SIMB MolecularPioneering NewsResearch CEO News magazine of the Society for Industrial BiochemistMicrobiologyUniversity and Biotechnology DNAv n October/November/DecemberPolymerase 2019 .69 .4 • www.simbhq.orgBusinessScientific Entrepreneurial Industry Corporation FounderCommercializing Interferon Constellation Genethe New Biology: ApplicationChairman A Tribute to Patent Pharmaceutical PCR Recombinant BreakthroughDiagnostic Cloning RonaldVenture E. Cape Leadership Cetus Biotechnology2020 Election PresidentInterleukinfor Board of DirectorsBusinessman Call for

SIMB Award

4 . .69 2019 October/November/December n

v Nominations Journal of Industrial Microbiology & Biotechnology Impact Factor 2.993

The Journal of Industrial Microbiology and Biotechnology is an international journal which publishes papers in all areas of applied microbiology, e.g., biotechnology, fermentation and cell culture, biocatalysis, environmental microbiology, natural products discovery and biosynthesis, metabolic engineering, genomics, bioinformatics, food microbiology.

Editor-in-Chief • Ramon Gonzalez, Rice University, Houston, TX, USA Special Issue Natural Product Discovery and Editors Development in the Genomic Era; Mar. 2019 • S. Bagley, Michigan Tech, Houghton, MI, USA • R. H. Baltz, CognoGen Biotech. Consult., Sarasota, FL, USA • T. W. Jeffries, University of Wisconsin, Madison, WI, USA • T. D. Leathers, USDA ARS, Peoria, IL, USA • M. J. López López, University of Almeria, Almeria, Spain • C. D. Maranas, Pennsylvania State Univ., Univ. Park, PA, USA • S. Park, UNIST, Ulsan, Korea • J. L. Revuelta, University of Salamanca, Salamanca, Spain • B. Shen, Scripps Research Institute, Jupiter, FL, USA • D. K. Solaiman, USDA ARS, Wyndmoor, PA, USA • Y. Tang, University of California, Los Angeles, CA, USA • E. J. Vandamme, Ghent University, Ghent, Belgium • J. Yang, Amgen Inc., Oak Park, CA, USA • H. Zhao, University of Illinois, Urbana, IL, USA 5 Most Cited Articles of JIMB in 2018: Authors Title Year Cites Katz, Leonard; Baltz, Richard H. Natural product discovery: past, present, and future 2016 63 Multiplex gene editing of the Yarrowia lipolytica genome using the CRISPR-Cas9 Gao, Shuliang, et al. 2016 26 system Genetic manipulation of secondary metabolite biosynthesis for improved Baltz, Richard H. 2016 23 production in Streptomyces and other actinomycetes Baltz, Richard H. Gifted microbes for genome mining and natural product discovery 2017 20 Katz, Micah; Hover, Bradley Culture-independent discovery of natural products from soil metagenomes 2017 15 M.; Brady, Sean F. Submission information Electronic access ▶ ww.springer.com/10295 ▶ link.springer.com/journal/10295 contents news 114 NEWSWORTHY SIMB News Melanie Mormile | Editor-in-Chief 116 IN MEMORIAM: JEAN BRENCHLEY Elisabeth Elder | Associate Editor Stephanie Gleason | Associate Editor feature Kristien Mortelmans | Associate Editor COMMERCIALIZING THE NEW BIOLOGY: Vanessa Nepomuceno | Associate Editor 118 A TRIBUTE TO RONALD E. CAPE DESIGN & PRODUCTION Katherine Devins | Production Manager meetings 125 NATURAL PRODUCTS 2020 BOARD OF DIRECTORS 127 SBFC 2020 President Jan Westpheling 128 SIMB ANNUAL MEETING 2020 President-Elect Steve Decker 129 INDUSTRIAL MICROBIOLOGY MEETS MICROBIOME (IMMM) 2020 Past President Steve Van Dien Secretary Elisabeth Elder members Treasurer Laura Jarboe 134 LETTER FROM THE SIMB PRESIDENT Directors Katy Kao SOCIETY RESOLUTIONS Priti Pharyka 135 Tiffany Rau 138 CALL FOR AWARD NOMINATIONS Michael Resch 139 NEW BOARD OF DIRECTORS HEADQUARTERS STAFF 140 SIMB ELECTION 2020 Christine Lowe | Executive Director Jennifer Johnson | Director of Member Services book review Tina Hockaday | Meeting Coordinator Suzannah Citrenbaum | Web Manager 132 THE POISON SQUAD Esperanza Montesa | Accountant in every issue EDITORIAL CORRESPONDENCE CORPORATE MEMBERS Melanie R. Mormile 110 Email: [email protected] 111 LETTER FROM THE EDITOR-IN-CHIEF 133 SIMB STRATEGIC PLAN ADVERTISING For information regarding rates, contact 147 CALENDAR OF EVENTS SIMB News 150 SIMB CORPORATE MEMBERSHIP APPLICATION 3929 Old Lee Highway, Suite 92A Fairfax, VA 22030-2421 P: 703-691-3357 ext 30 F:703-691-7991 Email: [email protected] www.simbhq.org SIMB News (ISSN 1043-4976), is published On the cover quarterly, one volume per year, by the Word map Society for Industrial Microbiology and Biotechnology and is provided to all SIMB MolecularPioneering members. Research CEO POSTMASTER: Send address changes to CONTACT SIMB DNABiochemistUniversity (703) 691-3357 SIMB News, 3929 Old Lee Highway, Suite 92A, Polymerase BusinessScientific Entrepreneurial Fairfax, VA 22030-2421 Industry Corporation Executive Director Founder Christine Lowe, Ext. 26 Copyright © 2019, Society for Industrial Interferon Constellation Microbiology and Biotechnology. Director of Member Services Gene Jennifer Johnson, Ext. 23 All rights reserved. ApplicationChairman Patent Meeting Coordinator Pharmaceutical PCR Recombinant Tina Hockaday, Ext. 24 BreakthroughDiagnostic Cloning Venture Web Manager Leadership Cetus Suzannah Citrenbaum, Ext. 27 Biotechnology Accountant PresidentInterleukin Businessman Esperanza Montesa, Ext. 22

October • November • December 2019 SIMB NEWS 109 corporate members

Diamond Members Silver Members ICM, Inc. Applikon Biotechnology, Inc. Kuhner Shaker, Inc. Corteva Agriscience Novozymes, Inc. Envera, LLC Sartorius Stedium Biotech Eppendorf Gold Members Gardner Industries, Inc. Global Bioingredients, Inc. DCI-Biolafitte KATZEN International, Inc. Flownamics Lallemand, Inc. Genesis Biosciences, Inc. Moubio, LLC Hamilton Company Mycosynthetix, Inc. INFORS USA Panlabs Biologics, Inc. m2P Labs, Inc. Tatua USA Ltd. Marcor, an Azelis company Traders Protein Procelys Xylome Sensient Global Bionutrients Bronze Members BioIntelligence Technologies Pneumatic Scale Angelus Institutional Members ERWAT Golden Leaf Biomanufacturing Training and Education Center - North Carolina State University

110 SIMB NEWS www.simbhq.org editor's corner Letter from the Editor-in-Chief

The end of the calendar year always brings one to reflect on what has occurred in the past and an anticipation for what will come in the new year. The current issue of SIMB News certainly suits this condition. In remembrance, the feature article provides an overview of the great impact that Ronald E. Cape had on the development of the field of biotechnology and industrial microbiology. Jean E. Brenchley is also remembered for her contributions to the field of biotechnology and her impact at Pennsylvania State University. Resolutions marking the achievements of the Society for Industrial Microbiology and Biotechnology over the past year are also provided. With an eye towards the future, the Society’s Strategic Plan is included in this issue. For the Society to fulfill its Plan, the participation of the Society’s membership is required. One critical way that all members can be active participants in the Society is to vote in the upcoming election for President, Treasurer, and Board of Directors. Be sure to carefully read the biographies of all the candidates, make your decisions for each position, and vote! In addition to voting, there are conferences being held throughout 2020 that will appeal to all members. Be sure to attend at least one conference and participate as fully as you are able. In closing, I hope that 2020 will be a successful and enjoyable year for you! Sincerely, Melanie R. Mormile

Editor-in-Chief, SIMB News [email protected]

October • November • December 2019 SIMB NEWS 111 SAVE THE DATE Industrial Microbiology Meets Microbiome (IMMM) 2020 San Diego, CA November 8–10, 2020 www.simbhq.org/immm TIME TO RENEW! Individual and corporate membership renewals for 2020 are due! Visit www.simbhq.org to renew today. news Newsworthy

Organizations Urge Federal Agencies to Balance Security Considerations with Impacts on Scientific Collaborations

In a September 4, 2019 letter, sixty science, engineering, and international education organizations, have urged the heads of the White House Office of Science and Technology Policy (OSTP), the National Science Foundation (NSF), the National Institutes of Health (NIH), the Department of Energy (DOE), and the Department of Defense (DOD) to consider a wide range of stakeholder perspectives as the agencies work together to address issues of foreign influence on U.S. research.

The letter reads, “While we must be vigilant to safeguard research, we must also ensure that the U.S. remains a desirable and welcoming destination for researchers from around the world. Finding the appropriate balance between our nation’s security and an open, collaborative scientific environment requires focus and due diligence.”

The agencies have been tasked with working together through the new National Science and Technology Council (NSTC) Joint Committee on Research Environments to develop policies and procedures that address issues related to the participation of international researchers in the U.S. scientific enterprise. The letter warns about a rising concern among U.S. and international scientists that “new policies and procedures under consideration to minimize security risks will have the unintended effect of harming the scientific enterprise.”

