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2016 Science Research Conference (SRC) Directory

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Dear Prospective Attendee,

On behalf of the FASEB Science Research Conferences program, we would like to invite you to participate in our 2016 conference series.

FASEB SRCs are held annually at several locations worldwide, with an average of 100 to 150 attendees per conference. These intimate settings allow attendees to have in-depth discussions about the science presented, its future, and the contributions they hope to make in their respective fields. Each meeting spans five days, allowing time for established scientists to share their work and for trainees to participate in Meet-the-Expert Sessions. Participants also have the opportunity to present their research either as short-talks or during poster sessions. In addition, the SRCs provide a welcoming environment for scientific discourse, collaboration, and opportunities to mentor the next generation of researchers. Please join more than 4,000 researchers who will be participating in one or more of the 36 conferences this year. We look forward to seeing you!

Guy Fogleman, PhD Executive Director, FASEB

SRC Conferences for 2016

Biological Methylation: Fundamental KLF and Sp Transcription Factors in Renal Hemodynamics and Mechanisms in Health and Disease Disease and Regenerative Medicine Cardiovascular Function in Calcium and Cell Function Lipid Droplets: Dynamic Organelles in Health and Disease Cell Signaling in Cancer: From Metabolism and Beyond Retinal Neurobiology and Visual Mechanisms to Therapy Liver Biology: Fundamental Mechanisms Processing Consortium on Orthodontic Advances in and Translational Applications Skeletal Muscle Satellite Cells and Science & Technology (COAST) Matricellular Proteins in Development, Regeneration Dynamic DNA Structures in Biology Health, and Disease Smooth Muscle FASEB 3rd International Conference on Microbial Glycobiology The Biology of Calpains in Health and Retinoids Molecular Biophysics of Membranes Disease Folic Acid, Vitamin B12, and One-Carbon Neural Mechanisms in Cardiovascular The Lung Epithelium in Health & Disease Metabolism Regulation: Novel Research and Disease Trace Elements in Biology and Medicine Functional Disulfide Bonds in Health Treatment Strategies Translational Neuroimmunology: From and Disease Phospholipid Signaling in Cancer, Mechanisms to Therapeutics Genome Engineering: Cutting-Edge Neurodegeneration, and Cardiovascular Ubiquitin and Cellular Regulation Disease Research and Applications Virus Structure and Assembly GTPases in Trafficking, Autophagy and Post-Transcriptional Control of Gene Expression: mRNA Decay Yeast Chromosome Structure, Disease Replication, and Segregation IgE and Allergy, 50 Years & Onward Protein Folding in the Cell Immunological Aspects of Obesity Protein Kinase Signaling Network Regulation Immunoreceptors Protein Phosphatases

2 FASEB Science Research Conferences 2016 Register Today!

FASEB Science Research Community We Strive For A Diverse Pick a Community Conferences (SRCs) are a The SRCs are held annually and are FASEB, as a longtime recipient organization continuing series of small, focused on building communities of of federal funding support from the interest around critical research topics. This intimate interdisciplinary National Institutes of Health/National encourages collaboration and mentoring. Institute of General Medical Sciences (NIH/ conferences that explore new NIGMS) and other federal agencies, has a approaches in research areas strong and well documented commitment Registration Information in helping to inspire and develop a undergoing rapid scientific diverse and inclusive biomedical research advances. Registration Types workforce and community. Single Occupancy: includes a single guest For more than 30 years, the FASEB We invite you to join room for one attendee. Maximizing Access to Research Careers (MARC) program has promoted diversity more than 4,000 fellow Double Occupancy with Another in the biomedical and behavioral sciences, attendees at these exciting Attendee: includes a double occupancy as well as the training and advancement of room shared with another paid attendee. underrepresented students, postdoctoral and engaging conferences fellows, faculty, and scientists. FASEB’s Double Occupancy with Guest: includes exploring and discussing policies and interests in enhancing the a double occupancy room shared with your participation of individuals from groups topics in your field. personal invited guest. Guests receive meals, identified as nationally underrepresented and lodging. Guests may not attend general in the biomedical, clinical, and behavioral sessions or poster sessions. and social sciences are consistent with the Why Attend Offsite Attendee: The offsite registration NIH/NIGMS and other federal agencies ▶▶FASEB offers an all-inclusive registration fee includes meals and meeting fees. If which support FASEB’s sponsored fee, which includes meals, lodging, and you choose off-site registration, you are programs and activities. responsible for securing and paying for your meeting fees. Career-Oriented Workshops lodging, as well as local transportation to ▶▶All SRCs are organized by leading and from the meeting. Some FASEB Science Research investigators in their fields of expertise. Conferences include a biomedical research ▶▶The SRCs spur innovation and the Registration Fees workforce development workshop and/ exchange of knowledge. or a career-oriented workshop for trainees ▶▶Registration fees vary depending upon ▶▶The small size of the conference is (graduate students, postdoctoral fellows) your conference location and registration designed to promote interaction through and early-career investigators. These type. If you register after the early-bird Poster Sessions, Meet-the-Expert Sessions, workshops are designed to help prepare registration deadline, an additional $150 and for some conferences, a career trainees and early-career investigators will be added to the registration fee. development workshop. for a variety of career options in the Fees cannot be prorated or discounted modern biomedical research workforce ▶▶The SRCs offer a wide variety of ▶▶ conference topics in the biomedical field due to contractual arrangements with through broadening their career and skill across the U.S. and around the world. venues. development outside traditional training. They allow opportunities to promote ▶▶Register early to avoid late fees. career/skill development, mentoring, ▶▶Advanced registration is required. On-site networking, and interaction among the registration is not permitted. SRC participants. ▶▶Only attendees who have registered and Meet The Expert Sessions Visit Our submitted a CV may participate in the conference. FASEB SRCs include Meet-The-Expert Website sessions for junior investigators. Junior ▶▶Abstracts are due at the time of investigators’ work will be presented to registration, if interested in presenting a allow opportunities for them to promote poster or short talk. interaction with more senior participants ▶▶Conference registration closes four weeks of the conference. prior to the start of the conference. Need help making the Poster Sessions for Junior case to attend an SRC See page 5 for registration fees. Investigators For the COAST Conference, please see Junior investigators' work will be presented to your boss? additional pricing information on the to allow opportunities for them to promote Visit the Attendee Information page, COAST microsite. interaction with more senior participants. where you can download a letter template.

Registration and Payment If I’ve submitted an abstract, will I with special family care needs (the off-site present a poster? fee includes the conference and all meals What does the registration fee include? Yes. A poster presentation schedule will be listed but enables attendees to book their own The single and double occupancy attendee in the program provided at the conference. accommodations). Both the FASEB and venue registration fees include five nights of lodging websites include information on nearby (Sunday through Thursday, with checkout How do I indicate that I want to give a off-site accommodations that can assist on Friday morning), all meals (five breakfasts, short talk at the conference? attendees with locating licensed child care five lunches, and five dinners), and access When registering select the “short talk” providers and daycare services. The venue to all scientific sessions and posters. The button. Your information will be shared with management will also provide any assistance off‑site registration fee includes all meals (five the conference organizer. The organizer will to attendees regarding child/family care breakfasts, five lunches, and five dinners), and contact you, if you are selected to present issues or concerns. Each attendee is also access to all scientific sessions and posters. your paper. You will also be allowed to present encouraged to contact FASEB with any special your poster during the poster sessions. What forms of payment are accepted? needs that they may have. FASEB only accepts Visa, MasterCard, and American Express. Lodging Cancellation What do single occupancy, double What is the cancellation policy? I cannot stay at the conference for the occupancy, and off-site lodging mean? entire time. Can the registration fee be Cancellations received before the cancellation Single occupancy – one (1) registered prorated? deadline will receive a full refund less a conference attendee to a guest room. No. FASEB is contractually obligated to pay $250.00 cancellation fee. See the cancellation for five nights of lodging (official conference Double occupancy – two (2) registered deadline date for your conference. There will dates only) at each conference regardless of the conference attendees sharing one guest room be no refunds issued if the cancellation form is number of nights an attendee chooses to stay at with two beds. Each attendee pays the double received after the cancellation deadline date. occupancy registration fee. the venue. I cannot attend the conference; can I Off-site – the attendee is responsible for send someone in my place? International Attendees arranging for and paying for their own lodging Substitutions are not allowed. Each attendee How can I get an official letter of arrangements. must register and be approved to attend the invitation to attend the conference? I need to arrive a day before the conference based on their credentials. During the registration process, there is a conference starts and/or stay a day check box option for a letter of invitation. after the conference has concluded. Who to Contact Mark this box, and a letter of invitation will How do I make arrangements for the FASEB SRC Staff be sent to you as part of your confirmation extra night(s)? Robin Crawford, CMP materials once your registration and payment After you receive your lodging confirmation Conference Manager have been processed by the online system. from FASEB, you must contact the venue directly [email protected] to make arrangements for the extra nights Abstracts and Posters of lodging. You are responsible for paying for Kristen Hagy, CMP any additional nights. Please note: in Vermont, Conference Manager Do I have to submit an abstract with my [email protected] registration? additional nights at the dorms are not possible. You must make a reservation at a local hotel. Trina Eacho No. Submitting an abstract is optional unless Research the city of your conference for Conference Coordinator you want to be considered for a poster session additional venue options at www.faseb. [email protected] or short talk. org/src. Pippa O’Shea Can I register now and submit my Conference Assistant abstract later? Child and Family Care [email protected] No, abstracts must be submitted when you Resources Fundraising/Sponsorship register to attend the conference. Are child care and/or family resources Sherri-Gae Scott, Ph.D. Can I register and submit my abstract are available? Grants Proposal Manager [email protected] after the early-bird deadline date? FASEB provides detailed information for each Yes, as long as there is space available at the conference site on the Science Research Mailing Address conference. A late fee of $150.00 will be charged. Conference (SRC) website and also provides FASEB Science Research Conferences What is the latest date to submit an venue information directly to each attendee. 9650 Rockville Pike abstract? Although FASEB does not provide child care Bethesda, MD 20814 services, attendees are welcome to have Abstract deadline for inclusion in the program [email protected] guests (including spouses, children, nannies and consideration for a short talk is the last (301) 634-7010 and babysitters) accompany them to the day to register for the conference. See page 5. conference to provide such care. FASEB offers an alternative off-site registration fee at all conferences, to accommodate those

