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(c) GROWTH FACTORS AND THEIR RECEPTORS: (M) CELLULAR AND MOLECULAR BIOLOGY GENETIC CONTROL AND RATIONAL APPLICATION OF MUSCLE DEVELOPMENT Sponsored by: Abbott Laboratories - Cetus Corporation - Genentech, Inc. - Sponsored by: The Director's Sponsors Fund Smith Kline & French Organizers: Frank Stockdale and Laurence Kedes Organizers: Russell Ross, Antony Burgess and Tony Hunter April 3-10, 1988 • Steamboat Springs, Colorado January 24-30, 1988 • Keystone, Colorado ABSTRACT DEADLINE: November 13, 1987 ABSTRACT DEADLINE: October 2, 1987

(N) MOLECULAR BIOLOGY OF RNA (D) GROWTH INHIBITORY AND CYTOTOXIC POLYPEPTIDES Sponsored by: The Director's Sponsors Fund Sponsored by: Genentech, Inc. - Smith Kline & French - Triton Biosciences, Inc. Organizer: Thomas Cech Organizers: Harold Moses, Peter Lengyel and Charles Stiles April 4-10, 1988 - Keystone, Colorado January 24-30, 1988 • Keystone, Colorado ABSTRACT DEADLINE: November 25, 1987 ABSTRACT DEADLINE: October 2, 1987 (o) DNA-PROTEIN INTERACTIONS IN TRANSCRIPTION (H) GENE TRANSFER AND GENE THERAPY Sponsored by: The Director's Sponsors Fund Organizer: Jay Gralla Sponsored by: E.L du Pont de Nemours April 4-10, 1988 • Keystone, Colorado Organizers: Inder Verma, Richard Mulligan and Arthur Beaudet ABSTRACT DEADLINE: November 25, 1987 February 6-12, 1988 • Tamarron, Colorado ABSTRACT DEADLINE: October 23, 1987 (P) STRESS-INDUCED PROTEINS MOLECULAR BIOLOGY OF THE EYE: Sponsored by: Hoffmann-La Roche, Inc. - The Director's Sponsors Fund GENES, VISION & OCULAR DISEASE Organizers: Mary Lou Pardue, James Feramisco and Susan Lindquist April 10-16, 1988 • Keystone, Colorado Sponsored by: National Eye Institute ABSTRACT DEADLINE: November 25, 1987 Organizers: Joram Piatigorsky, Peggy Zelenka and Toshimichi Shinohara February 6-12, 1988 - Santa Fe, New Mexico ABSTRACT DEADLINE: October 23, 1987 (S) CELL ACTIVATION AND SIGNAL INITIATION: RECEPTOR AND PHOSPHOLIPASE CONTROL OF INOSITOL PHOSPHATE, PAF AND (J) CELL BIOLOGY OF VIRUS ENTRY, REPLICATION EICOSANOID PRODUCTION AND PATHOGENESIS Sponsored by: Eli Lilly Research Laboratories Sponsored by: Glaxo, Inc. Organizers: Edward Dennis, Michael Berridge and Tony Hunter Organizers: Richard Compans, Ari Helenius and Michael Oldstone April 17-23, 1988 • Keystone, Colorado February 28-March 5, 1988 • Taos, New Mexico ABSTRACT DEADLINE: January 4, 1988 ABSTRACT DEADLINE: November 13, 1987

(L) THE MOLECULAR BASIS OF PLANT DEVELOPMENT Sponsored by: E.L du Pont de Nemours Organizer: Robert Goldberg March 26-April 2, 1988 • Steamboat Springs, Colorado ABSTRACT DEADLINE: November 13, 1987

(detach here) (C,D,H,I,J,L, INFORMATION REQUEST FORM M,N,O,P,S)

Please send me program and application information on the 1988 UCLA Symposia on Molecular & Cellular Biology.