114 SIMB NEWS www.simbhq.org news Newsworthy

NSB Calls for Growing the Skilled Technical Workforce

The National Science Board (NSB) — the governing body for the National Science Foundation (NSF) — has released a new report titled, “The Skilled Technical Workforce: Crafting America’s Science and Engineering Enterprise.” The report highlights contributions of the skilled technical workforce (STW) and calls for action to grow this segment of the U.S. science and engineering (S&E) workforce.

The NSB report (https://www.nsf.gov/nsb/publications/2019/nsb201923.pdf?ct=t(AIBS_PPR_September16_2019) draws attention to the workforce of 17 million people who use S&E skills in their job but do not have a bachelor’s degree. “These individuals bring critical thinking, design, digital, math, and coding skills to work as auto mechanics, health care technicians, electricians, welders, computer systems analysts and administrators, and operators of ‘smart’ infrastructure,” reads the report. “They also contribute to the nation’s S&E enterprise, accounting for more than 50 percent of all workers in many of America’s advanced industries.”

“K-12 schools, 2-year colleges, 4-year colleges and universities, and other education and workforce development programs are all integral, synergistic parts of a whole that we need to foster a STEM-capable workforce,” said NSB Chair Diane Souvaine at a report rollout on Capitol Hill.

The report offers four recommendations for policymakers and S&E leaders: “Change the Message,” which involves countering negative perceptions and raising awareness of skilled technical workforce jobs; “Focus on the Data,” which involves collecting and sharing data on the education, skills, and workforce characteristics of the STW; “Leverage Federal Investments,” which involves leveraging the federal programs and investments that support STW-related programs; and “Build Partnerships,” which involves education institutions, industry, and government working as partners to grow the STEM-capable U.S. workforce.

The report was prepared by NSB’s Task Force on the Skilled Technical Workforce. NSB held five listening sessions around the country to gather feedback from over 200 individuals from 65 locations, including faculty and students at community colleges and technical schools, regional and local industry leaders, and local policymakers. According to Victor McCrary, who chairs the task force, the STW has been long underappreciated, but it “has and will continue to be essential to America’s economic prosperity, our scientific and technological competitiveness, and our national security.” He indicated that according to some projections, “by 2022, we will need 3.4 million more skilled technical workers in this country.”

October • November • December 2019 SIMB NEWS 115 news In Memoriam: Jean Brenchley

Many in the membership of SIMB will recall that Jean E. Brenchley was an active member of the Society until 2006. We are saddened to report that Jean passed away on Tuesday, July 9, 2019.

Jean received her B.S. in biology from Mansfield University, Mansfield, PA, in 1965, after which she obtained a M.S. in marine microbiology from the University of California, San Diego, in 1967, followed by her Ph.D. in microbiology from the University of California, Davis, in 1970. She held a 1-year post-doctoral appointment in the Biology Department of the Massachusetts Institute of Technology, Cambridge, MA, and then joined the faculty of the Microbiology Department at Pennsylvania State University (Penn State), University Park in 1971 as Assistant Professor and subsequently was promoted to Associate Professor. In 1977, Jean continued her teaching and research activity at the Biological Sciences Department of Purdue University, West Lafayette, IN, being promoted to Professor of Biology in 1979. From 1981 to 1984, she was Research Director for Microbial Biochemistry at Genex Corporation, Gaithersburg, MD, before moving back to Penn State in 1984 as Head of the Department of Microbiology and Cell Biology and also as founding Director of the Penn State Biotechnology Institute which she established at the request of Penn State’s President Bryce Jordan. Through extensive public appearances, she raised millions of dollars for the institute and oversaw its design, construction and outfitting. She established a fermentation pilot plant and directed the start of short courses and workshops in which modern scale-up procedures were acquired by scientists from across the United States as well as from foreign countries. Upon concluding administrative duties in 1990, she returned to research and teaching as Professor of Microbiology and Biotechnology until her retirement with emeritus status from Penn State in 2011.

Jean always focused on microorganisms - their biochemical, genetic, and environmental properties. Her research revealed many interesting features of these smallest living organisms. Initially much of her academic attention was devoted to the genetics and metabolism of amino acids in species of Salmonella but when she returned to research in 1990, her interests successfully broadened to cover biotechnological applications of psychrophilic (cold-loving) microbes. Her interest in novel psychrophiles and their cold-active enzymes meshed well with biotechnological and commercial applications being developed for these microorganisms and further expanded into the exploration of microbial diversity in cold environments like Greenland glacier ice samples and ice cores extracted from Antarctic regions. These later studies involved collaboration with Penn State geoscientists to recover microbes from 120,000 year-old glacial ice core samples. When coupled with their growth characteristics and metagenomic analyses, the results usually led to the discovery of new microorganisms, including several novel ultramicrobacterial species, all of which continue to amaze researchers with their survival properties over millennia as well as their evolutionary adaptation to cold functionality. To assist with these studies, she trained numerous post-doctoral and graduate students who subsequently established their own careers as industrial, governmental and academic scientists. All credit her encouragement and leadership qualities as important attributes of the training they received under her direction.

Among her many honors and awards received, she received the Waksman Award for Outstanding Contributions in Microbiology from the Theobald Smith Society (1985), the Alice Evans Award from the American Society for Microbiology (1996) for her longstanding commitment to the professional development of women in

116 SIMB NEWS www.simbhq.org news

microbiology, and a Research Career Development Award from NIH (1976-1981). She was elected President of the American Society for Microbiology (1986) and accepted as a Fellow of the American Academy of Microbiology (1987). She later was named a Fellow of the American Association for the Advancement of Science (1994) and a Fellow of the Society for Industrial Microbiology (1998).

Material taken from Dr. Jean Brenchley’ obituary: https://kochfuneralhome.com/tribute/details/1926/Jean- Brenchley/obituary.html#tribute-start

October • November • December 2019 SIMB NEWS 117 feature

Commercializing the New Biology: A Tribute to Ronald E. Cape

Joan W. Bennett and Ellen Daniell

118 SIMB NEWS www.simbhq.org feature

INTRODUCTION

Ronald E. Cape, a biochemist and businessman who helped shape modern biotechnology, died on

January 2, 2015. He was 81. Ron was best known as one of the co- founders of Cetus Corporation.

Throughout his long professional life, Ron was a champion of biotechnology. For many years, he was an active member of the Ron Cape, Bob Schwartz and Jennie Hunter-Cevera at the 1986 SIM Annual Meeting in San Francisco, California Society for Industrial Microbiology, regularly attending the annual meetings, and tirelessly promoting biotechnology. Nowadays, it is commonplace knowledge that money can be made by exploiting breakthroughs in molecular biology. However, during the late 1960s and early 1970s, Ron was one of the few visionaries who realized that the transformative powers of the new molecular biology could be harnessed to make new - and profitable - commercial products. This insight was years before the first paper on gene cloning, before it was possible to sequence DNA, and decades before advances in computation power, next generation sequencing, the internet and other technical commonalities of the 21st century. Ron helped pioneer the integration of breakthrough discoveries in our ability to manipulate DNA with a traditional businessman’s focus on the bottom line.

October • November • December 2019 SIMB NEWS 119 feature

and several Nobel Prizes had been awarded for these and other breakthroughs. Soon to come were gene cloning and monoclonal antibodies. Because of his knowledge of biochemistry and business, Ron was well equipped to join with several other future-thinking men to found Cetus Scientific Laboratories (later Cetus Corporation) in 1971. The other founders were Moshe Alafi, a venture capitalist; Peter. J. Farley, who had both a medical degree and an MBA; Donald Glaser, the 1960 Nobel laureate in physics for his development of the bubble chamber; and Calvin Ward, a bench scientist. The basic idea was for Cetus to do for-profit biological research. Ron was fond of telling potential investors that Cetus would “find answers to questions that are not yet known.” In the early days, Ron served as president, chairman, and Chief Executive Officer (CEO) while Glaser served as Chairman of the Board of Scientific Advisors. After internal struggles over future directions and leadership roles, Alafi and Ward sold their stock in 1977. Alafi went on to become a seed investor in several other successful biotechnology companies including Biogen, Amgen, Ron Cape at SIM Annual Meeting – Baltimore, 1987 and Applied Biosystems. Ward went on to become a patent lawyer and has published an on-line, highly readable account of the early Ron was born on October 11, 1932 in Montreal, Canada where his days of Cetus (Ward, 2015). In 1978, Farley became president and Ron father ran a cosmetics company and owned six drugstores. Growing continued as chairman and CEO. Farley left Cetus in 1983 to form his up, there was a family expectation that eventually Ron would take own company, leaving Ron as the only one of the original founders to over his father’s business. After high school, he entered Princeton guide the company during the following transformative years. University where he majored in chemistry, was president of Court Club, and was coxswain of the 150-lb crew team. He graduated from Ron was proud of the fact that he named the company. He said that Princeton in 1953, summa cum laude and first in his class. Ron then he had conceived the name “Cetus” for the fledgling company by moved to Harvard University where he received an MBA in 1955, again selecting it from a star map of the night sky. In Greek mythology, graduating with high academic honors. Following expectations, he Cetus is the sea monster that eats Andromeda. Apparently, the returned to Montreal, worked in the family business, married, bought a founders had considered Andromeda as a possible name based on house, and fathered two daughters. Then, wanting “something more,” the 1969 bestselling thriller novel The Andromeda Strain. Ron knew he returned to graduate school and earned a PhD in biochemistry that the astronomical constellations Andromeda and Cetus were from McGill University in 1967. Upon receipt of a postdoctoral found near to one another and selected Cetus for its proximity. (Note: fellowship at the University of California at Berkeley, he moved with another version of the naming story is told by Calvin Ward who had his family to the San Francisco Bay Area. When the fellowship ended been attacked by a large ‘sea creature’ while diving. This shark attack in 1970, Ron found himself facing a return to Montreal and the family became “a whale of a tale”. According to this version, on hearing the business. Because he and his family had fallen in love with California, story, Ron had pointed out that the whale constellation was called Ron was determined to figure out a way to make a living in or near Cetus (Vettel 2006; Ward 2015). San Francisco. Whatever the lore about the naming of Cetus, it was an auspicious THE FOUNDING OF CETUS CORPORATION time to found a company based on the promise of the “new biology.” Within a few years recombinant DNA research - a process developed The 1970s were an exciting time for molecular biology. The structure at universities in the Bay Area - revolutionized biology. Co-founder of DNA had been elucidated, the genetic code had been cracked, Don Glaser had observed that microbiologists performed many

120 SIMB NEWS www.simbhq.org feature manual, time consuming, repetitive tasks in in order to grow and screen microbes. Glaser used his engineering talents to develop automated equipment for performing these tasks. In the early years, Cetus entered into several joint ventures doing contract research in traditional industrial microbiology using the automated equipment, partnering with Schering-Plough Corporation on antibiotics development and with National Distillers on industrial alcohol production.

