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Giant Gene Thieves Have You Renewed Your Membership for 2020? Vol. 18 / No. 10 / November 2019 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Giant gene thieves Have you renewed your membership for 2020? Together, we’ll continue to advocate for science, connect researchers around the world and build a bright future for biochemists and molecular biologists everywhere. Learn more at www.asbmb.org/membership CONTENTS NEWS FEATURES PERSPECTIVES 2 24 50 GIANT GENE THIEVES SERVICE BEYOND SCIENCE EDITOR’S NOTE ese viruses are changing what we know Weaving social innovation and scienti c It’s about time about structural and evolutionary biology methods for a bright future 3 32 MEMBER UPDATE MEET SEAN DAVIDSON 7 e JLR associate editor rethinks cholesterol NEW MEMBERS 9 24 YEAR OF (BIO)CHEMICAL ELEMENTS For November, it’s that smell of sulfur 10 NEWS Bacterial invasion may explain recurrent urinary tract infections 11 13 JOURNAL NEWS 11 Snug as a bug in the mud 50 13 Researchers clock DNA’s recovery time 14 Lack of sleep a ects fat metabolism 15 is protein makes antibody drugs work 16 From the journals 22 LIPID NEWS Phospholipids and innate immunity 32 2020 Award Winners … page 37 Ruth Kirschstein Diversity in Science Award: ASBMB Award for Exemplary Contributions to Lizabeth Allison Education: Paul Black Herbert Tabor Research Award: Kevin Campbell Bert and Natalie Vallee Award: Edward Dennis ASBMB–Merck Award: Manajit Hayer–Hartl Alice and C. C. Wang Award in Molecular Parasitology: Patricia Johnson Avanti Award in Lipids: Jean Schaff er Earl and Thressa Stadtman Young Scholar Award: William C. Rose Award: Celia Schiff er David Pagliarini DeLano Award for Computational Biosciences: Mildred Cohn Award in Biological Chemistry: ANNUAL MEETING Yang Zhang Carol Fierke Walter Shaw Young Investigator Award in Lipids: Jeremy Baskin NOVEMBER 2019 ASBMB TODAY 1 EDITOR’S NOTE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY It’s about time OFFICERS COUNCIL MEMBERS Gerald Hart Suzanne Barbour By Comfort Dorn President Joan Broderick Matt Gentry Toni M. Antalis Blake Hill President-elect Audrey Lamb Wei Yang James M. Ntambi Secretary Takita Felder Sumter Kelly Ten–Hagen ur concept of time is dictated, As managing editor of this mag- Joan Conaway JoAnn Trejo Treasurer at least in part, by how we azine, I have gone back to looking ASBMB TODAY EDITORIAL Ospend our days. many months into the future. We EX-OFFICIO MEMBERS ADVISORY BOARD For those who work in aca- spend a fair bit of time planning our Robert S. Haltiwanger Rajini Rao demia, the year is shaped by the feature stories and special issues, and Carla Koehler Chair Co-chairs, 2020 Annual Ana Maria Barral cycle of semesters and vacations we also need to keep in mind the Meeting Program Committee Natasha Brooks that make up a school calendar, calendar of the American Society for Kelly Chaćon Cheryl Bailey and days might include set hours Biochemistry and Molecular Biology Chair, Education and Beronda Montgomery Professional Development Bill Sullivan for teaching, study, writing and — the hub of which is the annual Committee Melissa Vaught Binks Wattenberg research. meeting. Daniel Raben When I was home taking care Here at ASBMB central, we Chair, Meetings Committee ASBMB TODAY Sonia Flores of infant children, I lived very constantly think and talk about Angela Hopp Chair, Minority Aairs Executive Editor much in the moment, and many the society’s biggest event; the next Committee [email protected] moments dragged interminably. My annual meeting is forever looming, Nicole Woiowich Comfort Dorn sleep-deprived brain seldom could even the day after the last one ends. Chair, Science Outreach and Managing Editor Communication Committee [email protected] look beyond the next feeding or We aim to include annual meeting Terri Goss Kinzy Lisa Schnabel diaper change. Toilet training and information in almost every issue of Chair, Public Aairs Graphic Designer Advisory Committee teething were processes that took ASBMB Today — because it’s that [email protected] Ed Eisenstein John Arnst months but seemed to go on for important. Chair, Membership Committee Science Writer years. Yet when my children went is month, we prole the 12 Susan Baserga [email protected] o to elementary school, it had all fascinating people who have been Chair, Women in Biochemistry Laurel Oldach and Molecular Biology Science Writter passed in a ash. named recipients of the ASBMB’s Committee [email protected] For a couple of years, I had a annual awards and will speak at the Sandra Weller Ed Marklin Chair, Publications Web Editor job as an administrator in an Epis- 2020 annual meeting in San Diego. Committee [email protected] copal church. Many of my tasks, In the past, we’ve proled award Lila M. Gierasch Allison Frick Editor-in-chief, JBC Media Specialist such as newsletters and bulletins, winners right before the meeting; A. L. Burlingame [email protected] had weekly or monthly deadlines, here, we’re trying something new. Editor, MCP Barbara Gordon but hovering overhead was the great e 2020 meeting may be ve Executive Director