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2020-Commencement-Program.Pdf
One Hundred and Sixty-Second Annual Commencement JUNE 19, 2020 One Hundred and Sixty-Second Annual Commencement 11 A.M. CDT, FRIDAY, JUNE 19, 2020 2982_STUDAFF_CommencementProgram_2020_FRONT.indd 1 6/12/20 12:14 PM UNIVERSITY SEAL AND MOTTO Soon after Northwestern University was founded, its Board of Trustees adopted an official corporate seal. This seal, approved on June 26, 1856, consisted of an open book surrounded by rays of light and circled by the words North western University, Evanston, Illinois. Thirty years later Daniel Bonbright, professor of Latin and a member of Northwestern’s original faculty, redesigned the seal, Whatsoever things are true, retaining the book and light rays and adding two quotations. whatsoever things are honest, On the pages of the open book he placed a Greek quotation from the Gospel of John, chapter 1, verse 14, translating to The Word . whatsoever things are just, full of grace and truth. Circling the book are the first three whatsoever things are pure, words, in Latin, of the University motto: Quaecumque sunt vera whatsoever things are lovely, (What soever things are true). The outer border of the seal carries the name of the University and the date of its founding. This seal, whatsoever things are of good report; which remains Northwestern’s official signature, was approved by if there be any virtue, the Board of Trustees on December 5, 1890. and if there be any praise, The full text of the University motto, adopted on June 17, 1890, is think on these things. from the Epistle of Paul the Apostle to the Philippians, chapter 4, verse 8 (King James Version). -
The Nakanishi Symposium on Natural Products & Bioorganic Chemistry
The Nakanishi Symposium on Natural Products & Bioorganic Chemistry March 19, 2021 Sponsored by The Chemical Society of Japan & The American Chemical Society ー1ー Yoshito Kishi Professor Emeritus, Harvard University ■EDUCATION Bachelor of Science, Nagoya University 1961 Doctor of Philosophy (Chemistry), Nagoya University (Professors Yoshimasa Hirata and Toshio Goto) 1966 Postdoctoral Research Fellow (Chemistry), Harvard University (Professor R. B. Woodward) 1966-1968 ■ACADEMIC APPOINTMENT Instructor of Chemistry, Nagoya University 1966-1970 Associate Professor of Agricultural Chemistry, Nagoya University 1970-1974 Visiting Professor of Chemistry, Harvard University 1972-1973 Professor of Chemistry, Harvard University 1974-1982 Morris Loeb Professor of Chemistry, Harvard University 1982-2002 Morris Loeb Professor of Chemistry, Emeritus, Harvard University 2002- ー2ー ■RESEARCH TOPICS (chronological order) 1. Chemical studies of bioluminescence: The luminescent substance named luciferin is an unstable compound, making its structural determination extremely difficult. Dr. Kishi, however, determined the structures of luciferins, such as those in Cypridina, Genji fireflies, krill, dinoflagellates, and the luminous shellfish of Latia (1960s–1980s). 2. Total synthesis of complex natural products: The pufferfish toxin tetrodotoxin, the structure of which was determined in 1964, is still known as one of the most difficult natural products to synthesize due to its highly functionalized structural complexity. Dr. Kishi achieved the world’s first total synthesis of this compound in 1972. Later, he achieved total synthesis of the paralytic shellfish toxin saxitoxin, the anticancer drug mitomycin C, the fungus toxin sporidesmin, and the β-lactam antibiotics (1970s–1980s). 3. Development of acyclic stereocontrol in total synthesis of natural products: Until the early 1970s, total synthesis of polyether antibiotics was almost impossible due to the presence of numerous asymmetric centers. -
