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From DNA Nanotechnology to Material Systems Engineering
PROGRESS REPORT DNA Nanotechnology www.advmat.de From DNA Nanotechnology to Material Systems Engineering Yong Hu and Christof M. Niemeyer* supramolecular networks. These devel- In the past 35 years, DNA nanotechnology has grown to a highly innovative opments have given rise to numerous and vibrant field of research at the interface of chemistry, materials science, so-called “DNA tiles” that can be used as biotechnology, and nanotechnology. Herein, a short summary of the state building blocks for the assembly through of research in various subdisciplines of DNA nanotechnology, ranging from sticky-end cohesion into discrete “finite” objects or periodic “infinite” 2D and 3D pure “structural DNA nanotechnology” over protein–DNA assemblies, periodic lattices.[4] However, since the nanoparticle-based DNA materials, and DNA polymers to DNA surface production of finite DNA nanostructures technology is given. The survey shows that these subdisciplines are growing from DNA tiles remained complicated,[5] ever closer together and suggests that this integration is essential in order to the development of the “scaffolded DNA initiate the next phase of development. With the increasing implementation origami” technique by Rothemund[6] is of machine-based approaches in microfluidics, robotics, and data-driven to be seen as an important milestone. Indeed, this method enabled the break- science, DNA-material systems will emerge that could be suitable for through of DNA nanotechology for the applications in sensor technology, photonics, as interfaces between technical fabrication of finite, programmable, and systems and living organisms, or for biomimetic fabrication processes. addressable nanostructures, thereby initi- ating a second wave of innovation in the field.[7] As discussed in Section 2, this set 1. -
Biochemistrystanford00kornrich.Pdf
University of California Berkeley Regional Oral History Office University of California The Bancroft Library Berkeley, California Program in the History of the Biosciences and Biotechnology Arthur Kornberg, M.D. BIOCHEMISTRY AT STANFORD, BIOTECHNOLOGY AT DNAX With an Introduction by Joshua Lederberg Interviews Conducted by Sally Smith Hughes, Ph.D. in 1997 Copyright 1998 by The Regents of the University of California Since 1954 the Regional Oral History Office has been interviewing leading participants in or well-placed witnesses to major events in the development of Northern California, the West, and the Nation. Oral history is a method of collecting historical information through tape-recorded interviews between a narrator with firsthand knowledge of historically significant events and a well- informed interviewer, with the goal of preserving substantive additions to the historical record. The tape recording is transcribed, lightly edited for continuity and clarity, and reviewed by the interviewee. The corrected manuscript is indexed, bound with photographs and illustrative materials, and placed in The Bancroft Library at the University of California, Berkeley, and in other research collections for scholarly use. Because it is primary material, oral history is not intended to present the final, verified, or complete narrative of events. It is a spoken account, offered by the interviewee in response to questioning, and as such it is reflective, partisan, deeply involved, and irreplaceable. ************************************ All uses of this manuscript are covered by a legal agreement between The Regents of the University of California and Arthur Kornberg, M.D., dated June 18, 1997. The manuscript is thereby made available for research purposes. All literary rights in the manuscript, including the right to publish, are reserved to The Bancroft Library of the University of California, Berkeley. -
2012 Annual Report
Memorial Sloan-Kettering Cancer Center 2012 ANNUAL REPORT A SHARED VISION A SINGULAR MISSION Nurse practitioner Naomi Cazeau, of the Adult Bone Marrow Transplant Service. PING CHI PHYSICIAN-SCIENTIST 10 STEPHEN SOLOMON ALEXANDER RUDENSKY INTERVENTIONAL IMMUNOLOGIST RADIOLOGIST 16 12 VIVIANE TABAR The clinicians and scientists of NEUROSURGEON Memorial Sloan-Kettering share a vision and 18 a singular mission — to conquer cancer. STEPHEN LONG STRUCTURAL BIOLOGIST They are experts united against a 20 SIMON POWELL complex disease. Each type of cancer R ADIATION ONCOLOGIST 24 ETHEL LAW is different, each tumor is unique. Set free NURSE PRACTITIONER in surroundings that invite the sharing of 26 ideas and resources, they attack the CHRISTINA LESLIE complexity of cancer from every angle COMPUTATIONAL BIOLOGIST and every discipline. 34 SCOTT ARMSTRONG PEDIATRIC ONCOLOGIST 30 TO JORGE REIS-FILHO EXPERIMENTAL PATHOLOGIST CONQUER 38 CANCER 04 Letter from the Chairman and the President A complete version of this report — 42 Statistical Profile which includes lists of our donors, 44 Financial Summary doctors, and scientists — 46 Boards of Overseers and Managers is available on our website at 49 The Campaign for Memorial Sloan-Kettering www.mskcc.org/annualreport. 4 5 Letter from the Chairman In 2012 the leadership of Memorial Sloan-Kettering endorsed Douglas A. Warner III These programmatic investments require leadership and and the President a $2.2 billion investment in a clinical expansion that will set vision. Our new Physician-in-Chief, José Baselga, joined the stage for a changing care paradigm into the next decade us on January 1, 2013. An internationally recognized and beyond. -
