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December 2, 2014 u vol. 111 u no. 48 u 16975–17336 Cover image: Pictured is a vermillion sea star, Mediaster aequalis,inPorlierPass,British Columbia, that shows signs of sea-star wasting disease. As of June 2014, the disease had affected 20 species of sea stars from Alaska to Baja California, but its cause is unknown. Ian Hewson et al. surveyed sea-star populations and conducted laboratory infection studies. They found that sea-star wasting disease is likely caused by a virus and identified a densovirus as a potential infectious agent. See the article by Hewson et al. on pages 17278–17283. Image courtesy of Peter Luckham (www.divemaster.ca). From the Cover 17278 Potential cause of sea-star wasting disease 17075 Human ability to evaluate probabilities 17122 X-ray free crystallography 17140 DNA binding site recognition by regulatory proteins 17182 Ebola antibodies’ modes of action Contents COMMENTARIES 16982 Going viral and the fatal vulnerability of neurons from immunity, not from infection THIS WEEK IN PNAS Lawrence Steinman See companion article on page 16053 in issue 45 of volume 111 16975 In This Issue 16984 Fuzzy universality of probability judgment Valerie F. Reyna and Charles J. Brainerd See companion article on page 17075 INNER WORKINGS—An over-the-shoulder look at scientists at work 16986 Expanding the femtosecond crystallography toolkit Sol M. Gruner 16977 Inner Workings: Freeing the dinos within See companion article on page 17122 Stephen Ornes CORE CONCEPTS—A brief introduction to emerging topics in science PNAS PLUS 16978 Core Concept: Synthetic biology—change, accelerated 16988 Significance Statements Danielle Venton Brief statements written by the authors about the significance of their papers. RETROSPECTIVE PERSPECTIVE 16980 David T. Gibson: From biodegradation to biocatalysis Caroline S. Harwood and Rebecca E. Parales 16990 Evolutionary cell biology: Two origins, one objective Michael Lynch, Mark C. Field, Holly V. Goodson, Harmit S. Malik, José B. Pereira-Leal, David S. Free online through the PNAS open access option. Roos, Aaron P. Turkewitz, and Shelley Sazer PNAS u December 2, 2014 u vol. 111 u no. 48 u iii–vii Downloaded by guest on October 2, 2021 ENVIRONMENTAL SCIENCES INAUGURAL ARTICLES 17045 Rapid climate change did not cause population collapse at the end of the European Bronze Age 16995 Analysis of clock-regulated genes in Neurospora Ian Armit, Graeme T. Swindles, Katharina Becker, reveals widespread posttranscriptional control of Gill Plunkett, and Maarten Blaauw metabolic potential Jennifer M. Hurley, Arko Dasgupta, Jillian M. Emerson, Xiaoying Zhou, Carol S. Ringelberg, Nicole Knabe, PHYSICS Anna M. Lipzen, Erika A. Lindquist, Christopher G. 17050 Revealing an unusual transparent phase of superhard Daum, Kerrie W. Barry, Igor V. Grigoriev, Kristina M. iron tetraboride under high pressure Smith, James E. Galagan, Deborah Bell-Pedersen, Komsilp Kotmool, Thanayut Kaewmaraya, Sudip Michael Freitag, Chao Cheng, Jennifer J. Loros, Chakraborty, Jonas Anversa, Thiti Bovornratanaraks, and Jay C. Dunlap Wei Luo, Huiyang Gou, Paulo Cesar Piquini, 17003 Circular permutation of a synthetic eukaryotic Tae Won Kang, Ho-kwang Mao, and Rajeev Ahuja chromosome with the telomerator 17054 Force distribution affects vibrational properties Leslie A. Mitchell and Jef D. Boeke in hard-sphere glasses Eric DeGiuli, Edan Lerner, Carolina Brito, and Matthieu Wyart PHYSICAL SCIENCES APPLIED PHYSICAL SCIENCES SOCIAL SCIENCES 17011 Charging-free electrochemical system for harvesting low-grade thermal energy Yuan Yang, Seok Woo Lee, Hadi Ghasemi, James Loomis, ANTHROPOLOGY Xiaobo Li, Daniel Kraemer, Guangyuan Zheng, Yi Cui, 17045 Rapid climate change did not cause population collapse and Gang Chen at the end of the European Bronze Age 17017 Instability-induced pattern formation of photoactivated Ian Armit, Graeme T. Swindles, Katharina Becker, functional polymers Gill Plunkett, and Maarten Blaauw Henning Galinski, Antonio Ambrosio, Pasqualino 17060 New insights into Eastern Beringian mortuary behavior: Maddalena, Iwan Schenker, Ralph Spolenak, A terminal Pleistocene double infant burial at Upward and Federico Capasso Sun River Ben A. Potter, Joel D. Irish, Joshua D. Reuther, CHEMISTRY and Holly J. McKinney 17023 Graphene cover-promoted metal-catalyzed reactions Yunxi Yao, Qiang Fu, Y. Y. Zhang, Xuefei Weng, Huan Li, PSYCHOLOGICAL AND COGNITIVE SCIENCES Mingshu Chen, Li Jin, Aiyi Dong, Rentao Mu, Peng Jiang, 17066 People search for meaning when they approach Li Liu, Hendrik Bluhm, Zhi Liu, S. B. Zhang, and Xinhe Bao a new decade in chronological age 17158 Orientation of aromatic residues in amyloid cores: Adam L. Alter and Hal E. Hershfield Structural insights into prion fiber