Suzanne Pfeffer
July 2010 ASBMB PreSidentiAl PriMer: Suzanne Pfeffer American Society for Biochemistry and Molecular Biology AAdjuvdjuvAAntnt IImmunothermmunotherAApypy ususIIngng KKrnrn70007000 KRN7000 (α-Galactosyl Ceramide) Avanti Number 867000 Supplier: Funakoshi Co. Ltd. Hepatic metastasis is a major clinical problem in cancer treatment. We examined antitumor ac- tivity of alpha-galactosylceramide (KRN7000) on mice with spontaneous liver metastases of re- ticulum cell sarcoma M5076 tumor cells (spontaneous metastasis model). In this model, all mice that were s.c. challenged with one million tumor cells developed a solid s.c. mass by day 7 and died of hepatic metastases. In the current study, we administered 100 microg/kg of KRN7000 to the model mice on days 7, 11, and 15. This treatment suppressed the growth of established liver metastases and resulted in the prolongation of survival time. Fluorescence-activated cell sorter analysis of phenotypes of spleen cells, hepatic lymphocytes, and regional lymph node cells around the s.c. tumor revealed that CD3+NK1.1+ (NKT) cells increased in hepatic lym- phocytes of the KRN7000-treated mice. Cytotoxic activity and IFN-gamma production of hepatic lymphocytes were augmented in comparison with those of spleen cells and regional LN cells. At the same time, interleukin (IL)-12 production of hepatic lymphocytes was markedly enhanced. Neutralization of IL-12 using a blocking monoclonal antibody diminished the prolonged survival time. These results showed that the in vivo antitumor effects of KRN7000 on spontaneous liver metastases were dependent on the endogenous IL-12 production, where NKT cells in the liver are suggested to be involved. Adjuvant immunotherapy using KRN7000 could be a promising modality for the prevention of postoperative liver metastases. -
NIH Conflict of Interest Regs Revised
OCTOBEROCTOBER 2005 www.asbmb.org Constituent Society of FASEB AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY NIH Conflict of Interest Regs Revised SEE PAGE 30 FOR NEW CLARA BENSON TRAVEL FELLOWSHIP AWARD Held in conjunction with EB2006 Custom Antibodies Your Way! Choose the protocol that is right for you! QwikScreen ™: 65 day, 2 rabbit protocol - 4 immunizations, 3 bleeds/rabbit (~100ml serum), customer supplied peptide/protein - Options: Peptide synthesis, immunograde Conjugation to carrier u ELISA u u Animal extensionsMS analysis $685 Standard: 80 day, 2 rabbit protocol - 5 immunizations, 5 bleeds/rabbit (~ 200ml ser Options: um), ELISA, customer supplied peptide/pr Peptide synthesis MS Check™ peptide sequence confirmation u HPLC purified peptide Affinity purification otein - Pinnacle: $975 u HPLC and MS analysis u Complete Affinity Purified Protocol- Animal extensions 2 rabbit pr 5 bleeds/rabbitotocol, (~ 200mlepitope serum), design, peptide PhD technical synthesis support, (up to 20mer),5 immunizations, HPLC purified to ~85%, 5+mg peptide to customer, ELISA, evaluation period, affinity purification, and morMS Check™ peptide sequence confirmationNo Hidden Charges! e… - Discounts for Multiple Protocols$1795 , Includes peptide sequencing by CID MS/MS– u Guaranteed Peptide Let our enthusiasm for scienceExpert workTechnical for SupportFidelity! P: 508.303.8222 www.21stcenturybio.com Toll-free: 877.217.8238 F: 508.303.8333 you! E: [email protected] www.asbmb.org AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY OCTOBER -
Wilfred A. Van Der Donk
