Rethinking Mental Disorders

Home , Doreen Cantrell, Edvard Moser, Lucy Shapiro, Peter Carmeliet, Salvador Moncada, Susan Lindquist

SUMMER 2011

encounters Newsletter of the European Molecular Biology Organization

Rethinking mental disorders

Nikolas Rose from the BIOS Centre at the London School of the world – suggests that 25 per cent of adults not currently receiving Economics talks about how a mental disorder is defi ned, how psychiatric treatment could be diagnosed for mental disorders at any psychiatry is infl uenced by neurosciences and the controversial time; and the WHO predicts that by the year 2020 depression will be revision of the manual of psychiatric diagnosis. Rose is keynote one of the leading causes of ill health. speaker at Making sense of mental illness: biology, medicine and society, the EMBO | EMBL Science & Society Conference to be held What caused such an explosion? in Heidelberg from 4–5 November. This is a matter of dispute. Is there genuinely so much mental ill health? Are the fi gures a result of fl awed research methods? Are they a Nikolas, how big is the impact of mental health issues on consequence of increased recognition fuelled by awareness campaigns, today’s society? some funded by those that stand to gain? Or does this have something There is an increasing belief among professionals and lay persons to do with the diagnostic procedures themselves? Even minor mental that many troubles of everyday life, as well as more serious problems, troubles now come within the scope of psychiatric diagnostic manu- result from mental disorders. Policy makers are particularly concerned als. The American Psychiatric Association – currently revising the that mental illness not only produces distress for individuals and their Diagnostic and Statistical Manual of Mental Disorders (see info box) families, but also leads to the loss of many working days and is costly – is coming to the view that one should move away from categorical for social and health services. distinctions to a dimensional approach. Some say that this might lead to even more people being ‘suitable cases for treatment’. Why do you think this topic has recently received so much attention? Partly this is a result of awareness campaigns by many organizations; If such a huge percentage of the HIGHLIGHTS and partly because increasingly people are willing to speak out about population is affected then perhaps their experience of mental ill health. There is also the growing aware- this is simply an inherent part of ness of the problems of dementia due to an aging population. Also, our lives. Interview with almost all of us have experienced our parents, relatives or close friends Many do make that argument, and Carol V. Robinson – suffering from mild, moderate or even severe psychiatric conditions. this is one of the interesting areas of 2011 FEBS | EMBO Women 5 our conference. In my introductory in Science Award winner Can we speak of a global epidemic of mental disorder? talk I’ll try to explain the dilemma: The statistics certainly paint an alarming picture. The epidemiology (continued on next page) ➞ ➞ both in the US and in Europe – the wealthiest and healthiest regions of Things to do in Vienna – polling the local EMBO community 7/8 INFO BOX | Revision of psychiatric diagnostic manual First published in 1952, the law breakers may be confi ned in additions to the fi fth edition – Diagnostic and Statistical Manual psychiatric institutions instead of the fi rst complete revision since Ice and anther – of Mental Disorders (DSM) is at the being imprisoned and how much 1994 – will lead to an increase in best of The EMBO Journal heart of mental health research, insurance companies pay for the number of people being diag- cover contest 9 planning, policy and treatment treatment. Over the last decades, nosed with mental disorders and in the US and in varying degrees more mental disorders have treated, sometimes with unneces- around the world. It is a power- been included in the manual, sary drugs that have troublesome Biocenter Finland – ful tool that determines who gets although some have also been side effects. The new edition is developing cost-effi cient diagnosed as mentally ill, who removed, most notably homosex- due out in May 2013. services at the national receives what kind of drugs, which uality. Critics say that proposed 11 level

Rethinking mental disorders (cont.) Interview with Nikolas Rose where should one draw the the advances at the neurobio- boundaries between a condi- logical level and our capacity to tion that is appropriate for intervene therapeutically in the diagnosis and treatment clinic. And as for diagnosis, it and a condition that is part remains the case that there are of everyday life that people no generally accepted and vali- need to accept? Where does dated biomarkers for any psychi- childhood bad behavior end atric condition that can be used and ADHD begin? Normal clinically. sadness end and depression begin? Age-related memory Which fi eld of neuroscience do loss end and Mild Cognitive you think will receive particular Impairment begin? Many indi- attention in the coming years? vidual and social consequenc- 12th joint One major issue – not just in EMBO | EMBL conference es fl ow from the way we draw on Science & Society advanced industrial societies these lines. 4 – 5 November 2011 but also in countries such as EMBL Advanced Training Centre | Heidelberg | Germany China or India – is the question Which therapies for mental Speakers, chairs, of dementia and Alzheimer’s disorder have made the biggest & panellists: disease. Obviously as the popu- Friday | 4 November Dusan Bartsch DE progress in the last decades? Nikolas Rose lation ages, the incidence of I think one can detect a grow- Keynote speaker Mathias Berger DE these disorders increases. The Donna Franceschild UK ing disenchantment with Topics extent to which we are able to Impact and defi nition of Cornelius Gross IT psychopharmaceuticals as the mental illness Tim Kendall UK characterize these disorders at universal therapy of choice. The biology of mental David J. Kupfer US a neurobiological level in living illness In the eighties and nineties Simon Lovestone UK individuals – that is to differen- many people began to argue Saturday | 5 November Helen S. Mayberg US tiate between early Alzheimer’s Topics Andreas Meyer-Lindenberg DE that depressive conditions STUDENTS and normal aging – is a matter 04.11.2011 20 Euro Pills, sofas and surgery – Geraint Rees UK 1 1

0 05.11.2011

20 20 2 ways of treatment . were very common in soci- 1. REGISTRATION FEE 1 Nikolas Rose UK of dispute. There are some who 40 Euro Society and mental 04.11.2011 05.11.2011 Steven Rose UK ety and needed to be treat- illness argue that increasingly that ed. That went hand in hand Wulf Rössler CH is possible. Simon Lovestone Sir Michael Rutter UK with the development of the speaking at the conference is one Luca Santarelli CH HIGH SCHOOL new anti-depressants called STUDENTS Organizing committee of those. 05.11.2011 Joseph A. Sergeant NL

free entrance Dusan Bartsch Central Institute of Mental 04.11.2011 Health | Mannheim | DE Selective Serotonin Re-uptake Hans-Ullrich Wittchen DE Cornelius Gross European Molecular Biology Laboratory | Monterotondo | IT Andreas Meyer-Lindenberg Central Institute Inhibitors (SSRIs), of which of Mental Health | Mannheim | DE What is your personal highlight Nikolas Rose BIOS | London School of the best known was Prozac. Economics | UK of the upcoming conference? Alessandra Bendiscioli EMBO Science & Society Programme The hypothesis of a neural Holger Breithaupt EMBO reports I’m very pleased that we have Gerlind Wallon EMBO Deputy Director basis of depression and the Contact Halldor Stefansson EMBL Science & Society a talk describing the patients Programme EMBO European Molecular mechanisms of these drugs Biology Organization perspective from Donna Science & Society Programme Meyerhofstr. 1 was almost certainly incorrect. 69117 Heidelberg, Germany Franceschild, who is a writer by S. Krahl © 2011 EMBO | Poster Tel. +49 6221 8891 119 www.embo.org/ Further, the argument about [email protected] science-society-conference-2011 and dramatist for TV and radio their selectivity for depression and has been active in patients’ was soon abandoned, as they movements in psychiatry. In the became prescribed for anxiety, social anxiety of mental processes, but would identify the past, the last persons who were listened to and other disorders. Currently, we see increas- specifi c neural bases of psychiatric problems. about the value of their treatment were the ing interest in methods like deep brain stimu- Some hoped that each symptom had a precise users themselves. I think the emergence of the lation, transcranial magnetic intervention and neurobiological basis that could be identifi ed patient’s voice, the recognition that they have other electrical and magnetic techniques that to aid precise diagnosis and guide a therapy the right to a say in how psychiatry devel- go straight to the brain. that would hit those symptoms without all ops, is applied and evaluated, is as major an the adverse effects associated with the older advance for psychiatry as developments in Did the rapid development of the neuro- psychiatric drugs. That hope spawned a great neuroscience. sciences in the nineties help to diagnose and investment in the development of drugs for treat psychiatric conditions more precisely? psychotic disorders. This was certainly the hope of those who The jury is still out whether or not this will be have supported the spectacular recent growth a successful pathway to follow in the medi- of neuroscientifi c research. That a growing um to long term. It has not proved particu- ‘molecular’ understanding of brain mecha- larly successful in the short term. There nisms wouldn’t just cast light on the nature is still a very big translational gap between 3 EMBO Gold Medalist for 2011 Groundbreaking research on DNA repair, genome integrity and cancer

Simon Boulton’s research highlights required for checkpoint-kinase signalling include: (ATR) in response to DNA damage and ➔ Discovering the gene RTEL1 as an anti- establishing that DNA repair defects of recombinase that impacts on genome sta- Fanconi Anaemia cells can be suppressed bility and cancer and counteracts toxic by blocking error prone repair by non- recombination, which is also required in homologous end joining. meiosis to execute non-crossover repair. For more on this year’s award winner ➔ Discovering the PBZ motif and estab- see the press release at: lishing that ALC1 (Amplifi ed in Liver www.embo.org/news/press-releases- Cancer 1) is a poly(ADP-ribose)-activated 2011/embo-gold-medal-2011-awarded- chromatin-remodelling enzyme required to-simon-boulton.html for DNA repair. Poly(ADP-ribosyl)ation (PAR) is a post-translational modifi cation of proteins that play an im- © Cancer Research UK | London Research Institute UK | London Research © Cancer Research portant role in mediating protein interactions and the ◗ Simon Boulton of Cancer Research UK’s recruitment of specifi c London Research Institute, is the win- protein targets. These ner of the 2011 EMBO Gold Medal. The results provided new 38-year-old received the award in recog- insights into the mech- nition of his groundbreaking research on anisms by which PAR DNA repair mechanisms. The election regulates DNA repair. committee was particularly impressed by his pioneering role in establishing the ➔ Discovering that the nematode worm, C. elegans, as a model Fanconi Anaemia proteins system to study genome instability. FANCM and FAAP24 are

Structure and Dynamics of

ABSTRACT 14SUBMISSION AUGUST Protein DEADLINE Networks REGISTRATION 1 SEPTEMBER DEADLINE EMBO | EMBL Symposium 13 –16 October 2011 | Heidelberg | Germany EMBL Advanced Training Centre

SPEAKERS Patrick Aloy François Nédélec Chris Bakal Garry Nolan

Philippe Bastiaens Lucas Pelkmans ORGANIZERS Martin Beck Natasa Przulj Anne-Claude Gavin John Briggs Aurelien Roux Marko Kaksonen Iain Cheeseman Philip Selenko Giulio Superti-Furga Suzanne Gaudet Jussi Taipale

Tom Kirchhausen Eva Wolf Additional speakers will be Tanja Kortemme Peter Wright selected from abstracts. Ben Lehner Marino Zerial www.embo-embl-symposia.org © 2011 EMBO|EMBL Symposia | Poster by U. Mackensen by U. | Poster © 2011 EMBO|EMBL Symposia

EMBO Events JULY 2011 – APRIL 2012

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Bioinformatics and Metagenomics: From the Intracellular RNA transport Epigenetics in context: From EMBL | EMBO Science & comparative genome analyses bench to data analysis and localized translation ecology to evolution Society Summer School FR-Paris, 27 June–9 July 2011 DE-Heidelberg, IT-Barga, 7–12 August 2011 ES-Sant Feliu de Guixols, The human animal: Scientifi c, 23–29 October 2011 18–23 September 2011 social and moral perspectives High-throughput methods Protein synthesis and DE-Heidelberg, for protein production and Protein–protein and protein– translational control Synthetic biology of antibiotic DE-Heidelberg, 7–11 September 1–6 August 2011 crystallization nucleic acid cross-linking and production mass spectrometry 2011 FR-Marseille, 4–13 July 2011 ES-Sant Feliu de Guixols, The EMBO Meeting 2011 – DE-Göttingen, Lymphocyte signalling: 2–7 October 2011 Advancing the life sciences Marine animal models in 23–29 October 2011 Translating membrane AT-Vienna, evolution and development EMBO | EMBL SYMPOSIA Imaging infection: From signals into differentiation 10–13 September 2011 SE-Fiskebäckskil, programmes Cancer genomics single molecules to animals EMBO Members’ Workshop 4–14 July 2011 IT-Pontignano (Siena), 10–14 DE-Heidelberg, ZA-Pretoria, DE-Heidelberg, September 2011 17–19 September 2011 Developmental neurobiology: 2–13 November 2011 26–28 October 2011 From worms to mammals Nuclear receptors: From Computational structural Structure and dynamics of EMBO | EMBL Science and UK-London, 8–22 July 2011 molecular mechanism to biology: From data to protein networks Society Conference structure to function health and disease Single-molecule DE-Heidelberg, Making sense of mental illness: UK-Hinxton, ES-Sitges (Barcelona), nanomanipulation and 13–16 October 2011 Biology, medicine & society 14–18 November 2011 16–20 September 2011 analysis of protein–DNA Immunology of DE-Heidelberg, Meiosis interactions Mass spectrometry and host – pathogen interactions 4–5 November 2011 FR-Paris, 10–24 July 2011 proteomics IT-Capaccio (Paestum), DE-Heidelberg, EMBO Molecular Medicine DK-Odense, 18–25 April 2012 17–21 September 2011 Multi-level modelling of 19–22 May 2012 Conference Ubiquitin and ubiquitin-like morphogenesis WORKSHOPS Molecular insights for modifi ers: From functional EMBO | FEBS UK-Norwich, 17–29 July 2011 innovative therapies 50 years of X-inactivation modules to systems biology LECTURE COURSES DE-Heidelberg, Structure, dynamics and research HR-Cavtat (Dubrovnik), Biomembrane dynamics: UK-Oxford, 20–24 July 2011 1–3 December 2011 function of biological 21–25 September 2011 From molecules to cells macromolecules by solution Exploring the logic of the cell Dynamic endosomes: FR–Cargese, 21–29 June 2011 NMR cycle Mechanisms controlling Actin-based motility: From DE-Garching, FR-Montpellier, endocytosis molecules to model organisms 29 July–5 August 2011 2–5 September 2011 GR-Kato Galatas (Crete), IT-Stresa (Lake Maggiore), 24–29 September 2011 Computational biology: Retinoids 2011 29 October–2 November 2011 Genomes, cells & systems FR-Illkirch, The assembly and function of EMBO GLOBAL EXCHANGE IS-Reykjavik, 6–13 August 2011 22–24 September 2011 neuronal circuits CH-Ascona, LECTURE COURSES Studying protein–protein Chromosome structure, 25–30 September 2011 Next generation sequencing interactions by advanced light damage and repair GR-Cape Sounio, 25–28 Host genetics control of for Africa microscopy and spectroscopy September 2011 infectious diseases KE-Nairobi, HU-Debrecen, FR-Paris, 28–30 September 5–10 September 2011 16–22 August 2011 Histone variants and genome 2011 regulation Logic of regulatory circuits Image processing for FR-Illkirch, 12–14 October 2011 Nuclear structure and TW-Taipei, 12–16 January 2012 cryo-electron microscopy dynamics Intracellular proteolysis and Introduction to synthetic UK-London, 30 August–9 FR-L’Isle sur la Sorgue, cancer biology September 2011 28 September–2 October 2011 ES-Valencia, AR-Buenos Aires, For more information and a Two-photon imaging of brain Centrosomes and spindle pole 26–28 October 2011 16–22 April 2012 list of all courses, workshops, circuits bodies Mechanisms of conferences and symposia DE-Munich, ES-Barcelona, 2–6 October EMBO | EMBL SYMPOSIA nucleocytoplasmic traffi cking please go to 3–10 September 2011 2011 IL-Ma’ale Hachamisha, Cancer genomics events.embo.org. 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“I was fortunate to go down my own research route”

