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UPMC Cancer Centers and University of Pittsburgh Cancer Institute FALL 2008 FALL

A coordinated, personalized approach to care 08_CANCER_MAG_ck9_ProofRevisions:Clean copy 9/23/08 11:29 AM Page 2

CONTENTS

LIFTING A FINANCIAL BURDEN FOR PATIENTS UPMC Cancer Centers and Helping patients make ends meet University of Pittsburgh Cancer Institute 4

SIMPLIFYING THE COMPLEX WORLD OF CANCER A coordinated, personalized approach to care 8

FINDING THE LINK Research initiatives target hereditary cancers 12

EDUCATING THE ‘PLAIN’ COMMUNITY Outreach program brings cancer education to the Amish 16

THE POWER OF PARTNERSHIP Acknowledging those who financially support cancer research and care 20

NEWS BRIEFS

DISCOVERY & CARE 28 Cancer Discovery & Care is a publication of the University of Pittsburgh Cancer Institute (UPCI) and UPMC Cancer Centers and is produced by UPMC Marketing Communications. All rights reserved. No portion of this magazine may be reproduced without written permission. Send suggestions, comments, or address changes to Betsy Martinelli at UPCI/UPMC Cancer Centers, Office of Communications, UPMC Cancer Pavilion, 5150 Centre Ave., Room 457c, Pittsburgh, PA 15232, or via e-mail at [email protected]. 08_CANCER_MAG_ck9_ProofRevisions:Clean copy 9/23/08 11:29 AM Page 4

UNIVERSITY OF PITTSBURGH CANCER INSTITUTE UPMC CANCER CENTERS EXECUTIVE LEADERSHIP EXECUTIVE LEADERSHIP

Ronald B. Herberman, MD – Director Ronald B. Herberman, MD – Director PROVIDING A PERSONALIZED APPROACH TO CARE Hillman Professor of Oncology Stanley M. Marks, MD – Director of Clinical Services Associate Vice Chancellor, Cancer Research and Chief Medical Officer Navigating the complexities of our health care system is becoming David L. Bartlett, MD – Co-Director of Surgical Oncology Services and Chief, Division of Surgical Oncology increasingly challenging for patients. The New York Times recently lamented Jeffrey E. Shogan, MD – Director of Business Services the disparities in cancer care available to patients in a landmark article and Chief Business Officer Michael J. Becich, MD, PhD – Associate Director for Cancer Informatics highlighting the importance of a coordinated care approach to achieving Charles E. Bogosta, MBA – Executive Vice President, Cancer Services Dana Bovbjerg, PhD – Director, Biobehavioral Medicine Program good outcomes for patients. Charles E. Bogosta, MBA – Associate Director for Finance Peter D. Tate – Chief Financial Officer At UPMC Cancer Centers and the University of Pittsburgh Cancer Institute, the close collaboration Preet M. Chaudhary, MD, PhD – Director of Translational Research of medical, radiation, and surgical oncologists with the referring physician ensures that patients are David L. Bartlett, MD – Co-Director of Surgical Oncology Services and Co-Leader, Hematologic Malignancies Program and Chief, Division of Surgical Oncology being evaluated more quickly and entering treatment sooner — when the cancer is most treatable. Maryann Donovan, PhD, MPH – Associate Director Our multidisciplinary model of care is not only enhancing the patient experience, but also advancing Peter G. Ellis, MD – Director of Medical Oncology Network for Research Services and Advancement the science of cancer prevention, detection, and treatment, as the treatment team works closely Saldano Ferrone, MD, PhD – Associate Director Susan Frank, RN, MSN – Chief Nursing Officer, Interim with researchers to incorporate the latest clinical trials into each patient’s treatment strategy. for Faculty Career Development and Advancement

Dwight E. Heron, MD – Director of Radiation Oncology Services Dwight E. Heron, MD – Director of Radiation Oncology Services Our multidisciplinary model of care We understand that cancer treatment can take a significant toll on the patient is not only enhancing the patient and their family. That’s why we are committed to treating the whole person, Vijaya C. Gandhi, PhD, MBA – Associate Director Susan E. Hoolahan, RN, MSN, CNAA-BC – Interim Vice President experience, but also advancing the through ancillary services such as behavioral medicine, rehabilitation, social for Clinical Services for Administration and Strategic Planning science of cancer prevention, work, palliative care, nutrition, genetic counseling, and patient education, to Michael T. Lotze, MD – Associate Director for Strategic Partnerships James D. Luketich, MD – Co-Director of Surgical Oncology Services detection, and treatment provide a personalized approach to care from diagnosis through treatment. and Director and Chief, Heart, Lung, and Esophageal Surgical Institute Betsy S. Martinelli – Manager of Communications Our patient navigators and support staff work closely with each patient and their family to assist with Colleen McCabe Mantini, MPA – Director of Government Relations Betsy S. Martinelli – Manager of Communications coordinating appointments, referrals to support services, and identifying financial assistance options Courtney McCrimmon – Manager of Media Relations when necessary. Colleen McCabe Mantini, MPA – Director of Government Relations Jennifer M. Raetz – Development Director UPMC Cancer Centers has been designated a “Blue Distinction Center for Complex and Rare Jennifer M. Raetz – Development Director Shivendra V. Singh, PhD – Director of Basic Research Cancers” by the Blue Cross Blue Shield Association, due in part to the cutting-edge therapies and technologies being developed here in Pittsburgh. This distinction recognizes our strong commitment Peter D. Tate – Chief Financial Officer to superior and expert cancer care for every patient.

By streamlining the complexities of cancer care we are easing the burden of this devastating disease.

UPCI COUNCIL

Sy Holzer, Chair Chip Ganassi Kevin McClatchy Frederic B. Sargent Elsie H. Hillman, Vice Chair Edwin H. Gott Jr. Leslie Merrill McCombs Steve Schwarzwaelder Curtis Aiken Thomas B. Grealish Martin G. McGuinn Dan Shapira Thomas Balestrieri Roy W. Haley Katie McSorley Robert Slagle G. Nicholas Beckwith III Robert W. Hannan Bob Meyer Sandy Snyder James Broadhurst I. N. Rendall Harper Jr. Eugene J. O’Sullivan Lorene Steffes Harriet Crawford The Honorable Melissa A. Hart Arnold Palmer Janet B. Taber (honorary member) Barbara Crown Mark Hart Brian Patten Thomas VanKirk Joseph W. DeNardo Bill Isler Bradley Penrod The Honorable Jack Wagner Ronald B. Herberman, MD Robert C. Denove William Kassling The Honorable John E. Peterson William Watts Douglas P. Dick Mario Lemieux The Honorable John R. Pippy The Honorable John Weinstein Hillman Professor of Oncology Director, UPMC Cancer Centers and the University of Pittsburgh Cancer Institute George A. Fechter Sally Levin Jane Roesch Lee B. Foster Jeffrey Lipton Cynthia Roth John P. Friel David Malone Susan C. Santa-Cruz

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Lifting a Financial Burden for Patients

ike most of the country, western Pennsylvania has felt the financial impact of the current economy. Record high gas prices and the rising cost of food have forced many L Americans to tighten their budgets. Now imagine being diagnosed with cancer. Patients receiving cancer treatments are often unable to work due to the impact of both the disease and the therapy. In addition to normal day-to- day expenses, patients are dealing with costs for doctor visits, lab work, and other specialty care. Even with health insurance, the deductibles and out-of-pocket expenses can strain any budget.

According to medical oncologist Barry C. Lembersky, MD, a cancer diagnosis can place tremendous financial stress on a person.

“It is well-known that a cancer diagnosis has a wide-reaching effect on a patient’s life,” says Dr. Lembersky. “The disease can create an undue burden on those already with financial needs. In some cases, a patient may make the decision to forego treatment, with dire consequences for survival and quality of life.”

In 2005, UPMC Cancer Centers established the Patient Assistance Fund to help cancer patients across the network overcome some of the financial barriers associated with completing their treatment. The fund is designed to provide partial, short-term assistance to help eligible patients with care-related costs such as transportation, medical equipment, nutritional supplements, prosthetic devices, and lodging for themselves or family members.

