October 6, 2020 u vol. 117 u no. 40

From the Cover

24929 Body growth and dental anomaly in dogs 24634 Metallization of diamond 24735 Antarctic ice shelf damage and instability 24778 Childhood maltreatment and mitochondria 24900 Invasive malaria vector in Africa

Contents

THIS WEEK IN PNAS—This week’s research highlights Cover image: Pictured is a pair of 24603 In This Issue Shetland Sheepdogs exhibiting the body size variation that occurs within this breed. Sydney R. Abrams et al. AT THE NATIONAL ACADEMIES identified two gene variants in Shetland 24606 Don’t let COVID-19 disrupt campus climate surveys of sexual harassment Sheepdogs that were associated with Kathryn J. Holland, Lilia M. Cortina, Vicki J. Magley, Arielle L. Baker, and Frazier F. Benya both reduced body size and a dental anomaly known as lance canine. One of these variants is a splice site mutation in OPINION—Leading scientists discuss current issues the Growth Hormone 1 gene, which has been implicated in human pituitary 24609 We have been in lockdown, but deforestation has not dwarfism, and both variants were Douglas C. Daly frequent in toy dog breeds but absent from larger breeds. The results suggest QNAS—Interviews with leading scientific researchers and newsmakers that the variants may reduce growth and confer risk for lance canine in dogs. See 24612 QnAs with Carlos Taboada the article by Abrams et al. on pages Tinsley H. Davis 24929–24935. Image credit: Nancy Ager (photographer). COMMENTARIES 24614 Low genetic diversity may be an Achilles heel of SARS-CoV-2 Jason W. Rausch, Adam A. Capoferri, Mary Grace Katusiime, Sean C. Patro, and Mary F. Kearney See companion article on page 23652 in issue 38 of volume 117 24617 Ancient agriculture and climate change on the north coast of Peru Jason Nesbitt See companion article on page 24127 in issue 39 of volume 117

PERSPECTIVE 24620 Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics Jonathan Baruch Steinman, Fok Moon Lum, Peggy Pui-Kay Ho, Naftali Kaminski, and Lawrence Steinman

LETTERS 24627 Turning to Drosophila for help in resolving general anesthesia Bruno van Swinderen and Adam D. Hines

Free online through the PNAS open access option. PNAS u October 6, 2020 u vol. 117 u no. 40 u iii–vii Downloaded by guest on September 25, 2021 24629 Reply to van Swinderen and Hines: Drosophila model CHEMISTRY establishes the lipid membrane as a target 24679 Computational generation of an annotated gigalibrary of anesthetics of synthesizable, composite peptidic macrocycles Scott B. Hansen, Richard A. Lerner, Mahmud Arif Pavel, Ishika Saha, Eric K. Dang, Dennis Svatunek, Kendall N. Houk, and E. Nicholas Petersen and Patrick G. Harran 24630 Bitter gourd from Africa expanded to Southeast Asia 24691 Distinct hypertrophic cardiomyopathy genotypes and was domesticated there: A new insight from result in convergent sarcomeric proteoform parallel studies profiles revealed by top-down proteomics Susanne S. Renner Trisha Tucholski, Wenxuan Cai, Zachery R. Gregorich, 24632 Reply to Renner: Meticulous investigation, not Elizabeth F. Bayne, Stanford D. Mitchell, Sean J. McIlwain, sequencing effort, leads to robust conclusion Willem J. de Lange, Max Wrobbel, Hannah Karp, Zachary Hite, Petr G. Vikhorev, Steven B. Marston, Sean Lal, Amy Li, Cristobal Hideo Matsumura, Min-Chien Hsiao, Ya-Ping Lin, Atsushi dos Remedios, Takushi Kohmoto, Joshua Hermsen, J. Carter