20․12 DI VISION REVIE W

Where Science and Philanthropy Converge

IN THIS ISSUE: About Us and Our Services / 2 Funding Opportunities Jeffress Trust /8 Hood Foundation /10 Noonan Memorial Research Fund /11 Klarman Family Foundation /12 King Trust /13 Thome Foundation /14 Smith Family Foundation /16 Davis Foundation /17 Lymphatic Research Foundation /18 Scientific Review Committees /19

Gene Discovery in Anorexia Nervosa / 6 [ 2] The Medical Foundation ⁄ a Division of HRiA S A T w m s y e e J I a D g t A h i f p s P t d i a S S F c F U P W 1 a t b D a t n n n h r h h r o c e i c v a r c o n

i e o i a i o e 2 l o l r a u t w r r n n v v

n o m o a h

a e z e e h . . i y i a e r b c c n B

s l u l d 2 m i

n e b

o i o h l i o m c n n n

c

n l c r w

y s r r K M t h o o v s J U y e n

0 o a n c l o l s

y d d e e e

o e e a t i i o o

v i e . m u w a e

a P o n m e s

f c p d W 1 e

t s h c i o n E

p n a

g e t p

r g i . l f m l

n 1 n 2 p n g t

h

M t f y a r 2 o s t u

N t f c . p r i e r d d o H b o r o i r e i i h K . r v

k 9 , s

0 r M ’ c o i e t n n o a , t a

e M

l s e

w u

n t f n e e i s a i e e

o , i i a S c e t D 5

g i y 0 o r

c g n e s g

.

w r

s n l d c

s r t g

r

, r h H o p n c w u a

e h ' r n h 7 s h 1 h r U c s , U .

s t s r s a s

t n e i a e

r . a k a

N o l U r y u s e s n h s

i i , h l e , e o

o D u t

c l g n o g

n t m i d y T

a n i m d

t h s K c

a p n w y e i d

s f u D e , y s o r / l d v a

a p r i r i i A e n o

i o i , t t

g e p s a . b v w e i v c , t r

u s r f m i P M s e

e m l o n c r

u

u g d

e e v m s

e n a

i n . r i M e e l o m i

w s U d r

s h f f m a t

e , v e r o d n d

f e r i c y n . u

e a k M g a

r c t i s s z a s

. e l D P s . e i e r o

, n c

g e s S i d i l

D

s d l i a n

s a c h e A e

c s e i i n i r r .

p

A m n

c N e a e e m M i . t i t a a e

w . n e i e n

t d i d r s v o s n e w

y a t c S , r e c N r n n s n

n v f t

n s c

, e a

a n i i b

w . t a i g b r i a a a . n o h a S

l a n v f i b n w i b t e D d o e o i r a g

s g a o z c s d r

n n n e e i m h r

A c e c s s g u s n r i d a . y , l u m g n a a e n

t c e d o u e r , n

e d d

F i e

e i a w y

o s r t s e

t n a b r C t

s m y u p s s e d a m s g c e s c M y t l

i o

s r

e n , v

n

o v o e i y y a s o

H n S e n s o l e

e e

t d P h

f a r

e e P e p i a b e a

e - d

c n c r . i g e t v c g l

e c n d a c h l

b

P a y l r v t n i l s n d u r a n s d a i o

m i e d e t

r a e o f n

i r o .

e

e w d e o r a u r o h n t i o p i n H i n t c i n o d

- g

n d p v t i

c i a u c n a o d g s h e f n o i a r o e o o

i c a a h c v k e s a

l .

c i

m

s e . a

r n

t r d n

h e r , l n n z r

r i h n D e t

u r s w

i

r

s o a e

a p l l e l l

d t F f t c o a o e a t i c e d d i F a o

r e e d e i R e

i l n r n m s e r l

o n a r . c t r s o i e n t f a l

e a w u t n

r v t r n A r n e

i

t i

e r a g a

e e r l h M i e

n v r m

s o P t h n

d P d e

t

g m s - k w s t i .

m c i

n l s d I h a e d a u m g n g . c C t e s

a

1 t

s h h n h e

t e

t e h e s f s d b r n n d

e e

w o r

u D s

o .

e o 2 a . t m v i y i d a o p o a o e

o n b P d e .

y t

d D

v

r a k d r e i s r $

u e f r o f a s k d . i r r n r b r

t t i i e . m y a c

c o a , n e i o g . c v s f t s h i s o

r 1

s n i t c i

i c

e i h r B c n h a r K c

s w i t

o t m m n V a h t d e j f

8 n c a b w i

i r i a e h a r V e f t u l u a g

n g l t n a o l i

e o

o r

o e t m o g d i l c h r i e c S e i

i , S i m l n

i a i l a

n a g a o n a t

c s m u t m s o b a g c r r t

d e e

h

T c y c s t s r u e a

s g k

o c e e f

d n n r y e i u o a

d p

i a a i r l e

. h h o ,

n n e i i f h s c P l K e

a

i a

s e

d r

t

s d t n i

P c

r v d i r S o o o i i i h r n e

t t a n p

n t s r C n i s n i h d d

e a i e o a

d e u t

n o

n e m o r h d

a l e e p e t o h E

s

h d

e

t e e

e m g f l c

i l r t s g l

e t t i

e t r

s u

s t a s e r n , o h m t

d o n n e s a h h f e i U e E e i y

o o x i t

o t t u r i a o l d u e T a i s n e

i o

n h c t i

e m a e s m t

d c g r o n n F v S i a a v l n r e

i r e u n s

s f y e

s n c e o n i h e r e e u D r j i . i o o t t D c n n e d a n o

r

o

a e a v y t r l

v

i

n d

a i M s h o d u f i i B t t H n 1 n a e

t r e s n e s i e

m s r e e o

s h t n t h n t

y U b a s c n t i t p t o 4 r d

r h

p

e s

a n n . a v h i e u ’ e i P a s d 1

s a v s l h P o s d t i p a n 5 n s g e

a e a a r t

i e

x i d e n

n B

9 .

g o i o n

o v

r t a D a o i

g r , t i

s

f b H N p g

o n y

v t D i 0 h

p B a d a s t i 8 f . t H . u f t e

e m c $ a m a

r

e f

e i S

o n t n H t . . r 0 a u

t 8 o o e

T . a s n m s o d

I n 1 n e h d h r r p m S . i R t e f . 0 b o f n p

e a

n R r s t n

g o

r H a a . k

e

i e a o

. s i e n a g n n

5 i l l o C

M a e t n a s a

g c l - i t

i

o a v

t r t m d i . t A c c t e y h t m a F

r t

v b c

g e n .

a e

t

h i

d r a

b t e t

i P o s i

c a W t ’ i o n o i a o u h e n e n f l s m s c D

a S e h

e

c

i d i i r e B t f R s d r f e o r f

t l d s t

a s e t k

w i a o c

n e c l r o

M s m h i b i l o J y e i B t

a . f t i H c M l a

e i e l o m h r e p

t o r

n a c B u n e n e

r t m i

K H a d r l C r n s e o i F n s o f l h o

n w c h o g

r o e s a

t o e i r l e a d e n R H i a s o r

e

o c R

y

h i i

l

u a o l s t g i o C a n e S a o n g p o

e p t a n i e e m t s l l

e a

l t c o a i l

y h f n r c r u ’ h g a c o c i d p i n S p A o o a

k o s

c a e r c a

r r t m o

M n y n h g u r a A

w c s r l f d v

’ a r i h f y e i D r v h s l i

c

r H a t

r

o y

u

c m a c o l c r

n i w

m p M e i o a

s i d e a F i s

a 2 n r e e l g

t M n a

r e o a h e A . i

h

m t w l t d

r e . r o

f d - a w

0 D r a p

e e e n

a r l l

a

a e e M s l i t a

b l i e u s

i B a t

l p c 1 n y e d a

h

c n a t e l i t c n

I i , e S m c S t e d s s . a h n n s n

e

c c 2 i n i t i e r h i

d h c n o e P i f i c

g s t c n i s

d a d m s t e N e o f

, s c d a

H h n i l e

i o e o

U

i r I t c n g o a

n n

w r e a a n

n i o a

e o t o i .

r

t i e o h g t d n i t c e n n

a l n s

f u g h g s i i n f o h H , n o t y o

e

t

i c t d

r n i t o l f t v

a i s

r a o n

e a . i s o e a

s d e y o s

t r i

m

r s , t e s i r f s v -

, e Our Team Services We Provide Sally E. McNagny, M.D., M.P.H., Vice President, [email protected], 617-279-2251  Creation and Oversight of John P. Kanki, Ph.D., Scientific Director, [email protected], 617-279-2240, ext. 329 Biomedical Research Grant Gay Lockwood, Senior Program Officer, [email protected], 617-279-2240, ext. 702 Programs Jeanne Brown, Program Officer, [email protected], 617-279-2240, ext. 709  Life Sciences Consulting Linda Lam, M.B.A., Program Officer, [email protected], 617-279-2240, ext. 710  Strategic Planning Linley Nykiel-Bub, Grants Associate, [email protected], 617-279-2240, ext. 320  Grant Program Evaluation Our team is supported by a talented array of finance, operations, human resources, design, and information technology professionals. Learn more about our Services on page 4 of this Review.

Raymond Considine From the President of Health Resources in Action I am pleased to share with you our 2012 Medical Foundation Division Review. This year’s Review highlights our clients’ work promoting the careers of newly minted scientists, awarding grants to established investigators, and making major institutional investments to advance medical discoveries. For more than 55 years, HRiA has been at the forefront of efforts to improve health outcomes by supporting medical research and promoting effective policy and environmental change within communities. Since our inception in 1957, important health issues have receded while others have emerged. What hasn’t changed is our commitment to strengthening communities, advancing health equity and accelerating medical discoveries. Uniquely positioned to work with a range of clients and partners, we bring extensive knowledge of public health practice and biomedical research funding to enhance the nation’s health. These capabilities were recognized last year by the Center for Medicare and Medicaid Services when we received one of only 107 Innovations Awards to pioneer new and less costly approaches to asthma control. From our community assessments that enable hospitals and health departments to better meet emerging needs to our development of new approaches to reduce problems such as youth violence, we create solutions to today’s most fundamental health challenges. Health Resources in Action has become a trusted source of knowledge and expertise in the ongoing effort to advance individual and population health. Thank you for your interest in our work and in our mission.