During the early years, Ron put his managerial gifts to work ensuring that the people working for Cetus would have a great deal of freedom in figuring out ways exploit molecular biology in commercial arenas. He firmly believed that good scientists, if left alone without micromanagement, would produce extraordinary path-breaking research. As recombinant DNA technology emerged and gene cloning became a possibility, there was a conflict within the company about whether to stay with traditional industrial microbiology approaches, or whether to move into gene cloning. Ron, with his Vivian Moses and Ron Cape at SIM Annual Meeting in instinct for important scientific frontiers, felt strongly that the future Chicago, Illinois success of Cetus was with “the cloners” and he was instrumental in Ron stepped aside, chaired annual meetings of the Board, but mostly hiring David Gelfand in 1976 to start a recombinant DNA division at immersed himself in biotechnology-promoting activities outside of the company. the company, while ceding most of the authority in Cetus to Fildes.

THE GLORY DAYS OF CETUS CORPORATION During the early 1980s, Cetus was perhaps the largest company doing research on the application of recombinant DNA to pharmaceutical In 1981, Cetus made a large initial public offering (IPO). Cetus shares and other applications. For several years, with interest rates high, were offered at $23.00 each and as Ron later bragged, “Wall Street money raised during the IPO served as a kind of endowment. The swallowed the whole thing.” The company raised $108 million, which company worked simultaneously to produce several potential at the time was the most money ever raised in an IPO, surpassing anticancer and antivirus drugs including the tumor necrosis factor, a record set the previous year by Apple Computer, which had colony stimulating factor-1, interleukin-2 (IL-2), beta interferon, raised $101.2 million (Lueck, 1981). With the influx of funds, Cetus and two immunotoxins. The Cetus portfolio also included some expanded rapidly, hired dozens of new employees, and embarked diagnostic tests. For example, the scientific staff initially led by Henry on a variety of increasingly effective scientific ventures in cell Erlich and later by Tom Sninsky was instrumental in developing new biology and recombinant DNA research. Ron’s casual management DNA-based diagnostics. In general, employees from this era felt that style did not work well as the company grew. Now that Cetus was Cetus was a good place to work, with open exchange of information a publically held company, it became important to have a more and the opportunity to try out new ideas. In his 1996 book entitled traditional organizational structure. In 1982, Robert A. Fildes was Making PCR, the anthropologist Paul Rabinow described the early hired as president and Chief Operating Officer of Cetus, subsequently Cetus as “an improvisational space” (Rabinow 1996). replacing Ron as CEO as well. Ron became Chairman of the Board. Fildes was English and Ron was originally Canadian. In British and After Fildes was hired, Ron was glad to be relieved of the headaches Canadian companies, it is common to have non-executive chairmen of day-to-day management. He increasingly devoted his energies to who do not interfere in the day-to-day operations of the company. being a spokesman not only for Cetus but for the entire biotechnology industry. He traveled a lot and gave numerous lectures about the

October • November • December 2019 SIMB NEWS 121 feature promise of biotechnology. When environmentalists questioned White, and others. Getting definitive experimental data to support the the safety of specific recombinant DNA products or of the new concept took several years (Saiki et al, 1985; Mullis et al, 1986; Erlich, biotechnology in general, he would deliver a quote he attributed 1989). The first PCR patent application was filed on 28 March, 1985. to Mark Twain: “Like the music of Richard Wagner, it [biotechnology] Mr. Cycle, the first PCR machine was built at Cetus; years thereafter, is not as bad as it sounds.” The line usually got a laugh. [Note: we in 1987, Perkin Elmer introduced the first commercial thermal cycler. tracked down this quote and discovered that it was Edgar Wilson Nye, One extremely important hurdle was to find an enzyme that would a contemporary of Twain, who actually said, “They tell me Wagner’s survive the denaturing step inherent in the PRC technique. A literature music is better than it sounds.”) search revealed information about a thermophilic bacterium, Thermus aquaticus, with a heat stable DNA polymerase. A culture With Bob Fildes, Ron was a founding member of the Industrial was ordered from the American Type Culture Collection. Purification Biotechnology Association (now the Biotechnology Industry of the thermostable polymerase, now usually dubbed Taq pol, or Organization, or BIO), and served as its president for three years just plain Taq, was done by David Gelfand with the assistance of (1983-85). With his friend Vivian Moses, he co-edited a book entitled Susanne Stoffel. The enzyme performed even better than expected. Biotechnology: The Science and the Business (Moses and Cape, 1991). In the spring of 1986, Mullis was given a bonus of $10,000.00 for his During these same years, he served on many boards of directors breakthrough on the idea for PCR, while the other Cetus scientists including Scientific American Magazine, the Whitehead Institute, and received $1.00 for their contributions to the patent. Mullis left Cetus the Rockefeller University Council, the Board of Regents of the NIH in September 1986. National Library of Medicine and as a trustee at Princeton University. In addition, he was an adjunct professor of business administration Details about the PCR story, and the strong personalities involved in at the University of Pittsburg. its “reduction to practice,” have been described in Rabinow’s book on the subject (Rabinow 1996). The last chapter is notable for the POLYMERASE CHAIN REACTION (PCR) VS. generosity with which Erlich, Saiki, White and others give Mullis INTERLEUKIN 2 (IL 2)

Kary Mullis was hired by Cetus in 1979. Eventually he was assigned to a project in Henry Erlich’s group to develop DNA-based diagnostics Stanley Cohen and Ron Cape in 1989 that would utilize the power of the DNA complementary base pairing mechanism. Methods for denaturing and replicating DNA with synthetic primers had been known for a decade. Mullis later wrote more than one account of his intellectual epiphany. He posited that his fascination with computers familiarized him to the idea of iterative processes (Mullis 1990; Mullis 1997; Mullis 1998). It has become part of molecular biology lore to repeat the story of how of Mullis’ had an “Ah-Ha” moment about DNA amplification while driving his Honda Civic on California State Highway 128. Sadly, none of Mullis’ own accounts give much if any mention of the co-workers at Cetus who actually turned the PCR process into a workable technology. PCR would not have been successful without the tireless investigational efforts of colleagues. Mullis developed the idea; turning the concept into a workable tool took a large team of creative experimentalists. At first, Mullis was aided by a technician, Fred Faloona. He also got scientific and administrative support from Norman Arnheim, Henry Erlich, David Gelfand, Jeff Price, Randy Saiki, Stephen Scharf, Tom

122 SIMB NEWS www.simbhq.org feature credit for the DNA amplification concept. Their graciousness is in of Cetus’ patent rights to PCR, thermostable enzymes, and related sharp contrast to Mullis’ own accounts of the story in which he acts discoveries. What remained of Cetus was sold to Chiron Corporation. as if he developed PCR without outside help (Mullis, 1990; 1997; 1998). At Chiron, research on IL-2 was continued and just a year later, in 1992, the drug received approval from the Food and Drug Administration. It is doubtful that PCR could have been developed successfully in a university under traditional NSF or NIH funding mechanisms. On Ron, who was an exceptionally intelligent man, was acutely aware the other hand, because companies are not universities, they are that he had bet on the wrong biotechnology horse. He was quoted expected to produce profits. Shareholders want to make money. in the January 1992 issue of the Scientist: “Cetus made a gamble Fildes and Ron were under increasing pressure to generate a product. on IL-2 and lost, and everything [else] is secondary. Let’s face it, Cetus owned the patent on PCR but rather than focusing on the we had anticipated and had acted like an integrated company on potential of this breakthrough technology, the company rapidly expectations that turned out to be premature.” (Lehrman, 1992). entered into a complex series of licensing agreements with other AFTER CETUS, THE FINAL YEARS. companies. An HIV-ID detection system was licensed to Specialty and Pathology Institute in 1988; and then in 1989 Cetus developed Ron was major shareholder in Cetus so after the company was sold collaboration and licensing agreements with Hoffmann-LaRoche. to Chiron, and the patent rights to PCR were sold to Hoffman La Meanwhile, Cetus formed another joint venture with Perkin-Elmer Roche, he was an extremely rich man. However, for Ron, becoming so whereby Perkin-Elmer Cetus Instruments focused on instrument wealthy meant entering into a Faustian contract. Cetus Corporation, research, development, and manufacturing while Cetus produced the company he co-founded, and then led during much of its reagents such as Taq polymerase, many other DNA polymerases, and meteoritic twenty-year rise and fall, was no more. Much of Ron’s PCR reagent kits. The applications for PCR soon expanded beyond professional identity had been wrapped up in the company. Not only human diagnostics, into veterinary diagnostics, forensic applications, did he have had to abandon his dream of Cetus growing into a fully and numerous unforeseen basic uses in applied science and basic integrated pharmaceutical company, he felt a personal responsibility research (Daniell 1991 & 1994). for having let down his former employees. After the demise of Cetus, Ron continued to work as an advocate of the biotechnology industry In retrospect, it seems clear that Fildes and Ron were blind to their but he no longer projected his former passionate involvement. He most valuable asset and did not capitalize on the enormous promise of jokingly called himself “a yester person” while investing in, and/or PCR. Instead, they tried to turn Cetus into a traditional pharmaceutical serving on the boards of several new privately and publically held company. The major resources of the company were directed towards companies including Darwin, EntreMed Inc., Caprion, Inc., Neugenesis using recombinant DNA processes to produce biologicals such as Corp., and others. interleukins and interferons. For example, one major project was on beta interferon in conjunction with Triton Biosciences. The drug was On a personal level, Ron often preferred isolation and eschewed supposed to find use as a broad spectrum anticancer agent, but did social functions where there was a lot of glad-handing. His hobbies not meet expectations. (Later, beta interferon was found efficacious were similarly solitary. He loved to fly (he had a pilot’s license), to in treating multiple sclerosis and is now sold by Bayer Health Care as ski, and to travel to places where he could view solar eclipses. He Betaseron.) Another project focused on interleukin-2 (IL-2). Although delighted in Chinese food, the music of Gilbert and Sullivan, and IL-2 had not gained regulatory acceptance, nor had it proven its giving support to the San Francisco opera. broad-scale clinical efficacy, the company invested over one hundred He loved his family and was proud of the academic successes of million dollars into developing facilities for its production and hired a his daughters. During the last years of his life, he was afflicted with large marketing staff. In July 1990, when the FDA did not approve IL-2, a neurological illness that shrank his formidable intellect and led the reckoning came fast. There was a major funding crisis at Cetus. to increasing physical and mental challenges with day–to-day life. A month later, Robert Fildes resigned, and Ron resumed his position as CEO. Simultaneously, 100 of the 950 Cetus staff workers were laid off. In December of 1991, Hoffman-LA Roche paid $330 million for all

