Performance Report 2011
Department of Pathophysiology & Allergy Research
Center of Pathophysiology, Infectiology and Immunology
Medical University Vienna
Coordinated by:
Marion Sack
Content Page
Introduction 2
Organigram 7
Personnel 10
1. Detailed Reports of Divisions 11
1.1 Division for Comparative Immunology and Oncology 11
1.2. Division for Cellular and Molecular Pathophysiology 31
1.3 Division for Immunopathology 51
1.4 Division for Medical Biotechnology 72
1 Performance Report 2011 Introduction
Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world.
Louis Pasteur
If we are to develop effective therapeutic strategies to combat physiological disorders, it is important to understand the pathophysiology of disease. The Institute of Pathophysiology and Allergy Research (IPA) has a history of outstanding research, both basic and translational, in cellular and molecular pathophysiology, immunopathology, comparative immunology, oncology, medical biotechnology and allergology.
The year 2011 was particularly successful for the IPA: in total, 21 independent groups performed competitive research in different aspects of the abovementioned fields. Their excellent results are reflected in their numerous scientific publications in peer-reviewed high- impact journals, in 34 research awards, and in their many contributions to prestigious scientific meetings. Alongside these successes, IPA members have continued or initiated new collaborative scientific work, both nationally and internationally. Several research projects funded by the Austrian Science Fund (FWF) and other funding agencies, e.g. the Österreichische Nationalbank or the medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien, were granted to principal investigators at the IPA.
Over the years, the IPA’s work has gained an excellent international reputation. Figure 1 shows an overview of the total sum of the IPA’s impact factors for the period 2004-2011.
Figure 1
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total impact factors of IPA of factors impact total 100
0 2004 2005 2006 2007 2008 2009 2010 2011
In addition to its outstanding scientific performance, the IPA has also delivered education of an exceptionally high quality to medical students. The total numbers of semester hours held at the Medical University from 2004-2011 are illustrated in Figure 2; they reflect the IPA’s members’ ongoing commitment to teaching.
2 Performance Report 2011 Introduction
Figure 2
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sum of semester hours semester of sum 50
0 2004 2005 2006 2007 2008 2009 2010 2011
Academic teaching of the next generation of scientists is an important IPA focus, and is demonstrated by the training of a high number of bachelor’s, diploma and PhD students. In 2011, a total of 110 young researchers were educated at the IPA. Figure 3 shows the numbers of diploma (red bars) and PhD (yellow bars) students. And for the first time in 2011, bachelor students (blue bar) were also supervised at the IPA.
Figure 3
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20 number of students of number 10
0 2004 2005 2006 2007 2008 2009 2010 2011
The increasing numbers of diploma and PhD theses supervised at the IPA reflects the importance of education at our institute. The participation of several of our members in very competitive international doctoral programs funded by the FWF attracts outstanding, highly motivated national and international students to the IPA. All students have the opportunity to learn a great variety of state-of-the-art laboratory techniques in their research specializations. Beyond that, they gain insights into the broad spectrum of research activities at the IPA. This is accelerated by the “Impulse Seminars” organized by the IPA at regular intervals. These seminars are also regarded as advanced training for medical doctors both within the IPA and outside it.
3 Performance Report 2011 Introduction
The IPA is also active in training physicians for specializations in pathophysiology and immunology. Furthermore, members of the IPA are active in teaching and examining not only at the Medical University but at other universities, too, including universities of applied sciences. Several IPA members also act as reviewers of external diploma and PhD theses, Habilitations, scientific manuscripts, and research grants, and are active on editorial and advisory boards and on the boards of national and international research societies.
Apart from the IPA’s exceptional achievements in research and education, several highlights of the year 2011 should be mentioned: one was the successful completion of the Sonderforschungsbereich (SFB) F18 “Molecular and immunological strategies for prevention, diagnosis and treatment of Type I allergies” coordinated by Univ. Prof. Dr. Rudolf Valenta. This SFB program had been financed by the Austrian Science Fund (FWF) for the maximum funding period of 12 years. Several group leaders of the IPA (Barbara Bohle, Heimo Breiteneder, Erika Jensen-Jarolim, Rudolf Valenta, Susanne Vrtala) were members of this excellent research programme. The completion of SFB-F18 was followed by the successful implementation of a new FWF-funded SFB-F46 programme, “Towards prevention and therapy of allergy”, coordinated by Univ. Prof. Dr. Rudolf Valenta. Again, several group leaders of the IPA (Barbara Bohle, Heimo Breiteneder, Sabine Flicker, Karin Hoffmann- Sommergruber, Erika Jensen-Jarolim, Rudolf Valenta, Susanne Vrtala) are part of this highly competitive, multidisciplinary research programme. Another highlight in 2011 was the start of Ass. Prof. Dr. Enikö Kallay as manager of the EU-7RP people 2010 ITN-project “The role of the Calcium Sensing Receptor in health and disease, implications for translational medicine”. Enikö Kallay coordinates a consortium consisting of 7 international academic partners and 3 industrial partners. This EU project will last for 4 years and will investigate various aspects of the Calcium Sensing Receptor´s biochemistry, physiology and pathophysiology.
Two further highlights in 2011 were the appointment of Heimo Breiteneder as University Professor for Medical Biotechnology in May, and in August, that of Erika Jensen- Jarolim as University Professor for Comparative Medicine, a joint position at the Messerli Research Institute of the Veterinary University of Vienna, the Medical University of Vienna and the University Vienna. To fully focus on her new challenges and duties, Univ. Prof. Erika Jensen- Jarolim stepped down from the position as head of the IPA. Prof. Peter Pietschmann temporary headed the IPA until 1.12.2012, when I became the new head. At the same time, the Division of Experimental Allergology was founded.
4 Performance Report 2011 Introduction
I wish to express my sincere thanks to all who have contributed to the very high quality of the IPA’s scientific and teaching work. Additionally, I would like to acknowledge all those members of the IPA who have contributed to our success by their ongoing efforts and support in administrative, organizational, and financial matters, as well as the cleaning staff and those taking care of the animal facility. Their tremendous backup has significantly contributed to the high performance of the IPA in research and education.
Special thanks to
the Institutsreferentin Marion Sack, the team in the Leitstelle
Marion Krones Julia Krüger Andreas Kunrath
…and the facility team!
Katharina Reinberger Andrea Vlasaty Brigitte Schwarz
5 Performance Report 2011 Introduction
I am convinced that the unstinting engagement of all members of the IPA will guarantee the Institute’s continuing success in delivering an outstanding quality of basic and translational research and education. Our strong team spirit is reflected in the IPA’s motto for the future: “Succeeding together”.
Barbara Bohle
6 Performance Report 2011 Organigram
Organigramm (December 2011)
Head: Barbara Bohle, PhD, Professor for Cellular Allergology Deputy Head: Peter Pietschmann, MD, Assoc. Professor
Department Secretary: Marion Sack Check point: Andreas Kunrath Student Secretary: Marion Krones, Julia Krüger Division for Comparative Immunology and Oncology
Head: Erika Jensen-Jarolim, MD, Professor for Pathophysiology, Professor for Comparative Medicine Secretary: Nora Diallo , substituted by Katica Josipovic Erika Bajna, CTA, 50% WG AllergoOncology: Head: Erika Jensen-Jarolim, MD, Professor Beatrix Pfanzagl, Ass. Professor Josef Singer, PhD-Student Krisztina Szalai, PhD Durga Krishnamurthy, PhD-Student Franziska Roth-Walter, PhD Kathrin Thell, Diploma Student Philipp Starkl, PhD Janis Kinkel, Diploma Student Marlene Weichselbaumer, PhD Ferdinand Felix, Diploma Student Anna Lukschal, PhD-Student Anna Willensdorfer, CTA Caroline Stremnitzer, PhD-Student Miroslawa Matz, Tech. Ass. WG Tumor Pathology: Head: Enikö Kallay, PhD, Ass. Professor Giovanna Bises, PhD Samawansha Tennakoon, PhD-Student Julia Höbaus, PhD-Student Abhishek Aggarwal, PhD-Student Doris Hummel, PhD-Student Teresa Manhardt, CTA Ursula Thiem, PhD-Student Maria Elena Manfredini, Project manager Irfete Fetahu, PhD-Student WG Gastrointestinal Immunology: Head: Eva Untersmayr-Elsenhuber, MD, Priv.-Doz. Susanne Diesner, MD Kristina Kreiner, Diploma Student Vera Elisabeth Assmann, Diploma Student Cornelia Schultz, BMA WG Nutritional Immunology: Head: Isabella Pali-Schöll, PhD, Priv.-Doz. Helen Szöllösi, Diploma Student WG Molecular System Biology and Pathophysiology Head: Diana Mechtcheriakova, PhD, Priv.-Doz. Martin Svoboda, PhD Tamara Kaufmann, Diploma Student Anastasia Meshcheryakova, PhD-Student
Division for Cellular and Molecular Pathophysiology
Head: Peter Pietschmann, MD, Assoc. Professor Secretary: Birgit Schwarz Erika Bajna, CTA, 50% WG Bone, Cartilage and conn. Tissue Research: Head: Peter Pietschmann, MD, Assoc. Professor Ursula Föger-Samwald, MSci Helene Mayr, Diploma Student Ursula Semrad-Azizi, PhD- Student Sena Mukaddam, Diploma Student Eduardo Maldonado-Gonzalez, PhD-Student Nadine Ortner, Diploma Student Julian Diebler, Diploma Student Josef Sillipp, Diploma Student Michael Kurz, Diploma Student Andrea Kapfenberger, CTA
7 Performance Report 2011 Organigram
WG Cell Biology: Head: Renate Fuchs, PhD, Assoc. Professor Leszek Gajdzik, Technician Thomas Spanberger, Diploma Student Manuel Jalali, Diploma Student WG Pathophysioloy of the Placenta: Head: Isabella Ellinger, PhD, Assoc, Professor Andreas Heindl, PhD-Student Hana Uhrova, BMA WG Cellular Pathology and Pharmacokinetics: Head: Theresia Thalhammer, PhD, Assoc. Professor Erdentetsetseg Rentsen, PhD-Student Johann Gründsteidl, Diploma Student Juliane Riha, PhD-Student Dilek Kalayci, Diploma Student Madonna Awad, Diploma Student Leonard Ndue, Diploma Student Kathrin Burger, Diploma Student Sultan Sirag, Diploma Student Yasemin Durmaz, Diploma Student Wenyi Zhang, Diploma Student
Division for Immunopathology
Head: Rudolf Valenta, MD, Professor for Allergology Secretary: Doris Werjant Editorial Secretary: Sanna Lippert SFB-Secretary: Anna Guentcheva WG Molecular Immunopathology: Head: Rudolf Valenta, MD, Professor Birgit Linhart, PhD Eva Wollmann, PhD-Student Christian Lupinek, MD Kuan Wei-Chen, PhD-Student Raffaela Campana, PhD Bharani Srinivasan, PhD-Student Katarzyna Niespodziana, PhD Isabella Breyer, Diploma-Student Mirela Curin, PhD, Mareike Appel, Diploma-Student Julia Eckl-Dorna, MD, PhD Marina Schuschnig, Diploma-Student Tetiana Garmatiuk, MD Sandra Gutfreund, Diploma-Student Daniela Gallerano, PhD-Student Hannes Mayerhofer, Diploma-Student Clarissa Cabauattan, PhD-Student Milena Weber, CTA Meena Narayanan, PhD-Student Renata Kiss, CTA WG Immunotechnology: Head: Susanne Vrtala, PhD, Ass. Professor Irene Mittermann, PhD Srinita Banerjee, PhD-Student Alexandra Schmidhuber, PhD-Student Yvonne Resch, PhD-Student Sandra Pahr, PhD-Student WG Immunochemistry: Head: Margarete Focke-Tejkl, PhD, Univ.-Doz. Katharina Marth, MD Verena Hameter, Diploma-Student WG Immune Recognition: Head: Ines Swoboda, PhD, Univ.-Doz. Teresa Twaroch, PhD-Student WG Antibody Research Head: Sabine Flicker, PhD, Priv.-Doz. Elisabeth Gadermaier, PhD-Student Christoph Madritsch, PhD-Student
8 Performance Report 2011 Organigram
Division for Medical Biotechnology
Head: Heimo Breiteneder, PhD, Professor for Medical Biotechnology Secretary: Carina Baderer WG Biotechnology & Biochemical Diagnostics: Head: Heimo Breiteneder, PhD, Professor Merima Bublin, PhD Daniele Pucciarelli, PhD-Student Christine Hafner, MD Maria Kostadinova, PhD-Student Ursula Smole, PhD Daniela Ackerbauer, Diploma Student Barbara Gepp, PhD-Student Nina Lengger, BMA WG Molecular Allergology: Head: Karin Hoffmann-Sommergruber, PhD, Ass. Professor Christiane Agreiter, Diploma Student Magdolna Vermes, ARat Maria Berneder, Diploma Student Gerlinde Hofstetter, BMA WG Experimental Immunobiology: Head: Stefan Wagner, PhD, Ass. Professor Kazem Ashjaei, PhD-Student WG Biochemistry and Bioinformatics: Head: Christian Radauer, PhD, Priv.-Doz. Eva Gushl, PhD-Student WG Molecular Research in Traditional Chinese Medicine: Head: Yan Ma, PhD, Priv.-Doz. Administration TCM: Linda Lam Karoline Peter, PhD-Student Kristina Marchart, Diploma Student
Division for Experimental Allergology
Head: Barbara Bohle, PhD, Professor for Cellular Allergology Secretary: Dorothea Angelides CD-Laboratory Secretary: Bana Haddad Birgit Nagl, BMA WG Allergy Research: Head: Barbara Bohle, PhD Claudia Kitzmüller, PhD Julia Kalser, Diploma-Student Stephan Deifl, PhD-Student Christian Walterskirchen, Diploma-Student Brinda Subbarayal, PhD-Student Christian Zwicker, Diploma Student Nora Zulehner, PhD-Student Sandra Heizer, BMA Dagmar Kollmann, Diploma Student WG Cellular Allergology: Head: Beatrice Jahn-Schmid, PhD, Priv.-Doz. Dries van Hemelen, PhD-Student
Facility Services and Animal Keeping:
Katharina Reinberger Brigitte Schwarz Andrea Vlasaty
9 Performance Report 2011 Personnel
a) Personnel of IPA (between January and December 2011)1
Personnel (p.) 01.01.2011 31.12.2011 MUW total female total female Univ.Prof. (full professors) RV, EJJ, BB 3.00 2.00 RV, EJJ, BB, HB 4.00 2.00 Ao.Univ.Prof (Assoc.Prof) HB, IE, RF, PP, 5.00 3.00 IE, RF, PP, TT 4.00 3.00 TT Univ./Priv.Doz. (Assoc.Prof) EUE, BJS 2.00 2.00 2.00 2.00 Assistant professors BP,KHS,EK,SV, 5.00 4.00 5.00 4.00 SW Univ.Assistants BL, CR, YM 3.00 2.00 3.00 2.00 Technical personnel NB,LG,TM,MM, 9.00 8.00 9.00 8.00 MV,AK,BN,MW, EB Administrative personnel CB,MS,ND,BS, 6.50 5.50 CB,MS,KJ,MK½, 7.50 6.50 AK,DW,BS½ JK½,AK, DW,DA,BS½ Supportive personnel AV, KR, BS 3.00 3.00 3.00 3.00 36.50 29.50 37.50 30.50 Third party funded p. Scientific personnel Univ.Doz. 5.00 5.00 Univ.Doz. 4.00 4.00 (Assoc.Prof) (Assoc.Prof) MFT, IS, SF, DM, MFT, SF, DM, IP IP PostDoc 14.00 12.00 17.00 14.00 Doctoral students2 37.00 28.00 34.00 26.00 Technical personnel BMA 3.00 3.00 5.00 5.00 CTA 3.00 3.00 2.00 2.00 Administrative personnel MM, BH,SL 3.00 3.00 AG, BH, SL 3.00 3.00 Project employees MS, LL 0.30 0.30 MS, MEM, UFS 1.25 1.25 Diploma students (FB3) 9.00 6.00 10.00 7.00 74.30 60.30 76.25 62.25
Other scientific Doctoral students 4.00 3.00 6.00 4.00 coworkers Diploma students 10.00 7.00 15.00 6.00 Student 2.00 1.00 2.00 1.00 apprentices 16.00 11.00 23.00 11.00 MUW personnel total 126.80 100.80 136.75 103.75
At the end of 2011 27,4% of the entire personnel was MUV-paid personnel. Of all IPA-employees 75,9% were female.
1 in full time equivalents “FTE” 40 h = 1 FTE 2 due to novel rules by FWF PhD students are employed 75 % FTE to be able to spend time for education 3 FB: Forschungsbeihilfe: defined financial support 10 Performance Report 2011 Comparative Immunology and Oncology
1. Detailed Reports of Divisions
1.1 Division for Comparative Immunology and Oncology Head: Erika Jensen-Jarolim, MD, Professor
1. Publications4 IF Number Top/Std/Subst Erika Jensen-Jarolim 19.117 7 2x Top,3x St,2x SSt Enikö Kállay 6.964 2 2x St Isabella Pali-Schoell 6.297 1 1x Top Eva Untersmayr-E. 0 1 1x SSt Diana Mechtcheriakova 4.411 1 1x St Sum 26.061 12 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2
2. Supervision of bachelor, diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Erika Jensen-Jarolim - 3 8 Enikö Kállay - - 7 Isabella Pali-Schoell 1 - - Eva Untersmayr-E. - 3 2 Diana Mechtcheriakova - 1 1 Sum 1 7 18
3. Teaching SS* WS* total W+S oral Exams Erika Jensen-Jarolim 2.16 6.00 8.16 - Enikö Kállay 7.00 8.98 15.98 - Isabella Pali-Schoell 2.05 1.22 3.27 - Eva Untersmayr-E. 0.00 6.35 6.35 2 Diana Mechtcheriakova 1.41 2.42 3.83 - Sum 12.62 24.97 37.59 2
4 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 11 Performance Report 2011 Comparative Immunology and Oncology
1.1.1. Publications a) Peer-reviewed original articles : n = 6
Nr. Article IF Class 1. M., Weichselbaumer, M. Willmann, M. Reifinger, J. Singer, E. n.d. St. Bajna, Y. Sobanov, D. Mechtcheriakova, E. Selzer, J. G. Thalhammer, R. Kammerer, E.* Jensen-Jarolim. Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact comparative oncology studies. PLOS Currents, 2011 Mar 16;3:RRN1223. 3. C., Nemeth, S. Humpeler, E. Kallay, I. Mesteri, M. Svoboda, 2.825 St. O. Rögelsperger, N. Klammer , T. Thalhammer, C. Ekmekcioglu. Decreased expression of the melatonin receptor 1 in human colorectal adenocarcinomas. J Biol Regul Homeost Agents. 2011 Oct-Dec;25(4):531-42. 4. A., Lukschal, J. Fuhrmann, J. Sobanov, D. Neumann, J. n.d. - Wallmann, R. Knittelfelder, W. Hemmer, O. Scheiner, M. Vogel, B. M. Stadler, E. Jensen-Jarolim and K. Szalai. Anti-idiotypic Fab fragments image a conserved N-terminal epitope patch of grass pollen allergen Phl p 1.The Open Allergy Journal, [DOI: 10.2174/1874838401104010016] 5. P., Starkl, D. Krishnamurthy, O. Hantschel, F. Felix, D. n.d. - Oberthuer, H. A. Sampson, T. Schweighoffer, I. Swoboda, C. Betzel, G. S. Superti-Furga, E. Untersmayr, E. Jensen- Jarolim. Heating influences the structure, intestinal epithelial binding, signaling and immunogenicity of the major peanut allergen Ara h 2. Open Allergy Journal. [DOI: 10.2174/1874838401104010024]. 6. D., Mechtcheriakova, Y. Sobanov, G. Holtappels, E. Bajna, 4.411 St. M. Svoboda, M. Jaritz, C. Bachert, E. Jensen-Jarolim (2011) Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component. PLoS One 6: e25611. 10.1371/journal.pone.0025611 [doi];PONE-D-11-10751 [pii]. sum 7.236 b) Invited Articles & Reviews with IF: n = 4
Nr. Article IF Class 1. E., Jensen-Jarolim, J. Singer, Cancer Vaccines inducing 4.214 St. antibody production: More Pros than Cons, Exp. Rev. of Vaccines 10 (9), 1281-1289, 2011 2. E., Jensen-Jarolim, J. Singer, Why could passive IgE 4.195 Top antibody therapy be safe in clinical oncology? Clin Exp Allergy. 2011 May 5. doi: 10.1111/j.1365-2222.2011.03764.x 3. I., Pali-Schöll, E. Jensen-Jarolim, Anti-acid medication as a 6.297 Top risk factor for food allergy. Review. Allergy, 2011; 66:469-477 4. H. S., Cross, T. Nittke, E. Kallay Colonic vitamin D 4,119 St. metabolism: implications for the pathogenesis of inflammatory bowel disease and colorectal cancer., Mol Cell Endocrinol. 2011 Dec 5;347(1-2):70-9. Epub 2011 Jul 27 sum 18.825
12 Performance Report 2011 Comparative Immunology and Oncology c) Invited Articles & Reviews without IF: n = 0 d) Book contributions: n = 0 e) Abstracts, printed in periodicals: n = 1
1. Smole U., D. Mechtcheriakova, Y. Sobanov, C. Radauer, N. Balazs, M. Bublin, S. Wagner, K. Hoffmann-Sommergruber, E. Jensen-Jarolim, and H. Breiteneder. 2010. The major birch pollen allergen, Bet v 1.0101, is sufficient to induce a Th2-promoting phenotype in monocyte-derived dendritic cells of birch pollen allergic donors. 29th Congress of the European Academy of Allergy and Clinical Immunology –London 2010; Allergy 2010;65 (Suppl. 92):12 f) Abstracts, in congress proceedings or abstract books and posters: n = 65
1. Diesner SC, Untersmayr E, Oostingh GJ, Selzle K, Pfaller T, Schultz C, Zhang Y, Krishnamurthy D, Starkl P, Knittelfelder R, Förster-Waldl E, Pollak A, Scheiner O, Pöschl U, Jensen-Jarolim E, Duschl A. Nitration of ovalbumin decreases the risk for sensitization via the oral route in a mouse food allergy model. Food Allergy and Anaphylaxis Meeting, (Feb 17-19, 2011, Venice, Italy, oral presentation) 2. Starkl P, Krishnamurthy D, Szalai K, Felix F, Lukschal A, Oberthuer D, Sampson HA, Swoboda I, Betzel C, Untersmayr E and Jensen-Jarolim E. Heating influences the structure of the major peanut allergen Ara h 2 and increases its intestinal epithelial adsorption and immunogenicity, Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, 2011 3. Pali-Schöll I, Szöllösi H, Scheicher B, Stremnitzer C, Starkl P, Zimmer A, Jensen- Jarolim E. Protamine-based nanoparticles with CpG-oligodesoxynucleotides are suitable for the induction of a Th1-mediated immune response. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011 4. Roth-Walter F, Starkl P, Zuberbier T, Brunner R, Pali-Schöll I, Kinkel J, Felix F, Jensen-Jarolim E, Kinaciyan T. Naturally occurring glutathione expose linear ovomucoid IgE-epitopes relevant in persistent egg allergy. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011 5. Stremnitzer C, Szalai K, Starkl P, Lukschal A, Willensdorfer A, Mildner M, Tschachler E, Reichart U, Brandner JM, Knapp S, Jensen-Jarolim E. The molecular requirements of house dust mite allergens Der p 1 and Der p 2 to induce allergic skin inflammation. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011 6. Krishnamurthy D, Lukschal A, Starkl P, Diesner SC, Pali I, Untersmayr E, Jensen- Jarolim E. Anti-acid medications increase the risk of food allergy to orally applied milk allergen casein in a BALB/c mouse model, Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011 7. Diesner SC, Schultz C, Wang X-Y, Ratzinger G, Starkl P, Assmann V, Kreiner K, Roth-Walter F, Pali-Schöll I, Jensen-Jarolim E, Gabor F, Untersmayr E. Allergen- loaded microparticles functionalized with the M-Cell targeting substance neuraminidase as novel oral immunotherapy of allergy. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011 8. Diesner SC, Olivera A, Dillahunt S, Schultz C, Watzlawek T, Förster-Waldl E, Pollak A, Jensen-Jarolim E, Untersmayr E , Rivera J. Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a murine food allergy model. Annual Meeting of
13 Performance Report 2011 Comparative Immunology and Oncology
the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15- 17, 2011 9. Krishnamurthy D, Starkl P, Szalai K, Roth-Walter F, Mannhalter C, Diesner SC, Untersmayr E , Jensen-Jarolim E. Monitoring neutrophils and platelets participatation during casein-induced anaphylaxis in an experimental BALB/c mouse model. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011 10. Singer J, Szalai K, Thell K, Willensdorfer A, Stremnitzer C, Szöllösi H, Michaelis U, Weghofer M, Ritter M, Jensen-Jarolim E. Evaluation of anti-tumor vaccines using Adeno-associated virus like particles (AAVLP) as carrier for HER-2 mimotopes. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, 2011 11. Thell K, Szalai K, Singer J, Ritter M, Pfanzagl B, Willensdorfer A, Stremnitzer C, Michaelis U, Jensen-Jarolim E. New carriers for B-cell vaccines: Immunogenicity and safety aspects of Adeno-associated virus-like particles: new carriers for B-Cell vaccines (AAVLPs). Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011 12. Roth-Walter F, Starkl P, Zuberbier T, Brunner R, Pali-Schöll I, Kinkel J, Felix F, Jensen-Jarolim E, Kinaciyan T. Glutathione in egg exposes linear ovomucoid IGE- Epitopes relevant in persistent egg allergy. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011 13. Svoboda M, Sobanov Y, Holtappels G, Bajna E, Jaritz M, Bachert C, Jensen-Jarolim E, Mechtcheriakova D. Activation-induced cytidine deaminase (AID) in inflammatory process: multigene signature approach to delineate the role of AID-driven events. Annual Meeting of the Austrian Society of Allergy and Clinical Immunology, Graz, Austria, September 15-17, 2011 14. Svoboda M., Kaufmann T., Meshcheryakova A., Bajna E., Jensen-Jarolim E., Mechtcheriakova D. Activation-induced cytidine deaminase (AID) at the crosstalk between immunity and cancer: multigene signature approach to assess role of aid in tumorigenicity and pluripotency of epithelial cells. Annual Symposium 2011 Verein zur Förderung von Wissenschaft und Forschung in den neuen Wiener Universitätskliniken am Allgemeinen Krankenhaus der STADT WIEN; Vienna, Austria 15. Svoboda M., Kaufmann T., Meshcheryakova A., Bajna E., Mechtcheriakova D. Activation-induced cytidine deaminase (AID) from immunity to cancer: Does AID facilitate tumorigenesis and/or pluripotency of epithelial cells? Annual Meeting OEGAI 2011, Graz, Austria (oral presentation) 16. Svoboda M., Sobanov Y., Holtappels G., Bajna E., Jaritz M., Bachert C., Jensen- Jarolim E., Mechtcheriakova D. Activation-induced cytidine deaminase (AID) in inflammatory process. Joint Annual Meeting DGfI and SIICA 2011, Riccione, Italy 17. Jensen-Jarolim E, Singer J, Weichselbaumer M, Willmann M, Thalhammer J, Comparative medicine to speed up drug development, zur 45 Annual Meeting of the Austrian Society of Tropical Medicine and Parasitology, Vienna, Austria, November 17-19, 2011 18. Stremnitzer C, Szalai K, Starkl P, Lukschal A, Willensdorfer A, Mildner M, Tschachler E, Reichart U, Brandner JM, Knapp S, Jensen-Jarolim E. The molecular requirements of house dust mite allergens Der p 1 and Der p 2 to induce allergic skin inflammation. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 19. Diesner SC, Schultz C, Krishnamurthy D, Assmann V, Kreiner K, Weichselbaumer M, Starkl P, Pollak A, Jensen-Jarolim E, Pali-Schöll I, Untersmayr E. Anaphylactic Reponses in an oral OVA food allergy model under acid-suppression in BALB/c mice
14 Performance Report 2011 Comparative Immunology and Oncology
are based on IgE rather than IgG1 antibodies. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, 2011 20. Starkl P, Krishnamurthy D, Szalai K, Felix F, Lukschal A, Oberthuer D, Sampson HA, Swoboda I, Betzel C, Untersmayr E and Jensen-Jarolim E. Heating influences the structure of the major peanut allergen Ara h 2 and increases its intestinal epithelial adsorption and immunogenicity, Retreat of the Center of Pathophysiology, Infectiology and Immunology, Austria, 2011 21. Roth-Walter F, Starkl P, Zuberbier T, Brunner R, Pali-Schöll I, Kinkel J, Felix F, Jensen-Jarolim E, Kinaciyan T. Glutathione in egg exposes linear ovomucoid IgE- Epitopes relevant in persistent egg allergy. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Graz, Austria, September 15-17, 2011 22. Diesner SC, Olivera A, Dillahunt S, Schultz C, Watzlawek T, Förster-Waldl E, Pollak A, Jensen-Jarolim E, Untersmayr E, Rivera J. Sphingosine 1 phosphate homeostasis influences intestinal allergen uptake and oral sensitization in a mouse food allergy model. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 23. Diesner SC, Schultz C, Wang X-Y, Ratzinger G, Starkl P, Assmann V, Kreiner K, Roth-Walter F, Pali-Schöll I, Jensen-Jarolim E, Gabor F, Untersmayr E. Allergen- loaded microparticles functionalized with the M-Cell targeting substance neuraminidase as novel oral immunotherapy of allergy. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 24. Pali-Schöll I, Szöllösi H, Scheicher B, Starkl P, Stremnitzer C, Zimmer A, Jensen- Jarolim E. Protamine-based nanoparticles in conjunction with CpG ODN are useful tools to induce an allergen-specific TH1-response in BALB/c-mice. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 25. Lukschal A, Mari A, Harwanegg C, Wallmann J, Palazzo P, Liso M, Pali I, Jensen- Jarolim E. Evaluation of prevalence of IgE IgG4 and IgG reactivity to Phl/p/5 protein and its mimotope H32 in a large population of allergic patients. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 26. Thell K, Szalai K, Singer J, Ritter M, Pfanzagl B, Willensdorfer A, Stremnitzer C, Michaelis U, Jensen-Jarolim E. Immunogenicity and safety aspects of Adeno- Associated virus-like particles: new carriers for B-Cell vaccines, Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 27. Singer J, Szalai K, Thell K, Willensdorfer A, Stremnitzer C, Szöllösi H, Michaelis U, Weghofer M, Ritter M, Jensen-Jarolim E. Evaluation of Adeno-Associated Virus Like Particles (AAVLP) as carriers for HER-2 mimotope cancer vaccines. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 28. Krishnamurthy D, Lukschal A, Starkl P, Diesner SC, Pali I, Untersmayr E, Jensen- Jarolim E. Anti-acid medications increase the risk for milk allergy in a mouse model. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 29. Roth-Walter F, Starkl P, ZuberbierT, Brunner R, Pali-Schöll I, Kinkel J, Felix F, Jensen-Jarolim E, Kinaciyan T. Glutathione exposed sequential epitopes of ovomucoid are relevant for persistent egg-allergic patients. XXII. World Allergy Congress, December 4-8, Cancun, Mexico, 2011 30. Diesner SC, Schultz C, Wang X, Ratzinger G, Starkl P, Assmann V, Kreiner K, Roth- Walter F, Pali I, Jensen-Jarolim E, Gabor F, Untersmayr E. M-cell targeting by neuraminidase functionalized microparticles for future application in oral immunotherapy. XXII. World Allergy Congress, Cancun, Mexico, December 4-8, 2011.