DNA Nanotechnology Meets Nanophotonics
DNA nanotechnology meets nanophotonics Na Liu 2nd Physics Institute, University of Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany Max Planck Institute for Solid State Research, Heisenbergstrasse 1, 70569 Stuttgart, Germany Email: [email protected] Key words: DNA nanotechnology, nanophotonics, DNA origami, light matter interactions Call-out sentence: It will be very constructive, if more research funds become available to support young researchers with bold ideas and meanwhile allow for failures and contingent outcomes. The first time I heard the two terms ‘DNA nanotechnology’ and ‘nanophotonics’ mentioned together was from Paul Alivisatos, who delivered the Max Planck Lecture in Stuttgart, Germany, on a hot summer day in 2008. In his lecture, Paul showed how a plasmon ruler containing two metallic nanoparticles linked by a DNA strand could be used to monitor nanoscale distance changes and even the kinetics of single DNA hybridization events in real time, readily correlating nanoscale motion with optical feedback.1 Until this day, I still vividly remember my astonishment by the power and beauty of these two nanosciences, when rigorously combined together. In the past decades, DNA has been intensely studied and exploited in different research areas of nanoscience and nanotechnology. At first glance, DNA-based nanophotonics seems to deviate quite far from the original goal of Nadrian Seeman, the founder of DNA nanotechnology, who hoped to organize biological entities using DNA in high-resolution crystals. As a matter of fact, DNA-based nanophotonics does closely follow his central spirit. That is, apart from being a genetic material for inheritance, DNA is also an ideal material for building molecular devices. -
NIH Conflict of Interest Regs Revised
OCTOBEROCTOBER 2005 www.asbmb.org Constituent Society of FASEB AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY NIH Conflict of Interest Regs Revised SEE PAGE 30 FOR NEW CLARA BENSON TRAVEL FELLOWSHIP AWARD Held in conjunction with EB2006 Custom Antibodies Your Way! Choose the protocol that is right for you! QwikScreen ™: 65 day, 2 rabbit protocol - 4 immunizations, 3 bleeds/rabbit (~100ml serum), customer supplied peptide/protein - Options: Peptide synthesis, immunograde Conjugation to carrier u ELISA u u Animal extensionsMS analysis $685 Standard: 80 day, 2 rabbit protocol - 5 immunizations, 5 bleeds/rabbit (~ 200ml ser Options: um), ELISA, customer supplied peptide/pr Peptide synthesis MS Check™ peptide sequence confirmation u HPLC purified peptide Affinity purification otein - Pinnacle: $975 u HPLC and MS analysis u Complete Affinity Purified Protocol- Animal extensions 2 rabbit pr 5 bleeds/rabbitotocol, (~ 200mlepitope serum), design, peptide PhD technical synthesis support, (up to 20mer),5 immunizations, HPLC purified to ~85%, 5+mg peptide to customer, ELISA, evaluation period, affinity purification, and morMS Check™ peptide sequence confirmationNo Hidden Charges! e… - Discounts for Multiple Protocols$1795 , Includes peptide sequencing by CID MS/MS– u Guaranteed Peptide Let our enthusiasm for scienceExpert workTechnical for SupportFidelity! P: 508.303.8222 www.21stcenturybio.com Toll-free: 877.217.8238 F: 508.303.8333 you! E: [email protected] www.asbmb.org AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY OCTOBER -
Pnas11052ackreviewers 5098..5136
Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H. -
DNA 7 - Seveth International Meeting on DNA Based Computers - Instruction for Authors
DNA 7 - Seveth International Meeting on DNA Based Computers - Instruction for Authors DNA7 Seventh International Meeting on DNA Based Computers June 10-13, 2001 Download this Document as .pdf | .doc | .rtf Introduction Biomolecular computing has emerged as a an interdisciplinary field that draws together molecular biology, chemistry, computer science and mathematics. Our knowledge of DNA nanotechnology and biomolecular computing increases exponentially with every passing year. The annual international meeting has been a forum where scientists with different backgrounds, yet sharing a common interest in biomolecular computing, meet and present their latest results. Continuing with this tradition, the 7th International Meeting on DNA Based Computers will focus on the current theoretical and experimental results with the greatest impact. Papers and poster presentations are sought in all areas that relate to computing with biomolecules including (but not limited to): algorithms and applications, models of biomolecular computation (using DNA and/or other molecules), analysis of laboratory techniques and theoretical models, error correction, sequence