FY2006 Society for Neuroscience Annual Report
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Laureadas Com O Nobel Na Fisiologia Ou Medicina (1995-2015)
No trono da ciência II: laureadas com o Nobel na Fisiologia ou Medicina (1995-2015) On the Throne of Science II: Nobel Laureates in Physiology or Medicine (1995-2015) LUZINETE SIMÕES MINELLA Universidade Federal de Santa Catarina | UFSC RESUMO O artigo dá continuidade a uma pesquisa mais ampla sobre as trajetórias das doze cientistas que receberam o Nobel na Fisiologia ou Medicina entre 1947 e 2015. Na fase anterior foram analisadas as trajetó- rias das cinco pioneiras, laureadas entre 1947 e 1988 e nesta segunda etapa, são abordadas suas sucessoras, as sete premiadas entre 1995 e 2015. A análise das suas autobiografias, discursos e palestras disponíveis no site do prêmio, além de outras fontes, se fundamenta numa perspectiva balizada pela crítica feminista à ciência bem como pelos avanços dos estudos do campo de gênero e ciências e da história da ciência. O artigo tenta identificar semelhanças e diferenças entre as pioneiras e as sucessoras na tentativa de contribuir para o debate sobre as especificidades da feminização das carreiras científicas. 85 Palavras-chave Gênero e Ciências – Nobel – Fisiologia ou Medicina. ABSTRACT The article gives continuity to a broader research on the trajectories of the twelve scientists who received the Nobel Prize in Physiology or Medicine between 1947 and 2015. In the previous phase, the trajectories of the five pioneers awarded between 1947 and 1988 were analyzed, and, in this second phase, their successors, the seven awarded between 1995 and 2015, were approached. The analysis of their autobiographies, speeches and lectures available on the award site, in addition to other sources, is based on a feminist critique of science as well as advances of the studies in the field of gender and science and the history of science. -
The Creation of Neuroscience
The Creation of Neuroscience The Society for Neuroscience and the Quest for Disciplinary Unity 1969-1995 Introduction rom the molecular biology of a single neuron to the breathtakingly complex circuitry of the entire human nervous system, our understanding of the brain and how it works has undergone radical F changes over the past century. These advances have brought us tantalizingly closer to genu- inely mechanistic and scientifically rigorous explanations of how the brain’s roughly 100 billion neurons, interacting through trillions of synaptic connections, function both as single units and as larger ensem- bles. The professional field of neuroscience, in keeping pace with these important scientific develop- ments, has dramatically reshaped the organization of biological sciences across the globe over the last 50 years. Much like physics during its dominant era in the 1950s and 1960s, neuroscience has become the leading scientific discipline with regard to funding, numbers of scientists, and numbers of trainees. Furthermore, neuroscience as fact, explanation, and myth has just as dramatically redrawn our cultural landscape and redefined how Western popular culture understands who we are as individuals. In the 1950s, especially in the United States, Freud and his successors stood at the center of all cultural expla- nations for psychological suffering. In the new millennium, we perceive such suffering as erupting no longer from a repressed unconscious but, instead, from a pathophysiology rooted in and caused by brain abnormalities and dysfunctions. Indeed, the normal as well as the pathological have become thoroughly neurobiological in the last several decades. In the process, entirely new vistas have opened up in fields ranging from neuroeconomics and neurophilosophy to consumer products, as exemplified by an entire line of soft drinks advertised as offering “neuro” benefits. -
Socity the Physiologicalsociety Newsletter
