December 2, 2014 u vol. 111 u no. 48 u 16975–17336

Cover image: Pictured is a vermillion sea star, Mediaster aequalis,inPorlierPass,British Columbia, that shows signs of sea-star wasting disease. As of June 2014, the disease had affected 20 species of sea stars from Alaska to Baja California, but its cause is unknown. Ian Hewson et al. surveyed sea-star populations and conducted laboratory infection studies. They found that sea-star wasting disease is likely caused by a virus and identified a densovirus as a potential infectious agent. See the article by Hewson et al. on pages 17278–17283. Image courtesy of Peter Luckham (www.divemaster.ca). From the Cover

17278 Potential cause of sea-star wasting disease 17075 Human ability to evaluate probabilities 17122 X-ray free crystallography 17140 DNA binding site recognition by regulatory proteins 17182 Ebola antibodies’ modes of action

Contents COMMENTARIES 16982 Going viral and the fatal vulnerability of neurons from immunity, not from infection THIS WEEK IN PNAS Lawrence Steinman See companion article on page 16053 in issue 45 of volume 111 16975 In This Issue 16984 Fuzzy universality of probability judgment Valerie F. Reyna and Charles J. Brainerd See companion article on page 17075 INNER WORKINGS—An over-the-shoulder look at scientists at work 16986 Expanding the femtosecond crystallography toolkit Sol M. Gruner 16977 Inner Workings: Freeing the dinos within See companion article on page 17122 Stephen Ornes

CORE CONCEPTS—A brief introduction to emerging topics in science PNAS PLUS

16978 Core Concept: Synthetic biology—change, accelerated 16988 Significance Statements Danielle Venton Brief statements written by the authors about the significance of their papers.

RETROSPECTIVE PERSPECTIVE 16980 David T. Gibson: From biodegradation to biocatalysis Caroline S. Harwood and Rebecca E. Parales 16990 Evolutionary cell biology: Two origins, one objective Michael Lynch, Mark C. Field, Holly V. Goodson, Harmit S. Malik, José B. Pereira-Leal, David S. Free online through the PNAS open access option. Roos, Aaron P. Turkewitz, and Shelley Sazer

PNAS u December 2, 2014 u vol. 111 u no. 48 u iii–vii Downloaded by guest on October 2, 2021 ENVIRONMENTAL SCIENCES INAUGURAL ARTICLES 17045 Rapid climate change did not cause population collapse at the end of the European Bronze Age 16995 Analysis of clock-regulated genes in Neurospora Ian Armit, Graeme T. Swindles, Katharina Becker, reveals widespread posttranscriptional control of Gill Plunkett, and Maarten Blaauw metabolic potential Jennifer M. Hurley, Arko Dasgupta, Jillian M. Emerson, Xiaoying Zhou, Carol S. Ringelberg, Nicole Knabe, PHYSICS Anna M. Lipzen, Erika A. Lindquist, Christopher G. 17050 Revealing an unusual transparent phase of superhard Daum, Kerrie W. Barry, Igor V. Grigoriev, Kristina M. iron tetraboride under high pressure Smith, James E. Galagan, Deborah Bell-Pedersen, Komsilp Kotmool, Thanayut Kaewmaraya, Sudip Michael Freitag, Chao Cheng, Jennifer J. Loros, Chakraborty, Jonas Anversa, Thiti Bovornratanaraks, and Jay C. Dunlap Wei Luo, Huiyang Gou, Paulo Cesar Piquini, 17003 Circular permutation of a synthetic eukaryotic Tae Won Kang, Ho-kwang Mao, and Rajeev Ahuja chromosome with the telomerator 17054 Force distribution affects vibrational properties Leslie A. Mitchell and Jef D. Boeke in hard-sphere glasses Eric DeGiuli, Edan Lerner, Carolina Brito, and Matthieu Wyart PHYSICAL SCIENCES