in what directions? How do you think it would be seen now? I still get results It would probably be considered that you that surprise me were out of the fi eld for too long. On the even though I’ve other hand it is much easier to keep in been doing it for touch. In my time you would have had to go so long. to the lab every day to be part of the research team. Nowadays you could stay home for But wouldn’t that maternity leave and be able to log on and apply to any other talk to your team when your baby is asleep. research? I don’t think So has the perception of society towards it is quite so female scientists taking time out become true with other more negative? techniques. In I think it really has become more negative more established and it is often perceived that you are not a techniques I think serious scientist if you take this path. you can predict © University of Oxford | Department Chemistry © University to some extent How would you describe the spirit of female how something is researchers in the UK today? Chemistry professor Carol V. Robinson has going to behave, whereas the gas phase is been recognized for her pioneering work still a very new phase for studying very large Many of them say it is very hard to balance in the development of mass spectrometry complexes. You can’t always be sure how or things. I also see a lot of young women with this year’s FEBS | EMBO Women in if it is going to work. struggle with the pressures of papers, grants Science Award. Carol was the fi rst woman and families. I can understand what it is like. to become a professor of Chemistry in Your scientifi c career took off quite When my children were little, I worked very Cambridge in 2001, and her early career late after you left school at sixteen. hard early in the morning and then again was marked by an eight-year break to raise Why did you leave at such a young age? when they had gone to bed. It was quite a her three children. In EMBOencounters she My school wasn’t particularly academic. long day. talks about her unusual career path and Pupils were asked to learn shorthand and today’s spirit of female researchers in the typing, needlework and cookery. Further What kept you on your toes? UK. education was not really promoted and I I wanted to know the answers to questions wasn’t encouraged to go to university. So I was working on at the time. And I was Carol, the award committee praised you as I became a research technician in a mass determined to succeed because I had such a “the world’s leading researcher in a male- spectrometry lab. I liked the challenge from long time out. At the age of 38 I was a high- dominated fi eld”. Why do you think other the very start. risk person for people to employ. I wanted women shy away from mass spectrometry? my colleagues to think they had not made Certainly more women work in mass From research technician to postdoc a mistake. When I got the Royal Society spectrometry nowadays than when I was is a long way... Fellowship, I was fortunate because I could I was fortunate that my supervisors starting my career. I used to be the only show my independence and go down my woman at national and international supported me through my part-time own research route. meetings in the seventies. But today it is education. After my day’s work I attended much more equal – particularly since mass college for one day and two evenings a week. How do you support young parents in spectrometry is applied more and more to It was tiring but after seven years I got a your lab? the biological sciences. degree in chemistry and went to Cambridge Generally I have quite a lot of young parents to do my PhD. working for me. They may not be in all the What fascinates you about time, especially if the child is sick, but they this fi eld of research? Then you took an eight-year career break to work very hard. I’ve never been obsessed Initially it was the technical aspect that raise your children. How was your decision I really liked. Back then, it was quite perceived by your colleagues and friends at with people’s working hours. It is one of the challenging to get spectra. Most days the that time? few careers where you can be very fl exible. instrument would break down, lose vacuum I think some were envious because I really or the fi lament would break. Today it is enjoyed spending time with my children. What job would you be in today if your easier to get spectra, but I fi nd the results Other people said that I would be really academic career had not taken off? more interesting, particularly since it is still bored. A few colleagues warned me that I I always said that if I didn’t succeed in what often unpredictable. You rarely know what would not be able to return. So I was very I was doing I would make jewellery. Not you are going to see when you put a very happy when I found someone who agreed to expensive jewellery, but fashion jewellery. I large complex into a mass spectrometer. Is it take me back. All in all, I enjoyed that break used to do it as a hobby. Thankfully I haven’t going to hold together or fall apart and if so, and look back on it as a very special time. had to fall back on that option just yet!

EMBO Scientiﬁ c Publications | Editor Picks In each issue of EMBOencounters, the editors of The EMBO Journal, EMBO reports, Molecular Systems Biology and EMBO Molecular Medicine highlight particularly interesting papers.

THE EMBO EMBO Molecular JOURNAL Medicine

RESEARCH ARTICLES SCIENTIFIC REPORTS RESEARCH ARTICLES RESEARCH ARTICLES

Modulating F-actin organization MiD49 and MiD51, new RNAi screen of Salmonella invasion ZNF703 is a common Luminal induces organ growth by affecting components of the mitochondrial shows role of COPI in membrane B breast cancer oncogene that the Hippo pathway fi ssion machinery targeting of cholesterol and Cdc42. differentially regulates luminal Sansores-Garcia L, Bossuyt W, Palmer CS, Osellame LD, Laine D, Misselwitz B, Dilling S, Vonaesch P, and basal progenitors in human Wada K-I, Yonemura S, Tao C, Koutsopoulos OS, Frazier AE, Sacher R, Snijder B, Schlumberger M, mammary epithelium. Sasaki H and Halder G Ryan MT Rout S, Stark M, von Mering C, Holland DG, Burleigh A, Git A, doi:10.1038/emboj.2011.157 doi:10.1038/embor.2011.54 Pelkmans L, Hardt WD. Goldgraben MA, Perez-Mancera PA, Mol Syst Biol. 7:474 Chin SF, Hurtado A, Bruna A, Galactose-modifi ed iNKT cell Ataxin-1 and Brother of ataxin-1 Ali HR, Greenwood W, Dunning MJ, agonists stabilized by an induced are components of the Notch Dynamic transcriptome analysis Samarajiwa S, Menon S, Rueda OM, fi t of CD1d prevent tumour signalling pathway measures rates of mRNA synthesis Lynch AG, McKinney S, Ellis IO, metastasis Tong X, Gui H, Jin F, Heck BW, Lin P, and decay in yeast. Eaves CJ, Carroll JS, Curtis C, Aspeslagh S, Li Y, Dawen Yu E, Ma J, Fondell JD, Tsai CC Miller C, Schwalb B, Maier K, Schulz Aparicio S, Caldas C. Pauwels N, Trappeniers M, Girardi E, doi:10.1038/embor.2011.49 D, Dümcke S, Zacher B, Mayer A, doi: 10.1002/emmm.201100122.. Decruy T, Van Beneden K, Sydow J, Marcinowski L, Dölken L, Venken K, Drennan M, Leybaert REVIEWS Martin DE, Tresch A, Cramer P. ZNF703 gene amplifi cation at L, Wang J, Franck RW, Van Tracking adult stem cells Mol Syst Biol. 7:458. 8p12 specifi es luminal B breast Calenbergh S, Zajonc DM and cancer. Snippert HJ, Clevers H Self-organized partitioning of Elewaut D doi:10.1038/embor.2010.216 Sircoulomb F, Nicolas N, Ferrari A, doi:10.1038/emboj.2011.145 dynamically localized proteins in Finetti P, Bekhouche I, Rousselet E, Regenerating the epigenome bacterial cell division. Lonigro A, Adélaïde J, Baudelet E, Histone variant macroH2A Barrero MJ, Belmonte JCI Di Ventura B, Sourjik V. Esteyriès S, Wicinski J, Audebert S, confers resistance to nuclear doi:10.1038/embor.2011.10 Mol Syst Biol. 7:457 Charafe-Jauffret E, Jacquemier J, reprogramming Lopez M, Borg JP, Sotiriou C, Pasque V, Gillich A, Garrett N and SCIENCE & SOCIETY Analysis of multiple compound- protein interactions reveals novel Popovici C, Bertucci F, Birnbaum D, Gurdon JB Chaffanet M, Ginestier C. doi:10.1038/emboj.2011.144 Exorcising ghostwriting… bioactive molecules. Bosch X Yabuuchi H, Niijima S, Takematsu H, doi: 10.1002/emmm.201100121 Extracellular phosphorylation of doi:10.1038/embor.2011.87 Ida T, Hirokawa T, Hara T, Ogawa T, Staphylococcus aureus phenotype the amyloid β-peptide promotes Minowa Y, Tsujimoto G, Okuno Y. Reading the tea leaves of Congress switching: an effective bacterial formation of toxic aggregates Mol Syst Biol. 7:472 strategy to escape host immune during the pathogenesis of Suran M doi:10.1038/embor.2011.59 REVIEWS response and establish a chronic Alzheimer’s disease infection. Kumar S, Rezaei-Ghaleh N, Terwel D, Social interaction in synthetic and Tuchscherr L, Medina E, Hussain M, Thal DR, Richard M, Hoch M, natural microbial communities. Völker W, Heitmann V, Niemann S, McDonald JM, Wüllner U, Glebov K, Xavier JB. Holzinger D, Roth J, Proctor RA, Heneka MT, Walsh DM, Mol Syst Biol. 7:483. Becker K, Peters G, Löffl er B. Zweckstetter M and Walter J doi: 10.1002/emmm.20100011 doi:10.1038/emboj.2011.138 Determinants of translation effi ciency and accuracy. A CAG repeat polymorphism of The CW domain, a new histone Gingold H, Pilpel Y. KCNN3 predicts SK3 channel recognition module in chromatin Mol Syst Biol. 7:481. function and cognitive proteins performance in schizophrenia. Hoppmann V, Thorstensen T, A comprehensive map of the mTOR Grube S, Gerchen MF, Adamcio B, Kristiansen PE, Veiseth SV, Rahman signaling network. Pardo LA, Martin S, Malzahn D, MA, Finne K, Aalen RB and Aasland R Caron E, Ghosh S, Matsuoka Y, Papiol S, Begemann M, Ribbe K, doi:10.1038/emboj.2011.108 Ashton-Beaucage D, Therrien M, Friedrichs H, Radyushkin KA, Lemieux S, Perreault C, Roux PP, Mitochondria regulate autophagy Müller M, Benseler F, Riggert J, Kitano H. Falkai P, Bickeböller H, Nave KA, by conserved signalling pathways Mol Syst Biol. 6:453 Graef M and Nunnari J Brose N, Stühmer W, Ehrenreich H. doi:10.1038/emboj.2011.104 doi: 10.1002/emmm.201100135 IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease. Koltsida O, Hausding M, Stavropoulos Next issue Editor Yvonne Kaul A, Koch S, Tzelepis G, Ubel C, Kotenko Contributing editor Suzanne Beveridge SV, Sideras P, The next EMBOencounters issue – Autumn 2011 – will be Proofreading Meryl Schneider Lehr HA, Tepe M, Klucher KM, dispatched in October 2011. Please send your suggestions, Print layout Uta Mackensen Doyle SE, Neurath MF, Finotto S, contributions and news to: [email protected] Web version Sabine Rehberger-Schneider Andreakos E. by 16 September 2011. E-newsletter Sandra Krahl, Katja Linssen doi: 10.1002/emmm.201100142 7

Schönbrunn Palace: a former imperial 1400-room Rococo summer residence in Vienna © Schloß Schönbrunn Kultur- und Betriebsges.m.b.H. © Schloß Schönbrunn Kultur-

Giulio Superti-Furga, EMBO Member, the canal. The restaurant Motto am Fluss with Director of the Center for Molecular its impressive building overlooking the canal Things to do Medicine of the Austrian Academy of offers excellent food. Sciences: What every visitor to Vienna should not The Museumsquartier, a buzzing 60,000 miss, is a visit to one of the Heurigen, typi- in Vienna square metre cultural area that has been ex- cal Austrian wine taverns that serve only tensively renovated in the last decade, is their own wine. The most famous include To help The EMBO Meeting home to many museums, art galleries but also Sirbu and the traditional 10er Marie dating participants fi ll their free time bars in a stimulating setting. from 1740 and situated in the old city district in Vienna, we polled the local The Naschmarkt is the most popular market Alt-Ottakring. in Vienna with 1.5 kilometres of stands and For people interested in dancing, EMBO community and put shops selling products from all over the world. Volksgarten offers a relaxed atmosphere with together a list of their favourite To experience the summer feeling of a nice garden for refreshments. For a more spots for dining, shopping Vienna, go for dinner or drinks along the up-market option go to Passage, a futuris- Donaukanal – part of the Danube river that tic nightclub located in an old underground & culture. crosses the city. Have a cocktail at the famous passage. Tel Aviv, a sandy beach for chilling out along Nina Corsini, EMBO Fellow, postdoc at the Institute of Molecular Biotechnology: The Museum of Natural History in Vienna has an amazing collection of minerals, butterfl ies, stuffed animals, sea creatures, gem stones and corals, some of which were brought back to Vienna by adventurers almost 250 years ago. You can spend a whole rainy Sunday there exploring the exhibit and feeling like an adventurer yourself. My favourite piece is a hideous monster fi sh that, as it turns out, never existed, but was actually created ➞ ➞

Viennese by New hotspot for locals and guests: choice: the upscale restaurant Motto am Fluss offers Giulio © Marianne Greber chic interiors and excellent food Superti-Furga

➞ ➞ from several types of fi sh skin. Once you get tired from all the buzz, don’t forget to have a Wiener mélange at the beautiful café on the top fl oor – before you come back on Monday evening for The EMBO Meeting conference party. If there is a bit of sun in Vienna, you’ll be able to catch it in the outdoor part of the Palmenhaus Café, located in a former green- house at the Burggarten. Grab a coffee or a light meal (they offer very nice grilled fi sh), enjoy the beautiful view of the Burggarten or just touch up your sun tan.

Javier Martinez, EMBO Young Investigator, group leader at the Institute of Molecular Biotechnology: Vienna has some fabulous museums. Prob- ably the most famous is Albertina, situated

© Marianne Greber right in front of the Vienna Opera. The Upper The Danube canal runs through the heart of Vienna Belvedere hosts the world’s largest collection of Gustav Klimt and some of Egon Schiele’s Summer in the city most famous paintings. The gardens around Schönbrunn Palace are very nice to walk around and the Zoo in Vienna has a great new house for orangutans. Restaurant Seidl in Ungargasse 63 is excellent for Viennese cuisine. It offers the best schnitzel in town for reasonable prices and has a great wine list. For those who prefer a more exotic menu, I recommend maki sushi at Kiang, Sechskrügelgasse 2. © Marianne Greber

Javier Martinez (right) with his daughter Julia in Nina Cortesi relaxing in his favourite place for the the Palmenhaus Café original Viennese schnitzel 9

Ice and anther The winners of The EMBO Journal Cover Contest 2011 are Heiti Paves for the best scientifi c cover image and Dieter Lampl in the category best non-scientifi c cover image. A confocal image of an Arabidopsis thaliana anther fi lled with pollen grains received the highest scores from the jury in the scientifi c section and was showcased on the front cover of The EMBO Journal issue 30/09. The impressive Blue Ice of the glacier Perito Moreno in Patagonia, which headed the non-scientifi c list, decorated the front cover of issue 30/08.

This year, more than 3,000 images were submitted to this annual amateur contest. A gallery of the winning and the shortlisted pictures can be found at:

EMBO Scientiﬁ c Publications | Poster Prize competition Congratulations to the following winners of competitions held at recent meetings:

Luca Mazzarella Inês Pimenta de Castro Mattia Quattrocelli Anchal Chandra European Institute of Oncology, MRC-Toxicology Unit, Leicester, UK Interdepartmental Stem Cell Institute, Max Planck Institute for Molecular Milan, Italy Genetic analysis of mitochondrial Leuven, Belgium Physiology, Dortmund, Germany Stimulation of the insulin/IGF1 protein misfolding in Drosophila Myogenic-biased commitment in The GDI-like solubilizing factor pathway inhibits induction of melanogaster pericyte-derived iPSCs PDEdelta sustains the spatial Foxp3+ Tregs Presented at the EMBO Molecular Presented at the EMBO Conference organization and signaling of Presented at the EMBO Workshop, Medicine Workshop 2011, Series, Advances in Stem Cell Research RAS-family proteins Immunology and Metabolism Cell Death & Disease Paris, France Presented at the EMBO Conference Marseille, France Obergurgl, Austria 6 – 8 April, 2011 Series, SPATIAL 2011 – Systems 13 – 15 January, 2011 10 – 14 March, 2011 Dynamics of Intracellular Communication Leila Rieder Engelberg, Switzerland Martin Lehmann Hironobu Fujiwara Brown University, Providence, 15 – 19 May, 2011 University of Geneva, Switzerland Epithelial Cell Biology Laboratory, Rhode Island, USA Quantitative multicolour super- Cancer Research UK, Cambridge, UK A tale of two (or three or four) resolution microscopy reveals tether Role of basement membrane structures: in vivo demonstration of in HIV-1 interaction heterogeneity in establishing unique long-range secondary and tertiary Presented at the EMBO | EMBL microenvironmental niches in skin RNA structures directing editing Symposium, Seeing is Believing – Presented at the EMBO Conference Presented at the EMBO Workshop, Imaging the Processes of Life Series, Advances in Stem Cell Research Chromatin Structure, Organization and Heidelberg, Germany Paris, France Dynamics 17 – 20 March, 2011 6 – 8 April, 2011 Prague, Czech Republic 9 – 13 April, 2011

EVENTS FROM THE EMBO COMMUNITY

EMBO Member Gustav Ammerer and From 9 –16 September 2011, Biocenter The Champalimaud Neuroscience EMBO Fellow Isabel Varela-Nieto is EMBO/HHMI scientist Lumir Krejcˇí are of the University of Basel will celebrate Symposium to be held from co-organizing a series of Science for organizers of the Mendel Lectures – its 40th anniversary with a series of 18 – 21 September 2011 will bring Society events under the umbrella of a series of lectures held in the Mendel events for politicians, scientists and the together researchers from around the the Spanish Society for Biochemistry Museum in Brno, Czech Republic. general public. The events include a world who are interested in solving the and Molecular Biology (SEBBM) – one two-day scientifi c symposium organized puzzle of the brain. The symposium will of the largest scientifi c associations in The list of all talks planned for 2011 by EMBO Member Erich Nigg, Director take place at the Champalimaud Centre the country. The Magic of Proteins will and 2012 is available at of the Biocenter, and his team. for the Unknown in central Lisbon, be held on 23 September during the http://mlectures.ic.cz Portugal. It is co-organized by EMBO Researchers’ Night in Madrid. Further More information at Member Zachary F. Mainen. activities include participation in www.biozentrum.unibas.ch/40/ Madrid’s Science Fair with a meeting 40jahre40years.html More at on Artifi cial intelligence: science fi ction http://symposium.neuro. or truth? fchampalimaud.org/ More at www.sebbm.es

Royal opening for new plant laboratory £82 million facility headed by EMBO Member Elliot Meyerowitz ▼ Royal presence at the launch of a new research facility is a rare honour that was granted to Cambridge University in April this year, when Queen Elisabeth II came to the opening of The Sainsbury Laboratory. Her Majesty was received by EMBO Member Elliot Meyerowitz (pictured left), the inaugural director of this state-of-the-art plant sciences lab.

The facility was made possible by the £ 82 million grant from the Gatsby Charitable Foundation. It will focus on addressing some of the major environmental problems, such as the increasing strain on the world’s food supplies. The building will also be home to the University Herbarium – a unique collection of over one million pressed and dried plant specimens from all over © Nigel Luckhurst the world, including those collected by Charles Darwin on the Beagle voyage.

Late abstracts close 27 July 3rd Online registration closes 21 August Speakers include David Anderson Richard Axel Cori Bargmann advancing the life sciences Conference Bonnie Bassler Jeffrey Bennetzen chairs Evan Eichler Pascale Cossart Florian Engert Barry Dickson Brett Finlay 2011 Jane Langdale Susan Lindquist Edvard Moser VIENNA Special lectures Paul Rainey Mark Pagel Giacomo Rizzolatti 10 – 13 September Giacomo Rizzolatti Paul Schulze-Lefert see website Lucy Shapiro Keynote lectures Michael Stratton 21 concurrent Richard Axel Eric Wieschaus sessions covering Susan Lindquist Louis-Jeantet Prize the entire range for Medicine winners www.the-embo-meeting.org of the molecular [email protected] life sciences

© 2011 EMBO | Poster by S. Krahl © 2011 EMBO | Poster The EMBO Meeting is administered by the Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH – VAT Reg. No.: DE264471047 11 Better together Biocenter Finland – developing cost-efﬁ cient technology services at the national level

◗ At fi rst glance, Finland does not appear so welcoming to foreign scientists. “We are a restrictive country,” says Eero Vuorio, Finn- ish delegate to the EMBC, the intergovern- mental funding body of EMBO. “The average temperature is below that of a refrigerator; the language is not easy.” Still, the Nordic republic recruits skilled life scientists from all over the world to its universities. Most of them head for Finland’s capital city, Helsinki. Attracting students and researchers from abroad to peripheral cities is also one of the © Ari Aalto goals of Biocenter Finland (www.biocenter.fi ) – a new umbrella organization of six institutes more than generous investment in the middle Biocenter Finland director Eero Vuorio (left) and based at various Finnish universities. of the global fi nancial slump. “We learned one of its founders, Mart Saarma The idea is as simple as it is ambitious: the lesson during the severe crisis in the each of the six biocenters provides technology early nineties,” explains Eero, who heads the services for the benefi t of the entire commu- Biocenter Finland. This time, despite nation- nity – in its own area of specialization. The wide budget cuts, the government keeps up aim is to avoid unnecessary overlaps and its support for basic research. Finland spends invest in the newest technologies and equip- close to four per cent of its GDP on Research services. The acquired state-of-the-art instrument. While the transgenic mouse network & Development – a high share similar only to ments also help to increase the standard of is coordinated by the biocenter in Oulu, the countries like Sweden and Israel. It pays off. services at a national level. Another advan- Turku biocenter excels in services related to The life sciences sector in Finland is doing tage of coordinating all investments by one proteomics, and Helsinki is the fi rst address well and, internationally, Finnish researchers umbrella organization instead of six separate for all interested in next-generation sequenc- score highly in clinical research, with respect institutes is the easy reporting to the minis- ing technology. Other fi elds across the biocen- to the number of publications and the number try. “For the fi rst time, I can give the ministry ters include viral gene transfer, cell therapy of citations.” a comprehensive overview of our activities and bioinformatics. “Users shouldn’t pay Of the total of 45 million euros, 45 per cent on just one page,” says Eero. It doesn’t take more for our services even if they are based was invested into technological equipment, more than 45 minutes to draft a report on 500 kilometres away from Helsinki,” says 40 per cent went into hiring staff and the rest how funding has been used and how much EMBO Member Mart Saarma, one of the proj- of 15 per cent into machine maintenance and the universities subsidised it. So both Eero ect initiators. Geographical balance is key in subsidies. The networks on genome-wide and Mart are convinced that this very young this large, but extremely sparsely populated methods and proteomics received the biggest project is already a success. The online feed- country. share, fi ve million euros each. back forms that are submitted by users tell the This division of tasks was a prerequisite to By strengthening the existing and support- same story. “The Finns are very direct,” says receive public funding. Last year, the Finnish ing the emerging technologies, the new Eero. “If the users weren’t happy with what government transferred 45 million euros to virtual institute manages to avoid bottlenecks we offered them, they would have shared the network for the years 2011 to 2013 – a and prevent long online queues for certain their displeasure with us immediately.”

New Royal Society Fellows New Members and Foreign Associates of the National EMBO Members and Foreign Members: Academy of Sciences: who joined the ranks ❚ Robin Campbell Allshire ❚ Michael E. Goldberg ❚ Louise N. Johnson Foreign Associate of the Royal Society ❚ Doreen Cantrell ❚ Ira S. Mellman ❚ in the UK and ❚ ❚ Stephen O’Rahilly Alun Millward Davies Margaret Buckingham Foreign Associate Foreign Associate the US National ❚ Steven J. Gamblin ❚ ❚ Shinya Yamanaka Academy of Sciences ❚ Franz-Ulrich Hartl Foreign Associate Joanne Chory Foreign Associate this year: Foreign Member ❚ Phillip Allen Sharp Foreign Member

Opportunities for medical research in Brisbane, Australia Frank Gannon on his ﬁ rst impressions at a new job in the southern hemisphere. ©2011 Tony Phillips for Queensland Institute of Medical Research ©2011 Tony

