:16, 3 Np les (Ind No les

OBITUARI ES

H. W. Wade 1886 - 1968

master in histopathologic technic, was to serve him in good stead all his life. In 1908 he moved to Montreal, Canada, as assistant to one of Mall ory's former associates, Charles W. Duval, who had left Mallory's laboratories to become pathologist at the ~vlontrea l General Hospital, with teaching duties at McGill University. In Montreal \Vade served as demonstrator in histology. In 1909 he moved to New Orleans, Louisi­ ana, with Duval, who had been call ed to Tulane University as professor of patholo­ gy. At Tulane "Vade continued his under­ graduate study of medicine, which he had commenced at McGill, serving at the same time as student demonstrator in pathology. lIe graduated in medicine in 1912 and served for three more years as instructor in pathology at Tulane and resident in pathol­ ogy at the old and famous Charity"J-Jospital of New Orleans. In New Orleans he became interested in the pathology of leprosy. His chief, Dr. Duval, was deeply engaged in resear( h on the etiologic agent of the disease, and was Herbert Windsor Wade, eminent in­ one of many who isolated from lepro'iy vestigator of leprosy, third pres ident of the patients an acid-fast bacillus considered for International Leprosy Association a brief period as possibly its in citing agent. ( 1946-1963 ), founder and editcr of the During this period Wade developed a close I NTEHNATlONAL JOUlINAL OF LEPHOSY from working arrangement with the then rela­ its inception until his retirement, and for tively primitive but now well equipped many years Medical Director of the Leon­ leprosy institution at Carville, Louisiana. ard ' ''' ood Memorial for the Eradication of In 1915 Wade married Dorothy Paul of Leprosy, died on 8 June 1968, at the age of New Orleans. Late in that year he ac­ 81, at Culion, in the Philippines, where he cepted an invitation to become pathologist­ had worked on leprosy prohlems for nearl y bacteriologist in the Burcau of Science in half a century. Manila. He and Mrs. Wade reached the Born in 1886, Wade began his scientific Philippines earl y in ]916, and there began work in 1906 as a tissue pathologist in the Wade's lasting dedication to the control of laboratories of the distinguished histopath­ leprosy and leprosy research. lIe was soon ologist Frank B. Mallory of the Boston City appointed to the chairmanship of th e Lep­ Hospital. His training under Mallory, a rosy Examining Committee of th e Bureau 350 Tntemational jOtl1'l1al of Leprosy 1968 of Health of ~ 1::tnil a , a positi oll tll at callcJ pathology, and practical problems of lepro­ for intensive stu dy of di agnostic proce­ sy. Hi s "'ork in these fi elds was performed dures. In the course of his studies in this in Culi on, hut hi s concepts and much of the fi eld he developed the now well -known pathologic materi al on which they were "scraped-incision" method of making skin based resulted from his world-wide travels smears for detecting leprosy bacilli. It was and observations of leprosy in many lands. th e first of Wade's signifi cant accomplish­ Few men, if any, in our time have had a ments in the fi eld of leprosy in ves tigation better perspective on leprosy problems and control. than Wade, and, sin ce he was as critical of In 1918 he accepted an academic ap­ his own research as he was of that of p.ointment as head of the Department of others, it is not ove rl y biased to note his Pathology and Bacteriology in th :;) College