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“By providing patients with temporary Lifting a Financial Burden for Patients continued financial relief, Making choices to make ends meet A supportive community they can concentrate When Darryl Wilson was diagnosed in 2006 with non-Hodgkin’s Over the years, the fund has received support from a variety of follicular lymphoma, he and his wife were not prepared for all sources. Local businesses, including Eyetique, Silpada Designs the extra expenses associated with cancer treatments. Jewelry, and Little’s Shoes, have held special promotions and donated on getting well.” a portion of their sales to benefit the fund. Kids and a Cause, Like many cancer patients, Darryl faced costs associated with a philanthropic organization put together by local children, Barry C. Lembersky, MD his treatment that seemed overwhelming. Darryl was unable to makes and sells purses to raise money. The members of the work due to the rigorous treatments, and his wife was working a organization chose to give the proceeds to the Patient Assistance limited schedule to take him to appointments. Although he was Fund because someone close to them received great care at Hillman receiving sick pay, it was not enough to cover the additional Cancer Center. expenses related to his care. Then the plant where Darryl had been working shut down. The couple needed to find a way to Even physicians and UPMC Cancer Centers employees have make ends meet. chosen to put their charitable dollars toward the fund to help patients. Dr. Lembersky, who is a major contributor, sees the A patient navigator at UPMC/Jameson Cancer Center helped fund as a way to help patients like Darryl to meet basic, everyday the Wilsons to explore ways to ease their financial burden. needs to live life beyond the scope of their treatments. Darryl and his family had no idea that programs like the Patient Assistance Fund existed. They credit the fund with helping them “The fund helps to make sure the rest of the patient’s life gets to pay for gas while he finished his radiation therapy. attended to as well.”

“I realize that everyone has problems, but overcoming obstacle Since its inception, the fund has helped more than 700 patients after obstacle became the central theme throughout my treatment. throughout western Pennsylvania. The Giant Eagle gift cards came at the right time, and enabled me to finish my radiation therapy,” Wilson said. For more information about donating to the Patient Assistance Fund, Throughout the UPMC Cancer Centers network, managers, social please contact UPMC Cancer Centers and UPCI Development Office workers, and at some sites, patient navigators are available to counsel at 412-623-4700. patients experiencing financial hardships about available resources.

“When a patient has needs that are not met after exhausting external programs, our staff can recommend the patient for assis- DeeDee Sacco’s Fight for Life tance through the fund,” says Lyn Robertson, DrPH, associate director, Cancer Control Services, UPMC Cancer Centers. Undergoing treatment at Hillman Cancer Center for a rare sarcoma of Alana Sacco, DeeDee’s mother and chairman of the board for the organization, “When I wear the bracelet people approach me and ask where I got it,” says the lung, DeeDee Sacco became friendly with another patient while they has found a sense of joy in raising money for the Patient Assistance Fund. Mrs. Conroy. “Then they tell me where they got their bracelet and it usually The Patient Assistance Fund can provide up to $500 in support were both participating in a clinical trial. The woman appeared to be very “Knowing this is what DeeDee would have wanted got the committee started,” leads back to our organization. It’s been a great experience.” to a qualifying patient during a 12-month period. Giant Eagle ill. When DeeDee asked her why she was so sick, the woman told her it says Mrs. Sacco. “Having helped so many families get through difficult times DeeDee Sacco’s Fight for Life also hosts an annual cocktail party at the gift cards are popular, because patients can use them to purchase was because she could not afford her prescriptions. gas, groceries, and nutritional supplements. The funds also can keeps us going.” LeMont, located in the Mount Washington section of Pittsburgh, and a golf be used to pay for durable medical equipment and wigs. DeeDee decided that it was her mission to give other cancer patients the In January 2008, DeeDee Sacco’s Fight for Life presented UPMC Cancer Centers outing at Hill Crest Country Club, located east of the city. support that she was so fortunate to have. with a check for $70,000, bringing the group’s grand total to $155,000 over According to Mrs. Sacco, the organization owes its success to all of the Throughout her own treatments she offered fellow patients emotional the past three years. volunteers. support, and sometimes even financial support, when needed. The volunteer organization has raised more than $30,000 through the sale “I can’t say enough about how generous our supporters and volunteers have Although DeeDee lost her battle with cancer in 2004, her passion to of bracelets featuring a of 12 colors representing different types of been. We could not have helped as many families without their commitment. help other cancer patients lives on through her family and friends. They cancer. Silvana Conroy, a childhood friend of DeeDee’s and president of the DeeDee would have been proud.” continue to celebrate her life and her dream by raising funds through organization, says that the bracelets have created a far-reaching bond. DeeDee Sacco’s Fight for Life, a non-profit organization benefiting UPMC For more information about the organization, visit its website Cancer Centers’ Patient Assistance Fund. at www.deedeefightforlife.org.

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Despite the growing number of advanced cancer therapies, Simplifying many Americans are still not receiving adequate cancer care. A landmark article in theComplex Worldof The New York Times brought to light this stark reality: a substantial number of Cancer patients are getting lost in our complex medical system.

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Simplifying the Complex World of Cancer continued

A journey from frustration At UPMC Cancer Centers, multidisci- A coordinated, Mr. Birchfield says that his experience to treatment plinary clinics bring together a team personalized approach with the Pancreatic Cancer Center has of specialists — medical, radiation, and been tremendous. “When I came to Sam Birchfield’s journey through cancer The cornerstone of the multidisciplinary surgical oncologists; disease-specific Pittsburgh for my initial evaluation, I began with a simple fall down the stairs approach is the close coordination with specialists such as gastroenterologists, never expected that I would meet all the while on vacation. After the fall, he the referring physician. Once a treatment pulmonologists, and neurologists; and doctors, have additional testing, and leave developed pain and heartburn that would plan has been developed, the team pathologists and radiologists — to expe- with a treatment plan in place. They not go away. At first he and his wife provides immediate feedback to the dite patient evaluations, saving valuable have been wonderful helping me when dismissed the symptoms as indigestion, referring physician to ensure a complete time. Clinics are setup by cancer type, I am in Pittsburgh and coordinating but after returning to his hometown of continuum of care. including adult neurological, breast, head my care with my oncologist in Texas.” Dallas the symptoms persisted, so he and neck, lung, lymphoma, pancreatic, made an appointment with his primary “The collaborative framework of the and thyroid cancers. care physician. multidisciplinary clinics enables the team to work through the complexities Newly diagnosed patients work with a Mr. Birchfield’s doctor first suspected of each individual case to develop the coordinator who serves as the point that his pain was related to bruising and most appropriate treatment plan,” says person for the treatment team — inflammation from the fall, but testing David L. Bartlett, MD, chief, Division reviewing the patient’s history and revealed that his gallbladder wasn’t of Surgical Oncology, and director, making appropriate appointments functioning properly. He had surgery UPMC Cancer Centers Multidisciplinary based on the patient’s needs and the to remove the gallbladder, but the pain Clinics. “The goal is to deliver a coordi- team’s recommendations. Supportive did not go away. After further testing, nated, personalized approach to each services, such as nutrition experts, a small mass was discovered on his pan- patient and their family during this behavioral medicine, palliative care, creas, which was eventually diagnosed stressful period.” pain and rehabilitation services, as adenocarcinoma. His surgeon in Texas oncology social workers, and cancer felt that the mass was inoperable and education specialists, are also part of the made recommendations for palliative multidisciplinary team to enhance the care to make him more comfortable. patient experience. his can be especially true in the Frustrated, Mr. Birchfield began a nation- Another important component of the complex world of cancer care. wide search for alternative treatment multidisciplinary model is the incorpo- Developing an effective treatment options, which ultimately led him to the ration of clinical trials in the treatment T plan for cancer often involves Pancreatic Cancer Center of UPMC plan, combining innovative and prom- input from a wide variety of specialists. Cancer Centers. For many patients the time from diag- ising clinical trial options with the best nosis to the start of treatment can be “By the time a patient like Mr. Birchfield standard-of-care therapies for each frustrating and lengthy. has seen all the specialists, valuable time cancer type. may have passed,” says A. James Moser, “One of the most important functions To eliminate the disjointedness that MD, co-director, Pancreatic Cancer Center. of a disease-oriented program is to exists for newly diagnosed patients, “For certain cancers, the patient may provide an infrastructure for physicians UPMC Cancer Centers has developed become too frail for treatment which to collaborate with clinical researchers disease-specific multidisciplinary clinics might otherwise have been possible.” where patients see the entire team of to develop novel therapies,” says Frank specialists in a concentrated period of Lieberman, MD, director, Adult Neuro- time, expediting the development and oncology Program. “Clinical trials are implementation of a treatment plan. significant to the development of new therapies that may improve patient outcomes.”

