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Expression Level of TGF-Β1, U-Ⅱ in Patients with Bronchial Asthma

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Expression Level of TGF-Β1, U-Ⅱ in Patients with Bronchial Asthma Journal of Hainan Medical University (2015)44-45 44 Journal of Hainan Medical University http://www.apjtm.net/JHMU/index.htm Expression level of TGF- 1, U- in patients with bronchial asthma 毬 栻 1 2 2 2 2 Shang-Sun Cai , Guo-Ping Wu *, Yuan-Zheng Yang , Ping Rao , Guang-Yu Wang , Qiong- Lian Huang2 1Center Health Hospital of Changliu, Haikou 570312, China 2Affiliated Hospital of Hainan Medical University, Haikou 570102, China ARTICLE INFO ABSTRACT To investigate the expression level in the serum of patients with bronchial asthma in Article history: Objective: Received TGF- 1, U- and their correlation. Methods: U- was measured by radioimmunoassay and 栻 栻 Received in revised form TGF-毬1 was measured by double antibody sandwich ELISA method in 45 patients with acute Accepted 毬 Available online bronchial asthma, 43 cases of bronchial asthma in remission period and 41 healthy subjects. The correlation between TGF- 1 and U- was also analyzed. Results: There were significant 栻 Keywords: differences in TGF- 1 and U-毬 between healthy subjects and bronchial asthma patients 毬 栻 Bronchial asthma (P<0.01), and the differences between patients at acute stage and remission stage was also TGF- 1 significant (P<0.01). TGF- 1 was positively correlated with U- (P<0.05). Conclusions: U-Ⅱ 毬 栻 TGF- 1 and U- are important毬 indicators for treatment of bronchial asthma. 毬 栻 1. Introduction the standard of diagnosis and treatment guideline[2]. Subjects complicated with severe diseases such as diseases of heart, liver, Bronchial asthma is a common disease of respiratory system. It kidney or hematopoietic system; during pregnancy or breastfeeding is characterized as recurrent paroxysmal asthma, dyspnea, chest period, or with immune stimulant or systematic treatment were distress or cough etc. Recently, the morbidity and mortality of excluded. There were three groups: acute bronchial asthma group, bronchial asthma are increasing. It is reported that the incidence including 27 males and 18 females, aged 37-79 years old, with of adult bronchial asthma is 1.2%-25.5%[1]. At present, imbalance of cytokine excreted by Th1/Th2 cell is regarded as the important average age as (48.2±6.5) years old; bronchial asthma during pathogenesis. Transforming growth factor- 1 (TGF- 1) is a remission period group, including 24 males and 19 females, aged multifunction regulatory cytokine, and plays 毬an important毬 role in 36-80 years old, with average age as (47.5±7.1) years old; and immune regulation, cell growth, cell differentiation, synthesis and control group, including 22 males and 19 females, aged 38-82 years preservation of extracellular matrix. Urotensin- (U- ) can shrink old, with average age as (49.3±7.5) years old. And there was no respiratory tract and pulmonary vessels, and promote栻 栻 proliferation significant difference in age or gender (P>0.05). All subjects signed of smooth muscle in airway and pulmonary artery. So far, no study the informed consent. on correlation between TGF- 1 and U- has been reported. We measured TGF- 1 and U- 毬 by ELISA栻 and radioimmunoassay, respectively to explore毬 the correlation栻 between them. 2.2. Treatment method ELISA for TGF- 1 and radioimmunoassay for U- were 2. Materials and methods 栻 provided by Yiding Biological毬 Agent Limited Company in Hainan. 2.1. Clinical data A total of 5 mL venous blood was extracted under fasting. The plasma was extracted by centrifuge, and preserved in refrigerator. All patients visiting from March 2009 to November 2014 met U- was measured by radioimmunoassay and TGF- 1 was 栻 measured by double antibody sandwich ELISA method according毬 *Corresponding author: Guo-Ping Wu, Chief Physician, Professor, Affiliated Hospital of Hainan Medical University, Haikou 570102, China. to the instruction. Tel: 13307591111 E-mail:[email protected] Shang-Sun Cai et al./ Journal of Hainan Medical University (2015)44-45 45 2.3. Statistical analysis pulmonary vessels contract, and can promote proliferation of smooth muscle of airway and pulmonary artery. We found that U- level of 栻 All data were expressed as mean±SD. They were analyzed by patients with bronchial asthma were significantly higher than that SPSS 15.0 and t test. The correlation was analyzed by Pearson of control group (P<0.01), and the level was significantly higher in analysis. The difference was considered as significant if P<0.05. acute period group (P<0.01), which is similar to some studies[12- 15]. U- may take part in airway remodeling, which need vessel 栻 contraction active substances and related regulatory factors. In our 3. Results study, it also shows that TGF- 1 is positively correlated with U- 毬 栻 (P<0.05), which is similar to study of Liang et al[16]. 