Toyoda, Naoki Taniai, Kazuhiko Tarora, Naoya Urasaki, Ralphe, Timothy J. Kamp, Richard L. Moss, and Ying Ge Shashi S. Anand, Narinder P. S. Dhillon, Roland Schafleitner, and Cheng-Ruei Lee 24701 Unraveling nucleation pathway in methane clathrate formation Liwen Li, Jie Zhong, Youguo Yan, Jun Zhang, Jiafang Xu, INAUGURAL ARTICLE Joseph S. Francisco, and Xiao Cheng Zeng 24634 Metallization of diamond 24794 Studies of lincosamide formation complete the Zhe Shi, Ming Dao, Evgenii Tsymbalov, Alexander Shapeev, biosynthetic pathway for lincomycin A Ju Li, and Subra Suresh Shao-An Wang, Chia-I Lin, Jiawei Zhang, Richiro Ushimaru, Eita Sasaki, and Hung-wen Liu BRIEF REPORTS COMPUTER SCIENCES 24640 America’s electorate is increasingly polarized along partisan lines about voting by mail during the 24709 Enabling early detection of osteoarthritis from COVID-19 crisis presymptomatic cartilage texture maps via Mackenzie Lockhart, Seth J. Hill, Jennifer Merolla, Mindy transport-based learning Romero, and Thad Kousser Shinjini Kundu, Beth G. Ashinsky, Mustapha Bouhrara, Erik B. Dam, Shadpour Demehri, Mohammad Shifat-E-Rabbi, 24643 Extraordinary flight performance of the Richard G. Spencer, Kenneth L. Urish, and Gustavo K. Rohde smallest beetles Сергей Фарисенков Sergey E. Farisenkov ( ), Nadejda A. EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Lapina (НадеждаЛапина), Pyotr N. Petrov (Пётр Петров), and Alexey A. Polilov (Алексей Полилов) 24720 Microbial biomarkers reveal a hydrothermally active landscape at Olduvai Gorge at the dawn of the 24646 Assessing the ecological niche and invasion potential Acheulean, 1.7 Ma of the Asian giant hornet Ainara Sistiaga, Fatima Husain, David Uribelarrea, David M. Gengping Zhu, Javier Gutierrez Illan, Chris Looney, Martı´n-Perea, Troy Ferland, Katherine H. Freeman, Fernando and David W. Crowder Diez-Martı´n, Enrique Baquedano, Audax Mabulla, Manuel 24649 Tree planting has the potential to increase Domı´nguez-Rodrigo, and Roger E. Summons carbon sequestration capacity of forests 24729 The 3.6-Ma aridity and westerlies history over in the United States midlatitude Asia linked with global climatic cooling Grant M. Domke, Sonja N. Oswalt, Brian F. Walters, Xiaomin Fang, Zhisheng An, Steven C. Clemens, Jinbo Zan, and Randall S. Morin Zhengguo Shi, Shengli Yang, and Wenxia Han 24735 Damage accelerates ice shelf instability and mass loss PHYSICAL SCIENCES in Amundsen Sea Embayment Stef Lhermitte, Sainan Sun, Christopher Shuman, Bert Wouters, APPLIED MATHEMATICS Frank Pattyn, Jan Wuite, Etienne Berthier, and Thomas Nagler 24652 Prevalence of neural collapse during the terminal 24742 Localized foundering of Indian lower crust in the phase of deep learning training India–Tibet collision zone Vardan Papyan, X. Y. Han, and David L. Donoho Danian Shi, Simon L. Klemperer, Jianyu Shi, Zhenhan Wu, and Wenjin Zhao APPLIED PHYSICAL SCIENCES – 24664 Tunable layered-magnetism assisted magneto- ENGINEERING Raman effect in a two-dimensional magnet CrI 3 24748 Carbon nitride-based light-driven microswimmers Wencan Jin, Zhipeng Ye, Xiangpeng Luo, Bowen Yang, Gaihua Ye, Fangzhou Yin, Hyun Ho Kim, Laura Rojas, Shangjie Tian, with intrinsic photocharging ability Yang Fu, Shaohua Yan, Hechang Lei, Kai Sun, Adam W. Tsen, Varun Sridhar, Filip Podjaski, Julia Kro¨ger, Alberto Jime´nez- Rui He, and Liuyan Zhao Solano, Byung-Wook Park, Bettina V. Lotsch, and Metin Sitti

