Differentiation of the Secondary Elastic Cartilage in the External Ear of the Rat
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The Science of Aging Skin Leslie Baumann, MD; Susan Weinkle, MD
REVIEW Improving Elasticity: The Science of Aging Skin Leslie Baumann, MD; Susan Weinkle, MD Although collagen changes from both chronologic aging and photoaging have been well stud- ied, there is a dearth of research into the elastin component of the dermis. No products have been approved by the US Food and Drug Administration for either replacing elastin or stimulating its syn- thesis. Recently, a zinc complex was shown to increase dermal elastin staining, hypodermal fat, and epidermal thickness in animal studies. Histologic studies of the same zinc complex in humans have revealed increased deposition of functional elastin fibers following 10 days of use. In the clinical trials reported here, there was an increase in functional elastin, as well as improvements in fine lines and wrinkles. COSNo adverse events were noted. DERM ollagen and elastin are the fibers that make collagen bundles and endow the skin with rebounding up the dermal matrix. Cosmetic dermatol- properties. Tropoelastin molecules, which are precur- ogists have long used topical medications, sors to elastin, bind covalently with cross-links to form fillers, and light-based and laser-based elastin. Elastin fibers are assembled on bundles of micro- therapies to improve the loss of collagen fibrils composed of fibrillin. The latter forms a template Cthat occurs in aging skin. However, until recently, no fill- on which elastin is deposited.1 Most elastin production ers orDo topical agents have been availableNot to treat the loss is restricted Copy to a narrow window of development. Elas- of function of elastin, which is also an important feature togenesis increases dramatically during fetal life, peaks of dermal photoaging. -
Applications of Chondrocyte-Based Cartilage Engineering: an Overview
Hindawi Publishing Corporation BioMed Research International Volume 2016, Article ID 1879837, 17 pages http://dx.doi.org/10.1155/2016/1879837 Review Article Applications of Chondrocyte-Based Cartilage Engineering: An Overview Abdul-Rehman Phull,1 Seong-Hui Eo,1 Qamar Abbas,1 Madiha Ahmed,2 and Song Ja Kim1 1 Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongjudaehakro 56, Gongju 32588, Republic of Korea 2Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan Correspondence should be addressed to Song Ja Kim; [email protected] Received 14 May 2016; Revised 24 June 2016; Accepted 26 June 2016 Academic Editor: Magali Cucchiarini Copyright © 2016 Abdul-Rehman Phull et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and transcriptional factors regulate the mesenchymal stem cells (MSCs) differentiation to chondrocytes. The number of chondrocytes and dedifferentiation are the key limitations in subsequent clinical application of the chondrocytes. Different culture methods are being developed to overcome such issues. Using tissue engineering and cell based approaches, chondrocytes offer prominent therapeutic option specifically in orthopedics for cartilage repair and to treat ailments such as tracheal defects, facial reconstruction, and urinary incontinence. Matrix-assisted autologous chondrocyte transplantation/implantation is an improved version of traditional autologous chondrocyte transplantation (ACT) method. An increasing number of studies show the clinical significance of this technique for the chondral lesions treatment. -
Flavio Akira Sakae Distribuição Das Fibras Colágenas E Do Sistema De
Flavio Akira Sakae Distribuição das fibras colágenas e do sistema de fibras elásticas na camada superficial da lâmina própria da prega vocal com edema de Reinke Tese apresentada à Faculdade de Medicina da Universidade de São Paulo para obtenção do título de Doutor em Ciências Área de concentração: Otorrinolaringologia Orientador: Prof. Dr. Domingos Hiroshi Tsuji São Paulo 2008 Dados Internacionais de Catalogação na Publicação (CIP) Preparada pela Biblioteca da Faculdade de Medicina da Universidade de São Paulo Óreprodução autorizada pelo autor Sakae, Flavio Akira Distribuição das fibras colágenas e do sistema de fibras elásticas na camada superficial da lâmina