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ISBN I 869835 53 O Ptintcd by Abzrw Ptindng 6.Lunid üOAüD OF GOVERNORS The Wellcome Trust Annuai Record I Ombm 1994-30Spmkr 1995 CONTENTS GENBULINF0MIIK)N Bod ofGavernon ..................... .................. -3 Ditmois Rrpm.... .................. Finuid RNim ....................................................................... IO Suppan for MddRüeurh ............................... ......."..-.".. I2 REmm NcuroaKna Puid ....." ...-.. ...................... 1nrtm.tionnt lntcra Ccnaicrln-r Gm Suppn êthcHmtyofMdMc ..................................... -. 47 W&mc Imtinirc foc rhc HtmyofMcdiciilc ._........"."..-...... 53 lh W&mc Cuim For MddSa- ......-""".-..I.. .... --56 Pmjm Gnno ........................ Wùimmc Pmgnmmc Gnn5 .. ........................................ I33 Inr«n.tionrlPmgMlmr ..... SuppoanfordicHiirniyoCM Kq.wrd lnda ....................... 170 Indo of Uni- uurinila .... "..... 194 Indaof Pur0n.l Nmi ......." .._..........-- -......-.... I97 5 D inE c T O I* I n E PO n T DIRECTOR'S I(itOlT 6 7 MANAGEMLNT STAFF OP THE TRUST a 9 FININCI~L REVIEW FINANCIAL REVIEW Net Auaa h -1 10 II SUIIOIT FOI MEDICAL RESEARCH IW 10 60 IO 10 O l9PIN2 :- =.Ur.- (1110 700 690 SO0 4110 3110 ZW IO0 13 NEUIOSCIENCES PANEL NEUROSCIENCES ?ANIL is I4 NEUIOSCIENCIS PANEL 17 16 INFECTION AND INNUNITY PANEL INIECTION AND IINUNITI CAII~L 19 MOLECULAR AND CELL PANEL HOLECULAI AND CELL PANEL 21 P P SOLE CUL AI AND CLLL QANLL PHVSIOLOGY AND PHAIMACOLOGY PANEL PHYSIOLOGY AND rn~mu~coLoar AUE EL 24 CIREER DEVCLO~~KNTCROUP CAREER OEVELOllENT GROU? 27 c CAREER DEVELOCIENT GR OU^ CARIER DEVELOCIINT CROUP 29 TRO~ICALMEDICINE INTEREST GROUP TROIIC~L MCDICIHL INTE~CSTCROUI 30 31 TROPICAL ~EDICINEINTEREIT CROUI 32 VETERINARY MEDICINE INTLRCST aIOUP 3.5 34 INTERNATIONAL INTE~ESTanour INTERNATIONAL INTLILST anour 36 37 INTERNLTIONLL INTEREST nioup 38 39 GENETICS INTEREST GROUP 40 EQUIPMENT WORKING PARTI EQUIPILNT WORUING PA~TY 43 i 42 POPULATION STUDIES PANEL 44 45 ~O~ULATIONSTUDIES PANEL SUrrOllT 10. TNE HISTORV OF ~CDI~INI! 46 47 SUPPO~TFOI THE HISTOIV SUP,ORT FOR 7HB HISl.OIV Of f4EDICINE Of IODICINE 49 SUPPORT FOR THE HIS TOR^ SUPPORT POR THE HISTORY OF HEO1CINE OF HEDICINE 50 51 SUIPO~T FOI THE HISTOIY WELLCOME INSTITUTE fOI TUC OF MEDICINE HISTORY OF MEDICINE 52 53 ,- WELLCOME IYSTlTUTE FOR THE WELLCOME INSTITUTE FOR TH€ HiSTORY OF MEDICINE HISTORY OF MEDICINE 54 55 THE WELLCOME CENTRE FOI THE WELLCOME CENTRE FOR MEDICAL SCIENCE M(tDICA1 SCIINCE Thii is in ovcMm of the WeUmm Centre's imviriu for 199419% hinhcrdct.il<u. pmvidd in thcpubücrtion Thr Wdhme Cmmfir MdcdStimn R.)on 1594195, 56 57 THE WELLCO~ECENTRE fan THE WELLCO~ECENTRE fou MEOlEAL SCIENCE nzDic~LSCIENCL 59 58 PERSONAL SUP~ORT PERSONAL SUPPORT PERSONAL SUP~ORT STUOENTSHIPS AND SCHOLARSHIPS STUDENTSHIPS ANO SSHQLIRSHtPS PER~ONALSUPPORT PERSONAL IVP~ORT ITUDENTSHI~S AND SCHOLARIHIPS STUDENTSHIPS AND SCHOLARCMI~C Ms c L Overend under Pmferror R D Burpync Fnii.