Nicholas O. Davidson [email protected] cycle of the liturgical year with its months away, but once you’ve read Editor-in-chief, JLR ancient rituals. e feast of Pente- about these researchers — their lives Kerry-Anne Rye Editor-in-chief, JLR cost might fall in May, but January and their science — I think you’ll wasn’t too early to start planning. want to register right away. For information on advertising, contact Pharmaceutical Media Inc. at 212-904-0374 or [email protected]. When I worked at a daily news- Depending on the pace of your paper, we had a 24-hour cycle that life right now, those ve months reset every night as soon as the next could just y by. day’s issue landed in the press room. We all liked working on long-term Comfort Dorn www.asbmb.org/asbmbtoday projects, but every day we had to ([email protected]) is the PRINT ISSN 2372-0409 managing editor of ASBMB feed the beast — and that was the Today. Follow her on Twitter @cdorn56. Articles published in ASBMB Today reect solely the authors’ views and not schedule that drove us. e advent the ocial positions of the American Society for Biochemistry and Molecular of 24-hour online news only made Biology or the institutions with which the authors are aliated. Mentions of products or services are not endorsements. the pace more frantic. 2 ASBMB TODAY NOVEMBER 2019 MEMBER UPDATE Member Update By ASBMB Today sta Gingras, Ueffing win HUPO awards transfer, DNA cleavage by anti-cancer drugs, enzymatic Anne-Claude Gingras and Marius formation of polyesters and purine biosynthesis,” accord- Ueng were among those presented with ing to the ACS. awards at the Human Proteome Orga- A member of the National Academy of Sciences nization’s annual meeting in Adelaide, since 1992, Stubbe has received numerous accolades for Australia, in September. her work, including the Humboldt Research Award, the Gingras Gingras, a principal investigator at the Welch Award and the National Medal of Science. Lunenfeld–Tanenbaum Research Institute at Mount Sinai Hospital in Toronto, a Trejo named assistant vice chancellor professor at the University of Toronto and Joann Trejo, a professor of pharma- a deputy editor of the journal Molecular cology at the University of California, San & Cellular Proteomics, was one of two Diego, School of Medicine, was appointed scientists recognized with the HUPO Dis- assistant vice chancellor for health sciences Uefng covery in Proteomics Award. e award faculty aairs in June. highlights single discoveries in the eld of proteomics Trejo Trejo, who has been on the faculty at and honored Gingras’ development of tools and methods UCSD since 2008, studies the role of G for interactomics. Gingras is known for systems biology protein–coupled receptor signaling in vascular inamma- research focused on signal transduction networks, with tion and cancer. applications in diseases from cancer to diabetes. She has served on the council of the American Society Ueng, a professor at the University of Tuebingen in for Biochemistry and Molecular Biology and the Board Germany, received the HUPO Clinical and Translational of Scientic Advisors for the National Cancer Institute. Proteomics Award. His research has demonstrated that Her work on equity and inclusion was recognized in 2016 Parkinson’s disease risk factor LRRK2 contributes to the with a UC San Diego Inclusive Excellence Award. disease by perturbing vesicular tracking in neurons. His As vice chancellor, Trejo is responsible for developing team also has studied retinal degeneration and genetic strategies for enhancing success, recruitment and reten- ciliopathies, contributing to new diagnostic approaches tion of an engaged diverse faculty and for comprehensive for these diseases. faculty development at UCSD. Stubbe honored with Priestly Medal Justement elected FASEB president JoAnne Stubbe, Novartis professor Louis Justement, a professor of mi- emerita of chemistry and biology at the crobiology at the University of Alabama at Massachusetts Institute of Technology, has Birmingham, has been elected president been named the 2020 Priestly Medal win- of the Federation of American Societies ner by the American Chemical Society. for Experimental Biology. Stubbe e award, the society’s highest honor, Justement Justement served as chair of the recognizes lifetime achievement. It is FASEB Science Policy Committee’s Train- named for Joseph Priestly, the chemist who discovered ing and Career Opportunities Subcommittee from 2008 oxygen and several other gases. to 2018 and FASEB vice president for science policy from Stubbe has spent her career investigating the mecha- 2018 to 2019. nisms of ribonucleotide reductases — enzymes that play At UAB, Justement’s research involves analyzing the an essential role in DNA replication and repair. She is molecular and functional roles of the adaptor protein being recognized for “pioneering studies of enzymatic HSH2 and the transmembrane receptor TLT2 as well as radical chemistry, long-range proton-coupled electron the virulence factors produced by Mycobacterium tuber- NOVEMBER 2019 ASBMB TODAY 3 MEMBER UPDATE culosis.
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