A We invite you to follow our progress at www.hria.org. i R H

f o

n o i s M. Laurie Cammisa, Esq., Chair James Corbett, M.Div., J.D. Stephanie Pollack, Esq. i

Board of Directors v i D Mary Fifield, Vice Chair Chester W. Douglass, D.M.D., Ph.D. Lisa M. Queenin

Health Resources in Action a

Eric Kramer, Ph.D., J.D., Treasurer Timothy Edgar, Ph.D. Joan Quinlan ⁄ n o i Nelson Valverde, Assistant Treasurer Lori Fresina Jennifer K. Santos, Esq. t a d

Harriet G. Tolpin, Ph.D., Secretary Walter Guralnick, D.M.D. Thaleia Tsongas Schlesinger n u o F

Raymond Considine, President Peter Hiam, Esq. Harry P. Selker, M.D., M.S.P.H. l a c Carole E. Allen, M.D. LeRoi S. Hicks, M.D., M.P.H. Miles F. Shore, M.D. i d e M

Philip Caper, M.D. Allen B. Kachalia, M.D., J.D. Nebulla Stephen e h T [3] Life Sciences Consulting and Strategic Planning Finding the Best Minds in Science

The Medical Foundation division’s Life Sciences Consulting Exploring Philanthropy’s Role and Impact in Supporting provides foundations, bank trust departments and individuals Biomedical Research with the powerful combination of in-depth knowledge spanning Philanthropy has a critical role to play in supporting research laboratory science to clinical research, a wealth of data sources discovery. When a client is considering whether to fund scientific and commitment to finding the best minds in science. investigations, we offer strategic planning to help guide the process. Based upon specific interests, time horizon and funds Imagine you are a funder who wishes to support cutting-edge available, we lay out a range of approaches that maximize the research relevant to a particular disease and you need help impact of their philanthropic support for biomedical research. in identifying leaders in the field, learning about the latest breakthroughs and judging what research projects merit sup - Unlike the National Institutes of Health which must answer to port. To assist such clients, we contact thought leaders from Congress, philanthropists are free to seek out investigators more a vast network of research colleagues representing academic likely to innovate, experiment and take risks. Nongovernmental institutions, the nonprofit funding sector, and pharmaceutical funders are able to move quickly to fill identified gaps in support and biotechnology companies. We also scan the N.I.H. grants and can choose their own distinctive niche. We also work with database, review the scientific literature and evaluate abstracts our clients to define goals at the outset of any funding program of preliminary research findings presented at recent scientific so that a clear evaluation plan is in place to measure the degree meetings. to which program objectives are achieved.

The Avis and Clifford Barrus Medical Research Foundation wanted to support innovative research in drug development that could lead to effective therapies for individuals suffering from severe, refractory depression. They retained us to search across the U.S. scientific research community and recommend several accomplished investigators for their consideration. Following review of invited applications, the Barrus Foundation Trustees elected to award $300,000 to Carrie K. Jones, Ph.D., Director of In Vitro and Translational Pharmacology at the Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center. Dr. Jones is developing a new compound that may offer rapid alleviation of depression by blocking glutamate receptors, a mode of action completely different from that of antidepressants currently being prescribed. The Harold S. Geneen Charitable Trust enlisted our consulting services to identify promising junior faculty in cardiovascular research. Among those we recommended for consideration, the Geneen Trustees selected Margaret Doyle, Ph.D., University of Vermont, who is analyzing plasma biomarkers to develop a specialized blood test that may improve risk predic - tion of coronary artery disease. They are also supporting Bernhard Kuhn, Ph.D., Boston Children’s Hospital, whose research may elucidate the underlying mechanisms that control heart muscle regeneration. C c d m P e i h o u v l o u i s l s s t r c o t i

l e o a m e s n r

i e y

s c (

h y r o i n o o e f

g w l B r l r e o i e a n d w r p g

n

h a

n h a

n u o a

d h c f r

d e l c h e

a e u K u r l m t u s l

) h a m n . n n

u u H ,

c s

h e P l c e e a h l a i r e .

t r D i

t n c m

.

e b u l l l s u

c i e n l e .

p s o f a m t s t m I s a i p b R I ( T a p W C n m f I d u h h e c e H n t l c o m u r i r e o s l h i c r o e o r n o a e o e e c g

o

a u n h e u b

R v l 2 t j n e 5 s t e

m v d r a e g r w r n o o h l F N e e o o 0 e t

l 2 c e n t i i e e e d i A M e t p r r a s c i d D

e u

1

s i i d f

o

s s t e r r H l d

r l m z f d e y y a i ) . 2 h y e f c a a A

w i

e n e

a ,

a s

c

i F b c s

k h h , o t c a v R c

e d c t g t a i h

e . i

f e

y H C c n i

f i

t g o

m a n e i a i r n F o A n

H o l C i i a e A

c h

o l r p a r x m

H h r a R a t

1 n a s

- e n p a l b i r t r o t R

s t p t r l s l n a i h m 5 i l s h s m e i r l

p e c

R v

A n e e h i y a i

e i r i i t , g s

e F e r r A a r n o e , n d

n e 0 a r t e

e n

n

t e

A n u o i i H t s K r r

r o o i r 0 a c a t

m s e h e

g i . f c t

d n i u .

n o r s e

o r u f 0 W i a

h r s i o h R t e m c e J

r a

g f a n b

t p d s

n o t d

a n n m b a h o

t

t n r a u h d e o n e

a d A l i p i e d i l e o s r e t n

i v l e n o r s r t e a

r i i m t a o g v s i i s n g s o s

e s v i s k s t n

n

n e e n . i i t t c w z

, c

S i B . e

s

h l

i t b a g r g o a E o a d P e

c

o

e n o e c

s r

o f l e c s e t , h d x n

t

e x v

m

c f i g

i

t o

r . f a o e c n

o t p a t

e t e h D o r F

a a

o r r d o i n n t a r w o d r c . a n h l n c

d a D a l

g i i y n p t c n u g

r i s c c v n

r i . e l e

g A

r a o s f d t t e k o a i i i i c D o o t o h i

t n b s a n i

h v m

D o a i r n j n r r

u l a d r o g d r e e t e

t e l t . n g i e p t i l t

l h

i n c r

z s s e i a h w S u D

d a v a e t n t e a

t i i n c i s e a i m r i

t n a t t

i g i n

t s o f a s l i

F i s a t r r s r i

n l o s

H o

h l g

v c e u y p o t o g y m o o s s

n o h e u

c

n p r t r s o n e t f M v l o t m e s

i i a e h

p a y

d s o m s s f

a n r n u m c

u l f

h e o

o t

r

c b t r a o p t d i a

i , a n h e r e N

v s b a u b n e n e r n k

K t d

e d n

e o t o t e e l t d R d i p a w l

t o i e

x a n v d r u y

L a i n g g

r

r

t m s i e D g e t

o t h b e e n g a

r d i b b a a

s e t a c f c

e t a y v b e e s o r m y A i n n t h t e , t c t

t u a a

i a r

i u e a

t m V e i h i e m o f r s g t n o m e

l o r c e a

h n l a m g i n

i e n f o p o A h e

s c b u e d o a z s s m t t t n o m r l e

e

h

l h k e n d s i A a e e b N g f m r

, t e r i i l a

m d i

P b

t

e p n l o

h c t h t t e , o l I c i e b

h t r

o

i v g

i n

i H M c w o e f a P p r g n e a e

t g d u

n s m a t h u i r n r i r

o e i m h

h . s o

r n c a d n l b o S

e o t r i r m i n e e $ g d r e g m . n l g p e f f e .

c i P a 1 d

r

n

a h n p c

u r b . t a a t e .

t n o t H a i h u t t 5 n d p m

h i a

o n

l v t i o o e b

y d h i f i e z i . n t i b c u

o m

f l

l a a n

r i m i t H i

a

i i s l n e m n t l h c

( n T g l a c t

e i l s F d s

f i a n o e

r i i c s d p o u t h

h o e t D i p

a t n l h o e i n

l k n n u e n h e n l c a e s r f A t e g

a d d r t a

a . i o

m h M

a s i o i m y e T

l l ) i e f n u t

o n

n ,

a p i h e

R c s r h v e i c g s e v d H c

g e i s n

. e i

d e

e h c h s

t s T e

n c t t s u c a o R

r e o i

e s o t f d f c

l i o h y e a e

i u r o a d t a m h a g A o r e r g s e l a s p n r

l l c t

a a r e

a t

a m c

a n

m d h H c t F h r f n l e a b b o p e

h i

c o s r

a i o t n u h a a e c r

t e z

r o t u s A s a n r s a g n e o a e i t e

a b o n l

s

d t r i

s s l t

t s i t l e l u s n d h w

i o i a y i

o t n s a p a

r r

n h a i n n g t y a a p l s b i e l n c t i ,

o o .

n

h t o d e d o n r i e

u

t n

, n t g

, [ 5] The Medical Foundation ⁄ a Division of HRiA Gene Discovery in Anorexia Nervosa

Anorexia nervosa (AN) is not a choice but rather a serious they recommended that KFF support the collection of a large biologically based mental illness that adversely affects the lives sample for genetic analysis. The value of such an endeavor goes of millions of women and men every year. Although adolescent beyond understanding eating disorders. Since individuals with and young adult women are most commonly afflicted, AN can AN frequently have symptoms of other disorders such as anxiety, strike at any age and does not discriminate on the basis of sex, depression, obsessions, and compulsions, a large collection of race, ethnicity or socioeconomic status. With the highest DNA samples with clinical information would also enable valuable mortality rate of any psychiatric illness and with no effective cross-disorder genetic comparisons with other psychiatric disor - medications, there is an urgent need to understand the ders. To maximize the scientific impact, KFF was advised to biological causes and to develop new treatments. require that the samples, clinical information, and genetic analyses be made widely accessible to the international The Klarman Family Foundation (KFF) recognizes the critical scientific community. importance of supporting research that may translate into new treatments for eating disorders. Since 2008, the Foundation's The establishment of the Anorexia Nervosa Genetics Grants Program in Eating Disorders Research (highlighted on Initiative (ANGI) page 12) has funded outstanding scientists who are exploring KFF is pleased to announce the launch of the Anorexia Nervosa the neurobiological basis of eating disorders. Through the years, Genetics Initiative (ANGI). Through a competitive, peer-review some applicants proposed to study the genetics of AN since process, KFF selected Cynthia Bulik, Ph.D. and her research team there is growing evidence that AN is heritable. The KFF Scien - in the United States, Sweden, Australia, and Denmark to collect tific Review Committee cautioned that successful genetic clinical information and blood samples from over 8,000 girls and research requires large numbers of DNA samples and that women with AN as well as individuals without an eating disorder no such resource existed in the world. to serve as controls. The ANGI team will analyze the DNA by In March, 2012 KFF convened a meeting of leading human using genome-wide association (GWA), an approach that involves geneticists. The experts emphasized that genetic exploration finding variations across complete sets of DNA that are associated of AN lags far behind that of other psychiatric disorders and with a particular disease, in this case, AN. These variations may not themselves directly cause the disease, and thus the research