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Please mail to: UCLA Symposia, 103 Molecular Biology Institute, Los Angeles, CA 90024-1378 Telephone" (213) 206-6292 Telex: UCLA Symposia 9103427597 VCH PUBLISHERS Publishers of Angewandte Chemie, Chemische Berichte, Liebigs Annalen, and Ullmann's Encyclopedia of Industrial Chemistry. V( FROM GENES TO CLONES: Introduction to THE ART OF SCIENTIFIC WRITING: From Student Gene Technology Reports to Professional Publications in Chemistry and E. L. Winnacker Related Fields This textbook on gene technology offers for the first time a H. F. Ebel, C. Bliefert, and W. E. Russey unified approach to the subject and summarizes the concepts Three scientists from both sides of the Atlantic Ocean and strategies behind the art of gene cloning. summarize their years of experience as authors, teachers, and The author describes the unit operations ofgene technol- editors for all those who want to know about scientific ogy and provides practical guidance on the isolation and writing and publishing. characterization of DNA and genes, the development of 1987 450 pp. ISBN 0-89573-495-8 Cloth $59.95 cloning vectors, and the characterization of recombinant ISBN 0-89573-645-4 Paper $24.95 DNA molecules. He also discusses in great detail the de- velopment and practical applications of plasmids, bacter- ELECTROPHORESIS '86 iophages, cosmids, phasmids, and eukaryotic viruses as clon- M. J. Dunn ing vehicles, along with the respective hosts, i.e., pro- 72 papers and 72 poster abstracts reflect the latest trends and karyotes, streptomyces, yeasts, plant cells, and eukaryotes. developments in electrophoretic techniques and their ap- Each chapter contains an extensive list of references; the plications. Articles on the analytical electrophoresis of pro- appendix includes information about frequently used host teins and on two-dimensional electrophoresis account for strains, restriction enzymes, restriction maps, sequence more than half of the contributions. data, and the 1986 NIH Guidelines for Research Involving 1986 765 pp. ISBN 0-89573-583-0 $99.50 Recombinant DNA Molecules. A very detailed index and more than 400 figures allow the book to be used as a METALLOPROTEINS reference manual. Pauline M. Harrison 1987 634 pp. ISBN 0-89573-420-6 Cloth $68.00 The essays collected here seek to arrive at an understanding ISBN 0-89573-614-4 Paper $34.00 of how metalloprotein molecules work and the relationship of their functions to their own structures and to the function and structures of other biomolecules. METHODS OF ENZYMATIC ANALYSIS Part one encompasses both molecules for which three- Third English Edition in 12 Volumes dimensional structures are already available and complexes Vol. X: Antigens and Antibodies 1 for which structural information is lacking or incomplete. It Vol. XI: Antigens and Antibodies 2 deals primarily with transition metals. Part two brings H. U. Bergmeyer, J. Bergmeyer, and M. Qrassl together six classes of protein to illustrate a variety of impor- These volumes provide working instructions for the de- tant physiological processes in which metals are involved in termination of antigens (proteins, viruses, and micro- association with protein. organisms with antigenic properties) and antibodies. They Some activities illustrated are enzyme catalysis, trigger- present for the first time a collection of enzyme- ing, and oxygen transport. immunoassay techniques in the format of working in- Topics in Molecular and Structural Biology 3 structions to promote and facilitate the diagnosis of viral, Part 1: Metal Proteins with Redox Roles allergic, and autoimmune diseases. 1985 256 pp. ISBN 0-89573-210-6 $59.50 Vol. X: 1986 509 pp. ISBN 0-89573-240-8 Regular Price $148.00 Sub Price $110.00 Part 2: Metal Proteins with Non-Redox Roles Vol. XI: 1986 508 pp. ISBN 0-89573-241-6 1985 339 pp. ISBN 0-89573-211-4 $69.50 Regular Price $155.00 Sub Price $116.00 Coming Soon... Now available... CHEMICAL SYNTHESIS IN MOLECULAR CUMULATED SUBJECT INDEX--Methods of BIOLOGY Enzymatic Analysis, Third English Edition H. Bltcker et al. H. U. Bergmeyer, J. Bergmeyer, and M. Qrassl 1987 226 pp. ISBN 0-89573-618-7 $65.00 A comprehensive index to the complete twelve volumes of Methods of Enzymatic Analysis. GNOMIC -- A Dictionary of Genetic Codes 90 pp. ISBN 0-89573-243-2 Regular Price $61.00 E. N. Trifonov and V. Brendel Sub. Price $47.00 1987 272 pp. ISBN 0-89573-658-6 $89.95

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DEVELOPMENT A journal devoted to the molecular analysis of gene expression in eukaryotes, prokaryotes, and viruses