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31. Smole U, Balazs N, Radauer C, Sobanov Y, Bublin M, Gaier S, Hoffmann- Sommergruber K, Jensen-Jarolim E, Mechtcheriakova D, Breiteneder H. Specific recognition of the major birch pollen allergen Bet v 1 programs dendritic cells to induce either Th2 or tolerogenic responses. XXII. World Allergy Congress, Cancun, Mexico, December 4-8, 2011 32. Smole U., N. Balazs, Y. Sobanov, C. Radauer, M. Bublin, K. Hoffmann- Sommergruber, E. Jensen-Jarolim, D. Mechtcheriakova and Heimo Breiteneder. 2011. Lipid raft mediated uptake of the major birch pollen allergen Bet v 1.0101 activates Th2-polarizing signaling pathways in dendritic cells of allergic donors. 30th Congress of the European Academy of Allergy and Clinical Immunology – Istanbul 2011 (oral presentation) 33. Jensen-Jarolim E, Szalai K, Thell K, Singer J, Ritter M, Pfanzagl B, Willensdorfer A, Stremnitzer C, Michaelis U. Immunogenicity and safety aspects of adeno-associated virus–like particles (AAVLPs) as carriers for B-cell vaccines. XXII. World Allergy Congress, Cancun, Mexico, December 4-8, 2011. 34. Singer J, Plum M, Braren I, Karagiannis P, Mechtcheriakova D, Knittelfelder R, Spillner E, Jensen-Jarolim E. Comparing antibody mediated-cytotoxicity and - phagocytosis of anti-EGFR IgG and IgE antibodies in a flow cytometric assay. 9th EAACI- GA²LEN Immunology Winter School, Basic Immunology Research in Allergy, Davos, Switzerland, February 3-6, 2011. 35. Weichselbaumer M, Singer J, Stockner T, Mechtcheriakova D, Sobanov Y, Bajna E, Wrba F, Horvat R, Thalhammer JG, Willmann M, Jensen-Jarolim E. ErbB-1 and ErbB- 2 expression in canine mammary cancer and their role as targets in comparative oncology. Second AACR International Conference on Frontiers in Basic Cancer Research, San Francisco, CA, September 14-18, 2011. 36. Weichselbaumer M, Willmann M, Reifinger M, Singer J, Bajna E, Sobanov Y, Mechteriakova D, Selzer E, Thalhammer JG, Kammerer R, Jensen-Jarolim E. Comparative analysis of the target of anti-human carcinoembryonic antigen (CEA) antibody Col-1 and CEA receptor (CEAR) in canine and human mammary cancer. ESVONC Annual Congress of the European Society of Veterinary Oncology, Glasgow, Scotland, March 24-26, 2011 37. Petricevic B, Längle J, Singer J, Steger G, Jensen-Jarolim E, Bergmann M. Evaluation of trastuzumab mediated antibody dependent cytotoxicity in metastatic breast cancer patient using a rapid FACS-based analysis. ACO/ASSO Meeting by the Austrian Society of Oncologic Surgery, St. Wolfgang/OÖ, October 15, 2011. 38. Weichselbaumer M, Braun A, Aleksic D, Blaschke L, Zimmermann W, Handler J, Jensen-Jarolim E, Kammerer R. Possibilities and limitations of the CEA gene family in comparative medicine. 21st Annual International CEA Symposium, Konstanz, Germany, September 18-21, 2011 39. Weichselbaumer M, Willmann M, Reifinger M, Singer J, Bajna E, Sobanov Y, Mechteriakova D, Selzer E, Thalhammer JG, Kammerer R, Jensen-Jarolim E. Carcinoembryonic antigen: challenging biomarker in comparative medicine. 45. Austrian Society of Tropical Medicine and Parasitology, Vienna, Austria, November 17-19, 2011 40. Comparative medicine to speed up drug development. Jensen-Jarolim E, Singer J, Weichselbaumer M, Willmann M, Thalhammer J. 45. Austrian Society of Tropical Medicine and Parasitology, Vienna, Austria, November 17-19, 2011 41. Krishnamurthy D, Lukschal A, Starkl P, Diesner SC, Pali I, Untersmayr E , Jensen- Jarolim E. Anti-acid medications increase the risk of food allergy to orally applied milk allergen casein in a BALB/c mouse model. PhD Symposium, Vienna, Austria, June 15- 16, 2011
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42. Kathrin Thell K, Krisztina Szalai K, Josef Singer J, Mirko Ritter M, Beatrix Pfanzagl B, Anna Willensdorfer A, Caroline Stremnitzer C, Uwe Michaelis U, Erika Jensen-Jarolim E. Adeno-associated virus–like particles (AAVLPs) as carriers for B-cell vaccines: Immunogenicity and safety aspects. 7. PhD Symposium, Vienna, Austria, 2011 43. Stremnitzer C, Szalai K, Starkl P, Lukschal A, Willensdorfer A, Mildner M, Tschachler E, Reichart U, Brandner JM, Knapp S, Jensen-Jarolim E. The molecular requirements of house dust mite allergens Der p 1 and Der p 2 to induce allergic skin inflammation, PhD Symposium, Vienna, Austria, June 15-16, 2011 44. Diesner SC, Olivera A, Dillahunt S, Schultz C, Förster-Waldl E, Jensen-Jarolim E, Rivera J, Untersmayr E. Sphingosine-kinase 1 and 2 play a pivotal role in oral sensitization and effector phase in a mouse model of food allergy. 7th PhD Symposium (June 15-16 2010, Vienna, Austria) 45. Szöllösi H, Scheicher B, Starkl P, Felix F, Zimmer A, Jensen-Jarolim E, Pali-Schöll I: Protamine Based Nanoparticles Enhance a Th1 Mediated Immune Response. 7th PhD-Symposium, 15-16 June 2011, Vienna, Austria. 46. Jensen-Jarolim E, Nittke T, Wegmann M, Kiefer F, Klein J, Epstein MM, Esterbauer H, Fehrenbach H, Wallmann J. Metabolic cages are suitable to monitor acute hyperventilation of asthmatic mice upon allergen challenge. 30. Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11-16 May, 2011 47. Roth-Walter F, Starkl P, Gartner M, Brunner R, Singer J, Felix F, Zuberbier T, Jensen- Jarolim E, Kinaciyan T. Enhanced recognition of linearized, but not of native ovomucoid upon cooking. 30. Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11-16 May, 2011 48. Krishnamurthy D, Starkl P, Szalai K, Roth-Walter F, Untersmayr E, Diesner SC, Mannhalter C , Jensen-Jarolim E. Neutrophils and platelets participate in anaphylaxis in a BALB/c mouse model. 30. Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11-16 May, 2011 49. Zennaro D, Capalbo C, Scala E, Liso M, Spillner E, Penichet M, Singer J, Ingke B, Daniels T R., Plum M, Santoro M, Scoppola A, Marchetti P, Jensen-Jarolim E, Mari A. IgE, IgG4 and IgG response to tissue-specific and environmental antigens in patients affected by cancer. 30. Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11.-16 May, 2011 50. Singer J, Weichselbaumer M, Stockner T, Mechtcheriakova D, Sobanov Y, Wrba F, Horvat R, Thalhammer JG, Willmann M, Jensen-Jarolim E. ErbB-1 and ErbB-2 homologues are expressed in cancer of dog and recognized by cetuximab and trastuzumab antibodies. 30 Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, 11-15 June, 2011 51. Singer J, Weichselbaumer M, Stockner T, Mechtcheriakova D, Sobanov Y, Wrba F, Horvat R, Thalhammer JG, Willmann M, Jensen-Jarolim E. Evaluation of ErbB-1 and ErbB-2 homologue expression in canine cancer and their role as possible targets in comparative oncology. University lectures of vfwf 2011, General Hospital Vienna, Austria, December 2, 2011 52. Untersmayr E, Vestergaard H, Malling HJ, Bjerremann LJ, Platzer MH, Boltz-Nitulescu G, Scheiner O, Skov PS, Jensen-Jarolim E, Poulsen LK. Hindered gastric digestion represents a risk for severe reactions in food allergic patients. Verein zur Förderung von Wissenschaft und Forschung in den neuen Universitätskliniken am AKH der Stadt Wien (December 2, 2011, Vienna, Austria) 53. Lukschal A, Mari A, Harwanegg C, Wallmann J, Palazzo P, Liso M, Pali I, Jensen- Jarolim E. Prevalence of IgE, IgG4 and IgG reactivitiy to grass pollen allergen PHL P
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and its mimotope H32 in an population of Italian allergic patients. University lectures of vfwf, December 2, 2011 54. Pali-Schöll I, Szöllösi H, Starkl P, Scheicher B, Stremnitzer C, Hofmeister A, Roth- Walter A, Zimmer A, Jensen-Jarolim E. Protamine-based nanoparticles as suitable carriers in therapy of allergy. University lectures of vfwf 2011, General Hospital Vienna, Austria, December 2, 2011 55. Shakeri-Leidenmühler S, Lukschal A, Schultz C, Bohdjalian A, Greisenegger E, Langer F, Birsan T, Diesner SC, Kopp T, Scheiner O, Jensen-Jarolim E, Prager G, Untersmayr E. Surgical elimination of the gastric digestion leads to an increased risk of food protein sensitization. Verein zur Förderung von Wissenschaft und Forschung in den neuen Universitätskliniken am AKH der Stadt Wien (December 2, 2011, Vienna, Austria) 56. Svoboda M, Kaufmann T, Meshcheryakova, Bajna E, Mechtcheriakova D. Activation- induced cytidine deaminase (AID) from immunity to cancer. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 57. Meshcheryakova A, Svoboda M, Mechtcheriakova D. Multigene signature approach for systemic analysis of multifaceted roles of sphingolipids in disease etiology. Retreat of the Center of Pathophysiology, Infectiology and Immunology, Vienna, Austria, June 15-16, 2011 58. Höbaus J, Nittke T, Manhardt T, Hummel D, Kallay E. Gene amplification and epigenetic modifications: Mechanisms behind unbalanced expression of the proto- oncogene CYP24A1 in colorectal tumor. 102 Annual Meeting of the American Cancer Association, Orlando, Florida, April 2-6, 2011 59. Höbaus J, Nittke T, Khorchide M, Kallay E. Epigenetic Regulation of the Vitamin D degrading Proto-Oncogen 1,25-Hydroxyvitamin D3 24-Hydroxylase in vitro. E.16 Jahrestagung der Österreichischen Gesellschaft für Endokrinologie und Stoffwechsel, Vienna, Austria, May 12-13, 2011. 60. Höbaus J, Fetahu I, Hummel D, Manhardt T, Kallay E. Overexpression and methylation of the vitamin D degrading enzyme CYP24A1 in colorectal cancer. International Summit Conference on Calcium and Vitamin D of the Austrian Society for Bone and Mineral Research, Vienna, Austria, November, 2011, 61. Fetahu I Sh, Höbaus J, Hummel D, Manhardt T, Kallay E. Epigenetic regulation of the calcium sensing receptor. Poster presentation, Retreat of Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria, September 27, 2011 62. Fetahu I Sh, Höbaus J, Hummel D, Manhardt T, Kallay E. Epigenetic regulation of the calcium sensing receptor in colorectal cancer. Oral presentation, Annual meeting of Austrian Society and Mineral research & International Summit Conference on Calcium and Vitamin D, Vienna, Austria, November 25-26, 2011 63. Thiem U, Höbaus J, Hummel D, Nittke T, Fetahu I, Manhardt T, Borchhardt K, Kállay E. In vitro effect of 1,25-dihydroxyvitamin D3 on the catabolism of tryptophan. International Summit Conference on Calcium and Vitamin D of the Austrian Society for Bone and Mineral Research, Vienna, Austria, November, 2011 64. Hummel D, Schrewe H, Kallay E. Effects of colon-specific knockout and overexpression of 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) on vitamin D signaling in mice. June 2012, Vienna, Austria: 7th YSA-PhD-Symposium 65. Hummel D, Höbaus J, Thiem U, Fetahu I Sh, Manhardt T, Mesteri I, Kallay E. Impact of high dietary vitamin D on the effect of AOM and DSS treatment in mouse colon tissue. November 2011, Vienna, Austria: International Summit Conference on Calcium and Vitamin D of the Austrian Society for Bone and Mineral Research
18 Performance Report 2011 Comparative Immunology and Oncology g) Teaching Scripts and Books: n = 0 h) Articles in Medical Journals: n = 0 i) Public activity
Diana Mechtcheriakova MUW Open Day 2011 „Science Dabei“. Multigene-Signaturen – eine Brücke von der Forschung zur personalisierten Medizin.
Erika Jensen-Jarolim Eine Medizin für Mensch und Tier. Opening der Wiener Science Lectures.
Print: Eine Medizin für Mensch und Tier. Opening der Wiener Science Lectures. In: Unsere Hunde 12, Dezember 2011. Medical Tribune, "Schulterschluss von Veterinär- und Humanmedizin - RotePfote gegen Krebs", 04/2011 Nr. 14 Die Presse am Sonntag, "Der Hund als Patient", April 29, 2011 der Standard, "Mensch und Hund teilen sich einen Tumormarker", April 19, 2011 Der Jagdspaniel, "Eine Krebserkrankung ist kein Mysterium - Drei Jahre vergleichende Krebsforschung", Ausgabe 02-2011, Seite 50-54 Breeder Special, "Eine Krebserkrankung ist kein Mysterium - Drei Jahre vergleichende Krebsforschung", Ausgabe 01-2011, Seite 16-20 online: Professur für Erika Jensen-Jarolim. 01. August 2011. 12:51. http://derstandard.at/1311802419481/Wien-Professur-fuer-Erika-Jensen-Jarolim Forschung auf neuen Wegen. http://www.forschen-entdecken.at/Forschung-auf-neuen- Wegen.4241.0.html Tumormarker bei Mensch und Hund gleich. 18.04.2011 | 16:37 | (DiePresse.com) http://diepresse.com/home/gesundheit/651444/Tumormarker-bei-Mensch-und-Hund-gleich www.ots.at, "Verein "Rote Pfote- Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet", April 21, 2011 www.austropharm.com, "Verein "Rote Pfote- Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet", April 21, 2011 www.wuff.at, ""RotePfote - Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet. Umgang mit Spenden entspricht höchsten Qualitätsstandards", April 21, 2011 www.pr-inside.com, "Verein "Rote Pfote- Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet", April 21, 2011 www.tieraerztekammer.at, "Erste klinische Studien laufen bereits – http://www.magazinmeinhaustier.at/archiv_03_04_11.php: „Verein rote Pfote, Gemeinsame Krebsforschung für Zwei- und Vierbeiner . März/April Ausgabe 2011 http://www.4-pfoten-lebensrecht.at/3.html. Abschluss der Feldbacher Adventaktion für "RotePfote", 14. Dezember 2011 http://www.kleinezeitung.at/steiermark/fuerstenfeld/ottendorf_an_der_rittschein/2885241/ben efizaktion-fuer-tiere.story. Benefizaktion für Tiere. 24.11.2011.
19 Performance Report 2011 Comparative Immunology and Oncology http://www.austropharm.at/en/apa_show.html?ap=wik.OTS0132-20110421. Verein "Rote Pfote- Krebsforschung für das Tier" mit Spendengütesiegel ausgezeichnet http://www.ots.at/presseaussendung/OTS_20111004_OTS0223/roche-austria- publizistikpreis-2011-an-veronika-schmidt-bild
Eva Untersmayr-Elsenhuber 1. Die Wiener Zeitung „Hätte lieber einen Tumor gehabt“ 16.8.2011 http://www.wienerzeitung.at/themen_channel/wzwissen/leben/389444_Haette-lieber- einen-Tumor-gehabt.html 2. Springer Professional Media „Lebensmittel auf Krankenschein“ 25.8.2011 3. Austria Innovativ „Essen mit Nebenwirkungen“, S.24 Vol. 6/2011 j) Radio and TV interviews: n = 1
Erika Jensen-Jarolim
1. OE1, Interview Radiodoktor, Medizin und Gesundheit "Immunsystem", January 3, 2011 k) Lay Information: Brochures and Workshops: n = 1
Eva Untersmayr-Elsenhuber/Isabella Pali
1. REVAN (Richtig essen von Anfang an): Allergien vorbeugen in Schwangerschaft, Stillzeit und Säuglingsalter
1.1.2 Research Awards: n = 5
1. Pali-Schöll Isabella: Kardinal Innitzer Förderungspreis 2011. Kardinal Innitzer Studienfonds 2. Diana Mechtcheriakova: Otto-Kraupp-Preis, May 2011, Vienna, Austria 3. Josef Singer: poster prizes. 30th Congress of the European Academy of Allergy of Allergy and Clinical Immunology, June 11-15, 2011, Turkey, Istanbul (Poster Presentation, Poster Prize); 7thPhD-Symposium, Young Scientist Association of the Medical University of Vienna, June 15-16, Vienna, Austria (Poster Presentation, Poster Prize Winner) 4. Julia Höbaus: 16. Jahrestagung der Österreichischen Gesellschaft für Endokrionologie und Stoffwechsel: Auszeichnung für die Präsentation des Abstracts mit dem Titel "Epigenetic Regulation of the Vitamin D Degrading Proto-Oncogene 1,25- Hydroxyvitamin D3 24-Hydroxylase in Vitro" and CePII Retreat: Posterpreis für Poster mit dem Titel "Overexpression and Methylation of the Vitamin D Degrading Enzyme CYP24A1 in Colorectal Cancer 5. Giovanna Bises: award - Science2business Award (3rd place) at the LifeScienceSuccess 2011, TechGate, Vienna
1.1.3. Invited lectures: n = 21
Erika Jensen-Jarolim
1. Techno, Beat and Cinnamon. Pirquet Club of the Austrian Society of Allergology and Immunology, March 4, 2011.
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2. Women in Science. Office for Gender Affairs of Austrian Medical Student Association (ÖH). March 16, 2011 3. Anti-Acids and Food Allergy. International Meeting on Food Allergy. RIRAAF Seminar, IIS- FJD Fundacion Jimenez Diaz, Madrid, Spain, April 14, 2011. 4. Der Darm als Primärorgan der Sensibilisierung oder als Schaltstelle für Immuntoleranz - wie verstehen wir die Mechanismen derzeit? Pirquet Club Spezial. Vienna, May 7, 2011. 5. Gender difference and immediate type hypersensitivity reactions. European Academy of Allergy and Clinical Immunology, Geneva, Switzerland. June 17, 2011. 6. Hormone und allergisches Asthma bronchiale: Sex matters. Annual Congress of the Austrian Society of Pulmonology. Vienna, September 8, 2011. 7. Techno-Allergie: Neue Sensibilisierung mit alten Allergenen. Grazer Allergietag at Annual Meeting of the Austrian Society of Allergology and Immunology. Graz, Austria, September 17, 2011. 8. Comparative strategies to speed up Allergology and AllergoOncology. Seminar at Istituto Dermopatico Del`Immacolata (IDI), Rome, Italy. September 20, 2011. 9. Disco Fog. 32. Meeting of Working group for Indoor Air of Austrian Ministry of Agriculture, Environment and Water. September 26, 2011 10. Allergy – the immune system overreacts. 3rd Autumn School “Current Concepts in Immunology” by the German Society of Immunology. Bad Schandau, October 12, 2011. 11. Comparative Medicine – challenge and chance for translational studies. SFB- Transregio22 Symposium, Lübeck, Germany. 28. October 2011. 12. The Messerli Research Institute. 2nd Retreat of the Center of Pathophysiology, Infectiology and Immunology. September 27, 2011. 13. Comparative Medicine – Speeding up drug development. 45. Annual Meeting of the Society of Parasitology and Tropical Medicine. Society of Physicians, Vienna. November 17, 2011. 14. Allergische Reaktionen durch Duftöle in Nebelmaschinen, 4. Meeting of the Special Dept. Chemicals in Products, Ministry of BMASK Vienna. October 18, 2011, 15. Krebsimpfstoffe, warum gibt es sie noch nicht? 26. pädiatrischer Samstag, University of Linz, Austria. November 19, 2011. 16. Eine Medizin für Mensch und Tier. Vergleichende Medizin als Chance. Vienna Science Lecture. Vienna, Austria. November 23, 2011.
Eva Untersmayr
1. Food allergy and beyond: IgE and the intestine. Munich Allergy Research Center Seminar, ZAUM, TU München (15. März 2011, München, Deutschland) 2. Functional Food 2.0 – Lebensmittel auf Krankenschein? Immunologische Aspekte. BILLA Special Lecture „Functional Food 2.0 – Lebensmittel auf Krankenschein“. Gesundheitsgespräche des Europäischen Forum Alpbach (19.08.2011, Alpbach, Österreich)
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Enikö Kallay
1. 2011, May 3-5 Beirut & Byblos, Lebanon: Keynote Speaker at the Conference: Research Trends in Food Safety & Security. “New Trends in the Physiology of Vitamin D”. 2. 2011, May 3-5 Beirut & Byblos, Lebanon: Keynote Speaker at the Conference: Research Trends in Food Safety & Security. “Vitamin D and Cancer: The New State of the Art“ 3. 2011. May. 18th BMA House, London, UK, International Meeting: Vitamin D & Cancer - Treatment & Prevention. “Vitamin D and cancer: promise or reality”.
1.1.4. Congress organization
Division member National congress Intern. congress, Name: Name, date Function Name, date Function
Enikö Kallay - - Multifaceted CaSR Host, Cancer WP meeting Organisation 04/26/2011
1.1.5. Hosting speakers
division member Speaker´s name Affiliation Date Erika Jensen-Jarolim Prof. Dr. Ursula Wiedermann Inst. für Spez. Prophylaxe 04/19/2011 und Tropenmedizin, MeduniWien Erika Jensen-Jarolim Prof. Dr. Maria Sibilia Comprehensive Cancer 05/31/2011 Center MeduniWien
Erika Jensen-Jarolim Dr. Barbara Wollenberg Univ. Klinikum Lübeck 07/07/2011 Erika Jensen-Jarolim Prof. Dr. Ludwig Huber Messerli Research Institute, 14/11/2011 Vienna Diana Dr. Philip Zimmermann ETH Zürich/Nebion, Zürich 04/07/2011 Mechtcheriakova Diana DI Radu Rogojanu TissueGnostics, Vienna 04/13/2011 Mechtcheriakova
1.1.6. Mobility
Name Program University, Land Time frame Division In Out Vera Elisabeth FWF Paris Lodron Universität, 04/11/2011- 1 x Assmann Salzburg 05/06/2011
1.1.7. Activities in Advisory Boards
Name Society/Institute/Journal Function Erika Jensen-Jarolim Medical University Vienna Member of Senate
22 Performance Report 2011 Comparative Immunology and Oncology
Erika Jensen-Jarolim Research Center Borstel Member of Advisory Board Erika Jensen-Jarolim Until May 2011: University Deputy Chair of Council Council of the Veterinary University Vienna
Erika Jensen-Jarolim Wiener Wirtschaftsförderungs- Kuratorium und Technologiefonds (WWTF)
Erika Jensen-Jarolim Science jury of the county of Juror Lower Austria
1.1.8. Editorial Activities
Name Journal Function Erika Jensen-Jarolim WAO Journal Associate Editor Erika Jensen-Jarolim Wiener Med. Wochenschrift Associate Editor Erika Jensen-Jarolim Int. Archs Allergy & Immunology Associate Editor Erika Jensen-Jarolim Allergo Journal Associate Editor Erika Jensen-Jarolim Immunology Letters Associate Editor Erika Jensen-Jarolim The Open Allergy Journal Associate Editor Isabella Pali-Schöll Bentham Science Publisher reviewer for the e-book proposal “Immunology of Pregnancy”
1.1.9. Review Activities
Name Grants/Thesis/Habilitation Jensen-Jarolim Medizinisch Wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien (2x) Jensen-Jarolim Jubiläumsfonds der Österreichischen Nationalbank Jensen-Jarolim Belgian Research Fund FWG Jensen-Jarolim Wissenschaftspreise Niederösterreich Jensen-Jarolim SFB/TR22, Marburg, Germany Jensen-Jarolim LOEWE Schwerpunkt “Tumor und Entzündung” Hessen, Germany Jensen-Jarolim Professorship (Marburg, Germany) Jensen-Jarolim Professorship (Wayne State University) Jensen-Jarolim Professorship (UCLA, CA, USA) Jensen-Jarolim Master Thesis (Romina Kalod, VetmeduniVienna) Jensen-Jarolim Bachelor Thesis (H. Szöllösi, VetmeduniVienna) Kallay Bürgermeisterfond Kallay Research Foundation Flanders Kallay K.U. Leuven: Junior Research Professorship Kallay Cancer Research UK
23 Performance Report 2011 Comparative Immunology and Oncology
1.1.10. Filed and granted patents not disclosed
Name Patent
1.1.11. Grants
Funding agency Title of project Principal investigator FWF, doctoral Cellular interactions decisive for immune response Erika Jensen-Jarolim college, CCHD to oral antigens FWF Allergen mimotopes for epitope studies and Erika Jensen-Jarolim vaccination. III. Biomedical Proof of Concept-Studien für Mimotop Impfstoffe I. Erika Jensen-Jarolim International R&D GmbH Biomedical Proof of Concept-Studien für Mimotop Impfstoffe II. Erika Jensen-Jarolim International R&D GmbH FWF Targeting ERbB-1 and ERbB-2 overexpressed in Erika Jensen-Jarolim cancer of dog by passive immunotherapy with lgG versus lgE antibodies. passive immunotherapy with lgG versus lgE antibodies. FWF Development of mimotope vaccines for preclinical Erika Jensen-Jarolim and comparative medicine studies. comparative medicine studies. FWF Is cyp24a1 a proto-oncogene? A novel role for the Enikö Kallay catabolic vitamin D3 hydroxylase in colorectal tumourigenesis Herzfelder’sche Is the calcium sensing receptor a tumour Enikö Kallay Familienstiftung suppressor in colorectal cancer? EU-Marie Curie The role of the Calcium Sensing Receptor (CaSR) Enikö Kallay in health and diseases, implications for translational medicine. FWF Activation-induced cytidine deaminase (AID): from Diana Mechtcheriakova inflammation to solid cancer.