KFF Initiative Oversight Committee

Joel Hirschhorn, M.D., Ph.D., Chair Jordan Smoller, M.D., Sc.D. Mark Daly, Ph.D. Thomas Lehner, Ph.D. Sally McNagny, M.D., M.P.H., Scientific Research Officer

A i R H

f o

n o i s i v i D

a

⁄ n o i t a d n u o F

l a c i d e M

e h T [6] team will take additional steps, such as sequencing DNA base ANGI Lead Investigators pairs near the variations to identify what we expect to be many United States: University of North Carolina at Chapel Hill genetic changes involved in AN. Recruitment will begin early in 2013 and genetic analyses will be completed in 2017. Cynthia Bulik, Ph.D., Principal Investigator Patrick Sullivan, M.D., FRANZCP KFF established an Initiative Oversight Committee that is responsible for scientific monitoring. Study participants will Fred Wright, Ph.D. provide broad consent so that their DNA and clinical informa - Sweden: Karolinska Institutet tion can be used in a range of research studies exploring gene Mikael Landén, M.D., Ph.D. discovery in AN and other conditions. The Initiative Oversight Andreas Birgegård, Ph.D. Committee will work with the ANGI team to establish a Resource Sharing Plan so that samples along with genetic Claes Norring, Ph.D. and clinical data are readily available for research purposes Paul Lichtenstein, Ph.D. to qualified investigators. Australia: Queensland Institute of Medical Research ANGI was created to help solve the mystery of how genes Nicholas Martin, Ph.D. and the environment act and interact to cause AN in a way Grant Montgomery, Ph.D. that will aid future scientists in developing targeted treatments. Tracey Wade, Ph.D. KFF hopes that its investment will inspire others to support Denmark: Aarhus University research in this and in other biologically based psychiatric illnesses. The Medical Foundation division has been retained Preben Bo Mortensen, M.D., Ph.D. by KFF to manage the Initiative. To learn more, contact Sally E. McNagny, M.D., M.P.H., the Initiative's Scientific Research Officer at [email protected].

Cynthia Bulik, Ph.D., Principal Investigator

A i R H

f o

n o i s i v i D

a

⁄ n o i t a d n u o F

l a c i d e M

e h T [7] Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust Reshaping Research Funding Opportunities in Virginia

The Medical Foundation division was recently retained by public work in geosciences, engineering and other industries U.S. Trust, Bank of America Private Wealth Management to and businesses are actively seeking researchers and workers recommend a new scientific focus and review process for the with such analytic skills and knowledge. Developing such a grants program of the Thomas F. and Kate Miller Jeffress ‘culture of computational science’ in the state has the Memorial Trust. The new Jeffress Trust Program was to remain potential to reap both scientific and economic benefits. faithful to its founding mission, to “benefit the people of Virginia After careful consideration, U.S. Trust, Bank of America, in, and devoted to, research in chemical, medical or other Trustee of the Jeffress Trust, approved our recommendations scientific fields,” but to be reshaped to incorporate application and the new Jeffress Trust Awards Program in Interdisciplinary review by an objective Scientific Review Committee and to Research was announced. The Program funds research that utilize efficient electronic grant submission and processing. incorporates computational and quantitative strategies within The real challenge for this restructuring was the enormous traditional scientific disciplines. Awarded Virginia scientists scientific scope of the Jeffress Trust mission that spanned will use the power of mathematical modeling and statistical such diverse fields as geology, chemistry, biology, astronomy analyses to answer pressing research questions across all and mathematics. Establishing an objective, but not unwieldy, fields, ranging from geosciences to human genetics. Faculty in committee review of such a wide range of research proposals Astronomy can work with computational scientists to develop would be a daunting task. The Medical Foundation division new approaches to interpret the terabytes of information collected interviewed leading scientists in Virginia and reviewed NIH and each night from observatories. Geologists will have the capacity to NSF support in the state to identify funding gaps. Based upon develop new algorithms to analyze global weather and seismic our findings, we developed a funding concept that would cross data to improve prediction and disaster preparedness. Physicians scientific disciplines, include both large and small universities working in cancer research will use thousands of stored images and promote a future of cutting-edge research for Virginia. from tumor biopsies to develop better pattern recognition models Rather than limiting the new Program’s scientific scope, we for more accurate diagnoses. Plant geneticists will collaborate recommended focusing on a single scientific strategy that with computational scientists to discover which genes make crops would cross research fields while keeping grant review and more pathogen-resistant. Program oversight manageable. The Jeffress Trust Awards Program in Interdisciplinary Research This unifying strategy recognizes recent revolutionary will provide up to ten one year, $100,000 awards each year to advances in computational sciences, information technologies, faculty and their students. The Awards support pilot studies that mathematics and quantitative analytics that have contributed to break through disciplinary silos to encourage innovative cross- major advances across all scientific fields. Computational science disciplinary collaborations and expand creative, high impact (not computer science) uses mathematical models and simula - research that can catalyze future scientific research in Virginia. tions to understand complex systems and processes in the In October, John Kanki, Ph.D., The Medical Foundation division’s natural world (e.g. predicting protein folding or climate change), Scientific Director and Jeanne Brown, Program Officer, launched and provides powerful new ways in which huge amounts of data the inaugural 2013 Jeffress Trust Awards Program. can be manipulated and analyzed to gain scientific insight (e.g. bioinformatics). In Virginia, significant numbers of private and Learn more at www.tmfgrants.org/Jeffress.

A i R H

f o

n o i s i v i D

a

⁄ n o i t a d n u o F

l a c i d e M

e h T [8] “Computational Science is now well recognized by the scientific community as a critical enabling discipline underpinning modern research and development in all fields of science, engineering, and medicine. Many fields of science, such as climate and atmospheric sciences, elementary particle physics, and chemistry, have been transformed by computational modeling and simulation. The prediction of material properties and self assembly, emergent behavior in complex systems, and the formation and interaction of stars and galaxies have likewise benefitted in critical ways from the development and application of mathematical models and algorithms, software, and ever-increasing computer speeds.” Computational Science, Mathematical and Physical Sciences Advisory Committee (MPSAC)

A i R H

f o

n o i s i v i D

a

⁄

n o i t a d n u o F

l a c i d e M

e h T [9] Charles H. Hood Harvey P. Hood II Charles H. Hood II John O. Parker Hood Foundation Child Health 2012 Award Recipients Research Awards Program

Irina Bezsonova, M.Sc., Ph.D. A Program of the Charles H. Hood Foundation University of Connecticut Health Center The Role of USP7 in Pediatric Neuroblastoma The history of the Charles H. Hood Foundation demonstrates a century-long tradition of commitment to community and child Elisa Boscolo, Ph.D. Boston Children’s Hospital health. In the late 1800’s, Charles H. Hood was a pioneer in the NOTCH Signaling during Pathological Blood Vessel Formation and Maturation dairy industry. By introducing pasteurization, his company signifi - cantly improved the lives of thousands of New England children. Jonathan Comer, Ph.D. Boston University His interest in science and the health of New England families A Controlled Trial of Telemethods to Expand the Availability of Parent-Child inspired his son, Harvey P. Hood II, to incorporate the Charles H. Interaction Therapy for Disruptive Preschoolers Hood Foundation in 1942 with the mission to improve the health Roger Edwards, Sc.D. and quality of life for children in New England. His son, Charles H. Northeastern University Hood II, assumed the presidency of the Foundation in 1974 and Use of a Computer Agent to Promote and Support Breastfeeding became President Emeritus in 2009. Under the present leadership Arvin Garg, M.D., M.P.H. of John O. Parker, the Hood Foundation will continue the family Boston Medical Center tradition of supporting outstanding biomedical research to improve Do Basic Unmet Material Needs and Social Safety Nets Influence Child the lives of children. Maltreatment Risk? A Nested Case-Control Study The Charles H. Hood Foundation has demonstrated that M. Kyle Hadden, Ph.D. University of Connecticut supporting promising investigators at the beginning of their careers Vitamin D3 Analogues as Hedgehog Pathway Inhibitors assists researchers in securing long-term funding from private and government sources. Ultimately, this kind of leverage funding helps Janghoo Lim, Ph.D. Yale University to build the biomedical research workforce that will contribute to Molecular Pathogenesis Studies of Childhood Neurological Disorders; Rett improving the health and well-being of children now and in the and Angelman Syndromes future. Since 1942, the Child Health Research Awards Program Katie McLaughlin, Ph.D. has funded 609 investigators totaling more than $56,675,000. Boston Children’s Hospital Neurobiological Mechanisms Linking Adverse Childhood Experiences to In October 2012, the Foundation celebrated 70 years of Adolescent Mental Disorders grantmaking by hosting a scientific poster session and dinner. Award Recipients, Committee members and Institutional leaders Valerie Schumacher, Ph.D. Boston Children’s Hospital attended the event which also included three talks from distin - A Role for Staufen 2-Containing RNA Granules in Chronic Kidney Disease guished former Awardees. The event honored both the research

Zhu Wang, Ph.D. community and the Foundation’s trustees who have dedicated Connecticut Children’s Medical Center themselves to the advancement and improvement of pediatric care. Statistical Methods for Postoperative Morbidity after Cardiac Surgery in Children