WILFRED A. VAN DER DONK University of Illinois at Urbana-Champaign Department of Chemistry, 161 RAL Box 38-5 Urbana, IL 61801 Phone: (217) 244-5360; FAX: (217) 244-8533 [email protected] Date of birth April 21, 1966 US citizen since 2013 EDUCATION 1989 B.Sc & M.Sc, Leiden University, The Netherlands Thesis Advisor: Prof. Jan Reedijk Thesis Title: Model Complexes for Copper Metallo-Enzymes 1994 Ph.D., Rice University, Houston, Texas Thesis Advisor: Prof. Kevin Burgess Thesis Title: Transition Metal Catalyzed Hydroborations POSITIONS SINCE FINAL DEGREE 1994-1997 Postdoctoral Fellow, Massachusetts Institute of Technology, Cambridge, MA Advisor Prof. JoAnne Stubbe Project: Mechanistic Studies on Ribonucleotide Reductase 1997-2003 Assistant Professor, Department of Chemistry University of Illinois at Urbana-Champaign 2003-2005 Associate Professor, Department of Chemistry University of Illinois at Urbana-Champaign 2005-2008 William H. and Janet Lycan Professor of Chemistry University of Illinois at Urbana-Champaign 2008-present Richard E. Heckert Endowed Chair in Chemistry University of Illinois at Urbana-Champaign 2008-present Investigator, Howard Hughes Medical Institute 2007-present Professor, Institute for Genomic Biology University of Illinois at Urbana-Champaign FELLOWSHIPS AND AWARDS 1989 Cum Laude Masters Thesis, Leiden University 1989-1993 Robert A. Welch Predoctoral Fellowship 1991, 1994 Harry B. Weiser Scholarship for Excellence in Research (Rice University) 1994-1997 Postdoctoral Fellowship, Jane Coffin Childs Foundation for Medical Research 1997 Camille and Henry Dreyfus New Faculty Award 1998 Burroughs Wellcome New Investigator in the Pharmacological Sciences 1998 Research Innovation Award from the Research Corporation 1 1999 School of Chemical Sciences Teaching Award (U. Illinois) 1999 UIUC Research Board Beckman Award 1999 Arnold and Mabel Beckman Young Investigator Award 1999 3M Non-Tenured Faculty Award 2000 Cottrell Scholar of the Research Corporation 2001 Beckman Fellow, Center for Advanced Study, University of Illinois 2001 Alfred P. -
Giant Gene Thieves Have You Renewed Your Membership for 2020?
Vol. 18 / No. 10 / November 2019 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Giant gene thieves Have you renewed your membership for 2020? Together, we’ll continue to advocate for science, connect researchers around the world and build a bright future for biochemists and molecular biologists everywhere. Learn more at www.asbmb.org/membership CONTENTS NEWS FEATURES PERSPECTIVES 2 24 50 GIANT GENE THIEVES SERVICE BEYOND SCIENCE EDITOR’S NOTE ese viruses are changing what we know Weaving social innovation and scienti c It’s about time about structural and evolutionary biology methods for a bright future 3 32 MEMBER UPDATE MEET SEAN DAVIDSON 7 e JLR associate editor rethinks cholesterol NEW MEMBERS 9 24 YEAR OF (BIO)CHEMICAL ELEMENTS For November, it’s that smell of sulfur 10 NEWS Bacterial invasion may explain recurrent urinary tract infections 11 13 JOURNAL NEWS 11 Snug as a bug in the mud 50 13 Researchers clock DNA’s recovery time 14 Lack of sleep a ects fat metabolism 15 is protein makes antibody drugs work 16 From the journals 22 LIPID NEWS Phospholipids and innate immunity 32 2020 Award Winners … page 37 Ruth Kirschstein Diversity in Science Award: ASBMB Award for Exemplary Contributions to Lizabeth Allison Education: Paul Black Herbert Tabor Research Award: Kevin Campbell Bert and Natalie Vallee Award: Edward Dennis ASBMB–Merck Award: Manajit Hayer–Hartl Alice and C. C. Wang Award in Molecular Parasitology: Patricia Johnson Avanti Award in Lipids: Jean Schaff er Earl and Thressa Stadtman Young Scholar Award: William C. Rose Award: Celia Schiff er David Pagliarini DeLano Award for Computational Biosciences: Mildred Cohn Award in Biological Chemistry: ANNUAL MEETING Yang Zhang Carol Fierke Walter Shaw Young Investigator Award in Lipids: Jeremy Baskin NOVEMBER 2019 ASBMB TODAY 1 EDITOR’S NOTE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY It’s about time OFFICERS COUNCIL MEMBERS Gerald Hart Suzanne Barbour By Comfort Dorn President Joan Broderick Matt Gentry Toni M. -