INFORMATION FOR CONTRIBUTORS Manuscript Preparation Aims and Scope 1. General. There will be no set limits on the length of the pa- Genes and Development reports important advances in the pers published in Genes and Development. Short papers will be understanding of the molecular genetics of eukaryotes, prokary- welcomed if they present complete, rather than preliminary, data. otes, and viruses. All aspects of gene expression and regulation Papers of 10 or more printed pages will be accepted if the editors are covered, with a special emphasis on the elucidation of normal and referees consider that the information requires extensive ex- and abnormal development and differentiation as revealed by the planation and discussion. The entire paper (including tables, fig- techniques of molecular genetics. In the context of this special ure legends, references, footnotes) should be typed double-spaced emphasis, the editorial policy of the journal fully recognizes that on standard-sized European or American bond paper with at least many types of genetic research will help elucidate the relation- bin (2.5 cm} margins on all four sides. Computer printouts should ship between genotype and phenotype. Thus the scope of Genes be of letter quality. Each page should be labeled with the first and Development is much broader than "developmental ge- author's name and a page number. Five copies should be sub- netics" as conventionally defined. The journal welcomes high- mitted; at least four of these copies should have original art. A quality research papers concerning any organism or virus that ad- cover letter should include: [a) name, address, and telephone dress questions concerning the regulation and expression of genes. number of author responsible for correspondence regarding the The scientific excellence of the journal will be established with manuscript; {b) statement that the manuscript has been seen the active support of its international editorial board. Rapid pub- and approved by all listed authors; (c) any specific requirements lication of papers with a general interest will be a key feature of for reproduction of art; and (d) status of permissions needed for Genes and Development. The average reviewing time for reprinted tables and figures. papers is three weeks and publication time from acceptance of 2. Submitting Papers on Computer Discs. We can accept papers manuscript is between two and three months. Genes and De- on 51A-inch floppy discs or 31A-inch Macintosh discs in over 150 velopment is published by Cold Spring Harbor Laboratory and CPM formats and in IBM PC, AT, and XT [1.2 meg or 360K floppy}, the Genetical Society of Great Britain; both are independent Apple DOS, or compatible formats. Please supply the manuscript nonprofit institutions. on the disc as a "text" file, if possible. If a word-processing file is being sent, do not use any underscoring, italic, or boldface; spell out special characters {Greek, math); use two carriage returns at Submission of Papers the end of each paragraph, subheads, and list items. Indicate on The journal accepts papers which present original research that the disc: computer brand name, whether the disc contains a text has not previously been published. Submission to the Journal im- or word-processing file [name of software}, and the disc format. plies that a paper is not currently being considered for another Four hardcopy versions should also be submitted for use by ref- journal or book. It is also understood that researchers who submit erees and editors. papers to this journal will be prepared to make available to qual- 3. Style and Nomenclature. Manuscripts should be written in ified academic researchers materials needed to duplicate their re- clear, concise English using American spellings. Abbreviations search results {probes, plasmids, clones, sequences, and the hke). should be identified at their first use. General questions of style and nomenclature can be answered by consulting, CBE Style Contributors should submit their papers to: Manual Committee, Council of Biology Editors Style Manual: A Judy Cuddihy, Managing Editor Guide for Authors, Editors, and Publishers in the Biological Sciences, Cold Spring Harbor Laboratory 5th ed., Arlington, Council of Biology Editors. Genetic designa- EO. Box 100 tions for many organisms can be found in O'Brien, S.J., Genetic Cold Spring Harbor, New York 11724, USA Maps: A Compilation of Linkage and Restriction Maps of Genetically Phone {516) 367-8492 Studied Organisms, vol. 3, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1984. A compendium of tentative rules or and recommendations of international scientific unions can be ob- Grahame Bulfield, Editor tained from Biochemical Book Depot, POB 32, Commerce Way, AFRC Institute of Animal Physiology & Genetics Research Colchester CO2 8HP, Essex, UK ($7; £3). Edinburgh Research Station 4. Form. 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In upcoming issues of Genes & Development:

The mother-daughter mating type switching asymmetry of budding yeast is not conferred by the segregation of parental HO gene DNA strands Amar J.S. Klar Cell- and promoter-specific activation of transcription by DNA replication David S. Grass, Douglas Read, E. Diann Lewis, and James L. Manley Expression and assembly of a human neurofilament protein in transgenic mice provide a novel neuronal marking system Jean-Pierre Julien, Irene Tretjakoff, Lucille Beaudet, and Alan Peterson Alternative processing during development of a macronuclear chromosome family in Oxytricha fallax Glenn Herrick, Deborah Hunter, Kevin Williams, and Kenneth Kotter Spec3: embryonic expression of a sea urchin gene whose product is involved in ectodermal ciliogenesis Elizabeth D. Eldon, Lynne M. Angerer, Robert C. Angerer, and William H. Klein Deletion analysis of the achaete-scute locus of Drosophila melanogaster Mar Ruiz-Gomez and Juan Modolell Electrophoretic morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2) Elizabeth J. Lawlor, Howard A. Baylis, and Keith F. Chater In upcoming issues of Genes & Development: Research papers cis- and trans-acting sequences required for expression of simian virus 40 genes in mouse oocytes Lorraine E. Chalifour, Dana O. Wirak, Ulla Hansen, Paul M. Wassermann, and Melvin L. DePamphilis Defects in lens fiber differentiation are linked to c-mos overexpression in transgenic mice Jaspal S. Khillian, Marianne K. Oskarsson, Friedrich Propst, Toichiro Kuwabara, George F. Vande Woude, and Heiner Westphal Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis Stefan Baumgartner, Daniel Bopp, Maya Burri, and Markus Noll GAL1-GALIO divergent promoter region of Saccharomyces cerevisiae contains negative control elements in addition to functionally separate and possibly overlapping upstream activating sequences Robert W. West Jr., Shiming Chen, Henry Putz, Geraldine Butler, and Mary Banerjee Differences in DNA methylation during oogenesis and spermatogenesis and their persistance during early embryogenesis in the mouse J.P. Sanford, H.J. Clarke, V.M. Chapman, and J. Rossant Thyroid hormone induction of keratin genes: a two-step activation of gene expression during development Peter M. Mathisen and Leo Miller The identification of factors that interact with the EIA-inducible adenovirus E3 promoter Helen C. Hurst and Nicholas C. Jones

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