FWF Signature of sphingolipid-related genes in cancer Diana Mechtcheriakova FWF, Hertha Anti-acids induce food allergy in newborns Isabella Pali-Schöll Firnberg FFG, Nanohealth - NanoVac Isabella Pali-Schöll, Bionanoinitiative Erika Jensen-Jarolim Österreich FWF The impact of protein nitration on food allergy Eva Untersmayr-Elsenhuber induction. FWF Microparticles for oral immunotherapy of type I food Eva Untersmayr-Elsenhuber allergy
1.1.12. Career Developments a) Habilitations: n = 0 b) Habilitations in progress: n = 0
24 Performance Report 2011 Comparative Immunology and Oncology c) Professorships: n= 1
Joint Professorship for Comparative Medicine to Erika Jensen-Jarolim, at Messerli Research Institute of the Veterinary University Vienna, Medical University Vienna and University Vienna. d) Qualification Agreement: n= 0
1.1.13. Teaching a) Bachelor students: n = 1
Isabella Pali-Schöll:
Helen Szöllösi: 100% Bachelor thesis (01/02/2011 – 31/07/2011), “Protamine-based nanoparticles with CpG- Oligodesoxynucleotidies as a suitable carrier system for the induction of a Th1-mediated immune response” b) Diploma, MDiploma and Master students: n = 7
Erika Jensen-Jarolim:
Kathrin Thell: MSc Thesis. Proof of concept studies of tumor mimotope vaccines (start 2010 - ongoing). Medical University Vienna Kinkel Janis: MDiploma Thesis: Das Sensibilisierungspotenzial von durch Prozessierung veränderten Nahrungsmitteln. 2009-Ongoing. Medical University of Vienna. Felix Ferdinand: MDiploma Thesis: Der Einfluss von Prozessierung auf die Allergenität von Nahrungs- Proteinen. 2009-Ongoing. Medical University of Vienna.
Diana Mechtcheriakova:
Tamara Kaufmann: Diploma Thesis: Activation-induced cytidine deaminase (AID): potential novel biomarker and/or target during epithelial-to-mesenchymal transition program. 2011-Ongoing University of Vienna
Eva Untersmayr:
Kristina Kreiner: 100% Bachelorarbeit (01/04/2011 - 30/09/2011), "The role of sphingomyelin and its metabolites in the development of food allergies“ Vera Elisabeth Assmann: 100% Diplomand (01/04/2011 – ongoing), "Intestinal bacterial composition contributes to food allergy elicited by gastric acid suppression in a murine model“ Kristina Kreiner: 100% Diplomand (01/10/2011 – ongoing), "Prophylactic application of functionalized microparticles for prevention of food allergy“
25 Performance Report 2011 Comparative Immunology and Oncology c) PhD, MDSci, MD students: n = 19
Erika Jensen-Jarolim:
Caroline Stremnitzer: PhD thesis: Molecular characteristics and biology of house dust mite allergens Der p1 and 2 (start: 2010 - ongoing). Medical University Vienna Hadzijusufovic Emir: PhD thesis: Targeted therapy of mast cell neoplasms. (Start: 2008 - 2011). University of Veterinary Medicine Vienna. Singer Josef: PhD thesis: The role of IgE in cancer and allergy. (2010 - ongoing). Medical University of Vienna. Krishnamurthy Durga: PhD thesis: The role of the liver in the induction and control of food allergy. (Start: 10/2007 - in progress). Medical University of Vienna. Starkl Philipp: PhD thesis: Cellular and molecular mechanisms of the intestinal uptake of food allergens. (01/2007 - 09/2011). Medical University of Vienna. Lukschal Anna: PhD thesis: Epitop specific IgE detection. (2008 - in progress). Medical University of Vienna. Weichselbaumer Marlene: DVM Thesis: Immunization with carcinoembryonic antigen (CEA) mimotope vaccine inhibits growth of CEA positive mammary carcinomas in canine patients. (2008 - 2011). University of Veterinary Medicine Vienna. Bevyl Isabella: Co-Supervisor; The role of plasma surfactant protein D in lung transplant recipients during rejection and infection. Medical University of Vienna.
Eva Untersmayr:
Susanne Diesner: PhD Dissertation 50%: Perspectives on immunomodulation of the Th2 biased immune response in early life“ (10/2008 – ongoing) Philipp Starkl: PhD Dissertation: 30%: “Molecular Allergology: Sudies on Allergen-Enterocyte Interaction, Sensitization and Effector Mechanisms” (12/2006 – 09/2011)
Enikö Kallay:
Nittke Thomas: PhD Thesis: Nutritional impact on vitamin D receptor and pregnane X receptor-dependent regulation for prevention of colon tumourgenesis (09/2006 – in progress). Medical University of Vienna. Julia Höbaus: PhD Thesis: Mechanisms of 25-Hydroxyvitamin D3-24-Hydroxylase Overexpression in Colorectal Cancer (in progress) Doris Hummel: PhD Thesis: Is the vitamin D 25 hydroxylase an oncogene? (in Progress)
26 Performance Report 2011 Comparative Immunology and Oncology
Ursula Thiem: Co-Supervisor: Vitamin D and the immune system: Evaluation of the effects of high-dose vitamin D3 therapy in the immune response in vitamin D deficient kidney transplant recipients. Irfete Fetahu: PhD Thesis: “Regulators of the Calcium Sensing Receptor in colorectal cancer” Samawansha Tennakoon: PhD Thesis: "Ligand-dependent CaSR signalling in colonocytes" Abishek Aggarwal: PhD Thesis: "Role of CaSR in proliferation of Colon Cancer Cells"
Diana Mechtcheriakova:
Anastasia Meshcheryakova: PhD Thesis: “Definition of novel breakpoints in the sphingolipid machinery associated with malignancy” (08/2011 - in progress) Medical University of Vienna.
1.1.14. Exams a) Oral examinations: n = 2 b) Bachelor, Diploma and Thesis-Examinations: n= 10
Evelyn Dixit, Diploma Thesis (MedUniWien) Evren Karayel, Diploma Thesis (MedUniWien) Jörg Puffing, Diploma Thesis, 27.04.2010. Helen Szöllösi, Bachelor Thesis, 28.09.2011 Ursula Thiem, Diploma Thesis, 08.07.2010; Matrikelnummer: 0351588. Almira Kovacevic, MD Diplom-Prüfungen (MedUniWien) Sabrina Weiss, MD Diplom-Prüfungen (MedUniWien) Nergius Rehan Ghanin, MD Diplom-Prüfungen (MedUniWien) DVM Diss: S. Liederer (VetmedUni) Leticia Tordesillas Villuendas, PhD (Univ. Madrid) c) Exam supervising: n=14
27 Performance Report 2011 – Division 1 Comparative Immunology and Oncology
1.1.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2011 Jensen-Jarolim Erika 4.00 1.00 808.004 SSM 3 Projektstudie (Wahlpflichtteil) Jensen-Jarolim Erika 4.00 0.28 860.117 Basic Seminar CCHD Jensen-Jarolim Erika 6.00 0.11 860.202 CCHD Doctoral Seminar Jensen-Jarolim Erika 2.00 0.67 902.707 Journal Club und Progress Report – New developments Jensen-Jarolim Erika 2.00 0.07 902.708 Basisvorlesung Immunologie Jensen-Jarolim Erika 2.00 0.03 902.733 CCHD Journal Club Kallay Enikö 2.00 0.23 860.400 Basic Seminar Malignant Diseases II Kallay Enikö 1.00 0.33 860.034 Journal Club (N090, N094 and N0790) Mechtcheriakova Diana 2.00 0.66 902.707 Journal Club and Progress Report – New developments Mechtcheriakova Diana 6.00 0.06 860.202 CCHD Doctoral Seminar Mechtcheriakova Diana 2.00 0.04 902.733 CCHD Journal Club Dissertantenseminar: New Developments and highlights in allergolocy, Pali-Schöll Isabella 2.00 0.40 648.010 oncology and immunology Pali-Schöll Isabella 2.00 0.40 648.029 Progress Report in Experimental Immunology and Oncology Immunpathologisches Seminar – Immunpathologisches Seminar Pali-Schöll Isabella 3.00 1.00 648.950 (Wahlausbildung gem. § 13/1 lit.a StG.) Pali-Schöll Isabella 2.00 0.10 860.971 CCHD Journal Club – SS 2011 Pali-Schöll Isabella 2.67 0.15 891.016 Module I – Immunologie, Allergologie, Onkologie Dissertantenseminar: New Developments and highlights in allergolocy, Untersmayr-Elsenhuber Eva 2.00 0.40 648.010 oncology and immunology Untersmayr-Elsenhuber Eva 2.00 0.40 648.029 Progress Report in Experimental Immunology and Oncology Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 Untersmayr-Elsenhuber Eva 5.00 2.00 648.031 lit. a StG) Immunpathologisches Seminar - Immunpathologisches Seminar Untersmayr-Elsenhuber Eva 3.00 1.00 648.950 (Wahlausbildung gem. § 13/1 lit.a StG.) Untersmayr-Elsenhuber Eva 2.00 0.10 860.971 CCHD Journal Club - SS 2011 Untersmayr-Elsenhuber Eva 3.00 0.21 896.005 Gender - Basics in Gender Medizin Journal Club und Progress Report - New developments and highlights in Untersmayr-Elsenhuber Eva 2.00 0.50 902.707 allergology, oncology and immunology Sum 10.14
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Performance Report 2011 Comparative Immunology and Oncology
WS 2011/12 Jensen-Jarolim Erika 2.00 0.18 502.282 Propedeutics in Human Medicine III – Linking Biology and Medicine Jensen-Jarolim Erika 1.00 0.25 514.094 Pathophysiologie der Allergie Jensen-Jarolim Erika 2.00 0.20 562.019 BVo: Immunologie Jensen-Jarolim Erika 3.00 0.75 648.011 Immunpathologische Laboratoriumstechnik mit Demonstrationen Jensen-Jarolim Erika 5.00 2.50 648.012 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten) Jensen-Jarolim Erika 5.8 0.40 803.002 BL8-Krankheit, Krankheitsursachen und Krankheitsbilder Jensen-Jarolim Erika 2.00 0.67 860.057 Journal Club und Progress Report Dissertantenseminar: New Developments and highlights in allergology, Jensen-Jarolim Erika 2.00 0.50 860.079 oncology and immunology Jensen-Jarolim Erika 4.00 0.28 860.117 Basic Seminar CCHD Jensen-Jarolim Erika 6.00 0.11 860.600 DTS CCHD Doctoral Seminar – WS 2010 Jensen-Jarolim Erika 2.00 0.14 860.946 JC CCHD WS 2010 Jensen-Jarolim Erika 2.00 0.02 902.563 Progress Report in Experimental Immunology and Oncology Wachstumsregulation humaner Kolontumorzellen - (Wahlfachausbildung gem. Kallay Enikö 5.00 5.00 514.051 § 13 StG) Kallay Enikö 5.80 0.27 803.002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Kallay Enikö 2.20 1.07 803.003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Kallay Enikö 2.00 2.00 803.009 Problemorientiertes Lernen - 3. Semester Kallay Enikö 1.00 0.33 860.011 Creative and critical Journal Club I TS: New Developments and comparative aspects in allergology, oncology and Kallay Enikö 2.00 0.40 860.061 immunology Kallay Enikö 2.00 0.20 860.966 Basisseminar Zelluläre Signaltransduktion Pali-Schöll Isabella 1.00 0.20 514.094 Pathophysiologie der Allergie Pali-Schöll Isabella 3.00 0.09 805.000 BL13-Ernährung und Verdauung TS: New Developments and comparative aspects in allergology, oncology and Pali-Schöll Isabella 2.00 0.40 860.061 immunology JC New Developments and comparative aspects in allergology, oncology and Pali-Schöll Isabella 2.00 0.29 860.060 immunology Pali-Schöll Isabella 6.00 0.24 860.600 DTS CCHD Doctoral Seminar Mechtcheriakova Diana 3.00 0.75 648.011 Immunopathologische Laboratoriumstechnik mit Demonstrationen Mechtcheriakova Diana 2.00 0.66 860.057 Journal Club and Progress Report Dissertantenseminar: New Developments and highlights in allergology, Mechtcheriakova Diana 2.00 0.50 860.079 oncology and immunology
29 Performance Report 2011 Comparative Immunology and Oncology
Mechtcheriakova Diana 6.00 0.06 860.600 DTS CCHD Doctoral Seminar Mechtcheriakova Diana 2.00 0.04 860.946 JC CCHD WS2010 Mechtcheriakova Diana 2.00 0.66 902.563 Progress Report in Experimental Immunology and Oncology Untersmayr-Elsenhuber Eva 1.00 0.50 514.094 Pathophysiologie der Allergie Immunpathologische Laboratoriumstechnik - mit Demonstrationen (Wahlfach Untersmayr-Elsenhuber Eva 3.00 1.00 648.011 gem. § 13/1 lit. a StG) Untersmayr-Elsenhuber Eva 5.00 2.50 648.012 Wissenschaftliche Arbeiten (Wahlfach für Dissertanten gem. § 13/1 lit. a StG) JC New Developments and comparative aspects in allergology, oncology and Untersmayr-Elsenhuber Eva 2.00 0.29 860.060 immunology TS: New Developments and comparative aspects in allergology, oncology and Untersmayr-Elsenhuber Eva 2.00 0.40 860.061 immunology Untersmayr-Elsenhuber Eva 1.00 800.000 Senior-Mentoring Humanmedizin Untersmayr-Elsenhuber Eva 6.00 0.29 860.599 TS: CCHD Doctoral Seminar - WS 2011
Sum 24.14
Total sum SS+WS 34.28
30 Performance Report 2011 Cellular and Molecular Pathophysiology
1.2. Division for Cellular and Molecular Pathophysiology Head: Peter Pietschmann, MD, Associate Professor
1. Publications5 IF Number Top/Std/Subst Isabella Ellinger 2.423 1 1x St Renate Fuchs 3.305 1 1x St Peter Pietschmann 20.421 7.2 1x Top, 5x St, 1x SSt Theresia Thalhammer 28.148 10.2 1xTop 8x St, 1xSSt Sum Division 54.297 19.4 Top point score 2 – among top 20 % of journal in field Standard point score 1 – between 21-60 %, Substandard point score 0,2
2. Supervision of bachelor, diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Isabella Ellinger 1 0 2 Renate Fuchs 1 2 0 Peter Pietschmann 0 7 3 Theresia Thalhammer 3 13 3 Sum 5 22 8
3. Teaching SS* WS* total W+S oral Exams Isabella Ellinger 1.67 10.08 11.75 0 Renate Fuchs 1.84 11.93 13.77 0 Peter Pietschmann 4.91 6.41 11.32 3 Theresia Thalhammer 6.99 5.66 12.65 0 Sum 15.41 34.08 49.49 3
5 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 31
Performance Report 2011 Cellular and Molecular Pathophysiology
1.2.1. Publications a) Peer-reviewed original articles: n = 16
Nr. Article IF Class 1. Patsch, J.M., F.W. Kiefer, P. Varga, P. Pail, M. Rauner, D. 2.538 St Stupphann, H. Resch, D. Moser, P.K. Zysset, TM Stulnig, and P. Pietschmann. Increased bone resorption and impaired bone microarchitecture in short-termin and extended high-fat- diet induced obesity. Metabolism, 2011, 60 (2):243-249 2. Patsch, J.M., T. Kohler, A. Berzlanovich, C. Muschitz, C. 7.084 Top Bieglmayr, P. Roschger, H. Resch, and P. Pietschmann. Trabecular bone microstructure and local gene expression in iliac crest biopsies of men with idiopathic osteoporosis. J Bone Miner Res, 2011, 26 (7):1584-1592. doi: 10.1002/jbmr.344. 3. Sipos, W. E. Kralicek, M. Rauner, C. Duvigneau, H. 2.414 St Worliczek, D. Schamall, R. Hartl, I. Sommerfeld-Stur, E. Dall’Ara, P. Varga, H. Resch, P. Zyssett, and P. Pietschmann. Bone and cellular immune system of multiparous sows are insensitive to ovariectomy and nutritive calcium shortage. Horm Metab Res, 2011, 43:404-409 4. Sipos, W., P. Zysset, P. C. Kostenuik, E. Mayrhofer, C. 2.414 St Bogdan, M. Rauner, M. Stolina, D. Dwyer, I. Sommerfeld-Stur, G. Pendl, H. Resch, E. Dall’Ara, P. Varga, and P. Pietschmann. OPG-Fc treatment in growing pigs leads to rapid reduction in bone resorption markers, serum calcium, and bone formation markers. Horm Metab Res, 2011, 43:944- 949 5. Kubista, B., F. Klinglmüller, M. Bilban, M. Pfeiffer, R. Lass, A. 1.561 St Giurea, P.T. Funovics, C. Toma, M. Dominkus, R. Kotz, T. Thalhammer, K. Trieb, T. Zettl, and C.F. Singer. Microarray analysis identifies dinstinct gene expression profiles associated with histological subtype in human osteosarcoma. Int Orthop, 2011, 35(3):401-411. doi: 10.1007/s00264-010- 0996-6 6. Wlcek, K., M. Svoboda, J. Riha, S. Zakaria, U. Olszewski, Z. 2.907 St Dvorak, F. Sellner, I. Ellinger, W. Jäger, and T. Thalhammer. The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer. Cancer Biol Ther, 2011, 11(9):801-811. http://dx.doi.org/10.4161/cbt.11.9.15176 7. Rögelsperger, O., K. Wlcek, C. Ekmekcioglu, S. Humpeler, 1.822 St M. Svoboda, R. Königsberg, M. Klimpfinger, W. Jäger, and T. Thalhammer. Melatonin receptors, melatonin metabolizing enzymes and cyclin D1 in human breast cancer. J Recept Signal Transduct Res, 2011, 31(2):180-187. PMID:21385053 8. Böhmdorfer, M., A. Maier-Salamon, B. Taferner, G. Reznicek, 3.031 St T. Thalhammer, S. Hering, A. Hüfner, W. Schühly, and W. Jäger. In vitro metabolism and disposition of honokiol in rat and human livers. J Pharm Sci, 2011, 100(8):3506-3516. doi:10.1002/jps.22536 9. Maier-Salamon, A., M. Böhmdorfer, T. Thalhammer, T. 2.558 St Szekeres, and W.Jäger. Hepatic glucuronidation of resveratrol: interspecies comparison of enzyme kinetic profiles in human,
32 Performance Report 2011 Cellular and Molecular Pathophysiology
mouse, rat, and dog. Drug Metab Pharmacokinet, 2011, 26(4):364-373.PMID:21512262 10. Kounnis, V., E. Ioachim, M. Svoboda, A. Tzakos, I. Sainis, T. 0.176 SSt. Thalhammer, G. Steiner, and E. Briasoulis. Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals an new class of potential therapeutic targets. Onco Targets Ther, 2011, 4:27-32. 11. Svoboda, M., K. Wlcek, B. Taferner, S. Hering, B. Stieger, D. 2.208 St. Tong, R. Zeillinger, T. Thalhammer, and W. Jäger. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport. Biomed Pharmacother, 2011, 65(6):417-426. PMID:21719246 12. Schmid, D., M. Svoboda, A. Sorgner, I. Moravcevic, T. 2.451 St. Thalhammer, P. Chiba, and T. Möslinger. Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions. Life Sci, 2011, 7:89(19-20):725-734. PMID:21925514 13. Nemeth, C., S. Humpeler, E. Kallay, I. Mesteri, M. Svoboda, 2.825 St. O. Rögelsperger, N. Klammer, T. Thalhammer, and C. Ekmekcioglu. Decreased expression of the melatonin receptor 1 in human colorectal adenocarcinomas. J Biol Regul Homeost Agents, 2011, 25(4):531-542. PMID:22217986 14. Schulten, V., I. Lauer, S. Scheurer, T. Thalhammer, and B. 4.713 Top Bohle. A food matrix reduces digestion and absorption of food allergens in vivo. Mol Nutr Food Res, 2011, 55(10):1484-1491. doi:10.1002/mnfr.201100234 15. Khan, A.G., A. Pickl-Herk, L. Gajdzik, T.C. Marlovits, R. 3.305 St. Fuchs, and D. Blaas. Entry of a heparan sulphate-binding HRV8 variant strictly depends on dynamin but not on clathring, caveolin, and flotillin. Virology, 2011, 412(1):55-67. PMID:21262518 16. Schepelmann, M., L. Molcan, H. Uhrova, M. Zeman, and I. 2.423 St. Ellinger. The presence and localization of melatonin receptors in the rat aorta. Cell Mol Neurobiol, 2011, 31(8):1257-65. doi.10.1007/s10571-011-9727-9 sum 44.43 b) Invited Articles & Reviews with IF: n = 4
Nr. Article IF Class 1. Diesner S.C., E. Untersmayr, P. Pietschmann, E. Jensen- 2.203 St. Jarolim. Food allergy: Only a pediatric disease? Gerontology, 2011, 57(1):28-32 2. Azizi-Semrad U., J. Grillari, B. Grubek-Loebenstein, P. 3.411 St. Pietschmann. Biogerontology in Austria. Biogerontology, 2011, 12(1):3-10 3. Kerschan-Schindl K., P. Pietschmann. Rehabilitation bei 0.357 SSt. Osteoporose. Phys Med Rehab Kuror, 2011, 21:139-150 4. Svoboda, M., J Riha, K. Wcek, W. Jäger, and T. 3.896 St. Thalhammer. Organic anion transporting polypeptides (OATPs): regulation of expression and function. Curr Drug Metab, 2011, 12(2):139-153. PMID:21395542 sum 9.867
33 Performance Report 2011 Cellular and Molecular Pathophysiology c) Invited Articles & Reviews without IF: n = 3
1. Patsch J.M., J. Deutschmann, P. Pietschmann. Gender aspects of osteoporosis and bone strength. Wien Med Wochenschr, 2011,161/5-6:117-123 2. Bröll H., H. Resch, P. Bernecker, M. Blauth, H. Concin, P. Dimai, H. Dobnig, L. Erlacher, A. Fahrleitner-Pammer, R. Gasser, M. Herold, G. Holzer, J. Huber, B. Jilma, M. Kraenzlin, B. Leeb, S. Leodolter, H. Minne J. Patsch, P. Pietschmann, E. Preisinger, R. Windhager. Experten Statement (2011) Denosumab – aktueller Stellenwert in der Osteoporosebehandlung. Österreichische Ärztezeitung, 2011, (6):2-7 3. Bröll J., H. Resch, P. Bernecker, H. Concin, P. Dimai, H. Dobnig, L. Erlacher, A. Fahrleitner-Pammer, R. Gasser, M. Herold, L.C. Hofbauer, G. Holzer, J. Huber, M. Köller, M. Kränzlin, S. Leodolter, R. Maier, P.F. Peichl, M. Peterlik, P. Pietschmann, E. Preisinger, A. Rieder, A. Wicker, R. Windhager. Konsensus Osteoporose – Prävention & Therapie. Österreichische Ärztezeitung, 2011, (12):3-16 d) Book contributions: n = 9
1. Patsch J, P. Pietschmann. Degenerative und altersassoziierte Erkrankungen. In: Marian B (ed). Krankheit, Krankheitsursachen und –bilder (MCW Block 8). Facultas Verlag 2011, pp. 422-426 2. Erlacher I, Azizi-Semrad U, Pietschmann P. Bausteine des Bindegewebes. In: Dunky A, Graninger W, Herold M, Smolen J, Wanivenhaus A (eds).Praktische Rheumatologie. SpringerWienNewYork 2011, pp. 9-13 3. Heindl A, Schepelmann M, Ecker R, Pietschmann P, Ellinger I, Seewald AK, Thalhammer T. Towards the automated detection and characterization of osteoclasts in microscopic images. In: Pietschmann P (ed). Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2011, pp. 27-48 4. Azizi-Semrad U, Pietschmann P, Willheim M. Effects of vitamin D in the immue system. In: Pietschmann P (ed). Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2011, pp. 63-90 5. Bertl K, Pietschmann P, Matejka M. Osteoimmunological aspects of peridontal diseases. In: Pietschmann P (ed). Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2011, pp. 241-267 6. Patsch J: RANKL und Osteoprotegerin in der Pathogenese der Osteoporose. In: Pietschmann P (ed): Osteoimmunologie – Zytokine und Biologika in der Osteologie. UNI-MED Verlag Bremen – London – Boston, 2011, 2nd edition, pp 66-72 7. Pietschmann P, Nanoff C, Dudczak R, Kainberger F: Knochen- und Kalzium- Stoffwechsel. In: Ludvik B, Bischof M, Kraupp M, Luger A (eds): Endokrinologie und Stoffwechsel, Facultas Verlag 2011, 5nd edition, pp 195-208 8. Pietschmann P: Autoimmunendokrinologie. In: Ludvik B, Bischof M, Kraupp M, Luger A (eds): Endokrinologie und Stoffwechsel, Facultas Verlag 2011, 5nd edition, pp 209-216 9. Pietschmann P, Kerschan-Schindl K, Redlich K, Aringer M: Osteoporose und weitere metabolische Osteopathien. In: Stummvoll G, Pretterklieber ML, Kainberger F(eds): Bewegung und Leistung (MCW Block 21), Facultas Verlag 2011, 8nd edition, pp 172- 184
34
Performance Report 2011 Cellular and Molecular Pathophysiology e) Abstracts, printed in periodicals: n = 9
1. Schepelmann M, Heindl A, Seewald A , Nussbaumer A, Bises G, Rogojanu R, Pietschmann P, Ellinger I , Thalhammer T (2011). Influence of melatonin on murine osteoclast formation in culture – Automated detection and quantification by a novel image analysis system. Bone 48: P112-S, p. 133 2. Heindl A, Schepelmann M, Stumberger R, Nussbaumer A, Pietschmann P, Bises G, Rogojanu R, Thalhammer T, Seewald A, Ellinger I (2011). Automated detection, quantification and characterization of osteoclasts in cultures using a combined image- processing and machine-learning strategy. Bone 48:PP082-S, p. 125 3. Schepelmann M, Heindl A, Uhrova H, Pohl V, Rogojanu R, Seewald A, Helmer H, Ellinger I (2011). The neonatal IgG Fc-receptor (FcRn) is expressed in the syncytiotrtophoblast, fetal endothelial cells and Hofbauer cells of human term placental chorionic villi. Placenta 32(9):A54 4. Sipos W, Kralicek E, Rauner M, Duvigneau CJ, Worliczek HL, Schamall D, Hartl RT, Sommerfeld-Stur I, Dall’Ara E, Varga P, Resch H, Zysset P, Pietschmann P (2011). The skeleton of multiparous sows is protected from effects of ovariectomy and calcium deprivation. Bone 48:P313-S, p. 198 5. Föger-Samwald U, Patsch JM, Deutschmann J, Hornek L, Salem S, Becker P, Pail P, Schamall D, Mousavi M, Becker S, Kainberger FM, Pietschmann P (2011). Gene expression and bone architecture in men with osteoporotic hip fractures. Journal für Mineralstoffwechsel 18 (3), p. 7 6. Heindl A, Schepelmann M, Seewald A, Burger K, Bises , Rogojanu R, Ecker R, Pietschmann P, Thalhammer T, Ellinger I (2011) A machine learning-based approach to automatically discriminate In Silicio murine osteoclasts and their precursor cells by nuclei-based features. Journal für Mineralstoffwechsel 18 (3), p. 8 7. Kurz M, Rauner M, Brünner-Kubath C, Kapfenberger A, Föger-Samwald U, Schamall D, Varga P, Kudlacek S, Wutzl A, Höger H, Sipos W, Zysset PK, Shi GP, Pietschmann P (2011) Cathepsin S-deficient mice exhibit a bone and fat phenotype. Journal für Mineralstoffwechsel 18 (3), p. 10 8. Kerschan-Schindl I, Riss P, Krestan C, Rauner M, Bieglmayer C, Gleiss A, Fialka- Moser V, Niederle B, Pietschmann P (2011) Bone metabolism in patients with primary hyperparathyroidism before after surgery. Journal für Mineralstoffwechsel 18 (3), p. 10 9. Schamall D, Pietschmann P, Moser D, Dockner M, Teschler-Nicola M (2011) Monteggia fracture and multiple traumata in mediaeval skeletal remains analysed by µCT and histology. Journal für Mineralstoffwechsel 18 (3), p. 14 f) Abstracts, in congress proceedings or abstract books: n = 29
1. Brabec-Zaruba M, Niapir M, Ellinger I, Ellinger A, Blaas D, Fuchs R. Characterization of human replication vesicles. 11th Hunter Meeting, Pokolbion, Australia, March 22-25, 2011, Abstract Book 2. Brabec-Zaruba M, Niapir M, Ellinger I, Ellinger A, Blaas D, Fuchs R. Characterization of human replication vesicles. (Poster) Gordon Research Conference „Viruses and Cells, Ciocco, Italy, May 29 – June 3, 2011 3. Schepelmann M, Heindl A, Seewald , Nussbaumer A, Bises G, Rogojanu R, Pietschmann P, Ellinger I , Thalhammer T. Influence of melatonin on murine osteoclast formation in culture – Automated detection and quantification by a novel image analysis system. 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, Athen, Greece, May 7-11
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4. Heindl A, Schepelmann M, Stumberger R, Nussbaumer A, Pietschmann P, Bises G, Rogojanu R, Thalhammer T, Seewald A, Ellinger I. Automated detection, quantification and characterization of osteoclasts in cultures using a combined image- processing and machine-learning strategy. 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, Athen, Greece, May 7-11 5. Sipos W, Kralicek E, Rauner M, Duvigneau CJ, Worliczek HL, Schamall D, Hartl RT, Sommerfeld-Stur I, Dall’Ara E, Varga P, Resch H, Zysset P, Pietschmann P. The skeleton of multiparous sows is protected from effects of ovariectomy and calcium deprivation. (Poster) 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, Athen, Greece, May 7-11, 2011 6. Svoboda M, Wlcek K, Riha J, Tong DC, Zeillinger R, Jäger W, Thalhammer T. OATP Transportproteine in hepatischen und extrahepatischen Tumoren. Bad Herrenalber Transporter- und Barriere-Tage 2011, Bad Herrenalb, Germany, June 1, 2011. Abstract Book. 7. Jäger W, Wlcek K, Svoboda M, Taferner B, Hering S, Thalhammer T. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport (V07). CESAR Annual Meeting, Greifsfeld, Germany, June 16-18, 2011, abstract book 8. Heindl A, Schepelmann M, Pietschmann P, Bises G, Rogojanu R, Seewald A, Ellinger I, Thalhammer T. Automated detection of osteoclasts in-vitro in large-scale experiments using a combined image-processing and machine-learning approach. 7. PhD Symposium, Vienna, June 15-16, 2011. Abstracts S9, p. 44 9. Rogojanu R, Mesteri I, Ellinger I, Thalhammer T, Heindl A, Seewald A, Bises G, The relation between epithelial and stromal area is important for colorectal cancer diagnosis and therapeutic considerations. 7. PhD Symposium, Vienna, June 15-16, 2011. Abstracts P181, p. 144 10. Jäger W, Wlcek K, Svoboda M, Taferner B, Hering S, Thalhammer T. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport (V07).(Poster). 7th International Research Conference “Membrane Transporters in Drug Discovery”, Grindelwald, Switherland, August, 7-11, 2011 11. Schepelmann M, Heindl A, Uhrova H, Pohl V, Rogojanu R, Seewald A, Helmer H, Ellinger I. The neonatal IgG Fc-receptor (FcRn) is expressed in the sycytiotrophoblast fetal endothelial cells and Hofbauer cells of human term placental chorionic villi. (Poster) 14th IFPA Meeting in Norway, September 14-17, 2011 12. Jungmann D, Gajdzik L, Blaas D, Fuchs R. The sodium-proton exchange inhibitor EIPA affects multiple steps in the replication cycle of human rhinovirus (HRV2) (Poster) EMBO Conference “Dynamic Endosomes – Mechanisms Controlling Endocytosis”, Kreta, Greece, September 25 – 28, 2011 13. Föger-Samwald U, Patsch JM, Deutschmann J, Hornek L, Salem S, Becker P, Pail P, Schamall D, Mousavi M, Becker S, Kainberger FM, Pietschmann P. Gene expression and bone architecture in men with osteoporotic hip fractures. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011 14. Kurz M, Rauner M, Brünner-Kubath C, Kapfenberger A, Föger-Samwald U, Schamall D, Varga P, Kudlacek S, Wutzl A, Höger H, Sipos W, Zysset PK, Shi GP, Pietschmann P. Cathepsin S-deficient mice exhibit a bone and fat phenotype. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011
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15. Schepelmann M, Heindl A, Uhrova H, Pohl V, Rogojanu R, Seewald A, Helmer H, Ellinger I. The neonatal IgG Fc-receptor (FcRn) is expressed in the sycytiotrophoblast fetal endothelial cells and Hofbauer cells of human term placental chorionic villi. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011 16. Heindl A, Thalhammer T, Bises G, Schepelmann M, Rogojanu R, Ecker R, Seewald A, Ellinger I. A versatile automated detection system for erythrocytes in human tissue sections. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011 17. Heindl A, Schepelmann M, Seewald A, Nussbaumer A, Bises G, Rogojanu R, Ecker R, Pietschmann P, Thalhammer T, Ellinger I. Automated nucle-based in silico discrimination of murine osteoclasts and their precursor cells. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011 18. Rogojanu R, Thiem U, Meseteri I, Ellinger I, Thalhammer T, Heindl A, Seewald A, Bises G. Epithelium/Stroma ratio in colorectal cancer: automated area detection and quantitative analysis. (Poster ) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011 19. Schepelmann M, Heindl A, Seewald A, Nussbaumer A, Bises G, Rogojanu R, Ecker P, Pietschmann P, Ellilnger I, Thalhammer T. Automated detection and quantification of osteoclasts in culture by a novel image analysis system – a pilot study on the influence of the hormone melatonin on osteoclast formation. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011 20. Thiem U., Rogojanu R, Meseteri I, Ellinger I, Thalhammer T, Heindl A, Seewald A, Bises G. Is intra-tumoral budding correlated with liver metastasis in patients with grade 2 colorectal cancer? – A pilot study. (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011 21. Gajdzik L, Jungmann D, Blaas D, Fuchs R. The sodium-proton exchange inhibitor eipa affects multiple steps in the replication cycle of human rhinovirus 2 (HRV2). (Poster) 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 27, 2011 22. Svoboda M, Riha J, Jäger W, Castilo-Tong DC, Zeillilnger R, Van Gorp T, Vergot I, Braicu I, Sehouli J, Mahner S, Fogel M, Thalhammer T. OATP family members in ovarian cancer and their potential role in tumor therapy. 15th International Symposium on Molecular Medicine, Rhodos, Greece, October 6-8, 2011, printed abstract 23. Bises G, Mesteri I, Thiem U, Ellinger I, Thalhammer T, Heindl A, Seewald A, Rogojanu R. Automated quantitative analysis of epithelial and stromal area in colorectal cancer: putative application for the prognosis of cancer progression. 7th NCRI Cancer Conference , Liverpool, UK, November 6-9, 2011 24. Heindl A, Schepelmann M, Seewald A, Burger K, Bises , Rogojanu R, Ecker R, Pietschmann P, Thalhammer T, Ellinger I. A machine learning-based approach to automatically discriminate In Silicio murine osteoclasts and their precursor cells by nuclei-based features. (Poster) Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 -26, 2011. 25. Kurz M, Rauner M, Brünner-Kubath C, Kapfenberger A, Föger-Samwald U, Schamall D, Varga P, Kudlacek S, Wutzl A, Höger H, Sipos W, Zysset PK, Shi GP, Pietschmann P. Cathepsin S-deficient mice exhibit a bone and fat phenotype. (Poster) Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 – 26, 2011.