Chemical Compositions the Magazine of the Department of Chemistry and Biochemistry the University of Texas at Austin OH O O O O O O O O H N H O N 1
Fall l 2008 CC Chemical Compositions The Magazine of The Department of Chemistry and Biochemistry The University of Texas at Austin O OH O O O O O O O H N H O N 1. nBuLi O OTBS O N ∆ Br Br MeO2C N 2. R"X R R" O OH Pd Enolate N 2 CO2H S S N Me R' R" N N H Me Arylation N R R' R' Lewis Acid Mediated Me Me R N S S N Me O Coupling H O O OH 1 3 4 OH NH2 OAc O OH O O OH O H H H O Allylic TMS i. 4Å MS, CH3CN MeO2C (-)-gliotoxin MeO2C MeO2C ii. TFA, -45 °C to rt O O O Alkylation O + O OMe HO N N N OMe N Me Me Me H N NH iii. NaCN aq., CH2Cl2 emestrin 5 6 7 N 1. nBuLi N ∆ 2 N 2. R"X OMe CN 1-pot R R" 89% (88:12) NCbz O R R' R' Cbz R R" e.g. N O BnO N R' NH2 O R1 H HO H Cl R2 1 2 R O + R N N O Ts OH H Br M R Ar R N N Ar O Me OH Cl Me OH Me H Br N Me N N H NH Me p-toluenesulfonic acid H Me O Me HO o O H 0 C O Me (-)-epimyrtine (±)-tashiromine CN Me N 30 min Ts (-)-Caryophyllene Oxide 30% Br (HO) OP O ∆G ∆H T∆S 2 (HO)2OP O Compounda -1 Ka (M ) (kcal/mol) (kcal/mol) (kcal/mol) 1 [1.0 ± 0.1] x 106 -8.2 ± 0.1 -7.0 ± 0.1 1.2 ± 0.03 2 [4.4 ± 0.4] x 105 -7.7 ± 0.1 -5.3 ± 0.1 2.4 ± 0.06 O Acyclic O 7 O Control O 3 [8.5 ± 0.3] x 105 -8.1 ± 0.1 -6.2 ± 0.02 1.9 ± 0.02 N N Acyclic 2 H H 5 Control HN O HN (3) ([5.6 ± 0.2] x 10 ) (-7.9 ± 0.1) (-4.9 ± 0.02) (3.0 ± 0.02) HN R R R R Macro- 4 [9.9 ± 2.9] x 106 -9.5 ± 0.2 -4.8 ± 0.1 4.7 ± 0.2 HN O cyclization O HN O N N N N NH HN (4) ([6.5 ± 0.9] x 106) (-9.3 ± 0.1) (-6.4 ± 0.04) (2.9 ± 0.1) Macro- cyclization H O N N O a Results in parentheses refer to corresponding acyclic controls. -
Protein Kinase Activation
SEE INSIDE FOR 2008 ANNUAL MEETING SESSION OVERVIEWS July 2007 Protein Kinase Activation American Society for Biochemistry and Molecular Biology POSTDOCTORAL FELLOWSHIP Department of Dermatology, OHSU, Portland, Oregon Training Program in Molecular Basis of Skin Pathobiology Promoting Understanding Position for recent PhD, MD/PhD or MD (US citizen or Permanent Resident) in NIH-funded program for training highly of the Molecular Nature qualifi ed candidates for academic careers in basic & translational research in skin diseases, including cancer & psoriasis. OHSU Dermatology has a strong history of clinical & scientifi c of Life Processes research & a 40-year record in training dermatology residents including physician scientists & postdoctoral scientists on the path to independence. Features of this training program are a core of Dermatology faculty & a multidisciplinary network of scientists with international recognition in areas highly relevant to epithelial cell fate, development & diseases. The training program includes seminars in mentors’ departments, Dermatology Research Division meetings & symposia, research forums tailored to postdoctoral students, & national/international meetings in cutaneous biology. Successful candidates desiring an academic career in basic or translational research in cancer The Society’s purpose is to or investigative dermatology using surface epithelial models can advance the science of bio- expect to receive training toward independence in research with chemistry & molecular biology a strong clinical translational -
CHEMISTRY NEWS UNIVERSITY of OREGON COLLEGE of ARTS and SCIENCES DEPARTMENT of CHEMISTRY 1996 from the DEPARTMENT HEAD the Past Year Was an Exhilarat- Didates