própria da prega vocal com edema de Reinke / Flavio Akira Sakae. -- São Paulo, 2008. Tese(doutorado)--Faculdade de Medicina da Universidade de São Paulo. Departamento de Oftalmologia e Otorrinolaringologia. Área de concentração: Otorrinolaringologia. Orientador: Domingos Hiroshi Tsuji. Descritores: 1.Edema laríngeo 2.Colágeno 3.Tecido elástico 4.Membrana mucosa 5.Cordas vocais USP/FM/SBD-146/08 "O único homem que está isento de erros, é aquele que não arrisca acertar." Albert Einstein Dedicatória Aos meus queridos pais, Masao e Junko, por tudo que fazem por mim, pelo apoio incondicional e amor eterno. São os meus ídolos. A minha esposa, Renata, amor da minha vida, pela alegria de viver, companheirismo e incentivo constante. A minha irmã, Cristiane, por ter contribuído em todos os passos de minha vida. Agradecimentos Ao meu orientador, Prof. Dr. Domingos Hiroshi Tsuji pela oportunidade e apoio na concretização deste sonho. Sua amizade e franqueza foram essenciais na elaboração deste trabalho. É o grande mestre. Ao Prof. Dr. -
Bone & Cartilage
Compiled and circulated by Mr. Suman Kalyan Khanra, SACT, Dept. of Physiology, Narajole Raj college BONE & CARTILAGE (Structure, Function, Classification of BONE & CARTILAGE) BY Suman Kalyan Khanra SACT Department of Physiology NARAJOLE RAJ COLLEGE Narajole; Paschim Medinipur 1 | P a g e ZOOLOGY: SEM-III, Paper-C6T: Animal Physiology, Unit-2: Bone & Cartilage Compiled and circulated by Mr. Suman Kalyan Khanra, SACT, Dept. of Physiology, Narajole Raj college BONE Definition: A bone is a somatic structure that is comprised of calcified connective tissue. Ground substance and collagen fibers create a matrix that contains osteocytes. These cells are the most common cell found in mature bone and responsible for maintaining bone growth and density. Within the bone matrix both calcium and phosphate are abundantly stored, strengthening and densifying the structure. Each bone is connected with one or more bones and are united via a joint (only exception: hyoid bone). With the attached tendons and musculature, the skeleton acts as a lever that drives the force of movement. The inner core of bones (medulla) contains either red bone marrow (primary site of hematopoiesis) or is filled with yellow bone marrow filled with adipose tissue. The main outcomes of bone development are endochondral and membranous forms. This particular characteristic along with the general shape of the bone are used to classify the skeletal system. The main shapes that are recognized include: long short flat sesamoid irregular Types of bone Long bones These bones develop via endochondral ossification, a process in which the hyaline cartilage plate is slowly replaced. A shaft, or diaphysis, connects the two ends known as the epiphyses (plural for epiphysis). -
Histologia Animal
Índex de termes castellans Índex de termes anglesos ácido hialurónico, 1 eosinófi lo, 38 líquido cerebroespinal, 73 proteína estructural, 115 adhesive protein, 114 ectodermic, 33 leucocyte, 59 oogenesis, 105 adipocito, 2 epitelio, 39 macrófago, 74 proteoglucano, 116 adipose tissue, 129 elastic cartilage, 15 leukocyte, 59 osseous tissue, 134 agranulocito, 3 epitelio estratifi cado, 40 mastocito, 75 receptor, 117 adypocite, 2 elastin, 34 lymphocyte, 71 ossifi cation, 107 amielínico –ca, 4 epitelio seudoestratifi cado, 41 matriz extracelular, 76 retículo sarcoplasmático, 118 agranulocyte, 3 electrical synapse, 123 lymphocytopoiesis, 72 osteoblast, 108 amígdala, 5 epitelio simple, 42 medula, 77 sangre, 119 amyelinic, 4 endochondral, 35 lymphoid organs, 106 osteoclast, 110 anticuerpo, 6 eritrocito, 43 médula, 77 sarcómero, 120 amygdala, 5 endocrine gland, 55 lymphopoiesis, 72 osteocyte, 109 APC, 23 eritropoyesis, 44 médula ósea amarilla, 78 sinapsis, 122 animal histology, 66 endoderm, 36 macrophage, 74 peripheral nervous system, 127 axón, 7 espermatogénesis, 45 médula ósea roja, 79 sinapsis eléctrica, 123 antibody, 6 endodermal, 37 marrow, 77 plasma, 112 barrera hematoencefálica, 8 estereocilio, 46 megacariocito, 80 sinapsis química, 124 antigen-presenting cell, 23 endodermic, 37 mast cell, 75 plasma cell, 22 basófi lo –la, 9 fecundación, 47 megacariocitopoyesis, 81 sistema inmunitario, 125 APC, 23 eosinophil, 38 mastocyte, 75 plasmacyte, 22 bazo, 82 fi bra muscular, 48 memoria inmunitaria, 83 sistema nervioso central, 126 axon, 7 eosinophile, 38 -