4 FASEB Science Research Conferences 2016 Important Deadlines & Registration Fees

Deadlines

Early Bird Registration Last Day to Conference Title Conference Dates Deadline Register Biological Methylation: Fundamental Mechanisms in Health and Disease June 19 - 24, 2016 May 5, 2016 May 20, 2016 Calcium and Cell Function June 12-17, 2016 April 28, 2016 May 13, 2016 Cell Signaling in Cancer: From Mechanisms to Therapy June 5-10, 2016 April 21, 2016 May 6, 2016 The Consortium for Orthodontic Advances in Science & Technology (COAST) September 8-11, 2016 July 25, 2016 August 7, 2016 Workshop on “Personalized & Precision Orthodontics” Dynamic DNA Structures in Biology July 10-15, 2016 May 26, 2016 June 10, 2016 FASEB 3rd International Conference on Retinoids June 19 - 24, 2016 May 5, 2016 May 20, 2016

Folic Acid, Vitamin B12, and One-Carbon Metabolism August 7-12, 2016 June 23, 2016 July 8, 2016 Functional Disulfide Bonds in Health and Disease August 14-17, 2016 June 30, 2016 July 13, 2016 Genome Engineering: Cutting-Edge Research and Applications June 5-10, 2016 April 21, 2016 May 6, 2016 GTPases in Trafficking, Autophagy and Disease September 18-23, 2016 August 4, 2016 August 19, 2016

IgE and Allergy, 50 Years & Onward July 24-29, 2016 June 9, 2016 June 24, 2016 Immunological Aspects of Obesity July 31-August 5, 2016 June 16, 2016 July 1, 2016 Immunoreceptors June 12-17, 2016 April 28, 2016 May 13, 2016 KLF and Sp Transcription Factors in Disease and Regenerative Medicine August 7-12, 2016 June 23, 2016 July 8, 2016 Lipid Droplets: Dynamic Organelles in Metabolism and Beyond July 24-29, 2016 June 9, 2016 June 24, 2016 Liver Biology: Fundamental Mechanisms and Translational Applications June 26-July 1, 2016 May 12, 2016 May 27, 2016 Matricellular Proteins in Development, Health, and Disease July 17-22, 2016 June 2, 2016 June 17, 2016 Microbial Glycobiology June 12-17, 2016 April 28, 2016 May 13, 2016

Molecular Biophysics of Membranes July 10-15, 2016 May 26, 2016 June 10, 2016 Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease July 17-22, 2016 June 2, 2016 June 17, 2016 Treatment Strategies Phospholipid Signaling in Cancer, Neurodegeneration and Cardiovascular Disease July 31-August 5, 2016 June 16, 2016 July 1, 2016 Post-Transcriptional Control of Gene Expression: mRNA Decay July 10-15, 2016 May 26, 2016 June 10, 2016 Protein Folding in the Cell July 24-29, 2016 June 9, 2016 June 24, 2016 Protein Kinase Signaling Network Regulation July 17-22, 2016 June 2, 2016 June 17, 2016

Protein Phosphatases July 17-22, 2016 June 2, 2016 June 17, 2016 Renal Hemodynamics and Cardiovascular Function in Health and Disease June 19 - 24, 2016 May 5, 2016 May 19, 2016 Retinal Neurobiology and Visual Processing July 10-15, 2016 May 26, 2016 June 10, 2016 Skeletal Muscle Satellite Cells and Regeneration July 24-29, 2016 June 9, 2016 June 24, 2016 Smooth Muscle July 17-22, 2016 June 2, 2016 June 17, 2016 The Biology of Calpains in Health and Disease July 17-22, 2016 June 2, 2016 June 17, 2016

The Lung Epithelium in Health & Disease July 31-August 5, 2016 June 16, 2016 July 1, 2016 Trace Elements in Biology and Medicine June 5-10, 2016 April 21, 2016 May 6, 2016 Translational Neuroimmunology: From Mechanisms to Therapeutics July 24-29, 2016 June 9, 2016 June 24, 2016 Ubiquitin and Cellular Regulation June 12-17, 2016 April 28, 2016 May 13, 2016 Virus Structure and Assembly July 24-29, 2016 June 9, 2016 June 24, 2016 Yeast Chromosome Structure, Replication, and Segregation July 31-August 5, 2016 June 16, 2016 July 1, 2016 Registration Fees (in USD) Additional Guest Double with Double with Off-site Conference Location Single (3rd guest, ages 10 Attendee Guest Attendee & over) Big Sky, MT, Big Sky Resort $1,725 $1,360 $2,240 $725 $1,000 Keystone, CO, Keystone Lodge & Spa $1,530 $1,300 $2,200 $845 $1,000 West Palm Beach, FL, Marriott West Palm Beach* $1,525 $1,305 $2,280 $930 $1,000 Saxtons River, VT, Vermont Academy $1,155 $995 $1,670 $690 $795 Snowmass Village, CO, Base Village Conference Center $1,485 $1,190 $2,090 $815 $1,000 Steamboat Springs, CO, Steamboat Grand Resort $1,375 $1,185 $2,085 $885 $1,000 Lisbon, Portugal, Marriott Lisbon Hotel $1,720 $1,465 $2,515 $1,005 $1,095 *See special pricing for the Coast Conference on page 7.

Register Now! www.faseb.org/SRC 5 2016 Science Research Conferences Biological Methylation: Fundamental Mechanisms in Health and Disease June 19-24, 2016, Marriott Lisbon Hotel, Lisbon, Portugal

This SRC is focused on the role of methylation dynamics in nuclear and Highlights Important Deadlines cytoplasmic biological processes and how this modification impacts ▶▶Welcome Reception Early Bird: May 5, 2016 development, epigenetic cellular identity, tissue homeostasis, and disease. ▶▶Meet-the-Experts Session Last Day to Register: May 20, It will present studies looking at how this chemical modification impacts ▶▶Short talks selected from 2016 nucleic acid and protein function across model systems and in disease submitted abstracts models. These topics will be complemented with presentations on how ▶▶Poster Sessions dedicated to Transportation & methylation states are established, maintained, interpreted and inter- trainees Lodging converted, along with their functional cellular consequences and how this translates into developmental and disease states. Since methylation has Keynote Speakers Official Conference Lodging: Lisbon Marriott Hotel, Avenida become a major therapeutic target in recent years, there will be a focus on Van Andel Peter Jones, dos Combatentes, Lisboa (Lisbon) the advancements in therapeutics and technologies used to quantitatively Research Institute Portugal monitor this modification in cells and organisms. Genevieve Almouzni, Airport Information: The This meeting will bring together an interdisciplinary group of scientists Institute Curie closest airport is the Lisbon interested in how a small covalent modification can have such profound Portela Airport (LIS), which is 4.3 Conference Organizers miles or 6.9 kilometers from the biological impact. Invited speakers are experts in biological methylation Cheryl Arrowsmith, Lisbon Marriott Hotel. from a variety of perspectives including cell and developmental biology, University of Toronto molecular biology, epigenetics/epigenomics, structural biology and Johnathan R. Whetstine, chemical biology. The conference will optimize interactions among all Ph.D., Harvard Medical School attendees, with several poster sessions and technology workshops. A and Massachusetts General significant number of oral presentations will be chosen from poster Hospital Cancer Center abstracts submitted by trainees and junior faculty. This conference Register will also be an excellent opportunity for scientists less familiar with Now! methylation mediated signaling and epigenetics to learn how this rapidly evolving field could impact their research.