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26. Föger-Samwald U, Patsch JM, Deutschmann J, Hornek L, Salem S, Becker P, Pail P, Schamall D, Mousavi M, Becker S, Kainberger FM, Pietschmann P. Gene expression and bone architecture in men with osteoporotic hip fractures. (Poster) Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 – 26, 2011. 27. Kerschan-Schindl I, Riss P, Krestan C, Rauner M, Bieglmayer C, Gleiss A, Fialka- Moser V, Niederle B, Pietschmann P (2011) Bone metabolism in patients with primary hyperparathyroidism before after surgery. Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 – 26, 2011. 28. Schamall D, Pietschmann P, Moser D, Dockner M, Teschler-Nicola M. Monteggia fracture and multiple traumata in mediaeval skeletal remains analysed by µCT and histology. (Poster) Wissenschaftliche Herbsttagung 2011 der Österr. Gesellschaft für Knochen und Mineralstoffwechsel, November 25 – 26, 2011. 29. Jungmann D, Gajdzik L, Blaas D, Fuchs R. The sodium-proton exchange inhibitor EIPA affects multiple steps in the replication cycle of human rhinovirus (HRV2) (Poster) Fakultätsvorlesung, MUW, December 2, 2011 g) Teaching Scripts and Books: n = 2
1. Pietschmann P. Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2011 2. Pietschmann P. Osteoimmunologie – Zytokine und Biologika in der Osteologie. Uni- Med Verlag Bremen-London-Boston 2011, 2nd edition h) Articles in Medical Journals: n = 0 i) Public activity n = 4
1. Interview Peter Pietschmann „Die Entzündung ist ein Hilfeschrei des Körpers“ Elf Ärzte diskutieren- Wann braucht der Patient externes Kortison?, Ärzte Woche – Die österreichische Zeitung für Medizin, Politik und Praxis, Nr. 20, 19. Mai 2011, 25. Jahrgang 2. Interview Peter Pietschmann „Zur Beschleunigung der osteologischen Grundlagenforschung – Die ätiologischen Nebel lichten sich“, Spectrum Osteoporose, Seite 6-7, 1/2011 3. “Science Labs – erleben Sie Forschungslabors live – Osteoporose – Warum Knochen brechen – Zellen Zählen”, by Mag. Ursula Föger Samwald, etc. Science dabei – Das große Forschungsfest der MedUni Wien, 7.10.2011 4. Interview Peter Pietschmann “Es muss nicht immer Osteoporose sein”, Universum Innere Medizin, 09/11, Seite 89.
1.2.2. Research Awards: n = 4
1. Dr. Janina Patsch, Wissenschaftspreis 2011 der Österreichischen Gesellschaft für Wirbelsäulenchirurgie für die Arbeit “Increased bone resorptio and impaired bone microarchitecture in short-term and extended hig-fat diet-induced obesity. 2. Dr. Isabella Ellinger, Nomination by the Medical University of Vienna for the Dr. Wolfgang Houska Price 2010, 24/01/2011 3. Dr. Isabella Ellinger, Science2business-Award at the Life-Science-Success 2011, Vienna, 15/03/2011 38 Performance Report 2011 Cellular and Molecular Pathophysiology
4. DI Radu Rogojanu, Best poster presentation in poster workshop 17 at 7th PhD Symposium 2011, Vienna, 16/06/2011
1.2.3. Invited lectures: n = 38
Isabella Ellinger:
1. A new vista on disease pattern. Novel strategies in automated recognition of complex tissue and cell structures using the TissueFAXSTM platform. TissueGnostics Tag- AKH, Wien, 30.03.2011 2. Cell-City“ – Was geht ab in der Zelle? Einführung in die Welt der Zellorganellen. Kinderuni, Vienna, 19.07.2011 3. Workshop „Cell-City“ für Volksschüler, Volksschule Julius Meinlgasse 1, 1160 Wien, 18.02.2011 4. Workshop „Cell-City“ für Volksschüler, Volksschule, Hauptstrasse 22, A-3423 Kritzendorf, 02.05.2011 5. Eine neue Sicht auf Krankheitsbilder. Sciencedabei Tag an der Medizinischen Universität Wien, 7.10.2011 6. Workshop „Forschen mit allen Sinnen“,Volksschule Julius Meinlgasse 1, 1160 Wien, 07.12.2011
Andreas Heindl: 1. Automated detection of osteoclasts in-vitro in large-scale experiments using a combined image-processing and machine-learning approach 7. PhD-Symposium Medical University of Vienna, June 15, 2011 2. A machine learning-based approach to automatically disriminate in silico murine osteoclasts and their precursor cells by nuclei-based features . Wissenschaftliche Herbsttagung der ÖGKM, November 2011
Janina Patsch:
1. Ergebnisse der TOMIBA-Studie. Wissenschaftliche Herbsttagung 2011, Wien, 26. November 2011
Peter Pietschmann:
1. Geriatrie und Gerontologie in Österreich. Perspektiven – Pflegewissenschaft und Geriatrie (ÖGGG), Haus der Barmherzigkeit, Wien, 28.1.2011 2. Denosumab in der Therapie der postmenopausalen Osteoporose. Osteo ÖGKM Kolleg, Wien, 8.3.2011 3. Physiologie und Pathophysiologie des Knochenstoffwechsels. Osteoporoseseminar 2011, Hafnersee/Keutschach, Kärnten, 18.3.2011 4. Neues in der Osteoporosetherapie. Osteoporoseseminar 2011, Hafnersee /Keutschach, Kärnten, 19.3.2011 5. Low Bone Turn over Frakturen. Osteologie 2011, Fürth, Deutschland, 26.3.2011 6. Spektrum der Osteoporosetherapie. MSD Conference Days 2011, St. Wolfgang, Oberösterreich, 2.4.2011 7. Update in der Osteoporose. Qualitätszirkel der gynäkologischen Kassenärzte, St. Pölten, 2.5.2011
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8. PROLIA – der neue Therapieansatz in der Osteoporose, 6. gemeinsamer österreichisch-deutscher Geriatriekongress Autonomie, Wien, 12.5.2011 9. Pathophysiologie des Knochenstoffwechsels – Genetik der Osteoporose. Zertifizierungskurs I – Osteoporose als wichtigste osteologische Erkrankung, Wien, 17.6.2011 10. Kalzium, Vitamin D und Derivate. Zertifizierungskurs I – Osteoporose als wichtigste osteologische Erkrankung, Wien, 17.6.2011 11. Epidemiologie und Pathophysiologie der Osteoporose. Jahrestagung 2011 der Österreichischen Gesellschaft für Pneumologie (ÖGP), Messe Wien, 9.9.2011 12. Osteoimmunologie. 42. Jahrestagung Innere Medizin mit Herz, Innsbruck, 6.10.2011 13. Kardiovaskuläres System und Knochen: Molekulare Grundlagen, 42. Jahrestagung Innere Medizin mit Herz, Innsbruck, 7.10.2011 14. Pathophysiologie und Differentialdiagnose der Osteoporose, 42. Jahrestagung Innere Medizin mit Herz, Innsbruck, 7.10.2011 15. Osteoporosetherapie der Geriatrie – eine interdisziplinäre Herausforderung, 1. Novartis Geriatrieforum, Irdning, 16. Oktober 2011 16. Aging of Bone. 5.International Scientific and Educational Osteological Symposium. 1. Symposium of Bioregenerative Medicine in Slovakia, Bratislava, Slowakei, 10. November 2011 17. Osteoporose – Bewährtes und neue Therapieoptionen. ÖAK Diplomlehrgang Geriatrie, Akademie der Ärzte, Wien, 12. November 2011 18. Regulationsmechanismen und Pathophysiologie des Knochens. Bone Academy: Neue Ansätze in der Osteoporosetherapie beim geriatrischen Patienten, Wien, 12. November 2011 19. Metabolische Knochenerkrankungen beim geriatrischen Patienten. Masterlehrgang Geriatrie WS 2011/SS2012, Modul B: Klinische Geriatrie. Haus der Barmherzigkeit, 16. November 2011 20. Generation von Osteoklasten und Osteoblasten. Wissenschaftliche Herbsttagung 2011, Wien, 26. November 2011 21. Osteoporose beim Mann – ein Blick in den männlichen Knochen. Die TOMIBA- Studie: Hintergrund und Studiendesign. Wissenschaftliche Herbsttagung 2011, Wien, 26. November 2011
Renate Fuchs:
22. Characterization of human rhinovirus replication vesicles. 11th Hunter Meeting, Pokolbion, Australia, March, 22 – 25, 2011 23. Structure and function of the endocytic apparatus. Univ. Kinderklinik Gießen, Deutschland, October, 25-17, 2011
Theresia Thalhammer:
24. OATP transport proteins in liver, hepatic and extrahepatic tumors. ESF, Vorlesungsreihe, Palacky Univeristy Olomouc, Czech Republic, Department of Cell Biology and Genetics, May 3 – 5, 2011 25. OATP Transportproteine in hepatischen und extrahepatischen Tumoren. 13. Bad Herrenalber Transporter- und Barriere Tage, Germany, June 1, 2011
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26. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for pacltaxel transport (V07). Cesar Annual Meeting, University Greifswald, Germany, June 16-18, 2011 27. Members of the organic anion transporter family: Potential role in cancer progress. P.J. Safarik Univeristy, Kosice, June 20, 2011 28. OATP family members in ovarian cancer and their potential role in tumor therapy. 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine, Rhodos, Greece, October, 8, 2011 29. Arzneistoffmetabolismus - Grundlagen und klinische Anwendung (320067 VO). Sommersemester 2011, Department für Klinische Pharmazie und Diagnostik, Universität Wien
1.2.4. Congress organization
Division National congress Intern. member Name, date Function congress, Function Name: Name, date Isabella WISIA Symposium Interdisziplinäres organising Ellinger Symposium zur Vernetzung österreichischer committee Wissenschafterinnen aus Grundlagen- forschung, angewandter Forschung und Technik, Joanneum, Graz 03/04/2011–03/05/2011 Isabella WISIA Symposium Interdisziplinäres organising Ellinger Symposium zur Vernetzung österreichischer committee Wissenschafterinnen aus Grundlagen- forschung, angewandter Forschung und Technik, Medizinische Universität Wien 11/11/2011–11/12/2011 Peter Wissenschaftliche Herbsttagung 2011 der Congress Pietschmann Österreichischen Gesellschaft für Knochen co- und Mineralstoffwechsel, 11/25/2011– president 11/26/2011
1.2.5. Hosting speakers division member Speaker´s name Affiliation Date Isabella Ellinger Adolf Ellinger, Dept. Histol. Embryol. II/MedUniWien 01/21/2011 Theresia Thalhammer PhD Renate Fuchs Isabella Ellinger Tim Skern, PhD Dept. Medical Biochemistry, Univ. 201/28/2011 Peter Pietschmann Vienna Isabella Ellinger Alexander Seewald Solutions, Vienna 03/18/2011 Theresia Thalhammer Seewald, PhD Renate Fuchs Isabella Ellinger Andrea Kolbus, Technology Transfer, MedUniWien 04/08/2011 Theresia Thalhammer MD Renate Fuchs Isabella Ellinger Monika BOKU, VIBT Imaging center 05/13/2011 Theresia Thalhammer Debreczeny; MD and PhD
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Renate Fuchs Theresia Thalhammer Carsten Ehrhardt, School of Pharmacy and 09/30/2011 Dr. Pharmaceutical Sciences, Trinity College, Dublin, Ireland Theresia Thalhammer Lorenz Auer- Klinik für Dermatologie, MD 11/04/2011 Hackenberg, MD Anderson Cancer Center, Dallas, USA Isabella Ellinger Alexander Seewald Solutions, Vienna 11/25/2011 Theresia Thalhammer Seewald, PhD Renate Fuchs Peter Pietschmann Theresia Thalhammer Simin Tavooni Tehran University of Medical 12/09/2011 Sciences, Teheran, Iran Isabella Ellinger Herbert Juch, MD Dept. Cell Biol., Histol. and Embryol., 12/16/2011 Theresia Thalhammer Medical University Graz Renate Fuchs Peter Pietschmann
1.2.6. Mobility
Name Program University, country Time frame Division In Out Molcan Lubos Ernst-Mach- Comenius University, 10/01/2011- 2 x Stipendium der Faculty of Sciences, 01/31/2012 Aktion Department of Animal Österreich- Physiology and Ethology, Slowakei Bratislava, Slovakia Danka Erasmus Medical University of Sofia, 04/10/2011 – 2 x Obreshkova, Programme Department of 04/15/2011 Dr. Pharmacological Chemistry, Faculty of Pharmacy, Bulgaria Irena Kostova Erasmus Medical University of Sofia, 04/10/2011 – 2 x Programme Department of 04/15/2011 Pharmacological Chemistry, Faculty of Pharmacy, Bulgaria
1.2.7. Activities in Advisory Boards
Name Society/Institute/Journal Function Pietschmann Peter Habilitationskommission Mitglied der Kommission “konservativ I” (Interne, Pädiatrie, Dermatologie, Radiologie) Pietschmann Peter Bundesministerium für Beirat für Altersmedizin Gesundheit
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1.2.8. Editorial Activities
Name Journal Function Pietschmann Peter Wiener Medizinische Associate Editor Wochenschrift
Pietschmann Peter Hormone Metabolic Research Member Editorial Board
Pietschmann Peter Zeitschrift für Geriatrie und Member Editorial Board Gerontologie
Pietschmann Peter Journal für Mineralstoffwechsel Member Editorial Board
1.2.9. Review Activities
Name Grants/Thesis/Habilitation Peter Pietschmann Deutsche Forschungsgemeinschaft (Grant) Peter Pietschmann Jubiläumsfonds der Österr. Nationalbank (Grant) Peter Pietschmann Veterinärmedizinische Universität Wien (Doctoral Thesis) Theresia Thalhammer Jubiläumsfonds der Österr. Nationalbank (Grant) Theresia Thalhammer Medizinisch-Wissenschaftlicher Fonds des Bürgermeisters der Bundeshauptstadt Wien (Grant) Theresia Thalhammer ÖAD (Grant) Theresia Thalhammer Slovak Academia of Sciences (grant)
1.2.10. Filed and granted patents
Name Patent Isabella Ellinger “Metastrukturen in Geweben” Patent Nr. 1444/2010
1.2.11. Grants
Funding agency Title of project Principal investigator FWF, doctoral Cathepsin S: ein Modulator in der Osteoimmunologie Peter Pietschmann college, CCHD Österreichische Vergleichsstudie von Hüftkopfknochen von Männern Peter Pietschmann National Bank Schenkelhalsfrakturen bzw. Hüftarthrosen
Krankenhaus der Microarchtitecture of bone in osteoporotic men: the Peter Pietschmann Barmherzigen association between osteoblastic gene expression patterns Schwestern and treatment effects II.Medizinische Abteilung (Prim.Univ.Prof. H. Resch) Springer Verlag Unterstützung der Errichtung und Betreibung eines Editorials Peter Pietschmann GmbH Office für die Wiener Medizinische Wochenschrift und der Publikationstätigkeit der Arbeitsgruppe Knochen-, Gender- und Altersforschung
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SERVIER & ADIR Strontium ranelate effect on osteoblast-induced differentiation Peter Pietschmann and activity through the modulation of RANKL Roche Austria Errichtung eines Forschungsnetzwerks auf dem Gebiet der Peter Pietschmann GmbH Gerontologie Vinforce Research Network Osteology – Gene Expression Substudy. Peter Pietschmann Amgen Cathepsin S in Osteoimmunology: additional studies Peter Pietschmann MSD – Merck, Cathepsin K in Osteoimmunology Peter Pietschmann Sharp & Dohme FFG Bridge Automatisierte Zellerkennungs-Technologien für Forschung Isabella Ellinger, Co- und Diagnose Applicant: Theresia Thalhammer, Giovanna Bises
FFG IgG-Lokalisation – generation innovation Praktika, Talente Isabella Ellinger Praktika für Schülerinnen und Schüler (Michaela Jungmann) FFG FcRN-Lokalisation generation innovation Praktika (Talente Isabella Ellinger Praktika für Schülerinnen und Schüler (Stefan Grbic) Medizinisch- Proteins of the family of “organic anion transporters (OATP) Theresia Thalhammer wissenschaftlicher and their potential role in lung and colon cancer therapy. (Cooperation:Dr. Buxhofer- Fonds des Ausch, SMZ-Ost) Bürgermeisters der Stadt Wien Medizinisch- Identifikation und Validation therapeutischer Targets beim Principle Investigator: wissenschaftlicher kleinzelligen Lungenkarzinom Theresia Thalhammer Fonds des (Cooperation Univ.Prof.Dr. Bürgermeisters der Primar Klaus Geissler, Stadt Wien Ludwig Boltzmann Institut, KH Hitzing, 5. Med. Abt. mit Onkologie
1.2.12. Career Developments a) Habilitations: n = 1
Priv.Doz.Dr. Arno Wutzl (supervised in part by Peter Pietschmann) b) Habilitations in progress: n = 0 c) Professorships: n = 0
1.2.13. Teaching a) Bachelor students: n = 5 practical training:
Renate Fuchs:
Kristina Todtova, FH Campus Vienna, Bachelor study: Molecular Biotechnology, Jan 10 – June 30, 2011
Isabella Ellinger:
Julia Mytsko, FH Campus Vienna, Bachelor study: Molecular Biology, Feb, 1 – May 31, 2011
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Theresia Thalhammer:
Felicitas Mungenast, FH Campus Vienna, Bachelor study: Molecular Biotechnology, Jan 10 – June 30, 2011 Florian Schadauer, FH Campus Vienna, Bachelor study: Molecular Biotechnology, Jan 10 – June 30, 2011 Madeleine Schölm, FH Campus Vienna, Bachelor study: Moleculra Biotechnology, Jan 10 – June 30, 2011 b) Diploma, MDiploma and Master students: n = 22
Renate Fuchs:
Jalali Manuel: MDiploma Thesis. Mechanismus von Virusinfektionen: Einfluß von Ethylisopropylamilorid auf die Infektion von HRB89. (07/2011 – in progress). Medical University of Vienna Spanberger Thomas: MDiploma Thesis. Mechanismus von Virusinfektionen. (05/2009 – in progress), Medical University of Vienna.
Peter Pietschmann:
Bogdan Cosmina: MDiploma Thesis. Histomorphometrische Analysen in einem experimentellen Modell zur Therapie der Osteoporose. (01/2009 – 10/2011), Medical University of Vienna. Diebler Julian: MDiploma Thesis. Effekte verschiedener BMP-Kombinationen auf murine Osteoklasten und Osteoblasten in der Zellkultur (11/2011 – in progress). Medical University of Vienna Kurz Michael: MDiploma Thesis. Knochenveränderungen bei Cathepsin S Knockout-Mäusen. (01/2010 – in progress), Medical University of Vienna Mayr Helene: MDiploma Thesis. Knochenhistomorphometrie bei einer experimentellen Osteoporosetherapie. (01/2009 – in progress), Medical University of Vienna. Mukaddam Sena: MDiploma Thesis. Knochenstruktur bei Morbus Paget: Analyse von historischen Knochenmaterial mittels HRpQCT (10/2008 – in progress). Medical University of Vienna Ortner Nadine: Diploma Microbiology and Immunology. Osteomacrophages in cathepsin S knock out mice (11/2011 – in progress) University of Vienna. Sillipp Josef: MDiploma Thesis. Development and evaluation of an automatic method for bone histomorphometry. (05/2010 – in progress). Medical University of Vienna
Theresia Thalhammer:
Awad Madonna: DiplomaGenetic. OATP-Proteine in soliden Tumoren (04/2011 – in progress) University of Vienna
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Burger Kathrin: DiplomaPharm Thesis. Einfluß von Melatonin auf das Wachstum von Osteoklasten: Untersuchungen mittels eines neuen automatisierten Imageanalysesystems. (09/2010 – in progress). University of Vienna. Durmaz Yasemin: DiplomaPharm Thesis. Expression von Enzymen und Transportproteinen in Tumorzellen und Geweben: Bedeutung für die Therapie. (09/2011 – in progress). University of Vienna Eskandari Hamidreza: MDiploma thesis: Studies on the expression of organic anion transport polypeptides in human cell lines (11/2008 – in progress), Medical University of Vienna. Gründsteidel Johann: MDiploma thesis: Prostaglandin transporting OATPs in ovarian cancer. (10/2010 – in progress). Medical University of Vienna Kalayci Dilek: DiplomaPharm Thesis. Bestimmung von OATP-Transportern in Tumorzellen: Bedeutung für die Aufnahme von Zytostatika. (03/2011 – 12/2011). Univeristy of Vienna Ndue Leonard: MDiploma. Prostaglandin-Homöostase beim Ovarialkarzinom – Rolle von COX-2 (07/2011 – in progress). Medical University of Vienna
Sanlioglu Cihangül: DiplomaPharm Thesis. Expression von Transportproteinen in humanen Tumorgewebe. (03/2010 – 12/2011). University of Vienna. Sultan Sirag: MDiploma: Prostaglandin-Homöostase beim Ovarialkarzinom – Rolle des Prostaglandintransporters OATP2A1 (07/2011 – in progress). Medical University of Vienna Türkay Emel: MDiploma thesis. Expression of the transporter OATP 5A1 in normal and malignant human tissue. (11/2008 – in progress), Medical University of Vienna. Zakaria Susanna: DiplomaPharm Thesis. Proteins of the family of „organic anion transporters (OATP)“ and their potential role in lung and colon cancer therapy. (09/2010 – in progress). University of Vienna. Zaussinger Siliva: DiplomaPharm Thesis. Charakterisierung eines neuen OATPs (LS-3TM12) in Lebertumoren: Bedeutung für die Tumortherapie. (09/2010 – in progress). University of Vienna. Zhang Wenyi: MDiploma thesis.Prostaglandin-Homöostase beim Ovarialkarzinom – Rolle des Transporters MRP4. (05/2011 – in progress). Medical University of Vienna c) PhD, MDSci, MD students: n = 8
Isabella Ellinger:
Heindl Andreas, Dipl.Ing: PhD Thesis. Automated cell detection technologies for science and diagnostics (03/2009-in progress), Medical University of Vienna
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Ehresheim Christine, Mag: PhD Thesis. Characterization of the Reelin/Thrombospondin/ApolipoproteinE Receptor2/very low density lipoprotein receptor – signalling pathways in granulosa cells. (08/2010 – in progress), Medical University of Vienna.