BIOPHYSICS AND COMPUTATIONAL BIOLOGY MATHEMATICS 24670 Stick–slip model for actin-driven cell protrusions, cell 24757 Stable homotopy groups of spheres polarization, and crawling Daniel C. Isaksen, Guozhen Wang, and Zhouli Xu Pierre Sens 25066 Learning probabilistic neural representations with PHYSICS randomly connected circuits 24634 Metallization of diamond Ori Maoz, Gasper Tkacik, Mohamad Saleh Esteki, Roozbeh Zhe Shi, Ming Dao, Evgenii Tsymbalov, Alexander Shapeev, Kiani, and Elad Schneidman Ju Li, and Subra Suresh

iv u www.pnas.org Contents Downloaded by guest on September 25, 2021 24764 Strain engineering of the charge and spin-orbital 24802 A phenolic small molecule inhibitor of RNase L interactions in Sr2IrO4 prevents cell death from ADAR1 deficiency Eugenio Paris, Yi Tseng, Ekaterina M. Pa¨rschke, Salima Daou, Manisha Talukdar, Jinle Tang, Beihua Dong, Wenliang Zhang, Mary H. Upton, Anna Efimenko, Shuvojit Banerjee, Yize Li, Nicole M. Duffy, Abiodun A. Katharina Rolfs, Daniel E. McNally, Laura Maurel, Muntaser Ogunjimi, Christina Gaughan, Babal K. Jha, Gerald Gish, Naamneh, Marco Caputo, Vladimir N. Strocov, Zhiming Nicolas Tavernier, Daniel Mao, Susan R. Weiss, Hao Huang, Wang, Diego Casa, Christof W. Schneider, Ekaterina Robert H. Silverman, and Frank Sicheri Pomjakushina, Krzysztof Wohlfeld, Milan Radovic, 24813 Chelicerata sDscam isoforms combine homophilic and Thorsten Schmitt specificities to define unique cell recognition Fengyan Zhou, Guozheng Cao, Songjun Dai, Guo Li, Hao Li, SOCIAL SCIENCES Zhu Ding, Shouqing Hou, Bingbing Xu, Wendong You, Gil Wiseglass, Feng Shi, Xiaofeng Yang, Rotem Rubinstein, ANTHROPOLOGY and Yongfeng Jin 24720 Microbial biomarkers reveal a hydrothermally active 24825 The cytoplasmic tail of human mannosidase Man1b1 landscape at Olduvai Gorge at the dawn of the contributes to catalysis-independent quality control Acheulean, 1.7 Ma of misfolded alpha1-antitrypsin Ainara Sistiaga, Fatima Husain, David Uribelarrea, David M. Ashlee H. Sun, John R. Collette, and Richard N. Sifers Martı´n-Perea, Troy Ferland, Katherine H. Freeman, Fernando Diez-Martı´n, Enrique Baquedano, Audax Mabulla, Manuel BIOPHYSICS AND COMPUTATIONAL BIOLOGY Domı´nguez-Rodrigo, and Roger E. Summons 24679 Computational generation of an annotated gigalibrary 24909 Accelerated reproduction is not an adaptive of synthesizable, composite peptidic macrocycles response to early-life adversity in Ishika Saha, Eric K. Dang, Dennis Svatunek, Kendall N. Houk, wild baboons and Patrick G. Harran Chelsea J. Weibel, Jenny Tung, Susan C. Alberts, and Elizabeth A. Archie 24837 Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception ECONOMIC SCIENCES – Deepanshu Choudhary, Yoshie Narui, Brandon L. Neel, 24771 Catch quota matching allowances balance economic Lahiru N. Wimalasena, Carissa F. Klanseck, Pedro De-la-Torre, and ecological targets in a fishery managed by Conghui Chen, Raul Araya-Secchi, Elakkiya Tamilselvan, individual transferable quota and Marcos Sotomayor Maartje Oostdijk, Conor Byrne, Gunnar Stefa´nsson, Maria J. 24849 DNA binding induces a cis-to-trans switch in Cre Santos, and Pamela J. Woods recombinase to enable intasome assembly 25169 A map of decoy influence in human Aparna Unnikrishnan, Carlos Amero, Deepak Kumar Yadav, multialternative choice Kye Stachowski, Devante Potter, and Mark P. Foster Tsvetomira Dumbalska, Vickie