design, simulation software, DNA chemistry, DNA motifs, DNA devices, and computational processes in vivo. We particularly encourage papers and posters reporting experimental results. Instruction for Authors ● Each paper should include one address and e-mail address for all correspondence related to the submission. ● Each paper should contain an abstract stating the main results and their importance. ● We encourage document preparation in LaTex, but PostScript, pdf and MSWord files will also be accepted. For the final version of the document please follow the guidelines for the Springer-Verlag LNCS series at: http://www.springer.de/comp/lncs/authors.html ● The preferred format for submission is a .PDF, .PS or .RTF file or e-mailed to the chair of the program committee at: [email protected]. -
Single Molecule Based Nanoelectronics
Deanship of Graduate Studies AL-Quds University Single Molecule Based Nanoelectronics Ali Mohammed Kayed Atawneh M. Sc. Thesis Jerusalem-Palestine 1426 / 2006 Chapter one _______________________________________________________________ Introduction 1.1. Introduction Nanoscience is the study of phenomena and manipulating of materials at atomic, molecular and macromolecular scales, where nano-sciences are lead to a better understanding of properties of materials at the atomic level, or resulting from the reduction of dimensions down to the nanometer range. And many technologies are concerned with producing new industrial materials on nano-meter scale – one of these technologies is nanotechnology- but one of the problems facing nanotechnology actually physics, so physics is different on the nanometer scale, the properties of materials can behave differently and have new characteristics. Nanotechnologies are anew expression of a fundamental concept concerned with the development of tools for molecular electronics, that can be used first for measuring properties, then for assembling atoms and molecules to create new materials having superior properties useful in the fabrication of nano-electronic devices. So, nanotechnology includes both molecular electronics and nanoscale devices, where it is research's are aimed at building very small machines and electronics and constructing materials molecule-by-molecule and aggregates that can perform the basic functions of larger electronic components and assemble them into atomically precise molecular electronic devices (Joachim, Gimzewski, Aviram, 2000). Raw materials of nanotechnology include inorganic matter like metals and semiconductors, molecules like polymers and carbon nanotubes, and biological molecules like DNA and proteins. Devices that have dimension on a nanometer scale are called nanoelectronic devices; the use of nanoelectronic devices is interested for several reasons. -
Giant Gene Thieves Have You Renewed Your Membership for 2020?
Vol. 18 / No. 10 / November 2019 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Giant gene thieves Have you renewed your membership for 2020? Together, we’ll continue to advocate for science, connect researchers around the world and build a bright future for biochemists and molecular biologists everywhere. Learn more at www.asbmb.org/membership CONTENTS NEWS FEATURES PERSPECTIVES 2 24 50 GIANT GENE THIEVES SERVICE BEYOND SCIENCE EDITOR’S NOTE ese viruses are changing what we know Weaving social innovation and scienti c It’s about time about structural and evolutionary biology methods for a bright future 3 32 MEMBER UPDATE MEET SEAN DAVIDSON 7 e JLR associate editor rethinks cholesterol NEW MEMBERS 9 24 YEAR OF (BIO)CHEMICAL ELEMENTS For November, it’s that smell of sulfur 10 NEWS Bacterial invasion may explain recurrent urinary tract infections 11 13 JOURNAL NEWS 11 Snug as a bug in the mud 50 13 Researchers clock DNA’s recovery time 14 Lack of sleep a ects fat metabolism 15 is protein makes antibody drugs work 16 From the journals 22 LIPID NEWS Phospholipids and innate immunity 32 2020 Award Winners … page 37 Ruth Kirschstein Diversity in Science Award: ASBMB Award for Exemplary Contributions to Lizabeth Allison Education: Paul Black Herbert Tabor Research Award: Kevin Campbell Bert and Natalie Vallee Award: Edward Dennis ASBMB–Merck Award: Manajit Hayer–Hartl Alice and C. C. Wang Award in Molecular Parasitology: Patricia Johnson Avanti Award in Lipids: Jean Schaff er Earl and Thressa Stadtman Young Scholar Award: William C. Rose Award: Celia Schiff er David Pagliarini DeLano Award for Computational Biosciences: Mildred Cohn Award in Biological Chemistry: ANNUAL MEETING Yang Zhang Carol Fierke Walter Shaw Young Investigator Award in Lipids: Jeremy Baskin NOVEMBER 2019 ASBMB TODAY 1 EDITOR’S NOTE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY It’s about time OFFICERS COUNCIL MEMBERS Gerald Hart Suzanne Barbour By Comfort Dorn President Joan Broderick Matt Gentry Toni M. -
An Overview of the State of Chinese Nanoscience and Technology