Peter Pietschmann:
Azizi-Semrad Ursula: MD Thesis. Extended cytokine profiling of functional human peripheral blood CD4+ T lymphocytes (Th1, Th2 and Th17) and the effect of different micro-environments on their differentiation. (11/2007 – in progress). Medical University of Vienna. Patsch Janina, Dr.med.: PhD Thesis. Gene expression, bone microarchitecture and treatment effects in male osteoporosis (01/2007 – 11/2011. Medical University of Vienna. Maldonado-Gonzalez Eduardo: PhD Thesis. The role of Serotonin transporter (5-HTT) and insulin degrading enzyme (IDE) Polymorphism in vascular diseases (05/2011 – in progress(. Medical University of Vienna.
Theresia Thalhammer:
Terezia Kiskova: PhD Thesis. Physiology of animal sciences – studies on chemical induced breast cancer in rats. (02/2011 – in progress) Pavol Jozef Safárik University, Kosice
Rentsen Erdentetsetseg: PhD Thesis. Identifikation und Validation therapeutischer Targets beim kleinzelligen Lungenkarzinom. (11/2011 – in progress) Medical University of Vienna Riha Juliane, Mag.pharm: PhDPharm Thesis. Metebolismus und Transport neuer Zytostatika in humanen Tumorzelllinien in Gewebe (10/2009 – in progress), University of Vienna.
Trainee:
Isabella Ellinger:
GRBIC Stefan, Academy of Chemical Industry, July 4 – 29, 2011 JUNGMANN Michaela, Academy of Chemical Industry, July 4 – 29, 2011
1.2.14. Exams a) Oral examinations: n = 3 b) Diploma and Thesis-Examinations: n = 9
Peter Pietschmann
Mag. Karoline Reich, Thesis Examination of Applied Medical Sciences, 20.4.2011 Thomas Puntus, Diploma Examination of Human Medicine, 22.6.2011 Dr. Janina Patsch, PhD Doctoral Thesis Examination, 22.11.2011 Gerd Pfingstner, Dentistry Diploma Examination, 27.7.2011 Stefanie Salzl, Dentistry Diploma Examination, 27.7.2011
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Renate Fuchs
Sonja Lottermoser, MD Diploma Thesis Examination, 21.11.2011 Dorian Jungmann, MD Diploma Thesis Examination, 29.11.2011
Theresia Thalhammer Lorenz Auer-Hackenberg, Diploma Examination of Human Medicine, 12.10.2011 Bernhard Giessrigl, Doctoral Thesis Examination Pharmacy, University of Vienna, 17.11.2011 c) Exam supervising: n = 4
Isabella Ellinger: SSM 2, 11/03/2011 SIP 2, 30/06/2011
Renate Fuchs: Komm. SIP1, 05/05/2011 Komm. SIP1, 22/09/2011 d) Reviewing of Doctoral Thesis: n = 1
Peter Pietschmann, Review of Doctoral Thesis, University of Veterinary Medicine
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1.2.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2011 Pietschmann Peter 2.00 0.08 860.074 JC Endocrinology and Metabolism "SS11 (Pflichtfach) Pietschmann Peter 2.00 0.13 870.201 Propedeutics in Human Medicine II - Physiology Pietschmann Peter 2.00 0.13 860.220 Basisvorlesung Immunologie Pietschmann Peter 1.00 1.00 860.034 Journal Club (N090, N094, and N0790) Pietschmann Peter 2.53 0.40 804.000 BL 10 - Endokrinologie und Stoffwechsel Pietschmann Peter 2.27 0.47 806.021 SSM 2 - Methoden der zellulären Pathophysiologie Dissertantenseminar: Durchflusszytometrie - Methodik und immunologische Pietschmann Peter 2.00 0.70 860.302 Anwendungsmöglichkeiten Pietschmann Peter 2.00 2.00 648.018 Experimentelle Arbeitstechniken in der Osteologie Ellinger Isabella 1.00 0.33 860.034 Journal Club (N090, N094, and N0790) Ellinger Isabella 2.00 0.66 860.036 Journal Club and Progress Report Ellinger Isabella 2.27 0.68 806.021 SSM 2 - Methoden der zellulären Pathophysiologie Thalhammer Theresia 1.00 0.33 806.009 Ärztliche Gesprächsführung B Thalhammer Theresia 2.00 0.66 860.036 Journal Club and Progress Report Thalhammer Theresia 4.00 1.00 808.004 SSM 3-Projektstudie (Wahlpflichtteil) Thalhammer Theresia 5.00 5.00 514032 Wissenschaftliche Arbeiten – Pathophysiologie der Wirkung von Umweltgiften, SE Fuchs Renate 4.00 0.50 808.004 SSM 3-Projektstudie (Wahlpflichtteil) Fuchs Renate 2.00 0.66 860.036 Journal Club and Progress Report Fuchs Renate 2.27 0.68 806.021 SSM 2 - Methoden der zellulären Pathophysiologie
Sum 15.41 WS 2011/12 Pietschmann Peter 5,00 0,50 514.053 Anleitung zu wissenschaftlichen Arbeiten - (Wahlfachausbildung gem. § 13/1 lit.a StG.) Pietschmann Peter 2,00 2,00 648.801 Experimentelle Arbeitstechniken in der Osteologie Dissertantenseminar: Durchflusszytometrie - Methodik und immunologische Pietschmann Peter 2,00 0,70 653.346 Anwendungsmöglichkeiten Pietschmann Peter 5,80 0,40 803.002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Pietschmann Peter 4,27 0,27 807.002 02BL 21 - Bewegung und Leistung Pietschmann Peter 6,10 1,33 825.001 BL Z-1 Kau- und Bewegungsapparat Pietschmann Peter 1,00 0,33 860.011 Creative and critical Journal Club I
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Pietschmann Peter 2,00 0,50 860.020 Journal Club and Progress Report I Pietschmann Peter 2,00 0,07 860.937 Basic Seminar "Endocrinology and Metabolism I" (Wahlpflichtfach) Nummer 860.937 Pietschmann Peter 3,00 0,21 896.006 Gender - Basics in Gender Medizin 1 Pietschmann Peter 2,00 0,10 902.005 Basic Seminar Ellinger Isabella 1.13 3.07 801001 BL 1 – Gesunde und kranke Menschen, SK Ellinger Isabella 1.07 0.8 801004 BL 2 – Der menschliche Körper, SK Ellinger Isabella 1.73 1.87 801006 BL 3 – Vom Molekül zur Zelle, SK Ellinger Isabella 0.50 1.00 803001 BL 7 – Wissenschaft und Medizin (SSM 1), SK Ellinger Isabella 2.50 2.50 803074 SSM1-Entstehung von AGEs und ihre Rolle bei chronischen Erkrank.. Ellinger Isabella 1.00 0.34 860011 JC Creative an critical Journal Club, SE Ellinger Isabella 2.00 0.5 860020 Journal Club and Progress Report, SE Thalhammer Theresia 2.00 0.66 860020 Journal Club and Progress Report, SE Thalhammer Theresia 5.00 5.00 514032 Wissenschaftliches Arbeiten – Pathophysiologie der Wirkung von Umweltgiften Fuchs Renate 2.00 0.07 562019 BVo: Immunologie, VO Fuchs Renate 1.13 2.93 801001 BL 1 – Gesunde und kranke Menschen, SK Fuchs Renate 6.27 1.13 801005 BL 3 – Vom Molekül zur Zelle, VO Fuchs Renate 1.73 4.27 801006 BL 3 – Vom Molekül zur Zelle, SK Fuchs Renate 2.50 2.50 803051 SSM 1 – Mechanismus von Virusinfektionen, SE Fuchs Renate 2.27 0.53 805002 BL 14 – Niere und Homöostase, VO Fuchs Renate 2.00 0.50 860020 Journal Club and Progress Report I, SE Sum 34.08 Total sum SS+WS 49.49
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1.3 Division for Immunopathology Head: Rudolf Valenta, MD, Professor
1. Publications6 IF Number Top/Std/Subst Rudolf Valenta 161.919 27 23 Top, 4 St. Beatrice Jahn-Schmid 32.823 5 4 Top, 1 St. Bohle Barbara 75.411 14 10 Top, 4 St. Margit Focke-Tejkl 77.617 14 11 Top,3 St. Ines Swoboda 41.616 8 5 Top, 3 St Susanne Vrtala 10.683 3 2 Top, 1 St. Sabine Flicker 20.358 4 4 Top, 0 St. Sum 420.427 75 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2
2. Supervision of bachelor, diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Rudolf Valenta 1 3 8 Beatrice Jahn-Schmid 0 0 0 Bohle Barbara 0 5 6 Margit Focke-Tejkl 0 1 0 Ines Swoboda 0 0 0 Susanne Vrtala 0 0 5 Sabine Flicker 0 0 2 Sum 1 9 21
3. Teaching SS* WS* total W+S oral Exams Rudolf Valenta 14.72 15.13 29.85 Beatrice Jahn-Schmid 0.00 3.00 3.00 1 Bohle Barbara 9.39 7.66 17.05 7 Margit Focke-Tejkl 1.00 0.50 1.5 0 Ines Swoboda 14.00 5.00 19.00 0 Susanne Vrtala 1.00 0.50 1.50 3 Sabine Flicker 0.50 1.00 1.5 1 Sum 40.61 32.79 73.40 12
6 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 51
Performance Report 2011 Immunopathology
1.3.1. Publications a) Peer-reviewed original articles: n=37
Nr. Article IF Class 1. Heratizadeh, A.*, I. Mittermann, H. Balaji, K. Wichmann, R. 1 4.353 Top . Valenta, and T. Werfel. 2011. The role of T-cell reactivity towards the autoantigen α-NAC in atopic dermatitis. Br. J. Dermatol. 164:316-324. 2. Reginald, K., K. Westritschnig, T. Werfel, A. Heratizadeh, N. 2 4.195 Top . Novak, M. Focke-Tejkl, A. M. Hirschl, D. Y. M. Leung, O Elisyutina, E. Federenko, and R. Valenta*. 2011. Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients. Clin. Exp. Allergy. 41:357-369. 3. Campana, R., S. Vrtala, B. Maderegger, Y. Dall´Antonia, D. 3 2.916 St. . Zafred, K. Blatt, H. Herrman, M. Focke-Tejkl, I. Swoboda, S. Scheiblhofer, A. Gieras, A. Neubauer, W. Keller, P. Valent, J. Thalhamer, S. Spitzbauer, and R. Valenta*. 2011. Altered IgE epitope presentation: a model for hypoallergenic activity revealed for Bet v 1 trimer. Mol. Immunol. 48:431-441. 4. Madritsch, C., S. Flicker, S. Scheiblhofer, J. Thalhamer, and 4.195 Top R. Valenta*. 2011. Recombinant monoclonal human immunoglobulin E to investigate the allergenic activity of major grass pollen allergen Phl p 5. Clin Exp Allergy. 41:270-280. 5. Vrtala, S., M. Fohr, C. Baumgartner, R. Campana, P. Valent, 3.572 Top and R. Valenta*. 2011. Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination. Vaccine. 29:2140-2148. 6. Edlmayr, J., K. Niespodziana, T. Popow-Kraupp, V. 5.922 Top Krzyzanek, M. Focke-Tejkl, D. Blaas, M. Grote, and R. Valenta*. 2011. Antibodies induced with recombinant VP1 from Human Rhinovirus exhibit cross-neutralization. Eur Respir J. 37:44-52. 7. Bousquet, J.*, J. Anto, C. Auffray, M. Akdis, A. Cambon- 6.297 Top Thomsen, T. Keil, T. Haahtela, B. N. Lambrecht, D. S. Postma, J. Sunyer, R. Valenta, C. A. Akdis, I. Annesi- Maesano, A. Arno, C. Bachert, F. Ballester, X. Basagana, U. Baumgartner, C. Bindslev-Jensen, B. Brunekreef, K. H. Carlsen, L. Chatzi, R. Crameri, E. Eveno, F. Forastiere, J. Garcia-Aymerich, S. Guerra, H. Hammad, J. Heinrich, D. Hirsch, B. Jacquemin, F. Kauffmann, M. Kerkhof, M. Kogevinas, G. H. Koppelman, M. L. Kowalski, S. Lau, K. C. Lodrup-Carlsen, M. Lopez-Botet, J. Lotvall, C. Lupinek, D. Maier, M. J. Makela, F. D. Martinez, J. Mestres, I. Momas, M. C. Nawijn, A. Neubauer, S. Oddie, S. Palkonen, I. Pin, C. Pison, F. Rancé, S. Reitamo, E. Rial-Sebbag, M. Salapatas, V. Siroux, D. Smagghe, M. Torrent, E. Toskala, P. van Cauwenberge, A. J. M. van Oosterhout, R. Varraso, L. von Hertzen, M. Wickman, C. Wijmenga, M. Worm, J. Wright, and T. Zuberbier. 2011. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to system medicine. Allergy. 66:596-604. 8. Gallerano, D., S. C. Devanaboyina, I. Swoboda, B. Linhart, 4.106 St. I. Mittermann, W. Keller, and R. Valenta*. 2011. Biophysical
52 Performance Report 2011 Immunopathology
characterization of recombinant HIV-1 subtype C virus infectivity factor. Amino Acids. 40:981-989. 9. Arkestål, K., E. Sibanda, M. Troye-Blomberg, R. Valenta, H. 9.273 Top Grönlund, and M. van Hage*. 2011. Impaired allergy diagnostics among parasite infected patients caused by IgE antibodies to the carbohydrate epitope galactose-α1,3- galactose. J. Allergy Clin. Immunol. 127:1024-1028. 10. Curin, M., Swoboda, M. Focke-Tejkl, R. Valenta*, and S. 2.235 St. Spitzauer. 2011. Skin Prick Test extracts for dog allergy diagnosis show considerable variations regarding the content of major and minor dog allergens. Int. Arch. Allergy Immunol. 154:258-263. 11. Gieras, A., P. Cejka, K. Blatt, M. Focke-Tejkl, B. Linhart, S. 5.745 Top Flicker, A. Stoecklinger, K. Marth, A. Drescher, J. Thalhamer, P. Valent, O. Majdic, and R. Valenta*. 2011. Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet. v 1. J. Immunol. 186:5333-5344. 12. Niespodziana, K., B. Linhart, M. Focke-Tejkl, V. Civaj, K. 9.273 Top Blatt, P. Valent, M. van Hage, H. Grönlund, and R. Valenta*. 2011. A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS. J. Allergy Clin. Immunol. 127:1562-1570. 13. Gadermaier, E., J. Staikuniene, S. Scheiblhofer, J. 6.297 Top Thalhamer, M. Kundi, K. Westritschnig, I. Swoboda, S. Flicker*, and R. Valenta. 2011. Recombinant allergen-based monitoring of antibody responses during injection grass pollen immunotherapy and after 5 years of discontinuation. Allergy. 66:1174-1182. 14. Korošec, P.*, R. Valenta, I. Mittermann, N. Celesnik, R. 9.273 Top Eržen, M. Zidarn, and M. Košnik. 2011. Low sensitivity of commercially available rApi m 1 for diagnosis of honeybee venom allergy. J. Allergy Clin. Immunol. 128:671-673. 15. Reginald, K., K. Westritschnig, B. Linhart, M. Focke-Tejkl, 9.273 Top B. Jahn-Schmid, A. Heratizadeh, A. Stöcklinger, N. Balic, S. Spitzauer, T. Werfel, J. Thalhamer, A. M. Hirschl, and R. Valenta*. 2011. Staphylococcus aureus fibronectin-binding protein specifically binds IgE from patients with atopic dermatitis and requires antigen presentation for cellular immune responses. J. Allergy Clin. Immunol. 128:82-91. 16. Twaroch, T. E., M. Focke-Tejkl, V. Civaj, N. Balic, A. Mari, S. 9.273 Top Quirce, S. Spitzauer, R. Valenta, and I. Swoboda, R. Valenta*. 2011. Carrier-bound, nonallergenic Ole e 1 peptides for vaccination against olive pollen allergy. J. Allergy Clin. Immunol. 128:178-184. 17. Baranyi, U., M. Gattringer, A. Boehm, K. Marth, M. Focke- 2.235 St. Tejkl, B. Bohle, P. Valent, R. Valenta, and T. Wekerle*. 2011. Expression of a major plant allergen as membrane-anchored and secreted protein in human cells with preserved allergenic activity. Int. Arch. Allergy Immunol. 156:259-266, DOI 10.1159/000323733. 18. Hochwallner, H., U. Schulmeister, I. Swoboda, T. Twaroch, 6.297 Top H. Vogelsang, L. Kazemi-Shirazi, M. Kundi, N. Balic, S. 53 Performance Report 2011 Immunopathology
Quirce, H. Rumbold, R. Fröschl, F. Horak, B. Tichatschek, C.L. Stefanescu, Z. Szepfalusi, N. G. Papadopoulos, A. Mari, C. Ebner, G. Pauli, R. Valenta*, and S. Spitzauer. 2011. Patients suffering from non-IgE-mediated cow´s milk protein intolerance cannot be diagnosed based on IgG subclass or IgA responses to milk allergens. Allergy. 66:1201-1207. 19. Resch, Y., M. Weghofer, S. Seiberler, F. Horak, S. 4.195 Top Scheiblhofer, B. Linhart, I. Swoboda, W. R. Thomas, J. Thalhamer, R. Valenta, and S. Vrtala*. 2011. Molecular characterization of Der p 10: A diagnostic marker for broad sensitization in house dust mite allergy. Clin. Exp. Allergy. 41:1468-1477. 20. Dall`Antonia, F., A. Gieras, R. Valenta, and W. Keller*. 2011. 9.273 Top Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity. J. Allergy Clin. Immunol. 128:872-879.e8. 21. Renz, H*., I. B. Autenrieth, P. Brandtzæg, W. O. Cookson, S. 9.273 Top Holgate, E. von Mutius, R. Valenta, and D. Haller. 2011. Gene-environment interaction in chronic disease: A European Science Foundation forward look. J. Allergy Clin. Immunol. 128:S27-49. 22. Valenta, R. and R. L. Coffman. 2011. Current strategies for 4.121 Top allergen-specific immunotherapy at its centenary. Curr. Top. Microbiol. Immunol. 352: v-vi. 23. Schmetterer, K. G., D. H. Haiderer, V. M. Leb-Reichl, A. 9.273 Top Neunkirchner, B. Jahn-Schmid, H. J. Küng, K. Schuch, P. Steinberger, B. Bohle and W. F. Pickl. Bet v 1-specific TCR/Foxp3 double tg T-cells suppress the effector function of Bet v 1-specific T-cells in an activation dependent manner. J. Allergy Clin. Immunol.,2011, 127: 238-245e, DOI: 10.1016/j.jaci.2010.10.023 24. Neunkirchner, A., V. M. Leb-Reichl, K.G. Schmetterer, S. 5.745 Top Mutschlechner, H. J. Kueng, D. Haiderer, K. Schuch, M. Wallner, B. Jahn-Schmid, B. Bohle, and W. F. Pickl. Human TCR transgenic Bet v 1-specific Th1 cells suppress the effector function of Bet v 1-specific Th2 cells. J. Immunol., 2011, 187:4077-4087, DOI: 10.4049/jimmul.1003220 25. Niespodziana K, Napora K, Cabauatan C, M. Focke-Tejkl, 6.515 Top Keller W, Niederberger V, Tsolia M, Christodoulou I, Papadopoulos NG, Valenta R. Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections. FASEB J. 2011 Nov 25. 26. Sturm GJ, Jin C, Kranzelbinder B, Hemmer W, Sturm EM, 4.411 Top Griesbacher A, Heinemann A, Vollmann J, Altmann F, Crailsheim K, M. Focke-Tejkl, Aberer W. Inconsistent results of diagnostic tools hamper the differentiation between bee and vespid venom allergy. PLOS One. 2011;6:e20842 27. Konakovsky V*, M. Focke-Tejkl *, Hoffmann-Sommergruber 2.230 Top K, Schmid R, Scheiner O, Moser P, Jarisch R, Hemmer W. Levels of histamine and other biogenic amines in high-quality red wines. Food Addit Contam A. 2011;28:408-16. 28. Geroldinger-Simic, M., Zelniker, T., Aberer, W., Ebner, C., 9.273 Top Egger, C., Greiderer, A., Prem, N., Lidholm, J., Ballmer- 54 Performance Report 2011 Immunopathology
Weber, B.K., Vieths, S. and Bohle, B. Birch pollen-related food allergy: clinical aspects and the role of allergen-specific IgE and IgG4 antibodies. J Allergy Clin Immunol, 2011, 127:616-622 e1; DOI: 10.1016/j.jaci.2010.10.027 29. Schulten, V., I. Lauer, S. Scheurer, T. Thalhammer, and B. 4.713 Top Bohle. A food matrix reduces digestion and absorption of food allergens in vivo. Mol Nutr Food Res, 2011, 55:1484-1491; DOI: 10.1002/mnfr.201100234 30. Schulten, V., Nagl, B., Scala, E., Bernardi, M.L., Mari, A., 6.297 Top Ciardiello, M.A., Lauer, I., Scheurer, S., Briza, P., Jurets, A., Ferreira, F., Jahn-Schmid, B., Fischer, G.F. and Bohle, B. Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. Allergy. 2011, 66:1005-1013; DOI: 10.1111 31. Wallner, M., Hauser, M., Himly, M., Zaborsky, N., 9.273 Top Mutschlechner, S., Harrer, A., Asam, C., Pichler, U., van Ree, R., Briza, P., Thalhamer, J., Bohle, B., Achatz, G. and Ferreira, F. Reshaping the Bet v 1 fold modulates T(H) polarization. J Allergy Clin Immunol. 2011, 127:1571-1578 e9; DOI: 10.16/j.jaci.2011.01.064 32. Varga, E.M., Kollmann, D., Zach, M. and Bohle, B. 2.235 St. Anaphylaxis to Buckwheat in an Atopic Child: A Risk Factor for Severe Allergy to Nuts and Seeds? Int Arch Allergy Immunol. 2011, 156:112-116; DOI: 10.1159/000321916 33. Van Hemelen, D., Oude Elberink, J.N., Bohle, B., Heimweg, 2.340 St. J., Nawijn, M.C. and van Oosterhout, A.J. Flow cytometric analysis of cytokine expression in short-term allergen- stimulated T cells mirrors the phenotype of proliferating T cells in long-term cultures. J Immunol Methods, 2011, 371:114- 121; DOI:10.1016/j.Jim.2011.06.019 34. Toda, M., Reese, G., Gadermaier, G., Schulten, V., Lauer, I., 9.273 Top Egger, M., Briza, P., Randow, S., Wolfheimer, S., Kigongo, V., Del Mar San Miguel Moncin, M., Fotisch, K., Bohle, B., Vieths, S. and Scheurer, S. Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen. J Allergy Clin Immunol; 2011, 128:1022-30.e1-7; DOI: 10.1016/j.jaci.2011.04.020 35. Ilk, N., Schumi, C.T., Bohle, B., Egelseer, E.M. and Sleytr, 4.544 Top U.B. Expression of an endotoxin-free S-layer/allergen fusion protein in gram-positive Bacillus subtilis 1012 for the potential application as vaccines for immunotherapy of atopic allergy. Microb Cell Fact. 2011, 10:6; DOI: 101186/1475-2859-10-6 36. Egger, M., Jurets, A., Wallner, M., Briza, P., Ruzek, S., Hainzl, 4.411 Top S., Pichler, U., Kitzmuller, C., Bohle, B., Huber, C.G. and Ferreira, F. Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome. PLoS One. 2011, 6:e17278; DOI: 10.1371/journal.pone.0017278 37. Cejka, D., Jager-Lansky, A., Kieweg, H., Weber, M., 3.564 Top Bieglmayer, C., Haider, D.G., Diarra, D., Patsch, J., Kainberger, F., Bohle, B. and Haas, M. Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients. Nephrol Dial Transplant; 2011, DOI:10.1093/ndt/gfr270 sum 215.689
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1.b) Invited Articles & Reviews with IF: n=6
Nr. Article IF Class 1. Flicker, S., E. Gadermaier, C. Madritsch, and R. Valenta. 1 4.121 T Passive. immunization with allergen-specific antibodies. 2011. Curr Top Microbiol Immunol 352:141-59. 2. Jahn-Schmid, B., W. Pickl and B. Bohle. Interaction of 2 2.235 St. Alle. rgens, Major Histocompatibility Complex Molecules, and T Cell Receptors: A Ménage à Trois That Opens New Avenues for Therapeutic Intervention in Type I Allergy. Int. Arch. Allergy Immunol., 2011, 156:27-42, DOI: 10.1159/000321904 3. Edlmayr, J., K. Niespodziana, M. Focke-Tejkl, B. Linhart, 3 4.121 T. and. R. Valenta*. 2011. Allergen-specific immunotherapy: towards combination vaccines for allergic and infectious diseases. Curr. Top. Microbiol. Immunol. 352:121-140. 4. Valenta, R.*, B. Linhart, I. Swoboda, and V. Niederberger. 6.297 T 2011. Recombinant allergens for allergen-specific immunotherapy: 10 years anniversary of immunotherapy with recombinant allergens. Allergy. 66:775-783. 5. Baranyi, U., M. Gattringer, R. Valenta, and T. Wekerle*. 4.121 T 2011. Cell-based therapy in allergy. Curr. Top. Microbiol. Immol. 352:161-179. 6. Valenta, R.*, M. Focke-Tejkl, K. Niespodziana, K. Marth, 9.273 T and V. Niederberger. 2011. Recombinant allergens: what does the future hold? J. Allergy Clin. Immunol. 127:860-864. sum 30.168
c) Invited Articles & Reviews without IF: n = 1
Nr. Article 1. Gadermaier, E. In shape-the art of mapping conformational epitopes. 2011. Int Arch Allergy Immunol DOI:10.1159/000332948 d) Book contributions: n = 0 e) Abstracts, printed in periodicals: n = 0 f) Abstracts, in congress proceedings or abstract books: n = 30
1. Flicker, S. To study allergen structure with monoclonal antibodies. Annual Meeting of the European Acadamy of Allergology and Clinical Immunology, Istanbul, Turkey, June 2011. 2. Gadermaier, E., C. Lupinek, P. Steinberger, R. Valenta, S. Flicker. Determination of allergen-specificity by heavy chains in grass pollen allergen-specific IgE antibodies. Annual Meeting of the Austrian Society for Allergology and Immunology, Graz, Austria, September 2011. 3. R. Campana, S. Vrtala, B. Maderegger, Y. Dall’Antonia, D. Zafred, K. Blatt, H. Herrmann, M. Focke-Tejkl, I. Swoboda, S. Scheiblhofer, A. Gieras, A. Neubauer, W. Keller, P. Valenta, J. Thalhamer, S. Spitzauer, R. Valenta. Altered IgE epitope presentation: molecular and immunological characterization of a recombinant hypoallergenic trimer of the major birch pollen allergen Bet v 1, EAACI-GA2LEN 9th Immunology Winter School, Davos, Switzerland, February 3 - 6, 2011.