Calcium and Cell Function June 12-17, 2016, Marriott Lisbon Hotel, Lisbon, Portugal

This SRC focuses on calcium channels, signaling pathways, and binding Highlights Important Deadlines proteins in health and disease. Calcium is indispensable for normal cell ▶▶Welcome Reception Early Bird: April 28, 2016 function and is well studied in neuroscience and cardiovascular research, ▶▶Meet-the-Experts Session Last Day to Register: May 13, 2016 and is emerging as a highly relevant pathway in many other fields ▶▶Career Oriented Workshop including microbiology and immunology. This FASEB conference has ▶▶Short talks selected from Transportation & been an important platform to present and discuss the latest research on submitted abstracts Lodging calcium signaling and calcium channels and their roles in cell physiology ▶▶Poster Sessions dedicated to and pathology. The conference is attended by leaders in the calcium trainees Official Conference Lodging: field from around the globe. By including trainees and new investigators Lisbon Marriott Hotel, Avenida dos Combatentes, Lisboa (Lisbon) as speakers and poster presenters and by programming of career Keynote Speakers Portugal development workshops, the conference actively aims to nurture the next David Clapham, Harvard Airport Information: The generation of scientists. Topics include imaging calcium signals in living University/HHMI, Boston closest airport is the Lisbon tissues, calcium in mitochondria & organelles, store-operated calcium Rosario Rizzutto, University Portela Airport (LIS), which is 4.3 entry, calcium in immunity & infection, calcium channel structure and of Padua, Padua, Italy miles or 6.9 kilometers from the function, cell physiology of calcium signals, calcium in disease, and late- Lisbon Marriott Hotel. breaking topics in calcium signaling. Conference Organizers Stefan Feske, M.D., New York University School of Medicine Murali Prakriya, Ph.D., Northwestern University, Feinberg School of Medicine

6 FASEB Science Research Conferences 2016 Science Research Conferences 2016 Cell Signaling in Cancer: From Mechanisms to Therapy June 5-10 2016, Base Village Conference Center, Snowmass Village, CO

This SRC focuses on understanding the molecular and cellular Highlights Important Deadlines mechanisms of signaling in cancer in order to develop effective ▶▶Welcome Reception Early Bird: April 21, 2016 therapies. Specifically, the driving force behind this meeting is that ▶▶Meet-the-Experts Session Last Day to Register: May 6, 2016 understanding cancer at the molecular and cellular level opens the ▶▶Career Oriented Workshop Transportation & arena for novel therapeutic strategies. The meeting will cover cancer ▶▶Short talks selected from from the biochemical to the therapeutic level. Focus on genomics, submitted abstracts Lodging spatial aspects of signaling, and patient data will be a new strength of ▶▶Poster Sessions dedicated to Official Conference Lodging: the meeting, which formerly focused on lipid signaling in cancer. This trainees Base Village Conference Center, 84 conference broadens the mechanistic/biochemical aspect historically Carriage Way, Snowmass Village, CO represented at the meeting to cover all signaling pathways relevant Keynote Speaker Airport Information: Snowmass to developing therapies for cancer. The conference will provide ample Village is just ten miles from the Joseph Schlessinger, Aspen-Pitkin County Airport (ASE), opportunities for informal interaction to foster collaboration and William H. Prusoff, Professor and 220 miles west of the Denver promote the exchange of ideas. of Pharmacology; Chair, International Airport (DEN) Pharmacology; Director, Cancer Biology Institute Conference Organizers Alexandra Newton, University of California San Diego John Scott, University of Washington John Brognard, Cancer Register Research UK Manchester Now! Institute, University of Manchester

The Consortium for Orthodontic Advances in Science & Technology (COAST) 2016 Workshop on “Personalized and Precision Orthodontics” September 8-11, 2016, Marriott West Palm Beach, West Palm Beach, FL

The COAST 2016 SRC focuses on new knowledge relevant to the Highlights Important Deadlines orthodontic field. One of the exciting prospects to emerge from the ▶▶Welcome Reception Early Bird: July 25, 2016 completion of the human genome in 2003, is personalized medicine, ▶▶Meet-the-Experts Session Last Day to Register: August 7, and by extension precision medicine. Personalized medicine involves ▶▶Short talks selected from 2016 combining unique comprehensive data – genetic, genomic, clinical and submitted abstracts Transportation & environmental – about a person to make treatment and prevention as ▶▶Poster Sessions for trainees individualized as the condition being considered. Lodging Keynote Speakers Official Conference Lodging: Both new and old individualized orthodontic approaches must be James Cray, MUSC Marriott West Palm Beach, 1001 compared through cost/benefit analyses to identify areas of needed Okeechobee Boulevard, West Palm research and technical developments to further improve the delivery Chai Yang, USC Beach, FL of quality orthodontic care. This sort of exploration and analyses are Laura Iwasaki, UMKC Airport Information: Palm Beach indicated, for example, for individual diagnostics (e.g. 2D versus 3D Sunil Kapila, UM International Airport (PBI) is less than imaging via ionizing versus non-ionizing methods; use biomarkers and Jeff Nickel, UMKC 3 miles from the Marriott West Palm genetic profiling) as well as for individualized approaches to achieve Beach. Fort Lauderdale airport (FLL) Conference Organizers is one hour away. efficient non-surgical and surgical correction of orthodontic malocclusions Drs. Jeff Nickel and Laura (e.g. effects of applied vector mechanics, customized appliances, Registration Rates Iwasaki, University of Missouri corticotomies, robotics and fast-prototyping). Single: $1,100; Double: $885 Kansas City Double with guest: $1,635 The conference will focus on groundbreaking research in areas relevant to Dr. Sylvia Frazier Bowers, Guest fee: $750; Offsite: $900 current and future orthodontic therapies. More than 20 speakers will present University of North Carolina innnovative ideas and approaches that will have an impact on orthodontic Dr. Sunil Kapila, University of practice for the next 25 years. Topics of focus will vary from molecular Michigan management of human craniosynostosis to behavioral analyses of muscle Dr. David Covell, Oregon Register function. Five keynote speakers will lead audience-speaker discussion and Health Science University Now! debate on how to take laboratory innovations to the chairside. Dr. Saran Huja, University of Kentucky

Register Now! www.faseb.org/SRC 7 2016 Science Research Conferences Dynamic DNA Structures in Biology July 10-15, 2016, The Vermont Academy, Saxtons River, VT

For decades after its discovery, genomic DNA was believed to exist only as a Highlights Important Deadlines right-handed, double helix known as B-DNA. Its sole functions were to serve Welcome Reception ▶▶ Early Bird: May 26, 2016 as a template for RNA synthesis or as a template for the production of identical ▶▶Meet-the-Experts Session Last Day to Register: June 10, duplexes during chromosome replication. These core beliefs were shaken by ▶▶Short talks selected from the discovery that DNA is covalently modified and packaged into chromatin, submitted abstracts 2016 and that the molecule can form an enormous variety of non-B alternative ▶▶Poster Sessions dedicated to structures, including cruciforms, a left-handed helix, three- and four-stranded trainees Transportation & helices, and slip-strand configurations. Transient denaturation of the duplex Lodging Keynote Speaker during all major DNA transactions requires chromatin modifications and Official Conference Lodging: promotes dynamic transitions to non-B DNA structures. Further, repetitive Sergei Mirkin, Tufts Vermont Academy, 10 Long DNA sequences, which are highly overrepresented in genomic DNA, are University Walk, Saxtons River, VT particularly prone to structural transitions. Studies conducted in many labs Conference Organizers Airport Information: Vermont worldwide have confirmed that structural transitions are not only central Academy in Saxtons River, to normal functions of the genome but also are responsible for occasional Sue Jinks-Robertson, Vermont is 130 miles from Logan malfunctioning that leads to a disease state. The most striking example is Duke University International Airport (BOS) in Boston, Massachusetts and 110 miles from Catherine Freudenreich, expansion of structure-prone DNA repeats, which is responsible for more than Bradley International Airport (BDL) 30 hereditary neurological and developmental diseases. Tufts University near Hartford, Connecticut. Susan Lovett, Brandeis This SRC is the fourth in a series of highly interactive meeting that University brings together a diverse, international community of researchers who maintain a “DNA-centric” view of basic biological processes. Attendees will include those interested in disease-causing repeat expansions, chromatin dynamics, chromosome fragility related to transcription and replication, and the biological roles of unusual, non-B DNA structures. Morning and evening scientific sessions featuring established and new investigators, short talks with preference given to trainees, and afternoon Register poster sessions will further foster the exchange of ideas and facilitate the Now! establishment of new collaborations.

3rd International Conference on Retinoids June 19-24, 2016, Marriott West Palm Beach, West Palm Beach, FL

With the discovery of the nuclear retinoid receptors, retinoic acid receptors Highlights Important Deadlines (RARs) and retinoid X receptors (RXRs), the retinoid field has been implicated ▶▶Welcome Reception Early Bird: May 5, 2016 in new areas of scientific inquiry including metabolism, metabolic diseases, ▶▶Meet-the-Experts Session Last Day to Register: May 20, and neurobiology. The demonstration that RXRs serve as master regulators ▶▶Short talks selected from 2016 and signal integrators facilitated transcriptional crosstalk with retinoids submitted abstracts Transportation & and other nuclear receptor superfamily members has broadened interest ▶▶Poster Sessions dedicated to in retinoid biology and pharmacology. Efforts to study retinoid down- trainees Lodging stream signaling effects accelerated discoveries made beyond the nuclear Official Conference Lodging: receptors themselves. Keynote Speaker Marriott West Palm Beach, 1001 Okeechobee Boulevard, West Palm Mount Progress has been made in identifying, cloning, and analyzing a family of Samuel Waxman, Beach, FL Sinai Medical School enzymes critical for the synthesis and degradation of retinoids. Many proteins Airport Information: Palm Beach involved in regulation of retinoid metabolism, homeostasis, and signaling Conference Organizers International Airport (PBI) is less than pathways are being explored as potential therapeutic and preventive targets. Ethan Dmitrovsky, 3 miles from the Marriott West Palm While retinoid toxicities have limited their application in the clinic, the recent University of Texas, MD Anderson Beach. Fort Lauderdale airport (FLL) is one hour away. discovery of retinoid receptor selective agonists and antagonists and of multiple Cancer Center novel non-genomic retinoid signaling pathways provided ample opportunities Natalia Y. Kedishvili to refine retinoid chemistry and to broaden clinical applications. Receptor- Schools of Medicine selective retinoids retain desired pharmacologic activities, but have reduced and Dentistry, University of toxicities. Exciting examples are the of rexinoids to treat Alzheimer’s disease and Alabama at Birmingham Register the physiologic morphogen for T regulatory cells. Timely communication of Now! cutting-edge insights in this field is needed to advance retinoid basic science and biology and to realize public health benefits from this.

