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November 2004 NOVEMBER 2004 www.asbmb.org Constituent Society of FASEB AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY ALSO IN THIS ISSUE ASBMB Comments on NIH Public Access Notice Page 5 AxelAxel andand BuckBuck AAwardedwarded 20042004 NobelNobel PrizePrize SAN DIEGO 2005: Call for Late-Breaking Abstracts see page 5 Custom Peptides with 2. 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Let our enthusiasm for science work for you! www.21stcenturybio.com P 508.303.8222 Toll-free: 877.217.8238F 508.303.8333E www.asbmb.org AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY NOVEMBER 2004, Volume 3, Issue 8 features 5 ASBMB Comments on NIH Public Access Notice 6 Senate Hearing on Stem Cell Controversy 7 Congress Adjourns; Lame Duck Session Coming 8 Lasker Award Goes to Elwood Jensen 20 10 Pharmacological Chaperones 14 Coordinate Regulation of Transcription ON THE COVER: 16 Catalysis: Structure, Function, and Evolution 12 Axel, Buck 19 William Dowhan to Get Avanti Award Awarded 2004 Nobel 20 Jack Dixon to Receive ASBMB-Merck Award 22 Jan-Åke Gustafsson Wins Bristol-Myers Squibb 23 JBC Launches Papers of the Week 26 Steven McKnight Wins NIH Award AWARDS OF EXCELLENCE: MOST IMPROVED MAGAZINE 10 COLUMNS & EDITORIALS DESIGN & LAYOUT departments 2 Letters 6 News From the Hill 26 NIH News 28 Biotech Business 31 Career Opportunities BRONZE AWARD WINNER 2003 32 Calendar LETTERS ASBMB Council Officers Judith S. Bond President Bettie Sue Masters Past-President Peggy J. Farnham Secretary Kenneth E. Neet Treasurer Council Members William R. Brinkley Councilor State Dept. Official Sees Joan W. Conaway Councilor Robert A. Copeland Councilor Lila M. Gierasch Councilor (The following letter, dated September 7, to Frederick P. Guengerich Councilor ASBMB President Judith Bond, is in response to William J. Lennarz Councilor Peter J. Parker Councilor the Society's support of an American Association William S. Sly Councilor for the Advancement of Science (AAAS) paper, William L. Smith Councilor "Statement and Recommendations on Visa Ex-Officio Members George M. Carman Problems Harming America's Scientific, Economic, Chair, Meetings Committee Cecile Rochette-Egly and Security Interests." An article announcing Dennis R. Voelker Co-chairs, 2005 Program Committee ASBMB's support for the AAAS statement appeared J. Ellis Bell on page 6 in the June issue of ASBMB Today.) Chair, Education and Professional Development Committee Juliette Bell Dear Ms. Bond: applying to U.S. colleges and universi- Chair, Minority Affairs Committee William R. Brinkley In May 2004 you joined with several ties. I am keenly aware that scientific Chair, Public Affairs Advisory Committee of your colleagues in the American sci- and academic exchanges underpin Christopher K. Mathews Chair, Publications Committee entific, academic and engineering U.S. national security as surely as bor- Herbert Tabor communities to express your concerns der protection against overt threats to Editor, JBC about post-September 11 border secu- the U.S., and we have worked relent- Ralph A. Bradshaw Editor, MCP rity requirements and the perceived lessly to ensure that the necessary Edward A. Dennis impact they were having on these security improvements to the visa Editor, JLR communities. We in the Bureau of process do not come at the cost of ASBMB Today Consular Affairs have been working legitimate travelers. We have much is a monthly publication of The American Society for with our colleagues in the Department success to report. Biochemistry and Molecular Biology of Homeland Security and other fed- First, we have coordinated closely Editorial Advisory Board eral agencies to improve the processing with the interagency community to Irwin Fridovich of visa applications for students and ensure that special clearance procedures Richard W. Hanson researchers. that impact the very small percentage of Bettie Sue Masters I will be the first to admit that new student visa applications that require Evan J. Sadler Robert D. Wells security procedures affecting students them are processed as quickly as possi- Comments and scientists initially resulted in ble. Our efforts have had real results. As Please direct any comments or questions lengthy delays. Perhaps