16 Cartilage
Cartilage Cartilage serves as a rigid yet lightweight and flexible supporting tissue. It forms the framework for the respiratory passages to prevent their collapse, provides smooth "bearings" at joints, and forms a cushion between the vertebrae, acting as a shock absorber for the spine. Cartilage is important in determining the size and shape of bones and provides the growing areas in many bones. Its capacity for rapid growth while maintaining stiffness makes cartilage suitable for the embryonic skeleton. About 75% of the water in cartilage is bound to proteoglycans, and these compounds are important in the transport of fluids, electrolytes, and nutrients throughout the cartilage matrix. Although adapted to provide support, cartilage contains only the usual elements of connective tissue cells, fibers, and ground substance. It is the ground substance that gives cartilage its firm consistency and ability to withstand compression and shearing forces. Collagen and elastic fibers embedded in the ground substance impart tensile strength and elasticity. Together, the fibers and ground substance form the matrix of cartilage. Cartilage differs from other connective tissues in that it lacks nerves, blood and lymphatic vessels and is nourished entirely by diffusion of materials from blood vessels in adjacent tissues. Although relatively rigid, the cartilage matrix has high water content and is freely permeable, even to fairly large particles. Classification of cartilage into hyaline, elastic, and fibrous types is based on differences in the abundance and type of fibers in the matrix. Hyaline Cartilage Hyaline cartilage is the most common type of cartilage and forms the costal cartilages, articular cartilages of joints, and cartilages of the nose, larynx, trachea, and bronchi. -
Cartilage & Bone
Cartilage & bone Red: important. Black: in male|female slides. Gray: notes|extra. Editing File ➢ OBJECTIVES • describe the microscopic structure, distribution and growth of the different types of Cartilage • describe the microscopic structure, distribution and growth of the different types of Bone Histology team 437 | MSK block | Lecture one ➢ REMEMBER from last block (connective tissue lecture) Components of connective tissue Fibers Cells Collagenous, Matrix difference elastic & the intercellular substance, in which types reticular cells and fibers are embedded. Rigid (rubbery, Hard (solid) Fluid (liquid) Soft firm) “Cartilage” “Bone” “Blood” “C.T Proper” Histology team 437 | MSK block | Lecture one CARTILAGE “Chondro- = relating to cartilage” BONE “Osteo- = relating to bone” o Its specialized type of connective tissue with a rigid o Its specialized type of connective tissue with a hard matrix (ﻻ يكسر بسهولة) matrix o Its usually nonvascular (avascular = lack of blood o Types: vessels) 1) Compact bone 2) Spongy bone o Its poor nerve supply o Components: 1) Bone cells: o All cartilage contain collagen fiber type II • Osteogenic cells • Osteoblasts o Types: • Osteocytes 1) Hyaline cartilage (main type) • Osteoclasts 2) Elastic cartilage 2) Bone Matrix (calcified osteoid tissue): 3) Fibrocartilage • hard because it is calcified (Calcium salts) • It contains collagen fibers type I • It forms bone lamellae and trabeculae 3) Periosteum 4) Endosteum o Functions: 1) body support 2) protection of vital organs as brain & bone marrow 3) calcium -
Nomina Histologica Veterinaria, First Edition
NOMINA HISTOLOGICA VETERINARIA Submitted by the International Committee on Veterinary Histological Nomenclature (ICVHN) to the World Association of Veterinary Anatomists Published on the website of the World Association of Veterinary Anatomists www.wava-amav.org 2017 CONTENTS Introduction i Principles of term construction in N.H.V. iii Cytologia – Cytology 1 Textus epithelialis – Epithelial tissue 10 Textus connectivus – Connective tissue 13 Sanguis et Lympha – Blood and Lymph 17 Textus muscularis – Muscle tissue 19 Textus nervosus – Nerve tissue 20 Splanchnologia – Viscera 23 Systema digestorium – Digestive system 24 Systema respiratorium – Respiratory system 32 Systema urinarium – Urinary system 35 Organa genitalia