Li, Konstantinos Tsetsos, and Christopher Summerfield CELL BIOLOGY 24859 Targeting the histone demethylase PHF8-mediated PSYCHOLOGICAL AND COGNITIVE SCIENCES PKCα-Src-PTEN axis in HER2-negative 24778 Childhood maltreatment is associated with changes gastric cancer in mitochondrial bioenergetics in maternal, but not Lin-Lu Tseng, Hsin-Hung Cheng, Ta-Sen Yeh, Shih-Chiang in neonatal immune cells Huang, Ya-Yun Syu, Chih-Pin Chuu, Chiou-Hwa Yuh, Hsing-Jien Anja M. Gumpp, Christina Boeck, Alexander Behnke, Kung, and Wen-Ching Wang Alexandra M. Bach, Laura Ramo-Ferna´ndez, Thilo Welz, Harald Gu¨ndel, Iris-Tatjana Kolassa, and Alexander Karabatsiakis 24867 Vitamin A aldehyde-taurine adduct and the visual cycle Hye Jin Kim, Jin Zhao, and Janet R. Sparrow SOCIAL SCIENCES 24785 Decoding the mystery of American pain reveals a warning for the future DEVELOPMENTAL BIOLOGY Anne Case, Angus Deaton, and Arthur A. Stone 24876 Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer Lindsey Barske, Peter Fabian, Christine Hirschberger, David BIOLOGICAL SCIENCES Jandzik, Tyler Square, Pengfei Xu, Nellie Nelson, Haoze Vincent Yu, Daniel M. Medeiros, J. Andrew Gillis, AGRICULTURAL SCIENCES and J. Gage Crump 24790 Detection of SARS-CoV-2 in a cat owned by a COVID- − 19 affected patient in Spain ECOLOGY Joaquim Segale´s, Mariona Puig, Jordi Rodon, Carlos Avila- 24885 Rhizosphere activity in an old-growth forest reacts Nieto, Jorge Carrillo, Guillermo Cantero, Maria Teresa Terro´n, Sı´lvia Cruz, Mariona Parera, Marc Noguera-Julia´n, Nuria rapidly to changes in soil moisture and shapes Izquierdo-Useros, Vı´ctor Guallar, Enric Vidal, Alfonso Valencia, whole-tree carbon allocation Ignacio Blanco, Julia` Blanco, Bonaventura Clotet, Jobin Joseph, Decai Gao, Bernhard Backes, Corinne Bloch, and Ju´lia Vergara-Alert Ivano Brunner, Gerd Gleixner, Matthias Haeni, Henrik Hartmann, Gu¨nter Hoch, Christian Hug, Ansgar Kahmen, Marco M. Lehmann, Mai-He Li, Jo¨rg Luster, Martina Peter, BIOCHEMISTRY Christian Poll, Andreas Rigling, Kaisa A. Rissanen, Nadine K. 24794 Studies of lincosamide formation complete the Ruehr, Matthias Saurer, Marcus Schaub, Leonie Scho¨nbeck, biosynthetic pathway for lincomycin A Benjamin Stern, Frank M. Thomas, Roland A. Werner, Willy Shao-An Wang, Chia-I Lin, Jiawei Zhang, Richiro Ushimaru, Eita Werner, Thomas Wohlgemuth, Frank Hagedorn, Sasaki, and Hung-wen Liu and Arthur Gessler

Contents PNAS u October 6, 2020 u vol. 117 u no. 40 u v Downloaded by guest on September 25, 2021 24893 Heterotrophic eukaryotes show a slow-fast 24964 Influenza A virus causes maternal and fetal pathology continuum, not a gleaner–exploiter trade-off via innate and adaptive vascular inflammation in mice Thomas Kiørboe and Mridul K. Thomas Stella Liong, Osezua Oseghale, Eunice E. To, Kurt Brassington, Jonathan R. Erlich, Raymond Luong, Felicia Liong, Robert Brooks, Cara Martin, Sharon O’Toole, Antony Vinh, Luke A. J. ENVIRONMENTAL SCIENCES O’Neill, Steven Bozinovski, Ross Vlahos, Paris C. Papagianis, 24771 Catch–quota matching allowances balance economic John J. O’Leary, Doug A. Brooks, and Stavros Selemidis and ecological targets in a fishery managed by 24974 Endoplasmic reticulum chaperones stabilize ligand- individual transferable quota receptive MR1 molecules for efficient presentation Maartje Oostdijk, Conor Byrne, Gunnar Stefa´nsson, Maria J. of metabolite antigens Santos, and Pamela