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Major gift funds research for Finding Link hereditary breast cancer

he discovery of the correlation between mutations in the genes called Breast Cancer 1 (BRCA 1) and Breast Cancer 2 (BRCA 2) and hereditary breast, ovarian, pancreatic, and prostate cancers T has given this generation hope that one day their children may be able to prevent cancer.

More than a decade ago researchers identified that BRCA 1 and BRCA 2 genes, when changed or mutated, increase the risk of certain cancers. Since this discovery, much effort has been directed towards investigating fundamental questions about hereditary cancer risk and the role of BRCA mutations. And while the answers to these and other related questions may lead to better early detection methods and treatments, our understanding of the roles these mutations play is still in its infancy.

Thanks to a $1 million commitment from the David S. and Karen A. Shapira Foundation, a new program at the University of Pittsburgh Cancer Institute (UPCI) and Magee-Womens Hospital of UPMC is addressing these key questions. The gift is structured as a matching grant to raise an additional $1.5 million from individuals and foundations. UPMC is matching these gifts on a dollar-for-dollar basis, for an overall goal of $5 million. The Frieda G. and Saul F. Shapira BRCA-Associated Cancer Research Program, named to honor the parents of David Shapira, chairman, president, and chief executive officer of Giant Eagle, Inc., is focused on advancing the understanding, prevention, early detection, and treatment of BRCA mutation-associated malignancies.

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Finding the Family Link continued Screening and early detection Another goal of the program is to develop a reliable, preclinical blood test to detect cancer in high-risk women. Women who test positive for a BRCA mutation are at the highest risk for breast cancer. A blood test could help to identify cancer earlier, leading “The program is one of the most focused of its kind,” said to more effective treatments and better long-term survival. Ronald Herberman, MD, director, UPCI and UPMC Cancer “Currently the best tool we have to screen women is mammography, Centers. “The more we learn about these mutations, the better which does not always identify small lesions,” says William Bigbee, chance we have to target high-risk people and to find innovative PhD, co-leader of the program’s breast cancer biomarkers ways to reduce their cancer risk.” discovery project. “Early-stage breast cancer is often difficult Research projects in the program include: to identify using mammography alone, particularly in pre- menopausal women with dense breast tissue.” • a comprehensive registry and specimen bank to facilitate BRCA 1- and BRCA 2-related research Dr. Bigbee and his colleague, Thomas Conrads, PhD, who are co-directors of the Clinical Proteomics Facility at UPCI, hope to • proteomics research into the discovery of breast cancer identify and validate serum-based biomarkers, a characteristic biomarkers indicating the presence of disease process, using state-of-the-art proteomic technologies to further improve breast cancer • a multi-marker approach for a blood test for early detection of screening, early detection, and diagnosis. breast or ovarian cancer in BRCA-mutation-positive women The ultimate goal is to use this information to create a molecular • cancer-risk prediction in daughters of BRCA 1- or BRCA 2- blood test to complement existing clinical screening methods, mutation carriers to identify opportunities for prevention such as mammography, that will assist radiologists and oncologists • prediction of breast cancer risk among individual BRCA 1- in determining whether or not suspect lesions are precancerous or BRCA 2-mutation carriers or cancerous.

• risk analysis and risk reduction targets based on gene-environmental interactions Who is at risk? Individuals with a BRCA mutation are not only at risk for breast cancer. Male and female BRCA mutation carriers also have an A powerful resource for research increased risk of ovarian, prostate, and pancreatic cancers. The At the heart of the program is the establishment of a comprehensive High-Risk Clinic at Magee counsels and treats women and men registry and specimen bank that will serve as a powerful resource with a strong family history of these cancers. Information gathered for a wide range of studies by providing investigators with ongoing at the clinic will be used to build the registry and specimen bank. access to clinical samples, as well as demographic, pedigree, and genetics data for BRCA-mutation carriers and non-carriers. Although most breast cancers occur in women who do not have a strong family history of the disease, about 10 percent are linked To be or not to be (tested)… Kristin K. Zorn, MD, an expert in gynecologic oncology at Magee, to a genetic predisposition. In the United States, it is estimated It’s been nearly ten years since Titina Ott received time I was concentrating on my career and wasn’t an oncologist once a year. She credits the clinic is collaborating on the development and management of the that somewhere between one out of 345 to 1,000 individuals carries the news that a relative tested positive for a BRCA really thinking about health issues,” says Titina. with giving her more awareness and education registry and specimen bank with Darcy Thull, MS, CGC, of the a BRCA mutation, and for individuals of Ashkenazi Jewish decent, mutation. Her father’s cousin decided to have the about being in a high-risk group. She also has UPMC Cancer Genetics Program. the number is approximately one in 40 individuals. Pittsburgh has The reality of Titina’s own cancer risk hit home genetic testing done after losing her mother to become passionate about encouraging women to a relatively large Ashkenazi Jewish population. when her best friend from college was diagnosed “Over the last decade there has been a real recognition, both breast cancer and finding a lump of her own. For with Stage III colon cancer. Her friend’s mother had take an active role in their health. nationally and internationally, of the importance of specimen “The BRCA-Associated Cancer Research Program brings together Titina’s cousin it was an easy decision to be tested. passed away from complications of Stage IV colon “I am 100 percent more proactive in my life banking. But the problem is doing it effectively,” says Dr. Zorn. innovative researchers with physicians who clinically treat The cousin decided that she needed to share this cancer, prompting her friend to get tested for colon knowing I am part of a high-risk group,” says information with her relatives, so that they too could “It is very expensive to harness all the resources to collect specimens patients with these types of cancers, giving us the opportunity to cancer and ultimately saving her life. This was a Titina. “You only have one life to live. Education make the decision to be evaluated by a genetic and bank them appropriately. We are fortunate to have donors not only treat the patients and help them to manage their risk, wake-up call for Titina. has helped me to make better choices that counselor. The decision was not as easy for Titina. who recognize the importance of the basic work of building the but to learn from them so we hopefully find better answers for She now takes her risk very seriously. As a patient potentially may prevent cancer. I want to empower registry and continuing specimen banking.” their children,” says Dr. Zorn. She discussed getting tested with her family and at the High Risk Clinic at Magee-Womens Hospital other high-risk women to take advantage of as eventually decided not to be tested. “I found out about of UPMC, she gets regular breast MRIs and sees many opportunities as possible to decrease their my family’s risk when I was in my early 30s. At the risk as well.” Image of BRCA 2 gene courtesy of RCSB Protein Data Bank. Yang, H., Jeffrey, P.D., Miller, J., Kinnucan, E., Sun, Y., Thoma, N.H., Zheng, N., Chen, P.L., Lee, W.H., Pavletich, N.P. (2002) BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 297: 1837-1848

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Educating On any given day, travelers driving through the quaint, rolling farmlands of western Pennsylvania may encounter Amish neighbors commuting to local towns by the‘plain’ horse-drawn buggy where their traditional way of life intersects with the modern world. community

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In October 2007, ROCOG coordinators brought the first breast and cervical cancer screening to an Amish community in Somerset, Pa.