8 FASEB Science Research Conferences 2016 Science Research Conferences 2016 Folic Acid, Vitamin B12, and One-Carbon Metabolism August 7-12, 2016, The Steamboat Grand Resort, Steamboat Springs, CO

One-carbon metabolism and related dietary factors (folic acid and Highlights Important Deadlines vitamin B12, as well as vitamin B6, choline, riboflavin, methionine, serine, ▶▶Welcome Reception Early Bird: June 23, 2016 cysteine, and others) play important roles in a vast array of essential ▶▶Meet-the-Experts Session Last Day to Register: July 8, 2016 physiological functions. Disruptions of one-carbon metabolism due to ▶▶Short talks selected from dietary, pharmacological, environmental, and genetic factors impact most submitted abstracts Transportation & of the major health issues of our time, including vascular disease, cancer, ▶▶Poster Sessions dedicated to Lodging neurodegenerative disease, birth defects, and comorbidities associated trainees Official Conference Lodging: with obesity and diabetes such as renal disease. Steamboat Springs Resort, 2305 Mt Keynote Speakers Werner Cir, Steamboat Springs, CO. This conference has embraced an integrative philosophy that brings Ralph Green, MD, PhD Airport Information: The together basic researchers, physician scientists, and policy makers to share University of California, Davis Steamboat Grand Resort is 22 miles cutting edge research and to discuss its ramifications for health at both Paul Golding, Australia. from the Steamboat-Yampa Valley Regional/Hayden Airport (HDN) the personal and population levels. For 2016, in addition to updates on Keynote Address “Experimental new findings related to the fundamental biochemistry of folates, B12, and and 155 miles northwest of Denver Folate and B12 Deficiencies in International Airport (DIA). one-carbon metabolism, session topics will focus on (1) the intersection a Human Subject: A Personal of one-carbon metabolism and lipid metabolism, (2) the emerging roles Journey” of factors such as hydrogen sulfide and choline-related metabolites in Mavis Agbandje-McKenna, health, (3) the effects of B vitamin deficiencies and excesses during in utero Ph.D., University of Florida and post-natal development on adult phenotypes, (4) the influence of one-carbon metabolism on the brain in development and aging, (5) new Conference Organizers developments in the area of cancer therapeutics and drug delivery, and (6) Joshua W. Miller, PhD, Rutgers, the potential impact of excess folic acid exposure on health. Attendees can The State University of New expect thought-provoking oral communications from established leaders Jersey in the field, ample opportunities for students and post-doctoral trainees Ralph Green, MD, PhD Register to present their work in both oral and poster sessions, and formal and University of California, Davis Now! informal opportunities to exchange ideas and establish new collaborations.

Functional Disulfide Bonds in Health and Disease August 14-17, 2016, The Steamboat Grand Resort, Steamboat Springs, CO

Most proteins are chemically modified after they are made to control Highlights Important Deadlines how, when, and where they function. It was thought that only the amino ▶▶Welcome Reception Early Bird: June 30, 2016 acid side chains and the peptide bonds of proteins were chemically ▶▶Meet-the-Experts Session Last Day to Register: July 15, 2016 modified. We now know that the disulfide bonds of proteins are also ▶▶Short talks selected from modified. Some disulphide bonds are cleaved in the mature protein to submitted abstracts Transportation & control function. Cleavage of a functional disulfide in a protein changes ▶▶Poster Sessions dedicated to Lodging its bioactivity. Changes in ligand binding, substrate hydrolysis, proteolysis, trainees Official Conference Lodging: or oligomer formation have been described. The functional disulfides are Steamboat Springs Resort, 2305 Mt cleaved by reductases or by thiol–disulfide exchange. Viral, bacterial, plant, Keynotes Speakers Werner Cir, Steamboat Springs, CO. and mammalian proteins have been found to be regulated by functional Arne Holmgren, Karolinska Airport Information: The disulfides, so this mechanism of protein control operates in all life forms. Institute Steamboat Grand Resort is 22 miles Jon Beckwith, Harvard University from the Steamboat-Yampa Valley The early indications are that cleavage of disulphide bonds may rival Regional/Hayden Airport (HDN) proteolysis of peptide bonds as a means of protein control. Peter Cresswell, Yale University and 155 miles northwest of Denver This conference will focus on the functional disulfides that contribute to Julio Fernandez, Columbia International Airport (DIA). regulation of thrombosis, inflammation and immunity in mammals. How University protein function in these systems is regulated by disulfide bond cleavage Chaitan Khosla, Stanford University and the factors that cleave the bonds will be discussed. The chemistry and Conference Organizers molecular dynamics of cleavage of functional disulfides will be addressed, Philip Hogg, University of and the bioinformatic and experimental approaches used to identify and Sydney study these bonds will be examined. Some functional disulfides have Bruce Furie, Beth Israel been linked to human disease and progress is being made on ways of Deaconess Medical Center Register targeting these bonds for new diagnostics and therapies. Small molecule Barry Coller, Rockefeller Now! inhibitors of the factors that cleave functional disulfides are in pre-clinical University and clinical development.

Register Now! www.faseb.org/SRC 9 2016 Science Research Conferences Genome Engineering: Cutting-Edge Research and Applications June 5-10, 2016, Marriott Lisbon Hotel, Lisbon, Portugal

Genome engineering is a rapidly growing discipline that seeks to Highlights Important Deadlines develop new technologies for the precise manipulation of genes and ▶▶Welcome Reception Early Bird: April 21, 2016 genomes in cellula and in vivo. In addition to its utility for advancing our ▶▶Meet-the-Experts Session Last Day to Register: May 6, 2016 understanding of basic biology, genome engineering has numerous ▶▶Short talks selected from real-world applications, ranging from correction of disease-causing submitted abstracts Transportation & mutations in humans to engineering plants that better provide fuel, food, ▶▶Poster Sessions dedicated to and industrial raw materials. The first clinical trials and patient treatments trainees Lodging using genome engineering approaches are now a reality. The scope of this Official Conference Lodging: meeting is expansive, encompassing multiple approaches for modifying Conference Organizers Lisbon Marriott Hotel, Avenida dos Combatentes, Lisboa (Lisbon) genomes – from transgenesis and gene targeting to the creation of Thierry VandenDriessche, Portugal synthetic genomes. The experimental models featured include bacteria, Free University of Brussels Airport Information: The fungi, model organisms (e.g., Drosophila, C. elegans, zebrafish, mice, rats), Charles Gersbach, Duke closest airport is the Lisbon plants, humans, and animals including livestock. We anticipate that this University Portela Airport (LIS), which is 4.3 diversity of approaches and experimental systems will create a stimulating Jens Boch, Leibniz University miles or 6.9 kilometers from the meeting environment that will enable new insights and advance the field. Hannover Lisbon Marriott Hotel. The 2016 meeting is the fourth on this topic, and we have selected speakers and designed a program to highlight the major advances since the last meeting. Additional oral presentations will be selected from submitted abstracts. There will also be the opportunity for poster presentations at a dynamic and interactive poster session. Social and recreational activities will provide all registrants, including students and Register postdoctoral fellows, with opportunities to exchange ideas and develop Now! new collaborations. It is anticipated that there will be funds available to support attendance of early career researchers.

GTPases in Trafficking, Autophagy and Disease September 18-23, 2016, Marriott West Palm Beach, FL

Arf, Arl, Rab and Rag GTPases control traffic, proteostasis, membrane Highlights Important Deadlines dynamics, signalling, and lipid metabolism. Intensive investigation of ▶▶Welcome Reception Early Bird: August 4, 2016 the cellular, molecular, and structural mechanisms has led to surprising ▶▶Meet-the-Experts Session Last Day to Register: August 18, discoveries and paradigm shifts such as non-classical interactions and ▶▶Short talks selected from 2016 modifications controlling localization and function. New fields have submitted abstracts Transportation & emerged (e.g., Rag GTPases in proteostasis), and dis-regulation of small ▶▶Poster Sessions dedicated to GTPase networks has been implicated in human disease conditions from trainees Lodging inherited disorders to complex disease states. Official Conference Lodging: Conference Organizers Marriott West Palm Beach, 1001 This SRC brings together investigators interested in trafficking Okeechobee Boulevard, West Palm regulation, membrane dynamics, proteostasis, and disease etiology for David Lambright, UMASS Beach, FL Medical School a focused meeting. Represented disciplines will include biochemists, Airport Information: Palm Beach structural biologists, membrane biologists, cell biologists, geneticists, Antonella De Matteis, International Airport (PBI) is less than bioinformaticists, systems biologists, developmental biologists, Telethon Institute of Genetics 3 miles from the Marriott West Palm neurobiologists, microbiologists, cancer biologists, virologists, and Medicine, Italy Beach. Fort Lauderdale airport (FLL) is one hour away. immunologists, and others. This exceptional diversity reflects the fundamental role of trafficking GTPases in biological processes and disease. There will be 10 sessions on topics such as activation and deactivation of GTPases, regulation of and by post translational modifications, structural and molecular mechanisms, small GTPases in the endocytic and secretory systems, small GTPases in membrane trafficking in specialized cells, autophagy, Rag GTPases, and GTPases and disease. The opening session will include an overview of the evolution of trafficking GTPases followed by 2-minute preview talks by poster presenters. Register Now!