own assessment of his accomplishments in of Medi cin e and Surgery of the Uni versity leprosy research. These, in the order set of the Philippines. Here he acquired a rich fo rth by Wade himself in a letter to me in background in tropical medi cine. 1963, were his "scraped-incision" method, In 1922 the Wades moved to what be­ cited above, his studies on tuberculoid lep­ came th eir permanent home, the small is­ rosy and its identification as a major polar land of Culion in the distant province of type of the disease, his later emphasis, with Palawan, one of the southernmos t islands of his associate J. N. Rodriguez, on the "bor­ the Philippine archipelago. It was the seat derline" form of leprosy as a classifiable of what was then designated as the Culion va ri ety of the disease, his pioneer investi ga­ Leper Colon y, now the Culion Sanitarium. tions of the histoid variety of lepromatous The story of Wade's transfer to Culion has leprosy, and, fin ally, in the fi eld of immu­ been told in these pages before, l and need nology, his extensive work on lepromin, not be repeated at length here. The move which included his own special technic for was an outgrowth of Wade's developing making it, and on the lepromin reaction. scientifi c interes t in leprosy, and the Of paJ·ticular significance in this long growing concern, at the same time, of Ma­ record of accomplishment were his estab­ jor General Leonard Wood, Governor Gen­ lishment of the Leonard Wood Memorial eral of the Islands, and himself a physician, Research Laboratory at CuI ion, one of the in leprosy as a seri ous public health prob­ world's most productive centers in this lem. Wade made the move at "Vood's invi­ fi eld, and his initial participation in the tati on with appointment as pathologist and organization of long continued studies by acting chief physician, taking with him a the Memorial of the epidemiology of lepro­ handpicked medical and nursing staff from sy and the clinical evaluation of a series .Jf the Philippine General Hospital in Manila. drugs used in its treatment. Among those selected was Dr. Jose N. The impact of the Leonard Wood Mem­ Rodriguez, with whom W ade was closely orial Research Laboratory at Culion on the associated the rest of his life. investi gation of leprosy extended much be­ Out of that association with General yond these fi elds. Among many studies at Wood and in large measure through the th e Laboratory were those of Dr. John H. efforts of Mrs. W ade in raisin g the neces­ Hanks, who was assigned to the Laboratory sary funds in the United States, came the by the Memorial in 1939. Hanks' studies on Leonard Wood Memorial for the Eradica­ the culture, growth and metabolism of the tion of Leprosy, of which W ade was the leprosy bacillus, which commenced in first medical director. 2 From 1922 until his declining years Wade carried out an unprecedented series 2 An accollnt of thc history of thc Lconard W ood of investigations on the natural history, Mcmorial, and W adc's long and ac ti ve work on its behalf, has also appeared previously in T H E JOU R· NAL: Long. E. R . Forty Years of Lcp rosy Research. History of the Leonard Wood Memori al (Amcrican 1 LONG, E. R .. H . W . WAnE, M.D., Editor Emcri· Lcprosy Foundation) 1928·1967. Internal. J. Lcprosy !Us. Intcrn<.tt. J. Lcprosy 32 (1964) 73·77. 35 (1967) 239·310. (part 2) . 36,3 Obituaries 351