October • November • December 2019 SIMB NEWS 123 feature

He met his diminishment with dignity under the loving care of his Depending on how you look at the story of Cetus Corporation, it was family. Moreover, until the end of his life, he took enormous personal either a great success or a great failure. Ron always believed that Cetus satisfaction in being an “elder statesman of biotechnology.” was an entrepreneurial experiment. The experiment produced PCR, without a doubt one of the most transformative technologies to have Ron is survived by his brother Michael; his wife Libi (nee Pollock); his emerged in the late 20th century. Moreover, the pioneering business daughters, Jacqueline and Julie; and six grandchildren, Sammie, Alec. strategies Cetus management used to raise money have since Seth, Tory, Ali, and Zach. He is remembered by the biotechnology become common within the biotech industry. Cetus Corporation community for his vision and his unwavering belief that basic helped change industrial microbiology into the discipline we know research could be turned into unforeseen and profitable biological today. Ã products. His willingness to gamble on the economic potential of molecular biology helped transform industrial microbiology and About the authors: Joan Wennstrom Bennett is a created the prototype for the modern biotechnology company. He Distinguished Professor of Plant Biology at Rutgers moved comfortably in the zone between basic and applied science; University, New Brunswick, New Jersey and a Past similarly, he was at ease in both the laboratory and the boardroom. President of SIM. Corresponding author. Email: bennett@ In many ways, he embodied the exhilarating early days of molecular sebs.rutgers.edu biotechnology. He was optimistic, cerebral, and willing to take big risks. He could see that fundamental research was the best route Ellen Daniell is former Director of Licensing, Roche to breakthroughs that, in turn, could be turned into profitable Molecular Systems, Alameda, California. applications in industry, agriculture, and medicine.

REFERENCES Daniell, E. 1991. Polymerase chain reaction: development of a novel technology in a corporate environment. In: Biotechnology. The Science and the Business (Chapter 11). Vivian Moses, V. and Cape, R. (eds.) Harwood Academic Publishers, London, pp. 145-151. Daniell, E. 1994. PCR in the marketplace. In: Mullis, K., Ferre, F., Gibbs, R.A. (eds.). The Polymerase Chain Reaction. Birkenuser, Boston, pp. 421-426. Erlich, H. (ed). 1989. PCR Technology: Principles and Applications for DNA Amplification. Stockton Press. Lehrman, S. 1992. Cetus: A Collision Course With Failure, The Scientist, Jan 1992. https://www.the-scientist.com/news/cetus-a-collision-course-with- failure-60308 Lueck, T. 1981 Cetus in record offering; Market response is cool. New York Times March 7, 1981 https://www.nytimes.com/1981/03/07/business/cetus-in-record- offering-market-response-is-cool.html Moses, V. and Cape, R.E. (eds.) 1991. Biotechnology: the science and the business. Harwood Academic Publishers, London. Mullis, K. 1990. The unusual origin of the polymerase chain reaction. Sci Am 262:56–61, 64–65. Mullis, K. 1998. Dancing Naked in the Mind Field. Vintage Books, New York. Mullis, K.F. 1997. The polymerase chain reaction. Nobel Lectures, Chemistry 1991-1995, Editor Bo G. Malmström, World Scientific Publishing Co., Singapore. Mullis, K.F., Faloona, F., Scharf, S., Saiki, R., Horn, G. and Erlich, H. 1986. Specific enzymatic amplification of DNA in vitro: The polymerase chain reaction. Cold Spring Harbor Symposium in Quantitative Biology, 51:263–273. Rabinow, P. 1996. Making PCR: A Story of Biotechnology. University of Chicago Press, Chicago. Saiki, R., Scharf, S; Faloona, F; Mullis, K., Horn, G., Erlich, H., Arnheim, N. 1985. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science. 230: 1350–1354. doi:10.1126/science.2999980. Vettel, E.J. 2006. Biotech: The Countercultural Origins of an Industry. University of Pennsylvania Press, Philadelphia. Ward, C. 2015. First-Hand: A Real First-Hand Account of the Startup Phase of Cetus. Engineering and Technology History Wiki http://ethw.org/First-Hand:A_ Real_First-Hand_Account_of_the_Startup_Phase_of_Cetus (accessed Feb. 23, 2019).

124 SIMB NEWS www.simbhq.org meetings

3rd International Conference on Natural Product Discovery & Development in the Genomic Era

Wyndham San Diego Bayside Hotel January 12–16, 2020 San Diego, CA www.simbhq.org/np

A joint meeting with

October • November • December 2019 SIMB NEWS 125 meetings

Co-Chairs Monday, January 13

Brian Bachmann, USA I. Natural products of bacterial origin Nigel Mouncey, USA Conveners: Eung-Soo Kim, Inha University; Catherine Ryan, Ben Shen (Chair), USA University of British Columbia Yi Tang, USA II. Natural products of eukaryotic origin

Honorary Co-Chairs Conveners: Ikiro Abe, University of Tokyo; Sarah O’Connor, Dr. Richard Baltz, USA MIT Dr. Leonard Katz, USA Poster Session 2

Program Committee Tuesday, January 14

Ikuro Abe, Japan Rolf Müller, Germany III. Novel chemistry and enzymology of natural Gregory Challis, UK Anne Osbourn, UK products Tohru Dairi, Japan Frank Petersen, Switzerland Stefano Donadio, Italy Catherine Ryan, Canada Conveners: Greg Challis, University of Warwick; Bo Li, Edmund Graziani, USA Renxiang Tan, China University of North Carolina Donald Hahn, USA Steven Van Lanen, USA IV. Natural product enzymes as biocatalysts Jo Handelsman, USA Yeo Joon Yoon, Korea Nancy Keller, USA Wenjun Zhang, USA Conveners: Brad Moore, USCD Scripps; Allison Narayan, Eung-Soo Kim, Korea University of Michigan Wen Liu, China Nathan Magarvey, Canada Free evening Speakers Wednesday, January 15

Keynote Speaker: Jon Clardy, Harvard University V. Enabling technologies for natural products Banquet Speaker: Bill Fenical, Scripps/UCSD Conveners: Nigel Mouncey, JGI and Nathan Magarvey, McMaster University Meeting Schedule VI. Natural products for new targets and biology

Sunday, January 12 Conveners: Brian Bachmann, Vanderbilt University; Wenjun Zhang, University of California-Berkeley 12:00 noon Registration 4:45–6:00 pm Keynote Lecture Banquet and lecture 6:00–8:00 pm Poster Session 1 and Reception Thursday, January 16

VII. Natural product drug discovery and development

Conveners: Rolf Mueller, Saarland University; Carole Bewley, NIH

Adjourn

126 SIMB NEWS www.simbhq.org meetings

42nd Symposium on Biomaterials, Fuels & Chemicals

Astor Crowne Place April 26–29, 2020 New Orleans, LA www.simbhq.org/sbfc

2020 Chair »» Rapid Fire poster slam Claus Felby, Novo Nordisk Foundation Students

Co-Chair: Scott Baker, PNNL Apply now for SIMB Diversity Travel award and Student Oral or Poster Presentation awards Past Chair: Seema Singh, SNL

»» 12 Oral sessions Registration opens December 2019 »» 2 Poster sessions Exhibit prospectus available December »» 2 special topic sessions featuring IEA Task 39 updates and 2019 Global Research Consortia »» Student oral presentation session

October • November • December 2019 SIMB NEWS 127 meetings

SIMB 70th Annual Meeting & Exhibition 2020

Hyatt Regency San Francisco August 9–12, 2020 at the Embarcadero www.simbhq.org/annual San Francisco, CA