3.1. TGF- 1 and U- levels 毬 栻 References There were significant differences in TGF- 1 and U- between 栻 healthy subjects and bronchial asthma patients毬 ( <0.01), and the P [1] Zhong NS. Basic and clinic study of bronchial asthma. Beijing: People differences between patients at acute stage and remission stage was Medical Publishing House; 2006, p. 14-910. also significant (P<0.01) (Table 1). [2] Asthma Group of Respiratory Medicine Branch of Chinese Medical Association. Guidance of prevention and treatment for bronchial asthma. Table 1 Chin J Tuberculosis Respiratory Dis 2008; 3(31): 177-185. TGF-毬1 and U-栻 levels (mean依SD). n [3] Heijink IH, Marcel Kies P, van Oosterhout AJ. Der p, IL-4, and TGF- Groups TGF-毬1 (ng/mL) U-栻 (pmol/L) beta cooperatively induce EGFR-dependent TARC expression in airway Acute stage 45 31.26依8.27 5.15依1.04 epithelium. Am J Respir Cell Mol Biol 2007; 36(3): 351-359. Remission stage 43 9.51依2.19*# 3.88依1.21*# [4] Leung SY, Niimi A, Noble A. Effect of transforming growth factor- Control group 41 3.46依0.83 2.32依0.34 beta receptor I kinase inhibitor 2, 4 disubstituted pteridine (SD-208) in P< *Compared with control group, 0.01; #Compared with acute stage, chronic allergicairway inflammation and remodeling. J Pharmacol Exp P< 0.01. Ther 2006; 319(2): 586-594. [5] Howell JE, McAnulty RJ. TGF-beta: its role in asthma and therapeutic 3.2. Correlation analysis potential. Curr Drug Targets 2006; 7(5): 547-565. [6] Xu MZ, Huang M, Jiang L. Relationship between TGF- 1 and 毬 Pearson analysis showed that TGF- 1 was positively correlated bronchial asthma. Inner Mongolia Med J 2005; 37: 101-102. 毬 with U- (P<0.05). [7] Zhao Y, Li YM, An CX. Effect of budesonide on airway TGF- 1 in 栻 毬 pulmonary tissue during remodeling and bronchial pulmonary alveolus douche. J Clin Pedi 2010; 28: 173-177. 4. Discussion [8] Ma X, Ding MJ, Han YL. TGF- 1 and leukotriene in asthma children. J 毬 Clin Pedi 2010; 28: 1152-1154. Lung is an organ with respiratory tract circulation and body [9] Liu WD, Lu JR. IL- 12, TGF- 1 and Ig E in asthma children. Chin J 毬 circulation. When asthma occurs, inflammatory cell, locally Contemporary Pedi 2008; 10: 146-148. infiltrated eosinophil fibroblast, airway epithelial cell, endothelial [10] Joseph J, Benedict S, Badrinath P. Elevation of plasma transforming cell and bronchial fibroblast in airway wall are expressed, which growth factor betal levels in stable nonatopic asthma. Ann Allergy Asthma participate in airway remodeling via various pathways. Many Immunol 2003; 91(5): 472-476. scholars believe that TGF- 1 has double regulation function. On [11] Hay DW, Luttmann MA, Douglas SA. Human urotensin- is a potent 栻 栻 one hand, it affects inflammatory cell to participate in initiation of spasmogen of primate airway smooth muscle. Br J Pharmacol 2000; inflammation and immune reaction of airway; on the other hand, it 131(1): 10-12. can promote proliferation of fibrocyte, then induce airway epithelium [12] Li JD, Yu ZH, Liu BY. Urotensin and adrenomedullin in asthma 栻 fibrosis, airway remodeling, increased airway responsiveness, patients. Chin J Tuberculosis Respiratory Dis 2003; 26(12): 797. thickened airway wall and decreased pulmonary function[3-5]. Many [13] Douglas SA, Behm DJ, Aiyar NV. Nonpeptidic urotensin receptor 栻 researchers have studied on the relationship between TGF- 1 and antagonist I: in vitro pharmscological characterization of SB2706375. Br 毬 asthma, and drew different conclusions. We found that TGF- 1 of J Pharmacol 2005; 145(5): 620-635. 毬 patients with bronchial asthma were significantly higher than that [14] Qi J, Du J, Tang X. The upregulation of endothelial nitric oxide synthase of control group (P<0.01), and the level was significantly higher and urotensi is associated with pulmonary hypertension and vascular 栻 in acute period group (P<0.01), which is consistent with studies of diseases in rats produced by aortocaval shunting. Heart Vessels 2004; Mao et al, Zhao et al and Ma et al[6-8]. Some studies show different 19(2): 81-88. results, indicating that the pathology may be related with other [15] Wu R, Chen YH, Yao WZ. Change of urotensi in induced sputum of 栻 factors. asthma patients. Chin J Resp Critical Care Med 2008; 7(2); 128-131. Reversible bronchospasm and high airway responsiveness are [16] Liang YF, Zhang H, Zhang WX. urotensi and TGF- 1 in asthma rats 栻 毬 main features of bronchial asthma. Till now, U- is the strongest with airway remodeling. Chin J Resp Critical Care Med 2008; 7(2): 128-131. 栻 vasoactive peptides[11,12]. It can make respiratory tract and .
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