Wade's laboratori es at Culion, and are con­ fone therapy, the tuberculoid amI bordcr­ tinuing at the Leonard Wood Memorial line forms of leprosy, the relative infec­ Laboratories at the Johns H opkins Univer­ tiousness of the different forms of the dis­ sity in Baltimore, have proved of great ease, the classificati on of leprosy, its epide­ significance for the development of this miology, the relations of heredity to suscep­ fi eld, and stimulated much research else­ tibility, attempts at the cultivati on of M. where. leprae, the lepromin and related reactions, Wade's relations with the International BCG in the prevention of leprosy, the Leprosy Association were at all times cl ose. morphology of dead and livin g bacilli, and H e was elected its president in 1946, suc­ numerous technical problems in its patholo­ ceeding E mile Marchoux of the Pasteur gy. Hegularl y there were info rmative edito­ Institute, Paris, who had followed the origi­ ri al analyses of the highlights of each inter­ nal president, Victor H eiser of the Intem a­ national oongress. tional Health Division of the Hockefeller Wade was a steady contributor of re­ Foundation. H eiser had served as di'rector search articles, himself, in the pages of the of health in the Philippines and been in­ INTERNATIONAL JOURNAL OF LEPROSY. A list strumental in founding the leprosy colony of his scientific papers is appended to this at Culion. W ade's influence on the Interna­ biographic memorial. It is included partly tional Leprosy Association, and its mem­ as a record of his accomplishment, but bers personally, was at all times great. equall y because it records the names of One of his chief contributions to the associates with whom he worked , many of study of leprosy was his long editorship of whom are leaders today, tracing much of the INTERNATIONA L JOURNA L OF LEPHOSY. their origin al inspirati on and training to his The well-known Conference on Leprosy influence. called by the Leonard Wood Memorial in In W ade's long and productive career Manila in 1931,3 of which W ade was chair­ pel'haps the most impressive element was man, resulted in the foundation of the his sustained deep interest in leprosy. His International Leprosy Association, and a contributions in this fi eld were based fun­ decision to establish as its official organ the damentall y on his knowledge of pathology. INTEHNATIONAL JOUHNA L OF LEPTIOSY. Wade He ranged the length and breadth of lepro­ was appointed editor. The first issue camc sy problems, including its clinical, epidemi­ out in 1933. The journal served a recog­ ologic and social aspects, but to the end his nized need for the publication of significant views were an outgrowth of his intimate research on leprosy, and it served also as a knowledge of the reacti ons between host forum for the active mind of its editor. His and parasite as he saw them expressed in long seri es of editorials, commencing with a the tissues and fluids of the human body. statement on the International Leprosy As­ He was a meticulous observer, and a very sociation and the INTERNATIONAL JOUHNAL thoughtful one. OF LEPHOSY in its first issue, and ending 'Nade was dedicated to accuracy, not ( except for minOT notes) with a remarkable onl y in his own work, but in that of o1'hers. analysis of the lysosome in leprosy, fur­ His correspondence with authors of papers nishes an impressive outlook on problems, submitted to him as an editor was replete controvers,ies, and progress in more than 30 with insistence on check and recheck, and years of intensive study of leprosy all