bioRxiv preprint doi: https://doi.org/10.1101/2020.05.19.103804; this version posted May 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold Rubén Hervás1,2*#, María del Carmen Fernández-Ramírez1#, Albert Galera-Prat1, Mari Suzuki3, Yoshitaka Nagai3,4, Marta Bruix5, Margarita Menéndez6, Douglas V. Laurents5 & Mariano Carrión-Vázquez1,* Running Head: Differential amyloidogenesis in CPEBs PLDs 1Instituto Cajal, IC-CSIC. Avda. Doctor Arce 37, E-28002 Madrid, Spain. 2Current address: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA. 3Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. 4Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama 332-0012, Japan. 5Instituto de Química-Física Rocasolano, IQFR-CSIC. Serrano 119, E-28006 Madrid, Spain. 6Instituto de Química-Física Rocasolano, IQFR-CSIC. Serrano 119, E-28006 Madrid, Spain. & Centro de Investigación Biomédica en Red sobre Enfermedades Respiratorias (CIBERES). #These two authors have contributed equally. *To whom correspondence should be addressed. e-mail:
[email protected] or
[email protected]. Key Words: cytoplasmic polyadenylation element binding protein (CPEB), functional amyloids, prion-like protein, memory persistence, coiled-coils. 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.05.19.103804; this version posted May 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder.