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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
Laureadas Com O Nobel Na Fisiologia Ou Medicina (1995-2015)
No trono da ciência II: laureadas com o Nobel na Fisiologia ou Medicina (1995-2015) On the Throne of Science II: Nobel Laureates in Physiology or Medicine (1995-2015) LUZINETE SIMÕES MINELLA Universidade Federal de Santa Catarina | UFSC RESUMO O artigo dá continuidade a uma pesquisa mais ampla sobre as trajetórias das doze cientistas que receberam o Nobel na Fisiologia ou Medicina entre 1947 e 2015. Na fase anterior foram analisadas as trajetó- rias das cinco pioneiras, laureadas entre 1947 e 1988 e nesta segunda etapa, são abordadas suas sucessoras, as sete premiadas entre 1995 e 2015. A análise das suas autobiografias, discursos e palestras disponíveis no site do prêmio, além de outras fontes, se fundamenta numa perspectiva balizada pela crítica feminista à ciência bem como pelos avanços dos estudos do campo de gênero e ciências e da história da ciência. O artigo tenta identificar semelhanças e diferenças entre as pioneiras e as sucessoras na tentativa de contribuir para o debate sobre as especificidades da feminização das carreiras científicas. 85 Palavras-chave Gênero e Ciências – Nobel – Fisiologia ou Medicina. ABSTRACT The article gives continuity to a broader research on the trajectories of the twelve scientists who received the Nobel Prize in Physiology or Medicine between 1947 and 2015. In the previous phase, the trajectories of the five pioneers awarded between 1947 and 1988 were analyzed, and, in this second phase, their successors, the seven awarded between 1995 and 2015, were approached. The analysis of their autobiographies, speeches and lectures available on the award site, in addition to other sources, is based on a feminist critique of science as well as advances of the studies in the field of gender and science and the history of science. -
Research Counts, Not the Journal Miguel Abambres, Tiago Ribeiro, Ana Sousa, Eva Lantsoght
Research Counts, Not the Journal Miguel Abambres, Tiago Ribeiro, Ana Sousa, Eva Lantsoght To cite this version: Miguel Abambres, Tiago Ribeiro, Ana Sousa, Eva Lantsoght. Research Counts, Not the Journal. 2018. hal-02074859v3 HAL Id: hal-02074859 https://hal.archives-ouvertes.fr/hal-02074859v3 Preprint submitted on 15 Nov 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License Abambres M, et al. (2018). Research Counts, Not the Journal, hal-02074859 © 2018 by Abambres et al. (CC BY 4.0) Research Counts, Not the Journal Miguel Abambres 1, Tiago Ribeiro 2, Ana Sousa 2 and Eva Lantsoght 3, 4 1 R&D, Abambres’ Lab, 1600-275 Lisbon, Portugal; [email protected] 2 Independent Researcher, Lisbon, Portugal 3 Researcher, Department of Engineering Structures, Delft University of Technology, The Netherlands; [email protected] 4 Professor, Politécnico, Universidad San Francsico de Quito, Quito, Ecuador Abstract: ‘If there is one thing every bibliometrician agrees, is that you should never use the journal impact factor (JIF) to evaluate research performance for an article or an individual – that is a mortal sin’. -
Die Woche Spezial
In cooperation with DIE WOCHE SPEZIAL >> Autographs>vs.>#NobelSelfie Special >> Big>Data>–>not>a>big>deal,> Edition just>another>tool >> Why>Don’t>Grasshoppers> Catch>Colds? SCIENCE SUMMIT The>64th>Lindau>Nobel>Laureate>Meeting> devoted>to>Physiology>and>Medicine More than 600 young scientists came to Lindau to meet 37 Nobel laureates CAREER WONGSANIT > Women>to>Women: SUPHAKIT > / > Science>and>Family FOTOLIA INFLAMMATION The>Stress>of>Ageing > FLASHPICS > / > MEETINGS > FOTOLIA LAUREATE > CANCER RESEARCH NOBEL > LINDAU > / > J.>Michael>Bishop>and GÄRTNER > FLEMMING > JUAN > / the>Discovery>of>the>first> > CHRISTIAN FOTOLIA Human>Oncogene EDITORIAL IMPRESSUM Chefredakteur: Prof. Dr. Carsten Könneker (v.i.S.d.P.) Dear readers, Redaktionsleiter: Dr. Daniel Lingenhöhl Redaktion: Antje Findeklee, Jan Dönges, Dr. Jan Osterkamp where>else>can>aspiring>young>scientists> Ständige Mitarbeiter: Lars Fischer Art Director Digital: Marc Grove meet>the>best>researchers>of>the>world> Layout: Oliver Gabriel Schlussredaktion: Christina Meyberg (Ltg.), casually,>and>discuss>their>research,>or>their> Sigrid Spies, Katharina Werle Bildredaktion: Alice Krüßmann (Ltg.), Anke Lingg, Gabriela Rabe work>–>or>pressing>global>problems?>Or> Verlag: Spektrum der Wissenschaft Verlagsgesellschaft mbH, Slevogtstraße 3–5, 69126 Heidelberg, Tel. 06221 9126-600, simply>discuss>soccer?>Probably>the>best> Fax 06221 9126-751; Amtsgericht Mannheim, HRB 338114, UStd-Id-Nr. DE147514638 occasion>is>the>annual>Lindau>Nobel>Laure- Geschäftsleitung: Markus Bossle, Thomas Bleck Marketing und Vertrieb: Annette Baumbusch (Ltg.) Leser- und Bestellservice: Helga Emmerich, Sabine Häusser, ate>Meeting>in>the>lovely>Bavarian>town>of> Ute Park, Tel. 06221 9126-743, E-Mail: [email protected] Lindau>on>Lake>Constance. Die Spektrum der Wissenschaft Verlagsgesellschaft mbH ist Kooperati- onspartner des Nationalen Instituts für Wissenschaftskommunikation Daniel>Lingenhöhl> GmbH (NaWik). -
Nobel Week Stockholm 2018 – Detailed Information for the Media
Nobel Week Stockholm • 2018 Detailed information for the media December 5, 2018 Content The 2018 Nobel Laureates 3 The 2018 Nobel Week 6 Press Conferences 6 Nobel Lectures 8 Nobel Prize Concert 9 Nobel Day at the Nobel Museum 9 Nobel Week Dialogue – Water Matters 10 The Nobel Prize Award Ceremony in Stockholm 12 Presentation Speeches 12 Musical Interludes 13 This Year’s Floral Decorations, Concert Hall 13 The Nobel Banquet in Stockholm 14 Divertissement 16 This Year’s Floral Decorations, City Hall 20 Speeches of Thanks 20 End of the Evening 20 Nobel Diplomas and Medals 21 Previous Nobel Laureates 21 The Nobel Week Concludes 22 Follow the Nobel Prize 24 The Nobel Prize Digital Channels 24 Nobelprize org 24 Broadcasts on SVT 25 International Distribution of the Programmes 25 The Nobel Museum and the Nobel Center 25 Historical Background 27 Preliminary Timetable for the 2018 Nobel Prize Award Ceremony 30 Seating Plan on the Stage, 2018 Nobel Prize Award Ceremony 32 Preliminary Time Schedule for the 2018 Nobel Banquet 34 Seating Plan for the 2018 Nobel Banquet, City Hall 35 Contact Details 36 the nobel prize 2 press MeMo 2018 The 2018 Nobel Laureates The 2018 Laureates are 12 in number, including Denis Mukwege and Nadia Murad, who have been awarded the Nobel Peace Prize Since 1901, the Nobel Prize has been awarded 590 times to 935 Laureates Because some have been awarded the prize twice, a total of 904 individuals and 24 organisations have received a Nobel Prize or the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel -
Randy W. Schekman, Phd
Randy W. Schekman, PhD Current Position Professor of molecular and cell biology at the University of California, Berkeley Investigator at the Howard Hughes Medical Institute Editor-in-Chief, eLIFE Journal Education BA, molecular biology, University of California, Los Angeles PhD, biochemistry, Stanford University Awards Nobel Prize in Physiology or Medicine 2013 (shared with James E. Rothman and Thomas C. Südhof ) Albert Lasker Award for Basic Medical Research Eli Lilly Research Award in Microbiology and Immunology Lewis S. Rosenstiel Award in Basic Biomedical Science, Brandeis University Gairdner Foundation International Award Louisa Gross Horwitz Prize, Columbia University 2008 Dickson Prize in Medicine, University of Pittsburgh E.B. Wilson Medal, American Society for Cell Biology Memberships US National Academy of Sciences American Academy of Arts and Sciences American Society of Cell Biology American Association for the Advancement of Science American Philosophical Society Biography Traffic inside a cell is as complicated as rush hour near any metropolitan area. But drivers know how to follow the signs and roadways to reach their destinations. How do different cellular proteins "read" molecular signposts to find their way inside or outside of a cell? For the past three decades, Randy Schekman has been characterizing the traffic drivers that shuttle cellular proteins as they move in membrane-bound sacs, or vesicles, within a cell. His detailed elucidation of cellular travel patterns has provided fundamental knowledge about cells and has enhanced understanding of diseases that arise when bottlenecks impede some of the protein flow. His work earned him one of the most prestigious prizes in science, the 2002 Albert Lasker Award for Basic Medical Research, which he shared with James Rothman. -
OF the UNIVERSITY of CALIFORNIA Editorial Board
OF THE UNIVERSITY OF CALIFORNIA Editorial Board Rex W Adams Carroll Brentano Ray Cohig Steven Finacom J.R.K. Kantor Germaine LaBerge Ann Lage Kaarin Michaelsen Roberta J. Park William Roberts Janet Ruyle Volume 1 • Number 2 • Fall 1998 ^hfuj: The Chronicle of the University of California is published semiannually with the goal of present ing work on the history of the University to a scholarly and interested public. While the Chronicle welcomes unsolicited submissions, their acceptance is at the discretion of the editorial board. For further information or a copy of the Chronicle’s style sheet, please address: Chronicle c/o Carroll Brentano Center for Studies in Higher Education University of California, Berkeley, CA 94720-4650 E-mail [email protected] Subscriptions to the Chronicle are twenty-seven dollars per year for two issues. Single copies and back issues are fifteen dollars apiece (plus California state sales tax). Payment should be by check made to “UC Regents” and sent to the address above. The Chronicle of the University of California is published with the generous support of the Doreen B. Townsend Center for the Humanities, the Center for Studies in Higher Education, the Gradu ate Assembly, and The Bancroft Library, University of California, Berkeley, California. Copyright Chronicle of the University of California. ISSN 1097-6604 Graphic Design by Catherine Dinnean. Original cover design by Maria Wolf. Senior Women’s Pilgrimage on Campus, May 1925. University Archives. CHRONICLE OF THE UNIVERSITY OF CALIFORNIA cHn ^ iL Fall 1998 LADIES BLUE AND GOLD Edited by Janet Ruyle CORA, JANE, & PHOEBE: FIN-DE-SIECLE PHILANTHROPY 1 J.R.K. -
January 24, 2020 President Donald J. Trump the White House
January 24, 2020 President Donald J. Trump The White House 1600 Pennsylvania Ave NW Washington, DC 20500 Dear President Trump: As 21 Nobel Prize award-winning scientists and scholars we are writing to express our strong support for immediate open access to the results of research funded with U.S. taxpayer dollars. We understand there is an Executive Order under consideration by your Administration that would remove the 12-month embargo currently in place for access to published, taxpayer-funded research and strongly urge you to sign this order. Immediate online access to the bounty of research funded and published with U.S. support is fundamental to realising the full potential of our nation’s $65b investment in science. We must ensure that human and machine readers alike have open access to the reports, data, and code stemming from our work in order that it may be built upon swiftly, efficiently, and be translated effectively into benefits for society. Such barriers must be removed. The work of our nation’s seven million scientists 1 is inhibited so long as there are delays before we are able to read the latest work in our fields. Improving public health through the investigation of new treatments and potential cures for disease is delayed. Growing the U.S. economy through the translation of research into new services, tools and businesses is delayed. Progress across all of our fields is delayed by the embargo on access. Immediate, open online access to U.S. research will create valuable visibility. We publish our findings so that they may be read and built upon. -
Is Neuroscience a Bigger Threat Than Artifical Intelligence
Is Neuroscience a Bigger Threat than Artificial Intelligence? IBM’s Jeopardy winning computer Watson is a serious threat, not just to the livelihood of medical diagnosticians, but to other professionals who may find themselves going the way of welders. Besides its economic threat, the advance of AI seems to pose a cultural threat: if physical systems can do what we do without thought to give meaning to their achievements, the conscious human mind will be displaced from its unique role in the universe as a creative, responsible, rational agent. But this worry has a more powerful basis in the Nobel Prize winning discoveries of a quartet of neuroscientists—Eric Kandel, John O’Keefe, Edvard, and May-Britt Moser. For between them they have shown that the human brain doesn’t work the way conscious experience suggests at all. Instead it operates to deliver human achievements in the way IBM’s Watson does. Thoughts with meaning have no more role in the human brain than in artificial intelligence. Consciousness tells us that we employ a theory of mind, both to decide on our own actions and to predict and explain the behavior of others. According to this theory there have to be particular belief/desire pairings somewhere in our brains working together to bring about movements of the body, including speech and writing. Which beliefs and desires in particular? Roughly speaking it’s the contents of beliefs and desires—what they are about—that pair them up to drive our actions. The desires represent the ends, the beliefs record the available means to attain them. -
The 2014 Nobel Prize in Physiology Or Medicine John O´Keefe May-Britt