over suggestions for improvement. To this was the world. added a continued resolute stand on gram­ His editorial analvses illustrate the matical accumcy and a respectable literary breadth of his vision. Covered were chaul­ style. moogra oil therapy, and, much later, sul- He will be remembered as a staunch fi ghter for his own views. H e believed in them implicitly, for 1'hey were the r esult of " Report of the Leonard \ Vood Memori al Confer· long and deep refl eotion. In spite of all this, ence on Leprosy. Held in Manila, Philippine l s· lands. J anuary 9 1023, 193 1. Philippine .J. Sci . 44 as a review of his correspondence shows, he (193 1) 449·480. was always receptive to the opinions of 352 Til tel'll (f I tOllal j Olll'llal of L eprosy 1965 others, cvcn tho ll gh reserving the ri ght to ogy o[ the blastolll yceti c illfections. New disscnt. As in the case of so many mcn, hi s Orleans t, led. & Surg. J. 68 ( I ~) 1.'5) 2S7- latcr ycars wel'C cloudcd hy phys ical frail­ 298. ity. H c was unable to finish much rescarch S. \VADE, 11. \V. A cO lllp;trison o[ Lh e natll­ that was still in course at thc time of his ral hemolyti c activity or fresh human sera death. His declining health had becn ac­ against guinea-pig and sheep erythro­ cytes. Med. Res. 34 (1916) 113-119. centuated by the unhappy circumstances of J. internment in C ulion in World War II. H e 9. WADE, H. W. Carbohydrate fermenta­ tion by bacillus pestis, comparin g certain retired from the scene quie tl y, to be Am eri can and Oriental strains with anal­ rcmembered for wlnt hc had accomplishcd ys is of discrepancies with Hiss's serum during his many years of aotive investiga­ water, litmus agar, and bouillon. Philip­ tion. Added to that had b een an cqually pine J. Sci. 11 (1916) 159. long participation in the cooperative' ad­ 10. WADE, n. W. Cultiva tion of pathogenic ministrativc activities necessary for scicn­ fungus which exhibits botryoid and leu­ tifi c progress in our time. cocyte-like parasitic form s. Philippine J. His eonh'ibutions to leprosy invt'sti gation Sci. 11 (1916) 267-283. and control were rccognized in many hon­ J J. \ VADE , H. W. Note on the portal of ors and testimonials, mos t of which were entry in experim ental chronic pulmonary noted in the INTEI\NAT10NAL JOU I\ NAL OF (systemic) blastomycosis. Philippine J. LEPROSY. IIe was twicc chairman, in 1952 Sci. 13 (1918) 271-274. and in 1959, of thc Expcrt Committee on 12. \ VADE, H . W. A preliminary report on a Lcprosy of th e "Vorld H ealth Organization. case of hemopoietic splenomegaly with marrow sclerosis. Philippine lsI. Med. Wadc is survived by his wife, sti ll li vin g J. Assoc. 1 (1921) 14.3-149. in Culion, and a sister, ~[is s Marjorie Wade I :3. "VADE , ' H. "V. Preliminary notes on re­ of Millis, Massachusetts, U.S.A. -E. R sults of lepros y treatment at Culion Lep­ LONG er Colony. J. Philippine. Is1. Med. Assoc. 3 (1923) 236-241. J 4. WADE , H. W. Notes on the trip of the BIBLIOGRAPHY Philippine delegati on to the Fifth Con­ Papers by H. W. Wade gress of the Far Eastern Association of and Associates Tropical Medicine with special reference to leprosy. .T. Philippine lsI. t, led. Assoc. 