10 FASEB Science Research Conferences 2016 Science Research Conferences 2016 IgE and Allergy, 50 Years & Onward July 24-29, 2016, Marriott West Palm Beach, Palm Beach, FL

This SRC celebrates the 50th anniversary of the discovery of IgE, the Highlights Important Deadlines last of the classes of human antibodies to be identified, by presenting ▶▶Welcome Reception Early Bird: June 9, 2016 the latest ideas in the field and looking forward to future advances in ▶▶Meet-the-Experts Session Last Day to Register: June 24, our understanding of this molecule. All aspects of IgE biology will be ▶▶Short talks selected from 2016 covered, including IgE structure and receptor interactions, biogenesis submitted abstracts Transportation & and regulation of IgE, the biology of IgE effector cells such as mast cells ▶▶Poster Sessions dedicated to and basophils, the role of IgE in allergy and immunity, and the prospects trainees Lodging for IgE-targeted therapeutic intervention in allergic disease. It will feature Official Conference Lodging: critical aspects of physiology and pathology related to allergic disease, Keynote Speaker Marriott West Palm Beach, 1001 Okeechobee Boulevard, West Palm such as the contributions of other immune effector cells, animal models, Andrew Chan, Genentech Beach, FL and the process of translation from bench to clinic. Conference Organizers Airport Information: Palm Beach The following scientists, clinicians, and regulatory experts at all levels Toshiaki Kawakami, La International Airport (PBI) is less than should attend: Jolla Institute for Allergy and 3 miles from the Marriott West Palm Beach. Fort Lauderdale airport (FLL) ▶▶Specialists in the biology of mast cells and basophils and their interplay with Immunology is one hour away. other immune cells Bridget S. Wilson, University ▶▶Specialists in immune receptor biology, including the IgE receptors (FceRI and of New Mexico Health Sciences CD23), chemokine, cytokine and negative regulatory receptors on mast cells Center and basophils Brian Sutton, King’s College ▶▶Structural biologists interested in IgE/receptor interactions and IgE/allergen London recognition ▶▶Experts in allergic diseases, including asthma, atopic dermatitis, urticaria and food allergies A number of oral presentations will be selected from the abstracts, and the selected talks, poster presentations, and recreational activities will provide students and postdoctoral fellows opportunities to exchange Register ideas and formulate new collaborations. Now!

Immunological Aspects of Obesity July 31–August 5, 2016, Big Sky Resort, Big Sky, Montana

This SRC explores the interactions between obesity and immune cells, Highlights Important Deadlines focusing on how inflammation in various organs influences obesity and ▶▶Welcome Reception Early Bird: June 16, 2016 obesity-related complications. Our understanding of adipose tissue has ▶▶Meet-the-Experts Session Last Day to Register: July 1, 2016 evolved greatly, as the obesity epidemic continues to rage. Once considered ▶▶Career Oriented Workshop Transportation & to be primarily a fuel storage organ, adipose tissue is now known to have ▶▶Short talks selected from a number of endocrine actions and immunomodulatory properties. While submitted abstracts Lodging adipocytes make up the bulk of adipose tissue by volume, this tissue also ▶▶Poster Sessions dedicated to Official Conference Lodging: houses a variety of immune cells that interact in a complex interplay of cytokines trainees Huntley Lodge, Big Sky Resort, 50 Big and contact-mediated interactions. These processes modulate immunological Sky Resort Road, Big Sky, MT and inflammatory processes throughout the body, resulting in large effects on Keynote Speaker Airport Information: The closest whole body physiology. The immunological and inflammatory influences airport to the Big Sky area is the Philipp Scherer, University of Bozeman Yellowstone International of obesity likely contribute to many related complications, such as insulin Texas, Southwestern Airport (BZN). The lodge is resistance, diabetes, cardiovascular disease, and cancer. Conference Organizers approximately one hour from the The organizers have brought together a wide and diverse range of leaders airport. Barbara Nikolajczyk, PhD, in the fields of immunology, inflammation, and obesity, to share their latest Boston University findings on this evolving field. Individual sessions will focus on the separate Alyssa Hasty, Vanderbilt roles of adaptive and innate immunity in immunometabolism; how obesity University affects inflammation in organs such as the gut, the brain, and the liver; how inflammation develops with aging, and how it resolves; and how obesity- Steven D. Mittelman, Register Children’s Hospital Los Angeles, related inflammation promotes cancer. There will be opportunity for poster University of Southern California Now! presentations and social and recreational activities, to promote discussion and networking amongst attendees, including students and post-doctoral fellows.

Register Now! www.faseb.org/SRC 11 2016 Science Research Conferences Immunoreceptors June 12-17, 2016, Base Village Conference Center, Snowmass Village, CO

The FASEB Immunoreceptors is a long lasting series of meetings and Highlights Important Deadlines have excellent reputations among immunologists. The aim of this ▶▶Welcome Reception Early Bird: April 28, 2016 meeting is to provide in-depth coverage of recent advances in the field of ▶▶Meet-the-Experts Session Last Day to Register: May 13, 2016 immunoreceptors, in a highly interactive environment. Highlighting new ▶▶Short talks selected from developments on a variety of receptors that play key roles in the immune submitted abstracts Transportation & system, it will have a particular emphasis on antigen receptors, adhesion ▶▶Poster Sessions dedicated to Lodging molecules, complement receptors, immunoglobulin family receptors trainees Official Conference Lodging: and Fc receptors. This theme has enormous relevance for both academic Base Village Conference Center, 84 research and biotech/pharmaceutical industries because the critical Keynote Speaker Carriage Way, Snowmass Village, CO roles of immunoreceptors play in immune system and many new drugs Ronald N. Germain, M.D., Airport Information: Snowmass reaching the clinic or in development are targeting immunoreceptors and/ Ph.D., National Institute of Village is just ten miles from the Aspen-Pitkin County Airport (ASE), or associated ligands. The meeting will thus have a broad span from basic Allergy and Infectious Diseases, National Institutes of Health and 220 miles west of the Denver research to clinical application. International Airport (DEN) Conference Organizers Jeanette Leusen, University Medical Center Utrecht Sally Ward, Texas A&M Health Science Center

KLF and Sp Transcription Factors in Disease and Regenerative Medicine August 7-12, 2016, Base Village Conference Center, Snowmass Village, CO

This SRC will focus on the genetics, biochemistry, and biology of Krüppel-like Highlights Important Deadlines factors (KLFs) as well as their structurally and functionally related, specificity ▶▶Welcome Reception Early Bird: June 23, 2016 proteins (Sps) and impact on human diseases. It will discuss the application of ▶▶Meet-the-Experts Session Last Day to Register: July 8, 2016 KLF/SP-based tools to gene editing and cell-based therapies for regenerative ▶▶Short talks selected from medicine (iPS cells). KLFs/SP proteins constitute a single family of zinc finger- submitted abstracts Transportation & containing transcription factors that exhibit homology to the Drosophila ▶▶Poster Sessions dedicated to Lodging gap gene product, Krüppel. There are at least 18 KLFs and 9 Sp proteins, with trainees Official Conference Lodging: a multitude of important functions including regulation of proliferation, Base Village Conference Center, 84 differentiation, inflammation/immunity, metabolism, and carcinogenesis. Conference Organizers Carriage Way, Snowmass Village, CO Dysregulation of KLF/SP-mediated pathways contributes to pathological Raul Urrutia, Mayo Clinic Airport Information: Snowmass states such as obesity, cancer, and inflammatory conditions. Recent studies Village is just ten miles from the Goutham Narla, Case Aspen-Pitkin County Airport (ASE), indicate that many of these transcription factors have the ability to reprogram Western University and 220 miles west of the Denver somatic cells to inducible pluripotent stem (iPS) cells, and to maintain the Mona Nemer, University of International Airport (DEN) pluripotent state of embryonic stem cells. Molecular insights derived from Ottawa zinc finger-DNA interactions has given rise to a new area of research that is Masatsugu Ema, Shiga growing exponentially, gene-editing by artificial KLF-like zinc finger proteins University of Medical Science that allow for in vivo gene mutation, mutation repair, deletions, insertion, and other type of engineering for both research and medical practice. This truly Register international meeting, will explore the use of Zinc finger nucleases, TALENS, Now! and CAS/CRISPR systems. Many additional and novel roles for various Sp/KLFs in normal and disease states are only now being fully studied and explored.