~PhD audmohip pmgnmmr in di& and maiduphysidogy lM427UU95lZi MI K Turner under Professor R D Burgoyne Farr-ymz PhD rtudm<ihipptwmmr inc.llulv and moiduphpidogy (04427I~95iZ) MI A] Smhh under Dr i D Fonyths London: Chvtng Cmu and Westminster inhibimysynipric r-bion in therupmoi Pkdlcai Schwl mmpler (0433zWPm) DrpumicntofAiummr Miss S-ATurnerunderDr DIWatt An invaigarion into the dpofhimiti0n.l impmvcmmr in mdimowemwclcfibrav~raLlultofimplÿrtlrionofmourc and human &al fibmblvu 1044546W95IzJ ikpmmrnt of HumAsammy d Ou Bidw MI O C lalle Lpuemunder DI A W M Simpson Dctcminrtion ofthc molduidcntiiyafthc diannd mpnrible far thc G" rdcurdnrd mmt (CRAC) (0445162795IZ) 65 t P~RSONIL SUPPORT PERSONAL SUPPORT STUD~NTI~IPSAND SCHOLARSHIPS STUDENTS~IPSAND SCHOLARSYI~S Mr J R Tpm under Dr C J Sdrllng hein mrgcMgto rhc uidoplrmic miculum in YLy' (04457m9W Dcpumrnt ofP.lchology Mt 5 J Quinmn under Dr H L Wagner and Dr 5 G Gowen 67 ~I~SONALSUPIOIT rInso~Ii~SUPIOIT STUDENTSH1CS AND SCHOLAISHIPI STUDENTSHI?S AND SCHOLAISHIPI Readlng: Univenly of Reading SchoolofAnirmildMiriobLISdsnm Mr D J Balle), undcr ProfurorJ W Almond lntncdlulu deminuits ofpimmaviw rmpirm (04457.wZ951V 69 PERSONAL SUPPORT STUDENTSHI?S AND SCHOLARSHIPS Dundee: Unlvenlty of Dundee DcpMmmt of Bi&mid M&&e MI R L CUR under Pmferra B Burchdl Wlacim ofrcnobioiicglucvmnidcc.crction fmm humui Cclh (W4lWZ99.Z) Biomcdid lbcamh Cma Mr D C Gallmy under Dr L I Mclelizn WIaim ofapmion ofu-giuumylMyicyrrrincrynrhcruc rubuniu by dimid uici odd.Ovc tima (044440ZJ9z) MirrTOConnervnder DrJD Hayer Idenrificriion ofnovel indudblcddri.hm dumwr (PQR Iand PQR 2) invoid in rr<i'~am &c &nyl- mndning compound< f0444WZ99ZJ 70 71 rcI s O NAL su c c O IT fIL~owsnics Dundee Univeniy ofDundee rwputmrntofdiiydrhfiiw Dr A A Oliou under Prnfuror M J Rrnnie The hmmpcity of ncumd 4ium diuinck: ui ~Immphyriologhlnudy uing moi.culu bioi0gir.l uid irmnitiiutian icdiniqus (036lW92lA) DrputmnitofMedicinc London: Birkbeck College London Dr C H Manhew under Dr V K K Chmer~ce ~~utrn~~ofriydioiaw Produnion ofr moue model far thymid homonc raistÿicc Dr L A Nickels under Dr D Homrd hy hamogoiow ,.combination (0447%vm5IZ) Scmrniic mm in rpkm word pmdunion: &ng and dmlaping 1i conn.crionkt modd wing aphuic nlming em- Edinburgh: Univenlty of Edinburph (0428441.V94lZ) Dcpuunenr ofM+cine Dr R hnedibronunder DI J R SecW Manchester. University of Manchester Inrtihita The irgulrtion ofplvcnd II Bhydmryrtrmid ofScience and Technology diydmgrntrc, dpiarccror of the fcnl rnvimnmnit kpvlmrnt of Biarh.mLq and Applid buppiunm) (04213SfZ94W Mol& Biiiagy Dr SI Hubbard under Rofturw R J +on London: ChsrinE Cmrr and Wertmlnrtsr Smmdprinripb af pmicin moldurrcagniiion Medid School (0447571B95iZJ AcrdcmicUiUt ofNdma Dr M Huuln undsr Pmfesor C Kennard oxford: Univeniy of Oxford %sud inamniion following rrmkc (043397~9SZ) &paltmmt ofhlagy Dr M httuon under Dr A kcelnik London: Inrtihite of Child Health Nninl and pythdogiol m.rhtRvmr oiiniormrtion Molrmlnr Immutlology Unit pmcuing in thcfongingiuiling (04SZ43Z9slZJ DI D Goldblru under Professor M W Turner Pmnting otitk mrdiz: har-Momk rnmddiinrrnnioni mdthcpmsprm foiuioui.rm.mbmcpmti"-"~ (M2~IV ülmingham: Univedity of Birmingham Londai: St My's Hospital Medical School Dlpumimt of Rhcumimiolog. Dcpa~tmrntofMdcii>c DrR1Moouunde~PmfcwrPAb.o" Dr D R O'Donnell under Dr P J M Openrhrw and Pmf-rJ L Swmlnger kimion ofRSvùw-mu<mribycytMoi* ThcfunNanal