1. WADE, H. W . Primary Hodgkin's disease 4 (1924) 16-24. of the spleen (Dorothy Reed type) . J. J 5. WADE, H. W. Leprosy work in the Phil­ Meel. Res. 29 (191.3) 209-216. ippines. Trans. Vth Biennial Con gr. Far 2. WADE, H. W. On the origin of the blood Eastern Association of Tropical Medicine, cells and the differentiation of the leuco­ Singapore, 192.3; London, 1924, pp. 363- cyte. New Orleans Meel. & Surg. J. 67 .377. (1914) 327-332. .3. WADE , H. W. On the bacteriology and Hi. WADE, H. W. Compl aints of patients un­ pathology of bubonic plague. New Or­ der antileprosy treatment. II. Compari­ son of plain chaulmoogra ethyl esters and leans Med. & Surg. J. 67 (1914) 419- 426. two iodized preparations. Philippine J. 4. WADE, H. \V. Bacteremi a due to bacillus Sci. 25 (1924) 693--710. diptheriae. J. Infect. Dis. 16 (1915) J 7. \ VADE, H. W. Complaints of patients 292-302. under antileprosy treatm ent. III. Com­ 5. \VADE , H. \·V. A specim en of congenital parison of creosoted and non-creosoted inguinal implan tation of the vermiform chaulmoogra eth yl ester preparations. appendix. J. Am eri can Med. Assoc. 64 Philippine J. Sci. 26 (1925) 21-45. (1915) 819-820. 18. WADE, H. W. On certain pathological 6. \VADE, H. YV. Spontancous rupture of aspects of leprosy. Indian Med. Rec. the kidneys, with secondary perirenal 44 (1926) 258-263. hemorrhage, in acute toxic nephritis. J 9. WADE, II. W. Studies on serology of J. Med. Res. 32 (1915) 419-431. leprosy. n. Nitric acid preparation 7. WADE, H. W. Symposium on blastomy­ (Bruck, modified). Philippine J. Sci. 30 cosis . . 1. On the bacteriology and pathol- (1926) 59-67. 36, 3 Obilllmies :35:3

20. \VADE I-1 . \\'. Pre limillarv notes on sero­ 36. \ VADE, H. \ V. Tube rculoid changes in logicni findings in l e pro~y . W ith spedal leprosy. III. The pathology of nerve ab­ reference to certain n:l1l-specific d e ter­ scess. Internat. J. L eprosy 2 (] 934) 293- m in a ti ons. T rans. VIth Con gr. Far East­ 300. e rn Association of Tropical :\Iedicine, :37. WADE, H. Woo A case of neuritis of the Tokyo, Ja pan, J92.5; Tokyo, ]926, Vol. lateral femoral nerve. Internal. J. Lep­ 2, pp. 637-649. rosy 2 ( 19.34) 4.51 .. 454. 21. \ VADE, H . \ V. l\'otes O il the patholog\· of .3R. \ VADE, H . Woo T he bacte riological exami­ le prosy. J. Phili ppine lsI. ~I e d. Ass ~ )c. nation in l epros~ ' . L e prosv Hev. 6 ( ] 9.3.5 ) 6 ( ] 926) :17-42. .54 .. 60. 22. \ VADE, II. \ V. A simple hood for lIse .39. \ VADE:, II. \V. Tube rculoid changes in w ith binocular microscope. J. Lab . & leprosy. I\'. Classification 01' tuberculoid C lin. ~ l e( 1. 13 (1927) R3-R6. leprosy. J nte rnat. J. Leprosy 3 ( J 9.3.5 ) \ VADE, H . \ V. Hem a rks on comparison of 121-136. leprosy and tuberculosis \Ionth. Bull. 4(). \ VADE , I-1. \\'. Hegional variations of lep­ Philippine I-Tlth. Se rvo. 7 ( J 927) 5:3-.56. rosy w ith special re ference to tuberculoid 24. WADE, IT. \\'. Studies in serology of le prosy in India. I ndian I\[ed. Gaz. 71 leprosy; nitric-acid precipitntion ( Bruck, (19.36) 65:3-659; aT. 0 Leprosy in India modified) . ~ I onth. lIull. Philippine ITIth . 9 (19.37) .3- 13). Servo. 7 (1927 ) 1-.'5 . 41. \ VADE , II. \V. T he skin lesions of neural 2.5. \ VADE, II. \ V. Postll1ortem findings in le prosy. 1. General introduction. ]nternat. acute jelly-fish poisoning with sudden J. L eprosy 4 (1936) 409-4 .3 0. death in stntus lymphaticll s. Ameri can J. ,12. WADE, H. W. Problems of all ergy in lep .. Trop. IVIed. 8 ( 1928) 2:33-24 l. rosy. FestschriFrt Bernard Nocht. B am .. 26. \ VADE, H . \ V. The vnriable partial solu­ burg, Augustin, 1937, pp. 652-655. bility of basic fuch si n in nlcohol. J. Lah. 4.1. \ VADE , IT . \ V. A proposed revision of the & C lin. ~ r e d. 13 (1928) 10.'52-10.56. Conference classincation 27. WADE, H. \ V. The d evelopment of the ~ I e morial oJ leprosy. American Trop. ~ led. 17 m odern a ntileprosy treatme nt and of the J. ( 1937) 773 .. 