Blood vessels in infantile hemangioma, Program Officer Geographic Eligibility Award a tumor that occurs in 5-10% of infants Gay Lockwood New England Two-year awards in the of European descent. The tumor is [email protected] amount of $150,000 comprised of a mass of disorganized blood Research Focus Clinical, basic science, vessels where abnormal pericytes Program Eligibility public health, health (green cells wrapped around the vessels) Investigators within five years of their first faculty services, and epidemiol - fail to regulate blood vessel growth. appointment ogy research relevant to Courtesy of Elisa Boscolo, Ph.D. child health

www.tmfgrants.org/Hood w f B J P T A D i I P J o t w t T l F N o I n e h I g f i s o w a f i r c L h p n w n e n n u o h n n a a e e B r r r t f n r f p e e h h r e i o r

g v h i o o w u f o a

s m t

m t n P e

t o f n a o r l a e t r i e i T e a e e h p w a 2 e l g g e e l o n t o o a . m

d o e

u e

d r n g s t n o r r u c r n r w d n s r i i

a a r 0 m n o s n

a a t l y l c b v f D N p r n b i v i k o i r p S e c r i i f z n p x e n s p a n e m m g g 1 e f e

e a y e t t i e r

a a g @ i o i e s r t a r p i o d s r c B c

. g r M o a s

2 n s e s n k o n o i o t r n o c r O E t

o e a p r b i

o a p e s

e h o r

f , . l f o T e t , v n

U l t l d f t

s h i o v i

s n m . y i r

i

e o n F r f t n i

r l i s p r w o U s h g

n i

s w i t o o

c t e e o a u h s

a n c s N e

r s h

i a u o i

u

l i a t a e n n g f t i

n s d d n b w h s a . e v n s c o . s o s e i

o t n o e n o l l o i v

c r s , t s i

i h h o p

o s t t w e

l r f n r 1 n n

h

h a

a b C s i d i e o y i o g r a g P i y S o

e o

F t a m

k o n t

5 g d g

y e p o h M r / . y n c

o r i t n m

n N i c h r u

A

h s n f c n c

h 3

s u o f p a i T l c a p i a a s o p i e

a i M l . u n g a c e e

l e l e t

a a n v o D r h n o h r o u t

e

a t

y a m o n d s

o

. n h o n o e y n b y f e g e

r e e i

d s

. s w l

a a n i r

F v e

n

S i t i

e d o

v r n r c x

p i u l o s o i e b i w n c c e e b i a N s n m d f r w i e c r a

e e v

. e d l

i e o h w a . h

c r c m i

a i c

o s - h e m n n o

t l

l

b d A p e e m g t l i o i I o i e u c y r

v N i , G R C o p c G o

l t o i m t n y t R e o n s r d r

s v c y s g i h a s o s r h r p h e e r l i o r l n n

o o

o i

o

m s

e

e

e o

r

n o n s i t e t U g d e o s h p

c o l l T a a f v t u w a j a h e i o

a e d

g

a a i e n o e h v v i n u l r a c . r o e e o S o n

t a z t r n r y n p n c e m t S i

r e i e c l u a d i a a e e a b i p t r f r

r e r l r e t t

d n o t

a r c l o h p

s n o t .

r

y u a t o s o t u i

M

d w p o p w d M h

r n r

i

v r

h h B

n

w n ,

f

t T u t b r e d e o a a w e h c u e r

i o o

a e

e e e i i

s o

F c

N e r s c e c t a e t s f c o n o e s y C t i v e M t l r t f u - e s o

u h e t

i

e

N m r

h - e a n d h E t e q

s b c t f d e i d t c l a a a o t

v h s t e d

n

-

o p l

m a h e l o o a i i e d u i t a r a l u a t e

i a

d t m

n o l s c d i i o g c a n h f

d p s d , r r m o n f . r s e p n u h

i a s o d m i r h

i s

p c o

c t p n o o e t b

e l n A r B m i t i d s t b a d l t a r

a

a m i r a h l o h i h e m i a t v i

r s m

e

i e b l a t

o i b s v y

c y s o o i l n d r n a y a i p

b e , a p

i . t

, . o n t m i

a i l

e a t h y m v R

o i o

i g t t i a

t . b e i L e , t o n t o k a r e i n l F h

n s e a i a n r h n v l i

r e e e i K l d

s f

g

o t e e a n s e d r u e t s l e s

o s s R y e o c s t l T

a n t n l p ,

l o d e

d -

n o u t t 2

i f e

e r

o s o N d e t t f c h r o

o t c e n n

r s f d h e e e p 0 d a a A f h m

t a s

e l f e s h

c o a a g o i s b

s

, u r e t p

1 m e e O A a M d n m e f r a

i t y i o c y a l e m

t

m o r e o w m B r a o

r a n 9 i

i o i s e

e n h i i s s s m u n c a d r t n o n a e D n r p r r . o 0 l a e a t o r

p a

e t e a p

c r m

- e e n u e

o f c e i y F i U t n n d y p e

m r c p a n c n d s l o h y n s c r

s s v e h

e u m k d r

i f c c D m

r a r r

s

t i g

a h t . a e d i o o

e i g p R o b e t F

n n r

e e i e o r l

a l l o e r i S n e v d i a r

a n P j a s r

f y l u d d s o n d a e i

e

d n e a f e r o s t h g r r e o $ , g

r n w o

r n

s

s i t

c e l

L x p

c i r t t A o

t l 8 i e a s b y r G r

a e t , v

o o e t h d o t p n a o a a p r 0 h

d n p

y

r m r

y a a c o P n t

c a w e

d t u c e ,

l s r

l e e

r r

U i w 0 l o t r w o i k c e s h e

p r c h , p o a h r e e r c i c

r a 0 w

l i l s h e a a . l l h i i i

r j n r . P i d

l e e

a h 0 n i

S l t e ( n

D o W o s i v l i

s d i O h i s e n n t c l f

A e

t h l o

c l . p t e g j r i

o d L h d F . h i

h

e x o a

v r c g e e f

S . t t

T s d

e r e r s

d e D i s p r u w o e c n , R t e i s a w s r o r

D e c n e

i a m s

e o o e l t l t u n s s

N l . p i t n n o o s l i a n a s e o t l

) h m f a d s i f

e s d l h w o e . . e p

r

k i m b . r

e

f e

b r t c t c f

e A u w

d n c , E s o o

i r s o r l t M h s a

a h i l t

i a a s o i h i .

d

l l c M

n s i m u h t a n r

a t i

i l t a n i e h y m a t n e l h e l o c r , c h l s g e l g y a v i d

d

e .

i e n e

o

h t e P e

l t D h n

e e

t

p f c r y r e u d a h h

f a s e e l n d o

n a x

e h o e i o o

h . a n w . l m i g b e u x r l F d ,

c t t h s n

u e r w . r l t

i i i i h p e

r o D m h

l i a n b e e u n M o d a

E t p d t e o c - m o e w w

e r b p i n

r c . g n i s a i a n u n a r e 1 n

. o r o t r i t e i h t e

w P c h r s c t n t l g n b e a i

m p a d 9 a c i i l

o n n . o a

e t s t y h i -

t n g e n d H o l r , 4

i l n t

m

o m

e

e

e l o o t

r a w p m w d s e

t 7 F . a

t n , g t s s j h f v e

m h e

n i h a e

e i l

, l t g e t t e e i b

l u o n t e

u c c e o h g r h f

o u S

a y - e t h t t d d d a e

s

n c c r

i t

y s i l

n h . r o y

D d e r .

O i I f A P I D E F B K B L 2 H L T B G B E R n n r m i e m n a o a r h o a o o u a a r e e 0 n

t a i t Y m s t s e s e m p r h r e t v d d a i h h n 1 i e v t t t l o l r

e s a a s

u o o o y o e

a i d V f n S u 2 m l O l c n a a P

n n n c s y r o r e I t F t n t i r y c d P c - i

i r i p i

n e s s n N C U M C r

A e s g S e o

e

D m l m

e i M g I h s n

h i i

f n

p a w e n U n e

C n f

S

c i o i D b e i o E e v e d D l t v m l g

n h o h a d n d e i e n C r d r c a i e g , i i c

i i c o r d e r r s r

v i t t r l G h s r a e C v P c g d i

r a o l , r p d e s a c a y u i

t e n s r a , h r l o l l i r P i a l

o

n a d

t e o , m n '

s l I . S R g t C y

s r h W l

n D s d o r n n i P t i l S n c

e e t . t

i p e , t .

H

o y h D i e D

c . e A i E n n w e

t P D c n o . l . A h i r t i v s l d

D v i s h . e - v s i w : o t a

s B u e

. p o h e . p r i U o s l n D i

l r u n t

i e i t i B l d h A t

. s s e h

a i t a T n i t e i

e u o t i n o n l a C m i g r h t o o n n g t e i

a s d n s e f

c r o o V m v e

l e y i o r n i b o d

f

U A S A r r

D e a a a p d u s o e l

l e i

o

H t

n v T P i S c l s e e g u h a e t m l s r

m e l o l a u s f c

r - p

y D m a e a R R m

n n p i a e

o a - t D y n e f b g s M l

n d i e

f n o s w o t a

c t o o

S r i c i P t c s

r t i t A h h d o i r a

s T o n i

n e t n

a h k h t r

x e h n t s e w u i o e

r m a

o t y y u b [

s g 1 h 1 The Medical Foundation ⁄ a Division of HRiA ] Klarman Family Foundation Grants Program in Eating Disorders Research A Program of The Klarman Family Foundation