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4. S. Pahr, C. Constantin, N. Papadopoulus, M. Mäkelä, C. Ebner, A. Mari, I. Mittermann, S. Vrtala, R. Valenta. Characterization of a new wheat food allergen, EAACI Food Allergy and Anaphylaxis Meeting - FAAM 2011, Venice, February 17- 19, 2011 5. A. Schmidhuber, S. Pahr, C. Constantin, N. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, R. Valenta. Isolation, characterization and expression in Escherichia coli of a cDNA coding for a novel major wheat food allergen, First EAACI Food Allergy and Anaphylaxis Meeting, - FAAM 2011, Venice, February 17 - 19, 2011. 6. R. Campana, S. Vrtala, B. Maderegger, P. Jertschin, G. Stegfellner, I. Swoboda, M. Focke-Tejkl, K. Blatt, A. Gieras, D. Zafred, A. Neubauer, P. Valenta, W. Keller, S. Spitzauer, R. Valenta. Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly 30th European Academy of Allergy and Clinical Immunology (EAACI), Istanbul, Turkey, June 06 -15, 2011 7. A. Schmidhuber, S. Pahr, C. Constantin, N. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, R. Valenta Isolation and characterization of the major wheat food allergen Low molecular weight glutenin GluB3-237th PhD symposium, Vienna, June 15 - 16, 2011 8. S. Pahr, C. Constantin, N. Papadopoulus, M. Mäkelä, C. Ebner, A. Mari, I. Mittermann, S. Vrtala, R. Valenta. Characterization of alpha purothionin as a new wheat food allergen, 7th PhD symposium, Vienna, June 15 - 16, 2011 9. Y. Resch, M. Weghofer, S. Seiberler, F. Horak, S. Scheiblhofer, B. Linhart, WR. Thomas, J. Thalhamer, R. Valenta, S. Vrtala. The mite tropomyosin Der p 10 is a diagnostic marker for broad sensitizations to house dust mite allergens, 7th YSA-PhD Symposium, Vienna, June 15 - 16, 2011 10. Y. Resch, M. Weghofer, A. Mari, S. Scheiblhofer, M. Focke, J. Thalhamer, R. Valenta, S. Vrtala. The effect of in vitro-gastro-duodenal digestion of the major shrimp allergen tropomyosin on IgE reactivity and allergenic activity, Annual meeting of the ÖGAI, Vienna, September 15 - 17, 2011 11. S. Banerjee, Y. Resch, K. W. Chen, I. Swoboda, M. Focke Tejkl, S. Scheiblhofer, M. Kronqvist, M. van Hage, A. Mari, A. Purohit, G. Pauli, E. N Sibanda, W. Thomas, A. Adegnika, J. Thalhamer, R. Valenta, S. Vrtala. Striking differences in the molecular IgE recognition profiles revealed with recombinant house dust mite allergens Der p 11 and Der p 14 in different populations. Annual meeting of the ÖGAI, Vienna, September 15 - 17, 2011 12. KW. Chen, K. Blatt, W.R. Thomas, I. Swoboda, P. Valent, R. Valenta, S. Vrtala. Hypoallergenic combination vaccines consisting of reassembled Der p 1 and Der p 2 fragments for immunotherapy of house dust mite allergyAnnual meeting of the ÖGAI, Vienna, September 15 - 17, 2011 13. S. Pahr, C. Constantin, N. Papadopoulus, S. Giavi, M. Mäkelä, C. Ebner, A. Mari, I. Mittermann, S. Vrtala, R. Valenta. Characterization of a novel allergen involved in wheat food allergy. ÖGAI Jahrestagung 2011, Graz, September 15 - 17, 2011 14. A. Schmidhuber, S. Pahr, C. Constantin, S. Giavi, N. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, R. Valenta. Tri a 36: a novel major wheat food allergen. Annual Meeting of the Austrian Society of Allergology and Immunology, Graz, September 15 - 17, 2011 15. S. Pahr, C. Constantin, N. Papadopoulus, S. Giavi, M. Mäkelä, C. Ebner, A. Mari, I. Mittermann, S. Vrtala, R. Valenta. Characterization of a novel allergen involved in wheat food allergy. Zentrumsretreat, Vienna, September 27, 2011 16. C. Kitzmueller, C., B. Nagl, S. Deifl, C. Walterskirchen, B. Jahn-Schmid, G. Zlabinger, B. Bohle. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Tukey. Human basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1, June 11-15, 2011,
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17. Jahn-Schmid, B, M. Hauser, N. Wopfner, R. Asero, C. Ebner, F. Ferreira and B. Bohle. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Tukey. Antigenicity versus cross-reactivity: Amb a 1, the major ragweed pollen allergen, and its mugwort homologue Art v 6, June 11-15,2011. 18. B. Subbarayal, C. Möbs, NW. de Jong, C. Ebner, N. Reider, RG. van Wijk, W. Pfützner, B. Bohle. Effects of immunotherapy with birch pollen on food-allergen specific antibodies. EAACI Immunology Winterschool, Davos, February 3-6, 2011 19. B. Subbarayal, C. Möbs, NW de Jong, C. Ebner, N. Reider, RG. van Wijk, W. Pfützner, B. Bohle. Effects of immunotherapy with birch pollen on food-allergen specific antibodies. 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011. 20. S. Deifl, C. Kitzmüller; G. Zlabinger, P. Steinberger, B. Bohle Are all Toll-like receptor (TLR) ligands potential adjuvants in allergy vaccines? EAACI Immunology Winterschool, Davos, February 3-6, 2011 21. S. Deifl, C. Kitzmüller, G. Zlabinger, P. Steinberger, B. Bohle. Are all Toll-like receptor (TLR) ligands potential adjuvants in allergy vaccines? 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011. 22. S. Deifl, C. Kitzmüller; G. Zlabinger, P. Steinberger, B. Bohle. Searching of TLR ligands with adjuvant activity in allergy vaccines. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Graz, Austria, September 15-17, 2011 23. S. Deifl , C. Kitzmüller; G. Zlabinger, P. Steinberger, B. Bohle. Searching for TLR ligands with adjuvant activity in allergy vaccines. CePPII retreat, Vienna, September 27, 2011 24. C. Kitzmueller, M. Wallner, S. Deifl, S. Mutschlechner, G. Zlabinger, F. Ferreira, B. Bohle. Allergen fold affects antigen processing and presentation. EAACI Immunology Winterschool, Davos, February 3-6, 2011 25. C. Kitzmüller, Nagl B., Deifl S., Walterskirchen C., Jahn-Schmid B., Zlabinger G., Bohle B. Human basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Graz, September 15-17, 2011 26. C. Kitzmüller, Nagl B., Deifl S., Walterskirchen C., Jahn-Schmid B., Zlabinger G., Bohle B. Human basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. CePPII retreat, Vienna, September 27, 2011 27. D. Kollmann, C. Ebner, A. Mangold, H.J. Ankersmit, B. Bohle. The role of alpha-Gal in Type I allergy to meat. 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011. 28. N. Zulehner, B. Nagl, V. Leb-Reichl, C. Walterskirchen, G. Zlabinger, W.F. Pickl, B. Bohle. Human allergen-specific T cell clones show high heterogeneity and plasticity within the Th2 lineage. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Graz, September 15-17, 2011 29. N. Zulehner, B. Nagl, V. Leb-Reichl, C. Walterskirchen, G. Zlabinger, W.F. Pickl, B. Bohle.Human allergen-specific T cell clones show high heterogeneity and plasticity within the Th2 lineage. CePPII retreat, Vienna, September 27, 2011 30. M. Schuschnig, Kitzmüller, C., Bohle, B. Expression of pattern recobnition receptors by oral epithelial cell lines, Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Graz, September 15-17, 2011 g) Teaching Scripts and Books: n = 0 h) Articles in Medical Journals: n = 0
58 Performance Report 2011 Immunopathology i) Public activity n = 12
1. Rudolf Valenta: SIT bei Kindern und Jugendlichen, Ärzte Woche Nr.4, S. 21-22, 2011 2. Rudolf Valenta: Allergen-spezifische Immuntherapie bei Kindern und Jugendlichen, www.springermedizin.at/schwerpunkt/allergologie 3. Rudolf Valenta: Allergie Spezial- 100Jahre spezifische Immuntherapie-Jahrestagung der ÖGAI, Ärzte Woche Nr.4, S. 20, 2011 4. Rudolf Valenta: Allergie Spezial- 100Jahre spezifische Immuntherapie-Jahrestagung der ÖGAI, www.springermedizin.at/ 5. Rudolf Valenta: Neue Option für Heuschnupfen-Opfer, Ärzte Woche, Ärzte Woche Nr.4, S. 23, 2011 6. Rudolf Valenta: Neue Option für Heuschnupfen-Opfer, www.springermedizin.at/schwerpunkt/allergologie 7. Rudolf Valenta: Allergie-Impfstoff wird an Patienten geprüft, APA - www.zukunftswissen.apa.at, S.1-2, 2011 8. Rudolf Valenta: Wespen - was tun gegen den allergischen Schock?, Profil 31, S. 69-72 9. Bohle Barbara: „Der Würdigungspreis 2011 des Landes Vorarlberg für Biotechnologin Bohle“, [email protected] 10. Bohle Barbara: „Der Krieg im Körper“, Wann&Wo 11. Bohle Barbara: „In den Schlagzeilen, Barbara Bohle, Weekend, Das Beste am Wochenende 12. Bohle Barbara: „Proteingruppe als Allergie-Multiplikator“, Interessensgemeinschaft Allergenvermeidung
1.3.2. Research Awards: n = 15
1. Katarzyna Niespodziana: Clemens von Pirquet Award 2011 of the Austrian Society for Allergology and Immunology 2. Katarzyna Niespodziana: Award of Excellence 2011 of the Austrian Federal Minister for Science and Research 3. Katarzyna Niespodziana: Dr. Maria Schaumayer Foundation Award 2011 4. Sandra Pahr: Posteraward at the ÖGAI Jahrestagung 2011, Graz, September 15 – 17, 2011 5. Sandra Pahr: Posteraward at the 2. Zentrumsretreat, Vienna, September 27, 2011 6. Irene Mittermann: Forschungspreis ”Atopische Dermatitis” der Stiftung Pro Derma, Hamburg, 2011 7. Rudolf Valenta: Forschungspreis ”Atopische Dermatitis” der Stiftung Pro Derma, Hamburg, 2011 8. Kitzmüller Claudia: Oral Session Price at the 30th Congress of the European Academy of Allergy and Clinical Immunology (EAACI) in Istanbul, Turkey, June 11- 15, 2011 9. Kitzmüller Claudia: Travel Grant from the Austrian Research Association to attend the 30th Congress of the EAACI in Istanbul, Turkey, June 11-15, 2011 10. Kitzmüller Claudia: ÖGAI Poster Award at the Annual Meeting of the Austrian Society for Allergology and Immunology in Graz, Austria, September 15-17, 2011 11. Kitzmüller Claudia: Poster Award at CePPII retreat, Vienna, September 27, 2011
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12. Subbarayal Brinda: Exchange Research Fellowship Award of the European Academy of Allergy and Clinical Immunology (EAACI), 2011 13. Subbarayal Brinda: Poster Prize at the 30th Congress of the European Academy of Allergy and Clinical Immunology (EAACI) in Istanbul, Turkey. 2011 14. Kollmann Dagmar: Zuspruch eines MDPhD Exzellenzprogrammes der Med Uni Wien 15. Bohle Barbara: Award for scientific achievements from the country Vorarlberg, Austria
1.3.3. Invited lectures: n = 42
1. Rudolf Valenta: MeDALL kick-off meeting, Centre for Research in Environmental Epidemology (CREAL): “In vitro diagnosis in the definition of the IgE phenotype” and “Characterization of inhalant and food allergens”, January 24-26, 2011, Barcelona, Spain 2. Rudolf Valenta: Wiener Allergiekurs 2011, österreichishe Ärztekammer: “Innovationen”, January 28–29, 2011, Vienna, Austria 3. Rudolf Valenta: Symposium 2011, ICA PhD Program: “Therapeutic strategies for allergy”, February 1, 2011, Salzburg, Austria 4. Rudolf Valenta: The EAACI SummIT 2011, 100 Years of Immunotherapy in Allergy. From noon till dawn…: “Are the new modalities of SIT realistic?”, February 24, 2011, Geneva, Switzerland 5. Rudolf Valenta: ESF-JSPS Frontier Conference for Young Researchers, European Science Foundation (ESF) and the Japan Society for the Promotion of Science (JSPS), Cutting Edge Immunology and its Clinical Application: “Regulation of allergen responses”, March 4-5, 2011, Hulshorst, Netherlands 6. Rudolf Valenta: IFCC-Worldlab EuroMedLab Berlin 2011, 21st International congress of Clinical Chemistry and Laboratory Medicine: “Component-based diagnostics – recombinant allergens as novel diagnostic tools”, May 15-19, 2011, Berlin, Germany 7. Rudolf Valenta: EAACI Congress 2011, European Academy of Allergy and Clinical Immunology, Workshop: “Allergenic molecules: natural or recombinant?, Recombinant forms are better for….”: ”Meet the expert – Rudolf Valenta. Recombinant allergens in allergy diagnosis and treatment”, June11-15, 2011, Istanbul, Turkey 8. Rudolf Valenta: Seminar an der University of Pittsburg, IUIS Council Meeting in Washington: “New forms of diagnosis and therapy for allergy”, June 20-24, Pittsburg and Washington, USA 9. Rudolf Valenta: FAST EU-project meeting, August 22-23, 2011, Madrid, Spain 10. Rudolf Valenta: Deutsche Allergiekongress, Klinisch-Wissenschaftliches Symposium, Inhalationsallergien, In-Vitro Allergie-Diagnostik auf molekularer Ebene: „Inhalationsallergien“, September 8-9, 2011, Wiesbaden, Germany 11. Rudolf Valenta: 55. österreichischer HNO ongreß: „100 Jahre Immunotherapie: eine Erfolgsgeschichte“, September 14-17, 2011, Vienna, Austria 12. Rudolf Valenta: Jahrestagung der österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI): „Zukunft der Immuntherapie – individualisierte Therapie / rekombinante Allergene“, September 15-17, 2011, Graz, Austria 13. Rudolf Valenta: Symposium: „Opportunities for control over asthma today, freedom from asthma tomorrow“, September 29, 2011, Guy´s Hospital, London, United Kingdom 14. Rudolf Valenta: Projekt meeting “Mead Johnson Nutritionals”, October 5-6, 2011, MJN European Headquarters, Amsterdam, Netherlands
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15. Rudolf Valenta: Annual Meeting of the Croatian Immunological Society: “From immune recognition of allergens to new forms of diagnosis and therapy”, October 6-7, 2011, Rabac, Croatia 16. Rudolf Valenta: Projekt meeting “Phadia”, October 10-11, 2011, Uppsala, Sweden 17. Rudolf Valenta: 40th Annual Congress of the Hungarian Society for Immunology (HSI): “Towards side-effect free allergy vaccines”, October 12-13, 2011, Kecskemet, Hungary 18. Rudolf Valenta: 2nd EFIS-EJI African International Conference on Immunity (AICI): “Immunity in infectious diseases and allergy – diagnosis, treatment and prevention”, November 3-7, 2011, Victoria Falls, Zimbabwe 19. Rudolf Valenta: Annual Meeting of SEAIC 2011, Symposium International de Alergia Alimentaria: “Towards side effect-free allergen specific immunotherapy”, November 10, 2011, Barcelona, Spain 20. Rudolf Valenta: Journal of Internal Medicine (JIM) Symposium: “New approaches to immune modulation in allergic disease”, November 11-12, 2011, Stockholm, Schweden 21. Rudolf Valenta: Komponentenworkshop, Phadia: “Pathomechanismen der Allergie”, November 18, 2011, Vienna, Austria 22. Rudolf Valenta: XXXVIII Congresso Brasileiro de Alergia e Imunopatologia 2011: “Towards side effect-free allergen-specific immunotherapy” and “IgE immunoapheresis for allergy treatment”, November 21-23, 2011, Fortaleza, Brazil 23. Rudolf Valenta: 2nd EFIS-EJI Intensive Educational Course in Clinical Immunology, Advanced Course in Innovative immunologically-based therapies: “Allergy”, November 28- 29, 2011, Paris, France 24. Rudolf Valenta: 22nd World Allergy Congress: “Newest forms of SIT”, December 4-8, 2011, Cancun, Mexico 25. Sabine Flicker: Research Seminar: “Recombinant human antibodies for diagnosis, treatment and prevention of allergy”. Charite, Berlin, Germany, May 30, 2011 26. Susanne Vrtala: “Golnik Symposium 2011” from October 6-8, 2011 in Bled, Slovenia.Title: Recombinant mite allergens for diagnosis and immunotherapy 27. Susanne Vrtala: “Annual Meeting of the French Society for Immunology SFI 2011” from November 8-10, 2011 in Montpellier, FranceTitle: Recombinant mite allergens for diagnosis and immunotherapy 28. Susanne Vrtala: „XXII World Allergy Congress“ from December 4-8, 2011 in Cancún, Mexico.Title: Recombinant allergens for diagnosis 29. Irene Mittermann: “EAACI”, from June 11-14, 2011 in Istanbul, Turkey, Title: Component resolved diagnosis in venom allergy 30. Irene Mittermann: “XXII World Allergy Congress“ from December 4-8, 2011 in Cancún, Mexico.Title: Improving diagnosis of venom allergy with recombinant allergens 31. Beatrice Jahn-Schmid: Dept. of Clinical immunology, Medical University of Wroclaw, Poland, April 2011, Modified allergens and allergen-specific immunotherapy, 32. Margit Focke-Tejkl: Vortrag Pirquet Club. December 12, 2011.“Peptid-Viruscarrier- Immuntherapie gegen Gräserpollenallergie: Theorie, 33. Birgit Linhart: Vortrag Pirquet Club 4.4.2011 “Rekombinante hypoallergene Allergenderivate zur Behandlung von Gräserpollenallergien”, Vortrag Pirquet Club, April 4, 2011, 34. Bohle Barbara: Apples are a peach but can drive birch pollen-allergic patients nuts. PhD Symposium, Salzburg, Austria. February 1, 2011.
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35. Bohle Barbara: Sekundäre Nahrungsmittelallergie – Relevanz der Kreuzreaktionen. Wiener Pirquet Club Spezial, May 7, 2011 36. Bohle Barbara: Allergen-specific T regulatory cells. 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011. 37. Bohle Barbara: Local and systemic regulation of the allergic immune response. 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011. 38. Bohle Barbara: Is the T cell still director in the immunological orchestra? 30th EAACI Congress, Istanbul, Turkey, June 11-15, 2011. 39. Bohle Barbara: Relegation of new players in the antigen-presenting field: Human basophils do not serve as antigen-presenting cells for the major birch pollen allergen Bet v 1. 6. Deutscher Allergie Kongress, Wiesbaden, Germany. September 8, 2011 40. Bohle Barbara: Toll-like receptors (TLR) ligands as adjuvants, 13th Paul Ehrlich Seminar on Allergen Products for Diagnosis and Therapy: Regulation and Science, Washington DC, September 14-17, 2011 41. Bohle Barbara: Dissecting allergen-specific CD4+ T cell responses. Annual meeting of the Catalan Society for Immunology, Barcelona, Spain, November 17.-18, 2011 42. Bohle Barbara: Allergen-spezifische Immuntherapie. Im Rahmen der Tagung „10 Jahre Pädiatrische Allergologie und Pneumologie: Klinische Forschung from Bench to Bedside“, Frankfurt, Germany, November 26, 2011
1.3.4. Congress organization
Division National congress Intern. Congress, member Name, date Function Name, date Function Name: Rudolf Valenta “Wiener Allergiekurs”, Co- 01/28/2011-01/29/2011, organizer Vienna Rudolf Valenta 2nd EFIS-EJI African Co-organizer International Conference on Immunity, 11/03/2011- 11/017/2011, Victoria Falls, Zimbabwe Rudolf Valenta „100 Jahre Co- Antrittsvorlesung Clemens organizer v. Pirquet“, 11/16/2011, Vienna Rudolf Valenta “Molekulare Allergologie”, Co- Phadia, 11/18/2011- organizer 11/19/2011, Vienna Rudolf Valenta SFB-Meeting, Organizer Ottenstein, 10/24/2011- 11/25/2011 Barbara Bohle EAACI Immunology Organizing Winter School, committee Davos, 02/03- 02/06/ 2011
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1.3.5. Hosting speakers
division member Speaker´s name Affiliation Date Rudolf Valenta Dr. Maria A. Singarpore Immunology Network 03/11/2011 Curotto De Lafaille Singapore Rudolf Valenta Prof. Paul J. The Rayne Institute St. 03/18/2011 Ciclitira Thomas`Hospital, London UK Rudolf Valenta Dr. Hans Grönlund Dept. of Medicine, Unit of Clinical 04/15/2011 Immunology and Allergy, Karolinska Institutet, Sweden Rudolf Valenta Prof. Marcus Dept. of Dermatology and Allergology 05/11/2011 Maurer Charité – Universitätsmedizin Berlin, Germany Rudolf Valenta Prof. Fred Cincinnati Children´s Hospital 05/23/2011 Finkelman Medical Center&the Cincinnati Veterans Affairs Medical Center, Cicinnati, Ohio. Rudolf Valenta Prof. Jörg Lehmann Dept. of Cell Technology, 05/27/2011 Frauenhofer Inst. For Cell Therapy and Immunology Rudolf Valenta Dr. Fred Finkelman Cincinnati Children´s Hospital 10/24/2011- Medical Center&the Cincinnati 10/25/2011 Veterans Affairs Medical Center, Cicinnati, Ohio Rudolf Valenta Dr. Simon Hogan Cincinnati Children´s Hospital, 10/24/2011- Cincinnati, OH 45229, USA 10/25/2011
Rudolf Valenta Dr. Marsha Wills- Division of Immunobiology, Cincinnati 10/24/2011- Karp Children’s Hospital Medical Center, 10/25/2011 Cincinnati, OH 45229 Rudolf Valenta Dr. Chris Karp Cincinnati Children’s Hospital 10/24/2011- Medical Center, Cincinnati, OH 10/25/2011 45229 Rudolf Valenta Dr. Francine Respiratory and Environmental 12/01/2011 Kauffmann Epidemiology, CESP-Centre for Research in Epidemiology and PopulationHealth, Inserm, Villejuif, France Rudolf Valenta Prof. Gabrielle Hôpitaux universitaires de 12/20/2011 Pauli Strasbourg, France Rudolf Valenta Prof. Lars K. Allergy Clinic, Copenhagen Hospital 12/21/2011 Poulsen at Gentofte Rudolf Valenta Dr. Hans-Jørgen Allergy Clinic, Copenhagen Hospital 12/21/2011 Malling at Gentofte
1.3.6. Mobility
Name Program University, Land Time frame Division In Out Silwia Wroclaw Medical Wroclaw Medical 06/20/11 – 3 X Smolinska University grant University 09/20/11 Poland Cabauatan Wissenschaftl. MA Philippinen 04/16/10 – 3 X 63 Performance Report 2011 Immunopathology
Clarissa ohne DV 02/19/11 Breyer Isabella MUW-Medizinstudent Österreich 09/7/09 – 3 X (Praktikant) 01/31/11 Maria Jesus IFMSA International Universitat de Lleida 07/30/11 – 3 X Puy Parache Federation of Medical Spain 08/27/11 Students Association Natalia Lucas IFMSA International Spain 07/4/11 – 3 X Collado Federation of Medical 07/29/11 Students Association Pretzer Carina Praktikant UNI Wien 08/1/11 – 3 X 08/31/11 Appel Mareike Student UNI Wien 05/31/11 – 3 X 12/31/11 Altrichter Charité Charié Berlin 10/17/11 – 3 X Sabine wissenschaftl. MA Dermatologie 10/27/11 ohne DV Muglia Cecill Gastforscher Falcutad de Ciencia 12/28/10 – 3 X (BB) Exactas, UNLP, 03/24/11 Argentinien Debeljak Praktikant MUW MUW 05/17/11 – 3 X Franka 0600437 07/08/11 (BB) Gutfreund Praktikant 04/04/11 – 3 X Sandra ongoing Narayanan PhD student India 11/11/11 – 3 X Meena ongoing Balakumari Brinda EAACI Exchange Paul Ehrlich Institut, 05/02/11 – 3 X Subbarayal research fellowship BRD 10/28/11 Bharani Doktoratskolleg MUW UNI Wien 08/15/2011 – 3 X Srinivasan 02/20/2012
1.3.7. Activities in Advisory Boards
Name Society/Institute/Journal Function Rudolf Valenta Iranian Journal of Allergy, International Board Consultant Asthma and Immunology” Barbara Bohle Wissenschaftlicher Beirat des Scientific advisor Paul Ehrlich Instituts, Langen, BRD
1.3.8. Editorial Activities
Name Journal Function Rudolf Valenta International Archives of Allergy Editor in Chief and Immunology Rudolf Valenta International Archives of Allergy Editorial Board and Immunology Rudolf Valenta ACI International Editorial Board
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Rudolf Valenta Allergo Journal Editorial Board Rudolf Valenta Journal of Investigational Editorial Board Allergology & Clinical Immunology Rudolf Valenta European Journal of Clinical Editorial Board Investigation Rudolf Valenta Calcium Binding Proteins Editorial Board Rudolf Valenta International Journal of Editorial Board Immunorehabilitation Rudolf Valenta American Journal of Plant Editorial Board Sciences Rudolf Valenta Revista Alergia Mexico Editorial Board Barbara Bohle International Archives of Allergy Managing Editor and Immunology Barbara Bohle Clinical and Experimental Editorial Board Member Allergy Barbara Bohle Immunotherapy Editorial Board Member
1.3.9. Review Activities
Name Grants/Thesis/Habilitation Rudolf Valenta Habilitation,02/ 2011 Barbara Bohle Research Grant Proposal of the Medical Research Council, UK Barbara Bohle PhD Thesis of Michael Lichtenauer “Secretome of apoptotic cells causes cardioprotection and inhibits ventricular remodelling after acute myocardial infarction” Barbara Bohle PhD Thesis committee of Christine Bannert (03/29/2011) Barbara Bohle PhD Thesis committee of Jiang Zhou (11/16/2011)
1.3.10. Filed and granted patents
Name Patent Susanne Vrtala Patent P9501PC00: Wheat antigens and peptides for diagnosis of wheat induced hypersensitivity
Rudolf Valenta Microparticles comprising carbohydrate beads covalently linked with allergen for use in immunotherapy and diagnostics", in Canada, CA 2482973 (11/22/2011) Rudolf Valenta Process for the preparation of hypoallergenic mosaic antigens", Japan, JP 4756864 (June 10, 2011) 3. "Hypoallergenic polypeptides based on fish parvalbumin Rudolf Valenta Allergen from house dust mites (Der p 21)" in Japan, JP 4713933 (04/01/2011) Rudolf Valenta Protein allergen derivatives (Head to Tail" in Australien, AU 2005312324 (08/25/2011) Rudolf Valenta Nutritional formulation comprising a cow’s milk peptide-containing hydrolysate and/ or peptides derived thereof for tolerance induction, US Patent Application No: 2011/0195,153
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Rudolf Valenta Method for identifying allergenic proteins and peptides, US Patent Application No: 2010/0143,262 Rudolf Valenta US Patent No. RE42324 (our ref: P6659US01) COMPUND FOR TREATMENT OF ALLERGY AND ASTHMA, grant date: 05/03/2011. Rudolf Valenta Japanese Patent No. 4881526 (our ref: P6685JP00) NON-ANAPHYLACTIC FORMS OF GRASS POLLEN Phl p 6 ALLERGEN AND THEIR USE, grant date 12/09/2011 Rudolf Valenta Canadian Patent No. 2441048 (our ref: P6659CA00) NOVEL COMPOUND FOR TREATMENT OF ALLERGY AND ASTHMA, grant date12/13/2011
1.3.11. Grants
Funding agency Title of project Principal investigator FWF-SFB Coordination project Rudolf Valenta FWF-SFB Molecular approaches to dissect Rudolf Valenta pathomechanisms of allergy. Biomay Impfstoffe und Toleranzstrategien für Typ I Rudolf Valenta Alllergie. Phadia Utility of recombinant allergens, wheat and venom Rudolf Valenta allergens. Christian Doppler Therapeutic peptide vaccines for allergic asthma. Rudolf Valenta Forschungsgesellschaft EU-Kommission/FP7 EU Projekt MedAll Rudolf Valenta „Health“ EU-Kommission/FP7 EU Projekt Predicta Rudolf Valenta „Health“ Karger Verlag Personalkosten, Sachkosten Rudolf Valenta FWF Doktoratskolleg Rudolf Valenta FWF Doktoratskolleg Barbara Bohle FWF-SFB The role of cell-mediated immunity in type I food Barbara Bohle allergies. Christian Doppler Immunmodulation allergischer Erkrankungen Barbara Bohle Gesellschaft und Biomay FWF Strukturelle Merkmale und Immunogenität von Barbara Bohle Allergieimpfstoffen FWF-SFB Molecular, immunological and structural Susanne Vrtala characterization of mite allergens for diagnosis, prevention and specific immunotherapy. Christian Doppler Development of allergen chips. Susanne Vrtala Forschungsgesellschaft FWF MHC clas II tetramers in allergy research. Beatrice Jahn-Schmid Österreichische Einfluss der Hyposensibilisierung auf Beatrice Jahn-Schmid National Bank allergenspezifische Immunantwort bei Pollenallergikern. European Research Seventh Towards safe and effective Ines Swoboda Grant Framework immunotherapy of persistent lifethreatening food allergies. Bundesministerium für Towards safe and effective Immunotherapy . of Ines Swoboda Wissenschaft und persistent life- threatening food allergies. Forschung, Eu- Zusatzfinanzierung FWF Regulatory role of allergen-specific antibodies Sabine Flicker FWF Recognition of allergen epitopes in secondary IgE Birgit Linhart response.