The Amish, who are known hanks in part to a grant funded Dwight E. Heron, MD, principal inves- Through an existing relationship with In October 2007, ROCOG coordina- “Community outreach and patient by the National Cancer Institute, tigator of the grant and director, Radiation professionals from the Pennsylvania tors brought the first breast and cervical navigation go hand-in-hand,” says Karen for their simple lifestyle, clusters of Amish throughout Oncology Services, UPMC Cancer Department of Health, nurse educators cancer screening to an Amish community Schwaderer, RN, BSN, OCN, director, typically shun the outside T western Pennsylvania are gaining Centers, underscores the importance of from the ROCOG project were intro- in Somerset, Pa., located southeast of Patient Navigation and Clinical Services. access to valuable cancer education and building trusting relationships and making duced to Amish communities in western Pittsburgh. Seventeen women came to “You can’t go into an underserved, world, restricting their use screenings utilizing education methods cancer education understandable and Pennsylvania. The nurses held discussion the screening, with three of the women uninsured community like the Amish, sensitive to their needs. relevant to people in communities like groups with Amish women from two showing abnormal test results. These and not help them to gain access to of modern conveniences and the Amish. different sects to assess the communities’ three women, who were not insured, were treatment.” seeking medical attention The Amish education program was needs and to identify ways to provide then assimilated into the Healthy Woman developed as part of the Radiation “Trust was an essential component,” cancer education. Project, a state program dedicated to To date, more than 125 only when needed. Their Oncology Community Outreach Grant explains Dr. Heron. “By understanding helping economically disadvantaged beliefs, until recently, have (ROCOG) project, which promotes the their needs and respecting their values, The idea to print articles in a local women gain better access to care. Amish have been helped use of non-traditional outreach to make we have been able to make great strides newspaper with a section dedicated to directly through screenings limited their access to state-of-the-art cancer care available to in bringing cancer education to the the Amish came from the discussion disadvantaged communities. Amish communities throughout western groups. The articles are written by the and education provided by preventive health care, Pennsylvania.” cancer education staff and edited by such as cancer screenings an Amish volunteer to accommodate the program. language barriers. The articles are and education. printed every few months and cover a variety of topics, ranging from basic information about specific cancer types to dealing with death.

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the Power of Partnership

Thanks to the continuing support ENDOWED CHAIRS Mario Lemieux Foundation Michael J. Parada Research Fund Tamar and Seth Brufsky Cathy and Sy Holzer The Leukemia and Lymphoma Society Mark E. and Leah M. Pasquerilla The Caliban Foundation Roy A. Hunt Foundation An important number of endowed chairs support the mission of our donors, the University Richard King Mellon Foundation Women’s Cancer Research Fund Barbara and Gerald E. Chait Jean and Samuel Jacobs, MD of UPMC Cancer Centers and the University of Pittsburgh Susan G. Komen Breast Cancer Foundation Pasquerilla Cancer Genomics and Proteomics Susan and Alan Citron Janis and Jonas Johnson, MD of Pittsburgh Cancer Institute and Cancer Institute. The income generated from endowed chairs Arnold D. Palmer 2003 Charitable Trust Research Fund Carl Citron Betsy and Robert Kampmeinert enables our scientists and clinicians and their teams to strengthen Mark E. Pasquerilla Linda Saulle Endowed Memorial Fund Mr. and Mrs. Henry L. Clement, III Linda and Frank Kass UPMC Cancer Centers are established areas of expertise, expand new initiatives, and forge PNC Financial Services Group and PNC Foundation Frieda G. and Saul F. Shapira Mary and Jay Cleveland Jr. Greta and Amin Kassam, MD new frontiers in science that benefit our patients and their translating new discoveries in The Pittsburgh Foundation BRCA Cancer Research Fund Sandra S. and Richard A. Cohen Tricia and William Kassling families now and into the future. the laboratory into effective Myles D. Sampson* and Family Frieda G. and Saul F. Shapira Caryn and Sam Covelli Dini Katz The David S. and Karen A. Shapira Foundation BRCA Endowed Cancer Research Fund Barbara Ann and Robert A. Crown Karen and Joseph L. Kelley III, MD The Claude Worthington Benedum Endowed Chair Theresa Heinz and The Heinz Endowments The Spang Translational Research Core Facility Randi and L. Van Dauler Jr. Kathryn and Cary Klein methods for preventing, detecting, in Radiation Oncology Sandra and Thomas Usher Joseph and Giovanna Tarquinio Memorial Fund Jamini Vincent Davies AJ & Sigismunda Palumbo Charitable Trust on behalf of The Jane and Carl Citron Endowed Chair and treating cancer. Gifts received Debi and Harold W. Wheeler III Wayne Fusaro Pancreatic Cancer Research Fund Devra Lee Davis Charitable Trust on behalf of Frank W. Knisley* in Colon Cancer Wheeler Family Charitable Trust Dr. Leonard S. Zombek Memorial Fund Devra Davis, PhD, MPH, and Koch Family during fiscal year 2008 are The Richard M. Cyert Endowed Chair * deceased Richard D. Morgenstern, PhD Valerie R. Koch in Molecular Oncology ______Ann and Edward Dunlap Curtis I. Kossman Foundation bringing renewed hope to The Gregory T.H. Davies Endowed Chair ______ANNUAL GIVING Mary Jo and Terry Dunlap Laura and Claude Kronk in Brain Tumor Research and Physician Education cancer patients and their families FAMILY LEGACY SOCIETY The Annual Fund provides vital support for the operation of Mary Lou and Richard Durr Beth and Michael Kuhn The Lawrence Ellis Endowed Chair Often, a personal experience with cancer or the loss of a loved clinical programs, basic and clinical research programs, Amy and Phil Elias Marina and Kenneth Lehn, PhD in our region and beyond. It is in Hematology and Oncology one to the disease spurs a family to establish funds that honor a recruitment of new physicians and scientists, seed money Lori and Peter Ellis, MD Nathalie and Mario Lemieux The Bernard Fisher Endowed Chair in Surgical Oncology patient or caregiver through support of continuing efforts to support, medical and patient education, and outreach programs. Gloria T. Fader Robert Levin with deepest gratitude that we The Giant Eagle Foundation Endowed Chair better detect, prevent, and treat cancer. Those listed have made sustained annual investments at the Michael Fader Sally Levin in Cancer Genetics recognize our partners — following designated levels. Diane Faust and Barry Lembersky, MD Shelley and Jeffrey Lipton The Hillman Endowed Chair in Oncology Suzanne Hill Alfano Endowment Milton and Sheila Fine Lynn and Robert v.d. Luft individuals, families, businesses, The Arnold Palmer Endowed Chair in Cancer Prevention ______for Lung Cancer Research Stephanie and Thomas Flannery Christine and James D. Luketich, MD The Sampson Family Endowed Chair CIRCLE OF HOPE Nathan S. Arenson Fund for Pancreatic Cancer Research Kimberly and Curtis Fleming Reena and Baljeet Mahal, MD corporations, foundations, in Thoracic Surgical Oncology The Circle of Hope honors individuals, family foundations, Adriane R. Aul Memorial Fund Foster Charitable Foundation at the recommendation of David J. Malone The Sandra and Thomas Usher Endowed Chair and privately held companies that make contributions of and organizations — for their Beckwith Family Foundation Endowed Research Issie and Lee Foster, Barbara and Bernard Mars, Stanley M. Marks, MD in Melanoma $10,000 or more in a calendar year. This list recognizes Scholars Program Wendy Mars, PhD, and Peter Mars Mars Family Charitable Foundation ongoing support of our mission to UPMC Endowed Chair in Head and Neck Cancer those who were members in 2007 and through 2008 to this The Heidi Browning Endowed Ovarian Cancer Research Fountainhead Foundation at the recommendation of Myrna and Mark Mason Surgical Research point of publication. Scholars Fund Charles Bitzer Kevin McClatchy build a future without cancer. UPMC Endowed Chair in Lung Cancer Research Ruth C. Brufsky Fund Jane K. France and Christian L. Allison L. Colvin and Madelaine McCrady Anonymous (3) for Clinical Research on Pancreatic Cancer Merle E. and Olive Lee Gilliand Foundation Linda and David McKamish ______Adams Capital Management Patti Burns Fund Sandra and Lee Goodman Michele McKenney and Charles C. Cohen VISIONARY SOCIETY Michelle and Andrew Aloe Dr. Joan G. Gaines Breast Cancer Research Fund Gott Family Foundation Kathleen and David McSorley These dedicated partners have given or helped to raise a Bruce Americus Stuart Goodman Brain Cancer Memorial Fund Mr. and Mrs. T.C. Graham Tracy and Ken Melani, MD cumulative total of $1 million or more in support of cancer Patrice and Robert Americus Peter E. Hackney Fund for Pancreatic Cancer Research Bonnie and Jonathan* Gray Moody and Associates, Inc. research and care. Ayers Foundation Harvey G. Herberman, MD Thomas B. Grealish Jane and Edward Moravitz Debbie and Michael Barbarita Memorial Cancer Research Fund Marcia and Stanley Gumberg Flo Mae and Stanley Moravitz American Cancer Society, Inc. Alfred R. Barbour* Dr. Herbert E. Jacob Memorial Fund Sara and Alan Guttman Donald A. Mosites DSF Charitable Foundation Rosalie Barsotti and Tony Poli Hyman I. Katz Cancer Research Fund Susan G. and Barney C. Guttman Theresa Whiteside Nimick, PhD, The Giant Eagle Foundation Beckwith Family Foundation at the recommendation of Barbara Klump Memorial Scholarship Fund Hawksglen Foundation and Thomas H. Nimick Jr.* Harriett and Ronald B. Herberman, MD Dotty and Nick Beckwith and Albert P. Knowles Research Fund Teresa Heinz and The Heinz Endowments Peggy and Jack Offenbach Highmark Foundation Alice and James* Beckwith David C. Koch Memorial Fund Heidi and Robert E. Heltzel Saundra and Gene O’Sullivan Elsie H. and Henry L. Hillman Renard L. Biltgen Mario Lemieux Patient Care and Cancer Research Fund Dara and John Henne Kit and Arnold D. Palmer Henry L. Hillman Foundation Mary Ann and Charles Bogosta Scott Limbach Entrepreneurial Center Harriett L. and Ronald B. Herberman, MD Leah M. Pasquerilla Hillman Foundation Barbara and Gary K. Bowser Sr. Stanley M. Marks, MD Endowed Research Fund Margaret M. and John B. Hill, MD Lisa and Mark E. Pasquerilla Family and Friends of Albert P. Knowles Susan and Michael Boyle Drew Mathieson Entrepreneurship Fund Elsie H. and Henry L. Hillman Kathleen and Demetrios Patrinos New Era Cap Charitable Foundation and Family Leslie and Matthew Braksick James A. Mollica Jr. Research Endowment Fund William Talbott Hillman Foundation Perlow Family and Friends of David C. Koch Jill Brufsky, PharmD, and Adam Brufsky, MD, PhD PNC Innovation Fund Joan and Daniel Hilson Donald Plung