PRESS RELEASE 2014‐10‐06 The Nobel Assembly at Karolinska Institutet has today decided to award The 2014 Nobel Prize in Physiology or Medicine with one half to John O´Keefe and the other half jointly to May‐Britt Moser and Edvard I. Moser for their discoveries of cells that constitute a positioning system in the brain ____________________________________________________________________________________________________ How do we know where we are? How can we find the way from one place to another? And how can we store this information in such a way that we can immediately find the way the next time we trace the same path? This year´s Nobel Laureates have discovered a positioning system, an “inner GPS” in the brain that makes it possible to orient ourselves in space, demonstrating a cellular basis for higher cognitive function. In 1971, John O´Keefe discovered the first component of this positioning system. He found that a type of nerve cell in an area of the brain called the hippocampus that was always activated when a rat was at a certain place in a room. Other nerve cells were activated when the rat was at other places. O´Keefe concluded that these “place cells” formed a map of the room. More than three decades later, in 2005, May‐Britt and Edvard Moser discovered another key component of the brain’s positioning system. They identified another type of nerve cell, which they called “grid cells”, that generate a coordinate system and allow for precise positioning and pathfinding. Their subsequent research showed how place and grid cells make it possible to determine position and to navigate. -
ERC Press Release O in 2012, Prof
Press release 6 October 2014 Nobel Prize in Physiology/Medicine to two European Research Council grantees It was announced today by the Nobel Assembly at Karolinska Institutet, Stockholm, that the 2014 Nobel Prize in Physiology/Medicine has been awarded to Professor Edvard I. Moser and Professor May-Britt Moser, both ERC Advanced Grant holders, together with Professor John O´Keefe, "for their discoveries of cells that constitute a positioning system in the brain". On this occasion, European Commission President José Manuel Barroso said: "I warmly congratulate John O´Keefe, May-Britt Moser and Edvard Moser on their achievement. I am particularly proud that both May-Britt and Edvard Moser are holders of European Research Council Advanced Grants. The ERC supports the very best pioneering researchers across Europe, and has made a real impact since its launch in 2007. This is why we decided on a significant boost for the ERC budget in our new research and innovation programme, Horizon 2020." The President of the European Research Council (ERC), Prof. Jean-Pierre-Bourguignon, commented: "On behalf of the ERC, I would like to extend warm congratulations to this year’s three Nobel laureates in Physiology or Medicine. We are very proud that the European Research Council has funded two of the winners - Professors Edvard I. Moser and May-Britt Moser. Their ERC Advanced Grants contributed in a significant way to their ground-breaking research on the navigation system of the brain. Today's news confirms that the ERC invests in the best minds – whether young or senior - to support their most innovative ideas at the cutting edge." This is the third time that a Nobel Prize goes to top researchers funded by the ERC since its launch. -
May-Britt Moser Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Grid Cells, Place Cells and Memory Nobel Lecture, 7 December 2014 by May-Britt Moser Norwegian University of Science and Technology (NTNU), Trondheim, Norway. n 7 December 2014 I gave the most prestigious lecture I have given in O my life—the Nobel Prize Lecture in Medicine or Physiology. Afer lectures by my former mentor John O’Keefe and my close colleague of more than 30 years, Edvard Moser, the audience was still completely engaged, wonderful and responsive. I was so excited to walk out on the stage, and proud to present new and exciting data from our lab. Te title of my talk was: “Grid cells, place cells and memory.” Te long-term vision of my lab is to understand how higher cognitive func- tions are generated by neural activity. At frst glance, this seems like an over- ambitious goal. President Barack Obama expressed our current lack of knowl- edge about the workings of the brain when he announced the Brain Initiative last year. He said: “As humans, we can identify galaxies light years away; we can study particles smaller than an atom. But we still haven’t unlocked the mystery of the three pounds of matter that sits between our ears.” Will these mysteries remain secrets forever, or can we unlock them? What did Obama say when he was elected President? “Yes, we can!” To illustrate that the impossible is possible, I started my lecture by showing a movie with a cute mouse that struggled to bring a biscuit over an edge and home to its nest. Te biscuit was almost bigger than the mouse itself.