p rVI i~ ne Pal Newsette Socity The PhysiologicalSociety Newsletter Contents 1 Physiological Sciences at Oxford - Clive Ellory 2 Neuroscience Research at Monash University - Uwe Proske 4 Committee News 4 Grants for IUPS Congress, Glasgow, 1993 4 COPUS - Committee on the Public Understanding of Science 4 Nominations for election to Membership 5 Computers in Teaching Initiative 5 Membership Subscriptions for 1993 5 Benevolent Fund 6 Wellcome Prize Lecturer 6 Retiring Committee Members 8 Letters & Reports 8 Society's Meetings 9 Animal Research - Speaking in Schools 9 Colin Blakemore - FRS 9 Happy 80th Birthday 10 Talking Point in the Biological Sciences - Simon Brophy,RDS 11 Chance & Design 11 Views 11 Muscular Dystrophy Group - SarahYates 14 The Multiple Sclerosis Society - John Walford 14 British Diabetic Association - Moira Murphy 15 Biomedical Research in the SERC - Alan Thomas 16 Cancer Research Campaign - TA Hince 18 The Wellcome Trust - JulianJack 22 Articles 22 Immunosuppression in Multiple Sclerosis - A N Davison 23 Hypoxia - a regulator of uterine contractions in labour? - Susan Wray 25 Pregnancy and the vascular endothelium - Lucilla Poston 28 Society Sponsored Events 28 IUPS Congress 93, list of themes 32 Notices 35 Tear-Out Forms 35 Affiliates 37 Grey Book Updates Administrations & Publications Office, P 0 Box 506, Oxford, OXI 3XE Tel: (0865) 798498 Fax: (0865) 798092 Produced by Kwabena Appenteng, Heather Dalitz and Clare Haigh The PhysiofogicafSociety 9ewsfetter Physiological Sciences at Oxford The two year interval since the last meeting of the Society in Lecturer in the department for some time, has been appointed to Oxford corresponds with the time I have been standing in for a university lectureship, in association with Balliol College. -
Network AW 2004.Qxd 10/11/2004 13:40 Page 1
Network AW 2004.qxd 10/11/2004 13:40 Page 1 network Autumn/Winter 2004 News, views and information from the Medical Research Council In this issue... MRC integral to UK clinical Funding update research drive News of competition for MRC funding in Speaking at the Academy of Medical Sciences (AMS) in 2004/05 and the application June, Lord Warner of Brockley announced the formation review process of the UK Clinical Research Collaboration (UKCRC) – a page 2 multi-partner initiative launched to give a major boost to clinical research in the UK.The Government has also set up a new MRC/Health Departments (HDs) Joint Health Francis Crick Delivery Group to increase the strategic coordination of 1916-2004 publicly funded medical research and support the UKCRC. A colleague pays tribute to one of the founding fathers UKCRC of molecular biology The UKCRC was a key recommendation of the Research page 4 for Patient Benefit Working Party set up in response to "We welcome Chancellor Gordon Brown's budget influential reports in Autumn 2003 by the AMS and the announcement of a cash injection for medical research Government's Bioscience Innovation and Growth Team. over the next four years, and will be working even more Basic Technology With a mission to coordinate and transform clinical closely with the Government and the Health Departments November showcase for research in the UK, the partnership will involve the MRC, to address national health priorities in the years ahead." progress by MRC scientists Government, the NHS, academia, medical charities, Colin Blakemore, MRC Chief Executive in the Research Councils UK industry and the public. -
The Use of Non-Human Primates in Research in Primates Non-Human of Use The
The use of non-human primates in research The use of non-human primates in research A working group report chaired by Sir David Weatherall FRS FMedSci Report sponsored by: Academy of Medical Sciences Medical Research Council The Royal Society Wellcome Trust 10 Carlton House Terrace 20 Park Crescent 6-9 Carlton House Terrace 215 Euston Road London, SW1Y 5AH London, W1B 1AL London, SW1Y 5AG London, NW1 2BE December 2006 December Tel: +44(0)20 7969 5288 Tel: +44(0)20 7636 5422 Tel: +44(0)20 7451 2590 Tel: +44(0)20 7611 8888 Fax: +44(0)20 7969 5298 Fax: +44(0)20 7436 6179 Fax: +44(0)20 7451 2692 Fax: +44(0)20 7611 8545 Email: E-mail: E-mail: E-mail: [email protected] [email protected] [email protected] [email protected] Web: www.acmedsci.ac.uk Web: www.mrc.ac.uk Web: www.royalsoc.ac.uk Web: www.wellcome.ac.uk December 2006 The use of non-human primates in research A working group report chaired by Sir David Weatheall FRS FMedSci December 2006 Sponsors’ statement The use of non-human primates continues to be one the most contentious areas of biological and medical research. The publication of this independent report into the scientific basis for the past, current and future role of non-human primates in research is both a necessary and timely contribution to the debate. We emphasise that members of the working group have worked independently of the four sponsoring organisations. Our organisations did not provide input into the report’s content, conclusions or recommendations. -
