PTPRG,protein tyrosine phosphatase receptor type G polyclonal antibody

rotein tyrosine phosphatase receptor type G (PTPRG) is a member of the protein tyrosine phosphatase (PTP) family. or Research Use Only. Not for P FDiagnostic or Therapeutic Use. PTPs are known to be signaling molecules that regulate a variety Purchase does not include or carry of cellular processes including cell growth, differentiation, mitotic any right to resell or transfer this cycle, and oncogenic transformation. PTPRG possesses an product either as a stand-alone extracellular region, a single transmembrane region, and two product or as a component of another tandem intracytoplasmic catalytic domains, and thus represents product. Any use of this product other a receptor-type PTP. The extracellular region of this PTP contains than the permitted use without the a -like (CAH) domain, which is also found in express written authorization of Allele the extracellular region of PTPRBETA/ZETA. The PTPRG Biotech is strictly prohibited is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. In human breast, estradiol-17 Website: www.allelebiotech.com beta and zeranol regulate PTPRG expression and estrogenic Call: 1-800-991-RNAi/858-587-6645 down-regulation of PTPRG is associated with estrogen receptor (Pacific Time: 9:00AM~5:00PM) alpha expression. However, epithelial-stromal cell interaction is Email: [email protected] also important in regulation of PTPRG expression by estrogenically active agents. Buffers Box 1 | Basic Info Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column Cat. No. ABP-PAB-11042 and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS. Animal ID RB0553-0554 Immunogen Host Rabbit KLH conjugated synthetic peptide comprised of amino acids 765 Reactivity Human - 782 [CNKIKSKGFPRRFREVPS] of the human protein tyrosine Purified Format phosphatase receptor type G (PTPRG) protein. Accession number NM_002841 Application: Amount 100 µg Tested by peptide-specific ELISA (1:1,000). Alternative Name(s): HPTPG, RPTPG, R-PTP-GAMMA, PTP-gamma, protein Storage tyrosine phosphatase gamma, receptor Maintain refrigerated at 2-8°C for up to 6 months. For long term tyrosine phosphatase gamma, receptor- storage store ar -20°C. Avoid repeated freeze-thaw cycles. type protein phosphatase gamma, protein tyrosine phosphatase, receptor type, gamma polypeptide References:

1. Liu S, Sugimoto Y, Kulp SK, Jiang J, Chang HL, Park KY, Kashida Y, Lin YC: Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. Anticancer Res. 22(6C): 3917-3923 (2002). 2. Liu S, Kulp SK, Sugimoto Y, Jiang J, Chang HL, Lin YC: Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents. Breast Cancer Res. Treat. 71(1): 21-35 (2002). 3. Kastury K, Ohta M, Lasota J, Moir D, Dorman T, LaForgia S, Druck T, Huebner K: Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) translocation. Genomics 32(2): 225-235 (1996). 4. Barnea G, Silvennoinen O, Shaanan B, Honegger AM, Canoll PD, D’Eustachio P, Morse B, Levy JB, Laforgia S, Huebner K, et al.: Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases. Mol. Cell. Biol. 13(3): 1497-1506 (1993). 5. Krueger NX, Streuli M, Saito H: Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 9(10): 3241- 3252 (1990). 6. LaForgia S, Morse B, Levy J, Barnea G, Cannizzaro LA, Li F, Nowell PC, Boghosian-Sell L, Glick J, Weston A, et al.: Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. Proc. Natl. Acad. Sci. U S A. 88(11): 5036- 5040 (1991).

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