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Hilary Tyson and Charles Porter LEADERSHIP CIRCLE Patricia and James C. Dewar Susan and Alan Patricof Genevieve and Paul B. Caton Joseph Shaw Jr. Shankar Ramchandran, PhD ($5,000 - $9,999) Douglas P. Dick Rosemarie and Kiran K. Rajasenan, MD James F. Cawley Beverly and Martin Walsh Sheerer David Rath Susan and Thomas Aul Laura E. and Alfred P. Doyle, MD Lucile and Ian Grant Rawson, PhD Manisha and Preet M. Chaudhary, MD, PhD Pamela and Kenneth C. Sprague and Frank Rath Beverly and Jeffrey Berger Sally H. Durrant, Esq, and Robert E. Durrant, Esq Maria and Fred P. Raymond Connie and Bruce T. Cleevely Daniel M. Stiegler, DDS, PC Lillian S. Rath H. Adam Cohen Karen and Michael M. Dvorsky Thomas Merrill Reich Kelly and Thomas Conrads, PhD Jean and Charles J. Stout Joseph Rattner Memorial Endowment Fund Malindi Davies Lisa and Martin F. Earle, MD Larry Rich Elisa D. Harris and Ivo H. Daalder Cindy L. and David P. Swanson Rauch Foundation Joyce and Stanley H. Goldmann Lowrie C. Ebbert Deborah and Anthony Ricottone, MD Armand C. Dellovade Evelyn Oshinsky Talbott, DrPH and John B. Talbott, MD Riggs Industries, Inc. Mary Jane and Carl G. Grefenstette Karen and Merrill J. Egorin, MD Mona and Robert W. Riordan Gary Dille Sara B. Thompson Roesch Family Foundation Nancy Hamilton Sally and Terry Lynn Evans, MD Stephen G. Robinson Ruth D. Egler Barbara Ellen Trachtenberg Stefania and Jeffrey Romoff Dwight E. Heron, MD Mary Ellen and William A. Ferri Jr., MD Linda and James P. Rosenbloom David R. Fitzsimmons Michael T. Vargo Cynthia Roth and James Kunkel, MD Richard P. Krieger Patricia and Thomas H. Frauenheim Louisa S. Rosenthal Jane C. and Michael J. Fleischauer Bernadette and Ken Vehec Diane and Cliff Rowe Jr. Paula M. Lockhart John J. Fromen Jr., Esq Nancy Rozendal Keith E. Fox Margaret and Sam S. Vidnovic Linda and Jim Rumbaugh Juliet Lea Hillman Simonds Beth Ann and Frank B. Fuhrer III Judy and Stanley C. Ruskin Mr. and Mrs. Thomas P. Frizzell Diane and Jonathan Webber The Rust Foundation Paulette and David Francis Stefanik, MD Sally Weigler Golden and Thomas B. Golden Jr. Cindy and Andrew Russell William Frucht Elizabeth and Robert B. Weidlein Abby and Reid Ruttenberg Jeffrey W. Tott Shirley and Robert M. Gordon Jeremy M. Shapira Dolores and Robert Gabler Farley W. and Joshua C. Whetzel Jr. Sampson Family Foundation Susan and Robert J. Weis Jennifer Grandis, MD and Donald J. Grandis, MD Elizabeth A. and Eric A. Shiring Maryedna Gillespie-Gennaula Sally Wiggin Kim and Ben Sampson Ina and Lawrence N. Gumberg Patricia and Alan L. Siger Leslie Alan Goldstein, PhD George C. Wilson III David Scaife ______L. Malcolm Hamilton Karen Shakoske and Henry Simonds Ruth A. Modzelewski, PhD and Michael C. Gorry Lisa Wolf Ritchie Scaife PARTNERS FOR PROGRESS Dana and Franco Harris Mary and Richard Skubak Timothy W. Gray Shannon and Gary J. Wroblewski Mikell and A. William Schenck III ($1,000 - $4,999) William A. Hite Raymond V. Sozzi James R. Grundtisch Ornella Pagliano and Hassane Mohamed Zarour, MD Tracy and Evan J. Segal Adrianne and Curtis Aiken Cecelia and Frank G. Jaworowski Jeffrey Wayne Spear, Esq. Susan and David H. Hicks Walter R. Zoladz III Cindy and David S. Shapira Jill and Dennis L. Astorino Susan J. Johnson Valerie J. Stabile Gloria K. Janavitz Deborah Shapira and Barry Stern, PhD Kimberly and Peter M. Augustine Timothy L. Kane Lorene and Ronald C. Steffes Rebecca Lahniche ______Edith Shapira, MD, and Mark Schmidhofer, MD Paul J. Balbierz James E. Kelly, Esq Shirl and Mark Lee Unatin Ann Marie Langerholc AMBASSADORS Barbara and Herbert Shear Eugene Bang Gauri J. Kiefer, MD and Jan F. Kiefer Millie and Rade Vignovic Claire and Lawrence Levine ($250 - $499) Jacqueline and Jeffrey Shogan, MD Mark Barbustiak Joanne and Harry E. Knapp Saralyn S. Vogel, MD and Victor G. Vogel, MD Julia and Scott A. Lewis William J. Adams Gayle and William Simpson Caroline and Robert Barmen Frank Kopfer Suzanne and Richard L. Wagner Brian Limbach Nicholas E. Andrews Sharon and Bob Slagle Ellie and Stewart B. Barmen John Daryl Kristofic, MD Matthew B. Waldman Linda and Eric Limbach Donna M. Artz Rebecca C. Snyder Jennifer and David Barnard Susan and Scott M. Lammie Lisa and Peter J. Walsh Debra and Kurt Limbach Steffler Newlin Balsley G. Whitney Snyder Charitable Foundation Denise and Raymond L. Barry Jr. Frances S. and Stewart L. Lancaster, MD Naomi and Peter B. Waltman Carol and Mark Limbach Lynne and Roger L. Barna Stork Foundation Susan and David Bartlett, MD Alan David Levenson Karen Marcus and S. Rand Werrin, DDS Anna Lokshin, PhD and Peter Gordon Robert W. Bersick, DDS Marcia and Perry Swanson Mary Murtland Berger Robert J. Lewis Christine A. and David C. Whitcomb, MD, PhD Holly Lorenz Tuija and Charles David Blumenschein Janet and George Taber Patricia and Sanford S. Berman Nancy and Henry M. Liao Mignon and Waldemar J. Love Helen C. Brooks Pamela and Markos Tambakeras Family Foundation James D. Berry III Terri and Timothy J. Logan ______Annette and Gary Luchini Ann and Roger S. Brown The Tippins Foundation Marjorie Romkes, PhD, and William Lyman Bigbee, PhD Stephanie and Bernard Mallinger, MD CHAMPIONS Lois and David E. Malehorn Cheryl Burger Gayle L. Tissue and Yiannis Kaloyeropoulos Debby and Daniel Irvin Booker Joan Marshall ($500 - $999) Helen and Curtis R. Marquard Paul J. Cardillo Sandra and Thomas Usher Nancy Beranbaum Brent, MD, and David A. Brent, MD Susan and Geraldo J. Matos Elinor M. Abplanalp Anne and William O. McConnel J. Brad Chambers Bonnie W. and Tom L. VanKirk, Esq. Sheryl and Jeffrey S. Broadhurst Randall and Leslie Merrill McCombs Nicholas James Alfano Barbara S. Mendlowitz Kathryn and Edwin V. Clarke Jr. Kristina and William Watts Tracy Seewald, MD, and Steven A. Burton, MD Denise and Gerald R. Medwick, MD Patricia and Thomas J. Antos, MD Constance and Bruce W. Morrison Pam and Peter Countouris Marilyn and Norman Weizenbaum Carolyn and William Byham Emily Solomon Mendelson Yoshio Ari Dana and Daniel A. Nestel Joyce and Martin J. Dambekaln Debi and Harold W. Wheeler III Margaretha L. Casselbrant, MD Kate and James Meyers, PhD Amy and David M. Bahm Alice Hopkins Newton Beth W. and Elliot S. Davis Wheeler Family Charitable Trust Naomi and Jesse J. Cohen Scott A. Molander Kathryn A. Barbustiak Cathy and Richard M. Pieper Michele and William M. DeLuca Priscilla and Joseph Whiteside Sharon Cowden, MD and Jere L. Cowden Yuan Chang, MD, and Patrick S. Moore, MD Shilpa and Sushil Beriwal, MD Stephen R. Powers Frank H. Dettore Josephine and S. Donald Wiley David W. Croyder Beatrice and Samuel Moore George M. Blair John Charles Regan Georgine A. Dorundo Eleanore G. Wyckoff Nancy and Paul M. Cryder Frances Niovich Michael Boyiadzis, MD Carol J. and Patrick R. Riley Mary Ruth Sampson Eckman William D. George Wyckoff Eileen D’Appolonia George A. Griffith and Thomas J. O'Brien Carole and David E. Brougher, MD Ann A. Rogers Colleen M. Ellis Robin and Gary Zentner Marian and Stanford G. Davis, Esq Brian J. O’Mara Barbara R. Burger Nathan Rupnik Jennifer and Howard Epstein Jennie Zoline Foundation Dolores and Joseph W. DeNardo Albert P. Panza Mary S. Burt Maureen and Richard J. Saab, MD Anne F. Favo * deceased Ellen and David L. DeNinno Elaine and Danny K. Park Sara and John W. Buss Jr. Teresa M. Savolskis Robert L. Ferris, MD, PhD