BY COLIN BLAKEMORE and RICHARD C. VAN SLUYTERS* from the Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG (Received 20 August 1973)
J. Physiol. (1974), 237, pp. 195-216 195 With 8 text-figures Printed in Great Britain REVERSAL OF THE PHYSIOLOGICAL EFFECTS OF MONOCULAR DEPRIVATION IN KITTENS: FURTHER EVIDENCE FOR A SENSITIVE PERIOD BY COLIN BLAKEMORE AND RICHARD C. VAN SLUYTERS* From the Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG (Received 20 August 1973) SUMMARY 1. It was confirmed that suturing the lids of one eye (monocular deprivation), until only 5 weeks of age, leaves virtually every neurone in the kitten's visual cortex entirely dominated by the other eye. On the other hand, deprivation of both eyes causes no change in the normal ocular dominance of cortical neurones, most cells being clearly binocularly driven. 2. Kittens were monocularly deprived until various ages, from 5 to 14 weeks, at which time reverse suturing was performed: the initially deprived right eye was opened and the left eye closed for a further 9 weeks before recording from the visual cortex. 3. Reverse suturing at 5 weeks caused a complete switch in ocular dominance: every cell was dominated by the initially deprived right eye. Reverse suturing at 14 weeks, however, had almost no further effect on ocular dominance: most cells were still driven solely by the left eye. Animals reverse sutured at intermediate ages had cortical neurones strongly dominated by one eye or the other, and they were organized into clear columnar groups according to ocular dominance. 4. Thus, between 5 weeks and 4 months of age, there is a period of declining sensitivity to both the effects of an initial period of monocular deprivation and the reversal of those effects by reverse suturing. -
MRC Annual Review 2004/05 1 the MRC Works Across All Medical Research Introduction Disciplines and with a Wide Range of Stakeholders to Improve Human Health
Working together to improve human health 2004/05 Annual Review The Medical Research Council (MRC) is the UK’s leading publicly funded biomedical research organisation. Our mission is to: ● Encourage and support high-quality research with the aim of improving human health. ● Produce skilled researchers, and to advance and disseminate knowledge and technology to improve the quality of life and economic competitiveness in the UK. ● Promote dialogue with the public about medical research. Welcome 1 Introduction 2 Working in partnership 4 Accelerating research 8 A sense of achievement 12 14 Cancer 16 Cardiovascular disease and stroke 18 Respiratory disease 20 Infectious disease 22 Neurosciences and mental health 24 The ageing population 26 Obesity, diet and diabetes 28 Health inequalities 30 Clinical investigation and trials 32 From discovery to treatments Welcome From Professor Colin Blakemore MRC Chief Executive In this Annual Review you will read about some of the many achievements of MRC-funded scientists in 2004/05 and the partnerships that have made much of this vital work possible. The research that we fund is aimed at tackling major challenges to human health. These range from potentially devastating infections such as AIDS and avian flu to the gradual increase in ageing-related diseases resulting from longer life expectancy. But it is not enough for us simply to support and carry out the highest-quality biomedical science. We must relate what we are doing in the laboratory to clinical research involving patients and the work of the NHS. By focussing on medical research ‘in the round’, as a continuum involving interaction and two-way feedback between a variety of disciplines, we can ensure that our scientists’ discoveries are translated into health benefits for people as soon as possible. -