APPLIED PHYSICAL SCIENCES SOCIAL SCIENCES 17011 Charging-free electrochemical system for harvesting low-grade thermal energy Yuan Yang, Seok Woo Lee, Hadi Ghasemi, James Loomis, ANTHROPOLOGY Xiaobo Li, Daniel Kraemer, Guangyuan Zheng, Yi Cui, 17045 Rapid climate change did not cause population collapse and Gang Chen at the end of the European Bronze Age 17017 Instability-induced pattern formation of photoactivated Ian Armit, Graeme T. Swindles, Katharina Becker, functional polymers Gill Plunkett, and Maarten Blaauw Henning Galinski, Antonio Ambrosio, Pasqualino 17060 New insights into Eastern Beringian mortuary behavior: Maddalena, Iwan Schenker, Ralph Spolenak, A terminal Pleistocene double infant burial at Upward and Federico Capasso Sun River Ben A. Potter, Joel D. Irish, Joshua D. Reuther, CHEMISTRY and Holly J. McKinney 17023 Graphene cover-promoted metal-catalyzed reactions Yunxi Yao, Qiang Fu, Y. Y. Zhang, Xuefei Weng, Huan Li, PSYCHOLOGICAL AND COGNITIVE SCIENCES Mingshu Chen, Li Jin, Aiyi Dong, Rentao Mu, Peng Jiang, 17066 People search for meaning when they approach Li Liu, Hendrik Bluhm, Zhi Liu, S. B. Zhang, and Xinhe Bao a new decade in chronological age 17158 Orientation of aromatic residues in amyloid cores: Adam L. Alter and Hal E. Hershfield Structural insights into prion fiber diversity 17071 Rethinking natural altruism: Simple reciprocal Anna Reymer, Kendra K. Frederick, Sandra Rocha, interactions trigger children’s benevolence Tamás Beke-Somfai, Catherine C. Kitts, Susan Lindquist, Rodolfo Cortes Barragan and Carol S. Dweck and Bengt Nordén 17075 Probabilistic cognition in two indigenous Mayan groups EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Laura Fontanari, Michel Gonzalez, Giorgio E5123 Orbital apocenter is not a sufficient condition for Vallortigara, and Vittorio Girotto HST/STIS detection of Europa’s water vapor aurora See Commentary on page 16984 Lorenz Roth, Kurt D. Retherford, Joachim Saur, 17081 The association between discontinuing hormonal Darrell F. Strobel, Paul D. Feldman, Melissa A. contraceptives and wives’ marital satisfaction McGrath, and Francis Nimmo depends on husbands’ facial attractiveness 17029 Silicon isotopes in angrites and volatile loss V. Michelle Russell, James K. McNulty, Levi R. Baker, in planetesimals and Andrea L. Meltzer Emily A. Pringle, Frédéric Moynier, Paul S. Savage, 17087 Credit scores, cardiovascular disease risk, and James Badro, and Jean-Alix Barrat human capital 17033 Transition from geostrophic turbulence to inertia– Salomon Israel, Avshalom Caspi, Daniel W. Belsky, gravity waves in the atmospheric energy spectrum HonaLee Harrington, Sean Hogan, Renate Houts, Jörn Callies, Raffaele Ferrari, and Oliver Bühler Sandhya Ramrakha, Seth Sanders, Richie Poulton, and Terrie E. Moffitt 17039 Earthquake and tsunami forecasts: Relation of slow slip events to subsequent earthquake rupture 17314 Mapping the unconscious maintenance of a lost Timothy H. Dixon, Yan Jiang, Rocco Malservisi, first language Robert McCaffrey, Nicholas Voss, Marino Protti, Lara J. Pierce, Denise Klein, Jen-Kai Chen, and Victor Gonzalez Audrey Delcenserie, and Fred Genesee