An adult male drosophila fly brain stained to reveal The Klarman Family Foundation is interested in providing neurons (green) expressing the Pyrokinin-1 receptor. strategic investment in translational research that will accelerate These neurons have been implicated in regulating hunger in the fly. Courtesy of Leslie Vosshall, Ph.D.; progress in developing effective treatments for anorexia nervosa, Photo by Nilay Yapici, Ph.D. bulimia nervosa and binge eating disorder. The Program’s short- term goal is to support exceptional science and to encourage outstanding investigators from related disciplines to direct their 2012 Award Recipients TWO YEAR AWARD attention to eating disorders research. The long-term goal is to Cynthia Bulik, Ph.D. improve the lives of patients suffering from these conditions. ONE YEAR PILOT STUDY University of North Carolina at Chapel Hill Determining the Role of Uncommon Since 2008, thirty-nine projects, totaling $11,625,836 in Kenneth Carr, Ph.D. Exon Variation in Anorexia Nervosa research funding, have been supported. Twenty-six separate NYU School of Medicine Effects of Food Restriction on Sucrose- institutions throughout the United States and Canada are Kathryn Cunningham, Ph.D. Induced AMPA Receptor Trafficking and University of Texas Medical Branch represented. Behavior Fine-Tuning the 5-HT2AR:5-HT2CR Rheostat for Therapeutics in Binge In April 2012, Award recipients gathered in Boston for Andres Lozano, M.D., Ph.D. Eating Disorder the Foundation’s annual Scientific Meeting and presented University Health Network (Toronto) Deep Brain Stimulation for the Treatment updates on their funded research to the Trustees and the Bingshan Li, Ph.D. of Refractory Anorexia Nervosa: Pilot Trial Vanderbilt University Medical Center Scientific Review Committee. Joel Elmquist, D.V.M., Ph.D., Mapping and Functional Characteriza- Professor and Director, Division of Hypothalamic Research at Jacqueline McGinty, Ph.D. tion of Genetic Variants Associated Medical University of South Carolina with Anorexia Nervosa UT Southwestern Medical Center and Timothy Moran, Ph.D., Prefrontal Cortical BDNF and High Fat Paul R. McHugh Professor and Vice Chair, Department of Food Seeking Marina Picciotto, Ph.D. Psychiatry and Behavioral Science at Johns Hopkins University Yale University School of Medicine served as Committee Co-Chairs. The 2013 Acetylcholine: A Novel Regulator of Circuits Involved in Food Intake and Committee will be chaired by Jeffrey Friedman, M.D., Ph.D., Eating Disorders the Marilyn M. Simpson Professor and Howard Hughes Medical Leslie Vosshall, Ph.D. Investigator in the Department of Molecular Genetics at The The Rockefeller University Rockefeller University. G Protein-Coupled Receptors Regulating the Sensation of Hunger and Satiety

Yong Xu, M.D., Ph.D. Baylor College of Medicine A Central Estrogen-5-HT Circuit

Regulates Binge Eating A i R H

f o

n o i s

i Program Officer Geographic Eligibility Award v i

D Gay Lockwood United States, Canada Two-year awards

a

⁄ [email protected] and Israel in the amount n

o of $400,000; i t

a Program Eligibility Research Focus One-year pilot d n

u Faculty at nonprofit Research with direct studies up to o F

academic, medical relevance to the basic $150,000 l a

c or research institutions biology of eating i d

e disorders M

e h T [12 ] Beth and Seth Klarman www.tmfgrants.org/Klarman “ p a s ( f o y P w a S t p t I t s r t d t t T T a c s T C p i w F M P L P T A B C L s “ p r f t 2 e c e i r n r m n e h h n h h e h o e r i L 0 w c o r r u i u l a p n o o

c r i h h h r h A n h a a s . s n i l o o l s s r

1 e a P e e

e e e c b o o D i r t y o u w o d h f n t e d t p i d n r r 2 m g g i u e e N t s a h 0 m e v

f e h

s i i r c s c v d . a w u p f a . r u i r r e p t

a t C m C d b l

o 0 s r e a n t l K a

F a a

n

r c i e i i r o a @ c e e t l C a m

i l t e t s

y d r c e o c c L , i o n g g e a h i s m m l c l 1 h e s n h

o f ) c e e t c i

b

s l h i o u h a f e h

h e u

O a g

i n e n t l r n T b v s e o d g a e s

t p

2 a o r o f e v s n s e i i m l e s u a r E O

b w s o a a t a t F e i d g r p

w g

g

a r i i h r a

e r

f y , s s r i

P l a , t t a l f e m c H t r i J t r c e

i o r o

s

i s d w

l l a R )

o f

s

s

s o a e o s

e n . g e A

y t o

i h i

t l e a t e t a o b

u

o r d

o f n D c t e h

t t n c

w . i w t i l h i

s e

r

e p . o s

p h M s c a i s s r m l v

b l h

e e i h y u t D M f p n o s f s o s u t

e t a g t h H o p . r

v p s s o f u p i e e r i

m n y e a

r o n o m A , i

n

l . o e p o

h r n r a

o E s s o T i a g i

o

A p t r t e r r l s

o i n d e n v r t . p

p h i

h h u s l c e d g h . u n R

p i

K p e y t n h h a

n W o

a d r a m

. n o o w o i d i I o e / c o A i

e a g e r K e n

t m c I i n n K a

s l i e l w e t e i e r i m i e o d f s K C i a f n i

y i t .

r n s h c r i

o i

t

e s t g n

i H

v n i

i

x C n p r m

a

s

d s p t n t a A

t g . i e g

B t t A a r

s e i

n c F

r

h n i o e g i c c t h n g t l o n o e

t n e i c a v

g

, o

i l

a e l h o u s i o t o f m f n e g T u

n

e

r v t d e e i m d i n a o

n K

i

N F n s e p e M m n e o

f e s u r T

l n s P

l g

d s e l m m i o h T m , p s i u o a i t b . d h t

w s o

c

m r n

n o

n h n A . h s e i i n p a r l u t t i e t u l s s y m

i r e

m r h g i s a e v d a u i h u a n

n . S r

s s i g o e e i

G M R B a r g t c n i s n T i

n , t S e t

U e e k g r

r a o s e u e p

n g e e s w a l

o p t e d t s t t a i f a y c r

d w a s l i l E u v i e i h t e . t c g t u o s d .

t t a s

p

f r u n t v e r

m e h

s t i y S K h o e i d a c o e g g u D r i r e

i y d H p t o e w o e n s a e i c v o

e r

h s g a v

e r r . t

a r t a f

t

i r

a e W r n l

v i d h r e s a s

w e y d e a t n i r

r a h i o n i . d l

c s e u r c T o o n T

n . c c h

e

p c e t

t a

n , d r

u

c a h e n s f g a b h s h C

e r A . g a

h g i h a j n a

l n i e c

d u i c a

t u n t e T t C

e n d e e u e r

s

t v i T h e

l

R v a n

e s

e F r T e c h

o o n m p c f s n s c y n s

o h

d d o

h i u m o a t a i l m

s

D t d r c r s e b t a o o e c l r c m n c e r d t E R f , h c e t e u r i , c u n t e

s a t e

e l

b s n s

v e l

e r a l

e g t u a f

i

s p t

u r i D i e m a B

e s , s P i s g e m n n K l d a u i i g n s h H

v s

s d e

b t r s s e l

b c a c t A s a

i i i

e e w

i t t

i r n t i f n c e B

b a

m i o

t h

c n l y l m i a b r c e o l o e n o t N i p h d d n i ( t i e

i y a n d

i n

a u n o s g o a l t r

8 e t a n k g C l j n o e s ,

i e b i E i P l e r s m s e l o h h o

i d

m t y n c l o

f

i r s i

r n 0 T s e y

m

h e

r e o n b r g n a l o a

c e a r a a m i c g r A d i o

s m g 7 w c y t p l s b o a s e d d u o f n g t t h d h m n , y i

e N

m h e

.

l o )

s r t m l s e o y s e H A a d W i

o r

a e y d , e i

a l n E t n s t s D R i . a e

, r w n

r e r r m

f

n t v

t c

r a d x a

r u h

t i a F

t A g h

i g c T s h a h v o c e c e o a h t o h h c

L h

e e

a i a b p r e o

i 1 y f d n n l h v e a v e h f l e d U n y t r l u e A a s

r n l T A r $ u d e

l p d m w l h e i 9

a

s d l a a i p e

e

F w o ,

t w e 1 C

m t

a . c c o m a a s a U o n

b r e

o t d o h r l 3

o

w 0 o e w p a m r c

t Y a y o l e v d K n p t e t t g r

r f y f a o h

- a

r 6 2 r e h i l a i s

u o o i a t

i a o m e

y F s m

d

v i l c p t n i n i s g P s , n e

W

s o d C t p

n h e e r m e m f m 0 t . l e k s t h g t g i l

i h r t r n

a p o

w p s i

e o 0 g t t

e o p s

f a e t i a i H a i

d c E 2 a r r h f P n l d n p o m i o

d s 0 v r

r

s m

a n y s t r r t o o o a S e i l t f s y o a T e 0 u i a r a g g g r i c v s a l .

e i h k o , c s e

m f

i n e u f e y

r n c T h t l 2 i m

l e u e t h K C

g t o s r T

a t l i l c u e r

t t v , i c o s r i t p p

r d a

e . w n a

i r o i o e c e

n

l s e $ C h e a

” w i e s n e s m s s i

l t C p

n W a o s t g

n n e d

( y i 8 o w s t g s h i a u e a s h b t u r l f i A O v e t ,

c o … s 7

e l l n s e a

h

s

r e

w i

d a e d e b

a a C n i e t i r T s i o - o t r , c f . d i e c

n a r i m s o v 0 e a p n o u d

T t r r

r m l W

. a g d f o h n m r r e

a

i T u e t 0 m d ” i

s l l s r e R d e s

t e a t t r e i u p

e l t e a

n s a m 0 ,

o

h h D y h d i e y

d h t a o

a n U

n I s m d t r i M a s r r a o

l e

d o n a e s , l e e

-

f

s

i s o t c

F b u d e e

S

M n r n A t

t f i i t u

r

f

s n i t g i h o e a v h v e n h m s u e s d

e k s o c T a d p l c u t a e n

t e i a g b l t s u w e

e e n n t i h h E n o

i l e

s o

d p f s n l b f

y t o i n l l m s m r n e u y

E o d y s o l e . d

e n e u c a

, o p o

w e

a

c e

p i , a S n n

, o

c

P c u g t e n 5

n a r o B n e

T u h s n h i s t d

s t t e . s - n g n e

r g r . o

e d h i t r a 6 d D

t o e s m u

d

a g

r o f

.

e s

n

n d

s l

f e i

e

c t . n w t * D E P D D o i I S S O H M C t H G R C H T M E X M B A H M W C H D B M 2 S H M B S M L M B U L W D M S B D M K K n n o u u e n k i f t i u r l r t r e u u e e a i e a h o a o a a n i e y l e e y n 0 e o

g

a a a a a a a f f a o a o h r u h r s o a i f k k l a a t

l c d o t e g e l r n m r m r r i n n u g k r a v n g o p w n t r d f s s s s e a h H b l T m n i i h a n l v 1 f v v v e a

o t n e t - k l k c c t t t n e h e c a u C m o c s s s s e a a e e a m h e a

e H e a a e a i R e i d d

J p p s m o c h 2 p t

l G I a l l m a a a a a i t a m r t S t l s e t r l n i i e r l S y o o E

r r G h r h s e n

y o a n u a a i e m t e s i u i y e i h m F s l I o m c c N c c

e d d d c n

n t t , a y r w p e r n e u e i a i n n e

r W t a r r t i n r r i o L g

e c i l

A a r s h h h h

o

b c i s

y s e t a t g a P e a a t x a a n a B m m a B s r o K a U M U z l e a P

i H e u

i m

y e a u u u u e r i

n s y i B B u w l n t

r K - n l t U

d

d h y a l n

t P C n d a m e c u i n n

i S i a l u i l

T K n s s s s a D h n

i e i e e k n

v n a a a o B

m

. i c e t

E n o n L t , n

b e k n M i i r

t o e e e e e r a R c I d I D m u D o , i m n e d z

a o o n e t i a v v f V

h e o n n n d d n

x

i m i a P

d e r r i r t t t t l

r t

e t b w s . r e P

T i v l t f m e e e S o g z s t t t t , ,

e M e a

c i h a w s W s o i e t e e t

E c s

l H h

r 1 s s s s

d T

e l , n a - a h - e T r r h g A n h , , p t T t c i i e m P P p n u R

i e e a

m a S f . S a

e s s o n i i e a s r g r o o c M

. u a o h f D G G I I P

P t s t t n r o n

u h h a s s l g i i D y R p e s

e a n n o s e s u u , , m i f C i e o

r n t t s l l r f . e e h v h n i n , t . .

. s t e i S a t y y s c . q n s s f t d e o t t h o t

a a n D P D P M s f D i e o a s i

, n n . . e e e

y n P a t a o t t t c t c t

c r u B

D D

u g d e M P . h . h ,

. n o i i , S i i e e c n

P D

t c I r g h

o

v , h t t

i a f f i o . s . e t g i

. . r T r r a C f

t u u P r r ' r o o o h * i h e h . M e D D f o r N e s i I M r y a g s n a a h e

i D n v p c t t n h o o r r n . n u n d

e a

o

. . R d e e i o i l l d D i

A H c

C . a M n d . . d t l s

i s

t n B B e

l i S

, i P

D e e H H a

o . a e c R h t m o o

t

o o i e i d f s s . i i h e i r A i P N F n r . p f t t o o o H e g o o f f c

n s f t c e s a

i i d R e m

t h r g n c n a H r t s s p

n m m

o

T T . G u g s t c a h i e I

P o .

* t p p m g g i e e c s n n V a a D s u a D o t i i g e e t l e M f t v r i i e i

u c c a a l r

i j i

l f n s l . t t P m d d r o A y i

n a e r i a v S a

a a n h h l l c o M a

e u c T r g i i t e

c a t x v i t c e l l c c e n n e g o s n C n d i a i i l

r o a h t r o i o n e l C o a a a o o n

s s i c i

e s

d f

n s o b n c n P F M n -

e p l l s l l i t t o r n s i C R

o o n

a e e y a

o

e v c a

R R h m D t t i o l a H g g

o t

l n e l e e b e

e r o S e e i i f o

f a m e y y a l o m n r

r w p p S

i

o a s s f t M a A n o t a s n t s

r o o c m h e e

m p

a l m i i d t d L

D a u r t h e a a h e a

I l e t e a

d a e P t n o a n r r

i e

C n a

s o r t M c c l i x o s f D o d d h i c v h d a l l s a h h

u

l u t a s

t 2 e o a b O a t

e n I i r a G

e o

n l m

i p e T n

p e l B ( s n n i P e f e a m m t t c i i o p r y c

o s n r r r u a A r

e e e o

g T e i o i m d a i l n n n - s n e n n a O m n i

t s t m a r e t s P A R i i d s

e - n t t

M e I g

e i i A p

C

n n o g o A p i m l c n o 2 n t

f f a t g e

l t t g i ) a , V

n i d o i s

v n

m P a t P r t e i a i g

t s h n s o i m t c e i y a p o u s a s l u n

l i t a l c o

a r a r t

i y l o n [ 1

3 The Medical Foundation ⁄ a Division of HRiA ] Edward N. and Della L. Thome Memorial Foundation, Bank of America, N.A. Trustee, Awards Program in Age-Related Macular Degeneration Research A Program sponsored by U.S. Trust, Bank of America Private Wealth Management 2011 Award Recipients John Atkinson, M.D. Washington University School of Medicine in St. Louis The Edward N. and Della L. Thome Memorial Foundation was created in 2002 to A Novel Mouse Model of Dry Type Age-related advance the health of older adults through the support of direct service projects Macular Degeneration and medical research on diseases and disorders affecting older Americans. In Catherine Bowes Rickman, Ph.D. keeping with the Foundation’s mission, the Trust supports research in age-related Duke University macular degeneration (AMD), the major cause of blindness in older adults. The goal Contribution of Complement Dysregulation to of the Awards Program is to support translational research that will lead to improved AMD Pathogenesis

therapies for individuals suffering from AMD. The Scientific Review Committee is Mina Chung, M.D. chaired by Joan Miller, M.D., the Henry Willard Williams Professor of Ophthalmology University of Rochester and Chief and Chair of the Department of Ophthalmology, Massachusetts Eye and Adaptive Optics Imaging of Geographic Atrophy Progression in Macular Degeneration Ear Infirmary. Since its inception, the Program has awarded $14.7 million to 22 investigators working on translational AMD research in nonprofit academic, Anne Eichmann, Ph.D. medical, or research institutions across the United States. Yale University Inducing Vessel Quiescence in Age-Related In 2011, from 120 applications, eight investigators were chosen, each to receive Macular Degeneration $750,000 over three years. During the first year of their respective awards these Lindsay Farrer, Ph.D. investigators have made substantial progress, including unprecedented analysis Boston University of the temporal sequence of AMD progression, establishment of new AMD animal Genetic Mechanisms Shared by Eye and Brain Diseases as Novel Therapeutic Targets for models and the identification of novel contributing genes and metabolic factors. Age-Related Macular Degeneration Researchers are examining the relationship between amyloid-beta deposits in the eye and AMD, while others dissect the disease’s underlying signal transduction Douglas Vollrath, M.D., Ph.D. Stanford University pathways. Studies are also well underway to explore the complex role of microglia, Modulating Metabolism in Mice to Understand a type of immune cell, in AMD. Collectively, this innovative work is leading us and Treat AMD towards finding new targets for therapeutic intervention. Howard Weiner, M.D. Brigham and Women's Hospital Indigenous Microglia and Recruited Monocytes in AMD: Role in Pathogenesis and Immunotherapy by Specific Immune Targeting

Donald Zack, M.D., Ph.D. The Wilmer Eye Institute at Johns Hopkins Development of a Neuroprotective Molecule for the Treatment of Atrophic Age-Related Macular Degeneration

A i R H

f o

n o i s

i Program Officer Geographic Eligibility Award v i

D Linda Lam United States Three-year awards

a

⁄ [email protected] in the amount of n

o Research Focus $750,000 i t

a Program Eligibility Translational research d n

u Faculty at nonprofit that will lead to im - o F

research institutions proved therapies for l a

c (next grant cycle individuals suffering i d

e in 2013) from AMD M

e h T [14 ] www.tmfgrants.org/ThomeAMD E F w F P L P I A E L r i ( r i A D A a N t D A T t M t i s I t p n i m i s s n n m m e n n h o o n h e i L a r r c t n w d

h r e w n l s i o o e r . i n

o a P s z e e v a a c o r d n r w r A e d a t d a m p d u w a g g x w e m e a u e h e e r o

d t y

r t a t a r r t b . u 2 d m . e

r

r e e

l u o c r a a a e s

a t w r e e v t @

r u s p i g o o m 0 h d c y L c c u w a d i a m m e g t t a r n r r g i m n o n v r d

1 h a g i o h m a f n c a d r a s t a n g i r g

o t g o i s e m 4

t s e

r n E O e e r a a e i t r . h v l i a r i t i u T d a p v

n r

) l e t

a

t f o N a a h

g d n m b e s i o I T

f k

t

l d a e t l s s a . g o c i n r l n D r q h n f s o a o , e o i

c

f a t s . h u o y i

’ y s

n t s c i n m

e a r s b

s e u e

t r r n d s t s t s

s c t s g

a r e

u t e a p h e s c r i .

w r t

i h c p

w l o

a e e l o t d i i a t e o n

r l

l i t A s e

e e t t s

i r h e i o s t o S

l A a i d r o

u i m h i v l y g i d e t i i

P m c

a N f s l e

n f

n a t h l c

i

i / z b T e c t s i i P s a o t s

n e T a u t s c c e e s y

l i h D

s u i e

h o h

l r e r a i T l

v o u l p h e o d

. A o c

c

e o t o n t b

I o e n e s o r h h r o n a r f l o

, n m o h g i i o e o m e m l

e

c

t m f d e

a v e l n g l , s v w d i e e

l a

d c d i . a f g i e t -

t

k A y e i

e i i - n i e h

M n h e b b u

e e n t A c A s n s D R n L e s b B t

r d r a r g g e e r s e

e F d

b s t .

a y ’ e

R e a i r s i i t e

A d

r r t a G U R I d t t s A a I d n

o i g v e

p

T n h h a d d a l n a a d i

T u U d e y e e i w s l a n b n i

u d s a t n a e z t h

f d r i i d p o s

s i p a m a e v

c f h i i t c s . ( t r n s e o u t n i n i t e

e g c o

e t S o a D u A a l e t o i s o a

e s e e w v a

i l a e t

e r r s d t p R

n v t d o

m d e . t u a i ; a i a 2 a r t b a o r f l i m k u l n w e t

i s

. i h

l a

c t u e f

p a e e

o , l e T l t o

0 s x S i e F g r

. d t M s e

v h i i e h e o t s

l y a s n p

n r e e c e i t

t f

e e 1 t i C

o

r i R c e

f a

u h n o l g o e F a d f c s r r a ’ c

a . M s .