◗ After my time in EMBO and in Ireland, I heavily in the required infrastructure. QIMR genetics, biology, population health, compu- moved to the Queensland Institute of Medical is the largest medical research institute in tational biology, molecular and cell biology. Research (QIMR) in Brisbane as its director Australia and is currently undergoing a We are looking for excellent researchers in the fi rst week in January this year. Bris- revitalisation. This is triggered in part by an for the current phase of expansion and invite bane was in the news at that time because of expansion that provides a new building and people at any career stage to apply – including its severe weather, but now it has returned to will allow the institute to grow from 600 to those who are well established researchers normal blue skies, mid 20°C and all the buzz over 1,000 researchers. looking for a fresh adventure. Please contact of a booming city. In addition to the usual research infra- me at [email protected] and learn I had some knowledge of Australia and structure, we also have specialist containment more about the benefi ts of working at QIMR of Brisbane from previous visits, but living rooms for insects, GMP level cellular therapy in Brisbane at www.qimr.edu.au. here allows a better appreciation. Brisbane is production, expanding imaging facilities and beautifully located on the banks of a river. It a linkage with a clinical trial unit. We cooper- BY FRANK GANNON is compact and well serviced with the usual ate with the local universities and are located Director, Queensland Institute of transport systems, enriched by a frequent next door to the largest teaching hospital in Medical Research river-based boat shuttle service. It is, for Brisbane. Translation to the clinic, under- Frank Gannon is a former Executive Director a northern European, like living in a holi- pinned by excellent fundamental research, is of EMBO from 1994 – 2007. day mode; outdoor meals, excellent cafés, an important driver of our activities. active culture centres, diverse cultures, great QIMR focuses on three major research beaches close by and everywhere the innate themes: Cancer, Infectious Diseases and Australian friendliness and ease of contact. Mental Health/Complex Disorders. These end Brisbane is striving to be the leading points are supported by signifi cant skills and research city in Australia and is investing commitments in the areas of immunology,

ORGANIZED BY EMBO Molecular Medicine Molecular Stefanie Dimmeler CHIEF EDITOR Insights for Innovative

KEYNOTE LECTURES Therapies Philippe Sansonetti Edison Liu 1–3 December 2011 | EMBL Heidelberg | Germany

SPEAKERS Kari Alitalo Peter Carmeliet Matthias Hentze Manolis Pasparakis Stylianos Antonarakis Giulio Cossu Sakari Kauppinen Austin Smith Karen Avraham Bart de Strooper Anthony Monaco Giulio Superti-Furga Yann Barrandon Ivan Dikic Salvador Moncada Christof von Kalle Anne Brunet Peter Dirks Edward Morrisey Christian Weber

Additional speakers will be EARLY REGISTRATION ABSTRACT SUBMISSION DEADLINE CONTACT selected from abstracts. 15 July 2011 15 October 2011 [email protected]

Barcelona: hub of chromatin research The Catalan capital city is the ﬁ rst address for meetings on chromatin & epigenetics

◗ These days, Catalan institutes – and many support of the local government, this initiative international organizations, including EMBO might become reality as early as next year. – head for Barcelona to host their conferenc- Antoni Castellà, Secretary for Universities and es. In the fi eld of chromatin and epigenetics Research in the Catalan government, called it alone, four conferences have taken place in an “excellent idea”. the city of Gaudi during the fi rst half of 2011. by MARCUS BUSCHBECK and HARVEY EVANS One of them was the Signaling to Chromatin in Differentiation and Cancer, organized by the Institute of Predictive and Personalized Medicine of Cancer (IMPPC) and held in the medieval setting of the Catalan Academy of Science. Indeed, Barcelona has a long-standing 2009 history in chromatin research. In the early 80’s, investigators from Barcelona pioneered the chromatin fi eld by describing the struc- Nat Struct Mol Biol ture of the chromatin fi ber. After 20 rather , calm years, the renaissance of the fi eld as et al. epigenetics happened to coincide with the

Catalan government initiative to boost basic and Schwarts

science by creating independent research et al. centers of excellence. Many of these centers have strong programmes in chromatin and Luisa Lente’s design epigenetics. As a consequence, the annual showing a nucleosome meeting of the local chromatin club now in Miró style will be used counts on more than 30 participating research as logo of the future groups. Barcelona Chromatin

Conference series ©Illustration by Luisa Lente for Tilgner So it does not come as a surprise that the directors of the major biomedical insti- For more information on future & past conferences go to: tutes are now discussing the possibility of www.imppc.org/conference2011/ www.pebc.cat launching a jointly organized series of annual www.crg.es http://blocs.iec.cat/scb/category/ Barcelona Chromatin Conferences. With the www.irbbarcelona.org seccio/biologia-molecular/

A new Graduate School offering research- New programmes for based Ph.D. degree in biology has been launched at the Stowers Institute for young researchers Medical Research, Kansas City, US. “We plan to take exceptional students from around the world and train them in interdisciplinary The Centre for Integrative Genomics in Mitochondria and Cancer is the topic of science,” says EMBO Member Robb Krumlauf, Lausanne, headed by EMBO Member Nouria the residential summer school organized scientifi c director at Stowers. Hernandez, offers new training opportunities by EMBO Member Howy Jacobs and Laurie S. The programme focuses on practical train- for aspiring doctoral students. The Doctoral Kaguni from the University of Tampere. The ing in an environment built upon cutting- Program in Integrative Experimental school will be held at the Keurusselkä lake- edge investigation in many facets of modern & Computational Biology aims to train side spa hotel in a scenic region of central molecular biology. Successful candidates students in the conceptual, experimental Finland, from 3–10 September 2011. will receive in-depth training in the latest and computational approaches needed for Programme includes a lecture series by methodologies of modern molecular biol- data production and quantitative analysis. international research leaders, group-study ogy and learn how to create interdisciplin- Topics offered span the study of molecules, exercises by students and a mini-sympo- ary approaches to interesting biological cells, organisms and their environment, sium involving leading Nordic scientists. problems. The fi rst students will enter in behaviour and evolutionary biology. Application deadline is 15 July. September 2012. Additional information can be found at: More information at: More at: www.unil.ch/iecb www.uta.fi /ibt/fi nmit/ www.stowers.org/gradschool summerschool_2011.php