iv u www.pnas.org Downloaded by guest on October 2, 2021 17320 Harm to others outweighs harm to self in moral 17128 Structure of the meningococcal vaccine antigen NadA decision making and epitope mapping of a bactericidal antibody Molly J. Crockett, Zeb Kurth-Nelson, Jenifer Z. Siegel, Enrico Malito, Marco Biancucci, Agnese Faleri, Ilaria Peter Dayan, and Raymond J. Dolan Ferlenghi, Maria Scarselli, Giulietta Maruggi, Paola Lo Surdo, Daniele Veggi, Alessia Liguori, Laura Santini, Isabella Bertoldi, Roberto Petracca, Sara Marchi, Giacomo SOCIAL SCIENCES Romagnoli, Elena Cartocci, Irene Vercellino, Silvana Savino, 17093 Static network structure can stabilize Glen Spraggon, Nathalie Norais, Mariagrazia Pizza, Rino human cooperation Rappuoli, Vega Masignani, and Matthew James Bottomley David G. Rand, Martin A. Nowak, James H. Fowler, 17134 Structural model of an mRNA in complex with and Nicholas A. Christakis the bacterial chaperone Hfq Yi Peng, Joseph E. Curtis, Xianyang Fang, and Sarah A. Woodson − BIOLOGICAL SCIENCES 17140 Protein DNA binding in the absence of specific base-pair recognition Ariel Afek, Joshua L. Schipper, John Horton, APPLIED BIOLOGICAL SCIENCES Raluca Gordân, and David B. Lukatsky 17099 Aptamer photoregulation in vivo 17146 Activity-regulating structural changes and Lele Li, Rong Tong, Hunghao Chu, Weiping Wang, autoantibody epitopes in transglutaminase 2 Robert Langer, and Daniel S. Kohane assessed by hydrogen/deuterium exchange 17104 NanoFlares for the detection, isolation, and culture of Rasmus Iversen, Simon Mysling, Kathrin Hnida, live tumor cells from human blood Thomas J. D. Jørgensen, and Ludvig M. Sollid Tiffany L. Halo, Kaylin M. McMahon, Nicholas L. Angeloni, 17152 Natural low-molecular mass organic compounds with Yilin Xu, Wei Wang, Alyssa B. Chinen, Dmitry Malin, oxidase activity as organocatalysts Elena Strekalova, Vincent L. Cryns, Chonghui Cheng, Tatsuya Nishiyama, Yoshiteru Hashimoto, Hitoshi Kusakabe, Chad A. Mirkin, and C. Shad Thaxton Takuto Kumano, and Michihiko Kobayashi 17110 An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory BIOPHYSICS AND COMPUTATIONAL BIOLOGY half-life of a fusion protein Johan Seijsing, Malin Lindborg, Ingmarie E5143 Relating influenza virus membrane fusion kinetics to Höidén-Guthenberg, Heiko Bönisch, Elin Guneriusson, stoichiometry of neutralizing antibodies at the Fredrik Y. Frejd, Lars Abrahmsén, Caroline Ekblad, single-particle level John Löfblom, Mathias Uhlén, and Torbjörn Gräslund Jason J. Otterstrom, Boerries Brandenburg, Martin H. Koldijk, Jarek Juraszek, Chan Tang, Samaneh Mashaghi, Ted Kwaks, Jaap Goudsmit, Ronald Vogels, Robert H. E. BIOCHEMISTRY Friesen, and Antoine M. van Oijen E5133 RecQ helicase and RecJ nuclease provide 17158 Orientation of aromatic residues in amyloid cores: complementary functions to resect DNA for Structural insights into prion fiber diversity homologous recombination Anna Reymer, Kendra K. Frederick, Sandra Rocha, Katsumi Morimatsu and Stephen C. Kowalczykowski Tamás Beke-Somfai, Catherine C. Kitts, Susan Lindquist, 17116 Combinatorial regulation of a signal-dependent and Bengt Nordén activator by phosphorylation and acetylation 17164 Fast high-resolution 3D total internal reflection Jose C. Paz, Sang-Ho Park, Naomi Phillips, Shigenobu fluorescence microscopy by incidence angle scanning Matsumura, Wen-Wei Tsai, Lawryn Kasper, Paul K. Brindle, and azimuthal averaging Guangtao Zhang, Ming-Ming Zhou, Peter E. Wright, Jérôme Boulanger, Charles Gueudry, Daniel Münch, and Marc Montminy Bertrand Cinquin, Perrine Paul-Gilloteaux, Sabine Bardin, 17122 Goniometer-based femtosecond crystallography with Christophe Guérin, Fabrice Senger, Laurent Blanchoin, X-ray free electron lasers and Jean Salamero Aina E. Cohen, S. Michael Soltis, Ana González, Laura Aguila, Roberto Alonso-Mori, Christopher O. Barnes, 17170 Global structural changes of an ion channel during its Elizabeth L. Baxter, Winnie Brehmer, Aaron S. Brewster, gating are followed by ion mobility mass spectrometry Axel T. Brunger, Guillermo Calero, Joseph F. Chang, Albert Konijnenberg, Duygu Yilmaz, Helgi I. Ingólfsson, Anna Dimitrova, Siewert J. Marrink, Zhuolun Li, Catherine Matthieu Chollet, Paul Ehrensberger, Thomas L. Eriksson,  Yiping Feng, Johan Hattne, Britt Hedman, Michael Vénien-Bryan, Frank Sobott, and Armagan Koçer Hollenbeck, James M. Holton, Stephen Keable, Brian K. 17176 Fibroblasts probe substrate rigidity with filopodia Kobilka, Elena G. Kovaleva, Andrew C. Kruse, Henrik T. extensions before occupying an area Lemke, Guowu Lin, Artem Y. Lyubimov, Aashish Manglik, Stephanie Wong, Wei-Hui Guo, and Yu-Li Wang Irimpan I. Mathews, Scott E. McPhillips, Silke Nelson, John W. Peters, Nicholas K. Sauter, Clyde A. Smith, 17182 Structures of protective antibodies reveal sites of Jinhu Song, Hilary P. Stevenson, Yingssu Tsai, Monarin vulnerability on Ebola virus Uervirojnangkoorn, Vladimir Vinetsky, Soichi Wakatsuki, Charles D. Murin, Marnie L. Fusco, Zachary A. William I. Weis, Oleg A. Zadvornyy, Oliver B. Zeldin, Bornholdt, Xiangguo Qiu, Gene G. Olinger, Larry Diling Zhu, and Keith O. Hodgson Zeitlin, Gary P. Kobinger, Andrew B. Ward, See Commentary on page 16986 and Erica Ollmann Saphire