masculina – Male genital system 38 Organa genitalia feminina – Female genital system 42 Systema endocrinum – Endocrine system 45 Systema cardiovasculare et lymphaticum [Angiologia] – Cardiovascular and lymphatic system 47 Systema nervosum – Nervous system 52 Receptores sensorii et Organa sensuum – Sensory receptors and Sense organs 58 Integumentum – Integument 64 INTRODUCTION The preparations leading to the publication of the present first edition of the Nomina Histologica Veterinaria has a long history spanning more than 50 years. Under the auspices of the World Association of Veterinary Anatomists (W.A.V.A.), the International Committee on Veterinary Anatomical Nomenclature (I.C.V.A.N.) appointed in Giessen, 1965, a Subcommittee on Histology and Embryology which started a working relation with the Subcommittee on Histology of the former International Anatomical Nomenclature Committee. In Mexico City, 1971, this Subcommittee presented a document entitled Nomina Histologica Veterinaria: A Working Draft as a basis for the continued work of the newly-appointed Subcommittee on Histological Nomenclature. This resulted in the editing of the Nomina Histologica Veterinaria: A Working Draft II (Toulouse, 1974), followed by preparations for publication of a Nomina Histologica Veterinaria. -
Clinical Outcomes of Elastin Fibre Defects
ytology & f C H i o s l t a o n l o r g u y o Hassan et al., J Cytol Histol 2013, 4:1 J Journal of Cytology & Histology DOI: 10.4172/2157-7099.1000166 ISSN: 2157-7099 CommentaryResearch Article OpenOpen Access Access Clinical Outcomes of Elastin Fibre Defects Ashfaq Ul Hassan1*, Ghulam Hassan2, Zahida Rasool3 and Shabinul Hassan3 1Anatomy Department, SKIMS Medical College, Bemina, Srinagar, Kashmir, India 2Department of Anatomy, Al Qassim University, Saudi Arabia 3Islamic University of Science and Technology, Kashmir, India Abstract Elastic fibres are a major class of extracellular matrix fibres that are abundant in dynamic connective tissues such as arteries, lungs, skin and ligaments. Their structural role is to endow tissues with elastic recoil and resilience. They also act as an important adhesion template for cells, and they regulate growth factor availability. Mutations in major structural components of elastic fibres, especially elastin, fibrillins and fibulin-5, cause severe, often life-threatening, heritable connective tissue diseases such as Marfan syndrome, Menkes Syndrome, Cutis laxa. Elastic-fibre function is also frequently compromised in damaged or aged elastic tissues. The ability to regenerate or engineer elastic fibres and tissues remains a significant challenge, requiring improved understanding of the molecular and cellular basis of elastic-fibre biology and pathology. The aim of the article is to present in brief the structural details of elastin fibres, the defects and pleiotrophic effects as a result of damage and various clinical conditions associated with defects in elastin fibres ranging from rare pediatric syndromes to common entities like hypertension. -
The Distribution of Elastin in Developing and Adult Rat Organs Using Immunocytochemical Techniques
J. Anat. (1989), 165, pp. 225-236 225 With 6 figures Printed in Great Britain The distribution of elastin in developing and adult rat organs using immunocytochemical techniques COLIN FARQUHARSON AND SIMON P. ROBINS Rowett Research Institute, Biochemistry Division, Bucksburn, Aberdeen, Scotland (Accepted 20 December 1988) INTRODUCTION Elastin is the major protein of elastic system fibres, the principal connective tissue components responsible for the elasticity of a number of compliant organs such as aorta and skin. The elastic system fibres include elastic fibres, elaunin fibres and oxytalan fibres (Cotta-Pereira, Rodrigo & Bittencourt-Sampio, 1976). The elastic fibre consists of two morphologically distinct components (Ross & Bornstein, 1969): large amounts of an amorphous elastin core surrounded by a few microfibrils which are glycoprotein in nature (Sear, Grant & Jackson, 1981). Elaunin fibres also contain both components but are composed predominantly of microfibrils with little amorphous elastin, whereas oxytalan fibres are, exclusively, bundles of microfibrils (Cotta-Pereira et al. 1976). Oxytalan