12 FASEB Science Research Conferences 2016 Science Research Conferences 2016 Lipid Droplets: Dynamic Organelles in Metabolism and Beyond July 24-29, 2016, Base Village Conference Center, Snowmass Village, CO

This SRC will bring together researchers in these lipid droplet-related Highlights Important Deadlines fields and will capture the ongoing excitement and rapid expansion of ▶▶Welcome Reception Early Bird: June 9, 2016 lipid droplet research. There will be cutting-edge presentations on the ▶▶Meet-the-Experts Session Last Day to Register: June 24, 2016 biophysics of lipid droplets, on lipid droplet biogenesis and turnover, on ▶▶Career Oriented Workshop Transportation & the role of lipid droplets in exercise physiology and in various diseases ▶▶Short talks selected from Lodging as well as on their industrial use for the production of biofuels and submitted abstracts bioplastics. This meeting continues to represent the major international Official Conference Lodging: ▶▶Poster Sessions dedicated to Base Village Conference Center, 84 meeting dedicated to lipid droplets. trainees Carriage Way, Snowmass Village, CO The conference represents the diversity of science in this field with Airport Information: Snowmass Keynote Speaker invited speakers from North America, Europe, Brazil, Israel, China, and Village is just ten miles from the Hugo Bellen, Baylor College of Australia. It will include presentations spanning basic to clinical research Aspen-Pitkin County Airport (ASE), Medicine and 220 miles west of the Denver in academia and industry. There will be many opportunities for junior International Airport (DEN) scientists to present their work and to meet and exchange ideas with Conference Organizers experts in the field. Fifteen talks will be chosen from submitted abstracts. Michael A. Welte, University of Additionally there will be four poster sessions, two Meet-the-Experts Rochester roundtable discussions on career issues and new technologies as well as Perry Bickel, University of Texas social and recreational activities. Southwestern Medical Center

Liver Biology: Fundamental Mechanisms and Translational Applications June 26-July 1, 2016, Marriott West Palm Beach, Palm Beach, FL

This SRC gathers the worldwide leading liver experts to cover the most Highlights Important Deadlines recent developments in basic liver biology and the pathophysiology of ▶▶Welcome Reception Early Bird: May 12, 2016 liver disease. The unique combination of researchers from different areas ▶▶Meet-the-Experts Session Last Day to Register: May 27, 2016 and both basic and clinical backgrounds truly links the bench to bedside ▶▶Short talks selected from concept in all relevant liver diseases. The conference spans a wide range submitted abstracts Transportation & of topics relevant to understanding and solving key questions that will ▶▶Poster Sessions dedicated to Lodging ultimately open the gate to medicine of the future. It will cover all aspects trainees Official Conference Lodging: of hepatocyte, cholangiocyte, hepatic stellate cell, sinusoidal endothelial Marriott West Palm Beach, 1001 cell, and immune cell function in the healthy and diseased liver, their Keynote Speaker Okeechobee Boulevard, West Palm Beach, FL crosstalk and role in maintaining liver function and metabolism in normal Michael Karin, UCSD and disease states as well as mechanisms that regulate the identity and Airport Information: Palm Beach Conference Organizers International Airport (PBI) is less than fate during development and adulthood. Shelly Lu, Cedars Sinai 3 miles from the Marriott West Palm With recent advances in curing hepatitis C and the continuing obesity Beach. Fort Lauderdale airport (FLL) Robert Schwabe, Columbia is one hour away. epidemic, the landscape of liver disease is changing. For this reason, University the topic of metabolism and non-alcoholic fatty liver disease will Matias Arila, University of receive broad coverage with a wide range of experts discussing basic Navarra, Spain mechanisms of hepatic metabolism, pathways regulating the progression of non-alcoholic steatohepatitis as well as the gut-liver axis. This SRC will also provide a better understanding of the underlying biology needed to develop efficient therapeutic approaches, including hepatocellular carcinoma. Tumor biology, signalling pathways, novel targets, and the hepatic tumor microenvironment will be discussed in specific sessions. Understanding mechanisms of fibrogenesis and targets, a basis for future Register treatments, will be an integral part of the conference. Recent advances on Now! mechanisms of alcohol-induced liver disease will also be covered as well as therapeutic applications for liver stem cells.

Register Now! www.faseb.org/SRC 13 2016 Science Research Conferences Matricellular Proteins in Development, Health, and Disease July 17-22, 2016, Marriott West Palm Beach, West Palm Beach, FL

This SRC is focused on bringing together researchers from diverse fields of Highlights Important Deadlines study with a central theme: matricellular proteins. These proteins include ▶▶Welcome Reception Early Bird: June 2, 2016 but are not limited to thrombospondins and other thrombospondin repeat ▶▶Meet-the-Experts Session Last Day to Register: June 17, 2016 proteins (TSR), tenascins, osteopontin, SPARC (secreted protein acidic and rich ▶▶Short talks selected from in cysteine) and SPARC-like proteins, periostin, fibulins, and the CCN family and submitted abstracts Transportation & the respective receptor and interesting proteins through which they signal. ▶▶Poster Sessions dedicated to Lodging Matricellular proteins are spatially and temporally regulated components trainees Official Conference Lodging: of the extracellular matrix (ECM) that have both short-range and context- Marriott West Palm Beach, 1001 specific functions that impact cell:cell interactions and cell:ECM interactions. Conference Organizers Okeechobee Boulevard, West Palm Beach, FL Matricellular proteins are becoming increasingly appreciated as critical Amy D. Bradshaw, Medical mediators of tissue homeostasis. In addition, a number of matricellular proteins University of South Carolina Airport Information: Palm Beach Jeff Isenberg, University of International Airport (PBI) is less than have been recently recognized as key factors in pathogenesis of numerous 3 miles from the Marriott West Palm diseases in various organs. For example, matricellular proteins regulate tumor Pittsburgh Beach. Fort Lauderdale airport (FLL) progression, angiogenesis, immune response, calcification, wound repair, is one hour away. cardiovascular disease, musculoskeletal disorders, and fibrosis. Emerging roles of matricellular proteins as biomarkers of disease and in tissue engineering applications represent other areas that are rapidly expanding. Understanding the cellular and molecular mechanisms of action of these proteins has generated great interest for developing new therapeutic applications. This SRC is the only international meeting that focuses on the full profile of matricellular proteins. It stands alone as being the single opportunity for the matricellular biology community to come together to share ideas and facilitate cross-fertilization of ideas. Interaction with scientists from around Register the globe on this topic is particularly advantageous for young researchers, Now! who will be exposed to the preceding knowledge base and have an opportunity to cross-fertilize their own research with a renewed perspective.

Microbial Glycobiology June 12-17, 2016, Marriott West Palm Beach, West Palm Beach, FL

The field of glycobiology itself and the subset of microbial glycobiology Highlights Important Deadlines are rapidly expanding due to their growing importance for health ▶▶Welcome Reception Early Bird: April 28, 2016 and economy. Many cutting-edge technologies are identifying ▶▶Meet-the-Experts Session Last Day to Register: May 13, 2016 or characterizing new microbial glycosylation pathways, novel ▶▶Short talks selected from bioactive glycans, a plethora of carbohydrate-active proteins, and the submitted abstracts Transportation & complexity of interactions between host and microbial systems. The ▶▶Poster Sessions dedicated to Lodging biotechnological applications of microbial glycans and enzymes with trainees Official Conference Lodging: the roles in virulence/vaccines also keep the field growing. Marriott West Palm Beach, 1001 Keynote Speaker Okeechobee Boulevard, West Palm This SRC will provide focus on the diverse topics such as host-pathogen Alisdair Boraston, Ph.D., Univ. Beach, FL interactions, the human microbiome, polysaccharide-based vaccines of Victoria, Canada Airport Information: Palm Beach and therapeutics, and industrial applications including biofilms and International Airport (PBI) is less than enzymes. The common element of glycosciences in this diverse group Conference Organizers 3 miles from the Marriott West Palm fuels the collaborative projects and the cross-fertilization of ideas that Paul L. DeAngelis, Ph.D., Beach. Fort Lauderdale airport (FLL) is one hour away. make this field exciting for many researchers in academia and industry. University of Oklahoma Health The organizers and chairs will invite persons to speak on a wide variety Sciences Center of subject matter (model systems, diseases, macromolecules, etc.) and Mathew DeLisa, Ph.D., Cornell technologies (genetics, mass spectroscopy, X-ray, NMR, etc.). Some short University talks in various sessions will be selected from submitted abstracts. The Marco Moracci, Ph.D., Inst. of poster sessions will provide opportunities to learn and network. The Biosciences & BioResources, Italy close proximity to the sea offers venues to more informal events. Nina M. van Sorge, PharmD, Register Ph.D., Univ Medical Centrum Now! Utrecht, The Netherlands

14 FASEB Science Research Conferences 2016 Science Research Conferences 2016 Molecular Biophysics of Membranes July 10-15, 2016, Base Village Conference Center, Snowmass Village, CO

This SRC will focus on biophysical and structural principles explaining Highlights Important Deadlines molecular mechanisms in membranes and underlying membrane ▶▶Welcome Reception Early Bird: May 26, 2016 structure and function. Membranes form the defining boundaries of cells ▶▶Meet-the-Experts Session Last Day to Register: June 10, and their organelles. Many metabolic and regulatory functions of cells ▶▶Short talks selected from 2016 are carried out by membrane proteins including receptors, transporters, submitted abstracts Transportation & ion channels, proteins involved in signal transduction and energy ▶▶Poster Sessions dedicated to Lodging conversion, and many more. All these proteins function in the context of trainees Official Conference Lodging: lipid bilayers that can bend, segregate components to form specialized Base Village Conference Center, 84 protein and lipid clusters, change their shapes, fuse and separate in Keynote Speakers Carriage Way, Snowmass Village, CO processes that require highly specialized molecular machines. The basis W.E. Moerner, Stanford Airport Information: Snowmass of membrane protein structure, dynamic transformation and molecular University (Nobel Laureate, Village is just ten miles from the regulation in the context of large and small membrane systems will be tentatively confirmed) Aspen-Pitkin County Airport (ASE), and 220 miles west of the Denver discussed. Program topics include protein and carbohydrate synthesis Brian Kobilka, Stanford International Airport (DEN) in the membrane, membrane signaling, G-protein coupled receptors, University (Nobel Laureate) intracellular vesicle traffic, exo- and endocytosis, virus entry, mechanisms Conference Organizers of ion channels and membrane transporters, clustering and shaping of membrane components in immune recognition, and folding of Lukas Tamm, University of membrane proteins and amyloids. Biologists will learn about cutting edge Virginia biophysical techniques of membrane biology, and biophysicists will learn Lynmarie Thompson, about the latest developments in diverse biological fields of membrane University of Massachusetts systems, including membrane signaling in cancer, membrane transport in cardiovascular disease and diabetes, synaptic transmission and amyloid Register deposition in neurological and neurodegenerative diseases, and entry Now! pathways, antibiotic resistance, and immune response in infectious diseases.

Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease Treatment Strategies July 17-22, 2016, The Vermont Academy, Saxtons River, VT

Dysfunction of the neural cardiovascular control system plays a vital Highlights Important Deadlines role in the etiology of cardiovascular diseases. By bringing together top ▶▶State-of-the-Art lectures and Early Bird: June 2, 2016 clinical and basic researchers to discuss the latest research findings, this interactive workshops on Last Day to Register: June 17, 2016 FASEB Science Research Conference will be of great interest to researchers DREADDS and Optogenetic and clinicians seeking the most up-to-date information on normal and Technologies Transportation & diseased function of the neural cardiovascular control system. Sessions ▶▶Numerous travel awards, Lodging will cover exciting development in the application of genetically encoded workshops, poster Official Conference Lodging: receptors (DREADDS) and light-activated ion channels (optogenetics) that presentation, and speaking Vermont Academy, 10 Long opportunities for junior Walk, Saxtons River, VT are enabling researchers to interrogate and repair disease-related behavior investigators and trainees. of cardiovascular control neurons with unprecedented neurochemical Airport Information: Vermont ▶▶Welcome Reception specificity and with spatial and temporal resolution. Presently, there Academy in Saxtons River, ▶▶Meet-the-Experts Session Vermont is 130 miles from Logan is sparse evidence to explain the efficacy of new surgery- and device- ▶▶Career Oriented Workshop International Airport (BOS) in Boston, based therapies for treatment of cardiovascular and related diseases. Massachusetts and 110 miles from ▶▶Short talks selected from This conference will be among the first to explore this critical knowledge Bradley International Airport (BDL) submitted abstracts gap. Sessions on surgery-based therapies will cover carotid body and near Hartford, renal nerves ablation strategies to treat drug-resistant hypertension. Keynote Speakers Sessions on device-based therapies will explore the efficacy of implanted Murray Esler, M.D. University chronic Vagus nerve and arterial baroreceptor stimulators for treatment of Melbourne, Baker Heart and of cardiovascular and metabolic diseases as well as co-morbid psychiatric Diabetes Institute disorders such as depression, anxiety and PTSD. Conference Organizers Glenn M. Toney, Ph.D., F.A.H.A., University of Texas Health Science Center at San Antonio Register Ann Schreihofer, Ph.D., Now! F.A.H.A., University of North Texas Health Science Center

Register Now! www.faseb.org/SRC 15 2016 Science Research Conferences Phospholipid Signaling in Cancer, Neurodegeneration and Cardiovascular Disease July 31-August 5, 2016, The Steamboat Grand, Steamboat Springs, CO

This SRC focuses on new developments in the biology of lipid signaling Highlights Important Deadlines with an emphasis on cancer, neuronal, and cardiovascular diseases. The ▶▶Welcome Reception Early Bird: June 16, 2016 emphasis will be on molecular, cellular, structure/function and enzymatic ▶▶Meet-the-Experts Session Last Day to Register: July 1, 2016 mechanisms of physiological signaling pathways and how defects in ▶▶Short talks selected from Transportation & these pathways contribute to the biology and pathophysiology of cancer, submitted abstracts Lodging neurodegeneration, and cardiovascular disease. These sessions will include Poster Sessions dedicated to ▶▶ Official Conference Lodging: discussions on how signaling becomes dysfunctional in diseases. There trainees Steamboat Springs Resort, 2305 Mt will be presentations on new translational approaches and therapeutic Werner Cir, Steamboat Springs, CO. targets. There will be significant representation from the pharmaceutical and Keynote Speakers Airport Information: The biotechnology industry in order to facilitate networking between industry Pietro De Camilli, Yale Steamboat Grand Resort is 22 miles and academia. The topic areas have been chosen to maximize discussion of University/HHMI from the Steamboat-Yampa Valley provocative and important developments. Sarah Spiegel, Virginia Regional/Hayden Airport (HDN) Commonwealth University and 155 miles northwest of Denver The scope of their subjects is vast, encompassing studies at the level of single International Airport (DIA). proteins as well as the pathophysiology of complex disease. The program will Conference Organizers highlight inter-disciplinary approaches and how major advances in biophysical, Richard A. Anderson, proteomic, genomic, imaging, modeling and therapeutic approaches are driving University of Wisconsin the field. The discussion forums and recreational activities will provide all Julie Saba, University of participants extensive opportunities to exchange new ideas and forge new California, San Francisco collaborations in a supportive interdisciplinary environment for participants at all stages of their research profession. We particularly wish to encourage new and junior researchers in the field to participate and are securing additional support to provide PhD/postdoctoral fellow travel awards. The scope of subjects covered encompass studies at the level of single proteins as well as the pathophysiology of complex disease. The program will highlight inter-disciplinary approaches and how major advances are Register driving the field. The discussion forums and recreational activities will Now! provide all participants opportunities to exchange new ideas and forge new collaborations.

Post-Transcriptional Control of Gene Expression: mRNA Decay July 10-15, 2016, Marriott Lisbon Hotel, Lisbon, Portugal

This SRC will present the very latest developments in this field, with Highlights Important Deadlines talks by leading international experts working with both prokaryotic ▶▶Welcome Reception Early Bird: May 26, 2016 and eukaryotic models. This unique blend from the two communities is ▶▶Meet-the-Experts Session Last Day to Register: June 10, always much appreciated by attendees and one of its main highlights. ▶▶Short talks selected from 2016 The topics covered will include events occurring at both the 5’ and submitted abstracts Transportation & 3’ ends of mRNA related to decay, the links between translation, ▶▶Poster Sessions dedicated to quality control, and mRNA stability, and the relationship between trainees Lodging RNA degradation and disease. Two full sessions will be devoted to Official Conference Lodging: mechanisms of sRNA, CRISPR RNA and miRNA regulation and how they Keynote Speakers Lisbon Marriott Hotel, Avenida dos Combatentes, Lisboa (Lisbon) pertain to mRNA stability. This provides unrestricted access to students Sloan-Kettering Chris Lima, Portugal and post-docs for dynamic discussions with more established scientists Institute Airport Information: The and potential future employers. Informal Meet the Expert sessions will Jörg Vogel, University of closest airport is the Lisbon be held over lunch, with assigned tables to selected speakers. Würzburg, Germany Portela Airport (LIS), which is 4.3 A total of nine broad-ranging sessions during the four days will present miles or 6.9 kilometers from the Conference Organizers Lisbon Marriott Hotel. 36 invited speakers at the top of their fields and two internationally Jeff Coller,The Center for RNA renowned keynote speakers, Chris Lima and Jörg Vogel. Speakers are Molecular Biology, Case Western encouraged to present their most recent and unpublished data. There Reserve University will be two poster sessions, and two or three additional speakers per Ciaran Condon, Institut de session will be chosen to give oral presentations, based on the submitted Biologie Physico-Chimique Register abstracts. This promises to be a very interesting and lively meeting in one Now! of Europe’s most beautiful cities. We hope to see you there!

16 FASEB Science Research Conferences 2016 Science Research Conferences 2016 Protein Folding in the Cell July 24-29, 2016, The Vermont Academy, Saxtons River, VT

Proper cell function requires proper protein folding. Misfolding of specific Highlights Important Deadlines proteins, caused either by mutation or environmental stress, underlies many ▶▶Welcome Reception Early Bird: June 9, 2016 human diseases, including cancer, diabetes, Parkinson’s, Huntington’s, and ▶▶Meet-the-Experts Session Last Day to Register: June 24, Alzheimer’s disease. Protein folding has been studied for decades in the ▶▶Short talks selected from 2016 test tube. While this approach continues to aid our understanding of the submitted abstracts Transportation & fundamental physical and chemical forces that govern folding, there has ▶▶Poster Sessions dedicated to also been a growing appreciation that the cellular environment presents trainees Lodging unique challenges as well as unique support systems that cannot be easily Official Conference Lodging: captured in test tube folding experiments. Understanding how proteins fold Keynote Speaker Vermont Academy, 10 Long Walk, Saxtons River, VT and misfold, and defining the mechanism of action of the cellular protein Sheena Radford, University of quality control machinery, are major goals in the quest to understand how Leeds Airport Information: Vermont Academy in Saxtons River, to keep cells healthy, and how to correct diseased cells. Conference Organizers Vermont is 130 miles from Logan This SRC is devoted to bridging the gap between understanding how Patricia L. Clark, University of International Airport (BOS) in Boston, proteins fold and the consequences for the cell should they misfold. It Massachusetts and 110 miles from Notre Dame Bradley International Airport (BDL) serves as a highly successful model for an interdisciplinary gathering James Bardwell, HHMI/ near Hartford, Connecticut that is rapidly pushing forward a frontier of scientific research, that is University of Michigan developing a scientific workforce trained at interfaces between classical disciplines, and that is leading to the development of new insights and therapeutic strategies to abrogate human diseases related to protein misfolding. The overall goals of the conference are to: (1) Facilitate new collaborations amongst scientists in diverse disciplines who study protein folding; (2) Stimulate new scientific directions by exposing investigators to emerging concepts and technologies; (3) Develop new approaches to Register identify and treat diseases arising from defects in protein conformation; Now! and (4) Enhance opportunities for women, members of underrepresented minorities, and younger scientists to succeed and contribute to the field. Protein Kinase Signaling Network Regulation July 17-22, 2016, Base Village Conference Center, Snowmass Village, CO