Call for Abstracts: Exhibit prospectus available now

Now open Student travel awards

2020 Program Chair Submit your abstract now for consideration: Adam Guss, Oak Ridge National Laboratory »» Poster presentations Workshop: Fermentation Basics »» Oral session »» Diversity August 9, 2020

128 SIMB NEWS www.simbhq.org meetings

Announcing: Industrial Microbiology Meets Microbiome (IMMM) 2020

November 8–10, 2020 San Diego, CA www.simbhq.org/immm

Three days of sessions, plenary Planning Committee talks, poster session and »» Noel Fong, Nucelis networking receptions »» Edan Hosking, Neogen »» Xiaxia “Nina” Lin, University of Michigan Tabletop exhibits available »» Mary Lipton, PNNL Contact [email protected] »» Trent Northen-JBI/LBL »» Steve Van Dien, Persephone Biome Chairs:

»» Yoram Barak, BASF »» George Garrity, Michigan State Univ »» Debbie Yaver, Novozymes

October • November • December 2019 SIMB NEWS 129 meetings

Topic Areas

1. Microbiomes in agriculture- crops

»» Soil microbiome analytics »» From soil/foliar ecology to predictive plant health, yield, pest control etc. »» New trends in community engineering in agriculture »» Biofertilizers 2. Microbiomes in animal health- probiotics

»» From targeted single microbes to cultured communities »» Use of probiotics to offset antibiotic use for growth »» New trends in microbiome driven solutions for animal health 3. Microbiomes in household care

»» New trends in microbiome for the built environment »» Applications of microbiome solutions for household care 4. Microbiomes in personal care

»» New trends in microbiome research for personal care »» Microbiome discovery for new personal care products »» Microbiome solutions for personal care »» The microbial ecology of personal care – challenges and opportunities in tools development 5. Microbiome in nutrition and health

»» From targeted single microbes to cultured communities »» The gut microbiota organs axes »» The nutrition gut-microbiome interplay »» New trends in microbiome for nutrition & Health research »» 6. Analysis tools and methods for microbiome studies

130 SIMB NEWS www.simbhq.org www.simbhq.org book review

by Elisabeth Elder

The Poison Squad: One Chemist’s Single-Minded Crusade for Food Safety at the Turn of the Twentieth Century Deborah Blum 2019 ISBN 9781594205149 (hardcover) ISBN 5780525560289 (ebook) Penguin Press, New York, New York

Spoiler Alert! This book is very different from the books recently reviewed on Dr. Harvey Washington Wiley, a chemist by training, who moved from in SIMB News. You may be familiar with Deborah Blum through her Purdue University in 1883 to be the Chief Chemist at the United States reputation as an historian, a scientist, and an author of multiple books. The Department of Agriculture (USDA). Under Wiley’s direction the USDA began one reviewed here is The Poison Squad. This is her most recent book which a campaign to develop food safety and to protect consumers. Within the supports and expands her reputation. campaign were many battles with producers, importers, wholesalers, and retailers as well as many people within the USDA plus state and federal This book covers food safety in the late nineteenth and early twentieth governments including several Presidents. There were questionable centuries. Reading this book made me realize how lucky my family was. We studies using young men, known as the Poison Squad, to determine the never questioned food safety especially since the milk and butter, much health impacts for the “preservatives” which were also used in embalming of the meat, and most of the vegetables came from neighbors’ farms. The and cleaning. Support for Wiley’s campaign came from some expected foods, often used in payment of medical bills for the farmers and their sources such as Fannie Farmer, known for her cookbooks and her work to families, came directly into our home without any processing. The eggs had ensure the safety of food as well as Henry J. Heinz of ketchup fame. Not been laid the day of delivery. The milk was “whole” meaning none of the all ketchup-like condiments were anywhere close to the Heinz product! cream had been removed and it was frequently still warm from the cow. More unexpected support came from Upton Sinclair, author of The Jungle. The milk separated into layers in the refrigerator. There was no adulteration Activists, journalists, women’s groups, and scientists were strong advocates of the milk such as addition of water or chalk as had occurred many years of Wiley’s work which is the major focus of Blum’s book. previously. Lard and oleomargarine were never provided in place of butter. There was never formaldehyde in the meat or milk. No borax in the Once you’ve started reading The Poison Squad, you will not be able to put butter. No copper sulfate in the home canned vegetables. These less than it down. The content and the writing style are fascinating. It is an intriguing wonderful preservatives and substitutions, along with salicylic acid in beer history of the development and passage of the Pure Food and Drug and wine, were common practices. Transitioning from the tainted foods Act in 1906 which was a culmination of thirty plus years of fighting and and beverages was a slow and difficult process that was largely dependent negotiating. The book will definitely prove to you how lucky we are.

132 SIMB NEWS www.simbhq.org members

SIMB Strategic Plan

Vision Goals To be the leading international professional society in industrial 1. Provide information to increase global knowledge, microbiology and biotechnology understanding, and application of industrial microbiology and biotechnology. Mission 2. Organize preeminent meetings in our core scientific disciplines. Empower our members and others to address current and 3. Publish the leading journal in industrial microbiology and future challenges facing humanity using industrial microbiology biotechnology. and biotechnology. 4. Promote and increase diversity in all aspects of the Society, Core values with membership open to anyone interested in our vision and Scientific excellence (innovation, rigor, multi-disciplinary science mission. and engineering, translational technology) 5. Enhance the value of membership in the Society for both Leadership (collaboration, continuity, advocacy) individual and corporate members. Diversity (promotion, inclusion, openness, internationality) 6 Offer educational/professional development opportunities for the membership and the general public. Responsibility (ethics, integrity, transparency, societal impact) 7. Communicate our activities and accomplishments in industrial Communication (education, information, outreach, microbiology and biotechnology to both the global scientific responsiveness) community and the general public. Passion for science (fun, inspiration) 8. Expand our global reach. 9. Ensure the financial and operational stability of the Society.

October • November • December 2019 SIMB NEWS 133 members Letter from SIMB President Jan Westpheling It is indeed an honor for me to serve as SIMB /president. I have been involved, in what was then SIM, since I was a graduate student and gave the first scientific presentation of my career at a SIM meeting. The Society has always provided a home for interdisciplinary research, outside-the-box thinking and the application of basic research to solve real world problems. For many of us with such interests, SIMB continues to be an intellectual home. From a personal perspective, the Society was particularly welcoming to me as a young scientist and as President I will focus on continuing that legacy. I encourage anyone, no matter what stage of career, who is interested in being part of SIMB activities to get involved and contact me directly if you need help navigating the system or finding the right contact. The future of the Society depends on you.

We have four terrific meetings scheduled this year. Recent Advances in Fermentation Technology (RAFT®) will be held in Ft Myers, Florida on October 27–30 at the Hyatt Regency Coconut Point Ft. Myers Bonita Springs, www.simbhq.org/raft. The 3rd International Conference on Natural Products Discovery and Development in the Genomic Era 2020 will be held in San Diego on January 12–16 at the Wyndham San Diego Bayside, www.simbhq.org/np. The 42nd Symposium on Biomaterials, Fuels and Chemicals (new name, same acronym) will be held in New Orleans on April 26–29 at the Astor Crowne Plaza New Orleans, www.simbhq.org/sbfc. Our Annual Meeting will be held in San Francisco on August 9–12 at the Hyatt Regency, www.simbhq.org/annual. I also want to announce a new meeting of the Society, Industrial Microbiology Meets Microbiome (IMMM) to be held for the first time in San Diego on November 8–10, 2020, at the Hotel Palomar. The most important mission of our Society is to provide outstanding scientific content in our meetings and publications. Thanks to the efforts of our outstanding program chairs, Tiffany Rau (RAFT®), Bin Shen (Natural Products), Claus Felby (SBFC), Adam Guss (Annual Meeting) and Debbie Yaver (IMMM), the content of these meetings will be outstanding. Please contact them if you have ideas to contribute or want to volunteer to help.

I am especially pleased to announce that the keynote speaker for our Annual Meeting in San Francisco will be Professor Jennifer Doudna, who has pioneered the development of CRSPR technology and its applications for biotechnology. CRSPR genome editing has revolutionized the ability to specifically modify genomes and its application to engineer everything from plants to microbes has opened a new era in biotechnology. I am thrilled that she will present the keynote.

We offer travel awards to our meetings, including Diversity Travel Awards and student awards for posters and presentations. We make a number of Society awards for scientific leadership, service and teaching and I encourage you to nominate outstanding individuals from your area of expertise. I especially ask that you reach out to young scientists for our Young Investigator Awards. As part of our service to members we have a career placement center and a booth at all our meetings and will help with the preparation of CVs and job applications. Please check out the SIMB website for information about all these activities.