EMBO Members EMBO Young Investigators

Ernst Jung Prize InBev-Baillet Latour Health Prize 2011 Award for Basic/Translational 2011 EACR Cancer Researcher Award Ernst Jung Foundation for InBev-Baillet Latour Fund Research European Association for Cancer Science and Research Jean-Laurent Casanova was awarded European Society for Clinical Research (EACR) The 2011 Ernst Jung Medal for the international InBev-Baillet Latour Investigation (ESCI) EACR will present Jesus Gil from MRC Medicine in Gold was awarded to Health Prize for his pioneering work Caetano Reis e Sousa won the 2011 Clinical Sciences Centre London, UK, Michel Lazdunski for his research in the fi eld of “infectious diseases and ESCI Award for Basic/Translational with the 2011 Cancer Researcher in ion channels, which have led to immunology”. Casanova discovered that Research for his groundbreaking Award ‘Highly Commended’ during breakthroughs in the fi elds of physiology, life-threatening infections of childhood, contributions to the understanding the European Multidisciplinary Cancer pathology and pharmacology. such as tuberculosis, pneumococcal of innate immune mechanisms and Congress to be held in Stockholm, Hans C. Clevers has received the disease, herpes simplex encephalitis and dendritic cell biology, as well as for his Sweden, from 23–27 September 2011 2011 Ernst Jung Medical Award in chronic mucocutaneous candidiasis, may active leadership role in biomedical recognition of his research work in be caused by single-gene inborn errors research in Europe. This 10,000-euro- explaining the molecular causes of of immunity. This annual prize, worth award is given to biomedical EMBO Fellows colon cancer, which is expected to be of 250,000 euros, is the most important investigators below the age of 45 for Medal of Honor for Women in Science benefi t for the further development of science prize being awarded in Belgium. excellence in clinically oriented basic or L’Oreal innovative therapies. translational research. Hooke Medal Joana Marques was recently awarded G.H.A. Clowes Memorial Award British Society of Cell Biology (BSCB) Jeang Retrovirology Prize one of the L’Oréal Medals of Honor for American Association for Cancer Alex P. Gould received the 2011 Hooke Ming K. Jeang Foundation Women in Science, worth 20,000 euros. Research (AACR) Medal of the British Society of Cell Michael H. Malim is the recipient of the This award aims to improve the position Yosef Shiloh received the 51st Biology. The prize is awarded annually to 2010 M Jeang Retrovirology Prize. The of women in science by recognising Annual AACR Clowes Memorial an emerging leader in cell biology who prize, which is awarded annually, and is outstanding female researchers who Award for his studies of the cellular has made an outstanding contribution partly sponsored by the Ming K. Jeang have contributed to scientifi c progress. DNA damage response and the rare to this fi eld within the fi rst ten years of Foundation, recognizes groundbreaking Sloan Research Fellowships genomic instability syndrome ataxia- establishing his or her own lab. Gould research from retrovirologists aged Alfred P. Sloan Foundation telangiectasia (A-T). The winner was was presented with the medal at the 45 – 60. According to the jury, “Professor Ertug˘rul M. Özbudak is one of the granted a 10,000-US dollar-honorarium BSCB annual meeting at the University Malim made key scientifi c contributions recipients of the 2011 Sloan Research and delivered a lecture at the AACR of Kent, UK, in April this year. to our understanding of HIV-1 Fellowships worth 50,000 US dollars. 102nd Annual Meeting in Orlando, US, in replication, which also illuminated new Awarded annually since 1955, the April this year. Canada Gairdner International Award fundamental biological processes”. The Gairdner Foundation fellowships are given to early-career AACR also recognized the work of Pier scientists and scholars in recognition Paolo Pandolfi , who received the Both Jules A. Hoffmann and Shizuo Akira receive this award worth of achievement and the potential to 2011 Pezcoller Foundation / AACR contribute substantially to their fi elds. International Award for Cancer 100,000 US dollars “for groundbreaking Upcoming deadlines Research for his outstanding work in discoveries and defi nition of the family the fi eld of cancer genetics and mouse of Toll-like receptors and the array models for cancer. This work has of microbial compounds that they recognize to provide innate resistance to contributed to new therapies for 15 August 15 October treating cancers. infection”. EMBO FEBS | EMBO Long-Term Fellowships Women in Science Award

A GOOD READ – PUBLICATIONS FROM THE EMBO COMMUNITY

Research articles

In vivo imaging of Tregs providing Evolution and metabolic signifi cance 5-hydroxymethylcytosine in the The Machado-Joseph disease immune privilege to the of the urea cycle in photosynthetic mammalian zygote is linked with deubiquitylase ATX-3 couples longevity hematopoietic stem cell niche diatoms epigenetic reprogramming and proteostasis Chris Bowler (EMBO Member) et al. Thorsten Hoppe Cristina Lo Celso (EMBO Fellow) et al. Joana Marques (EMBO Fellow) et al. Nature 473, 203–207 | 2 May 2011 Nature Communications 2, 241 (EMBO Young Investigator) et al. Nature | 9 June 2011 15 March 2011 Nature Cell Biology 13, 273–281 doi: 10.1038/nature10160 CPEB and two poly(A) polymerases 13 February 2011 control miR-122 stability and p53 Molecular basis of purine-rich RNA Latent TGF-β binding protein 3 mRNA translation recognition by the human SR-like pv The molecular basis of sex: identifi es a second heart fi eld in Stephanie Nottrott (EMBO Fellow) et al. Antoine Cléry (EMBO Fellow) et al. linking yeast to human zebrafi sh Nature 473, 105–108 | 10 April 2011 Nature Structural & Molecular Biology Luca Jovine Christian Mosimann (EMBO Fellow) et al. 18, (EMBO Young Investigator) et al. Functional specifi city of local synaptic 443-450 | 13 March 2011 Nature | 29 May 2011 Molecular Biology and Evolution connections in neocortical networks The structural basis of agonist- 31 January 2011 doi: 10.1038/nature10094 Sonja B. Hofer (EMBO Fellow) et al. induced activation in constitutively doi: 10.1093/molbev/msr026 Nature 473, 87–91 | 10 April 2011 Photosynthetic electron partitioning active rhodopsin between [FeFe]-hydrogenase and Auxin triggers a genetic switch Jörg Standfuss (EMBO Fellow) et al. Nature 471, 656–660 ferredoxin:NADP+-oxidoreductase Ive De Smet (EMBO Fellow) et al. Books 9 March 2011 (FNR) enzymes in vitro Nature Cell Biology 13, 611–615 10 April 2011 Bacterial Stress Responses Iftach Yacoby (EMBO Fellow) et al. The structural basis for MCM2–7 2nd edition Proceedings of the National Academy Dynamic regulation of helicase activation by GINS and Cdc45 Gisela Storz & Regine Hengge of Sciences | 23 May 2011 5-hydroxymethylcytosine in the mouse Alessandro Costa (EMBO Fellow) et al. (EMBO Member) (eds) doi: 10.1073/pnas.1103659108 genome during ES cell differentiation Nature Structural & Molecular Biology ASM Press, Washington DC Joana Marques (EMBO Fellow) et al. 18, 471–477 | 6 March 2011 ISBN-13: 978-155581-621-6 Acetylation-dependent regulation of Nature 473, 398–402 | 3 April 2011 November 2010 Oct4 kinetics predict cell lineage endothelial Notch signalling by the SHARPIN forms a linear ubiquitin patterning in the early mammalian Microbial Biochemistry SIRT1 deacetylase ligase complex regulating NF-κB embryo Georges N. Cohen (EMBO Member) Holger Gerhardt activity and apoptosis Nicolas Plachta (EMBO Fellow) et al. Springer Verlag (EMBO Young Investigator) et al. Sigrid S. Skanland (EMBO Fellow) et al. Nature Cell Biology 13, 337–337 ISBN 978-90-481-9436-0 Nature 473, 234–238 | 12 May 2011 Nature 471, 637–641 | 31 March 2011* 1 March 2011 2011