CHEMISTRY NEWS UNIVERSITY OF OREGON COLLEGE OF ARTS AND SCIENCES DEPARTMENT OF CHEMISTRY 1996 FROM THE DEPARTMENT HEAD The past year was an exhilarat- didates. We did something un- ing one for the Department of heard offor Oregon anywaywe Chemistry. Among many exciting requested permission to hire both things that happened, we hired candidates. To our mild surprise, two new faculty members, our the deans office and the Graduate Achievement Endowment Fund School agreed this was an opportu- continues to grow, we honored nity we should not miss. We hired three distinguished alumni with both Andy Marcus and Mark achievement awards, members of Lonergan. Im sure it is obvious our faculty were recognized with that the administration wouldnt national and local awards, and we do this for just any department. It graduated thirty-eight enthusiastic is a sign of our departments undergraduate and graduate stu- strength and quality that we were dents. Let me briefly recount these permitted to hire two new faculty events and achievements. members. Last fall we ran a search for a One of the reasons our depart- physical chemist to replace Warner ment remains optimistic about the Peticolas, who retired. We inter- future is that we have generous viewed four candidates and found alumni who contribute to our © JACK LIU ourselves having to decide be- growing Achievement Endowment tween two absolutely superb can- continued on page 2 Chemistry Commencement Gets Personal Remember when the only and friends. In a new twist this graduation event was a large gath- year, students wrote a humorous ering on a football field? Times script, Our Seniors Top Ten List have changed. -
Hatzios Thesis Formatted
Investigations of Metabolic Pathways in Mycobacterium tuberculosis by Stavroula K Hatzios A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Chemistry in the Graduate Division of the University of California, Berkeley Committee in charge: Professor Carolyn R. Bertozzi, Chair Professor Matthew B. Francis Professor Tom Alber Fall 2010 Investigations of Metabolic Pathways in Mycobacterium tuberculosis © 2010 By Stavroula K Hatzios Abstract Investigations of Metabolic Pathways in Mycobacterium tuberculosis by Stavroula K Hatzios Doctor of Philosophy in Chemistry University of California, Berkeley Professor Carolyn R. Bertozzi, Chair Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis in humans, infects roughly two billion people worldwide. However, less than one percent of infected individuals are symptomatic. Most have a latent infection characterized by dormant, non- replicating bacteria that persist within a mass of immune cells in the lung called the granuloma. The granuloma provides a protective barrier between infected cells and surrounding tissue. When host immunity is compromised, the granuloma can deteriorate and reactivate the disease. In order to mount a latent infection, Mtb must survive in alveolar macrophages, the host’s primary line of defense against this intracellular pathogen. By evading typical bactericidal processes, Mtb is able to replicate and stimulate granuloma formation. The mechanisms by which Mtb persists in macrophages are ill defined; thus, elucidating the factors responsible for this hallmark of Mtb pathogenesis is an important area of research. This thesis explores three discrete metabolic pathways in Mtb that are likely to mediate its interactions with host immune cells. The first three chapters examine the sulfate assimilation pathway of Mtb and its regulation by the phosphatase CysQ. -
Fall 2007 Office of the Secretary-Treasurer Department Of