more impor- of September 2, 98 percent of all Visa concerning ASBMB Today to: tantly, a perception developed that it Mantis cases are being cleared in less John D. Thompson has become harder to study or con- than 30 days. More than 2,000 ongoing Editor, ASBMB Today duct research in the United States. cases were just cleared. Striving to 9650 Rockville Pike Misunderstandings about U.S. visa enhance the transparency and pre- Bethesda, MD 20814-3996 Phone: 301-634-7145; Fax: 301-634-7126 policies, coupled with inaccurate anec- dictability of the visa application E-mail: [email protected] dotal information and factors unre- process, we have recently begun posting For information on advertising lated to visa processing, fueled visa appointment wait times on the contact FASEB AdNet at 800-433-2732 negative perceptions about study or internet at www.travel.state.gov. All of ext. 7157 or 301-634-7157, or email [email protected]. research in the U.S., which may have our embassies and consulates have been actually discouraged students from instructed to provide expedited visa 2 ASBMBToday NOVEMBER 2004 LETTERS Improvement in Visa Processing appointments to student visa applicants academics and scientists are returning ing misperceptions regarding the visa to ensure that eligible applicants can to the U.S. in increasing numbers over application process and reinforcing our start their programs on time. Addition- last year. Overall, the number of non- message that the United States contin- ally, we continue to work closely with immigrant visa applications we receive ues to be a welcoming nation. I look the Department of Homeland Security is increasing, and we expect student forward to working with you to ensure on issues related to the implementation visas to follow suit for the next aca- that the United States remains the pre- of SEVIS and the Department of Home- demic year. eminent destination for students, aca- land Security on issues related to the It is time to change the tenor of the demics and scientists. implementation of SEVIS and the SEVIS dialogue on this issue and support the fee so that these programs can be as resurgence of students and scientists Sincerely, streamlined and as effective as possible. applying for—and receiving—their Maura Harty Recent media reporting and our own visas in a timely manner. I ask you to Assistant Secretary of State visa statistics indicate that students, join with me in countering the linger- for Consular Affairs Get PowerPoint Presentations From JBC, JLR, MCP, and BAMBED In order to better serve our readers, we, with our partners at HighWire Press, have added a new online feature to The Journal of Biological Chemistry, Journal of Lipid Research, Molecular and Cellular Proteomics, and Biochemistry and Molecular Biology Education websites that allows a reader to download of a figure directly to Power Point. Many readers use figures from JBC papers for teaching and this feature facilitates that process. The figure is automatically loaded into PowerPoint along with the citation information. In order to use the download to PowerPoint feature, open a paper in the Full Text version (HTML), open an article of interest and when finding a figure in the article click on "view larger version." You will see a button, "PowerPoint Slide for Teaching," just click and the rest is automatic. During the first two weeks after activation and before any announcement was made, 3800 figures were downloaded. One satisfied reader wrote: Dear JBC: I just found the links on your site to "PowerPoint slides for teaching." You have my congratulations on an excellent idea. This is a very valuable addition to your journal. NOVEMBER 2004 ASBMBToday 3 Quick, Legible, Lab Labels. ™ LAB PAL Label printer, You're the best. Ⅲ Easy to use Ⅲ Labels withstand extreme lab conditions Ⅲ Affordable- every tech needs one Lab techs and researchers, this PAL is made for you. There is literally nothing else like the LAB PAL™ Label Printer. Its date/time stamp and laboratory specific symbols print labels that stick in the most extreme environments – even liquid nitrogen, freezers and hot water baths. You can use it to label Pre-programmed everything in your lab- vial ID sizes vials, slides, well plates. 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