exposure Controls/Personal Protection Exposure Limits: TWA: 983 STEL: 1230 (mg/m3) [Australia] TWA: 200 STEL: 400 (ppm) from ACGIH (TLV) [United States] [1999] TWA: 980 STEL: 1225 (mg/m3) from NIOSH TWA: 400 STEL: 500 (ppm) from NIOSH TWA: 400 STEL: 500 (ppm) [United Kingdom (UK)] TWA: 999 STEL: 1259 (mg/m3) [United Kingdom (UK)] TWA: 400 STEL: 500 (ppm) from OSHA (PEL) [United States] TWA: 980 STEL: 1225 (mg/m3) from OSHA (PEL) [United States]Consult local authorities for acceptable exposure limits. Section 9: Physical and Chemical Properties Physical state and appearance: Liquid. Odor: Pleasant. Odor resembling that of a mixture of ethanol and acetone. Taste: Bitter. (Slight.) Molecular Weight: 60.1 g/mole Color: Colorless. pH (1% soln/water): Not available. Boiling Point: 82.5°C (180.5°F) Melting Point: -88.5°C (-127.3°F) Critical Temperature: 235°C (455°F) Specific Gravity: 0.78505 (Water = 1) Vapor Pressure: 4.4 kPa (@ 20°C) Vapor Density: 2.07 (Air = 1) Volatility: Not available. Odor Threshold: 22 ppm (Sittig, 1991) 700 ppm for unadapted panelists (Verschuren, 1983).
85 Bommasandra Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Heat, Ignition sources, incompatible materials Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis. Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Reacts violently with hydrogen + palladium combination, nitroform, oleum, COCl2, aluminum triisopropoxide, oxidants Incompatible with acetaldehyde, chlorine, ethylene oxide, isocyanates, acids, alkaline earth, alkali metals, caustics, amines,crotonaldehyde, phosgene, ammonia. Isopropyl alcohol reacts with metallic aluminum at high temperatures. Isopropyl alcoholattacks some plastics, rubber, and coatings. Vigorous reaction with sodium dichromate + sulfuric acid. Special Remarks on Corrosivity: May attack some forms of plastic, rubber and coating Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 3600 mg/kg [Mouse]. Acute dermal toxicity (LD50): 12800 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50):16000 8 hours [Rat]. Chronic Effects on Humans: CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE]. May cause damage to the following organs: kidneys, liver, skin, central nervous system (CNS). Other Toxic Effects on Humans: Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, sensitizer, permeator). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: May cause mild skin irritation, and sensitization. Eyes: Can cause eye irritation. Inhalation: Breathing in small amounts of this material during normal handling is not likely to cause harmful effects. However,breathing large amounts may be harmful and may affect the respiratory system and mucous membranes (irritation), behavior and brain (Central nervous system depression - headache, dizziness, drowsiness, stupor, incoordination, unconciousness,coma and possible death), peripheral nerve and senstation, blood, urinary system, and liver. Ingestion: Swallowing small amouts during normal handling is not likely to cause harmful effects. Swallowing large amounts may be harmful. Swallowing large amounts may cause gastrointestinal tract irritation with nausea, vomiting and diarrhea, abdominal pain. It also may affect the urinary system, cardiovascular system, sense organs, behavior or central nervous system (somnolence, generally depressed activity, irritability, headache, dizziness, drowsiness), liver, and respiratory system (breathing difficulty). Chronic Potential Health Effects: May cause defatting of the skin and dermatitis and allergic reaction. May cause adverse reproductive effects based on animal data (studies). Section 12: Ecological Information Ecotoxicity: Ecotoxicity in water (LC50): 100000 mg/l 96 hours [Fathead Minnow]. 64000 mg/l 96 hours [Fathead Minnow]. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available.
86 Bommasandra Section 13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information DOT Classification: CLASS 3: Flammable liquid. Identification: : Isopropyl Alcohol UNNA: 1219 PG: II Special Provisions for Transport: Not available. Section 15: Other Regulatory Information Federal and State Regulations: Connecticut hazardous material survey.: Isopropyl alcohol Illinois toxic substances disclosure to employee act: Isopropyl alcohol Rhode Island RTK hazardous substances: Isopropyl alcohol Pennsylvania RTK: Isopropyl alcohol Florida: Isopropyl alcohol Minnesota: Isopropyl alcohol Massachusetts RTK: Isopropyl alcohol New Jersey: Isopropyl alcohol New Jersey spill list: Isopropyl alcohol Director's list of Hazardous Substances: Isopropyl alcohol Tennesee: Isopropyl alcohol TSCA 8(b) inventory: Isopropyl alcohol TSCA 4(a) final testing order: Isopropyl alcohol TSCA 8(a) IUR: Isopropyl alcohol TSCA 8(d) H and S data reporting: Isopropyl alcohol: Effective date: 12/15/86 Sunset Date: 12/15/96 TSCA 12(b) one time export: Isopropyl alcohol SARA 313 toxic chemical notification and release reporting: Isopropyl alcohol Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: eyes. S7- Keep container tightly closed. S16- Keep away from sources of ignition - No smoking. S24/25- Avoid contact with skin and eyes. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 3 Reactivity: 0 Personal Protection: h National Fire Protection Association (U.S.A.): Health: 1 Flammability: 3 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles. Section 16: Other Information The information above is believed to be accurate and represents the best information currently available to us.
87 Bommasandra
PRODUCT: FORMIC ACID 1. Product Identification Synonyms: Methanoic Acid; Hydrogen Carboxylic Acid; Aminic Acid. CAS No.: 64-18-6 Molecular Weight: 46.02 Chemical Formula: CH2O2 2. Composition/Information on Ingredients CAS# Chemical Name Percent EINECS/ELINCS 64-18-6 Formic Acid 85-98 200-579-1 7732-18-5 Water 2-15 231-791-2 Hazard Symbols: C Risk Phrases: 34 3. Hazards Identification EMERGENCY OVERVIEW Appearance: clear, colorless. Flash Point: 69 deg C. Corrosive. Danger! May be harmful if swallowed. Causes eye and skin burns. May cause liver and kidney damage. Combustible liquid and vapor. May cause severe respiratory tract irritation with possible burns. May cause severe digestive tract irritation with possible burns. Possible sensitizer. May cause central nervous system depression. Lachrymator (substance which increases the flow of tears). Target Organs: Kidneys, central nervous system, liver, respiratory system, eyes, skin. Potential Health Effects Eye: Contact with liquid is corrosive to the eyes and causes severe burns. Lachrymator (substance which increases the flow of tears). May cause corneal edema, ulceration, and scarring. Skin: May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Contact with liquid is corrosive and causes severe burns and ulceration. Absorbed through the skin. May cause erythema (redness) and blistering. Ingestion: Causes severe digestive tract burns with abdominal pain, vomiting, and possible death. May be harmful if swallowed. May cause central nervous system depression. Ingestion may produce corrosive ulceration and bleeding and necrosis of the gastrointestinal tract accompanied by shock and circulatory collapse. Inhalation: May cause asthmatic attacks due to allergic sensitization of the respiratory tract. Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. Vapors may cause dizziness, nausea, itching, burning, and swelling of the eyes. Chronic: Prolonged or repeated skin contact may cause dermatitis. May cause liver and kidney damage. Effects may be delayed. Laboratory experiments have resulted in mutagenic effects. 4. First Aid Measures Eyes: Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes). Skin: Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: Hemodialysis should be considered in severe intoxication. Persons with chronic respiratory, skin, kidney, or liver diseases or eye disorders may be at increased risk from exposure to this product.
88 Bommasandra Antidote: Folic acid may be of benefit by hastening the metabolism of formic acid to carbon dioxide. 5. Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Vapors may be heavier than air. They canspread along the ground and collect in low or confined areas. May polymerize explosively when involved in a fire. Contact with metals may evolve flammable hydrogen gas. Extinguishing Media: Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out. 6. Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Large spills may be neutralized with dilute alkaline solutions of soda ash, or lime. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Absorb spill using anabsorbent, non- combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as saw dust. Use a spark-proof tool. Provide ventilation. Do not get water inside containers. 7. Handling and Storage Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Contents may develop pressure upon prolonged storage. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Do not store in metal containers. Do not store near alkaline substances. Vent periodically. 8. Exposure Controls/Personal Protection Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Exposure Limits Chemical Name ACGIH NIOSH OSHA - Final PELs Formic Acid 5 ppm TWA; 10 ppm 5 ppm TWA; 9 mg/m3 5 ppm TWA; 9 mg/m3 STEL TWA 30 ppm IDLH TWA OSHA Vacated PELs: Formic Acid: 5 ppm TWA; 9 mg/m3 TWA Water: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear neoprene gloves, apron, and/or clothing. Wear butyl rubber gloves, apron, and/or clothing. Clothing: Wear neoprene gloves, apron, and/or clothing. Wear butyl rubber gloves, apron, and/or clothing. Respirators: A respiratory protection program that meets OSHA's 29 CFR §1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. 9. Physical and Chemical Properties Physical State: Liquid Appearance: clear, colorless Odor: pungent odor - benzaldehyde-like pH: Strong acid Vapor Pressure: 44.8 mm Hg @ 20 deg C
89 Bommasandra Vapor Density: 1.59 Evaporation Rate:2.1 Viscosity: 1.607mPa @ 25 deg C Boiling Point: 100.8 deg C Freezing/Melting Point:8 deg C Autoignition Temperature: 434 deg C ( 813.20 deg F) Flash Point: 50C (122F) CC Decomposition Temperature:Not available. NFPA Rating: (estimated) Health: 3; Flammability: 2; Reactivity: 0 Explosion Limits, Lower:18.0 vol % Upper: 57.0 vol % Solubility: Miscible. Specific Gravity/Density:1.2267 Molecular Formula:HCOOH Molecular Weight:46.0128 10. Stability and Reactivity Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, metals, excess heat, combustible materials, oxidizers, plastics. Incompatibilities with Other Materials: Strong oxidizing agents, strong bases, finely powdered metals, permanganates, sulfuric acid, hydrogen peroxides, nitromethane, furfuryl alcohol, hydrated thallium nitrate. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported 11. Toxicological Information LD50/LC50: CAS# 64-18-6: Draize test, rabbit, eye: 122 mg Severe; Inhalation, mouse: LC50 = 6200 mg/m3/15M; Inhalation, rat: LC50 = 15 gm/m3/15M; Oral, mouse: LD50 = 700 mg/kg; Oral, rat: LD50 = 1100 mg/kg; 90 Bommasandra Environmental: Formic acid is the strongest unsubstituted carboxylic acid with a pKa of 3.74(3) and will exist almost entirely as the anion at environmental pHs. If released on land, formic acid should leach into some soils where it would probably biodegrade. Physical: Formic acid can be degraded chemically to innocuous substances in most environments. Other: No information available 13. Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. 14. Transport Information US DOT IATA RID/ADR IMO Canada TDG Shipping Name: FORMIC ACID FORMIC ACID Hazard Class: 8 8(9.2) UN Number: UN1779 UN1779 Packing Group: II II 15. Regulatory Information None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: CAS# 64-18-6 is listed as a Hazardous Substance under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. Hazard Symbols: C Risk Phrases: R 34 Causes burns. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where S 23C Do not breathe vapour. WGK (Water Danger/Protection) CAS# 64-18-6: 1 CAS# 7732-18-5: No information available. 16. Other Information The information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material 91 Bommasandra by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. Material Safety Data Sheet Section 1 - Chemical Product and Company Identification MSDS Name: 4R,5R,6S)-4-Nitrobenzyl 3-(diphenoxyphosphoryloxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-az abicyclo[3.2.0]hept-2-ene-2-carboxylate Synonyms: Company Identification: PI Chemicals Ltd. Room 512, Building 1 88 CailunRoad，Zhangjiang Hi-Tech park， Pudong New Area, Shanghai 201203, China Telephone Number: 86-21-58953700 Fax Number: 86-21-58953701 Section 2 - Product Information Catalog Number: PI-10909 CAS Number: 90776-59-3 MDL Number: Not available EC Number: None Purity: 98.0% Section 3 - Physical and Chemical Properties Physical state: Crystaline powder Color: White or off-white Odor: Not available Molecular Formula: C29H27N2O10P Molecular Weight: 594.51 Freezing/Melting Point: Not available Boiling Point: Not available Flash Point: Not available Autoignition Temperature: Not available Refractive Index (nD20): Not available Density: Not available Decomposition Temperature: Not available Solubility: Not available Section 4 - Hazards Identification PI CHEMICALS LTD. www.pipharm.com 2 Eye: Causes eye irritation. Skin: Causes skin irritation. Harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. Toxic if swallowed. Inhalation: May be harmful if inhaled. Causes respiratory tract irritation. Section 5 - First Aid Measures Eye: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lowereyelids. Get medical aid. 92 Bommasandra Skin: Get medical aid. Flush skin with plenty of water and soap for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops and persists. Ingestion: Get medical aid immediately. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Section 6 - Stability and Reactivity Chemical Stability: Stable under normal temperatures and pressures. Materials to avoid: Strong oxidizing agents. Conditions to Avoid: Incompatible materials. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides. Hazardous Polymerization: Will not occur. Section 7 - Handling and Storage Handling: Avoid breathing dust, vapor, mist, or gas. Keep container tightly closed. Avoid contact with skin and eyes. Wash thoroughly after handling. Mechanical exhaust required. Storage: Store in a cool, dry well ventilated place away from sources of heat and incompatible substances. Keep container tightly closed when not in use. Store at 2-8 deg C Section 8 - Personal Protection Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - Fire and Explosion Hazard Data General Information: As in any fire, wear a self-contained breathing apparatus, MSHA/NIOSH PI CHEMICALS LTD. www.pipharm.com 3 (approved or equivalent) and protective clothing to prevent contact with skin and eyes. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 10 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 11 - Toxicological Information 93 Bommasandra RTECS#: CAS#90776-59-3: Not available LD50/LC50: RTECS: Not available. Carcinogenicity: 4R,5R,6S)-4-Nitrobenzyl 3-(diphenoxyphosphoryloxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1- azabicyclo[3.2.0] hept-2-ene-2-carboxylate - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. Section 12 - Environmental information Not available Section 13 - Disposal Consideration Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state and local environmental regulations. Section 14 - Transport Information IATA: This substance is considered to be non-hazardous for transport. IMO: This substance is considered to be non-hazardous for transport. RID/ADR: This substance is considered to be non-hazardous for transport. Section 15 - Regulatory Information European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Xi Indication of Danger: Irritant Risk Phrases: R 22: Harmful if swallowed. Safety Phrases: S 24/25: Avoid contact with skin and eyes. PI CHEMICALS LTD. www.pipharm.com 4 S 26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. WGK (WaterDanger/Protection) CAS#90776-59-3: 3 Canada CAS#90776-59-3: Not available US Federal TSCA CAS# 90776-59-3 is not listed on the TSCA Inventory. It is for research and development use only. Section 16 - Additional Information MSDS Creation Date: March 25, 2006 Update: February 20, 2008 The above information is believed to be accurate and represents the best knowledge available to us currently. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the 94 Bommasandra suitability of the information for their particular purposes. In no way shall PI Chemicals, be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, even if PI Chemicals has been advised of the possibility of such damages. Note: For R&D use only. Material Safety Data Sheet N,N-Diisopropylethylamine MSDS Section 1: Chemical Product and Company Identification Product Name: N,N-Diisopropylethylamine Catalog Codes: SLD1771 CAS#: 7087-68-5 RTECS: Not available. TSCA: TSCA 8(b) inventory: N,N-Diisopropylethylamine CI#: Not available. Synonym: N-Ethyldiisopropylamine; Hunigs's Base Chemical Name: N,N-Diisopropylethylamine Chemical Formula: C8-H19-N Contact Information: Sciencelab.com, Inc. 14025 Smith Rd. Houston, Texas 77396 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight {N,N-}Diisopropylethylamine 7087-68-5 100 Toxicological Data on Ingredients: N,N-Diisopropylethylamine LD50: Not available. LC50: Not available. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (corrosive, permeator), of eye contact (corrosive). Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure is not known to aggravate medical condition. Section 4: First Aid Measures Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention immediately. p. 2 Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get 95 Bommasandra medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Seek medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: Flammable. Auto-Ignition Temperature: Not available. Flash Points: CLOSED CUP: 10°C (50°F). Flammable Limits: Not available. Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: Flammable liquid. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam, water spray or fog. Special Remarks on Fire Hazards: Not available. Special Remarks on Explosion Hazards: Not available. Section 6: Accidental Release Measures Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal. Large Spill: Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Section 7: Handling and Storage Precautions: p. 3 Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and show the label when possible. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids. Storage: 96 Bommasandra Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Section 8: Exposure Controls/Personal Protection Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal Protection: Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: Not available. Section 9: Physical and Chemical Properties Physical state and appearance: Liquid. Odor: Ammoniacal. Taste: Not available. Molecular Weight: 129.25 g/mole Color: Colorless to light yellow. Clear pH (1% soln/water): Not available. Boiling Point: 127°C (260.6°F) Melting Point: <-50°C (-58°F) Critical Temperature: Not available. Specific Gravity: 0.742 (Water = 1) Vapor Pressure: Not available. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: Not available. Solubility: Not available. Section 10: Stability and Reactivity Data p. 4 Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Not available. Incompatibility with various substances: Reactive with oxidizing agents, acids. Corrosivity: Not available. Special Remarks on Reactivity: Incompatible with acid chlorides, acid anhydrides, carbon dioxide, copper, brass, rubber. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Absorbed through skin. Eye contact. Toxicity to Animals: LD50: Not available. LC50: Not available. Chronic Effects on Humans: Not available. Other Toxic Effects on Humans: 97 Bommasandra Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (corrosive, permeator), of eye contact (corrosive). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes skin irritation and possible burns. Eyes: Causes eye irritation and possible burns. Inhalation: May cause respiratory tracts and possible burns. Ingestion: May cause digestive tract irritation and possible burns. The toxicological properties of this substance have not been fully investigated. Section 12: Ecological Information Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information DOT Classification: p. 5 CLASS 3: Flammable liquid. Class 8: Corrosive material Identification: : Amines, Flammable, Corrosive, n.o.s. UNNA: 2733 PG: II Special Provisions for Transport: Not available. Section 15: Other Regulatory Information Federal and State Regulations: TSCA 8(b) inventory: N,N-Diisopropylethylamine Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). Other Classifications: WHMIS (Canada): Not controlled under WHMIS (Canada). DSCL (EEC): R11- Highly flammable. R34- Causes burns. S2- Keep out of the reach of children. S16- Keep away from sources of ignition - No smoking. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39- Wear suitable protective clothing, gloves and eye/face protection. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S46- If swallowed, seek medical advice immediately and show this container or label. HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 3 Reactivity: 0 Personal Protection: h National Fire Protection Association (U.S.A.): Health: 2 Flammability: 3 Reactivity: 0 Specific hazard: 98 Bommasandra Protective Equipment: Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles. Section 16: Other Information References: Not available. Other Special Considerations: Not available. Created: 10/11/2005 11:49 AM Last Updated: 11/06/2008 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. Material Safety Data Sheet N-Methyl-2-pyrrolidinone MSDS Section 1: Chemical Product and Company Identification Product Name: N-Methyl-2-pyrrolidinone Catalog Codes: SLM2023, SLM3397 CAS#: 872-50-4 RTECS: UY5790000 TSCA: TSCA 8(b) inventory: N-Methyl-2-pyrrolidinone CI#: Not available. Synonym: N-Methyl Pyrrolidone Chemical Name: N-Methyl-2-Pyrrolidinone Chemical Formula: C5H9NO Contact Information: CHEMTREC (24HR Emergency Telephone), call: 1-800-424-9300 International CHEMTREC, call: 1-703-527-3887 For non-emergency assistance, call: 1-281-441-4400 Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight {N-}Methyl{-2-}pyrrolidinone 872-50-4 100 Toxicological Data on Ingredients: N-Methyl-2-pyrrolidinone: ORAL (LD50): Acute: 3914 mg/kg [Rat]. 5130 mg/kg [Mouse]. DERMAL (LD50): Acute: 8000 mg/kg [Rabbit]. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator). Potential Chronic Health Effects: 99 Bommasandra CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to blood, kidneys, lymphatic system, Urinary system, bone marrow. Repeated or prolonged exposure to the substance can produce target organs damage. Section 4: First Aid Measures p. 2 Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Serious Skin Contact: Not available. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious Inhalation: Not available. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: Combustible. Auto-Ignition Temperature: 346.11°C (655°F) Flash Points: CLOSED CUP: 92.778°C (199°F). OPEN CUP: 95.556°C (204°F). Flammable Limits: LOWER: 1.3% UPPER: 9.5% Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: Not available. Special Remarks on Explosion Hazards: Not available. Section 6: Accidental Release Measures Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal. Large Spill: Combustible material. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Section 7: Handling and Storage Precautions: 100 Bommasandra Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. In case of p. 3 insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, reducing agents, acids, alkalis. Storage: Hygroscopic. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Do not store above 24°C (75.2°F). Preferably refrigerate. Section 8: Exposure Controls/Personal Protection Engineering Controls: Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal Protection: Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: TWA: 25 STEL: 75 (ppm) [United Kingdom (UK)] TWA: 103 STEL: 309 (mg/m3) [United Kingdom (UK)] TWA: 10 from AIHA TWA: 40 (mg/m3) from AIHA Consult local authorities for acceptable exposure limits. Section 9: Physical and Chemical Properties Physical state and appearance: Liquid. Odor: Amine like. Taste: Not available. Molecular Weight: 99.14 g/mole Color: Colorless to light yellow. pH (1% soln/water): Not available. Boiling Point: 202°C (395.6°F) Melting Point: -24°C (-11.2°F) Critical Temperature: 451°C (843.8°F) Specific Gravity: 1.026 (Water = 1) Vapor Pressure: 0 kPa (@ 20°C) Vapor Density: 3.4 (Air = 1) Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.5 Ionicity (in Water): Not available. Dispersion Properties: Not available. Solubility: Miscible with Castor Oil. Miscible with water, lower alcohols, ketones, ethyl acetate, chloroform and benzene. Moderately soluble in aliphatic hydrocarbons and dissolves many organic and inorganic compounds. p. 4 101 Bommasandra Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Excess heat, moisture, incompatibles Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, acids, alkalis. Slightly reactive to reactive with moisture. Corrosivity: Not available. Special Remarks on Reactivity: Hygroscopic. Incompatible with reducing agents, strong alkalies, strong mineral acids. Reacts with chlorinating agents (e.g. cobalt chloride, thionyl chloride, phosphorous oxychloride, pentachlorophosphorous to form the amide. Reacts with sulfur and carbon disulfide at high temperatures and pressures. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Toxicity to Animals: Acute oral toxicity (LD50): 3914 mg/kg [Rat]. Acute dermal toxicity (LD50): 8000 mg/kg [Rabbit]. Chronic Effects on Humans: MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. May cause damage to the following organs: blood, kidneys, lymphatic system, Urinary system, bone marrow. Other Toxic Effects on Humans: Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects (maternal effects - post implantation mortality, fetotoxicity) and birth defects based on animal. May affect genetic material. May cause cancer (tumorigenic) based on animal data. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes skin irritation. May be absorbed through skin. Eyes: Causes moderate eye irritation. Inhalation: Causes respiratory tract irritation. May affect respiration (dyspnea), gastrointestinal tract (abdominal pain, nausea, voiting and inflammation of gums and mouth, behavior/Central Nervous system (somnolence, muscel weakness, dizziness, drowsiness, headache), and urinary system. Ingestion: May cause gastrointestinal tract irritation with nausea, vomiting and diarrhea. May affect behavior/Central Nervous System (similar symptoms to inhalation) metabolism, blood and urinary tract. Section 12: Ecological Information Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available. p. 5 Section 13: Disposal Considerations Waste Disposal: 102 Bommasandra Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information DOT Classification: Not a DOT controlled material (United States). Identification: Not applicable. Special Provisions for Transport: Not applicable. Section 15: Other Regulatory Information Federal and State Regulations: Pennsylvania RTK: N-Methyl-2-pyrrolidinone Minnesota: N-Methyl-2-pyrrolidinone Massachusetts RTK: N-Methyl-2- pyrrolidinone New Jersey: N-Methyl-2-pyrrolidinone New Jersey spill list: N-Methyl-2-pyrrolidinone TSCA 8(b) inventory: NMethyl- 2-pyrrolidinone TSCA 4(a) final test rules: N-Methyl-2-pyrrolidinone TSCA 8(a) IUR: N-Methyl-2- pyrrolidinone TSCA 12(b) one time export: N-Methyl-2-pyrrolidinone SARA 313 toxic chemical notification and release reporting: N-Methyl-2- pyrrolidinone Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). DSCL (EEC): R36- Irritating to eyes. S2- Keep out of the reach of children. S46- If swallowed, seek medical advice immediately and show this container or label. HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 2 Reactivity: 0 Personal Protection: j National Fire Protection Association (U.S.A.): Health: 2 Flammability: 1 Reactivity: 0 Specific hazard: Protective Equipment: Not applicable. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles. Section 16: Other Information References: Not available. p. 6 Other Special Considerations: Not available. Created: 10/10/2005 10:47 AM Last Updated: 11/06/2008 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for 103 Bommasandra lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. Material Safety Data Sheet Sodium bicarbonate MSDS Section 1: Chemical Product and Company Identification Product Name: Sodium bicarbonate Catalog Codes: SLS3241, SLS2446, SLS3868 CAS#: 144-55-8 RTECS: VZ0950000 TSCA: TSCA 8(b) inventory: Sodium bicarbonate CI#: Not available. Synonym: Baking Soda; Bicarbonate of soda; Sodium acid carbonate; Monosodium carbonate; Sodium hydrogen carbonate; Carbonic acid monosodium salt Chemical Name: Sodium Bicarbonate Chemical Formula: NaHCO3 Contact Information: Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Sodium bicarbonate 144-55-8 100 Toxicological Data on Ingredients: Not applicable. Section 3: Hazards Identification Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure is not known to aggravate medical condition. Section 4: First Aid Measures Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. p. 2 Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin Contact: Not available. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious Inhalation: Not available. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious 104 Bommasandra person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: Non-flammable. Auto-Ignition Temperature: Not applicable. Flash Points: Not applicable. Flammable Limits: Not applicable. Products of Combustion: Not available. Fire Hazards in Presence of Various Substances: Not applicable. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: Not applicable. Special Remarks on Fire Hazards: When heated to decomposition it emits acrid smoke and irritating fumes. Special Remarks on Explosion Hazards: Not available. Section 6: Accidental Release Measures Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7: Handling and Storage Precautions: Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as acids. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Section 8: Exposure Controls/Personal Protection p. 3 Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: Not available. Section 9: Physical and Chemical Properties Physical state and appearance: Solid. Odor: Odorless. Taste: Saline. Alkaline. 105 Bommasandra Molecular Weight: 84.01g/mole Color: White. pH (1% soln/water): Not available. Boiling Point: Not available. Melting Point: Not available. Critical Temperature: Not available. Specific Gravity: Density: 2.159 (Water = 1) Vapor Pressure: Not applicable. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: See solubility in water. Solubility: Soluble in cold water. Slightly soluble in alcohol. Solubility in Water: 6.4, 7.6, 8.7, 10.0, 11.3, 12.7, 14.2, 16.5, 19.1 g/100 solution at 0, 10, 20, 30, 40, 50, 60, 80, adn 100 deg. C, respectively. Solubility in Water: 6.9, 8,2, 9.6, 11.1, 12.7, 14.5, 16.5, 19.7, and 23.6 g/100g water at 0, 10, 20, 30, 40, 50, 60, 80, 100 deg. C, respectively. Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Incompatible materials, Moisture. Stable in dry air, but slowly decomposes in moist air. Incompatibility with various substances: Reactive with acids. p. 4 Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Reacts with acids to form carbon dioxide. Dangerous reaction with monoammonium phosphate or a sodium-potassium alloy. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Inhalation. Ingestion. Toxicity to Animals: Acute oral toxicity (LD50): 3360 mg/kg [Mouse]. Chronic Effects on Humans: Not available. Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Sodium Bicarbonate as produced genetic effects in rats (unscheduled DNA synthesis). However, no affects have been found in humans. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: May cause mild skin irritation. Eyes: May cause mild eye irritation. Inhalation: May cause respiratory tract irritation. Symptoms may include coughing and sneezing. Ingestion: Symptoms of overexposure to Sodium Bicarbonate include thirst, abdominal pain, gastroenteritis, and inflammation of the digestive tract. Chronic Potential Health Effects: Skin: Repeated or prolonged skin contact may cause irritation, drying or cracking of the skin. Ingestion and Inhalation: Chronic toxicity usually occurs within 4 to 10 days following ingestion of very large amounts. Repeated or prolonged 106 Bommasandra ingestion or inhalation of large amounts may cause metabolic abnormalities, and sodium retention. Metabolic abnormalities such as acidosis, hypernatremia, hypochloremia, alkalosis, hypocalcemia, or sodium retention may affect the blood, kidneys, respiration (cyanosis, apnea secondary to metabolic acidosis or pulmonary edema), and cardiovascular system (tachycardia, hypotension). Severe toxicity may also affect behavior/central nervous system/nervous system. Neurological changes may result from metabolic abnormalities. These may include fatigue, irritability, dizziness, mental confusion, paresthesia, seizures, tetany, cerebral edema Medical Conditions Aggravated by Exposure: Persons with pre-existing skin conditions might have increased sensitivity. Predisposing conditions that contribute to a mild alkali syndrome include, renal disease, dehydration, adn electrolyte imbalance, hypertension, sarcoidosis, congestive heart failure, edema, or other sodium retaining conditions. Section 12: Ecological Information Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information p. 5 DOT Classification: Not a DOT controlled material (United States). Identification: Not applicable. Special Provisions for Transport: Not applicable. Section 15: Other Regulatory Information Federal and State Regulations: TSCA 8(b) inventory: Sodium bicarbonate Other Regulations: Not available. Other Classifications: WHMIS (Canada): Not controlled under WHMIS (Canada). DSCL (EEC): This product is not classified according to the EU regulations. Not applicable. HMIS (U.S.A.): Health Hazard: 1 Fire Hazard: 0 Reactivity: 0 Personal Protection: E National Fire Protection Association (U.S.A.): Health: 1 Flammability: 0 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. Section 16: Other Information References: Not available. 107 Bommasandra Other Special Considerations: Not available. Created: 10/10/2005 08:26 PM Last Updated: 11/06/2008 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. Material Safety Data Sheet Hexanoic Acid, Sodium Salt MSDS Section 1: Chemical Product and Company Identification Product Name: Hexanoic Acid, Sodium Salt Catalog Codes: SLH3049 CAS#: 10051-44-2 RTECS: Not available. TSCA: TSCA 8(b) inventory: Hexanoic Acid, Sodium Salt CI#: Not available. Synonym: Sodium Hexanoate; Caproic Acid, Sodium Salt; n-Caproic Acid, Sodium Salt; Sodium Caproate Chemical Name: Not available. Chemical Formula: C6-H11-O2-Na Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Hexanoic Acid, Sodium Salt 10051-44-2 100 Toxicological Data on Ingredients: Hexanoic Acid, Sodium Salt LD50: Not available. LC50: Not available. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Slightly hazardous in case of ingestion. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure is not known to aggravate medical condition. Section 4: First Aid Measures Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention. p. 2 Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated 108 Bommasandra clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious Inhalation: Not available. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: May be combustible at high temperature. Auto-Ignition Temperature: Not available. Flash Points: Not available. Flammable Limits: Not available. Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of heat. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: As with most organic solids, fire is possible at elevated temperatures Special Remarks on Explosion Hazards: Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Section 6: Accidental Release Measures Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7: Handling and Storage Precautions: p. 3 Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and show the label when possible. Avoid contact with skin and eyes. Keep away from incompatibles 109 Bommasandra such as oxidizing agents. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F). Refrigerate. Section 8: Exposure Controls/Personal Protection Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: Not available. Section 9: Physical and Chemical Properties Physical state and appearance: Solid. (Powdered solid.) Odor: Not available. Taste: Not available. Molecular Weight: 138.14 g/mole Color: Not available. pH (1% soln/water): Not available. Boiling Point: Not available. Melting Point: Not available. Critical Temperature: Not available. Specific Gravity: Not available. Vapor Pressure: Not applicable. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: See solubility in water. Solubility: Soluble in cold water, hot water. Section 10: Stability and Reactivity Data p. 4 Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Excess heat, incompatible materials Incompatibility with various substances: Reactive with oxidizing agents. Corrosivity: Not available. Special Remarks on Reactivity: Not available. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Inhalation. Ingestion. Toxicity to Animals: LD50: Not available. LC50: Not available. Chronic Effects on Humans: Not available. 110 Bommasandra Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of inhalation. Slightly hazardous in case of ingestion. Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes skin irritation. Eyes: Causes eye irritation. Inhalation: Causes respiratory tract and mucous membrane irritation. Ingestion: May be harmful if swallowed. May affect behavior'/central nervous system (irritabililtiy, confusion, convulsions), blood (changes in blood serum composition). Chronic Potential Health Effects: Ingestion: Repeated or prolonged ingestion may affect behavior/central nevous system Note: The above toxicological information was extrapolated from Hexanoic acid. Section 12: Ecological Information Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information DOT Classification: Not a DOT controlled material (United States). p. 5 Identification: Not applicable. Special Provisions for Transport: Not applicable. Section 15: Other Regulatory Information Federal and State Regulations: TSCA 8(b) inventory: Hexanoic Acid, Sodium Salt Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): Not controlled under WHMIS (Canada). DSCL (EEC): R36/37/38- Irritating to eyes, respiratory system and skin. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36- Wear suitable protective clothing. HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 1 Reactivity: 0 Personal Protection: E National Fire Protection Association (U.S.A.): Health: 2 Flammability: 1 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles. Section 16: Other Information 111 Bommasandra References: Not available. Other Special Considerations: Not available. Created: 10/09/2005 05:43 PM Last Updated: 11/06/2008 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. Material Safety Data Sheet Sodium methoxide MSDS Section 1: Chemical Product and Company Identification Product Name: Sodium methoxide Catalog Codes: SLS4279, SLS3199 CAS#: 124-41-4 RTECS: PC3570000 TSCA: TSCA 8(b) inventory: Sodium methoxide CI#: Not applicable. Synonym: Methanol, sodium salt; Sodium Methylate Chemical Name: Sodium methoxide Chemical Formula: CH3ONa Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Sodium methoxide 124-41-4 100 Toxicological Data on Ingredients: Sodium methoxide: ORAL (LD50): Acute: 2037 mg/kg [Rat]. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (corrosive, irritant, sensitizer, permeator), of eye contact (irritant, corrosive), of ingestion, of inhalation. The amount of tissue damage depends on length of contact. Eye contact can result in corneal damage or blindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking, unconsciousness or death. Potential Chronic Health Effects: Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated exposure of the eyes to a low level of dust can produce eye irritation. Repeated skin exposure can produce local skin destruction, or 112 Bommasandra dermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation or lung damage. Section 4: First Aid Measures p. 2 Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention immediately. Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: Flammable. Auto-Ignition Temperature: 88°C (190.4°F) Flash Points: CLOSED CUP: 33°C (91.4°F). Flammable Limits: LOWER: 7.3% UPPER: 36% Products of Combustion: These products are carbon oxides (CO, CO2). Fire Hazards in Presence of Various Substances: Highly flammable in presence of moisture. Flammable in presence of open flames and sparks, of heat. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: Flammable solid. Moisture reactive material. SMALL FIRE: Obtain advice on use of water. Use DRY chemical powder. LARGE FIRE: Use water spray or fog. Do not use water jet. Special Remarks on Fire Hazards: Dangerous. It ignites spontaneously in moist air. This material is pyrophoric (ignites spontaneously in air) at temperatures approximately 50 deg. C and above. 113 Bommasandra Special Remarks on Explosion Hazards: Material in powder form, capable of creating a dust explosion. Sodium methylate and Methyl azide + Dimethyl Malonate may cause an explosion. Sodium Methylate and Perchloryl Fluoride + Methyl alcohol may cause an explosion. To rapid of an addition of Sodium Methylate to a mixture of chloroform and methanol may cause an explosion. Section 6: Accidental Release Measures p. 3 Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Large Spill: Corrosive solid. Flammable solid that, in contact with water, emits flammable gases. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Cover with dry earth, sand or other non-combustible material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call for assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Section 7: Handling and Storage Precautions: Keep under inert atmosphere. Keep container dry. Do not ingest. Do not breathe dust. Never add water to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids, moisture. Storage: Moisture sensitive. Air Sensitive. Store in a segregated and approved area. Keep in a cool and ventilated area away from combustible materials. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Section 8: Exposure Controls/Personal Protection Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Splash goggles. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Vapor and dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: Exposure LImit Information for Dust or Particulates Not Otherwise Classified: TWA: 10 (mg/m3) from ACGIH (TLV) [United 114 Bommasandra States] Inhalation Total. TWA: 3 (mg/m3) from ACGIH (TLV) [United States] Inhalation Respirable. TWA: 15 (mg/m3) from OSHA (PEL) [United States] Inhalation Total. TWA: 5 (mg/m3) from OSHA (PEL) [United States] Inhalation Respirable.Consult local authorities for acceptable exposure limits. Section 9: Physical and Chemical Properties Physical state and appearance: Solid. (Solid powder. Amorphous solid powder or lumps. ) Odor: Not available. Taste: Not available. Molecular Weight: 54.03 g/mole Color: White. pH (1% soln/water): Not available. p. 4 Boiling Point: Not available. Melting Point: Decomposition temperature: >126°C (258.8°F) Critical Temperature: Not available. Specific Gravity: 1.1 (Water = 1) Vapor Pressure: Not applicable. Vapor Density: 1.1 (Air = 1) Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: See solubility in water, methanol. Solubility: Soluble in cold water, methanol. Soluble in ethanol. Decomposes/reacts in water. Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Excess heat, air, moisture, water,incompatible materials. Incompatibility with various substances: Reactive with oxidizing agents, acids, moisture. The product reacts violently with water to emit flammable but non toxic gases. Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Moisture sensitive Air sensitive. Also incompatible with chlorinated solvents, chloroform, 4- chloronitrobenzene, perfluorocyclopropane, liquid metals. Attacks some forms of plastics, rubbers, and coatings. Sodium Methylate + water produces a caustic soda solution and a solution of methyl alcohol. The reaction is not violent. When heated to decomposition it emits toxic fumes. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion. Toxicity to Animals: Acute oral toxicity (LD50): 2037 mg/kg [Rat]. Chronic Effects on Humans: Not available. Other Toxic Effects on Humans: Hazardous in case of skin contact (corrosive, irritant, sensitizer, permeator), of eye contact (corrosive), of ingestion, of inhalation (lung corrosive). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. 115 Bommasandra Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Casues severe skin irritation and burns. Eyes: Causes severe eye irritation and burns. May cause eye injury Inhalation: Material is destructive to tissue of the mucous membranes and upper respiratory tract. It p. 5 may cause severe irritation to the respiratory tract and chemical burns to the respiratory tract. Symptoms may include sore throat, burning sensation, coughing, wheezing, labored breathing, and possible pulmonary edema. Ingeston: Causes mouth, esophagus, pharyns, and gastrointestinal tract irritation and burns. Symptoms may include sore throat, vomiting diarrhea, and abdominal pain. It may also affect respiration(dyspnea), and behavior (ataxia). Chronic Potential Health Effects: Repeated or prolonged skin contact may cause dermitits, an allergic reaction.It may cause severe and permanent damage to the digestive tract. Section 12: Ecological Information Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information DOT Classification: CLASS 4.2: Spontaneously combustible substance. Class 8: Corrosive material Identification: : Sodium methylate UNNA: 1431 PG: II Special Provisions for Transport: Not available. Section 15: Other Regulatory Information Federal and State Regulations: Connecticut hazardous material survey.: Sodium methoxide Illinois toxic substances disclosure to employee act: Sodium methoxide Illinois chemical safety act: Sodium methoxide New York release reporting list: Sodium methoxide Pennsylvania RTK: Sodium methoxide Massachusetts RTK: Sodium methoxide Massachusetts spill list: Sodium methoxide New Jersey: Sodium methoxide New Jersey spill list: Sodium methoxide Louisiana spill reporting: Sodium methoxide California Director's List of Hazardous Substances: Sodium methoxide TSCA 8(b) inventory: Sodium methoxide CERCLA: Hazardous substances.: Sodium methoxide: 1000 lbs. (453.6 kg) Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS B-6: Reactive and very flammable material. CLASS E: Corrosive solid. DSCL (EEC): 116 Bommasandra HMIS (U.S.A.): Health Hazard: 2 p. 6 Fire Hazard: 2 Reactivity: 2 Personal Protection: j National Fire Protection Association (U.S.A.): Health: 3 Flammability: 2 Reactivity: 2 Specific hazard: Protective Equipment: Gloves. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles. Section 16: Other Information References: -SAX, N.I. Dangerous Properties of Indutrial Materials. Toronto, Van NostrandReinold, 6e ed. 1984. -The Sigma-Aldrich Library of Chemical Safety Data, Edition II. Other Special Considerations: Not available. Created: 10/10/2005 08:34 PM Last Updated: 11/06/2008 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. Material Safety Data Sheet MOPS MSDS Section 1: Chemical Product and Company Identification Product Name: MOPS Catalog Codes: SLM2587 CAS#: 1132-61-2 RTECS: QE9104530 TSCA: TSCA 8(b) inventory: MOPS CI#: Not available. Synonym: 3(N-Morpholino)propanesulfonic acid Chemical Name: MOPS, Biological Buffer Chemical Formula: C7-H14-N-O4-S CHEMTREC (24HR Emergency Telephone), call: 1-800-424-9300 International CHEMTREC, call: 1-703-527-3887 For non-emergency assistance, call: 1-281-441-4400 117 Bommasandra Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight MOPS 1132-61-2 100 Toxicological Data on Ingredients: MOPS: ORAL (LD50): Acute: >316 mg/kg [Quail]. Section 3: Hazards Identification Potential Acute Health Effects: Very hazardous in case of eye contact (irritant). Hazardous in case of inhalation. Inflammation of the eye is characterized by redness, watering, and itching. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage. Section 4: First Aid Measures Eye Contact: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention. p. 2 Skin Contact: No known effect on skin contact, rinse with water for a few minutes. Serious Skin Contact: Not available. Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention. Serious Inhalation: Not available. Ingestion: Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: May be combustible at high temperature. Auto-Ignition Temperature: Not available. Flash Points: Not available. Flammable Limits: Not available. Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Fire Hazards in Presence of Various Substances: Not available. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: Material in powder form, capable of creating a dust explosion. Special Remarks on Explosion Hazards: Not available. Section 6: Accidental Release Measures Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. 118 Bommasandra Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7: Handling and Storage Precautions: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Avoid contact with eyes In case of insufficient ventilation, wear suitable respiratory equipment If ingested, seek medical advice immediately and show the container or the label. Storage: Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents. p. 3 Section 8: Exposure Controls/Personal Protection Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Splash goggles. Lab coat. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: Not available. Section 9: Physical and Chemical Properties Physical state and appearance: Solid. (Crystalline solid.) Odor: Not available. Taste: Not available. Molecular Weight: 209.26 g/mole Color: White. pH (1% soln/water): Not available. Boiling Point: Decomposes. Melting Point: 284°C (543.2°F) Critical Temperature: Not available. Specific Gravity: Not available. Vapor Pressure: Not applicable. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: See solubility in water. Solubility: Soluble in cold water. Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. 119 Bommasandra Conditions of Instability: Not available. Incompatibility with various substances: Not available. Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Not available. p. 4 Special Remarks on Corrosivity: Not available. Polymerization: No. Section 11: Toxicological Information Routes of Entry: Eye contact. Inhalation. Toxicity to Animals: Acute oral toxicity (LD50): >316 mg/kg [Quail]. Chronic Effects on Humans: The substance is toxic to lungs, mucous membranes. Other Toxic Effects on Humans: Hazardous in case of inhalation. Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. Special Remarks on other Toxic Effects on Humans: Not available. Section 12: Ecological Information Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The products of degradation are more toxic. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: Section 14: Transport Information DOT Classification: Not a DOT controlled material (United States). Identification: Not applicable. Special Provisions for Transport: Not applicable. Section 15: Other Regulatory Information Federal and State Regulations: TSCA 8(b) inventory: MOPS Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). Other Classifications: WHMIS (Canada): CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS D-2A: Material causing other toxic effects (VERY TOXIC). DSCL (EEC): R41- Risk of serious damage to eyes. p. 5 HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 1 Reactivity: 0 Personal Protection: j National Fire Protection Association (U.S.A.): Health: 2 Flammability: 1 Reactivity: 0 Specific hazard: Protective Equipment: Not applicable. Lab coat. Wear appropriate respirator when ventilation is inadequate. Splash goggles. Section 16: Other Information References: Not available. Other Special Considerations: Not available. 120 Bommasandra Created: 10/11/2005 01:29 PM Last Updated: 11/06/2008 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. Material Safety Data Sheet Cysteamine Hydrochloride MSDS Section 1: Chemical Product and Company Identification Product Name: Cysteamine Hydrochloride Catalog Codes: SLC1327 CAS#: 156-57-0 RTECS: KJ0200000 TSCA: TSCA 8(b) inventory: Cysteamine Hydrochloride CI#: Not available. Synonym: 2-Aminoethanethiol Hydrochloride; 2- Mercaptoethylamine Hydrochloride. Chemical Name: Cysteamine Hydrochloride Chemical Formula: C2-H7-N-S.HCl Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Cysteamine Hydrochloride 156-57-0 100 Toxicological Data on Ingredients: Cysteamine Hydrochloride: ORAL (LD50): Acute: 1352 mg/kg [Mouse]. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure is not known to aggravate medical condition. Section 4: First Aid Measures Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention. Skin Contact: p. 2 In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated 121 Bommasandra clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious Inhalation: Not available. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: May be combustible at high temperature. Auto-Ignition Temperature: Not available. Flash Points: CLOSED CUP: Higher than 93.3°C (200°F). Flammable Limits: Not available. Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...). Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of heat. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: Not available. Special Remarks on Explosion Hazards: Not available. Section 6: Accidental Release Measures Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7: Handling and Storage Precautions: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In p. 3 case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the 122 Bommasandra container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, moisture. Storage: HYGROSCOPIC. Keep container tightly closed and store protected from moisture. Keep container in a cool, well-ventilated area. Refrigerate. Do not store above 4°C (39.2°F). If possible, store with a dessicant. Section 8: Exposure Controls/Personal Protection Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: Not available. Section 9: Physical and Chemical Properties Physical state and appearance: Solid. (Crystals solid. Powdered solid.) Odor: Not available. Taste: Not available. Molecular Weight: 113.61 g/mole Color: White. pH (1% soln/water): Not available. Boiling Point: Not available. Melting Point: 67°C (152.6°F) Critical Temperature: Not available. Specific Gravity: Not available. Vapor Pressure: Not applicable. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: See solubility in water. Solubility: Soluble in cold water, hot water. Section 10: Stability and Reactivity Data p. 4 Stability: The product is stable. Instability Temperature: Not available. Conditions of Instability: Excess heat, moisture, incompatible materials (strong oxidizers). Incompatibility with various substances: Reactive with oxidizing agents, moisture. Corrosivity: Not available. Special Remarks on Reactivity: Hygroscopic. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Inhalation. Ingestion. Toxicity to Animals: Acute oral toxicity (LD50): 1352 mg/kg [Mouse]. 123 Bommasandra Chronic Effects on Humans: Not available. Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: May affect genetic material based on animal data. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: May cause skin irritation. Eye: Dust may cause eye irritation. Inhalation: Dust may cause respiratory tract irritation. Ingestion: May be harmful if swallowed. May affect behavior (RTECS Mouse LDL -subcutaneous) The toxicological properties of this substance have not been fully investigated. Chronic Potential Health Effects: no data found. Section 12: Ecological Information Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: Section 14: Transport Information DOT Classification: Not a DOT controlled material (United States). Identification: Not applicable. Special Provisions for Transport: Not applicable. p. 5 Section 15: Other Regulatory Information Federal and State Regulations: TSCA 8(b) inventory: Cysteamine Hydrochloride Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): Not controlled under WHMIS (Canada). DSCL (EEC): R22- Harmful if swallowed. S37- Wear suitable gloves. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). HMIS (U.S.A.): Health Hazard: 2 Fire Hazard: 1 Reactivity: 0 Personal Protection: E National Fire Protection Association (U.S.A.): Health: 1 Flammability: 0 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles. Section 16: Other Information References: Not available. Other Special Considerations: Not available. Created: 10/09/2005 05:03 PM Last Updated: 11/06/2008 12:00 PM 124 Bommasandra The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. Material Safety Data Sheet 4-Dimethylaminopyridine MSDS Section 1: Chemical Product and Company Identification Product Name: 4-Dimethylaminopyridine Catalog Codes: SLD1903 CAS#: 1122-58-3 RTECS: US9230000 TSCA: TSCA 8(b) inventory: 4-Dimethylaminopyridine CI#: Not available. Synonym: DMAP; gamma-(Dimethylamino)pyaridine; p- Dimethylaminopyridine Chemical Name: Pyridine, 4-(dimethylamino)- Chemical Formula: C7-H10-N2 Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight {4-}Dimethylaminopyridine 1122-58-3 100 Toxicological Data on Ingredients: 4-Dimethylaminopyridine: ORAL (LD50): Acute: 250 mg/kg [Rat]. 190 mg/kg [Rat]. DERMAL (LD50): Acute: 13 mg/kg [Rabbit]. Section 3: Hazards Identification Potential Acute Health Effects: Very hazardous in case of skin contact (permeator). Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation (lung irritant). Severe over-exposure can result in death. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to mucous membranes, skin, central nervous system (CNS), eye, lens or cornea. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. Section 4: First Aid Measures p. 2 Eye Contact: 125 Bommasandra Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention. Skin Contact: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Serious Ingestion: Not available. Section 5: Fire and Explosion Data Flammability of the Product: May be combustible at high temperature. Auto-Ignition Temperature: 420°C (788°F) Flash Points: CLOSED CUP: 110°C (230°F). Flammable Limits: Not available. Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of open flames and sparks. Non-explosive in presence of heat. Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: As with most organic solids, fire is possible at elevated temperatures Special Remarks on Explosion Hazards: Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Section 6: Accidental Release Measures Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Large Spill: Poisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to 126 Bommasandra reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call for assistance on disposal. p. 3 Section 7: Handling and Storage Precautions: Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Section 8: Exposure Controls/Personal Protection Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: Not available. Section 9: Physical and Chemical Properties Physical state and appearance: Solid. (Crystals solid.) Odor: Odorless. Taste: Not available. Molecular Weight: 122.17 g/mole Color: White. pH (1% soln/water): Not available. Boiling Point: 162°C (323.6°F) @ 50 mm Hg Melting Point: 110°C (230°F) - 113 C Critical Temperature: Not available. Specific Gravity: Not available. Vapor Pressure: Not applicable. Vapor Density: Not available. Volatility: Not available. Odor Threshold: Not available. Water/Oil Dist. Coeff.: Not available. Ionicity (in Water): Not available. Dispersion Properties: Not available. Solubility: p. 4 Slightly soluble in cold water. Solubility in Water: 7.6 g/100 ml @ 25 deg. C Section 10: Stability and Reactivity Data Stability: The product is stable. Instability Temperature: Not available. 127 Bommasandra Conditions of Instability: Excess heat, incompatible materials, dust generation Incompatibility with various substances: Reactive with oxidizing agents, acids. Corrosivity: Not available. Special Remarks on Reactivity: Not available. Special Remarks on Corrosivity: Not available. Polymerization: Will not occur. Section 11: Toxicological Information Routes of Entry: Absorbed through skin. Dermal contact. Inhalation. Ingestion. Toxicity to Animals: Acute oral toxicity (LD50): 190 mg/kg [Rat]. Acute dermal toxicity (LD50): 13 mg/kg [Rabbit]. Chronic Effects on Humans: May cause damage to the following organs: mucous membranes, skin, central nervous system (CNS), eye, lens or cornea. Other Toxic Effects on Humans: Very hazardous in case of skin contact (permeator). Hazardous in case of skin contact (irritant), of ingestion, of inhalation (lung irritant). Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available. Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Causes skin irritation. Very toxic if absorbed through the skin. It may even be fatal if absorbed through the skin. Eyes: Causes severe eye irritation. Inhalation: Causes respiratory tract irritation. Ingestion: Harmful if swallowed. Symptoms of overexposure by ingestion or skin absorption may include headache, nausea, disorientation, weakness, and convulsions. Section 12: Ecological Information Ecotoxicity: Not available. BOD5 and COD: Not available. Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself. Special Remarks on the Products of Biodegradation: Not available. Section 13: Disposal Considerations Waste Disposal: p. 5 Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14: Transport Information DOT Classification: CLASS 6.1: Poisonous material. Identification: : Toxic Solid, Organic (4-Dimethylaminopyridine) UNNA: 2811 PG: I Special Provisions for Transport: Not available. Section 15: Other Regulatory Information Federal and State Regulations: TSCA 8(b) inventory: 4-Dimethylaminopyridine Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications: WHMIS (Canada): CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). DSCL (EEC): R25- Toxic if swallowed. R27- Very toxic in contact with skin. R36/37/38- Irritating to eyes, respiratory system and skin. S26- In 128 Bommasandra case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28- After contact with skin, wash immediately with plenty of water. S36/37/39- Wear suitable protective clothing, gloves and eye/face protection. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). HMIS (U.S.A.): Health Hazard: 3 Fire Hazard: 1 Reactivity: 0 Personal Protection: E National Fire Protection Association (U.S.A.): Health: 3 Flammability: 1 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles. Section 16: Other Information References: Not available. Other Special Considerations: Not available. Created: 10/10/2005 08:17 PM Last Updated: 11/06/2008 12:00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume p. 6 no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com has been advised of the possibility of such damages. PRODUCT: DIPOTASSIUM HYDROGEN PHOSPHATE SECTION 1: MATERIAL IDENTIFICATION Product Name: Testmix CP0219 Synonyms: Albumin, Uracil, Butylparaben, Diazepam, and Dipotassium hydrogen phosphate in a mixture of Acetonitrile and Water. Acetonitrile is also known as Ethane Nitrile and Methyl Cyanide. SECTION 2: COMPOSITION An ampoule/vial containing the following: Approximate NTP IARC Component CAS Number Concentration Carcinogen Status Carcinogen Status Albumin 94349-60-7 10 g/l not listed not listed Uracil 66-22-8 20 mg/l not listed not listed n-Butylparabene 94-26-8 20 mg/l not listed not listed Diazepam 439-14-5 50 mg/l not listed not listed Dipotassium hydrogen phosphate 7758-11-4 1.22 g/l not listed not listed Water 7732-18-5 90% not listed not listed Acetonitrile 75-05-8 10% not listed not listed 129 Bommasandra WARNING: This product contains Diazepam [CAS# 439-14-5] a chemical known to the State of California to cause birth defects or other reproductive harm. NOTE: Unless otherwise noted, the information below pertains only to the Acetonitrile solvent in the ampoule/vial. SECTION 3: HAZARD IDENTIFICATION Emergency Overview: Colorless liquid. Flash Point: 2 deg C. Flammable liquid and vapor. Harmful or fatal if swallowed, inhaled, or absorbed through the skin. May cause eye and skin irritation. Target Organs: blood, kidneys, central nervous system, liver, and cardiovascular system. Metabolized to cyanide in the body, which may cause headache, dizziness, weakness, unconsciousness, convulsions, coma and possible death. May be harmful to the environment if released in large amounts. Potential Health Effects Inhalation: Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. Causes upper respiratory tract irritation. May be metabolized to cyanide which in turns act by inhibiting cytochrome oxidase impairing cellular respiration. May cause tissue anoxia, characterized by weakness, headache, dizziness, confusion, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), weak and irregular heart beat, collapse, unconsciousness, convulsions, coma and death. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause effects similar to those for inhalation exposure. Skin Contact: Causes mild skin irritation. Harmful if absorbed through the skin. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. Prolonged or repeated skin contact may cause dermatitis. Eye Contact: May cause irritation, redness, and pain. Carcinogen Status: NTP: Not listed IARC: Not listed SECTION 4: FIRST AID INFORMATION Inhalation: Get medical attention immediately. Remove to fresh air. If breathing is difficult, give oxygen. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Do NOT use mouth-to- mouth resuscitation. Ingestion: If swallowed, get medical attention immediately. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Skin Contact: In case of contact, immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention immediately. Wash clothing before reuse. Eye Contact: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical attention immediately. Do NOT allow victim to rub or keep eyes closed. MSDS# 1002-219 Revision 1 Effective Date 10/18/02 Page 2 of 4 SECTION 5: FIRE-FIGHTING INFORMATION Fire: Flash point (closed cup): 2C (36F) Autoignition temperature: 524C (975F) Flammable limits in air % by volume: Lower = 4.4 Upper = 16.0 NFPA Rating: health-2; flammability-3; reactivity-0 Explosion: Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Vapors can flow along surfaces to distant ignition source and flash back. Sealed containers may rupture when heated. Contact with strong oxidizers may cause fire. Sensitive to static discharge. Fire Extinguishing Media: Dry chemical, foam or carbon dioxide. Water may be ineffective. Water spray may be used to keep fire exposed containers cool, dilute spills to nonflammable mixtures, protect personnel attempting to stop leak and disperse vapors. SECTION 6: ACCIDENTAL RELEASE MEASURES Use proper personal protective equipment as indicated in Section 8. Ventilate area of leak or spill. Remove all sources of ignition. Absorb spill with inert material (e.g. vermiculite, sand or earth), scoop up with a nonsparking tool, then place into a suitable container for disposal. Do not flush to sewer! SECTION 7: HANDLING AND STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes. Avoid ingestion and inhalation. Storage: Keep away from heat, sparks, flame and sources of ignition. Store in a tightly closed container. Store in a cool, dry, wellventilated area away from incompatible substances. SECTION 8: EXPOSURE CONTROL/PERSONAL PROTECTIVE EQUIPMENT Airborne Exposure Limits: United States - OSHA Permissible Exposure Limit (PEL): 40 ppm (TWA) United States - ACGIH Threshold Limit Value (TLV): 40 ppm (TWA) ; 60 ppm (STEL) Europe –80/1107/EEC: 70 ppm (TWA); 40 mg/m3 (TWA) 130 Bommasandra Australia: Time-weighted average 40 ppm (70 mg/m3), short term exposure limit 60 ppm, Skin JAN1993 The Netherlands: MAC-TGG 40 ppm (70 mg/m3), JAN1999 Personal Protective Equipment Eye Protection: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Maintain eye wash fountain and quick-drench facilities in work area. Skin Protection: Wear impervious gloves, apron, and/or clothing. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Use a NIOSH or European Standard EN 149 approved respirator when necessary. Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, "Industrial Ventilation, A Manual of Recommended Practices", most recent edition, for details. SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES Appearance: Clear, colorless liquid Boiling Point: 82C (180F) Odor: Ether odor Melting Point: -46 (-51F) Solubility: Miscible in water Vapor Density: 1.42 (Air=1) Specific Gravity: 0.79 (Water = 1) Vapor Pressure (mm Hg): 73 @ 20C (68F) pH: Not available. Evaporation Rate: 5.79 (Butyl Acetate = 1) Molecular Formula: C2H3N % Volatiles by Volume: 100 Molecular Weight: 41.05 MSDS# 1002-219 Revision 1 Effective Date 10/18/02 Page 3 of 4 SECTION 10: STABILITY AND REACTIVITY DATA Stability: Stable at room temperature in sealed containers. Hazardous Decomposition Products: Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur. Incompatibilities: Highly reactive with oxidizing agents, reducing agents, acids, alkalis. Conditions to Avoid: Incompatible materials, ignition sources, excess heat, exposure to moist air or water, oxidizers. SECTION 11: TOXICOLOGICAL INFORMATION RTECS#: AL7700000 for CAS# 75-05-8: LD50/LC50: Oral, mouse: LD50 = 269 mg/kg Inhalation, mouse: LC50 = 2693 ppm 1/H Oral, rabbit: LD50 = 50 mg/kg Inhalation, rabbit: LC50 = 2828 ppm 4/H Skin, rabbit: LD50 = 1250uL/kg Carcinogenicity: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Toxicity to Reproductive System: Tests on laboratory animals for reproductive effects are cited in Registry of Toxic Effects on Chemical Substances (RTECS). Teratogenic Effects: Not available. Mutagenicity: Tests on laboratory animals for mutagenic effects are cited in Registry of Toxic Effects of Chemical Substances (RTECS). SECTION 12: ECOLOGICAL INFORMATION Environmental Fate: When released into the soil, this material may biodegrade to a moderate extent. When released into the soil, this material is expected to leach into groundwater. When released into the soil, this material is expected to evaporate to a moderate extent. When released to water, this material may evaporate to a moderate extent. This material is not expected to significantly bioaccumulate. When released into the air, this material is not expected to react with photochemically produced hydroxyl radicals. When released into the air, this material may be removed from the atmosphere to a moderate extent by wet deposition. When released into the air, this material is expected to have a half-life of greater than 30 days. Environmental Toxicity: This material is not expected to be toxic to aquatic life. The LC50/96-hour values for fish are over 100 mg/l. SECTION 13: DISPOSAL GUIDELINES Dispose in compliance with federal, state, and local regulations. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. USEPA RCRA waste numbers U003 and D001. The information offered here is for the product as shipped. Use and/or alterations to the product such as mixing with other materials may significantly change the characteristics of the material and alter the RCRA classification and the proper disposal 131 Bommasandra method. SECTION 14: TRANSPORT INFORMATION Ship in accordance with all applicable local, State, Federal, and International transportation regulations. The following is a summary only. Check regulations for complete information: United States (Land, D.O.T.) International (Air, I.C.A.O.) Proper Shipping Name: Acetonitrile Proper Shipping Name: Acetonitrile Hazard Class: 3 Hazard Class: 3 UN/NA: UN1648 UN/NA: UN1648 Packing Group: II Packing Group: II MSDS# 1002-219 Revision 1 Effective Date 10/18/02 Page 4 of 4 SECTION 15: REGULATORY INFORMATION US Federal TSCA: CAS# 75-05-8 is listed on the TSCA inventory. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No Reactivity: No US State CAS# 75-05-8 can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. California Proposition 65: Not regulated. Other Regulations EC Hazard Symbols: F – Highly Flammable and T - Toxic EC Risk and Safety Phrases: Risk Phrases: R 11 Highly flammable R23/24/25 Toxic by inhalation, in contact with skin, and if swallowed. Safety Phrases: S 16 Keep away from sources of ignition - No smoking. S 27 Take off immediately all contaminated clothing. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Australian Hazchem Code: 2WE SECTION 16: OTHER INFORMATION NOTE: Unless otherwise noted, the information above pertains only to the Acetonitrile solvent in the ampoule. Rev. 1 - Corrected component name for Dipotassium hydrogen phosphate and CAS numbers. This MSDS was prepared in accordance with ANSI Z400.1-1993 and 91/155/EEC recommended formats. The information contained herein is believed to be accurate, but does not purport to be all-inclusive and shall be used only as a guide. Varian, Inc., does not guarantee said information is accurate or complete, nor shall any of this information constitute a warranty, whether expressed or implied, as to the safety of the goods, the merchantability of the goods, or the fitness of the goods for a particular purpose. It is the user’s responsibility to determine the suitability of this information and to assure the adoption of necessary precautions. Varian, Inc. shall not be held liable for any damage resulting from handling or from contact with the above product, nor for the results obtained, or for incidental or consequential damage arising from the use of these data. No freedom from infringement of any patent, copyright or trademark is to be inferred. Material Safety Data Sheet ETHYLDIISOPROPYLAMINE (EDIPA) Product code: 001546 Version 1.0 Issued on: 07/27/2011 Page: 1 / 9 1. PRODUCT AND COMPANY IDENTIFICATION Company Arkema Inc. 132 Bommasandra 900 First Avenue King of Prussia, Pennsylvania 19406 Thio and Fine Chemicals Customer Service Telephone Number: (800) 628-4453 (Monday through Friday, 8:30 AM to 5:30 PM EST) Emergency Information Transportation: CHEMTREC: (800) 424-9300 (24 hrs., 7 days a week) Medical: Rocky Mountain Poison Center: (866) 767-5089 (24 hrs., 7 days a week) Product Information Product name: ETHYLDIISOPROPYLAMINE (EDIPA) Synonyms: EDIPA Molecular formula: C8H19N Chemical family: Alkyl amine Product use: Chemical intermediate 2. HAZARDS IDENTIFICATION Emergency Overview Color: colourless, light yellow Physical state: liquid Odor: strong, Amines WARNING! FLAMMABLE LIQUID AND VAPOR. CAUSES EYE IRRITATION. HARMFUL IF SWALLOWED. PROLONGED OR REPEATED CONTACT MAY DRY SKIN AND CAUSE IRRITATION. Potential Health Effects Primary routes of exposure: Inhalation and skin contact. Signs and symptoms of acute exposure: 133 Bommasandra Causes serious eye irritation. If swallowed, may cause severe irritation and injury to the mouth, throat and digestive tract. Repeated exposure may cause skin dryness or cracking. Skin: Slightly irritating. (based on animal studies) Eyes: Material Safety Data Sheet ETHYLDIISOPROPYLAMINE (EDIPA) Product code: 001546 Version 1.0 Issued on: 07/27/2011 Page: 2 / 9 Severely irritating. (based on components) Ingestion: Slightly toxic to moderately toxic. (based on animal studies) 3. COMPOSITION/INFORMATION ON INGREDIENTS Chemical Name CAS-No. Wt/Wt OSHA Hazardous 2-Propanamine, N-ethyl-N-(1-methylethyl)- 7087-68-5 > 99 % Y The substance(s) marked with a "Y" in the Hazard column above, are those identified as hazardous chemicals under the criteria of the OSHA Hazard Communication Standard (29 CFR 1910.1200). This material is classified as hazardous under Federal OSHA regulation. 4. FIRST AID MEASURES Inhalation: If inhaled, remove victim to fresh air. Skin: In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Get 134 Bommasandra medical attention if irritation persists. Wash clothing before reuse. Thoroughly clean shoes before reuse. Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Ingestion: If swallowed, DO NOT induce vomiting. Get medical attention immediately. Call a Poison Control Center. If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person. 5. FIRE-FIGHTING MEASURES Flash point 54 °F (12 °C) (closed cup)(Method: Standard : ASTM D 3828 - IP 303 (Seta Flash)) Auto-ignition temperature: 975 °F (524 °C) Lower flammable limit (LFL): 3 %(V) Upper flammable limit (UFL): 17 %(V) Extinguishing media (suitable): Water spray, Foam, Dry chemical, Carbon dioxide (CO2) Extinguishing media (unsuitable): High volume water jet Protective equipment: Material Safety Data Sheet ETHYLDIISOPROPYLAMINE (EDIPA) Product code: 001546 Version 1.0 Issued on: 07/27/2011 Page: 3 / 9 Fire fighters and others who may be exposed to products of combustion should wear full fire fighting turn out gear (full Bunker Gear) and self-contained breathing apparatus (pressure demand / NIOSH approved or equivalent). 135 Bommasandra Further firefighting advice: Fire fighting equipment should be thoroughly decontaminated after use. Cool closed containers exposed to fire with water spray. Do not permit water to enter containers. Do not use a solid water stream as it may scatter and spread fire. Fire and explosion hazards: When burned, the following hazardous products of combustion can occur: Nitriles Cyanides 6. ACCIDENTAL RELEASE MEASURES In case of spill or leak: Prevent further leakage or spillage if you can do so without risk. Evacuate area of all unnecessary personnel. Ventilate the area. Eliminate all ignition sources. Avoid generation of vapors. Contain and collect spillage with noncombustible absorbent material such as sodium bicarbonate, sodium carbonate, calcium carbonate, clean sand or non-acidic clay. Sweep or scoop up using non-sparking tools and place into suitable properly labeled containers for prompt disposal. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Consult a regulatory specialist to determine appropriate state or local reporting requirements, for assistance in waste characterization and/or hazardous waste disposal and other requirements listed in pertinent environmental permits. 7. HANDLING AND STORAGE 136 Bommasandra Handling General information on handling: Keep away from heat, sparks and flames. Do not taste or swallow. Avoid contact with the skin, eyes and clothing. Keep container closed. Check that all equipment is properly grounded and installed to satisfy electrical classification requirements. Use only with adequate ventilation. Wash thoroughly after handling. Container hazardous when empty. Emptied container retains vapor and product residue. Follow label warnings even after container is emptied. RESIDUAL VAPORS MAY EXPLODE ON IGNITION. DO NOT CUT, DRILL, GRIND, OR WELD ON OR NEAR THIS CONTAINER. Improper disposal or reuse of this container may be dangerous and/or illegal. Storage General information on storage conditions: Store in well ventilated area away from heat and sources of ignition such as flame, sparks and static electricity. Ensure that all storage and handling equipment is properly grounded and installed to satisfy electrical classification requirements. Static electricity may accumulate when transferring material. All metal and groundable storage containers, including but not limited to drums, cylinders, Returnable Intermodal Bulk Containers (RIBCs) and Class Material Safety Data Sheet ETHYLDIISOPROPYLAMINE (EDIPA) Product code: 001546 137 Bommasandra Version 1.0 Issued on: 07/27/2011 Page: 4 / 9 C Flexible Intermodal Bulk Containers (FIBCs) must be bonded and grounded during filling and emptying operations. Keep container tightly closed. Observe all federal, state and local regulations and National Fire Protection Association (NFPA) Codes which pertain to the specific local conditions of storage and use, including OSHA 29 CFR 1910.106 and NFPA 30, 70, 77, and 497. Store protected from moisture. Storage incompatibility – General: Store separate from: Oxidizers. Nitrates Peroxides Nitrous acid - Nitrites - Oxygen Strong acids Water Halogens Product likely to react violently in alkaline environment Temperature tolerance – Do not store above: 122 °F (50 °C) 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Airborne Exposure Guidelines: Engineering controls: Investigate engineering techniques to reduce exposures below airborne exposure limits or to otherwise reduce exposures. Provide ventilation if necessary to minimize exposures or to control exposure levels to below airborne exposure limits (if applicable see above).If practical, use local mechanical exhaust ventilation at sources of air contamination such as open process equipment. 138 Bommasandra Consult ACGIH ventilation manual or NFPA Standard 91 for design of exhaust systems. Respiratory protection: Avoid breathing vapor or mist. Where airborne exposure is likely or airborne exposure limits are exceeded (if applicable, see above), use NIOSH approved respiratory protection equipment appropriate to the material and/or its components. Full facepiece equipment is recommended and, if used, replaces need for face shield and/or chemical goggles. Consult respirator manufacturer to determine appropriate type equipment for a given application. Observe respirator use limitations specified by NIOSH or the manufacturer. For emergency and other conditions where there may be a potential for significant exposure or where exposure limit may be significantly exceeded, use an approved full face positive- pressure, self-contained breathing apparatus or positive-pressure airline with auxiliary self-contained air supply. Respiratory protection programs must comply with 29 CFR § 1910.134. Skin protection: Wear appropriate chemical resistant protective clothing and chemical resistant gloves to prevent skin contact. Consult glove manufacturer to determine appropriate type glove material for given application. Wear face shield and chemical resistant clothing such as a rubber apron when splashing may occur. Rinse immediately if skin is contaminated. Wash contaminated clothing and clean protective equipment before reuse. Wash thoroughly after handling. Material Safety Data Sheet 139 Bommasandra ETHYLDIISOPROPYLAMINE (EDIPA) Product code: 001546 Version 1.0 Issued on: 07/27/2011 Page: 5 / 9 Eye protection: Where there is potential for eye contact, wear chemical goggles and have eye flushing equipment immediately available. 9. PHYSICAL AND CHEMICAL PROPERTIES Color: colourless, light yellow Physical state: liquid Odor: strong, Amines pH: alkaline Density: 755.6 kg/m3 (68 °F (20 °C)) Specific Gravity (Relative density): 0.75 (72 °F( 22 °C)) Vapor pressure: 12 mmHg (77 °F (25 °C)) Vapor density: not determined Boiling point/boiling range: 259 - 262 °F (126 - 128 °C) Melting point: -49 °F (-45 °C) Solubility in water: 3.6 g/l Solubility in other solvents: [qualitative and quantative] Soluble in: Ethanol Isopropanol 10. STABILITY AND REACTIVITY Stability: 140 Bommasandra This material is chemically stable under normal and anticipated storage, handling and processing conditions. Materials to avoid: Very exothermic reaction and possibility of spattering with: Strong acids Halogens • Violent reaction and flammability with : Peroxides, Nitrates, Oxidizers. Product likely to react violently in alkaline environment • Very exothermic reaction with : Water • Formation of toxic products (n-nitrosamines) with: Nitrous acid and other nitrosating agents, Nitrites, Oxygen Corrosion with : light metals and alloys Material Safety Data Sheet ETHYLDIISOPROPYLAMINE (EDIPA) Product code: 001546 Version 1.0 Issued on: 07/27/2011 Page: 6 / 9 Conditions / hazards to avoid: Avoid moisture. Protect from heat. Hazardous decomposition products: Thermal decomposition giving toxic and corrosive products : Ammonia Carbon oxides 11. TOXICOLOGICAL INFORMATION Data on this material and/or its components are summarized below. Data for ETHYLDIISOPROPYLAMINE (EDIPA) Acute toxicity Oral: Slightly to moderately toxic. (rat) LD50 200 - 2,000 mg/kg. Skin Irritation: 141 Bommasandra Slightly irritating. (rabbit) Irritation Index: 2.0/8.0. (4 h) Eye Irritation: Severely irritating. (Alkaline product.) Skin Sensitization: Not a skin sensitizer. Guinea pig maximization test. (guinea pig) No skin allergy was observed Genotoxicity Assessment in Vitro: No genetic changes were observed in a laboratory test using: bacteria 12. ECOLOGICAL INFORMATION Chemical Fate and Pathway Data on this material and/or its components are summarized below. Data for ETHYLDIISOPROPYLAMINE (EDIPA) Biodegradation: Not readily biodegradable. (28 d) biodegradation 2 % Octanol Water Partition Coefficient: log Pow 2.35 Ecotoxicology Data on this material and/or its components are summarized below. Data for ETHYLDIISOPROPYLAMINE (EDIPA) Material Safety Data Sheet ETHYLDIISOPROPYLAMINE (EDIPA) Product code: 001546 Version 1.0 Issued on: 07/27/2011 Page: 7 / 9 Aquatic invertebrates: Slightly toxic. Daphnia magna (Water flea) 48 h EC(I)50 28.1 mg/l Algae: 142 Bommasandra Practically nontoxic. Pseudokirchneriella subcapitata (green algae) 72 h ErC50 = 150 mg/l Slightly toxic. Pseudokirchneriella subcapitata (green algae) 72 h EbC50 71 mg/l Microorganisms: Activated sludge 3 h EC50 912 mg/l 13. DISPOSAL CONSIDERATIONS Waste disposal: Disposal via incineration is recommended. Dispose of in accordance with federal, state and local regulations. Consult a regulatory specialist to determine appropriate state or local reporting requirements, for assistance in waste characterization and/or hazardous waste disposal and other requirements listed in pertinent environmental permits. Note: Chemical additions to, processing of, or otherwise altering this material may make this waste management information incomplete, inaccurate, or otherwise inappropriate. Furthermore, state and local waste disposal requirements may be more restrictive or otherwise different from federal laws and regulations. 