PNAS u December 2, 2014 u vol. 111 u no. 48 u v Downloaded by guest on October 2, 2021 CELL BIOLOGY E5159 Synaptonemal complex extension from clustered 16995 Analysis of clock-regulated genes in Neurospora telomeres mediates full-length chromosome pairing reveals widespread posttranscriptional control of in Schmidtea mediterranea metabolic potential Youbin Xiang, Danny E. Miller, Eric J. Ross, Alejandro Jennifer M. Hurley, Arko Dasgupta, Jillian M. Emerson, Sánchez Alvarado, and R. Scott Hawley Xiaoying Zhou, Carol S. Ringelberg, Nicole Knabe, 17003 Circular permutation of a synthetic eukaryotic Anna M. Lipzen, Erika A. Lindquist, Christopher G. chromosome with the telomerator Daum, Kerrie W. Barry, Igor V. Grigoriev, Kristina M. Leslie A. Mitchell and Jef D. Boeke Smith, James E. Galagan, Deborah Bell-Pedersen, Michael Freitag, Chao Cheng, Jennifer J. Loros, 17224 Comparison of the transcriptional landscapes between and Jay C. Dunlap human and mouse tissues Shin Lin, Yiing Lin, Joseph R. Nery, Mark A. Urich, 17188 Inhibition of tumor cell proliferation and motility Alessandra Breschi, Carrie A. Davis, Alexander Dobin, by fibroblasts is both contact and soluble Christopher Zaleski, Michael A. Beer, William C. Chapman, factor dependent Thomas R. Gingeras, Joseph R. Ecker, and Michael P. Snyder Twana Alkasalias, Emilie Flaberg, Vladimir Kashuba, Andrey Alexeyenko, Tatiana Pavlova, Andrii Savchenko, 17230 Comparative analysis of the domestic cat genome Laszlo Szekely, George Klein, and Hayrettin Guven reveals genetic signatures underlying feline biology and domestication Michael J. Montague, Gang Li, Barbara Gandolfi, Razib DEVELOPMENTAL BIOLOGY Khan, Bronwen L. Aken, Steven M. J. Searle, Patrick Minx, 17194 Neural precursor-specific expression of multiple LaDeana W. Hillier, Daniel C. Koboldt, Brian W. Davis, Drosophila genes is driven by dual enhancer Carlos A. Driscoll, Christina S. Barr, Kevin Blackistone, Javier modules with overlapping function Quilez, Belen Lorente-Galdos, Tomas Marques-Bonet, Steven W. Miller, Mark Rebeiz, Jenny E. Atanasov, Can Alkan, Gregg W. C. Thomas, Matthew W. Hahn, Marilyn ’ and James W. Posakony Menotti-Raymond, Stephen J. O Brien, Richard K. Wilson, Leslie A. Lyons, William J. Murphy, and Wesley C. Warren