80l. d awn of hope for the lepe rs. ~ lanil a D ail y Bull., Februa ry J, ] 92R. 44. VVADE, H. \V. A report o n the Cairo Lep­ 28. WADE , H . W oo L e prosy. \Iil. Smg. 64 rosy Congress. National Hesearch Coun­ (1929) 8 ] -90. cil of the Philippines, Bull. No. I R, 1938, 29. VVADE, H . \ V. Evolution of the campaign pp. 22-41. in the Philippille Islands. Leprosy Rev. ] 4.5. \VADE , no. \V. The [nte rn:ltional Journal ( 1930) 3-7. of Leprosy. Heport o f the Editor for the 30. . VVADE, H. \ V. D emonstration o f South years 1932-1937. InternaL J. Leprosy 6 African tuberculoid leprosy. Proc. Hoy. (1938) 529-576. Soc. :\1ed. 25 (1932) 1023-1029. 46. ' VADE, H. \ V. The lepromin reaction in 31. \ VADE, H. \ V. Comments on a criticism normal dogs; preliminary report. Inte rnal. of the L eonard \ Vood \1emorial Confer­ J. Leprosy 9 ( ] 94 1) .39-56. ence report. L e prosy in India 4 (19.32) 47. WADE, H. W. High lights of wartime 56-60. Culion. The Star (Carville) 6 ( 1946) 32. \ VADE, H. \ V. T he present problem and ] -.3. organizntio n of leprosy research . C hinese 48. \ VADE , II. \ 11,1. R e ports on leprosy cam- M ed. J. 47 ( 1933) 233-247. p aign. Tat'!. Trib. Stars and Stripes 55 33. VVADE, H. VV. Tuberculoid leprosy nml ( 1947) 8. its classification. T rans. IXth Con gr. Far 49. WADE, H . W. L eprosy. Tn D erma tology Eastern Association Tropical M edicine, in General Practice. S. S. G reenbaum. Nanking, 19.34, Vol. 1, pp. 685-697. Philadelphia, F. A. Dav is Co., ] 947, 889 34. WADE , IT . \V. Tuberculo id ch anges in pp. leprosy. T. The pathology of tube rculoid :'iO. WADE , H . W oo The e ffects of staining leprosy in SO llth Africa. I nternnt. J. technique on the morphology of the lep­ Leprosy 2 (ml.. j) 7 ...1R. rosy hacilllls in smears. Preliminary rc­ 3.'5. \ VADE, 11. \ V. Tuberculoid ch anges ill port. ~lem. V th Congr. Illt ernac. Lepra. leprosy. 11. Lcpra reaction in tubcrculoid 1r avana, 1948; ITa vana, ] 949, pp ..5 12- leprosy. Internat. J. L e prosy 2 ( 1934 ) .516. (Abstract in I nternat. J. Leprosy 16 279-292, . ( 1948) 297). 354 International jomnal of Leprosy 1968

51. WADE, H. W. Sensitizati on of dogs by 65. WADE, H. W. The nature of the erythe­ the lepromin reaction; preliminary report. ma nodosum type of reaction lesions in Mem. Vth ·Congl'. Internac. Lepra, Ha· lepromatous leprosy, with special refer­ vana, 1948; H avana, 1949, pp. 617-620. ence to effects of repeated reactions. (Abstract in Internat. J. Leprosy 16 Mem. Vlth Internac. Congl'. Lepro!., (1948) 301-302). Madrid, 1953; Madrid, 1954, pp. 725- 52. WADE, H. W. Hazard of laboratory in ­ 729. fection with leprosy. J. American Med. 66. WADE, H. W. Modern treatm ent of lep­ Assoc. 140 (1949) 1113. (Correspond­ rosy. British Mee!. J. 2 ( 1955) 491-492. ence) . (Correspondence ) 53. WADE, H . W. Reactions to tuberculin s 67. WADE, H. VV. A note on the less familiar in leprosy. A review. Intern at. J. Leprosy forms of leprosy. Leprosy in India 28 18 (1950) 373-388. (1956) 41-49. 54. WADE, H . W. The reacti ons to lepromin 68. WADE, H. W . A modification of the Fite in man. I. A suggestion of possible de­ formaldehyde (Fite I) method for stain­ sensitization of the early reaction. In­ ing acid-fast bacill i in paraffin section. tern at. J. Leprosy 18 (1950) 487-492. Stain Techno!. 32 (1957) 287-292. 