o a s o t 2 u s o i v e d o o f o s

r

l e n e e d

u ) e

t

t t r E o c S m s c m ( e r

d

, t t n i y m s i f i

a e n r

s f u l f n A e o w

e , o e i t u r

u , e i i i l s A n f o t

d s t m e

g a g

s e o s

s n e n

h B m D h l v

d

c L e e

i m r i a

a a i e s p

a A r m b c m , t e a i e a a o e e r o d l L ) v

i s r t i r x i i i h s e n r s . b

n e c i i l t m a

r c n z p e

d r e p o p i

p a

t m T D

i . . w t g k d c T r o r h e a g t u o

y n r l l c o r p h n h r

B

e

e o t i e a h o i l e

i u v i f o c i

h t

n d T o i o m l g n l r r d e

v h F y r e e s n h t e f i e e i o

u c m s r d s e n e

v

s i

o

o g r u e h A v f d m

g i t A n e n r

d a a u p f u w i

a e i n c g m

o

a s s d D e l t

i n c m o w

a n n

h i i s t t a i t A n M c n r t s e c a h o o l . i d d d

T A a h a h a l

g

d h t l r g m l

n m w c e m w T i t z i a h

i e t

o i i a e n a n r a

e

b c i e o c r ’ o h a h t M m o a t o e s f t p a g r g i m - h h x r r

m a o u e o

r e n t y d e , g d t a p

o

p S

e o

e r n e h i t n a s

e i

i

a P ’ i m p s u i h a n e s t c m r A

n b e

e e s n

N t r

p i r r o t n o e a r i i c a p

w y

M

e s

e i r e n d t f a o a d A n p v s l d

y r

l

i

r r s n w a $ g

s . D r f e c n a e e w e o r

D s ’ F i o o y 2 s c e r t a

o n A a e t

p e n p

r e i t d

a o r

0

r e i o .

t f j h v s

a n s d d g

i o t e o

i a i 0 r u o s

i n m c

o L e . u s e t m d n W a n s s i c s r , o

f

n s

0 l i

g P

p

i M t i e s d v t - o R f t p t n t e A d 0 d i e e s T

H a h e s

v e d p r v i

a e 0 a e o P

r a b I a v t o r t

e e d a i

o h T u u r m t i i s a g v i n l t n g e r n n l e

d t e

r t i e r

y e g i o e d u i o c n r h t e t e a

g

y v u

s . a i s

a g t f A i e n l

a o

w w n l d e

o u a

s M

o T m r e a c g D , f d v e r

d r i a

l d s

i f s a i e o r s

e a C d a B e r t t

,

m a t a l e c h n c

u m a

a l p h n

c e o s

t i a d

d o p e e d n ,

g l h

p a e t m u i

H n p i a v e

p l n r

e d P s e g s r a i f d

e d k o t d n o m t

o f e e t

e i r q o t e r

i u h o i o ,

n a o w s o s

v m o y u i r r i p n t n e

n

c f c o e t

i f h a o e e t e s n i a

r

d h

o v r n e r A i o e e f s u A s n s n g n a d v

e e

f r s s

m v a e t p

D o d e t n

f s

o f t a i t o t

H t p r r i v r

h a

t r e r o g d l d o u y a a e e o i

t u e r

i d

a m e e r n n c o

s s r i

g u c d a n t r

k e e d d u

h

a g r t d a l t

s i u e e , o s o r

c g s

c n t h f A i o C H P R I A A B P I V P 2 U L U D W S B D n o d n . u f a T r h a u o a l D r

n n e 0

i r

z e

h Y i i s i J a n a A i v s s v

v i i o g c g h 3 e n l i T v v e 1 t s i a t i d i

i t l n h o e i v d o d f e M e e 3 a z p e t a e

n e 2 f i a n p

o P n h i r r u r f

h

s 1 P

r m M H o i D s s E m e

e t

L u t b e c e o / C o U r i i

A u a y e x

i A g o i t t e i a M

a p o d n r h m l

y y p a n r s

T w l r

r t d t C t a J r d e

i S a e i g n i

e ' o r a a i o o o e

s e v U t o q e a s a r

a u d I i d h s g f f

n e l n M r n n a u , s c n

D l n

e b r ' e y

e r W S i

W s n - s c s i e i M , d 2 , o s o l t s T i r v t

i

, o

t

s y t , o i i D f P t

o i M e d o a e

y .

t t u e

p , I P s R D M n y u m S r h f

l r r n e i c t a a .

e P h i s g s

. t h . D z m A l e h S . e , o e s s e

D

i . h e D

a

o 5 t D . i b e e c n n c

P F a . . y t b , a . t f f

D e .

- ' s l h e , i o s

i h

l P i s P o o 6

M A l d t p i . o t e r . P

o n h r n a o

D M

H

l o i i I e h B r - z T .

s

d n e . l s o D M T o d . h o i i

h a D t h

o o n s o . f i e l i f a e

c e v p . m i x o f t C M i b d

r e a m c i i s r M a c o e t i i

l u e t a s t A p

i l d e i e h t C l t l o l o y e i e e a r l d e l c n e n '

o s u g b s i f

a n

c

o s P e

t o a t l t D i t i r h

c e t s r e n

o R r e i a

s D r o s r e f a e v

i t

e p r c f

M s e o u M T a i

e n c M r r g e s a

e o t

e

d i G r o D a d o i c d t c l n i i u h m f s i u y

n t c

a l e e a o m n t v o t e a

r r s t y e

[ 1

5 The Medical Foundation ⁄ a Division of HRiA ] Richard and Susan Smith, Co-Chairs

Smith Family Awards Program for Excellence in Biomedical Research A Program of the Richard and Susan Smith Family Foundation

2012 Award Recipients Since 1992, the Smith Family Foundation has been dedicated Mark Andermann, Ph.D. Beth Israel Deaconess Medical Center to launching the careers of outstanding junior faculty in basic Cortical Networks Guiding Hunger-Dependent life sciences research with the ultimate goal of accelerating the Attention to Food Cues pace of meaningful medical breakthroughs. Prior to application Jessica Cardin, Ph.D. submission, each institution conducts its own internal review Yale University and chooses the two most talented researchers to apply. Each GABAergic Contributions to Neural and Cognitive application is then carefully scrutinized by at least two prominent Deficits in a Genetic Model of Schizophrenia scientists on the Program’s Scientific Review Committee prior to Ethan Garner, Ph.D. the in-person Committee meeting. Tyler Jacks, Ph.D., Chair of the Harvard University Building a Mechanistic Understanding of Committee, is Professor of Biology, a Howard Hughes Medical Bacterial Cell Wall Growth using High-Resolution Institute Investigator and Director of the David H. Koch Institute Dynamic Imaging for Integrative Cancer Research at MIT. He received one of the

Elsie Sunderland, Ph.D. first Smith Family Awards in 1992. Harvard School of Public Health Sources, Trends and Effects of Immunotoxic Having just concluded its 21st year, the Program has funded Perfluorinated Compounds 130 scientists for a total investment of $23 million. The Foundation hosts an annual scientific poster session during which current and Eduardo Torres, Ph.D. University of Massachusetts Medical School former Award recipients and their laboratory members present Role of Protein Turnover Pathways in their research findings and interact with colleagues. Local recipi - Aneuploid Cells ents of the Pew Scholars Awards and the Searle Scholars Awards are also invited to this event. The Smith Family Foundation welcomes contributing partners to support the Awards Program. The Jessie B. Cox Charitable Trust, the Dolphin Trust, the Richard Allan Barry Fund at the Boston Foundation, the Ludcke Foundation, the Nancy Lurie Marks Family Foundation, and several anonymous donors have provided past support. Model depicting the outside cell wall of rod-shaped bacteria. Cell wall synthetic machines (blue spheres) move around the cell circumference in both directions, knitting in bands of new cell wall (yellow stripes). Courtesy of Ethan Garner, Ph.D.; Illustration by Janet Iwasa

Program Officer Geographic Eligibility Award Gay Lockwood Massachusetts, Three-year awards in the [email protected] Yale University amount of $300,000 and Brown University Program Eligibility Investigators within Research Focus two years of their first Basic biomedical science independent faculty appointment

www.tmfgrants.org/Smith Davis Foundation Postdoctoral Fellowship Program in Eating Disorders Research A Program of the Hilda and Preston Davis Foundation

The Hilda and Preston Davis Foundation was established “to In 2012, the Davis Foundation hosted a meeting in New York City advance the development of all areas of the lives of children that brought together Scientific Review Committee members and and young adults ... with special emphasis ... on those suffering the Davis Fellows to foster career development, discuss recent from eating disorders.” After consultation with academic and research findings and forge future collaborations. The Foundation governmental experts in eating disorders research, the Davis is pleased to support this year’s talented Fellows who are conduct - Foundation established the Fellowship Program to increase the ing gene discovery in anorexia nervosa, developing potential new number of outstanding neuroscientists who explore the biological targets for drug development, and studying the basic biology of causes of anorexia nervosa and bulimia nervosa. Since 2009, feeding behavior in rodent models. twenty-five postdoctoral investigators from across the United States have received Davis Fellowships. 2012 Award Recipients The long term goal of the program is to accelerate medical Pushkar Kulkarni, Ph.D. Northeastern University research discoveries that will lead to effective new therapies. Positive Allosteric Modulators of CB1 Cannabinoid Research areas of interest include but are not limited to neural Receptor for the Treatment of Anorexia Nervosa pathways of feeding behavior in animal models; molecular genetic Dong Li, Ph.D. analysis of relevant neural circuit assembly and function; testing Children's Hospital of Philadelphia of new chemical compounds that might be used in animal models Whole Exome Sequencing of Extreme-Trait as experimental treatments; and brain imaging technologies that Anorexia Nervosa identify neurochemical pathways in patients with these disorders. Stephanie Padilla, Ph.D. University of Washington Defining the Circuits and Cells Downstream of AgRP Neurons that Determine Food Intake Behavior

Erin Rich, M.D., Ph.D. University of California Berkeley The Role of Limbic and Prefontal Cortex in Coding Food and Non-food Values

Sara Trace, Ph.D. University of North Carolina at Chapel Hill Cross-Disorder Genomewide Association Studies in Anorexia Nervosa