J. Woods Hamish E. G. McWilliam, Jeffrey Y. W. Mak, Wael Awad, 24900 A new malaria vector in Africa: Predicting the Matthew Zorkau, Sebastian Cruz-Gomez, Hui Jing Lim, Yuting expansion range of Anopheles stephensi and Yan, Sam Wormald, Laura F. Dagley, Sidonia B. G. Eckle, identifying the urban populations at risk Alexandra J. Corbett, Haiyin Liu, Shihan Li, Scott J. J. Reddiex, Justine D. Mintern, Ligong Liu, James McCluskey, Jamie M. E. Sinka, S. Pironon, N. C. Massey, J. Longbottom, J. Rossjohn, David P. Fairlie, and Jose A. Villadangos Hemingway, C. L. Moyes, and K. J. Willis 24986 Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases EVOLUTION Gonzalo Fernandez Lahore, Bruno Raposo, Marie Lagerquist, 24909 Accelerated reproduction is not an adaptive Claes Ohlsson, Pierre Sabatier, Bingze Xu, Mike Aoun, Jaime response to early-life adversity in James, Xiaojie Cai, Roman A. Zubarev, Kutty Selva wild baboons Nandakumar, and Rikard Holmdahl Chelsea J. Weibel, Jenny Tung, Susan C. Alberts, 24998 CD8 T cells drive anorexia, dysbiosis, and blooms of and Elizabeth A. Archie a commensal with immunosuppressive potential 24920 Australian funnel-web spiders evolved human-lethal after viral infection δ-hexatoxins for defense against Lara Labarta-Bajo, Anna Gramalla-Schmitz, Romana R. Gerner, vertebrate predators Katelynn R. Kazane, Gregory Humphrey, Tara Schwartz, Volker Herzig, Kartik Sunagar, David T. R. Wilson, Sandy S. Karenina Sanders, Austin Swafford, Rob Knight, Manuela Pineda, Mathilde R. Israel, Sebastien Dutertre, Brianna Sollod Raffatellu, and Elina I. Zu´n˜iga McFarland, Eivind A. B. Undheim, Wayne C. Hodgson, Paul F. 25008 14-3-3ζ–TRAF5 axis governs interleukin-17A signaling Alewood, Richard J. Lewis, Frank Bosmans, Irina Vetter, Jenna McGowan, Cara Peter, Joshua Kim, Sonam Popli, Brent Glenn F. King, and Bryan G. Fry Veerman, Jessica Saul-McBeth, Heather Conti, Shondra M. Pruett-Miller, Saurabh Chattopadhyay, and Ritu Chakravarti GENETICS 25018 Systemic complement activation is associated with 24929 Variants in FtsJ RNA 2′-O-Methyltransferase 3 and respiratory failure in COVID-19 hospitalized patients Growth Hormone 1 are associated with small Jan C. Holter, Soeren E. Pischke, Eline de Boer, Andreas Lind, Synne body size and a dental anomaly in dogs Jenum, Aleksander R. Holten, Kristian Tonby, Andreas Barratt-Due, Sydney R. Abrams, Alexandra L. Hawks, Jacquelyn M. Evans, Marina Sokolova, Camilla Schjalm, Viktoriia Chaban, Anette Thomas R. Famula, Mary Mahaffey, Gary S. Johnson, Kolderup, Trung Tran, Torleif Tollefsrud Gjølberg, Linda G. Skeie, Liv Jennifer M. Mason, and Leigh Anne Clark Hesstvedt, Vidar Orma˚sen, Børre Fevang, Cathrine Austad, Karl Erik Mu¨ller, Cathrine Fladeby, Mona Holberg-Petersen, Bente 24936 Unusually efficient CUG initiation of an overlapping Halvorsen, Fredrik Mu¨ller, Pa˚l Aukrust, Susanne Dudman, Thor reading frame in POLG mRNA yields novel Ueland, Jan Terje Andersen, Fridtjof Lund-Johansen, Lars protein POLGARF Heggelund, Anne M. Dyrhol-Riise, and Tom E. Mollnes Gary Loughran, Alexander V. Zhdanov, Maria S. Mikhaylova, Fedor N. Rozov, Petr N. Datskevich, Sergey I. MEDICAL SCIENCES Kovalchuk, Marina V. Serebryakova, Stephen J. Kiniry, 24691 Distinct hypertrophic cardiomyopathy genotypes Audrey M. Michel, Patrick B. F. O’Connor, Dmitri B. Papkovsky, result in convergent sarcomeric proteoform John F. Atkins, Pavel