55. WADE, H . W . The persistent problem of 69. \V ADE, H. W. Nomenclature of skin-test latent leprosy. Rev. Argentina Derma­ antigens. Trans VlIth Internat. Congl'. tosif. 3S (1951 ) 105-111. Lepro!. , Tokyo, 1958; Tokyo, 1959, pp. 167-168. (Abstract in Internat. J. Lep­ 56. WADE, H . W. Skin scrapings in leprosy. rosy 26 (1958) 425-426) J. Ameri can Med. Assoc. 149 (1952) 70. WADE, H. W. The first phase of border­ 1595. (Correspondence) lin e transformation. The so-called "re­ 57. WADE, H. W. The Leonard Wood Me­ lapsed tuberculoid" condition. Internat. morial Working Clinical Conference held J. Leprosy 28 (1960) 105-112. in Japan, Sept. 15-27, 1952. Internat. 71. WADE, H. W . Lepromin vs. purified J. Leprosy 20 (1952) 385-389. bacill us suspension. I. Preparation of a 58. WADE, H. W. The classification of lep­ purified bacill us suspension (with a note rosy. A proposed synthesis based pri­ on Nile-blue staining of smears). Internat. maril y on the Rio de Janeiro-Havana sys­ J. Leprosy 30 (1962) 19-26. tem. Intern at. J. Leprosy 20 (1952) 72. WADE, H. W. Zenker vs form alin fixation 429-462. for the histopathology of leprosy tissues 59. WADE, H. W. Notes on the carbowax and other desirable features of technique. method of making tissue sections. Stain Internat. J. Leprosy 30 (1962) 478-488. Techno!. 27 (1952) 71-79. ( Technical note) 60. WADE, H. W. Demonstration of acid-fast 73. WADE, H. W . The histoid variety of bacilli in tissue sections. American J. lepromatous leprosy. Internat. J. Leprosy Path. 28 (1952) 157-170. 31 (1963) 129-142. 74. WADE, H. W. and AVELLA NA BASA , 61. WADE, H. W. Discussion on the control J. The Culion Leper Colony. American of leprosy. J. Philippine Pub!. Hlth. J. Trop. Med. 3 (1923) 395-411. Assoc. 1 (1952) 15-18. 75. WADE, H. W. and Du PRE LE Roux, J. J. 62. WADE , H. W. Iodine in leprosy. Ameri­ A leprosy case progress chart. Internat. can Rev. Tuberc. 68 (1953) 295-296. J. Leprosy 3 (1935) 33-42. (C orrespondence ) 76. WADE, H. W. and FRASER, N. D. The 63. WADE, H. W. The histopathology of the skin lesions of neural leprosy. III. Ob­ lesions of erythema nodos um leprosum. servations in China. Internat. J. Leprosy Paper presented at the Vlth Internac. S (1937) 285-308. Congl'. Lepro!. , Madrid, October 1953. 77. WADE, H. W. and LARA , C. B. A plea (Abstract in Internat. J. Leprosy 21 for the early recognition of leprosy, with (1953) 613-614.) notes on diagnosis and methods. J. Phil­ 64. VV ADE , H. vV. The influence of cortisone ippine lsI. Med. Assoc. 4 (1924) 132- and hyd rocortisone on the lepromin re­ 140. action. Mem. Vlth Internac. Congl'. 78. WADE, IT. W. and LAHA, C. B. Studies Lepro!. , ~'fadrid, 1953; Madrid 1954, pp. on negative lepers. III. The problem of 418-423. (Abstract in Internal. J. Lep­ relapses. J. Philippine Is!. Med. Assoc. l'osY '21 (1953) 582-583.) 7 (1927) 115-122. 36,3 Obituaries 355

79. WADE, H. VV. and LAllA , C. B. The value 92. VVALlE , H. "V., DE SII\I ON, D . S. and F EH­ of present methods of treating leprosy. NANDO, A. C. The skin lesions of neural Proc. Roy. Soc. Med. (Section on Trop. leprosy. V. Observations in Ceylon. In­ Dis., etc.) 20 (1927) 136-142. Also ternal. .T. Leprosy 6 (1938) 199-222. Lancet 1 (1927) 597-599. 