SMALL SCIENCE IN BIG CHINA An overview of the state of Chinese nanoscience and technology. Conducted in collaboration between Springer Nature, the National Center for Nanoscience and Technology, China, and the National Science Library of the Chinese Academy of Sciences. Ed Gerstner The National Center for Nanoscience and Springer Nature, China Minghua Liu Technology, China National Center for The National Center for Nanoscience and Technology, China (NCNST) was established in December 2003 by the Nanoscience and Chinese Academy of Science (CAS) and the Ministry of Education as an institution dedicated to fundamental and Technology, China applied research in the field of nanoscience and technology, especially those with important potential applications. Xiangyang Huang NCNST is operated under the supervision of the Governing Board and aims to become a world-class research National Science Library, centre, as well as public technological platform and young talents training centre in the field, and to act as an Chinese Academy of important bridge for international academic exchange and collaboration. Sciences The NCNST currently has three CAS Key Laboratories: the CAS Key Laboratory for Biological Effects of Yingying Zhou Nanomaterials & Nanosafety, the CAS Key Laboratory for Standardization & Measurement for Nanotechnology, Nature Research, Springer and the CAS Key Laboratory for Nanosystem and Hierarchical Fabrication. Besides, there is a division of Nature, China nanotechnology development, which is responsible for managing the opening and sharing of up-to-date instruments and equipment on the platform. The NCNST has also co-founded 19 collaborative laboratories with Zhiyong Tang Tsinghua University, Peking University, and CAS. National Center for The NCNST has doctoral and postdoctoral education programs in condensed matter physics, physical Nanoscience and chemistry, materials science, and nanoscience and technology. -
The Member Magazine of the American Society for Biochemistry and Molecular Biology
Vol. 14 / No. 3 / March 2015 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY CONTENTS NEWS FEATURES PERSPECTIVES 2 14 50 PRESIDENT’S MESSAGE GIVING PARASITES THEIR DUE COORDINATES Conscience of commitment Chasing the North American Dream 20 4 STEAM 52 NEWS FROM THE HILL When our DNA is fair game CAREER INSIGHTS Gene-editing summit A Q&A with Clemencia Rojas 22 5 ANNUAL MEETING POINTERS 14 MEMBER UPDATE 32 8 ANNUAL AWARDS RETROSPECTIVE Marion Sewer (1972 – 2016) 22 10 JOURNAL NEWS 10 Turning on the thyroid 20 11 Using microRNAs to target cancer cells 12 A mouse model for Hajdu–Cheney syndrome 13 One gene, two proteins, one complex 8 32 50 2016 10 Annual Aards MARCH 2016 ASBMB TODAY 1 PRESIDENT’S MESSAGE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Conscience OFFICERS COUNCIL MEMBERS Steven McKnight Squire J. Booker of commitment President Karen G. Fleming Gregory Gatto Jr. Natalie Ahn Rachel Green By Steven McKnight President-Elect Susan Marqusee Karen Allen Jared Rutter Secretary Brenda Schulman Michael Summers very four years, my institution work with the American Society for Toni Antalis Treasurer requires that I take a course Biochemistry and Molecular Biol- ASBMB TODAY EDITORIAL ADVISORY BOARD E and exam regarding conicts ogy, I can help organize and attend EX-OFFICIO MEMBERS Charles Brenner of interest. Past courses have focused meetings, I can give lectures at other Squire Booker Chair primarily on nancial conicts of institutions, I can help found biotech- Wei Yang Michael Bradley Co-chairs, 2016 Annual Floyd “Ski” Chilton interest, but the course and test I took nology companies, and on and on — Meeting Program Cristy Gelling this past month had a new category so long as the activities have legitimate Committee Peter J. -
Protein Kinase Activation
SEE INSIDE FOR 2008 ANNUAL MEETING SESSION OVERVIEWS July 2007 Protein Kinase Activation American Society for Biochemistry and Molecular Biology POSTDOCTORAL FELLOWSHIP Department of Dermatology, OHSU, Portland, Oregon Training Program in Molecular Basis of Skin Pathobiology Promoting Understanding Position for recent PhD, MD/PhD or MD (US citizen or Permanent Resident) in NIH-funded program for training highly of the Molecular Nature qualifi ed candidates for academic careers in basic & translational research in skin diseases, including cancer & psoriasis. OHSU Dermatology has a strong history of clinical & scientifi c of Life Processes research & a 40-year record in training dermatology residents including physician scientists & postdoctoral scientists on the path to independence. Features of this training program are a core of Dermatology faculty & a multidisciplinary network of scientists with international recognition in areas highly relevant to epithelial cell fate, development & diseases. The training program includes seminars in mentors’ departments, Dermatology Research Division meetings & symposia, research forums tailored to postdoctoral students, & national/international meetings in cutaneous biology. Successful candidates desiring an academic career in basic or translational research in cancer The Society’s purpose is to or investigative dermatology using surface epithelial models can advance the science of bio- expect to receive training toward independence in research with chemistry & molecular biology a strong clinical translational