V. Baranov, Ivan N. Shatsky, profiles revealed by top-down proteomics and Dmitry E. Andreev Trisha Tucholski, Wenxuan Cai, Zachery R. Gregorich, 24947 Trajectory and uniqueness of mutational signatures in Elizabeth F. Bayne, Stanford D. Mitchell, Sean J. McIlwain, yeast mutators Willem J. de Lange, Max Wrobbel, Hannah Karp, Zachary Hite, Sophie Loeillet, Mareike Herzog, Fabio Puddu, Patricia Petr G. Vikhorev, Steven B. Marston, Sean Lal, Amy Li, Cristobal Legoix, Sylvain Baulande, Stephen P. Jackson, dos Remedios, Takushi Kohmoto, Joshua Hermsen, J. Carter and Alain G. Nicolas Ralphe, Timothy J. Kamp, Richard L. Moss, and Ying Ge 24709 Enabling early detection of osteoarthritis from presymptomatic cartilage texture maps via IMMUNOLOGY AND INFLAMMATION transport-based learning 24778 Childhood maltreatment is associated with changes Shinjini Kundu, Beth G. Ashinsky, Mustapha Bouhrara, Erik B. in mitochondrial bioenergetics in maternal, but not Dam, Shadpour Demehri, Mohammad Shifat-E-Rabbi, in neonatal immune cells Richard G. Spencer, Kenneth L. Urish, and Gustavo K. Rohde Anja M. Gumpp, Christina Boeck, Alexander Behnke, 25026 Circulating testican-2 is a podocyte-derived marker Alexandra M. Bach, Laura Ramo-Ferna´ndez, Thilo Welz, Harald of kidney health Gu¨ndel, Iris-Tatjana Kolassa, and Alexander Karabatsiakis Debby Ngo, Donghai Wen, Yan Gao, Michelle J. Keyes, Erika R. 24957 An apoptosis-dependent checkpoint for Drury, Dan H. Katz, Mark D. Benson, Sumita Sinha, Dongxiao Shen, autoimmunity in memory B and plasma cells Laurie A. Farrell, Bennet D. Peterson, David J. Friedman, Sammy Christian T. Mayer, Jan P. Nieke, Anna Gazumyan, Melissa Elmariah, Bessie A. Young, J. Gustav Smith, Qiong Yang, Cipolla, Qiao Wang, Thiago Y. Oliveira, Victor Ramos, Ramachandran S. Vasan, Martin G. Larson, Adolfo Correa, Se´bastien Monette, Quan-Zhen Li, M. Eric Gershwin, Hamid Benjamin D. Humphreys, Thomas J. Wang, Martin R. Pollak, Kashkar, and Michel C. Nussenzweig James G. Wilson, Robert E. Gerszten, and Eugene P. Rhee

vi u www.pnas.org Contents Downloaded by guest on September 25, 2021 25036 Development of a serum miRNA panel for detection 25138 Convergent molecular, cellular, and cortical neuroimaging of early stage non-small cell lung cancer signatures of major depressive disorder Lisha Ying, Lingbin Du, Ruiyang Zou, Lei Shi, Nan Zhang, Jiaoyue Kevin M. Anderson, Meghan A. Collins, Ru Kong, Kacey Fang, Jin, Chenyang Xu, Fanrong Zhang, Chen Zhu, Junzhou Wu, Jingwei Li, Tong He, Adam M. Chekroud, B. T. Thomas Yeo, Kaiyan Chen, Minran Huang, Yingxue Wu, Yimin Zhang, Weihui and Avram J. Holmes Zheng, Xiaodan Pan, Baofu Chen, Aifen Lin, John Kit Chung Tam, Rob Martinus van Dam, David Tien Min Lai, Kee Seng Chia, Lihan Zhou, Heng-Phon Too, Herbert Yu, Weimin Mao, and Dan Su PLANT BIOLOGY 25150 Longin R-SNARE is retrieved from the plasma MICROBIOLOGY membrane by ANTH domain-containing 25043 Integrated chromosomal and plasmid sequence proteins in Arabidopsis analyses reveal diverse modes of carbapenemase Masaru Fujimoto, Kazuo Ebine, Kohji Nishimura, Nobuhiro gene spread among Klebsiella pneumoniae Tsutsumi, and Takashi Ueda Sophia David, Victoria Cohen, Sandra Reuter, Anna E. Sheppard, Tommaso Giani, Julian Parkhill, the European POPULATION BIOLOGY Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group, the ESCMID Study Group for 25159 Ecological divergence and hybridization of