diversity 17071 Rethinking natural altruism: Simple reciprocal Anna Reymer, Kendra K. Frederick, Sandra Rocha, interactions trigger children’s benevolence Tamás Beke-Somfai, Catherine C. Kitts, Susan Lindquist, Rodolfo Cortes Barragan and Carol S. Dweck and Bengt Nordén 17075 Probabilistic cognition in two indigenous Mayan groups EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Laura Fontanari, Michel Gonzalez, Giorgio E5123 Orbital apocenter is not a sufficient condition for Vallortigara, and Vittorio Girotto HST/STIS detection of Europa’s water vapor aurora See Commentary on page 16984 Lorenz Roth, Kurt D. Retherford, Joachim Saur, 17081 The association between discontinuing hormonal Darrell F. Strobel, Paul D. Feldman, Melissa A. contraceptives and wives’ marital satisfaction McGrath, and Francis Nimmo depends on husbands’ facial attractiveness 17029 Silicon isotopes in angrites and volatile loss V. Michelle Russell, James K. McNulty, Levi R. Baker, in planetesimals and Andrea L. Meltzer Emily A. Pringle, Frédéric Moynier, Paul S. Savage, 17087 Credit scores, cardiovascular disease risk, and James Badro, and Jean-Alix Barrat human capital 17033 Transition from geostrophic turbulence to inertia– Salomon Israel, Avshalom Caspi, Daniel W. Belsky, gravity waves in the atmospheric energy spectrum HonaLee Harrington, Sean Hogan, Renate Houts, Jörn Callies, Raffaele Ferrari, and Oliver Bühler Sandhya Ramrakha, Seth Sanders, Richie Poulton, and Terrie E. Moffitt 17039 Earthquake and tsunami forecasts: Relation of slow slip events to subsequent earthquake rupture 17314 Mapping the unconscious maintenance of a lost Timothy H. Dixon, Yan Jiang, Rocco Malservisi, first language Robert McCaffrey, Nicholas Voss, Marino Protti, Lara J. Pierce, Denise Klein, Jen-Kai Chen, and Victor Gonzalez Audrey Delcenserie, and Fred Genesee iv u www.pnas.org Downloaded by guest on October 2, 2021 17320 Harm to others outweighs harm to self in moral 17128 Structure of the meningococcal vaccine antigen NadA decision making and epitope mapping of a bactericidal antibody Molly J. Crockett, Zeb Kurth-Nelson, Jenifer Z. Siegel, Enrico Malito, Marco Biancucci, Agnese Faleri, Ilaria Peter Dayan, and Raymond J. Dolan Ferlenghi, Maria Scarselli, Giulietta Maruggi, Paola Lo Surdo, Daniele Veggi, Alessia Liguori, Laura Santini, Isabella Bertoldi, Roberto Petracca, Sara Marchi, Giacomo SOCIAL SCIENCES Romagnoli, Elena Cartocci, Irene Vercellino, Silvana Savino, 17093 Static network structure can stabilize Glen Spraggon, Nathalie Norais, Mariagrazia Pizza, Rino human cooperation Rappuoli, Vega Masignani, and Matthew James Bottomley David G. Rand, Martin A. Nowak, James H. Fowler, 17134 Structural model of an mRNA in complex with and Nicholas A. Christakis the bacterial chaperone Hfq Yi Peng, Joseph E. Curtis, Xianyang Fang, and Sarah A. Woodson − BIOLOGICAL SCIENCES 17140 Protein DNA binding in the absence of specific base-pair recognition Ariel Afek, Joshua L. Schipper, John Horton, APPLIED BIOLOGICAL SCIENCES Raluca Gordân, and David B. Lukatsky 17099 Aptamer photoregulation in vivo 17146 Activity-regulating structural changes and Lele Li, Rong Tong, Hunghao Chu, Weiping Wang, autoantibody epitopes in transglutaminase 2 Robert Langer, and Daniel S. Kohane assessed by hydrogen/deuterium exchange 17104 NanoFlares for the detection, isolation, and culture of Rasmus Iversen, Simon Mysling, Kathrin Hnida, live tumor cells from human blood Thomas J. D. Jørgensen, and Ludvig M. Sollid Tiffany L. Halo, Kaylin M. McMahon, Nicholas L. Angeloni, 17152 Natural low-molecular mass organic compounds with Yilin Xu, Wei Wang, Alyssa B. Chinen, Dmitry Malin, oxidase activity as organocatalysts Elena Strekalova, Vincent L. Cryns, Chonghui Cheng, Tatsuya Nishiyama, Yoshiteru Hashimoto, Hitoshi Kusakabe, Chad A. Mirkin, and C. Shad Thaxton Takuto Kumano, and Michihiko Kobayashi 17110 An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory BIOPHYSICS AND COMPUTATIONAL BIOLOGY half-life of a fusion protein Johan Seijsing, Malin Lindborg, Ingmarie E5143 Relating influenza virus membrane fusion kinetics to Höidén-Guthenberg, Heiko Bönisch, Elin Guneriusson, stoichiometry of neutralizing antibodies at the Fredrik Y. Frejd, Lars Abrahmsén, Caroline Ekblad, single-particle level John Löfblom, Mathias Uhlén, and Torbjörn Gräslund Jason J. Otterstrom, Boerries Brandenburg, Martin H. Koldijk, Jarek Juraszek, Chan Tang, Samaneh Mashaghi, Ted Kwaks, Jaap Goudsmit, Ronald Vogels, Robert H. E. BIOCHEMISTRY Friesen, and Antoine M. van Oijen E5133 RecQ helicase and RecJ nuclease provide 17158 Orientation of aromatic residues in amyloid cores: complementary functions to resect DNA for Structural insights into prion fiber diversity homologous recombination Anna Reymer, Kendra K. Frederick,