A i R H

f o

n o

Brain circuits that process rewards i s

Program Officer Geographic Eligibility Award i v

and punishments. Waveforms of a i

Jeanne Brown United States Three-year fellowships D

a

neuron recorded from the macaque brain. [email protected] in the amount of ⁄

Courtesy of Erin Rich, M.D., Ph.D. n

Research Focus $141,000 - $177,000 o i t

Program Eligibility Basic research with a d n

Postdoctoral fellows direct relevance to u o F within their first three the biological l a years of training causes of eating c i d

disorders e M

e h T www.tmfgrants.org/Davis [17 ] Lymphatic Research Foundation (LRF) Postdoctoral Fellowship Awards Program and the LRF Additional Support Awards for NIH-Funded F32 Postdoctoral Fellows Programs of the Lymphatic Research Foundation

The Lymphatic Research Foundation (LRF) was established in Working with genetically altered mice that lack lymphatic 1998 to advance research discovery in the lymphatic system and vessels, she is exploring how the lack of lymphatic vessels impacts to find the cause of and cure for lymphatic diseases, lymphedema, immune system development. The Scientific Review Committee and related disorders. In only a few years, the Foundation created will assess the research progress of all Award Recipients successful alliances with academic institutions, professional asso - following completion of their first year of support. ciations, industry, and the National Institutes of Health. These LRF sponsored an educational symposium in 2012 in efforts have led to the scientific community responding with conjunction with the Cancer Center of Santa Barbara, greater attention to the lymphatic system and the important role entitled “Lymphatic Research Symposium with an Emphasis it plays in diseases afflicting millions. on Lymphedema and Cancer.” LRF is planning a series of live- Since 2005, LRF has partnered with The Medical Foundation streamed symposia throughout 2013 to highlight areas of division to create and manage the LRF fellowship programs. interest to both researchers and patients. LRF welcomes all The goals of these Programs are to expand and strengthen the opportunities to bring together researchers and the patients international pool of outstanding junior investigators in the field who stand to benefit most from their efforts, sparking new of lymphatic research. Fellowships support researchers who have understanding on both sides. recently received their doctoral degrees, a critical point in the career development of young scientists when they are choosing their future research paths. 2012 Award Recipients Carolyn Bayer, Ph.D. (F32 Fellow) Recipient of the F32 Additional Support Award for NIH Fellows, University of Texas at Austin Carolyn Bayer, Ph.D. is tackling an especially challenging problem. Molecular Photoacoustic Imaging Her research seeks to use different imaging modalities, combined Using Multitargeted Contrast Agents with tissue-targeted contrast agents, to acquire non-invasive Alireza Haghighi Kakhki, M.D., Ph.D. images of the lymphatic and blood vessels associated with tumors. University of Oxford Alireza Haghighi Kakhki, M.D., Ph.D. proposes to identify the University of Pittsburgh Genetic Basis of the Yellow Nails- mutated gene that causes a rare inherited form of lymphedema Lymphedema-Pleural Effusion and may lead to a better understanding of its role in lymphatic Syndrome development. Yiqing Yang, Ph.D. is studying one of the fundamen - Yiqing Yang, Ph.D. tal relationships between the immune and lymphatic systems. University of Pennsylvania The Interaction between Lymphatic William Repicci, LRF Executive Director and Phyllis Fried, M.D., Vessels and Secondary Lymphoid

Organs in Development

A LRF Research and Program Coordinator i R H

f o

n o i s i Program Officer Research Focus LRF Additional Support v i

D Clinical and basic Award funds only U.S. Linda Lam a

⁄ [email protected] science research NIH Fellows whose n

o relevant to the research is relevant to i t

a Program Eligibility lymphatic system the lymphatic system d n

u Postdoctoral fellows and LRF’s mission ($20,000 over two years) o F

l within their first three a

c Award i years of training d

e Two-year fellowships in M

e Geographic Eligibility the amount of $82,000 - h T Worldwide $95,000 [18 ] www.tmfgrants.org/LRF 2012 Scientific Review Committees Each year, Scientific Review Committee members contribute their expertise as well as hundreds of hours to read, discuss and ultimately recommend to clients the most outstanding applicants for funding. We are grateful for their service and thank them for their commitment.

Charles A. King Trust Charles A. King Trust Deborah Munroe Noonan Klarman Family Foundation Postdoctoral Fellowship Program Postdoctoral Fellowship Memorial Research Fund Grants Program in Eating (Basic Science Research) Program Disorders Research Laurel Leslie, M.D., M.P.H. (Chair) (Clinical and Health Services Research) Phillip D. Zamore, Ph.D. (Chair) Andria Amador, CAGS, NCSP Joel K. Elmquist, D.V.M., Ph.D. (Co-Chair) Ingolf Bach, Ph.D. Jane Weeks, M.D., M.Sc. (Chair) James Glauber, M.D., M.P.H Timothy H. Moran, Ph.D. (Co-Chair) Stephen C. Blacklow, M.D., Ph.D. Ann Aschengrau, Sc.D. Karen Kuhlthau, Ph.D. Regina Carelli, Ph.D. Steve Buratowski, Ph.D. James I. Hudson, M.D., Sc.D. Susan L. Parish, Ph.D. Esther Dechant, M.D. David M. Center, M.D. Gordon Huggins, M.D. Leonard Rappaport, M.D., M.S. Sabrina Diano, Ph.D. Constance Cepko, Ph.D. David M. Kent, M.D., M.S. Richard Robison, D.Min. Irwin Lucki, Ph.D. Michael J. Eck, M.D., Ph.D. Nan Laird, Ph.D. Michael Silverstein, M.D., M.P.H. Emmanuel Mignot, M.D., Ph.D. Bennett Goldberg, Ph.D. Bruce E. Landon, M.D., M.B.A., M.Sc. Martin G. Myers, Jr., M.D., Ph.D. Dale L. Greiner, Ph.D. Carl-Fredrik Westin, Ph.D. Edward N. & Della L. Thome James B. Potash, M.D., M.P.H. Robin R. Ingalls, M.D. Memorial Foundation Awards Linda Rinaman, Ph.D. Michelle A. Kelliher, Ph.D. Charles H. Hood Foundation Program in Age-Related Macular Gary Schwartz, Ph.D. Vijay K. Kuchroo, D.V.M., Ph.D. Child Health Research Awards Degeneration Research Scott Sternson, Ph.D. Anthony G. Letai, M.D., Ph.D. Program Joan W. Miller, M.D. (Chair) Eve Marder, Ph.D. Lymphatic Research Foundation Stella Kourembanas, M.D. (Chair) Anthony P. Adamis, M.D. Matthew L. Meyerson, M.D., Ph.D. Awards Programs Bobby J. Cherayil. M.D. Constance Cepko, Ph.D. Melissa J. Moore, Ph.D. Jonathan M. Davis, M.D. Emily Y. Chew, M.D. Mihaela Skobe, Ph.D. Carl D. Novina, Ph.D. Marie E. Egan, M.D., FAAP Gregory S. Hageman, Ph.D. Reza Dana, M.D., M.P.H., M.Sc. Mary-Lou Pardue, Ph.D. Jordan Kreidberg, M.D., Ph.D. James T. Handa, M.D. Michael J. Davis, Ph.D. Norbert Perrimon, Ph.D. Mary M. Lee, M.D. Sabri Markabi, M.D. Mark Kahn, M.D. Daniel Remick, M.D. Stephen Pelton, M.D. Tom Reh, Ph.D. Jan Kitajewski, Ph.D. Dagmar Ringe, Ph.D. David W. Rowe, M.D. Cynthia A. Toth, M.D. Nancy Ruddle, Ph.D. Josh Sanes, Ph.D. James Sargent, M.D. Alexander Schier, Ph.D. Susanne E. Tanski, M.D., M.P.H. Edward N. & Della L. Thome Smith Family Awards Program Ralph Scully, M.B.B.S., Ph.D. Elizabeth Thiele, M.D., Ph.D. Memorial Foundation Awards for Excellence in Biomedical Hazel Sive, Ph.D. Paige Williams, Ph.D. Program in Alzheimer’s Disease Research Gary S. Stein, Ph.D. Drug Discovery Research Vickery Trinkaus-Randall, Ph.D. Tyler Jacks, Ph.D. (Chair) Davis Foundation Postdoctoral LiHuei Tsai, Ph.D. (Chair) Catherine Dulac, Ph.D. Philip Tsichlis, M.D. Fellowship in Eating Disorders Kelly R. Bales, Ph.D. Larry Feig, Ph.D. Da-Zhi Wang, Ph.D. Research David J. Waxman, Ph.D. Greg M. Cole, Ph.D. Leslie Griffith, M.D., Ph.D. Matthew A. Wilson, Ph.D. Roger Cone, Ph.D. (Chair) Bradley T. Hyman, M.D., Ph.D. Louis Kunkel, Ph.D. Gary Yellen, Ph.D. Angelo Del Parigi, M.D. Marty Jefson, Ph.D. Bradford B. Lowell, M.D., Ph.D. Catherine Kotz, Ph.D. Frank M. LaFerla, Ph.D. Ann Marshak-Rothstein, Ph.D. Eleftheria Maratos-Flier, M.D. Patrick C. May, Ph.D. John A. Porco, Jr., Ph.D. Eric J. Nestler, M.D., Ph.D. Pierre N. Tariot, M.D. Gary Ruvkun, Ph.D. Mark W. Sleeman, Ph.D. D. Martin Watterson, Ph.D. Bernardo Sabatini, M.D., Ph.D. Matthias Tschoep, M.D. Ryan Watts, Ph.D. David T. Scadden, M.D. Hui Zheng, Ph.D. Matthew Waldor, M.D., Ph.D. a T 9 B 6 w

1 5 o d h w 7 s i B e . v t w 2

o e i M 7 . s r n t 9 i k m o , e .

e 2 M n d f l 2 g e

i c o 4 A y r a a f 0

l S n

H 0 e F t t 2 r s x o R e 1 . t o u 1 e . i 3 6 r t n A , g 2

d S 0 a u t i i t o e n

2 0 8 B U P N P E O O . R S N M S - . A P P I T T R O O

N O S N F O I I T . T , 5 A

8 O M 7 G D R 1 A E G 7 .

Design: Rose Srebro Design. Newton. MA