I will be at all of this year’s meetings and I encourage you to find me and introduce yourself if I don’t already know you, get involved in SIMB, enjoy the venues and most importantly enjoy and learn from the scientific presentations. Jan Westpheling, SIMB President

134 SIMB NEWS www.simbhq.org members Society for Industrial Microbiology and Biotechnology 2019 Resolutions

1. To the 2018-2019 Officers of the Society: 5. To the Senior Editors: Dr. S.T. Bagley, Dr. R.H. Baltz, Dr. T.W. Jeffries, Dr. T.D. Leathers, Dr. M.J. Lopez Lopez, Dr. President Steve Van Dien, PhD, Persephone C.D. Maranas, Dr. S. Park, Dr. J.L. Revuelta, Dr. Ben Shen, Biome Dr. D.K. Solaiman, Dr. Y. Tang, Dr. E.J. Vandamme, Dr. X. Past President Debbie Yaver, PhD, Novozymes (Jerry) Yang, Dr. H. Zhao, and to Springer for producing President-elect Janet Westpheling, PhD, a distinguished international journal of industrial University of Georgia microbiology and biotechnology. Secretary 2018-2021 Elisabeth Elder, PhD, Georgia 6. To Melanie Mormile PhD, Editor-in-Chief of SIMB State University News, Stephanie Gleason, PhD, Kristien Mortelmans, Treasurer 2017-2020 Laura Jarboe, PhD, Iowa State PhD, Vanessa Nepomuceno, PhD and Elisabeth Elder, University PhD, Associate Editors; and to Ms. Katherine Devins, Directors Joy Doran Peterson, PhD, Production Coordinator, for providing the membership University of Georgia with an attractive and professional publication throughout the year. Thomas Klasson, PhD, USDA-ARS- SRRC 7. To Mr. Bob Berger, Exhibits and Placement Chair, and Tiffany Rau, PhD SIMB official photographer, for his efforts throughout Michael Resch, PhD, NREL the year on behalf of the Society. Executive Director Christine Lowe, SIMB 8. To the Society’s committee chairs and committee members for their dedicated service to the Society. 2. To the outgoing members of the Board for their dedicated service: 9. To Joy Doran Peterson, PhD, SIMB Education Committee chair who provided excellent service Debbie Yaver, PhD and dedication to the organization of the Society’s Joy Doran Peterson, PhD workshops.

Thomas Klasson, PhD 10. To Ms. Debbie Chadick, Mrs. Ann Kulback and Doug Eveleigh, PhD, for maintaining the Society archives and 3. To the incoming members of the Board for 2019-2020, the Society exhibit. beginning July 24, 2019: 11. To the SIMB Headquarters Office Staff: Ms. Suzi President Janet Westpheling, PhD Citrenbaum, Web Manager; Ms. Jennifer Johnson, Director of Member Services; Ms. Espie Montesa, President-elect Steve Decker, PhD, NREL Accountant; Ms. Tina Hockaday, Meeting Coordinator, Directors Katy Kao, PhD, San Jose State Ms. Katherine Devins, Production Coordinator, Ms. University Jen Ruben, Marketing and Mr. Todd Carlisle, IT and Priti Pharyka, PhD, Genomatica networking, for their devotion and dedicated service to the Society. 4. To Dr. Ramon Gonzalez, Editor-in-Chief of the Journal of Industrial Microbiology and Biotechnology, for These Resolutions are respectfully submitted. outstanding editorial services during the year. Christine Lowe, Executive Director October 2019

October • November • December 2019 SIMB NEWS 135 members Annual Meeting Resolutions Be it resolved that we, the members of the Society for 11. To the 2019 SIMB Fellowship awardees: Industrial Microbiology and Biotechnology, express our Scott E. Baker, PhD sincere appreciation and thanks to the following people Leonard Katz, PhD and organizations who have made the 2019 Annual Tom Kelleher, PhD Meeting an outstanding success: 12. We congratulate the 2019 Quarter Century Club 1. To the Headquarters Office staff for handling logistics, inductees: local arrangements and social activities for the annual meeting. F.C. Thomas Allnutt, PhD Robert Gerger, PhD 2. To the Marriott Wardman Park Hotel for providing us Jeff Lodge, PhD with excellent hotel services during the meeting. Jack Saddler, PhD 3. To the Annual Meeting program chair Katy Kao, San Badal Saha, PhD Jose State University, and the 2019 program committee Thomas West, PhD for organizing an outstanding program. 13 We congratulate the 2019 Diversity Travel Awardees: 4. To Mark Berge, PhD for presenting the workshop Andrew Flores “Fermentation Basics” and to Claes Gustafsson, Floricel Gonzalez PhD, ATUM and Shawn Szyjka, PhD, Zymergen, for presenting the workshop “Genome Editing: CRISPR/Cas9 14. We congratulate the 2019 Carol D. Litchfield student transposons and other tools.” oral and poster presentation winners.

5. To the session conveners for developing and leading 15 To the following organizations for their sponsorship excellent technical sessions and to the invited speakers of the 2019 Annual Meeting: and poster presenters for their contributions. BASF 6. To Jo Handelsman, PhD, for presenting the Keynote Cargill lecture “Chemical diversity from the soil microbiome.” Conagen 7. To Prof. Jeong Kug Lee tor presenting the Korean Codexis Society for Microbiology and Biotechnology plenary Novozymes lecture “Biosynthesis of (bacterio)chlorophyll and the Pivot Bio biotechnological application of the chromatophore ManusBio membrane vesicles.” Infors USA 8. To Yi Tang, PhD, UCLA, recipient of the Charles Thom Frances Templeton Fund Award, for his outstanding research contributions to industrial and applied microbiology, and for presenting the Thom Award Lecture.

9 To Tim Davies, PhD, Corteva, Charles Porter Award recipient, for his long, dedicated service to the Society.

10. To Spiros N. Agathos, PhD, Yachay Tech, recipient of the Waksman Outstanding Teaching Award.

136 SIMB NEWS www.simbhq.org members

16. To the commercial exhibitors and their 18. To Run Coordinator Elisabeth Elder, PhD and for representatives who recognize the value of their continuing the 5K Fun Run-Walk tradition. presence at the SIMB Annual Meeting: 19. To Ms. Jennifer Johnson, Ms. Tina Hockaday and Angel Yeast Mrs. Ann Kulback, for handling registration and other Applikon Biotechnology, Inc. administrative duties at the meeting. aquila Biolabs GmbH These Resolutions are respectfully submitted. Archer Daniels Midland Biolog, Inc. Christine Lowe, Executive Director Bio-Technical Resources October 2019 BugLab, LLC Chemglass Life Science DOE Agile BioFoundry DOE Systems Biology Knowledgebase (KBase) Eppendorf Gardner Industries Global BioIngredients, Inc. Hamilton Company Hiden Analytical, Inc. Igenbio, Inc. Infors USA Kuhner Shaker, Inc. Lallemand, Inc. m2p-labs, Inc. MP Biomedicals, LLC Procelys Process Analyzers by Schneider Electric Sartorius Stedium Biotech SIMB Archives

17. To the advertisers and publishers for their support of the Annual Meeting:

Genetic Engineering News Infors USA

October • November • December 2019 SIMB NEWS 137 members

2020 Call for SIMB Award Nominations

Nominations are now being accepted for 2020 SIMB Awards which will be presented at the 2020 SIMB Annual Meeting, August 9-12 at the Hyatt Regency San Francisco.

See www.simbhq.org/about/awards for forms and award descriptions.

All awards will be vetted through the SIMB Awards and Honors Committee and presented to the board of directors for approval.

Check the website for deadline dates.

–– Charles Thom Award Other SIMB Awards –– Charles Porter Award Diversity Travel Awards – offered to US students. –– SIMB Fellowship Apply via the abstract submission website and –– Young Investigator Award complete the required application forms. –– Waksman Outstanding Teaching Award Carol D. Litchfield Student Oral and Poster Presentation Awards – offered to all student presenters. Apply via the abstract submission website. Students will be judged onsite at the annual meeting.

138 SIMB NEWS www.simbhq.org members

Jan Westpheling, President University of Georgia

Steve Van Dien, Past President Persephone Biome

Steve Decker, President-elect NREL

Laura Jarboe, Treasurer Iowa State University

Elisabeth Elder, Secretary Georgia Southwestern State University

Directors Katy Kao, San Jose State University

Priti Pharyka,

2019–2020 Directors of Board SIMB Genomatica.

Tiffany Rau, BioProcess Technology Consultants

Michael Resch, NREL

October • November • December 2019 SIMB NEWS 139 members

2020 SIMB Election for Board of Directors

The SIMB Election for positions on the Board of Directors will commence March 2, 2020. The election will end at noon EST on March 31, 2020, and members must join/renew by March 30, 2020, by noon EST to be eligible to vote.

Current members for 2020 will receive login instructions for accessing the voting module.

The first step in the election process is the identification of the Nominations Committee (NC ) consisting of the chair and least two members. The committee members are approved by the Board and serve only for the current year and cannot be reappointed within a three-year period. The NC proposes a slate of candidates (usually at least two candidates for each position) with input from the membership. The candidates must be current SIMB members with a demonstrated interest and involvement in SIMB. Upon acceptance of the nomination, the NC informs the candidates of the duties and responsibilities required by each position. In addition to the NC, candidates can be identified via Article 5, Section 4 in the SIMB Constitution using a petition process.

The final slate of candidates is due to the president by the first board meeting during the annual meeting. Candidates must submit a biography and photograph by October 15, 2020, for publication in the October-December issue of SIMB News and for posting on the website. After voting ends, the Election Committee, consisting of a minimum of two SIMB members, receives access to the voting module and certifies counts from online voting, as well as any paper ballots previously requested and postmarked no later than the deadline date for electronic voting ballots, and delivers the results to the SIMB President and SIMB Secretary for announcement.

The election process and ballots are available for inspection for at least 30 days following the annual meeting. Ballots and records are destroyed six months after the election (unless otherwise directed by the Board) and final tabulation of the votes is preserved.