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1.3.12. Career Developments a) Habilitations: n= 0 b) Habilitations in progress: n = 2
1. Mittermann Irene: Molekulare Allergologie, "Molecular characterisation of allergens for diagnosis and therapy". (2010 – ongoing) 2. Linhart Birgit: Molekulare Allergologie (2010 – ongoing) c) Professorships: n= 0
1.3.13. Teaching a) Bachelor students: n = 1
1. Gutfreund Sandra: Bachelor student, (2011 – in progress), Investigation of the function of Hfq protein by mutational analysis in E.Coli b) Diploma and MDiploma students: n = 9
1. Appel Mareike: Diploma student (6/2011 – in progress), Entwicklung und Charakterisierung eines IgE-spezifischen Immunotoxins 2. Breyer Isabella: Diploma student, Entwicklung und präklinische Evaluierung neuer Vakzine gegen Allergien, (09/07/2009 – in progress) 3. Hameter Verena: Diploma student, Expression, purification, structural and immunological characterization of a Phl p5 mosaic protein (2011 – in progress) 4. Kalser Julia: Diploma Thesis: Untersuchung der Immunantwort auf Allergen- Modulator-Fusionsproteine (2010-in progress). 5. Kollmann Dagmar: Diploma Thesis: Identification of cross-reactive allergens in buckwheat, poppy and hazelnut (10/2008-05/2011) 6. Mayrhofer Hannes: Diploma student: Erstellung und Charakterisierung von rekombinanten Hybridmolekülen für die Therapie der Gräserpollenallergie, 10/27/2008 – in progress. 7. Schuschnig Marina: Diploma Thesis: Reinigung und Charaktrisierung der Glutathion- S-Transferase aus Birkenpollen (2010-in progress) 8. Walterskirchen Christian: Diploma Thesis: Humoral and cellular characterization of minor allergens in birch pollen. (02/01/2010-in progress). 9. Zwicker Christian: Diploma Thesis: Biochemical and immunological characterization of recombinant Glutathione-S-transferase from birch pollen (10/2011- in progress) c) PhD, MDSci, MD students: n = 21
1. Banerjee Srinita: PhD student: Production and evaluation of peptide vaccines for house dust mite immunotherapy (2009-in progress) 2. Chen Kuan-Wei: PhD student: Synthesis and characterization of house-dust mite allergen derivatives for immunotherapy, (2006-2011)
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3. Cabauatan Clarissa: PhD student: Pollen Aerobiology and Pollen-Specific Immunoglobulin-E Levels of Selected Allergic Patients in the Philippines (2011 – in progress). 4. Deifl Stephan: Doctoral Thesis: Development of allergy vaccines using Toll-like receptor ligands as immunomodulatory component. (5/2009-in progress) 5. Gadermaier Elisabeth: PhD Thesis: Allergen-specific antibodies (2006-in progress) 6. Gallerano Daniela: PhD student, Towards the definition of HIV-related anitbody- signatures and new immunogens for vaccine design, (2009 – in progress). 7. Geller Beate: PhD Thesis in Molecular Biology: Molecular characterization and epitope mapping of egg allergens (2009 – 6/2011), University of Vienna 8. Geroldinger-Simic Marija Dr.: Doctoral Thesis: Epidemiological, clinical and immunological aspects of birch pollen-related food allergies (03/2008-in progress). 9. Gieras Anna: PhD thesis: Mechanisms of allergic inflammation. (2005 - 2011). 10. Kollmann Dagmar: PhD Thesis: The role of alpha-Gal in allergic reactions to meat (08/2011 – in progress) 11. Madritsch Christoph: PhD Thesis: Isolation of grass pollen specific IgE variable regions to study mechanisms of effector cell degranulation (2009- in progress) 12. Narayanan Meena Balakumari: PhD thesis: Mechanisms underlying secondary antibody responses (12/16/2009 – in progress). 13. Niespodzyana Katarzyna: PhD thesis: Development of viral carrier-based allergy vaccines (2007 - 2011) 14. Pahr Sandra: PhD student: Characterization of wheat food allergens (2010-in progress), 15. Resch Yvonne: PhD student: Chracterization of mite allergens (2010-in progress) 16. Schmidhuber Alexandra: PhD student:: Characterization of wheat allergens, (2009-in progress) 17. Schulten Veroniqué: Doctoral Thesis, Immunological features of in vitro and in vivo digested food allergens. (07/2007- 3/2011) 18. Srinivasan Barani: PhD thesis: Characterization of wheat allergens in celiac disease patients (2008 – in progress). 19. Subarrayal Brinda: Doctoral Thesis, Characterisation of allergen specific IgG4 antibodies. (10/2008-in progress) 20. Twaroch Teresa: PhD Thesis in Nutritional Science: Molecular characterization of inhalative allergens causing severe manifestations of allergy and development of tools for allergy diagnosis and treatment (2006 – 2011), University of Vienna 21. Zulehner Nora: PhD Thesis: Characterization of different phenotypes of allergen- specific Th2 cells (03/2011 – in progress)
2.3.14. Exams a) Oral examinations: n = 2
1. Susanne Vrtala: Oral commissional Exam 01/26/11: 1 2. Susanne Vrtala: Oral commissional Exam 04/01/11: 1 b) Diploma and Thesis-Examinations: n = 13
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1. Sabine Flicker: Nina Steinke, Diploma-Examination 2. Susanne Vrtala: Kuan Wei Chen, Thesis-Examination 11/14/11 3. Barbara Bohle: diploma examination of Stefanie Nickl, 6/28/11, “Increased levels of serum heat shock protein 27 as a possible marker for incipient obstructive pulmonary disease in a risk cohort” 4. Barbara Bohle: thesis defensio of Véronique Schulten, 22/3/11, “Immunological features of in vitro and in vivo digested food allergens” 5. Barbara Bohle: diploma examination of Dagmar Kollmann, 5/9/11, “Identification of cross-reactive allergens in buckwheat, poppy and hazelnut” 6. Barbara Bohle: PhD thesis examination, University of Salzburg of Elisabeth Maier, 10/11/11, “STAT6 controls the expression of the IL-4-regulated genes TCR-1 and IL-31 in naïve CD4+ T cells undergoing Th2 development” 7. Barbara Bohle: diploma examination of Matthias Zimmermann, 10/21/11 “Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70” 8. Barbara Bohle: diploma examination of Martina Schuschnig, 11/28/11, “Expression of pattern recognition receptors by oral epithelial cell lines” 9. Barbara Bohle: diploma examination of Peter Christopher Unterkreuter, 12/1/11 “Genotoxische Auswirkungen von Eisen Nanopartikel (FeCoB) auf humane Fibroblasten” 10. Rudolf Valenta: PhD thesis examination of Niespodzyana Katarzyna 11. Rudolf Valenta: PhD thesis examination of Twaroch Theresa. 12. Rudolf Valenta: PhD thesis examination of Kuan Wei-Chen 13. Rudolf Valenta: PhD thesis examination of Gieras Anna
c) Exam supervising: n= 0
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1.3.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2011 Valenta Rudolf 2.00 0.13 860.220 Basisvorlesung Immunologie Valenta Rudolf 6.00 0.20 802.000 BL 4 - Funktionssysteme und biologische Regulation Valenta Rudolf 2.00 2.00 902.276 TS Molekulare Allergologie Valenta Rudolf 10.00 2.50 648.022 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie Valenta Rudolf 4.00 4.00 648.027 Pathologie des Herz- und Kreislaufsystems - Ausgewählte Kapitel aus funktioneller Pathologie Valenta Rudolf 5.00 5.00 648.020 Hämathologie - Ausgewählte Kapitel ausFunktioneller Pathologie Valenta Rudolf 2.00 0.14 901.929 IAI-Basic Seminars Valenta Rudolf 2.00 0.25 902.241 IAI-Journal Club Bohle Barbara 2.00 0.13 860.220 Basisvorlesung Immunologie Bohle Barbara 1.00 1.00 809.061 MS: Methoden der Allergologie Bohle Barbara 2.00 2.00 648.035 Journal Club und Progress Report Bohle Barbara 2.00 2.00 648.036 Dissertantenseminar Ziele und Methoden der Allergologie Bohle Barbara 2.00 2.00 902.211 Dissertantenseminar: Ziele und Methoden der Allergologie Bohle Barbara 2.00 2.00 902.696 Journal Club and Progress Report Bohle Barbara 2.00 0.14 901.929 IAI-Basic Seminars Bohle Barbara 2.00 0.25 902.241 IAI-Journal Club Vrtala Susanne 2.00 0.50 860.037 Journal Club and Progress Report Vrtala Susanne 2.00 0.50 648.025 Journal Club und Progress Report Focke-Tejkl Margarete 2.00 0.50 648.025 Journal Club und Progress Report Focke-Tejkl Margarete 2.00 0.50 860.037 Journal Club and Progress Report Swoboda Ines 2.00 2.00 860.037 Journal Club and Progress Report Swoboda Ines 2.00 2.00 648.025 Journal Club und Progress Report Swoboda Ines 10.00 10.00 648.022 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie Flicker Sabine 2.00 0.50 860.037 Journal Club and Progress Report Lupinek Christian 4.00 0.50 808.004 SSM 3-Projektstudie (Wahlpflichtteil) Sum 40.61 WS 2011/12 Valenta Rudolf 2.00 0.17 502.282 Medical Propedeutics III - Linking Biology and Medicine Valenta Rudolf 4.00 4.00 514.002 Pathologie des Herz- und Kreislaufsystems - Ausgewählte Kapitel aus funktioneller Pathologie Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung Valenta Rudolf 5.00 2.00 514.034 gem. § 13 lit.a StG.)
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Valenta Rudolf 2.00 2.00 648.001 Journal Club and Progress Report Valenta Rudolf 4.00 1.00 648.002 Wissensschaftliches Arbeiten Valenta Rudolf 10.00 2.50 648.005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie Valenta Rudolf 5.80 0.40 803.002 BL 8 - Krankheit. Krankheitsursachen und Krankheitsbilder Valenta Rudolf 3.00 0.40 840.052 Medizinisches Propädeutikum Teil 1 Valenta Rudolf 2.00 0.18 860.008 Special Course: Scientific Presentation Valenta Rudolf 2.00 0.13 901.929 IAI-Basic Seminars Valenta Rudolf 2.00 2.00 901.931 Special Course: Advanced Molecular cloning techniques Valenta Rudolf 2.00 0.17 902.241 1IAI-Journal Club Valenta Rudolf 2.00 0.18 902.920 Special Course: Basic techniques in molecular and cellular biology Bohle Barbara 2.00 1.00 648.000 Journal Club und Progress Report Bohle Barbara 2.00 1.00 648.006 Dissertantenseminar Ziele und Methoder der Allergologie Bohle Barbara 2.00 0.18 860.008 Special Course: Scientific Presentation Bohle Barbara 2.00 0.13 901.929 IAI-Basic Seminars Bohle Barbara 2.00 2.00 901.933 Special Course: Cellular allergology Bohle Barbara 2.00 2.00 902.211 Dissertantenseminar: Ziele und Methoden der Allergologie Bohle Barbara 2.00 0.17 902.241 IAI-Journal Club Bohle Barbara 2.00 2.00 902.564 Journal Club und Progress Report Bohle Barbara 2.00 0.18 902.920 Special Course: Basic techniques in molecular and cellular biology Focke-Tejkl Margarete 2.00 0.50 860.023 Journal Club and Progress Report Vrtala Susanne 2.00 0.50 860.023 Journal Club and Progress Report Jahn-Schmid Beatrice 2.00 1.00 648.000 Journal Club und Progress Report Jahn-Schmid Beatrice 2.00 1.00 648.006 Dissertantenseminar Ziele und Methoden der Allergologie Jahn-Schmid Beatrice 1.00 1.00 902.542 Grundlagen der Allergologie Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung Swoboda Ines 5.00 1.00 514.034 gem. § 13 lit.a StG.) Swoboda Ines 4.00 1.00 648.002 Wissensschaftliches Arbeiten Swoboda Ines 10.00 2.50 648.005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie Flicker Sabine 2.00 0.50 860.023 Journal Club and Progress Report Flicker Sabine 2.00 0.50 860.006 B cells and antibodies Swoboda Ines 2.00 0.50 860.006 B cells and antibodies Sum 32.79 Total sum SS+WS 73.40
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1.4 Division for Medical Biotechnology Head: Heimo Breiteneder, Professor
1. Publications7 IF Number Top/Std/Subst Heimo Breiteneder 34,929 14,2 6xTop, 2xSt, 1xSSt Karin Hoffmann-S. 33,240 11,4 2xTop, 5xSt, 2xSSt Yan Ma 0,672 0,2 1xSt Christian Radauer 7,111 3 1xTop, 1xSt Stefan Wagner 7,327 3 1xTop, 1xSt Sum 64,646 26,4 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2
2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Heimo Breiteneder 1 3 Karin Hoffmann-S. 3 3 0 Yan Ma 4 1 Christian Radauer 1 Stefan Wagner 2 Sum 3 8 7
3. Teaching SS* WS* total W+S oral Exams Heimo Breiteneder 5,40 5,60 11,00 2 Karin Hoffmann-S. 3,90 5,23 9,13 4 Yan Ma 10,84 12,70 23,54 19 Christian Radauer 0,40 1,23 1,63 Stefan Wagner 1,40 0,00 1,40 Sum 21,94 24,76 46,7 25
7 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications.
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1.4.1. Publications a) Peer-reviewed original articles: n = 17
Nr. Article IF Class 1. Radauer, C., F. Adhami, I. Furtler, S. Wagner, D. 2,916 St. Allwardt, E. Scala, C. Ebner, C. Hafner, W. Hemmer, A. Mari, and H. Breiteneder. 2011. Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy. Mol Immunol (48): 600-609. 2. Bublin, M., S. Dennstedt, M. Buchegger, M. Antonietta 4,195 Top Ciardiello, M. L. Bernardi, L. Tuppo, C. Harwanegg, C. Hafner, C. Ebner, B. K. Ballmer-Weber, A. Knulst, K. Hoffmann-Sommergruber, C. Radauer, A. Mari, and H. Breiteneder. 2011. The performance of a component- based allergen microarray for the diagnosis of kiwifruit allergy. Clin Exp Allergy (41): 129-136. 3. Bulgheresi, S., H. R. Gruber-Vodicka, N. R. Heindl, U. 6,153 Top Dirks, M. Kostadinova, H. Breiteneder, and J. A. Ott. 2011. Sequence variability of the pattern recognition receptor Mermaid mediates specificity of marine nematode symbioses. ISME J (5): 986-998. 4. D'Avino, R., M. L. Bernardi, M. Wallner, P. Palazzo, L. 6,297 Top Camardella, L. Tuppo, C. Alessandri, H. Breiteneder, F. Ferreira, M. A. Ciardiello, and A. Mari. 2011. Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen. Allergy (66): 870-877. 5. Collot, M., I. B. Wilson, M. Bublin, K. Hoffmann- 2,978 St. Sommergruber, and J. M. Mallet. 2011. Synthesis of cross-reactive carbohydrate determinants fragments as tools for in vitro allergy diagnosis. Bioorg Med Chem (19): 1306-1320. 6. Le, T. M., P. Fritsche, M. Bublin, C. Oberhuber, S. Bulley, 9,273 Top E. van Hoffen, B. K. Ballmer-Weber, A. C. Knulst, and K. Hoffmann-Sommergruber. 2011. Differences in the allergenicity of 6 different kiwifruit cultivars analyzed by prick-to-prick testing, open food challenges, and ELISA. J Allergy Clin Immunol (127): 677-679 e671-672. 7. van den Driesche, S., W. Witarski, S. Pastorekova, H. 3,913 Top Breiteneder, C. Hafner, M.J. Vellekoop. 2011. A label-free indicator for tumor cells based on the CH(2)-stretch ratio. Analyst (136): 2397-2402. 8. Latzka, J., S. Gaier, G. Hofstetter, N. Balazs, S. Ferrone, 4,411 Top O. Scheiner, H. Breiteneder, H. Pehamberger, S. Wagner. 2011. Specificity of mimotope-induced anti-high molecular weight melanoma associated antigen (HMW-MAA) antibodies does not ensure biological activity. PLoS One (6): e19383. 9. Wurms, K., W. Cui, A. Ah-Chee, J. Rees-George, M. 0,937 St. Bublin, H. Breiteneder. 2011. Down Regulation of Putative Defence-Associated Transcripts Correlates with Ripe Rot
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Symptoms on Kiwifruit (Actinidia chinensis). J. Phytopathol 159:435-442. 10. Moritz, K. B., T. Kopp, G. Stingl, M. Bublin, H. 0,779 SSt. Breiteneder, and S. Wohrl. 2011. Anaphylaxis to Malaysian meat loaf. Allergol Immunopathol (Madr) (39): 244-245. 11. Sancho, A. I., A. Wangorsch, B. M. Jensen, A. Watson, Y. 4,713 Top Alexeev, P. E. Johnson, A. R. Mackie, A. Neubauer, G. Reese, B. Ballmer-Weber, K. Hoffmann-Sommergruber, P. S. Skov, S. Vieths, and E. N. Mills. 2011. Responsiveness of the major birch allergen Bet v 1 scaffold to the gastric environment: Impact on structure and allergenic activity. Mol Nutr Food Res (55): 1690-1699. 12. Konakovsky, V., M. Focke, K. Hoffmann-Sommergruber, 2,230 St. R. Schmid, O. Scheiner, P. Moser, R. Jarisch, and W. Hemmer. 2011. Levels of histamine and other biogenic amines in high-quality red wines. Food Addit Contam Part A Chem Anal Control Expo Risk Assess (28): 408-416. 13. Mayer, M., C. Oberhuber, I. Loncaric, B. Heissenberger, 1,575 St. M. Keck, O. Scheiner, K. Hoffmann-Sommergruber (corresponding author). 2011. Fireblight (Erwinia amylovora) affects Mal d 1-related allergenicity in apple. Eur J Plant Pathol, (131): 1-7, DOI 10.1007/s10658-011- 9784-4. 14. Worm, M., K. Scherer, A. Kohli-Wiesner, F. Rueff, V. 0,143 SSt. Mahler, L. Lange, R. Treudler, E. Rietschel, Z. Szepfalusi, R. Lang, U. Rabe, T. Reese, N. Schwerk, K. Beyer, S. Hompes, A. Bircher, B. Przybilla, T. Hawranek, G. Hansen, F. Friedrichs, H. Merk, K. Tenbrock, S. Lehmann, M. Gerstlauer, J. Kleine-Tebbe, B. Niggemann, H. Dickel, M. Bucheler, T. Bieber, J. Hanfland, S. Schmitt-Grohe, D. Vlajnic, V. Heckmann, K. Nemat, K. Schakel, A. Nordwig, A. Schuster, S. Schweitzer-Krantz, U. Hillen, M. Kopp, C. Szliska, J. Klinge, I. Neustadter, T. Fuchs, R. Bruns, C. Marsch, B. Kreft, E. Coors, W. Rebien, B. Wedi, C. Pfohler, M. Rett, M. Henzgen, P. Vohringer, R. Folster-Holst, N. Hunzelmann, G. Siebenhaar, S. Nestoris, C. Schirpke, J. Grabbe, G. Stichtenoth, J. Ring, K. Brockow, R. Brehler, I. Yildiz, S. Volkmuth, M. Geissler, M. Polz, F. Riffelmann, S. Thies, U. Lepp, H. Rebmann, T. Spindler, L. Klimek, O. Pfaar, W. Brosi, W. Aberer, E. Varga, N. Reider, I. Huttegger, T. Kinaciyan, K. Hoffmann-Sommergruber, P. Eng, A. Helbling, P. Eigenmann, R. Guggenheim, and P. Schmid-Grendelmeier. 2011. Food-induced anaphylaxis and cofactors - data from the anaphylaxis registry. Allergologie (34): 329-337. 15. Ecker, C., P. Forstenlechner, D. Milić, K. Hoffmann- 0,713 SSt. Sommergruber, M. Cichna-Markl, D. Matković-Čalogović. 2011. Expression, purification and crystallization of wheat profilin (Tri a 12). Croatica Chemica Acta Vol: 84, Issue 3: 419-422. 16. Csupor, D., B. Borcsa, B. Heydel, J. Hohmann, I. Zupkó, Y. 0,672 St. Ma, U. Widowitz, R. Bauer R. 2011. Comparison of a
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specific HPLC determination of toxic aconite alkaloids in processed Radix aconiti with a titration method of total alkaloids. Pharm Biol. 49 (10):1097-1101. 17. Chruszcz, M., Maleki, S. J., Majorek, K. A., Demas, M., 5,328 Top Bublin, M., Solberg, R., Hurlburt, B. K., Ruan, S., Mattison, C. B., Breiteneder, H., and W. Minor. Structural and immunologic characterization of Ara h 1 – a major peanut allergen. J Biol Chem 2011;286(45):39318-27. sum 57,226
b) Invited Articles & Reviews with IF: n = 2
Nr. Article IF Class 1. Ballmer-Weber, B. K., and K. Hoffmann-Sommergruber. 3,431 St. 2011. Molecular diagnosis of fruit and vegetable allergy. Curr Opin Allergy Clin Immunol (11): 229-235. 2. Hoffmann-Sommergruber, K., K. Paschinger, and I. B. 3,989 St. Wilson. 2011. Glycomarkers in parasitic infections and allergy. Biochem Soc Trans (39): 360-364. sum 7,420 c) Invited Articles & Reviews without IF: n = 0 d) Book contributions: n = 0 e) Abstracts, printed in periodicals: n = 11
1. van den Driesche, S., W. Witarski, S. Pastorekova, H. Breiteneder, C. Hafner, M.J. Vellekoop. 2011. A label-free indicator for tumor cells based on the CH(2)-stretch ratio. J Invest Dermatol (131): 123. 2. Somkuti, J., M. Bublin, H. Breiteneder, L. Smeller. 2011. Unfolding of the cod parvalbumin Gad m 1 allergen by high pressure. Eur Biophys J Biophy (40): 60. 3. Ackerbauer, D., B. Gepp, W. Hemmer, M. Bublin, H. Breiteneder. 2011. Recombinant scFv antibodies against chimeric proteins of Bet v 1 and Api g 1 for IgE epitope mapping. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 723 4. Smole, U., N. Balazs, Y. Sobanov, C. Radauer, M. Bublin, K. Hoffmann- Sommergruber, E. Jensen-Jarolim, D. Mechtcheriakova, H. Breiteneder. Lipid raft mediated uptake of the major birch pollen allergen Bet v 1.0101 activates Th2 polarising signaling pathways in dendritic cells of allergic donors. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 54 5. Wallner, M., H. Michael, M. Himly, S. Wagner, C. Asam, U. Pichler, R. Sanovic, H. Breiteneder, J. Thalhammer, P. Lackner, A. Hartl, F. Ferreira. Non-allergenic structural homologues of Bet v 1 may help to unravel the mystery of allergenicity. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 92. 6. Gepp B., Balazs N., Hemmer W., Radauer C., Breiteneder H. Epitope grafting reveals patient specific IgE binding profiles to the major birch pollen allergen Bet v 1. 30th
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Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 99. 7. Nandy, A., F. Ferreira, H. Breiteneder, A. Pomés. A bioinformatics approach to allergen nomenclature applied to the group 1 ragweed allergens: Amb a 2 renamed as Amb a 1.05. 30th Congress of the European Academy of Allergy and Clinical Immunology. Istanbul, Turkey, June 11-15, 2011. Allergy 66 suppl. 94: 143. 8. Guhsl, E., B. Gepp, N. Balazs, G. Hofstetter, W. Hemmer, H. Breiteneder, C. Radauer. IgE cross-reactivity between Bet v 1 and cytokinin-specific binding protein from mung bean, a homologous protein outside the PR-10 subfamily. 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11- 15, 2011. Allergy 66 suppl. 94: 521. 9. Marchart, K., J. Schinnerl, K. Peter, H. Breiteneder, Y. Ma. 2011. Qualitative analysis of Chinese medical herbs for the prevention and therapy of age related diseases. Die Ernährung/Nutrition. 2011 Oct;35(10):387. 10. Ma, Y., K. Peter, J. Liu, J. Schinnerl, D. Shi, H. Breiteneder. 2011. Traditional Chinese herbal medicine for prevention and therapy of heart failure. Die Ernährung/Nutrition. 2011 Oct;35(10):387-388. 11. Teubl, R., T. Founé, Y. Ma. 2011. Acceptance of Traditional Chinese Medicine in the treatment of obesity and metabolic disorders in western medicine. Die Ernährung/Nutrition. 2011 Oct; 35(10):389. f) Abstracts, in congress proceedings or abstract books: n = 16
66. Gepp B., N. Balazs, W. Hemmer , C. Radauer, H. Breiteneder. Epitope grafting reveals patient specific IgE binding profiles to the major birch pollen allergen Bet v 1. 7th PhD Symposium, Vienna, Austria, June 15-16, 2011 67. Gepp B., N. Lengger, W. Hemmer, C. Radauer, H. Breiteneder. Grafting of Bet v 1 epitopes onto its homologue Api g 1 reveals patient-specific IgE recognition profiles. ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 15. 68. Guhsl E., B. Gepp, G. Hofstetter, N. Lengger, W. Hemmer, H. Breiteneder, C. Radauer. IgE cross-reactivity between Bet v 1 and the mung bean proteins cytokinin- specific binding protein and Vig r 1 in patients with birch pollen-associated allergy to mung bean sprouts. ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 19. 69. Smole U., N. Balazs, C. Radauer, Sobanov Y., M. Bublin, S. Gaier, K. Hoffmann- Sommergruber, E. Jensen-Jarolim, D. Mechtcheriakova, H. Breiteneder. Allergic sensitization to the major birch pollen allergen Bet v 1.0101 – a result of differential signal processing and signal translation in dendritic cells of allergic and healthy individuals? ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 46. 70. Berneder M., S. Claus, M. Worm, K. Hoffmann-Sommergruber K. Food anaphylaxis diagnosis using the allergen CHIP approach. ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 5. 71. Hoflehner E., K. Hufnagl, I. Schabussova, K. Hoffmann-Sommergruber, B. Bohle and U. Wiedermann. ÖGAI 2011 – Annual meeting of the Austrian Society of Allergy and Immunology, Graz, Austria, September 15-17, 2011. 21. 72. Gepp B., N. Lengger, W. Hemmer, C. Radauer, H. Breiteneder. Grafting of Bet v 1 epitopes onto its homologue Api g 1 reveals patient-specific IgE recognition profiles.