9:3 . WADE, H. W., LAllA, C. B. and NICOLAS , 80. WADE, H. vV. and LEDOWSKY, V. The C. Complaints of patients under anti­ leprosy epidemic at Nauru; a review leprosy treatment. I. Nature and fre­ with data on the status since 1937. [n­ quency it) cases receiving chaulmoogra ternat. ] . Leprosy 20 (1952) 1-30. ethyl ester preparations. Philippine J. 8!. WADE , H. W. and LOWE, J. The type­ Science 2S (1924) distribution of patients a t the Purulia 94. WADE, 1-1. W ., RODIH GUEZ , J. N. and Leper Colony. Leprosy in India 9 (1937) TOLENTINO, J. G. The course of open 39-40. cases of tuberculoid leprosy at the Cebll 82. WADE, H. vV. and MANALANC, C. Fun­ leprosarium. Internat. J. Leprosy 7 gous development growth forms of bacil­ (1939) 473-494. lus influenzae. A preliminary note. J. 95. WADE, H. vV ., GUINTO, R. S., LEIKEH, Expel'. Med. S1 (1920) 95-]0.3. D. L ., INNES, J. R. and KooIJ, R. Lep­ 83. WADE, H. W. and PEHRIN, S. R. A case romin vs purified bacillus suspension. IT. of advanced borderline leprosy. Reevalu­ Comparative tests with a purified bacillus ation of a case originall y reported as lep­ suspension. Internat. J. Leprosy 30 romatous. Internal. J. Leprosy 29 (1961) ( 1962) 27-47. 460-472. 98. F ITE, G. L. and WADE , H. W. The con­ 84. WADE, II. W . and PINEDA, E. V. Ob­ tribution of Neisser to the establishment servation of tuberculoid skin lesions of of the Hansen bacillus as the etiologic leprosy in the Philippines. Trans. VI [ agent of leprosy. Internat.]. Leprosy 23 Far Eastern Association of Tropical Medi­ (1955) 418-428. cine, India, 1927; Calcutta, 2 (1928) 97. GAHROD, J. and WADE, H. W . Results 383-389. of repeated injections of lepromin in 85. WADE, H. W. and RODHTGUEZ , J. N. A tuberculoid cases. Internat. J. Leprosy description of leprosy; its etiology, pa­ 29 (1961) 149-156. thology, diagnosis and treatment. Manil a, 98. GU INTO, R. S. and WADE , H. W. Results Bureau of Printing, 1927, 9.3 pp. of tests with serial dilutions of iepromin 86. WADE, H. W. and RODR IGUEZ, T. N. Bor­ in separate groups of nonnal young chil­ derline tuberculoid leprosy. II~ternat. J. dren. ' '''ith a comparison of two leprn­ Leprosy 8 (1940) 307-3.32. mins and the Dharmendra anti{!en. In ­ 87. WADE, H. W . and RODHIGUFZ , J. N. D e­ ternat. J. Leprosy 26 (1958) 328-345. velopment of major tuberculoid leprosy. 99. PINEDA , E. V. and WADE , H . W. The A report of cases. Internat. .T . Leprosy 7 public health value of the Kahn precipi­ ( 1939) 327-340. tation test with special reference to yaws. 88. WADE, H. W. and ROI' H1GUEZ, N. The J. J. Philippine l sI. Med. Assoc. 6 ( 1925) skin lesions of neural leprosy. n. Ob­ 183-187. servations in Cebu. Internal. J. Leprosy 5 ( 1937) 1-30. 100. HODHlCUEZ,.T. N . and WADE, H. W. Bull­ OllS tuberculoid leprosy. Report of a case, 89. WADE, H. W. and SOLIS, F. Studies on with a discussion of Iazarine leprosy. In­ negative lepers. II. The importance of nasal lesions. J. Philippine l sI. Mell. ternal. J. Leprosy 8 (1940) 333-344. Assoc. 7 (1927) 111-115. ] 01. RODHIGUEZ , J. N., WADE , H. W . and 90. WADE, H. W. and STAHING, H. L. A PLANTILLA, F. C. Conversion of simple study of the early cases of bubonic macular neural leprosy to the lepro­ plague in New Orleans. New Orleans matous type. A report of three cases. Med. & SlIg. ]. (1914) 95-10.'5. Internat. J. Leprosy 7 (1939) 463-472. 91. VVADE , H . W ., COCIIHANE, n. r.. :I II fl 102. SOLIS, F . and \VADE, H. W. Bacterio­ RAJ, ~ 1. P . The skin lesions of nemal logical findings in children of lepers, with leprosy. IV. Observations in Madras. special reference to nasal lesions. J. Phil­ South India. Internat. J. Leprosv 5 ippine lsI. Med. Assoc. S (1925 ) 365- ( 1937) 437-462. . 369.