140 SIMB NEWS www.simbhq.org members Candidate for President Noel M. Fong A yeast geneticist –– Former President of the Northern California local by training, Noel is chapter Director of Strain –– Actively working to revive the Southern California Development at Nucelis chapter. LLC, where she does –– Reviewer for the Journal of Industrial Microbiology and Biotechnology and Enzyme and Microbial Metabolic Engineering Technology. for construction of microbial strains I am dedicated to service to the Society, and would be making custom oils and honored to be your President. As a board member, I promote: metabolites in fungi and 1. Career development at two key junctures: bacteria. She thrives in startup companies, having worked at Zymogenetics and early Chiron. She is broadly trained, having (a) Preparing students for the transition from school to 2020 SIMB Election for Board of Directors received her Ph.D. in Microbiology and M.S. in Food Science industrial careers, especially that first job. This entails from U.C. Davis, and her B.S. in Chemistry and Biophysics preparing students to get the kind of experience from U.C. Berkeley. She did her postdoc at the University of industry values while still in school, and (b) Working Michigan Medical School/Parke-Davis in insulin signaling with mid-to-late career individuals to expand and for diabetes, and trained at the Seattle Culinary Academy showcase their skills and explore options. in pastry (as bread baking IS an application of yeast!). 2. Ensure the ongoing financial health of SIMB by (a) I first learned of SIMB (then SIM) when I was a Research growing the membership – individual and corporate, Associate at my first job at Chiron. Having been to other (b) increasing meeting attendance and sponsorship, scientific meetings before, I quickly saw that SIM was unique and (c) (re)positioning JIMB to maintain prominence and in that it offered the same scientific rigor, but coupled with profitability in this era of OpenSource publishing. reduction to practice and a vision to practical applications 3. Cross fertilization with organizations with common interests in the future. Throughout my 30+ years as a member, to exchange ideas or forge collaborations. e.g. ASM, IFT SIMB has given me so much - opportunities to establish and ACS all touch upon different aspects of fermentation. personal and professional connections with colleagues in This also extends to our international counterparts. industry and academia who have guided my career, and a As President of the Northern California section, I had venue where I presented my work in person and in print. organized a Summit of local professional societies, where It is my professional ‘home,’ and I believe in giving back: representatives from 30 groups gathered to network. –– Conference Chair for the 2018 General Meeting in Chicago 4. Ongoing evaluation of topics to cover at conferences. –– Program Committee for Fermentation for the last 10 This entails identification of emerging areas, and re- years balancing or recombining areas to reflect industry trends. –– Session Speaker –– Education committee member –– Diversity committee member

October • November • December 2019 SIMB NEWS 141 members Candidate for President Michael Resch Michael Resch earned his PhD in biochemistry and molecular biology from Colorado State University working on protein-DNA interactions in chromatin. Dr. Resch began his career at the National Renewable Energy Laboratory (NREL) in 2008 working on projects funded by industrial partnerships and the Department of Energy. His research focus now spans from biomass feedstock processing and conversion, CO2 utilization, low carbon ammonia production and other technologies to enable a future circular carbon economy.

Along with being a member of SIMB since 2008, Dr. Resch is also a member of American Chemical Society and has serves on the Journal of Biological Chemistry Editorial Board. He has contributed to the Symposium on Biotechnology for Fuels and Chemicals and SIMB Annual Meetings as a session convener/chair, and invited speaker, a member of the SIMB Annual Meeting Biocatalysts Program Committee and was elected to the SIMB Board of Directors in 2017.

As an SIMB Board Member Michael has been working to improve the conference experience for sponsors, organizers and attendees by updating the on-line registration system and initiating a more user-friendly smart phone program viewer. He is also dedicated to keeping SIMB meetings and publications subscribed by high impact academic and industrial science. Michael has pushed to streamline the meeting structures into two annual meetings and specialty meetings. Also, he would like keep the meetings programs flexible allowing integration of novel scientific topics and encourage young investigators to organize sessions alongside scientific pioneers. All of this is in the hope to enable an atmosphere where international academic, industrial and government stakeholders can develop well-rounded meetings with diverse viewpoints.

Webpage: http://www.nrel.gov/bioenergy/bios/michael-resch.html

142 SIMB NEWS www.simbhq.org members Candidate for Treasurer Steven Singer I am a Senior Scientist at Lawrence Berkeley National Laboratory and Director of Microbial and Enzyme Discovery at the Joint BioEnergy Institute in Emeryville, CA. My group studies ways to convert plants, methane and carbon dioxide to biofuels and bioproducts. I have served on the Organizing Committee for three annual meetings and was chair of the Environmental Section for the 2017 meeting in Denver. I have also served on the Nominations Committee in 2017. As Treasurer, I will work with the President and Board of Directors to ensure that the Society remains on a solid financial footing and will pursue new sources of revenue. I think the Society provides a unique perspective on microbiology that is relevant to scientists and engineers involved in both fundamental and applied research, and will use my role as Treasurer to expand its membership.

October • November • December 2019 SIMB NEWS 143 members Candidate for Treasurer Laura Jarboe Laura Jarboe is an Associate Professor of Chemical and Biological Engineering at Iowa State University and former Chair of ISU’s Interdepartmental Microbiology Graduate program. Her research program generally focuses on engineering robust microbial cell factories in order to increase the economic viability of bio- production platforms, often involving engineering of the cell membrane and strategies to improve utilization of biomass-derived monomers. Jarboe’s lab is also involved in the characterization of microbial attachment and microbial utilization of anhydrosugars. Laura has been a member of the SIMB Diversity committee since 2014 and is completing a first term as SIMB Treasurer.

144 SIMB NEWS www.simbhq.org members Candidate for Board of Directors Raj Boopathy Dr. Raj Boopathy of Pure and Applied Chemistry (IUPAC), Society for Industrial is an Alcee Fortier Microbiology and Biotechnology (SIMB) and the International Distinguished Service Forum on Bioprocessing (IFBioP). Dr Raj Boopathy was Professor of biological selected as a Fulbright Senior Scholar Specialist to visit various sciences at the Nicholls countries for next five years by the US State Department State University, USA. and he recently visited Malaysia and Indonesia as a Fulbright He received the Jerry Specialist. Dr. Boopathy received Dr. Waksman Award Ledet Foundation from SIMB for his contribution in Microbiology Education Endowed Professorship in 2017. Dr. Boopathy is the recipient of the World Class in Environmental Biology Professor (WCP) award from the Government of Indonesia. in 2002 and John Brady Endowed Professorship in 2012. In 2008, Dr. Raj Boopathy Specific SIMB Activities and Services: received the Nicholls State University’s Presidential Award for –– SIMB Annual Meeting Program committee member Teaching Excellence. He has more than 30 years of research (2015 to 2018) experience in the area of bioremediation and bio-processing. –– SIMB Annual Meeting Environmental Session Chair His research involves bioremediation of hazardous chemicals (2016-2018) including oil spills and explosives, biological treatment of –– SIMB Annual Meeting Program Chair for wastewater, antibiotic resistance genes in the environment, Environmental Session for 2018 Meeting. and bio-ethanol production. He has published 167 research –– Invited as a Speaker at the 2015 and 2016 Annual papers in peer- reviewed journals and 17 book chapters. Meeting He edited one book. His research work has been cited –– Elected as SIMB Fellow in 2016 more than 7,000 times with h-index of 47. Dr.Raj Boopathy –– Received Waksman Award from SIMB in 2017 reviewed research grants for National Science Foundation, Department of Defense, US Environmental Protection Agency, –– Reviewed Research Papers for the Journal of Department of Energy, and numerous private agencies and Industrial Microbiology and Biotechnology foreign governments including South Africa, Switzerland, –– Guest Editor of the Special Issue of Journal of Indonesia, and Israel. He is the editor of International journal Industrial Microbiology and Biotechnology -2019 of Biodeterioration and Biodegradation (IBB), Current Pollution –– Served as Poster Judge at the SIMB Annual Meeting Reports, and the Journal of Applied Sciences (Section, for the past three years Environmental and Sustainable Science and Technology). –– Committee Member of Awards/Honors He also serves as a senior editor of the Journal, Renewable –– Committee Member of Membership Committee Bioresources and is on the Editorial Boards of various – International journals including Bioresource Technology and – SIMB 2019 Annual Meeting- Students/Posters Committee the International Journal of Soil and Sediment Contamination. Dr. Raj Boopathy received Fulbright scholarship and spent six If I am elected as a director I will continue to serve SIMB on months teaching and conducting research at the Institute various activities mentioned above and I will focus my energy of Technology (ITB) in Bandung, Indonesia in 2007. He also in increasing the SIMB membership and enhance our society’s received European Union-US biotechnology Fellowship and visibility in Asian and Latin American Countries. I am asking Leverhulme commonwealth fellowship. He has been elected your vote to elect me as a member of the board of directors. as a Fellow of various societies including International Union

October • November • December 2019 SIMB NEWS 145 members Candidate for Board of Directors Robert S. Donofrio Dr. Robert S. Donofrio obtained his doctoral degree in Microbiology from holds the position Michigan Technological University in May of 2009, under of Vice President of the guidance of past SIMB President Dr. Susan T. Bagley. Food Safety Research Dr. Donofrio has authored dozens of publications and Development at for peer reviewed journals (including the Journal of Neogen. He joined Industrial Microbiology and Biotechnology), trade journals Neogen in February of and training materials. In addition to the Society of 2016. He is responsible Industrial Microbiology and Biotechnology (SIMB), he is for the strategic vision, a full member of the International Association for Food resource management Protection (IAFP), Association of Analytical Communities and coordination of product development activities for (AOAC), and American Society for Microbiology (ASM). the following laboratory groups: Immunodiagnostics, Biochemistry, Neogen Culture Media, Molecular biology, Dr. Donofrio has been involved with SIMB throughout his Pathogen Detection and General Microbiology. Dr. Donofrio entire professional career, starting as a poster presenter at also oversees the Neogen Validation laboratory which is the Annual Meeting in 1997 and most recently serving as responsible for performing internal product validation Program Chair for the 2018 Recent Advances in Microbial and coordinating third party product certification and Control Conference. Over those 20 years, Dr. Donofrio was the approval through groups such as AOAC, AFNOR, Health organizer for the Annual Meeting poster session for 10 years, Canada and MicroVal. Dr. Donofrio is also responsible for authored multiple posters, presented talks and served as establishing key collaborations with university and private session chair for several Annual Meetings and RAMC meetings, research centers as well as evaluating novel technologies for was his company’s primary representative for SIMB corporate potential integration into Neogen’s product portfolio. Prior sponsorship while at NSF International and Neogen and to Neogen, Dr. Donofrio spent 16 years at NSF International, even served as an exhibitor at various SIMB conferences. He a public health and safety company with primary functions is most proud of the two terms he served on the SIMB Board in standards authoring and third party, independent auditing of Directors as Secretary, cycling off in the Summer of 2018. and testing / claim verification. During his tenure at NSF, Dr. Donofrio served as the Director of the Microbiology and Dr. Donofrio’s reason for running for the position of Director, Molecular Biology for over a decade and then as Director other than for a love and respect of the Society and of the Applied Research Center for his final 3 years. He was passion for microbiology, is to bring the representation and awarded the NSF Star Employee Award in March of 2001 perspective from the food, cosmetics and water diagnostic (was nominated for the same award in 2008) and guided sectors and third party commercial testing lab sector to his laboratory to the 2006 NSF Team of the Year Award. SIMB. This includes expertise in commercial method/kit development (bridging the development gap between Dr. Donofrio obtained his B.S. in Biology from the academia and industry and adoption of novel technologies), University of Dayton in 1994 and his M.S. in Environmental method validation, standard development, regulatory Microbiology from Duquesne University in 1996, where compliance, and quality control implementations. he was named Graduate Student of the Year. Dr. Donofrio