ENVIRONMENTAL SCIENCES 17236 High-throughput optical quantification of mechanosensory habituation reveals neurons 17200 The commonly used antimicrobial additive triclosan is encoding memory in Caenorhabditis elegans a liver tumor promoter Takuma Sugi, Yasuko Ohtani, Yuta Kumiya, Ryuji Mei-Fei Yueh, Koji Taniguchi, Shujuan Chen, Igarashi, and Masahiro Shirakawa Ronald M. Evans, Bruce D. Hammock, Michael Karin, and Robert H. Tukey IMMUNOLOGY AND INFLAMMATION E5169 Basophil-mediated protection against gastrointestinal EVOLUTION helminths requires IgE-induced cytokine secretion 17093 Static network structure can stabilize Christian Schwartz, Adriana Turqueti-Neves, Susanne human cooperation Hartmann, Philipp Yu, Falk Nimmerjahn, David G. Rand, Martin A. Nowak, James H. Fowler, and David Voehringer and Nicholas A. Christakis 17242 APE1 is dispensable for S-region cleavage but required 17206 Reducing the genetic code induces massive for its repair in class switch recombination rearrangement of the proteome Jianliang Xu, Afzal Husain, Wenjun Hu, Tasuku Honjo, Patrick O’Donoghue, Laure Prat, Martin Kucklick, and Maki Kobayashi Johannes G. Schäfer, Katharina Riedel, Jesse Rinehart, 17248 Optimal T-cell receptor affinity for inducing Dieter Söll, and Ilka U. Heinemann autoimmunity 17212 Termite queens close the sperm gates of eggs to switch Sabrina Koehli, Dieter Naeher, Virginie Galati-Fournier, from sexual to asexual reproduction Dietmar Zehn, and Ed Palmer Toshihisa Yashiro and Kenji Matsuura 17254 Caspase-1 autoproteolysis is differentially required 17218 New insight into the evolution of the vertebrate for NLRP1b and NLRP3 inflammasome function respiratory system and the discovery of unidirectional Baptiste Guey, Mélanie Bodnar, Serge N. Manié, airflow in iguana lungs Aubry Tardivel, and Virginie Petrilli Robert L. Cieri, Brent A. Craven, Emma R. Schachner, and C. G. Farmer MEDICAL SCIENCES E5178 Tubulin hyperacetylation is adaptive in cardiac GENETICS proteotoxicity by promoting autophagy Patrick M. McLendon, Bradley S. Ferguson, Hanna E5149 Simultaneous sequencing of oxidized methylcytosines Osinska, Md. Shenuarin Bhuiyan, Jeanne James, produced by TET/JBP dioxygenases in Timothy A. McKinsey, and Jeffrey Robbins Coprinopsis cinerea Lukas Chavez, Yun Huang, Khai Luong, Suneet E5187 Disruption of Lrp4 function by genetic deletion or Agarwal, Lakshminarayan M. Iyer, William A. Pastor, pharmacological blockade increases bone mass Virginia K. Hench, Sylvia A. Frazier-Bowers, Evgenia and serum sclerostin levels Korol, Shuo Liu, Mamta Tahiliani, Yinsheng Wang, Ming-Kang Chang, Ina Kramer, Thomas Huber, Tyson A. Clark, Jonas Korlach, Patricia J. Pukkila, Bernd Kinzel, Sabine Guth-Gundel, Olivier Leupin, L. Aravind, and Anjana Rao and Michaela Kneissel

vi u www.pnas.org Downloaded by guest on October 2, 2021 17260 Agonists of growth hormone-releasing hormone PHYSIOLOGY stimulate self-renewal of cardiac stem cells and 17302 Impact of circadian misalignment on energy metabolism promote their survival during simulated nightshift work Victoria Florea, Sonia S. Majid, Rosemeire M. Andrew W. McHill, Edward L. Melanson, Janine Higgins, Kanashiro-Takeuchi, Ren-Zhi Cai, Norman L. Elizabeth Connick, Thomas M. Moehlman, Ellen R. Block, Andrew V. Schally, Joshua M. Hare, Stothard, and Kenneth P. Wright Jr. and Claudia O. Rodrigues 17308 Syndecan 4 is required for endothelial alignment in flow 17266 Ovarian cancer stem cells express ROR1, which can be and atheroprotective signaling – targeted for anti cancer-stem-cell therapy Nicolas Baeyens, Mary Jo Mulligan-Kehoe, Federico Corti, Suping Zhang, Bing Cui, Hsien Lai, Grace Liu, Emanuela M. David D. Simon, Tyler D. Ross, John M. Rhodes, Thomas Z. Ghia, George F. Widhopf II, Zhuhong Zhang, Christina C. N. Wang, Cecile O. Mejean, Michael Simons, Jay Humphrey, Wu, Liguang Chen, Rongrong Wu, Richard Schwab, and Martin A. Schwartz Dennis A. Carson, and Thomas J. Kipps