Is Neuroscience a Bigger Threat Than Artifical Intelligence
Is Neuroscience a Bigger Threat than Artificial Intelligence? IBM’s Jeopardy winning computer Watson is a serious threat, not just to the livelihood of medical diagnosticians, but to other professionals who may find themselves going the way of welders. Besides its economic threat, the advance of AI seems to pose a cultural threat: if physical systems can do what we do without thought to give meaning to their achievements, the conscious human mind will be displaced from its unique role in the universe as a creative, responsible, rational agent. But this worry has a more powerful basis in the Nobel Prize winning discoveries of a quartet of neuroscientists—Eric Kandel, John O’Keefe, Edvard, and May-Britt Moser. For between them they have shown that the human brain doesn’t work the way conscious experience suggests at all. Instead it operates to deliver human achievements in the way IBM’s Watson does. Thoughts with meaning have no more role in the human brain than in artificial intelligence. Consciousness tells us that we employ a theory of mind, both to decide on our own actions and to predict and explain the behavior of others. According to this theory there have to be particular belief/desire pairings somewhere in our brains working together to bring about movements of the body, including speech and writing. Which beliefs and desires in particular? Roughly speaking it’s the contents of beliefs and desires—what they are about—that pair them up to drive our actions. The desires represent the ends, the beliefs record the available means to attain them. -
The 2014 Nobel Prize in Physiology Or Medicine John O´Keefe May-Britt
PRESS RELEASE 2014‐10‐06 The Nobel Assembly at Karolinska Institutet has today decided to award The 2014 Nobel Prize in Physiology or Medicine with one half to John O´Keefe and the other half jointly to May‐Britt Moser and Edvard I. Moser for their discoveries of cells that constitute a positioning system in the brain ____________________________________________________________________________________________________ How do we know where we are? How can we find the way from one place to another? And how can we store this information in such a way that we can immediately find the way the next time we trace the same path? This year´s Nobel Laureates have discovered a positioning system, an “inner GPS” in the brain that makes it possible to orient ourselves in space, demonstrating a cellular basis for higher cognitive function. In 1971, John O´Keefe discovered the first component of this positioning system. He found that a type of nerve cell in an area of the brain called the hippocampus that was always activated when a rat was at a certain place in a room. Other nerve cells were activated when the rat was at other places. O´Keefe concluded that these “place cells” formed a map of the room. More than three decades later, in 2005, May‐Britt and Edvard Moser discovered another key component of the brain’s positioning system. They identified another type of nerve cell, which they called “grid cells”, that generate a coordinate system and allow for precise positioning and pathfinding. Their subsequent research showed how place and grid cells make it possible to determine position and to navigate. -
ERC Press Release O in 2012, Prof
Press release 6 October 2014 Nobel Prize in Physiology/Medicine to two European Research Council grantees It was announced today by the Nobel Assembly at Karolinska Institutet, Stockholm, that the 2014 Nobel Prize in Physiology/Medicine has been awarded to Professor Edvard I. Moser and Professor May-Britt Moser, both ERC Advanced Grant holders, together with Professor John O´Keefe, "for their discoveries of cells that constitute a positioning system in the brain". On this occasion, European Commission President José Manuel Barroso said: "I warmly congratulate John O´Keefe, May-Britt Moser and Edvard Moser on their achievement. I am particularly proud that both May-Britt and Edvard Moser are holders of European Research Council Advanced Grants. The ERC supports the very best pioneering researchers across Europe, and has made a real impact since its launch in 2007. This is why we decided on