Epidemiological Markers (ESGEM), Gian Maria Rossolini, Neotropical Leishmania parasites Edward J. Feil, Hajo Grundmann, and David M. Aanensen Frederik Van den Broeck, Nicholas J. Savill, Hideo Imamura, 25055 Early termination of the Shiga toxin transcript Mandy Sanders, Ilse Maes, Sinclair Cooper, David Mateus, Marlene Jara, Vanessa Adaui, Jorge Arevalo, Alejandro Llanos- generates a regulatory small RNA Cuentas, Lineth Garcia, Elisa Cupolillo, Michael Miles, Brandon M. Sy, Ruiting Lan, and Jai J. Tree Matthew Berriman, Achim Schnaufer, James A. Cotton, and Jean-Claude Dujardin NEUROSCIENCE 25066 Learning probabilistic neural representations with randomly connected circuits PSYCHOLOGICAL AND COGNITIVE SCIENCES Ori Maoz, Gasper Tkacik, Mohamad Saleh Esteki, Roozbeh 25169 A map of decoy influence in human Kiani, and Elad Schneidman multialternative choice 25074 Transcription factor expression defines subclasses of Tsvetomira Dumbalska, Vickie Li, Konstantinos Tsetsos, and Christopher Summerfield developing projection neurons highly similar to single-cell RNA-seq subtypes Whitney E. Heavner, Shaoyi Ji, James H. Notwell, Ethan S. Dyer, Alex M. Tseng, Johannes Birgmeier, Boyoung Yoo, Gill CORRECTIONS Bejerano, and Susan K. McConnell 25085 GRIP1 regulates synaptic plasticity and learning APPLIED PHYSICAL SCIENCES and memory 25179 Dimple drainage before the coalescence of a droplet Han L. Tan, Shu-Ling Chiu, Qianwen Zhu, deposited on a smooth substrate and Richard L. Huganir Laurent Duchemin and Christophe Josserand 25092 Astroglial FMRP deficiency cell-autonomously up- regulates miR-128 and disrupts developmental DEVELOPMENTAL BIOLOGY astroglial mGluR5 signaling 25180 Enhancer evolutionary co-option through shared Yuqin Men, Liang Ye, Ryan D. Risgaard, Vanessa Promes, Xinyu chromatin accessibility input Zhao, Martin Paukert, and Yongjie Yang Yaqun Xin, Yann Le Poul, Liucong Ling, Mariam Museridze, Bettina Muhling, Rita Jaenichen, Elena Osipova, 25104 Quality-control mechanisms targeting translationally ¨ and Nicolas Gompel stalled and C-terminally extended poly(GR) associated with ALS/FTD GENETICS Shuangxi Li, Zhihao Wu, Ishaq Tantray, Yu Li, Songjie Chen, Jason Dong, Steven Glynn, Hannes Vogel, Michael Snyder, 25181 Natural cryptic variation in epigenetic modulation of and Bingwei Lu an embryonic gene regulatory network Chee Kiang Ewe, Yamila N. Torres Cleuren, Sagen 25116 Ventromedial prefrontal area 14 provides opposing E. Flowers, Geneva Alok, Russell G. Snell, regulation of threat and reward-elicited responses and Joel H. Rothman in the common marmoset Zuzanna M. Stawicka, Roohollah Massoudi, Nicole K. Horst, MEDICAL SCIENCES Ken Koda, Philip L. R. Gaskin, Laith Alexander, Andrea M. 25182 Regulation of T cell activation, anxiety, and male Santangelo, Lauren McIver, Gemma J. Cockcroft, Christian M. aggression by RGS2 Wood, and Angela C. Roberts Antonio J. Oliveira-dos-Santos, Goichi Matsumoto, Bryan E. 25128 Melatonin promotes sleep by activating the BK Snow, Donglin Bai, Frank P. Houston, Ian Q. Whishaw, Sanjeev channel in C. elegans Mariathasan, Takehiko Sasaki, Andrew Wakeham, Pamela S. Longgang Niu, Yan Li, Pengyu Zong, Ping Liu, Yuan Shui, Bojun Ohashi, John C. Roder, Carol A. Barnes, David P. Siderovski, Chen, and Zhao-Wen Wang and Josef M. Penninger

Contents PNAS u October 6, 2020 u vol. 117 u no. 40 u vii Downloaded by guest on September 25, 2021