aimnœofMHCclu. II innmcn in TJymphocyra (MZM4- autoimmunedi- (04415UZ951ZJ 72 PERSONAL SUPPORT PEISONAL IUIIOll FELLOWSHIPS FELLOWSHI.. London: University College London London: Instihite of Ophthaimology Deputment ofMedicine Department of Uinid Ophtbnlmology Dr AJThrasher under Prokror R J Levinrky Mr J A Pdtrenon wder Pmferrw S L Ughviun and Pmferror A W Segai and PioferrorA M Siliho Dmlopmrnt ofeflicirni mçlhoL far gcnc IMS,~~ Stimvlu binding-. nrupcnpaivcofrmLiyopia? oprcuion in rhmnic gnnulomrmu dime (MsWz95u) (044783fmSfZ) Dcputmmt of Molecular P*thology London: InstituteofPnlchirtlychlatty Dr L R Weddohum under Pmksror P Woo Dcp-ent of Neurology TheT-cd qpcnoirc in human diwu. moidu Dr LA Henry under Dr G H Gudjonrton chmcioiution ofihcT.dI raponw in juvenile rhmnic Eymimarmcmoiyinrhildrm with lainingdiflidtia anhriiis (wigid rdplu addition4 apuua) (0428mfmiz) (044lssfz95/A) Oxford: Universly of OxfDrd NuRicld Lbontory ofOphth.lmology Dr J C Rndit under Dr J M Tihyand Pmferror A] Bmn Brighton: Unlverrlty ofSusrex Thcioicofmumsin dcrcimining r~uv'ucadry(ormsion) School of Biolo+l SOmcer (0424E4iZ941lU Dr N H Smith under Pioferror B G Spart cui 2 Aid phylogmyhe mnnructdfor hactterir thZr arc nrrunlly tnnrformbi.! A moidar phylogencricm4pk of rhcgmu Ndud (044~WIlZ75iz) Bristol! Unlveniy ofüri5toi Dep-~>t of Biocb.mimy Leeds: Unlverslyof Leeds Dr N T Redpath under Pmfcsor C G Pmud Cambridge: Univerriy of Cambridge Deputmeni ofGennics A study of malmludoningmd mgulitionofclongrtion Depvtment af hihology Dr C Walron under Dr R K Butlin famar-2 kinue (atmrion) (03E7lSiZ931A) Or D Trump undw Dr J R W Yates Phyiogcny of thcdim~mmpiaofrlnopklmnd gcnc and Rofeuoi M A Feguton-Smith achrngr bcnven sympniicA dims Aand C popuirdonr Cambridge: Unlverrly of CmMdge Thcmolrcuhr pathdog. ofX4inkcd minarchisis wing DNAquencc and mimurdlitc analyst WeUmmdCRC InnituteofCamri (04S37Sfz9Siz) (043944E77SIZ) md Dmlapmsntnl Blology Dr G A Mathews under Dr C UmndiSonrQnt Leicester: Unlverrly of Leicester Thc mk offibtonmint in puiphenl n-yt VIM D~putmentof BiocbemUvy mgenenrion (mMion) (035S6ZWWA) Dr 5 L Chm under DI i C Epemn Mcchmismt ofhomonily rcguliinl dicrnativc splicing of thc imulin-lihgmulh factor4 (iGF.1) enc (04540IlZ95~ 74 75 PEISONAL SUPPORT PERSONAL SUICOIIT FELLOWSHIPS FELLOWSHI~S 76 77 r ! PERSONAL SYPPOR7 FeL~owsn~rs 78 79 - PERSONAL SUPPORT PE~SONALSUIIO~T FELLOWSHIPS FELLOWSHIPS London: Birkbeck College London Diputmelit c.fCr+Iopphy Dr H R Sribii For cryo-EM and imappramring mdia on moldulu chqmonu 2nd rhodopsin (04SOS5lZ95RR) London: Royal Free HospitalSchwi of Medicine Drpmciit of Physiology Dr A M Thomson Phyriology and morphology of single tynrptis wnnmiant bc-n nmmnu radcdintmddululy in dcu of nt "-"a (CItCNiD") , (036094lZ92/A) London: Univerrity College London ~eputm~tnrhyioiw DrS E Mors Mmhrnbm and rrguiaion ofurnoin VI fun~ion f0447aImsE) Nottlngham: Univenly of Nofflngham Deputment ofLifcSdensa Dr D I Prhchard under Profasor G C K Robem Thc ÿalation and idmuiftotion ofthcalhgn(r) ofrhc human hookworn Nmimrammninu f04S03llmslZ) Oxfold: Oxford Bmoker Univenly S&ml ofBioIogld and Molenlnr Sdcncc< Dr M üpe Forthcdmiopmmt ofrhcMFdid Scimcct Vidco-Mh of