146 SIMB NEWS www.simbhq.org calendar Meetings & Continuing Education

SIMB Meetings

January 12-16, 2020 3rd International Conference on Wyndham San Diego Bayside Hotel Natural Products Discovery and San Diego, CA Development in the Genomic Era www.simbhq.org/np

April 26-29, 2020 42nd Symposium on Biomaterials, Astor Crowne Plaza Fuels and Chemicals New Orleans, LA www.simbhq.org/sbfc

August 9-12, 2020 SIMB 70th Annual Meeting and Hyatt Regency San Francisco Exhibition San Francisco, CA www.simbhq.org/annual

November 8–10, 2020 Industrial Microbiology Meets San Diego, CA Microbiome (IMMM( www.simbhq.org/immm

Other Industry Meetings

February 24-25, 2020 24th Global Congress on Biotechnology London, UK https://biotechnology. insightconfereces.com

April 21-23, 2020 6th Annual Translational Microbiome Boston, MA Conference https://microbiomeconference.com

April 23-24, 2020 Advances in Biomass, Biofuels and New York, NY Bioenergy https://www.clocate.com/ conference/advances-in-biomass- and-bioenergy/86275

June 22-23, 2020 8th International Congress & Expo on Toronto, Canada Biotechnology and Bioengineering https://scientificfederation.com/ biotechnology-2020

October • November • December 2019 SIMB NEWS 147 committee corner SIMB Committees 2019–2020

Committee Chair Email Term Members Staff Liason expires Annual Meeting 2020 Adam Guss [email protected] 2020 See Program Committee Tina Hockaday, Chris Lowe Archives Debbie Chadick [email protected] 2022 Paul Cino, Doug Eveleigh, Jennifer Johnson Ann Kulback Awards/Honors Mahendra Jain [email protected] 2021 Susan Bagley, Kathy Asleson Chris Lowe Dundon, Tom Jeffries, Raj Boopathy Audit & Investment Jeff Schwartz [email protected] 2020 Dick Baltz Chris Lowe, Advisory Espie Montesa Herb Ward [email protected] 2020 Diversity Sara Shields-Menard [email protected] 2021 Noel Fong, Laura Jarboe, Jennifer Johnson, Sheena Becker, Chris Lowe Felipe Sarmiento [email protected] 2020 Vanessa Neopmuceno

Education and Katy Kao [email protected] 2020 Mark Berge, Noel Fong, Chris Lowe Outreach Laura Jarboe, Steve Van Dien, Katy Watts Elections Kristien Mortelmans [email protected] 2019 Badal Saha Jennifer Johnson Ethics Committee Susan Bagley [email protected] 2022 Scott Baker, Neal Connors Exhibits Elisabeth Elder [email protected] 2021 Lisa Soto, Bob Berger, Tina Hockaday Abbie More Finance Laura Jarboe [email protected] 2020 Finance Committee Chris Lowe Meeting Sites Chris Lowe [email protected] - BOD and meeting chairs Corporate Member Andreas Schirmer [email protected] 2020 Jonathan Sheridan Jennifer Johnson Outreach Yoram Barak [email protected] 2020

Membership- Stephanie Gleason [email protected] 2021 Laura Jarboe, Thomas Jennifer Johnson individual Klasson, Steve Van Dien Nominations Debbie Yaver [email protected] 2020 Chris Lowe Placement Bob Berger [email protected] 2020 Sara Dorman Jennifer Johnson Planning Steve Decker [email protected] 2020 Chris Lowe Publications Nigel Mouncey [email protected] 2020 George Garrity, Herb Ward Chris Lowe JIMB Ramon Gonzalez [email protected] 2020 JIMB Editors SIMB Melanie Mormile [email protected] 2024 Kristien Mortelmans, Katherine Devins News Elisabeth Elder, Vanessa Neopmuceno Presidential Ad Hoc Committees-expire 2020 International Susanne Kleff [email protected] 2019 Scott Baker, Tim Davies, Outreach George Garrity, Peter Punt, Thomas Klasson, Erick Vandamme, Michael Resch

148 SIMB NEWS www.simbhq.org committee corner

Special Conferences Term NP 2020 Ben Shen [email protected] 2020 BrianBachmann [email protected] 2020 Nigel Mouncey [email protected] 2020 Yi Tang [email protected] 2020 SBFC 2020 Claus Felby [email protected] 2021 Scott Baker [email protected] 2022 Seema Singh [email protected] 2019 IMMM 2020 Debbie Yaver [email protected] 2022 Yoram Barak [email protected] 2022 George Garrity [email protected] 2022

October • November • December 2019 SIMB NEWS 149 Become a SIMB Corporate Member

Member Benefits: • Meeting Registration Discounts (Each $500 voucher is good toward any SIMB meeting registration fee) Silver - 1 $500 voucher Gold – 2 vouchers Diamond - 3 vouchers Other Current Benefits: • Recognition and corporate profile in SIMB News • Discounted exhibit booths • Discounted advertisements and job postings 2020 SIMB Corporate Membership Application

Choose Your Corporate Level:

 Institutional Level $700  Bronze Level $500  Silver Level $1000  Gold Level $1,500  Diamond Level $2,500

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¨¨ Fermentation (non-food or beverage) ¨¨ Microbiome Research/ ¨¨ Systems Biology, Omics, Computational ¨¨ Cell Culture Metagenomic Biology, and Bioinformatics ¨¨ Metabolic Engineering/Strain Engineering ¨¨ Microbial Control/Biocides and ¨¨ Process Development & Biochemical ¨¨ Molecular Biology/Synthetic Biology Tools Disinfectants/Clinical & Medical Engineering Development Microbiology ¨¨ Agriculture/Plant Biology ¨¨ Biocatalysis/Enzymology/Biochemistry/Enzyme ¨¨ Environmental Microbiology/ ¨¨ Marine, Aquatic Biology & Algae Engineering Bioremediation ¨¨ Mycology/Fungal Biotechnology ¨¨ Biomass Pretreatment, Deconstruction, and ¨¨ Food Microbiology and Safety ¨¨ Analytical Chemistry, QA/QC Conversion ¨¨ Brewing, Winemaking, and ¨¨ Regulatory Affairs, IP, and Sustainability ¨¨ Antibiotics/Secondary Metabolites/Natural Fermented Foods Products/Pharmaceuticals

Payment Authoring Officer who is to receive all billing

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Total Amount Enclosed $ ______Name:  Invoice my company  Check enclosed (payable to SIMB). Check must be drawn from a US bank. Title:  Charge to: ¡ Visa ¡ MC ¡ AMEX  Wire Transfer (Additional Fees Apply) Address:

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Society for Industrial Microbiology & Biotechnology • 3929 Old Lee Highway Suite 92A • Fairfax VA 22030-2421 Send Payment To: P: 703.691.3357 x23 • F: 703.691.7991 • E: [email protected] • www.simbhq.org

October • November • December 2019 SIMB NEWS 151 2020 SIMB Corporate Membership Application Company Representative who will receive Additional Company Representative membership including publications: (Gold and Diamond Level only)

¨ Please do not send me SIMB Please Select a Delivery ¨ Please do not send me SIMB Please Select a Delivery information via email Method for both JIMB and SIMB information via email Method for both JIMB and SIMB ¨ Please do not include me on News ¨ Please do not include me on News any SIMB mailing lists  SIMB News MAIL Print Copy any SIMB mailing lists  SIMB News MAIL Print Copy ¨ Please do not include my  SIMB News Online Access ONLY ¨ Please do not include my  SIMB News Online Access ONLY information in the SIMB online information in the SIMB online membership directory  JIMB MAIL Print Copy membership directory  JIMB MAIL Print Copy  JIMB Online Access ONLY  JIMB Online Access ONLY

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¨ Please do not send me SIMB Please Select a Delivery ¨ Please do not send me SIMB Please Select a Delivery information via email Method for both JIMB and SIMB information via email Method for both JIMB and SIMB ¨ Please do not include me on News ¨ Please do not include me on News any SIMB mailing lists  SIMB News MAIL Print Copy any SIMB mailing lists  SIMB News MAIL Print Copy ¨ Please do not include my  SIMB News Online Access ONLY ¨ Please do not include my  SIMB News Online Access ONLY information in the SIMB online information in the SIMB online membership directory  JIMB MAIL Print Copy membership directory  JIMB MAIL Print Copy  JIMB Online Access ONLY  JIMB Online Access ONLY

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152 SIMB NEWS www.simbhq.org

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