and elaunin fibres appear to be precursors of the mature elastic fibre (Gawlik, 1965). By light microscopy, demonstration of elastin has relied on characteristic staining reactions, chiefly with orcein, aldehyde-fuchsin and resorcin-fuchsin based stains. These classical stains do not however provide unequivocal identification of elastin as their specificity is now in doubt (Puchtler, Meloan & Pollard, 1976; Fakan & Saskova, 1982), thus limiting the use of these tinctorial dyes. Recently, there have been a number of reports using immunocytochemical detection of elastin by light microscopy (McCullagh, Barnard, Davies & Partridge, 1980; Barnard et al. 1982a; Barnard, Davies & Young, 1982 b; Fukuda, Ferrans & Crystal, 1983; Akita, Barrach & Merker, 1986). -
Connective Tissue and Mesenchymal Tissue
Connective tissue & mesenchymal tissue Prepared by: Ms. BR Tsauses Anatomical Pathology 2A (ANP611S) April 2020 Learning objectives • Understand connective and mesenchymal tissues in order to describe and apply appropriate staining techniques in Histology. Pre-learning Quiz • Please take the pre-learning quiz before proceeding with the presentation. Introduction • Connective tissue (CT) is of the four tissue types • Derived fom latin word connectere meaning to bind. • Is to connect together and provide support Introduction cont… • During embryonic development: ectoderm + endoderm = mesoderm • This germ layer is known as mesenchymal • Mesos means middle • Enchyma means infusion Connective tissue CT are divided into: 1. Connective tissue proper (dense, areolar, regular,adipose regular and reticular 2. Cartilage (hyaline elastic, fibrocartilage) 3. Bone( spongy or cancellous and dense or cortical) 4. Blood 5. Blood-forming (hematopoietic) Connective tissue cell types • Fibroblast • Mast cells • Histocytes • Adipose cells • Reticulor cells • Osteoblast and osteocytes • Chondroblast and chondrocytes • Blood cells and blood forming cells Intercellular substance • Intercellular substance (ICS) is composed of both amorphous(sulfated and non sulfated mucopolysaccharides) and formed elements (collagen, reticular fibers and elastic fibers) • The nature of these substance varies according its function (hard or dense or soft.) • Classified into: formed or fibrous type : gel or amorphous type Formed or fibrous intercellular substances Collagenenic fibers • Most common ICS found in large quantities in most sites • Appear as individual fibers as in loose areolar tissues e. g tendon • Collagenic fibers do not branch • Collagen types: Type (i) up to (vi) Reticular fibers • Provide bulk of supporting network of more cellular organs e. g spleen, lymph nodes, liver. -
Índice De Denominacións Españolas
VOCABULARIO Índice de denominacións españolas 255 VOCABULARIO 256 VOCABULARIO agente tensioactivo pulmonar, 2441 A agranulocito, 32 abaxial, 3 agujero aórtico, 1317 abertura pupilar, 6 agujero de la vena cava, 1178 abierto de atrás, 4 agujero dental inferior, 1179 abierto de delante, 5 agujero magno, 1182 ablación, 1717 agujero mandibular, 1179 abomaso, 7 agujero mentoniano, 1180 acetábulo, 10 agujero obturado, 1181 ácido biliar, 11 agujero occipital, 1182 ácido desoxirribonucleico, 12 agujero oval, 1183 ácido desoxirribonucleico agujero sacro, 1184 nucleosómico, 28 agujero vertebral, 1185 ácido nucleico, 13 aire, 1560 ácido ribonucleico, 14 ala, 1 ácido ribonucleico mensajero, 167 ala de la nariz, 2 ácido ribonucleico ribosómico, 168 alantoamnios, 33 acino hepático, 15 alantoides, 34 acorne, 16 albardado, 35 acostarse, 850 albugínea, 2574 acromático, 17 aldosterona, 36 acromatina, 18 almohadilla, 38 acromion, 19 almohadilla carpiana, 39 acrosoma, 20 almohadilla córnea, 40 ACTH, 1335 almohadilla dental, 41 actina, 21 almohadilla dentaria, 41 actina F, 22 almohadilla digital, 42 actina G, 23 almohadilla metacarpiana, 43 actitud, 24 almohadilla metatarsiana, 44 acueducto cerebral, 25 almohadilla tarsiana, 45 acueducto de Silvio, 25 alocórtex, 46 acueducto mesencefálico, 25 alto de cola, 2260 adamantoblasto, 59 altura a la punta de la espalda, 56 adenohipófisis, 26 altura anterior de la espalda, 56 ADH, 1336 altura del esternón, 47 adipocito, 27 altura del pecho, 48 ADN, 12 altura del tórax, 48 ADN nucleosómico, 28 alunarado, 49 ADNn, 28