Fall 2007 Office of the Secretary-Treasurer Department of Chemistry University of Pennsylvania Philadelphia, PA 19104-6323 Phone: 215-573-1246 Fax: 215-573-2112 e-mail: [email protected] Executive Committee Members, 2007-08 Members at Large Councilors Alternate Councilors Barry Snider, Chair Kevin Burgess Michael P. Doyle Kay M. Brummond Kathy Parker, Past-Chair Franklin A. Davis Scott Rynchnovsky Mark D. Distefano Robert Volkmann, Chair-Elect Kelly George Barry B. Snider Paul L.Feldman Gary Molander, Secretary/Treasurer Molly E. Hoke Christopher J. Welch Robert J. McMahon William Greenlee, Program Chair Marisa C. Kozlowski Scott McN. Sieburth, Program Chair Elect Cynthia A. Maryanoff P. Andrew Evans, NOS Exec. Officer 2007 Peter G.M. Wuts Mukund Sibi, NOS Exec. Officer 2009 Current information about the Division is always available on the web at http://organicdivision.org Webmaster: Brian Myers You are invited to attend National meetings of the ACS and present contributed papers (oral or poster). Instructions for submission of papers are near the end of this letter in the section entitled "Information for Submission of a Paper or Poster." Please read them carefully. Submissions should arrive by the indicated deadline for each meeting, which is published in the membership newsletter and C&E News (January and July) and posted on the ACS Website: http://www.chemcenter.org/. Members also are encouraged to submit brief proposals to the National Program Chair for contributed symposia at future National ACS meetings. Contact: William Greenlee, Vice President, CNS&CV Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, Tel: (908) 740-2220, Fax: (908) 740-7164, Email: [email protected] Edward Leete Award Winner Jeremiah Johnson, Columbia University Schering Plough Fellow We are pleased to announce that the winner of the 2007 Nicholas J. -
1968 Commencement Program
UNIVERSITY of PENNSYLVANIA - Two Hundred and Twelfth Commencement for the Conferring of Degrees PHILADELPHIA CIVIC CENTER Monday, May 20, 1968 10:00 A.M. jJ STAGE (1, ......II ,........I " Official Guests Medicine College for Women Graduate Medicine Wharton Law College Nursing Graduate Allied Fine Arts Medical Professions Dental Medicine Veterinary Medicine Wharton Graduate Graduate Arts& Sciences Civil& Mechanical Engineering Chemical Graduate Engineering Education Electrical Engineering Social Work Metallurgy Annenberg Guests will find this diagram helpful in locating the opposite page under Degrees in Course. Reference approximate seating of the degree candidates. The to the paragraph on page seven describing the seating and the order of march in the student pro colors of the candidates' hoods according to their cession correspond closely to the order by school fields of study may further assist guests in placing in which the candidates for degrees are presented. the locations of the various schools. This sequence is shown in the Contents on the Contents Page Seating Diagram of the Graduating Students .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. 2 The Commencement Ceremony . 4 Background of the Ceremonies . .. .. .. 6 Degrees in Course . .. .. .. 8 The College of Arts and Sciences . 8 The Engineering Schools . .. .. .. 14 The Towne School of Civil and Mechanical Engineering ... ........ ......... 14 The School of Chemical Engineering . .. .. .. 15 The Moore School of Electrical Engineering . .. 16 The School of Metallurgy and Materials Science . .. .. 18 The Wharton School of Finance and Commerce . 19 The College of Liberal Arts for Women ....... .. ... ...... .. .. .... ............ ..... .. ......... 26 The School of Nursing ... ........................... .... ................ ... ................... ........ 31 The School of Allied Medical Professions . .. .. 3 3 The Graduate School of Arts and Sciences . .. .. .. 34 The School of Medicine .