17272 VEGF-B selectively regenerates injured peripheral PSYCHOLOGICAL AND COGNITIVE SCIENCES neurons and restores sensory and trophic functions 17066 People search for meaning when they approach Victor H. Guaiquil, Zan Pan, Natalia Karagianni, Shima a new decade in chronological age Fukuoka, Gemstonn Alegre, and Mark I. Rosenblatt Adam L. Alter and Hal E. Hershfield 17314 Mapping the unconscious maintenance of a lost MICROBIOLOGY first language E5196 Complex two-component signaling regulates the Lara J. Pierce, Denise Klein, Jen-Kai Chen, general stress response in Alphaproteobacteria Audrey Delcenserie, and Fred Genesee Andreas Kaczmarczyk, Ramon Hochstrasser, Julia A. Vorholt, and Anne Francez-Charlot 17320 Harm to others outweighs harm to self in moral decision making E5205 Cytoplasmic HIV-1 RNA is mainly transported by Molly J. Crockett, Zeb Kurth-Nelson, Jenifer Z. Siegel, diffusion in the presence or absence of Gag protein Peter Dayan, and Raymond J. Dolan Jianbo Chen, David Grunwald, Luca Sardo, Andrea Galli, Sergey Plisov, Olga A. Nikolaitchik, De Chen, Stephen 17326 Reward eliminates retrieval-induced forgetting Lockett, Daniel R. Larson, Vinay K. Pathak, Hisato Imai, Dongho Kim, Yuka Sasaki, and Takeo Watanabe and Wei-Shau Hu SUSTAINABILITY SCIENCE 17278 Densovirus associated with sea-star wasting disease and mass mortality E5224 Amazonian landscapes and the bias in field studies Ian Hewson, Jason B. Button, Brent M. Gudenkauf, of forest structure and biomass Benjamin Miner, Alisa L. Newton, Joseph K. Gaydos, Janna David C. Marvin, Gregory P. Asner, David E. Knapp, Wynne, Cathy L. Groves, Gordon Hendler, Michael Murray, Christopher B. Anderson, Roberta E. Martin, Steven Fradkin, Mya Breitbart, Elizabeth Fahsbender, Felipe Sinca, and Raul Tupayachi Kevin D. Lafferty, A. Marm Kilpatrick, C. Melissa Miner, Peter Raimondi, Lesanna Lahner, Carolyn S. Friedman, SYSTEMS BIOLOGY Stephen Daniels, Martin Haulena, Jeffrey Marliave, Colleen A. Burge, Morgan E. Eisenlord, and C. Drew Harvell 17330 Noise decomposition of intracellular biochemical signaling networks using nonequivalent reporters 17284 Global discovery of colonization determinants in the Alex Rhee, Raymond Cheong, and Andre Levchenko squid symbiont Vibrio fischeri John F. Brooks II, Mattias C. Gyllborg, David C. Cronin, Sarah J. Quillin, Celeste A. Mallama, Randi Foxall, Cheryl Whistler, Andrew L. Goodman, CORRECTIONS and Mark J. Mandel MICROBIOLOGY NEUROSCIENCE 17336 Patterned progression of bacterial populations in the premature infant gut E5214 The vertical occipital fasciculus: A century of controversy Patricio S. La Rosa, Barbara B. Warner, Yanjiao Zhou, resolved by in vivo measurements George M. Weinstock, Erica Sodergren, Carla M. Jason D. Yeatman, Kevin S. Weiner, Franco Pestilli, Hall-Moore, Harold J. Stevens, William E. Bennett, Jr., Ariel Rokem, Aviv Mezer, and Brian A. Wandell Nurmohammad Shaikh, Laura A. Linneman, Julie A. 17290 Topoisomerase 1 inhibition reversibly impairs Hoffmann, Aaron Hamvas, Elena Deych, Berkley A. synaptic function Shands, William D. Shannon, and Phillip I. Tarr Angela M. Mabb, Paul H. M. Kullmann, Margaret A. Twomey, Jayalakshmi Miriyala, Benjamin D. Philpot, PHYSIOLOGY and Mark J. Zylka − 17336 Dynamic modulation of ANO1/TMEM16A HCO3 2+ 17296 α2A adrenergic receptor promotes amyloidogenesis permeability by Ca /calmodulin through disrupting APP-SorLA interaction Jinsei Jung, Joo Hyun Nam, Hyun Woo Park, Uhtaek Oh, Yunjia Chen, Yin Peng, Pulin Che, Mary Gannon, Joo-Heon Yoon, and Min Goo Lee Yin Liu, Ling Li, Guojun Bu, Thomas van Groen, Kai Jiao, and Qin Wang ix Subscription Form

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