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Rebecca Garrett, MD and Kenneth Foon, MD John Pitarresi ESTATES AND TRUSTS Creative Displays & Packaging, Inc. Radelet McCarthy, Inc. Houston Harbaugh P. C. Susan S. Fuhrer Mildred Posvar UPMC Cancer Centers and the University of Pittsburgh Drinker Biddle & Reath LLP RedPath Integrated Pathology, Inc. The InterPublic Group of Companies, Inc. Dolores and Eddie Gluck Sandra and Bartley J. Rahuba Cancer Institute gratefully acknowledge gifts from the following Evans City Elementary School S&T Wealth Management Group IRX Therapeutics, Inc. Richard C. Harris Susan M. Rakfal, MD individual estates and trusts. Fifth Third Bank Schnader Harrison Segal & Lewis LLP James S. Gunst Co., Inc. Faith A. Harty Marcie and Barry S. Reese Hefren Tillotson Speed Motor Express of W.N.Y., Inc. John Hancock Financial Services, Inc. Peter John Karlovich and Steven R. Herforth Rita H. Reese Estate of Robert M. Colteryahn Ladies Hospital Aid Society of Western Pennsylvania United Parcel Service Kamin Realty Company c/o Daniel Kamin Sydney and Erich Hoffmann John D. Rhodes Estate of Clara Luitz McKamish Inc. Van Dyk Business Systems Landon Butler & Company LP Jean L. Hort Susie and Greg Rice Estate of Miriam Renton Richards MGI Pharma, Inc. – Dr. and Mrs. Ronald G. and Judith K. Linaburg Lawley Agency Insurance Richard A. Hundley Suzanne and David Richardson Estate of Sherman H. Siegel Oxford Development Company VF Services, Inc. M & T Bank Joanne Louise Irwin Mavis and Norman Robertson Pittsburgh Steelers Sports, Inc. Workflow One M & T Insurance Agency, Inc. Carol and Robert E. Ives Sharon Semenza and William M. Robinson ______Pittsburgh Wine Festival, LLC The Martin Group, LLC Sandra L. and Edward A. Jaeger, MD Mona and Garson David Roodman, MD BUSINESS, CORPORATIONS, ADVOCACY PJ Dick, Trumbull, Lundy ($1,000 - $4,999) McMahon and Cardillo Communication, Inc. Sarah and Lewis K. Johnson Elizabeth and Keith Schanck ASSOCIATIONS, AND OTHER GROUPS Precision Therapeutics, Inc. Alco Parking Corporation Milliken & Company Susan A. Blanchard and Lee M. Kalik Eric Scher UPMC Cancer Centers and the University of Pittsburgh Riggs Industries, Inc. Alliance Bernstein, LP Nuveen Investments Frances and David N. Kaplan Mary and Charles Jacob Schneider Cancer Institute gratefully acknowledge gifts of $250 or Roomful Express Alliance Capital Management Corporation Ogletree, Deakins, Nash, Smoak & Stewart, P.C. Peter and Sally E. Kay Kevin P. Schombert more from businesses, corporations, advocacy associations, The Savings Bank Life Insurance Company American Coaster Co., Inc. Partners In Change, Inc. Allen Kidd Laurie Schoonhoven and other groups. of Massachusetts Astorino Development Phillies Donald B. Kienholz Caren Glotfelty and Wim Schoonhoven UPMC Presbyterian Hospital Barudan America, Inc. Pietragallo Gordon Alfano Bosick & Raspanti LLP John H. Kunkle Jr. Doris M. Scott ($100,000 + ) BHNT Architects, P.C. PNC Financial Services Group, Incorporated Dolores and John D. Kyriacopoulos, MD Jewel M. Slepchuk American Cancer Society, Incorporated ($5,000 - $9,999) Bison Baseball Inc. The PNC Foundation Lois and Dan R. Lackner Lois T. and Ross H. Smith Jr., MD Anonymous Active Media Services, Inc. BlackRock Financial Management, Incorporated PNC Wealth Management Patricia and Thomas C. LeClere Shannon and Ryan P. Smith, MD Fraternity and Sorority Life Office Barudan America, Inc. Bond, Schoeneck & King, PLLC Polakoff Sports Sales Inc. Byeong Chel Lee, PhD John C. Sowa at the University of Pittsburgh CDM Buffalo Neurosurgery Group Project 2050, Inc. Mary M. Lee Molly and Anthony Spinola, MD GIST Cancer Research Fund Elizabeth and Michael Concordia Cancer Awareness Fashion Show c/oTherezia Alchoufete Silpada Designs Jewelry Yun K. and Yong J. Lee Barbara and Louis A. Steiner The Institute For Transfusion Medicine Evans City PTO Capitol Container, Inc. Speed Global Services Cheryl A. Leleck George E. Steins Evans National Bank Carson City Saloon St. Andrews Products Mary Carol and John F. Lewis Miss Takako Tajima and Family ($50,000 - $99,999) FEDEX Trade Networks Colgate-Palmolive Company Sterling Mets, LP Jane V. and Howard M. Love Rabab and Ahmad Tarhini American Lung Association Firstgiving, Inc. Curbell Swartz Campbell LLC Lynn and Allen J. Mandel Edward Teeple Jr. The Brain Tumor Society, Incorporated Friends of David C. Koch Golf Tournament Cynthia’s School of Dance & Swissvale Boro Fire Fighters Dorothy Maritime Juliann Summerville Truver Panera Bread Friends of Plum Running Mustangs Alumni Association DHJ Canada, Incorporated SX Management, LLC Christie Markkowitz Mary and John C. Unkovic Georgiades Surgical Associates Dickie, McCamey & Chilcote The TJX Companies, Inc. Raymond J. Mauro David Schenck Van der Voort ($25,000 - $49,999) Global One Headwear Eagle Buckram Co., Inc. Transportation Marketing Services International, Inc. Edward J. McClain Jr., MD Nancy L. Vareha American Heart Association Golf Management Corp. E.C. Johnson Refrigeration Service UB Foundation Activities Inc. Jean Humason McCullough Gertrude and Lawrence M. Wagner big Burrito Restaurant Group GPS Construction Services LLC c/o Eugene C. Johnson Uniontown Hospital Andrew S. McElwaine Zinfeng and Qingde Wang, MD, PhD Buchanan Ingersoll & Rooney PC HemaQuest Pharmaceuticals, Inc. Empire Financial Partners United Business Systems, Inc. Laura and Charles McGortey Susan E. Weintraub MedImmune, Inc. Littles of Pittsburgh Inc. Engineered Products, Inc. West Herr Automotive Group, Inc. Patricia and John L. Mehltretter Marcia J. Weiss United States Steel Corporation Management Engineering Corporation Eyetique Corporation William H. Prentice, Incorporated Irene Mellion Delphine and George M. Welch Wabtec Corporation Marsh USA Fiserv SourceOne Gail and Robert Miller Jr. Helen and John B. White Massaro Corporation Fox Sports Net Pittsburgh, LLC ($250 - $999) Tracey and D. Scott Mullins Elisabetta and Kurt Wiedenhaupt ($10,000 - $24,999) Medrad Friends and Family of Nancy Porada Giesmann All American Events Tours Lydia Neumann Laura P and Charles J. Williamson American Head and Neck Society Menlo Worldwide Logistics Friends of Dr. Howard Altman AMC Settlement Services, LLC Scott Offenbach Robert Zamule American Joint Committee on Cancer New York Yankees Genesco Argenio & Wolters Family & Friends Kaori and Hideho Okada, MD, PhD Meryl B. Zegarek American Textile Company Novartis Oncology Grant Oliver Corporation Associates at Respironics, Inc. Scott Oran Jian Yu and Lin Zhang, PhD Ares Management II, L.P. PB Americas, Inc. Hadley Exhibits, Inc. Blair Orthopedic Associates & Sports Medicine Ellen and James S. Pasman Jr. Joanne and Alan Ziperstein Babst, Calland, Clements & Zomnir, P.C. PBS&J Hannan Executive Services Inc. Boland Sales Company, Inc. Tammy and James S. Patterson Mary Ann and David E. Zucknick The Bank of New York Mellon Corporation Pfizer, Incorporated Hard Manufacturing Carnegie Mellon Entertainment Tech Center Alumni Sarah and Ryan Peasley Bombardier Transportation, U.S.A. Inc. Phillips Lytle LLP HealthNow New York, Inc. Carr Textile Corporation Bruno M. Peault, PhD The Buncher Company Pittsburgh Pirates The Hillman Company Cipriani & Werner, P.C.

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Demakos & Company RP Sales, Inc. Shawn Gaertner Foundation UNITED WAY David S. Kortze UPMC CANCER CENTERS AND Digital@Bates Jackson, LLC S & T Bank Merle E. and Olive Lee Gilliand Foundation Donors that designated United Way donations and/or pledges Joyce Krut UPCI DEVELOPMENT DEPARTMENT Ditto S. M. Cristall Company, Inc. GlaxoSmithKline Foundation of $250 or more in support of UPMC Cancer Centers or Karen L. Larrimer Jennifer Raetz, Development Director Diversified Inspections / ITL San Diego Padres L.P. Gott Family Foundation University of Pittsburgh Cancer Institute agency codes during Stanley and Nancy J. Lehman Kambra McConnel, Major Gifts Officer Eaton Office Supply Co., Inc. Saperston Asset Management, Inc. Hawksglen Foundation the 2007 United Way and United eWay Campaigns Jeffrey M. Lipton Jennifer Zgurich, Major Gifts Officer Employees & Management Selections by Genea & Eric Teresa & H. John Heinz III Charitable Fund (June 2007 through April 30, 2008). Holly Lorenz Norma J. McGowan, Manager at Specialty Medical Systems, Inc. Spearhead Transportation Services, Inc. The Heinz Endowments James D. Luketich, MD Jody Getsy, Administrative Coordinator Employees of New Era Cap Company, Incorporated Standard Insurance Company William Talbott Hillman Foundation Anonymous (11) Marc D. Marks Jennifer Zazzera, Administrative Coordinator F. O. E. PA. State Auxiliary T-Bones, Inc. The Orris C. Hirtzel and Beatrice Dewey Hirtzel Brian K. Beachy Stanley M. Marks, MD Katheryn Behrman Florida Marlins, L.P. Turkey Trot for Prostate Cancer Memorial Fund Kathleen Ann McFetridge ______William Lyman Bigbee, PhD Friends and Family of Philip M. Lynch United Steel Workers of America Local 6346-11 Mary Hillman Jennings Foundation Tamra E. Merryman, RN, MSN, FACHE and UPMC CANCER CENTERS AND UPCI Charles Bogosta Friends of Carol Jakiela The United Way of Washington County Roy A. Hunt Foundation Grant Merryman CAPITAL CAMPAIGN COMMITTEE (2008) Friends of the Browarsky Family UNO Restaurants, LLC. Kennametal Foundation Daniel M. Bonacci Natalie D. Miltenberger Honorary Campaign Committee FTI Consulting, Inc. The Washington Hospital Curtis I. Kossman Foundation William P. Brauer William R. Newlin Elsie Hillman Goya Foods Great Lakes WEA Corporation Lambda Foundation Ralph Caputo Thomas J. Nigra Valerie Koch The Hat Club, LLC Worthen Industries, Inc. The M & T Charitable Foundation Jeffrey D. Carter Anna M. Oliver Arnold Palmer Highland Carbide Tool Co., Inc. Zenner & Ritter, Inc. Mars Family Charitable Foundation Jody L. Cervenak Sean A. O’Rourke Jim Rohr Holy Cross Academy The Marsh Family Foundation Jane Clayton Larry Phillips Tom Usher Impact Consulting Services, Inc. ______Multiple Myeloma Research Foundation Michael D. Costelloe Phillip Rogers IMX Medical Management Services FOUNDATIONS Musella Foundation Sandra N. Danoff Douglas Schlauch Campaign Committee Information Technology Department at PPG Industries UPMC Cancer Centers and the University of Pittsburgh New York Mets Foundation, Inc. Lila I. Decker Kimberly Beth Schriver Susan Boyle Ingraham Dancu Associates, LLC Cancer Institute gratefully acknowledge the foundations that The Pittsburgh Foundation Roseann Stansbury DeGrazia Thomas W. Seaman Michael Boyle In-House Dental Services have provided support of $250 or more to further our mission. The Deno F. Barsotti Family Fund Robert A. DeMichiei Shaun J. Sears Richard Cohen J. E. Hartman Services The Broadhurst Family Fund Kimberly M. Derose Karen L. Shaffer Tom Flannery Jaeckle Fleischmann & Mugel, LLP Anonymous The Calihan Family Fund David E. Eibling Larry W. Shank Kimberly Fleming James Services Adriane R. Aul Foundation Nancy T. and William S. Conover II Fund Lori and Peter Ellis, MD Jeanne Siar Tom Grealish Kay Berry, Inc. Ayers Foundation The Gertrude E. Hellerman Charitable Trust Fund Alan H. Finegold Paul F. Sikora Barney Guttman Keystone Filler & Mfg. Co. Beckwith Family Foundation The Limbach Family Fund Kimberly Fleming Virginia G. Spang Ronald Herberman, MD Kids and A Cause Buffalo Bills Alumni Foundation Inc. Larry Potter Memorial Fund Devyn M. Gimiliano Patrick M. Stabile Sy Holzer Ladies Philoptochos Society Buncher Family Foundation Theresa L. Whiteside Nimick Fund Sean M. Girdwood J. Randall Staggers William Kassling of Holy Cross Greek Orthodox Church The Caliban Foundation Elsa U. Pardee Foundation Jack S. Goldsmith Susan L. Stepchuk Cary Klein LIA Agency, Inc. Grant Channell Memorial Fund Rauch Foundation Thomas B. Grealish Scott Stevens Barry Lembersky, MD Manheim Pittsburgh The Demakos Foundation The Rust Foundation Alan Kent Hodgdon, MD Kevin J. Stewart James Luketich, MD Meidensha Corporation Louise & Perry Dick Foundation Dee Dee Sacco Fight For Life Fund Judy Hodgson Carole J. Taylor and James J. Benedict Stanley Marks, MD Metplas, Inc. Mark Encin Foundation for Melanoma Research Juliet Lea Hillman Simonds Foundation Robert J. Howard Linda J. Thomson Leslie Merrill McCombs Michael P. Rade, MD, P.C. Nina Baldwin Fisher Foundation, Inc. G. Whitney Snyder Charitable Fund Leslie S. Hyde Gayle L. Tissue and Yiannis Kaloyeropoulos Mark E. Pasquerilla Newgate Capital Management LLC Lilah Hilliard Fisher Foundation, Inc. Stork Foundation Mark Vincent Incorvati Bonnie W. and Thomas L. VanKirk, Esq. Bonnie VanKirk Oak Glen Middle School Matthew Hillman Fisher Foundation The Sturges Foundation Samuel A. Jacobs, MD Dolores M. Vitvitsky Tom VanKirk Olympia Sports Attendant Medical Research Institute Pamela and Markos Tambakeras Family Foundation Jonas T. Johnson, MD Cynthia D. Warsing Debi Wheeler P & P Flooring LLC John F. Fortney Charitable Pancreatic Cancer The Tippins Foundation Sean Jay Jones Charles B. Watson III Harold W. Wheeler III PF Cook Brick Company, Inc. Research Group Winslow Foundation Jeffrey A. Kable Elizabeth A. Welch Theresa Whiteside Nimick, PhD R.I. Lampus, Co. Foster Charitable Foundation Samuel & Emma Winters Foundation Christopher J. Kairys Theresa Whiteside Nimick, PhD Respironics, Inc. Fountainhead Foundation Yates-Fund for Cancer Hope David F. Kapsha John J. Williamson Rewards Network Wayne Fusaro Pancreatic Cancer Research Fund Jennie Zoline Foundation Terry A. Wilson