a significant boost for the ERC budget in our new research and innovation programme, Horizon 2020." The President of the European Research Council (ERC), Prof. Jean-Pierre-Bourguignon, commented: "On behalf of the ERC, I would like to extend warm congratulations to this year’s three Nobel laureates in Physiology or Medicine. We are very proud that the European Research Council has funded two of the winners - Professors Edvard I. Moser and May-Britt Moser. Their ERC Advanced Grants contributed in a significant way to their ground-breaking research on the navigation system of the brain. Today's news confirms that the ERC invests in the best minds – whether young or senior - to support their most innovative ideas at the cutting edge." This is the third time that a Nobel Prize goes to top researchers funded by the ERC since its launch. -
Peder Sather Center for Advanced Study
Peder Sather Center for Advanced Study A Research and Educational Collaboration between Norway and the University of California, Berkeley sathercenter.berkeley.edu Peder Sather Center for Advanced Study Background and Purpose The primary mission of the Peder Sather Center for Advanced Study is to strengthen ongoing research collaborations and foster the develop- ment of new collaborations between the University of California, Berkeley and the consortium of nine participating Norwegian academic institutions. The Peder Sather Center for Advanced Study’s funding enables UC Berkeley faculty to conduct exploratory and cutting edge research in tandem with leading researchers from the following nine Norwegian higher education institutions and the Research Council of Norway: Peder Sather (1810-1886) Peder Sather, a farmer’s son from Norway, BI Norwegian Business School (BI) emigrated to New York City in 1832. Norwegian School of Economics (NHH) There he started up as a servant and lottery ticket seller before opening an exchange Norwegian University of Science and Technology (NTNU) brokerage, later to become a full-fledged University of Agder (UiA) banking house. When gold was discovered in California, banker Francis Drexel University of Bergen (UiB) offered Peder Sather and his companion, Edward Church, a large loan to establish a Norwegian University of Life Sciences (NMBU) bank in San Francisco. From 1863 Peder University of Oslo (UiO) Sather went on as the sole owner of the bank and in the late 1860’s he had become University of Stavanger (UiS) one of California’s richest men. UiT The Arctic University of Norway Peder Sather was a public-spirited man, a philanthropist and an eager supporter of The Peder Sather Center selects projects for support and serves as the public education on all levels and for both sexes. -
List of Entries
List of Entries Essays are shown in bold A Afferent Fibers (Neurons) Acid-Sensing Ion Channels AFibers(A-Fibers) NICOLAS VOILLEY,MICHEL LAZDUNSKI A Beta(β) Afferent Fibers Acinar Cell Injury A Delta(δ) Afferent Fibers (Axons) Acrylamide A Delta(δ)-Mechanoheat Receptor Acting-Out A Delta(δ)-Mechanoreceptor Action AAV Action Potential Abacterial Meningitis Action Potential Conduction of C-Fibres Abdominal Skin Reflex Action Potential in Different Nociceptor Populations Abduction Actiq® Aberrant Drug-Related Behaviors ® Ablation Activa Abnormal Illness Affirming States Activation Threshold Abnormal Illness Behavior Activation/Reassurance GEOFFREY HARDING Abnormal Illness Behaviour of the Unconsciously Motivated, Somatically Focussed Type Active Abnormal Temporal Summation Active Inhibition Abnormal Ureteric Peristalsis in Stone Rats Active Locus Abscess Active Myofascial Trigger Point Absolute Detection Threshold Activities of Daily Living Absorption Activity ACC Activity Limitations Accelerated Recovery Programs Activity Measurement Acceleration-Deceleration Injury Activity Mobilization Accelerometer Activity-Dependent Plasticity Accommodation (of a Nerve Fiber) Acupuncture Acculturation Acupuncture Efficacy EDZARD ERNST Accuracy and Reliability of Memory Acupuncture Mechanisms β ACE-Inhibitors, Beta( )-Blockers CHRISTER P.O. C ARLSSON Acetaminophen Acupuncture-Like TENS Acetylation Acute Backache Acetylcholine Acute Experimental Monoarthritis Acetylcholine Receptors Acute Experimental