14. TRANSPORT INFORMATION US Department of Transportation (DOT) UN Number : 1992 Proper shipping name : Flammable liquid, toxic, n.o.s. Technical name : (Ethyldiisopropylamine) Class : 3 Subsidiary hazard class : (6.1) Packaging group : II Marine pollutant : no International Maritime Dangerous Goods Code (IMDG) UN Number : 1992 143 Bommasandra Proper shipping name : FLAMMABLE LIQUID, TOXIC, N.O.S. Technical name : (ETHYLDIISOPROPYLAMINE) Class : 3 Subsidiary hazard class : (6.1) Packaging group : II Marine pollutant : no Flash point : 54 °F (12 °C) closed cup 15. REGULATORY INFORMATION Chemical Inventory Status EU. EINECS EINECS Conforms to US. Toxic Substances Control Act TSCA The components of this product are all on the TSCA Inventory. Material Safety Data Sheet ETHYLDIISOPROPYLAMINE (EDIPA) Product code: 001546 Version 1.0 Issued on: 07/27/2011 Page: 8 / 9 Australia. Industrial Chemical (Notification and Assessment) Act AICS Conforms to Canada. Canadian Environmental Protection Act (CEPA). Domestic Substances List (DSL). (Can. Gaz. Part II, Vol. 144) DSL All components of this product are on the Canadian DSL list. Japan. Kashin-Hou Law List ENCS (JP) Conforms to Korea. Existing Chemicals Inventory (KECI) KECI (KR) Conforms to Philippines. The Toxic Substances and Hazardous and Nuclear Waste Control Act 144 Bommasandra PICCS (PH) Does not conform China. Inventory of Existing Chemical Substances IECSC (CN) Conforms to New Zealand. Inventory of Chemicals (NZIoC), as published by ERMA New Zealand NZIOC Does not conform United States – Federal Regulations SARA Title III – Section 302 Extremely Hazardous Chemicals: The components in this product are either not SARA Section 302 regulated or regulated but present in negligible concentrations. SARA Title III - Section 311/312 Hazard Categories: Acute Health Hazard, Fire Hazard SARA Title III – Section 313 Toxic Chemicals: SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313. Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) - Reportable Quantity (RQ): The components in this product are either not CERCLA regulated, regulated but present in negligible concentrations, or regulated with no assigned reportable quantity. OSHA Regulated Carcinogens (NTP, IARC, OSHA Listed): NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. 145 Bommasandra IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA. United States – State Regulations Material Safety Data Sheet ETHYLDIISOPROPYLAMINE (EDIPA) Product code: 001546 Version 1.0 Issued on: 07/27/2011 Page: 9 / 9 New Jersey Right to Know No components are subject to the New Jersey Right to Know Act. Pennsylvania Right to Know Chemical Name CAS-No. 2-Propanamine, N-ethyl-N-(1-methylethyl)- 7087-68-5 California Prop. 65 WARNING! This product contains a chemical known to the State of California to cause cancer. Chemical Name CAS-No. Acetaldehyde 75-07-0 16. OTHER INFORMATION Miscellaneous: Other information: Refer to National Fire Protection Association (NFPA) Codes 30, 70, 77, and 497 and OSHA 29 CFR 1910.106, for safe handling. Latest Revision(s): Revised Section(s): Initial entry 146 Bommasandra Reference number: 000000031870 Date of Revision: 07/27/2011 Date Printed: 07/27/2011 Arkema Inc. believes that the information and recommendations contained herein (including data and statements) are accurate as of the date hereof. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY, OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED HEREIN. The information provided herein relates only to the specific product designated and may not be valid where such product is used in combination with any other materials or in any process. Further, since the conditions and methods of use are beyond the control of Arkema Inc., Arkema Inc. expressly disclaims any and all liability as to any results obtained or arising from any use of the product or reliance on such information. Material Safety Data Sheet Tetrahydrofuran, 99.5+%, for spectroscopy. ACC# 23011 Section 1 - Chemical Product and Company Identification MSDS Name: Tetrahydrofuran, 99.5+%, for spectroscopy. Catalog Numbers: AC222160000, AC222160010, AC222162500, AC222165000, AC268290000, AC268290010, AC268290025, AC268290040, AC268295000, AC610100040, AC610450010, AC610451000, AC610921000, BP1140-1, BP11401LC, NC9058040, NC9234867, NC9326115, T397RS-200ASME, T400RS-50, T421-1, T421RS-19, T421RS19, T421RS50, T422-1, T422RS-200, T422RS-50, T422RS200, T424-4, T425-1, T425-4, 147 Bommasandra T425N219, T425RS-115, T425RS-28, T425RS-50, T425RS115, T425RS19, T425SK-1, T425SK-4, T425SS-115, T425SS-19, T425SS-200, T425SS-50, T427-1, T427-4, T427POP200, T427RS-200, T427RS115, T427RS200, T427RS28, T427SK-4, T427SS115, T427SS19, T427SS200, T427SS28, T427SS50 Synonyms: Diethylene oxide; 1,4-Epoxybutane; Tetramethylene oxide; THF; Oxacyclopentane. Company Identification: Fisher Scientific 1 Reagent Lane Fair Lawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 Section 2 - Composition, Information on Ingredients CAS# Chemical Name Percent EINECS/ELINCS 109-99-9 Tetrahydrofuran 99.5+ 203-726-8 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: colorless liquid. Flash Point: -14 deg C. Danger! Highly flammable. Causes eye and respiratory tract irritation. May form explosive peroxides. Hygroscopic (absorbs moisture from the air). Target Organs: Kidneys, central nervous system, liver, respiratory system, eyes, skin. Potential Health Effects Eye: Contact with eyes may cause severe irritation, and possible eye burns. Vapors may cause eye irritation. Damage may be permanent. Skin: Causes skin irritation. May be absorbed through the skin. If absorbed, causes symptoms similar to those of inhalation. THF is not a skin sensitizer in animals. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression. Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Vapors may cause dizziness or suffocation. Inhalation may cause coughing, difficulty breathing and loss of consciousness. Causes irritation of the mucous membrane and upper respiratory tract. 148 Bommasandra Inhalation of tetrahydrofuran vapors may cause abnormal liver function as detected by laboratory tests. (Dupont) Chronic: Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. May cause liver and kidney damage. May cause lung damage. Narcotic in high concentrations. Data show carcinogenic activity in the liver and kidneys of laboratory animals. The kidney tumors were by a mechanism that has no relevance in humans. Section 4 - First Aid Measures Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get medical aid immediately. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Persons with skin problems or liver, kidney, lung, or blood diseases may be at increased risk from exposure to this substance. Section 5 - Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Forms peroxides of unknown stability. Extremely flammable liquid and vapor. Vapor may cause flash fire. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas. Extinguishing Media: Water may be ineffective. In case of fire, use carbon dioxide, dry chemical powder or appropriate foam. Flash Point: -14 deg C ( 6.80 deg F) Autoignition Temperature: 321 deg C ( 609.80 deg F) Explosion Limits, Lower:2.0 vol % Upper: 11.8 vol % NFPA Rating: (estimated) Health: 2; Flammability: 3; Instability: 1 Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. 149 Bommasandra Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Use water spray to dilute spill to a non-flammable mixture. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Use a spark-proof tool. Isolate area and deny entry. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Section 7 - Handling and Storage Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Take precautionary measures against static discharges. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame. Avoid breathing vapor or mist. Do not get in eyes. Avoid contact with skin and clothing. Storage: Keep away from heat, sparks, and flame. Store in a cool place in the original container and protect from sunlight. Keep under a nitrogen blanket. Keep from contact with oxidizing materials. Flammables-area. Store protected from moisture. Containers should be dated when opened and tested periodically for the presence of peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals. All peroxidizable substances should be stored away from heat and light and be protected from ignition sources. Section 8 - Exposure Controls, Personal Protection Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Exposure Limits Chemical Name ACGIH NIOSH OSHA - Final PELs 50 ppm TWA; 100 ppm STEL; Skin - potential 200 ppm TWA; 590 200 ppm TWA; 590 Tetrahydrofuran significant contribution mg/m3 TWA 2000 ppm mg/m3 TWA to overall exposure by IDLH the cutaneous r oute OSHA Vacated PELs: Tetrahydrofuran: 200 ppm TWA; 590 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard 150 Bommasandra EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - Physical and Chemical Properties Physical State: liquid Appearance: colorless Odor: ether-like pH: ~7 (in aq soln) Vapor Pressure: 145 mm Hg @ 20 deg C Vapor Density: 2.5 (air = 1) Evaporation Rate:>1 (Butyl Acetate = 1) Viscosity: 0.48 cP @ 20C Boiling Point: 66 deg C Freezing/Melting Point:-108.5 deg C Decomposition Temperature:Not available. Solubility: Soluble. Specific Gravity/Density:0.89 Molecular Formula:C4H8O Molecular Weight:72.10 Section 10 - Stability and Reactivity Chemical Stability: Under normal storage conditions, peroxidizable compounds can form and accumulate peroxides which may explode when subjected to heat or shock. This material is most hazardous when peroxide levels are concentrated by distillation or evaporation. THF should never be distilled to dryness. Conditions to Avoid: Light, ignition sources, moisture, excess heat, evaporating to near dryness, confined spaces. Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, oxygen, bromine, metal halides, lithium tetrahydroaluminate, borane, sodium aluminum hydride, sodium tetrahydroaluminate, caustic alkalis. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. Hazardous Polymerization: May occur. Section 11 - Toxicological Information 151 Bommasandra RTECS#: CAS# 109-99-9: LU5950000 LD50/LC50: CAS# 109-99-9: Inhalation, rat: LC50 = 21000 ppm/3H; Oral, rat: LD50 = 1650 mg/kg; . Carcinogenicity: CAS# 109-99-9: ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans California: Not listed. NTP: Not listed. IARC: Not listed. Epidemiology: No information found Teratogenicity: Animal data show developmental effects only at exposure levels producing other toxic effects in the adult animal. Reproductive Effects: Animal testing for reproductive effects shows no change in reproductive performance. Mutagenicity: THF has not produced genetic damage in mammalian cell cultures or in animals. It has not been tested for its ability to cause permanent genetic damage in reproductive cells of mammals (not tested for heritable genetic damage). Neurotoxicity: No information found Other Studies: Section 12 - Ecological Information Ecotoxicity: Fish: Fathead Minnow: LC50 = 2160 mg/L; 96 Hr; Flow through bioassay (pH 7.5)Water flea Daphnia: EC50 =5930 mg/L; 24 Hr; Tetrahydrofuran is not expected to adsorb to suspended matter in the water based on its measured Koc values. This compound should volatilize from water surfaces. An estimated BCF value of 1 suggests that tetrahydrofuran will not bioconcentrate in aquatic organisms. Environmental: If released to the atmosphere, tetrahydrofuran will exist solely in the vapor phase and is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and nitrate radicals with half-lives of about 1 and 3 days, respectively. Measured Koc values of 23 and 18 indicate that tetrahydrofuran will have very high mobility in soil. Physical: No information available. Other: Do not empty into drains. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a 152 Bommasandra hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: CAS# 109-99-9: waste number U213 (Ignitable waste). Section 14 - Transport Information US DOT Canada TDG Shipping Name: TETRAHYDROFURAN TETRAHYDROFURAN Hazard Class: 3 3 UN Number: UN2056 UN2056 Packing Group: II II Additional Info: FLASHPOINT -21 C Section 15 - Regulatory Information US FEDERAL TSCA CAS# 109-99-9 is listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules CAS# 109-99-9: 40 CFR 799.5000; 40 CFR 799.5115 Section 12b CAS# 109-99-9: Section 4, 1 % de minimus concentration TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ SARA Section 302 Extremely Hazardous Substances None of the chemicals in this product have a TPQ. SARA Codes CAS # 109-99-9: immediate, fire, reactive. Section 313 No chemicals are reportable under Section 313. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: 153 Bommasandra None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# 109-99-9 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts. California Prop 65 California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI F Risk Phrases: R 11 Highly flammable. R 19 May form explosive peroxides. R 36/37 Irritating to eyes and respiratory system. Safety Phrases: S 16 Keep away from sources of ignition - No smoking. S 29 Do not empty into drains. S 33 Take precautionary measures against static discharges. WGK (Water Danger/Protection) CAS# 109-99-9: 1 Canada - DSL/NDSL CAS# 109-99-9 is listed on Canada's DSL List. Canada - WHMIS This product has a WHMIS classification of B2, D2B. This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations. Canadian Ingredient Disclosure List CAS# 109-99-9 is listed on the Canadian Ingredient Disclosure List. Section 16 - Additional Information MSDS Creation Date: 7/15/1999 Revision #9 Date: 6/29/2007 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages. 154 Bommasandra Off-site Emergency 155 Bommasandra 1.1.1 Off-site Emergency If the accident is such that it affects inside the factory are uncontrollable and it may spread outside the factory premises, it is called as Off-site Emergency. Assessment reveals that an Off-site emergency is a very remote possibility in our factory. If there is a situation, first we shall avail the service of local police to warn and advice the local public about things to do to save them from the effect of emergency situation. Moreover, the factory is located in industrial area. Hence, there are no residential houses in factory surrounding area. 1.2 Offsite Emergency Plan 1.2.1 Preamble An offsite emergency arising out of chemical hazards in one, which has potential to cause serious damage or loss of life beyond the plant boundary. In addition, Accidents during transportation of hazardous chemicals by road, rail, pipeline etc. can cause offsite emergencies. Emergency services such as Police, Fire, Medical etc., need to be prepared to handle such situations promptly and effectively. It is mandatory under Rule 16 of the Hazardous Chemical Rules for District authorities to prepare an off-site emergency plan in respect of clusters of hazardous chemical industries or at locations where accidents are likely to have an off-site adverse effect. In order to be in a state of preparedness to respond to the accidents and minimize their adverse impacts on the offsite population, requires an offsite emergency plan to be prepared by the District Controller for every District or Industrial Areas as applicable. 1.2.2 Objective The objective of the present assignment is to prepare an area specific Offsite Emergency Action Plan for Jigani, Bangalore, Karnataka which can be practically implemented / activated at a short notice to ensure minimal impact on life and property due to emergencies arising out of Chemical Accidents or during Transportation of Hazardous Chemicals in the district. 156 Bommasandra The plan should be regularly updated when there are changes occurring in the Industrial set up, Transportation Aspects, Key Manpower and Administrative Changes etc., Regular drills, Training of key persons, increasing safety awareness etc is extremely important areas that must be looked into for sound preparedness. 1.2.3 Offsite Emergency Control As we all know that jigani is an industrial area having many industries of large, medium & small scale. After the “Bhopal Gas Tragedy” (Methyl Isocyanides- MIC Poisonous and toxic gas release Accident at Union Carbide, 1984) the Government felt an immediate need to be more conscious about handling of Hazardous Chemicals. Central control room Centre or Offsite Industrial Emergency Control Room “OIECR” should be established by company. It should work under the Governing Council. The Governing Council should be headed under the chairmanship by District Collector & Magistrate of jigani. The Governing Council Members are the permanent Ex. Officio Members to manage the affairs of the Emergency Control Room. 1.2.4 Emergency Instruction to the General Public The Notification of Emergency The emergency can be declared by following media to alert or alarm the public ; 1. Public address system 2. Blow horns/Bells 3. Sirens / Hooters 4. Telephone message / Fax Messages / Hot lines/ Pager / E-mail / Mobile Phone / Satellite system 5. Sending messages through a messenger 6. Rushing personally to the Central Control Room or to the nearest Police Department or Fire Department for declaration of emergency. 7. Raising of Flag for denoting the level of natural calamities 8. Ham Radio 9. By any other source by which information can reach to the public in time. 157 Bommasandra 1.2.5 Category of Alarm Systems The following alarm system may be considered which will identify the various level of emergency. 1.2.5.1 First Level Warning (Fire Alarm) For an accident / incident within the unit Hooter / Siren – Short, intermittent 1.2.5.2 Second Level Warning When the District Authority receives information that a toxic or flammable gas has leaked then the siren has to be sounded in order to facilitate early evacuations from the unit. Siren – A wailing short and long intermittent siren notification of emergency. 1.2.5.3 Third Level Warning (All Clear) When the District Authority considers that the accident / incident is under control, emergency is withdrawing and it is safe for re-entry. Siren – A wailing, long and continues, intermittent siren. 1.2.6 Fire Fighting System In order to tackle great risk of fire explosion, spillage of hazardous liquid or release of toxic gases, firefighting system should be mobilized under chief fire officer. The operational response will be coordinated from the Central Control Room. 1.2.7 General Instruction to the Public A major emergency may affect areas outside the works. The surrounding public will be alerted with public address system by Police or Government Authorities or nearby industrial concerns. The siren / hooter will blow to indicate arising the emergency situation. It will be indicated which kind of emergency arised, Start the Radio / TV for further instruction & act accordingly. So that public will take prompt action to protect them-selves or rush to the safe shelter as instructed by the authority. 158 Bommasandra First of all to ascertain which type of emergency arised. 1. Fire 2. Explosion 3. Gas Leakage / Release 4. Collapse of Building, Brusting of Vessel etc. 5. Natural Calamities. If gas leakage emergency arised, ascertain probability of gas whether flammable, toxic or poisonous. The following actions are suggested as per prevailing situation: Otherwise follow the instruction as issued by the authority 1.2.7.1 Flammable Gas : a. Be calm, don’t get panicky b. Do not light Bidi / Cigarette / Lighter etc c. Shut down open flame, gas and electrical instruments or any source of ignition d. Do not move any vehicle in the area e. Do not go near the incident & don’t allow any others f. Shut down the windows, doors etc. & seat open ground or terrace. g. Follow the instruction as directed by the authority 1.2.7.2 Toxic Poisonous Gas a. Cover your nose with wet hand kerchief / cloth and breath through it. b. Come out in open, check the wind direction and move away quickly in perpendicular direction of wind. (cross wind direction ) c. Immediately go & try to get to a higher elevation, if gas is heavier than air (like chlorine, as it settles in low lying area) Follow the instruction and reach safe shelter as instructed notified by Government Authority or Public authority. 1.2.7.3 General Instruction : (A) DON’T 1. Do not get panicky, be calm 159 Bommasandra 2. Do not approach the site of incident as a spectator 3. Do not approach unnecessarily for information or more enquires 4. Do not allow unnecessarily crowd nearby incident place 5. Do not believe in rumors unnecessarily (B) DO’S 1. Listen radio, TV or Public Addressing System. 2. Emergency will be communicated by public addressing system / TV / Radio or siren (Siren- code wailing sound for one minute) 3. Follow the instruction & convey to others accordingly 4. On announcement of withdrawal of emergency or clearance Siren, start your routine work 5. On enquiry, deposit your statement as required by authority at the time of investigating the incident 6. Co-operate, help and assist the person(s) / authority handling the emergency and rescue operation. Table 0-1 Emergency Telephone Numbers Sr. Designation / Post STD Telephone Number No. Code Office Resident Mobile A. Control Rooms 1 NDMA, Karnataka 080 22032416/1 - - 070 2 Fire Service Station, Bangalore 080 29442999/2 - - 251780 3 Police Control Room, Bangalore 080 2294222 - - 4 Civil Defence Control Room, Karnataka 080 25570733/2 - - 2971501 5 Railway Control Room 080 22942666 - 9480802140 6 Airport Authority, Bangalore 080 25223344 - - 7 Home Guard, Bangalore 080 23142542 - - 8 Emergency Centre-Nearby Hospital - 102 - - B .Collectoralay-Jigani 1 The Deputy Commissioner, Bangalore 080 22211292/2 - - Urban District 2214553 2 Special Deputy Commissioner 080 22214370 - - 160 Bommasandra 3 Dist. Supply Officer 080 22215594 - - 4 Dist. Planning Officer (D.P.O.) 080 22253651 - - 1.2.8 Security & Police Security, protection of life & property and traffic control & maintenance of law and order should be taken care by police. During an emergency duties and responsibilities of the police may be: a) Cordoning of the incident area b) Warning public about the hazards c) Traffic Control d) Assist fire fighting services e) Assist first-aid medical teams f) Assist evacuation and ensure protection of property in evacuated areas. Different phases of emergency management practices would be as under: a) Before the Crisis Proper planning of manpower, transport and communication network to coordinate possible incident areas and regulation of traffic should be made for each industry in the area. b) During the Crisis The Security Commander of the area will set in motion the relevant contingency plan to control the operation. c) After the Crisis Protect property in the evacuated area. d) Media The Control Room should release an up-to-date information to the media to the people. Sr. Designation / Post STD Telephone Number No. Code Office Resident Mobile Police 1 Police Emergency Line - 100 - - 2 Police Commissioner, Bangalore 080 22260222/22 - 9480801001 942215 161 Bommasandra 3 Police Station – Jigani 080 27825108 - - 4 Superintendent of / Local Police 080 22942215/22 - - Bangalore 260707 5 Traffic Police Emergency Line - 103 - - 6 Jigani Police Station 080 27825108 - - 7 Bannerghatta Police Station 080 27828595 - - Fire 1 Fire Emergency Line - 101 - - 2 Fire Station – Electronic City 080 22971576 - - 3 Fire Brigade Number, Electronic City 080 22971576 - - 4 Fire Brigade Number, Bannerghatta Road 080 22971538 - - 5 KIADB Industrial. Estate 080 22265383 - - 6 Karnataka State Natural Disaster Monitoring 080 67355000 - - Centre 1.2.9 Medical facilities in case of emergency A large number of ambulances would be necessary to transport casualties to the casualty response centre and base hospital. For this purpose, jeeps/ matadors/ special wagons which can be converted as ambulance at short notice should be kept at the unit and the Control Room or should have the mutual aid agreement with nearby hospitals as mentioned in Error! Not a valid bookmark self-reference.. Table 0-2 Hospitals list in case of emergency Sr. Designation / Post STD Telephone Number No. Code Office Resident Mobile 1 Suhas General & Charitable Hospital 080 27826145/14 - - 4 2 Hospital Emergency Line - 102 - - 3 Suhas General & Charitable Hospital, 080 27826145/14 - - Jigani 4 4 St. John’s Ambulance Association 080 22223384 - - 5 Factory OHC 080110 415531 - - 162 Bommasandra 6 All India Emergency Number - 108 - - Sr. Designation / Post STD Telephone Number No. Code Office Resident Mobile STATE GOVERNMENT OFFICERS 1 Karnataka State Pollution Control Board, 080 23221575 - 9945276544 Bangalore 2 Directorate of Factories and Boilers, 080 26531200 - 9448100590 Karnataka 3 Jt. Director, Industrial Safety & Health, 080 26531207 - 9880128763 Bangalore 4 Dy. Director, Industrial Safety & Health, 080 26531206 - 9448353099 Bangalore 5 Regional Officer (ESI), Bangalore 080 26742485 - - 6 Chief Engineer (PWD), Bangalore 080 22212830 - 9483008987 7 Transport Commissioner, Bangalore 080 22254900 - 9880726761 8 Commissioner of Agriculture, Karnataka 080 22212804 - 8277929803 Sr. Designation / Post STDCod Telephone Number No. e Office Resident Mobile Central Government 1 Chief Engineer CPWD, Karnataka 080 25534968 - - 2 Labour Enforcement Officer, Karnataka 080 22032313 - - News Paper 1 Indian Express 080 22866893 - 9448689473 2 Times of India 080 42200000/202 - - 1.2.10 Mutual Aid All the nearby industrial units which are mentioned in Table 0-3 should have mutual aid arrangement for getting/extending help in firefighting facilities, special firefighting agents, trained 163 Bommasandra manpower, etc. The Control Room will allocate additional resources to fire zone including protective equipments kept centrally as a pool. Table 0-3 List of industries nearby with phone numbers Sr,No. Name of Industry Address Phone No. 1 Mallik Engineering No 126, Road No 3, KIADB Indl 080 - 27825436, Estate, II Phase, Jigani,AnekalTaluk, Bangalore 560 105 2 Shashi Bio-energy Products No.104, KIADB Industrial Area, 080-23202370, Jigani, Bangalore - 560105, Near 9620166777 APC 3 J’Pan Tubular Components FLAT NO 115, Industrial Estate +917829916937 Jigani, Bommasandra, Fort Road, Bengaluru - 562106, Karnataka 4 Aron Universal Ltd. # 25/1,2nd Phase, Jigani Industrial 91 80 27825331/ Area, Jigani, Bangalore (South) – +91 80 27825315 560105, Karnataka 5 Hikal Ltd. #82/A, KIADB Industrial Area 080 – 2782 6800 Jigani, Bangalore – 560 105 6 OTIS No.92, KIADB Indl.Estate, Phase 080 - 40314500 II, JiganiIndl.Area, AnekalTaluk,Bangalore - 562106. 7 Kirloskar Toyota textile machinery Pvt. Plot 10 ~ 13, Phase II 08110-419555 Ltd. Jigani Industrial Area, Jigani, Bangalore 560 105. Karanatka 8 Bill Forge Pvt Ltd No.98-L, Kiadb Industrial Area, 080-27826993 2nd Phase, Jigani Industrial Area, Bangalore - 562106 9 Kumar Organics Pvt. Ltd. #36, KIADB Industrial Area 080 – 2782 5439, Jigani, Bangalore – 560 105 080 – 2782 5376 10 Micropack Plot No.16, AnekalTaluk, Jigani 080-27825223 Industrial Area, Bangalore - 562106, Near APC Circle (Map) 11 HCL Technologies No. 129, JiganiBommasandra, 080-678 10000 Link Road, Jigani Industrial Area, Bengaluru, Karnataka 562106 12 Microbabs #121, KIADD, AnekalTaluk, Jigin 080-27839036 Link Road, Bommasandra Industrial Area, Bangalore - 560099 13 RichcoreLifesciencesPvt Ltd Plot No. 204 and 237, 081104 19777 Bommasandra - Jigani Link Road, K.I.A.D.B Industrial Area, Bengaluru, Karnataka 560105 14 BIOCON BIOCON SEZ, Biocon Park 080-28083912 Plot# 2&3 Bommsandra Iv Phase, Jigani Link Road, BommasandraIndl Area Bangalore, Karnataka Pin :560099 164 Bommasandra 15 Strides Shasun Limited Strides House, Opposite IIM-B, 080-678 40000 Bannerghatta Main Road, Bilekahalli, Bengaluru, Karnataka 560076 16 ApotexPharmachem Site No. 1A, 4th Phase, 080 2289 1000 BommasandraJigani Link Road, Bommasandra Industrial Area, Bengaluru, Karnataka 560099 17 Sigma Aldrich Plot No. 12, Bommasandhara, 91-80- Jigani Link Road, Bengaluru - 66219443/6621940 560100, Karnataka, India 0/66219000 18 Anthem Bioscience Pvt Ltd No 49, Canara Bank Road, 080 4044 4000 Bommasandra Industrial Area,Phase 1,Hosur Road, Bengaluru, Karnataka 560099 19 Ansell No - 74 - 91, KIADB Industrial 080-27826223 Area, Jigani 2nd Phase, Anekal, Bangalore-562106 20 Sansera Engineering Pvt Ltd Bommasandra Industrial Area, 080 2783 3056 Bommasandra, Karnataka 560099 165