Every gift to UPMC Cancer Centers and the University of Pittsburgh Cancer Institute plays a vital role in advancing research If we have made an error in any name or omitted and enhancing patient care. Unfortunately, space is too limited to list the individual names of donors that gave gifts at anyone from this list, please accept our apologies levels of $1 to $249. Please know your support is truly appreciated. and notify us at 412-623-4700.

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NEWS BRIEFS University of Pittsburgh Cancer Institute and Centre of UPMC Cancer Centers’ staff member awarded Integrated Oncology Cologne enter into partnership American Cancer Society’s Volunteer of the Year Award and Fighting Spirit Award In June 2008, the University of Pittsburgh Cancer Institute (UPCI) and the Centre of Integrated Oncology (CIO) at the University Hospital of Cologne and Marina Posvar, patient navigation services coordinator, Hillman Cancer Center, was the University Hospital of Bonn in Germany formed a strategic partnership awarded the American Cancer Society’s (ACS) 2007 Volunteer of the Year Award for to combine the strengths of both institutions to accelerate progress in cancer both the Greater Pittsburgh Unit and Pennsylvania Division, and in May 2008 also research, education, and patient care. received the Fighting Spirit Award.

The partnership will include the creation of a student exchange program, the The Volunteer of the Year Award recognizes outstanding achievements in volunteerism. development of collaborative research and joint clinical trials in selected areas, the The Fighting Sprit Award recognizes a cancer survivor who has been helped by the transfer of administrative and management advice, and the development of a common programs and services offered by the ACS and who has become involved as a international fundraising strategy for both clinical and translational research. dedicated volunteer with the ACS across both the Cancer Control programs and Income Development events. UPCI and the CIO will work to establish joint clinical trials focused initially on lung cancer, melanoma, and lymphatic malignancies. Collaborations in basic and pre-clinical Ms. Posvar first became involved with ACS when she was diagnosed with cancer and research will include cellular immunotherapy, allogeneic stem cell transplantation, attended their Look Good…Feel Better program. The program helped her through a and targeted therapies and biomarkers for patient selection and treatment response. difficult time, and she has given back to the ACS through her dedication to serving and supporting other cancer patients, and through her involvement in advocacy, fundraisers, committees, and community education events. UPMC Cancer Centers and UPCI receive awards Ms. Posvar has been a volunteer with ACS for four years. UPMC Cancer Centers and University of Pittsburgh Cancer Institute (UPCI) were Hillman Cancer Center also received the bronze Mission of Impact Award for recognized by two prestigious organizations — the American Cancer Society (ACS) Partners in Promotion: Hillman Cancer Center and the American Cancer Society, and the Leukemia & Lymphoma Society. honoring the relationship between the two organizations that was cultivated by the In 2006-2007, UPMC Cancer Centers and UPCI were awarded the American Cancer work of Ms. Posvar. Society’s Cancer Control Impact Award for Systems Initiatives, Pennsylvania Division, for their African American Cancer Care Partnership (AACCP) program that works to Pittsburgh Steelers team members reduce barriers to cancer care for African American patients. visit Hillman Cancer Center UPMC Cancer Centers and UPCI were also awarded the National Chairman’s Citation for Excellence in Community Service from the Leukemia & Lymphoma Society. UPMC Pittsburgh Steelers Max Starks and Ryan McBean visited patients and families at Cancer Centers and UPCI were nominated by the Pittsburgh Chapter of the society — Hillman Cancer Center in Shadyside, signing autographed team photos, posing for the only center to receive the yearly award out of more than 50 nominations. pictures, and sharing football anecdotes with patients. Staff from Hillman participated by giving patients cookies and holding a prize raffle. Patients were surprised and excited to spend the afternoon with the players. Panera Bread donates $57,000 to UPCI

On Jan. 30, Panera Bread presented University of Pittsburgh Cancer Institute and UPMC Cancer Centers with a check for $57,000 raised by their 2007 Operation Dough-Nation campaign.

Funding from this donation supports programs for Cancer Prevention and Population Sciences, including efforts to develop a registry of individuals who will be surveyed about health history and behavioral choices to develop a model of cancer prevention that will shed light on the factors that cause cancer. DISCOVERY & CARE photo courtesy of Pittsburgh Steelers/Danielle Hudak

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NONPROFIT ORG U.S. POSTAGE PAID PITTSBURGH, PA DISCOVERY & CARE PERMIT NO. 3834

A publication of UPMC Cancer Centers and the University of Pittsburgh Cancer Institute

UPMC Cancer Pavilion 5150 Centre Ave. Pittsburgh, PA 15232 1-800-533-UPMC (8762) www.UPMCCancerCenters.com

UPMC Cancer Centers offers cancer patients exceptional care and innovative treatments close to home. Working in tandem with the University of Pittsburgh Cancer Institute, western Pennsylvania’s only National Cancer Institute-designated Comprehensive Cancer Center, UPMC Cancer Centers provides the latest advances in cancer prevention, detection, diagnosis, and treatment at community-based locations throughout the region. The University of Pittsburgh Cancer Institute comprises the academic and research activities for cancer at the University of Pittsburgh and UPMC.

For information about supporting cancer research efforts and patient care at the University of Pittsburgh Cancer Institute and UPMC Cancer Centers, contact us at 412-623-4700.

UPMC Cancer Centers and University of Pittsburgh Cancer Institute

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