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WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011. 73. Radauer C., E. Guhsl, M. Bublin, H. Breiteneder. Pollen Allergens Differ From Non- Allergenic Pollen Proteins by Their Lower Extent of Evolutionary Conservation. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011. 74. Breiteneder H., P. Rozynek, M. Raulf-Heimsoth, R. Goodman and C. Radauer. Bioinformatic Approach to Allergen Nomenclature Applied to Allergens From the Non- Biting Midge Chironomus Thummi Thummi. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011. 75. Guhsl E., B. Gepp, G. Hofstetter, N. Balazs, W. Hemmer, H. Breiteneder and C. Radauer. IgE From Birch Pollen Allergic Patients Cross-Reacts with Two Distinct Bet v 1 Related Proteins in Mung Beans: Vig r 1 and Cytokinin-Specific Binding Protein. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011. 76. Smole U., N. Balazs, C. Radauer, Y. Sobanov, M. Bublin, S. Gaier, K. Hoffmann- Sommergruber, E. Jensen-Jarolim, D. Mechtcheriakova and H. Breiteneder. Specific Recognition of the Major Birch Pollen Allergen Bet v 1 Programs Dendritic Cells to Induce Either Th2 or Tolerogenic Responses. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011. 77. Bublin M., M Kostadinova, D Ackerbauer, C Ebner, C Radauer and H. Breiteneder. Recombinant Scfv Antibodies for IgE Epitope Mapping and Detection of Parvalbumins. WAC 2011 – XXII World Allergy Congress, Cancun, Mexico, December 4-8, 2011. 78. Ma Y. Development of a Curriculum for Chinese Medicine Education at the Medical University of Vienna. 2nd World Education Congress of Chinese Medicine, Beijing, China, October 29-31, 2011. 79. Forstenlechner P., Hoffmann-Sommergruber K., Milić D., Matković-Čalogović D., Ecker C., Cichna-Markl M. Expression, purification and crystallization of wheat profilin (Tri a 12). EAACI Food Allergy and Anaphylaxis Meeting FAAM February 17–19 2011, Venice, Italy. 80. Hoffmann-Sommergruber K., Gehört es schon zum guten Ton? Allergieneigung und Häufigkeit in der Bevölkerung. Jahrestagung des Verbandes der Ernährungswissenschafter Österreichs: 5.5.2011, BM für Gesundheit; Vienna, Austria. 81. Hoffmann-Sommergruber K., Neue Nahrungsmittelallergene“ und deren Relevanz 24. Allergie-Kolloquium am 7. Mai 2011, Forschungszentrum Borstel, Germany. g) Teaching Scripts and Books, n = 28
Breiteneder Heimo Lehrunterlagen für die Vorlesung Nahrungsmittelallergie 502.362, VO 2 St. 1. Skriptum - Nahrungsmittelallergene: Proteinfamilien und Kreuzreaktivitäten, Teil A 2. Skriptum - Nahrungsmittelallergene: Proteinfamilien und Kreuzreaktivitäten, Teil B 3. Skriptum - Gentechnisch veränderte Nahrungsmittel und Allergie 4. Skriptum – Physikalische chemische Eigenschaften von Nahrungsmittelallergenen
Bublin Merima:
Lehrunterlagen für die Vorlesung Nahrungsmittelallergie 502.362, VO 2 St. 1. Das mukosale I(mmunsystem) 2. IgE-vermittelte Nahrungsmittelallergie: Epidemiologie, Symptome, Diagnose, Therapie, Prävention 3. Nicht IgE-vermittelte Nahrungsmittelunverträglichkeiten 4. Methoden zur Identifizierung und Charakterisierung von Nahrungsmittelallergenen
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Hoffmann-Sommergruber Karin:
Lehrunterlagen für die Vorlesung NM-Allergien und Intoleranzen 514.074 NM Allergien und Intoleranzen (gemeinsam mit Priv. Doz. Dr. Merima Bublin) VO 2 St. 1. Einführung: Immunsystem, Grundlagen und Pathomechanismus der allergischen Reaktion 2. NM Allergien: Symptome, Prävalenz 3. Allergene 4. Diagnostik von NM-Allergien und Fallbeispiele 5. NM-Intoxikationen, Immunmediierte NM-Allergien - Zöliakie; NM- Intoleranzen; Fallbeispiele 6. NM Allergien: Genetische Aspekte; Umwelteinflüsse bei Allergieentstehung; Hygienehypothese 7. Präventionsmaßnahmen: Allergenkennzeichnung 8. NM-Allergien: Therapienansätze Lehrunterlagen für die Vorlesung Ausgewählte Kapitel der medizinischen Biotechnologie 648.401 (gem. mit . Doz. Wagner, Doz. Radauer, Pro .Breiteneder und Doz Bublin) VO 2 St. 1. Vakzine und Adjuvantien 2. GM-Food 3. GM-Food and PMPs
Radauer Christian:
Lehrunterlagen für die Vorlesung Nahrungsmittelallergie 502.362, VO 2 St. 1. Skriptum: Molekulare und zelluläre Grundlagen der IgE-vermittelten Allergie 2. Skriptum: Ursachen allergischer Erkrankungen 3. Skriptum: Probleme in der Allergiediagnostik; Allergene und Kreuzreaktionen pflanzlicher und tierischer Nahrungsmittel 4. Skriptum: Allergenität verarbeiteter Nahrungsmittel; Versteckte Allergene und Lebensmittelkennzeichnung Lernunterlagen für die Vorlesung "Ausgewählte Kapitel der medizinischen Biotechnologie"; 648.401; VO 2 St. 1. Skriptum: Design von Antikörperderivaten für Diagnostik und Therapie 2. Skriptum: Kombinatorische Methoden zur Entwicklung neuer Wirkstoffe
Wagner Stefan:
Lernunterlagen für die Vorlesung "Ausgewählte Kapitel der medizinischen Biotechnologie"; 648.401; VO 2 St. 1. Immuntherapie von Krebserkrankungen mit monoklonalen Antikörpern 2. Immuntherapie von Krebserkrankungen auf zellulärer Basis 3. Sonstige Ansätze zur Immuntherapie von Krebserkrankungen h) Articles in Medical Journals: n = 1
Breiteneder Heimo:
1. Ärzte Woche, Professur für Medizinische Biotechnologie, .Ärzte Woche 21/2011.
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i) Public Activity: n = 9
Breiteneder Heimo: 1. Medizinische Universität Wien, Heimo Breiteneder: „Pionier der Allergenforschung“ erhält Professur für Medizinische Biotechnologie, http://www.meduniwien.ac.at/homepage/news-und- topstories/?tx_ttnews[tt_news]=1892&cHash=b4615a5848, Wien 05/17/2011. 2. SpringerMedizin.at, Breiteneder wird Biotech-Professor der MedUni Wien, http://www.springermedizin.at/artikel/22227-breiteneder-wird-biotech-professor- der-meduni-wien, 05/17/2011. 3. I.G.A.V., „Pionier der Allergenforschung“ erhält Professur für Medizinische Biotechnologie, http://www.allergenvermeidung.org/index.php?aid=387, 5/2011. 4. Studium.at Der Online-Tutor, „Pionier der Allergenforschung“ erhält Professur für Medizinische Biotechnologie, http://www.studium.at/45155-pionier-der- allergenforschung-erhaelt-professur-fuer-medizinische-biotechnologie-der- meduni-wien, 05/17/2011. 5. APA, Breiteneder wird Biotech-Professor der MedUni Wien, http://www.zukunftwissen.apa.at/cms/zukunft-wissen/fti-und- wissenschaft/zukunft-wissen-topnews.pdf?id=CMS1305627557234, 5/2011. 6. Zentrum für Pathophysiologie, Infektiologie und Immunologie, Heimo Breiteneder Professor für Medizinische Biotechnologie, http://www.meduniwien.ac.at/hp/cepii/news/singleview/heimo-breiteneder- professor-fuer-medizinische-biotechnologie/f8ebe5dc42/, 5/2011. 7. Lebensweise-Magazin, Allergie-Frust statt Frühlingslust, http://www.lebensweise- magazin.at/2011/03/11/allergie-frust-statt-fr%C3%BChlings-lust/ 08/03/2011. 8. AlumniClubMUW auf Twitter, „Pionier der Allergenforschung“ erhält Professur für Medizinische Biotechnologie, http://twitter.com/#!/AlumniClubMUW/status/70523920322789376, 05/17/2011. Ma Yan: 1. People Magazin Ausgabe 01/2011: Menschen und Medizin im Wiener AKH. Erster TCM-Lehrgang gestartet, S.6.
1.4.2. Research Awards: n = 10
Ackerbauer Daniela: 1. Poster Prize at the EAACI 2011 – 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. 2. Poster Prize, 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology at the Medical University of Vienna, Sept. 27, 2011. Gepp Barbara: 3. Junior Poster Prize at the EAACI 2011 – 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. 4. Poster Prize of the Austrian Society of Allergology and Immunology (ÖGAI), Annual Meeting of the Austrian Society of Allergology and Immunology, Graz 2011. 5. Travel Grant of the World Allergy Organization (WAO), 22nd World Allergy Congress in Cancun, Mexico, 4-8 December, 2011.
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Guhsl Eva: 6. Poster Prize, 2nd Retreat of the Center for Pathophysiology, Infectiology and Immunology at the Medical University of Vienna, Sept. 27, 2011. 7. Travel grant of the ÖGAI (Austrian Society for Allergology und Immunology) for the 22nd WAO Congress 2012 in Cancun, Mexico, December 04-08, 2011. Smole Ursula: 8. Travel grant of the European Academy of Allergy and Clinical Immunology, 30th Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, Turkey, June 11-15, 2011. 9. Travel grant of the World Allergy Organization for the 22nd World Allergy Congress, Cancun, Mexico, December 4-8, 2011. 10. WAO Junior Abstract Award of the World Allergy Organization for the 22nd World Allergy Congress, Cancun, Mexico, December 4-8, 2011.
1.4.3. Invited lectures: n = 27
Breiteneder Heimo:
1. Wiener Allergiekurs 2011. „Allergene und Allergenquellen“. 1/28/2011, Hotel Strudlhof Vienna, Austria. 2. 6. Tiroler Allergietagung. Gentechnik & Allergologie – Konsequenzen für den Nahrungsmittelallergiker. 3/26/2011, Villa Blanka, Innsbruck, Austria. 3. 30th Congress of the European Academy of Allergy and Clinical Immunology (EAACI). Latex allergy – New molecules in diagnosis and cross-reactivity. 6/15/2011, Istanbul, Turkey. 4. Immunity in cancer & allergy symposium. What makes proteins allergenic? 7/1/2011, University Salzburg, Austria. 5. Allergietag zum Thema: „Molekulare Allergiediagnostik mittels Chiptechnologie: Anwendung & Interpretation.“ Grundlagen der molekularen Allergiediagnostik. 11/5/2011, Wilhelminenspital Vienna, Austria. 6. Workshop: Molekulare Allergologie. Allergene: Definition, Nomenklatur und Datenbanken. 11/18/2011, Arcotel Kaiserwasser Vienna, Austria. 7. XXII World Allergy Congress. A bioinformatic approach to allergen nomenclature applied to allergens from the non-biting midge Chironomus thummi thummi. 12/5/2011, Cancun, Mexico.
Hoffmann-Sommergruber Karin:
1. EAACI Food Allergy and Anaphylaxis Meeting (FAAM). Food Allergen protein families and their structural characteristics: New data from EuroPrevall at Workshop 7: Characterisation of Food Allergens and clinical Implications. 2/18/2011, Venice, Italy. 2. VEÖ: Jahrestagung des Verbandes der Ernährungswissenschafter Österreichs: „Gehört es schon zum guten Ton? Allergieneigung und Häufigkeit in der Bevölkerung“. 5/5/2011, BM für Gesundheit; Vienna, Austria. 3. 24. Allergie-Kolloquium Forschungszentrum Borstel. Neue Nahrungsmittelallergene und deren Relevanz. 5/7/2011, Forschungszentrum Borstel, Germany. 4. 30th Congress of the European Academy of Allergy and Clinical Immunology. Food. Allergy: “Emerging allergens – new ones and old friends revisited”. Symposium on Food Allergy. 6/15/2011, Istanbul, Turkey.
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5. 30th Congress of the European Academy of Allergy and Clinical Immunology. “Determining the clinical relevance of allergen food-cross reactivity: Food-Food versus Food- Pollen”. 6/11/2011, Istanbul, Turkey. 6. 30th Congress of the European Academy of Allergy and Clinical Immunology. Introductory lecture: New recombinants in the diagnosis of food Allergy, Oral Abstract session. 6/13/2011, Istanbul, Turkey. 7. Ernährungsakademie: Gentechnisch veränderte Lebensmittel: Vermeidbares Risiko oder Segen für den Konsumenten? 9/17/2011, Vienna, Austria. 8. Weiterbildung Fachtoxikologe/Fachtoxikologie DGPT, Kurs „Lebensmitteltoxikologie“. Lebensmittelallergien und Unverträglichkeiten. 10/14/2011, TU Kaiserslautern, Kaiserslautern, Germany. 9. Allergietag zum Thema: „Molekulare Allergiediagnostik mittels Chiptechnologie: Anwendung & Interpretation: Allergenchip: Pro und Contra: Dermatol. Abteilung Wilhelminenspital. 11/5/2011, Vienna, Austria. 10. Advanced Therapies Gene therapy and recombinant proteins (FH Krems, within Master studies regulatory affairs, 12/17/2011, Krems, Austria. 11. Science Day – MedUniWien: “Allergisch aufs Essen??“ Vortrag und Poster im Rahmen des Science Day, 10/7/2011, Vienna, Austria.
Ma Yan:
1. Effects of a traditional Chinese herbal medicine formula on myocardial infarction in a rat model. TCMIRI - MEETING, 04/28/2011, China-Zentrum der Universität Salzburg, Austria. 2. Effects of Si Ni Tang, a Chinese Medical Formula, on Early Cardiac Remodeling in Rats, Post-acute Myocardial Infarction. TCM Evaluierungsmeeting an der China Academy of Chinese Medical Sciences in Zusammenarbeit mit BMWF und BMG, 05/30/2011, Beijing, China. 3. Quality control of Chinese medical herbs for the prevention and therapy of age related diseases. Workshop "Quality Requirements of Herbal Drugs and Herbal Medicinal Products" 06/01/2011, Beijing, China. 4. Warum wird in der Traditionellen Chinesischen Medizin nicht operiert? 07/18/2011, KinderUni 2011, Vienna, Austria. 5. Development of a Curriculum for Chinese Medicine Education at the Medical University of Vienna. 2nd World Education Congress of Chinese Medicine, 10/29/2011, Beijing, China.
Radauer Christian:
1. Pirquet-Club, organized by the Austrian Society of Allergology and Immunology. "Das Latex-Frucht-Syndrom: Neue Daten zum molekularen Hintergrund" 2/21/2011, Vienna, Austria. 2. Seminar Nahrungsmittelallergien 2011, Veranstaltet vom Verband der Diätologen Österreichs. Allergene und Kreuzreaktionen pflanzlicher und tierischer Nahrungsmittel. 10/20/2011, Salzburg, Austria.
Wagner Stefan:
1. "Erfahrungen mit Tiermodellen für humane Melanome". ÖAW-Symposium "Das Melanom - der 'schwarze Tod' der Neuzeit". Veterinärmedizinische Universität. 07/20/2011, Vienna, Austria. 2. "Auswirkungen der Umsetzung eines Qualitätsmanagementsystems nach ISO 9001:2008 an einem Forschungsinstitut". Naturwissenschaftliche Fakultät, Universität Salzburg. 11/15/2011, Salzburg, Austria.
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1.4.4. Congress organization
Division member National congress Intern. Congress, Function Function Name: Name, date Name, date Hoffmann- EAACI Food Allergy and Member of the Sommergruber Anaphylaxis Meeting Organising Karin FAAM February 17 – 19 Committee 2011, Venice, Italy.
1.4.5. Hosting speakers
division member Speaker´s name Affiliation Date Ma Yan Prof. Dr. Zhao Beijing University of Chinese 04/12/2011 – Yansong Medicine & Pharmacology 07/31/2011 Ma Yan Prof. Dr. Liu Min Beijing University of Chinese 02/19/2011 – Medicine 05/19/2011 Ma Yan Dr. Su Rui China Academy of Chinese Medicine 09/12/2011 - Sciences 16/12/2011 Ma Yan Prof. Dr. Chang Beijing University of Chinese 12/01/2011 – Jingling Medicine 02/29/2012
1.4.6. Mobility
Name Program University, Land Time frame Division In Out Alcocer Marcos Sabbatical University 04/04/2011 – 4 X Nottingham, UK 04/20/2011 Ashjaei Kazem Financial supported Tabriz University 04/19/2010 – 4 X by the Tabriz of Medical 06/30/2013 University of Medical Sciences, Iran Sciences, Iran Liu Min Eurasia-Pacific Uninet University of TCM 02/19/2011 – 4 X Scholarship Award Beijing, China 05/19/2011 Zhao Yansong Eurasia-Pacific Uninet University of 04/12/2011 – 4 X Scholarship Award Beijing, China 07/31/2011 Chang Jingling Eurasia-Pacific Uninet University of 12/01/2011 – 4 X Scholarship Award Beijing, China 02/29/2012
1.4.7. Activities in Advisory Boards
Name Society/Institute/Journal Function Breiteneder Heimo International Union of Chair and Member Immunological Societies, Allergen Nomenclature Sub- committee
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Breiteneder Heimo International Union of Member Immunological Societies, Allergen Standardization Sub- committee Breiteneder Heimo AllFam Database of Allergen Member of Scientific Advisory Families Board Breiteneder Heimo SDAP Structural Database of Member of Scientific Advisory Allergenic Proteins Board Bublin Merima AllFam Database of Allergen Member of Scientific Advisory Families Board Hoffmann-Sommergruber Karin IG Food Allergy Chair Hoffmann-Sommergruber Karin Pirquet Club Scientific secretary Ma Yan Consortium for Globalization of Expert of Education Session Chinese Medicine Ma Yan World Federation of Chinese Member of Cardiovascular Medicine Specialist Committee Ma Yan The World Federation of Member of Testing and Chinese Medicine Societies Assessment Committee Ma Yan Eurasia-Pacific Uninet Represent Member of Board of Directors Ma Yan ASEAN-European Academic Represent Member of Board of University Network Directors Ma Yan Austrian Society for Medical Member of the Scientific Council Anthropology Ma Yan TCM Research Cluster Austria Member of the Scientific Council Radauer Christian International Union of Member Immunological Societies, Allergen Nomenclature Sub- committee Radauer Christian AllFam Database of Allergen Project Manager and Families Administrator Wagner Stefan AllFam Database of Allergen Member of Scientific Advisory Families Board
1.4.8. Editorial Activities
Name Journal Function Breiteneder Heimo International Archives of Allergy Member of Editorial Board and Immunology Breiteneder Heimo Allergy Member of Editorial Board Hoffmann-Sommergruber Karin International Archives of Allergy Member of Editorial Board and Immunology
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1.4.9. Review Activities
Name Grants/Thesis/Habilitation Heimo Breiteneder Doctoral Thesis Sonja Gaier Heimo Breiteneder Doctoral Thesis Ursula Smole Hoffmann-Sommergruber Karin Doctoral Thesis Sofia Sirvent, Madrid, E, 2011 Hoffmann-Sommergruber Karin HESI-ILSI Report: on: IFBiC Task Force 10;
1.4.10. Filed and granted patents
Name Patent
1.4.11. Grants
Funding agency Title of project Principal investigator FWF-SFB Molecular, immunological and structural characterization, Heimo Breiteneder and modifications of plant-food and latex allergens for diagnosis, prevention and specific immunotherapy. FFG Strukturelles Engineering der Hauptallergene der Erdnuss für Heimo Breiteneder die allergenspezifische Immuntherapie. European Biomedical engineering for cancer and brain disease Heimo Breiteneder Community diagnosis and therapy development.
FWF-SFB Molecular, immunological and structural characterization and Heimo Breiteneder modifications of plant-food and latex allergens for diagnosis, prevention and specific immunotherapy. Roche Austria The effect of mimotope vaccine induced antibodies specific Heimo Breiteneder GmbH for CSPG4 and BRAF inhibitor on melanoma cells. Padia Reinigung und Charakterisierung von 5 mg des Heimo Breiteneder Walnussallergens Jug r 2. FWF Conformational immunoglobulin E epitopes of Bet v 1. Christian Radauer WKO Wien Allergenchips für Diagnose von Lebensmittelanaphylaxie. Karin Hoffmann- Sommergruber Bundesministerium TCM and Age Related Diseases. Yan Ma für Gesundheit, Familie und Jugend (BMGFJ) / Bundesministerium für Wissenschaft und Forschung (BMWF) Medizinische Universitätslehrgang Grundlagen und Praxis der TCM. Yan Ma Universität Wien Medizinische Universitätslehrgang Grundlagen und Praxis der TCM Yan Ma Universität Wien Nachtrag. Eurasia Pacific TCMIRI - MEETING, China-Zentrum der Universität Yan Ma Uninet Salzburg. Eurasia Pacific TCM Evaluierungsmeeting an der China Academy of Yan Ma Uninet Chinese Medical Sciences in Beijing. European Informationskonzept für Patienten/Konsumenten zu Yan Ma Community EDQM Anwendungen der TCM. OEAD Technologiestipendien Ost- / Zentral- / Südasien (Postdoc) Yan Ma (Chang)
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OEAD Technologiestipendien Ost- / Zentral- / Südasien (Postdoc) Yan Ma (Liu) OEAD Technologiestipendien Ost- / Zentral- / Südasien (Postdoc) Yan Ma (Zhao)
1.4.12. Career Developments a) Habilitations: n = 0 b) Habilitations in progress: n = 0 c) Professorships: n = 1
Breiteneder Heimo 01/05/2011, Medical Biotechnology d) Qualification Agreement: n = 0
1.4.13. Teaching
Wahlbeispiele und Schulpraktika
Altmann Johanna: Reinigung von Ber e 1, aus Paranuss. Wahlbeispiel f. Mol Biologie, Uni Wien, 1. Juli – 31. Juli 2011.
Milanovic Sveta: Austesten von kolloidalem Coomassie für Gelfärbung. Schulpraktikum, HBLVA, Rosensteingasse, 1. Juli – 31. Juli 2011. a) Bachelor students: n = 3
Limberger Tanja: Isolation, Purification and characterization of Jug r 4, a seed storage protein from walnut. (Wahlbeispiel/BachelorArbeit f. Biotechnologie, BOKU), 4. April - 13. Mai 2011. Stary Tamara: Extraction, Purification and Identification of Jug r 3, the non specific Lipid Transfer protein from Walnut (Juglans regia). FH Technikum Wien, 10. Jänner – 22. 4. 2011. Huber Benjamin: Gewinnung und Charakterisierung von rekombinanten Antikörpern gegen Nahrungsmittelallergene. FH- Campus Wien, (Applied Life Sciences), 10. Jänner – 27. 5. 2011.
b) Diploma, MDiploma and Master students: n = 8
Ackerbauer Daniela: Diploma thesis. Generation of recombinant human single chain antibodies against inhalative and food allergens using phage display. (10/2010 – in progress). Christiane Agreiter: Purification of lipid transfer proteins and 2S albumins from tree nuts and peanut and their range of cross-reactivity – implication for the nut allergic patient. (10/2011 - in progress). Berneder Maria:
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Diploma thesis. From the allergic sensitization to the effector phase: Methods to follow allergen uptake by dendritic cells, allergen characterization and evaluation of allergen chips . (01/2011 – in progress). Founé Tanja: Diploma thesis. Inwieweit wird die Traditionelle Chinesische Medizin in der Behandlungsmethode des metabolischen Syndroms in der westlichen Medizin akzeptiert? (15.12.2011). Hinterhölzl Elisabeth: Diploma thesis. Effects of acupuncture on chronic non-specific back pain. (11/2010 – in progress). Kühebacher Maria: Diploma thesis. Reinigung und immunologische Charakterisierung des Lipid Transfer proteins Cor a 8 und komponentenspezifische Allergiediagnostik bei Haselnussallergikern. (04/2011 – in progress). Marchart Kristina: Diploma thesis. Qualitative und quantitative analysis of Chinese medical herbs for the prevention and therapy of acute myocardial infarction and diabetes. (30.11.2011). Teubl Roswitha: Diploma thesis. Inwieweit wird die Traditionelle Chinesische Medizin in der Behandlungsmethode des metabolischen Syndrom in der westlichen Medizin akzeptiert? (15.12.2011). c) PhD, MDSci, MD students: n = 7
Ashjaei Kazem: PhD thesis. Influence of allergens on human dendritic and basophil cells. (4/2010 – in progress). Gaier Sonja: PhD thesis. Generation of a polymimotope vaccine against malignant melanoma. (7.3.2011). Gepp Barbara: PhD thesis. Identification of allergenic determinants of Bet v 1 homologs using dendritic cells as read-out system. (4/2010 – in progress). Guhsl Eva: PhD thesis. Identification of conformational immunoglobulin E epitopes of the major birch pollen allergen, Bet v 1: their cross-reactivities and clinical relevance in the birch pollen-plant food syndrome. (10/2010 – in progress). Peter Karoline: PhD thesis. Effects of traditional Chinese herbal medicine on age related diseases (10/2009 – in progress). Kostadinova Maria: PhD thesis: Entwicklung einer Vakzine gegen Erdnussallergie. (3/2009 – in progress). Smole Ursula: PhD thesis. The interaction of allergenic and non-allergenic Bet v 1 homologues with human dendritic cells. (13.5.2011).
1.4.14. Exams a) Oral examinations n = 28
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Bublin Merima n = 4 Hoffmann-Sommergruber Karin n = 4 Ma Yan n = 20 b) Diploma and Thesis-Examinations: n = 7
Breiteneder Heimo: Gaier Sonja. Thesis-Examination. Examiner. 03/07/2011. Smole Ursula. Thesis-Examination. Examiner. 05/13/2011. Hoffmann-Sommergruber Karin: Arthold Susanne. Diploma Examination. Examiner. 12/13/2011. Ma Yan: Founé Tanja. Diploma-Examination. 12/15/2011. Teubl Roswitha. Diploma-Examination. 12/15/2011. Marchart Kristina. Diploma-Examination. 11/30/2011. Radauer Christian: Gaier Sonja. Thesis-Examination. Examiner. 03/07/2011. c) Exam supervising: n = 4
Hoffmann-Sommergruber Karin. SIP. 04/12/2011. Hoffmann-Sommergruber Karin. Beisitz Kommissionelle Prüfung. 05/16/2011. Hoffmann-Sommergruber Karin. Beisitz Kommissionelle Prüfung Funkt Pathophysiologie (Nostrifizierung) 11/11/2011.
Radauer Christian. SIP 5, 07/04/2011.
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1.4.15. Lectures, Seminars, Lab courses
SWST pro-rata LV Nr. SS 2011 Breiteneder Heimo 2,00 0,40 648.401 Ausgewählte Kapitel der medizinische Biotechnologie Breiteneder Heimo 2,00 2,00 514.057 Dissertanten- und Diplomandenseminar: Anleitung zu Wissenschaftlichen Arbeiten Breiteneder Heimo 2,00 2,00 901.768 Journal Club und Progress Report Hoffmann-Sommergruber Karin 4,00 0,50 808.004 SSM 3-Projektstudie (Wahlpflichtteil) Hoffmann-Sommergruber Karin 2,00 0,40 648.401 Ausgewählte Kapitel der medizinische Biotechnologie Hoffmann-Sommergruber Karin 2,00 1,00 514.074 Nahrungsmittelallergien und -Intoleranzen Hoffmann-Sommergruber Karin 2,00 2,00 648.037 Journal Club und Progress Report Wagner Stefan 1,00 1,00 652.000 Senior-Mentoring Humanmedizin Wagner Stefan 2,00 0,40 648.401 Ausgewählte Kapitel der medizinische Biotechnologie Ma Yan 4,00 0,50 808.004 SSM 3-Projektstudie (Wahlpflichtteil) Ma Yan 0,50 0,50 891.007 M1 - Einführung in die Medizinische chinesische Fachsprache und Kultur (1) Ma Yan 0,40 0,60 891.008 Kaisers Kanon der Medizin Ma Yan 0,40 0,60 891.009 Abhandlung von exogenen fieberhaften Krankheiten Ma Yan 2,67 3,20 891.011 Klinische Observation Ma Yan 2,27 2,72 891.017 Chinesische Materia Medica Ma Yan 0,93 1,12 891.018 Einführung in die Rezeptkunde der TCM Ma Yan 0,27 0,32 891.019 Synopsis der Goldenen Kammer Ma Yan 0,54 0,64 891.020 Saisonale fieberhafte Erkrankungen Ma Yan 0,54 0,64 891.021 Forschung in der TCM Radauer Christian 2,00 0,40 648.401 Ausgewählte Kapitel der medizinische Biotechnologie Bublin Merima 2,00 1,00 514.074 Nahrungsmittelallergien und -Intoleranzen Sum 21,94 WS 2011/12 Breiteneder Heimo 2,00 0,60 502.362 Nahrungsmittelallergie Breiteneder Heimo 2,00 2,00 514.057 Dissertanten- und Diplomandenseminar: Anleitung zu Wissenschaftlichen Arbeiten Breiteneder Heimo 1,00 1,00 514.073 Neueste molekularbiologische Techniken - (Privatissimum) Breiteneder Heimo 2,00 2,00 648.007 Journal Club and Progress Report Hoffmann-Sommergruber Karin 2,00 0,70 502.362 Nahrungsmittelallergie Hoffmann-Sommergruber Karin 2,00 2,00 648.008 Journal Club und Progress Report
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Hoffmann-Sommergruber Karin 2,00 2,00 648.009 Anleitungen zu wiss. Arbeiten Hoffmann-Sommergruber Karin 2,20 0,53 803.003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Ma Yan 0,67 1,00 891.009 Einführung in die Medizinische chinesische Fachsprache und Kultur (3) Ma Yan 0,50 0,50 891.007 M2 - Einführung in die Medizinische chinesische Fachsprache und Kultur (2) Ma Yan 2,67 4,00 891.013 Akupunktur-Behandlung und Moxibustion Ma Yan 1,34 2,00 891.015 Innere Medizin in der TCM Ma Yan 0,67 1,00 891.016 Experimentelle Akupunktur Ma Yan 0,13 0,20 891.017 Klassische Literatur der Akupunktur und Moxibustion Ma Yan 2,67 4,00 891.018 Klinische Observation in China oder in Österreich Radauer Christian 2,00 0,70 502.362 Nahrungsmittelallergie Radauer Christian 2,20 0,53 803.003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Sum 24,76 Total sum SS+WS 46,70
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