While recent advances in the protein kinase and protein phosphorylation Highlights Important Deadlines fields are transforming our understanding of how signaling regulates cell ▶▶Welcome Reception Early Bird: June 2, 2016 biological responses, there are still many aspects of kinase and signaling ▶▶Meet-the-Experts Session Last Day to Register: June 17, network regulation that are poorly understood, ranging from the structural/ ▶▶Career Oriented Workshop 2016 allosteric regulation of protein kinase activity to the cross-talk and feedback ▶▶Short talks selected from Transportation & mechanisms operating to regulate complex signaling network response submitted abstracts Lodging to stimulation. Speakers at this SRC will discuss novel insights in signaling ▶▶Poster Sessions dedicated to network regulation ranging from the molecular to network scale. Specific trainees Official Conference Lodging: topics include structural insights on receptor tyrosine kinase regulation, non- Base Village Conference Center, 84 Carriage Way, Snowmass Village, CO catalytic functions of protein kinases, receptor tyrosine kinase cross-talk and Keynote Speaker the impact on therapeutic development, novel tools developed through Morag Park, McGill University Airport Information: Snowmass Village is just ten miles from the protein engineering to monitor and control signaling network activation, Conference Organizers Aspen-Pitkin County Airport (ASE), new analytical technologies for quantifying signaling network activation, and 220 miles west of the Denver mechanism of resistance to clinical therapeutics, and computational Forest M. White, MIT International Airport (DEN) modeling of complex biological signaling networks. Donald Bottaro, NIH Jim Wells, UCSF A number of oral presentations will be selected from the abstracts, and the Natalia Jura, UCSF selected talks, poster presentations, and recreational activities will provide students, postdoctoral fellows, faculty members, and industry scientists opportunities to exchange ideas and formulate new collaborations.

Register Now! www.faseb.org/SRC 17 2016 Science Research Conferences Protein Phosphatases July 17-22, 2016, The Steamboat Grand Resort, Steamboat Springs, CO

This SRC focuses on emerging roles of protein phosphatases in normal Highlights Important Deadlines physiology and pathological conditions, serving as a forum to feature ▶▶Welcome Reception Early Bird: June 2, 2016 fundamental advances in structure, signaling mechanisms, and regulation ▶▶Meet-the-Experts Session Last Day to Register: June 17, 2016 and new insights on the roles of phosphatases in processes and systems ▶▶Short talks selected from ranging from the cell cycle, development and metabolism, to the immune submitted abstracts Transportation & and nervous systems. These session topics are integrated with talks ▶▶Poster Sessions dedicated to Lodging describing rapidly expanding linkages between protein phosphatase trainees Official Conference Lodging: dysfunction/dysregulation and human diseases and disorders, and Steamboat Springs Resort, 2305 Mt highlight the potential and the challenge of protein phosphatases as Keynote Speakers Werner Cir, Steamboat Springs, CO. therapeutic targets. Susan S. Taylor, University of Airport Information: The California, San Diego Steamboat Grand Resort is 22 miles The depth and breadth of conference scope make this an ideal from the Steamboat-Yampa Valley introduction for those new to the protein phosphatase field as well Conference Organizers Regional/Hayden Airport (HDN) as an informative and thought-provoking meeting for established Catherine Pallen, University of and 155 miles northwest of Denver International Airport (DIA). phosphatase researchers. It seeks to engage trainees, inspire scientific British Columbia interactions and exchanges between early career and established Martha Cyert, Stanford investigators, and to continue its productive tradition of sharing University expertise and seeding new collaborations. Selected oral presentations from abstracts, two poster sessions, informal Meet-the-Expert lunches and interaction times provide numerous opportunities for active participation and discussions. Register Now!

Renal Hemodynamics and Cardiovascular Function in Health and Disease June 19-23, 2016, Big Sky Resort, Big Sky, MT

The kidney plays a central role in cardiovascular disease. Hypertension, Highlights Important Deadlines mediated by the kidney’s ability to control the excretion of salt and ▶▶Welcome Reception Early Bird: May 5, 2016 water, is one of the major risk factors for cardiovascular disease. ▶▶Meet-the-Experts Session Last Day to Register: May 19, 2016 This SRC will focus on unpublished work that is state-of-the-art in study ▶▶Career Oriented Workshop Transportation & of cardiovascular and renal disease and hypertension. There will be ▶▶Short talks selected from Lodging sessions on both acute kidney disease and chronic kidney disease. One submitted abstracts major focus will be the contribution of obesity and metabolic diseases ▶▶Poster Sessions dedicated to Official Conference Lodging: trainees Huntley Lodge, Big Sky Resort, 50 Big to kidney disease and hypertension. New to the program is the inclusion Sky Resort Road, Big Sky, MT ▶▶Breakout session “Role of of a session on developmental programming of cardiovascular-renal Airport Information: The closest disease as many investigators are now finding that what happens Innate Immunity and Renal Diseases” airport to the Big Sky area is the in utero increases the risk for hypertension and cardiovascular-renal Bozeman Yellowstone International disease later in life. Top scientists will also present a session on genetics Keynote Speaker Airport (BZN). The lodge is and epigenetics in the kidney, a current topic of interest. Sex steroids approximately one hour from the Christopher Wilcox, M.D., airport. have been shown more recently to contribute to the mechanisms Georgetown University and responsible for kidney disease and hypertension, and may explain why Chair, Council on Hypertension blood pressure in women is less well controlled than men and why of the American Heart men have a higher incidence in end stage renal disease. As NIH has Association now mandated the inclusion of both sexes/genders in funded basic New Frontiers in Kidney research studies going forward, the inclusion of topics in women or in Research: Overview of the Field sex/gender differences in our program is timely. Finally, the role played by T cells, inflammation, and other immunological pathways in renal Conference Organizers disease and hypertension is an important research topic that has been Jane F. Reckelhoff, Ph.D., steadily gaining in interest over the past several years, and a session will University of Mississippi Medical Center Register be included on this topic that will include some of the top scientists in Now! the area. Michal Schwartzmann, Ph.D., New York Medical College

18 FASEB Science Research Conferences 2016 Science Research Conferences 2016 Retinal Neurobiology and Visual Processing July 10-15, 2016, Keystone Lodge & Spa, Keystone, CO

This SRC showcases the most recent advances in our understanding Highlights Important Deadlines of neuronal circuits responsible for retinal image processing. A broad ▶▶Welcome Reception Early Bird: May 26, 2016 range of concepts and approaches will be covered in thematic sessions ▶▶Meet-the-Experts Session Last Day to Register: June 10, led by internationally recognized researchers in the field. Topics will ▶▶Career Oriented Workshop 2016 include physical constraints on visual processing, retinal development ▶▶Short talks selected from Transportation & processing at photoreceptor and bipolar cell synapses, the functions submitted abstracts Lodging of specific types of amacrine and ganglion cells and stem cells and ▶▶Poster Sessions dedicated to regeneration. One workshop covering recent advances in retinal trainees Official Conference Lodging: connectomics is planned. Keystone Lodge & Spa, 22010 US Keynote Speaker Highway 6, Keystone, CO This conference has evolved into one of the premier meetings on Airport Information: Keystone retinal circuitry, development, and processing. It will feature long Markus Meister, Caltech is approximately 50 minutes from platform talks by internationally known researchers, junior faculty, and Conference Organizers Denver; and the Denver International advanced postdoctoral fellows. Postdocs and graduate students are Airport (DEN) is 90 miles east of Steven DeVries, strongly encouraged to present posters. Selected postdoctoral poster Keystone via Interstate 70. Northwestern University presenters will be promoted to short talks. Selected graduate student Brown poster presenters will he invited to feature their work in short “data blitz” David Berson, University talks. This conference provides a unique opportunity for retinal scientists at all levels to exchange ideas, establish collaborations, and meet new colleagues. It is anticipated that there will be funds available to support the attendance of participants.

Skeletal Muscle Satellite Cells and Regeneration July 24-29, 2016, Keystone Lodge & Spa, Keystone, CO

This SRC provides a forum for cutting-edge work in muscle satellite and Highlights Important Deadlines stem cells, including regulatory mechanisms controlling normal and ▶▶Welcome Reception Early Bird: June 9, 2016 abnormal functions of muscle stem cells in regeneration, homeostasis, ▶▶Meet-the-Experts Session Last Day to Register: June 24, hypertrophy, aging and disease. It is the only conference specifically ▶▶Career Oriented Workshop 2016 focused on muscle satellite cells and regeneration, in spite of the recent ▶▶Short talks selected from Transportation & emergence of muscle stem cells as arguably one of the most accessible submitted abstracts Lodging and well-established stem cell models available for investigating stem ▶▶Poster Sessions dedicated to cell quiescence and heterogeneity, tissue growth, regeneration, aging trainees Official Conference Lodging: and disease. This SRC attracts investigators in related fields who are Keystone Lodge & Spa, 22010 US Highway 6, Keystone, CO interested in the rapid advances in muscle stem cell research, and Keynote Speaker interdisciplinary interactions are an important draw of this meeting. Professor Sir John Gurdon, Airport Information: Keystone The Gurdon Institute, University is approximately 50 minutes from Denver; and the Denver International Scheduled sessions include satellite cell lineage specification and of Cambridge progression; extracellular signaling; intracellular signaling; roles of Airport (DEN) is 90 miles east of MRF & PAX transcription; chromatin and transcription; noncanonical Conference Organizers Keystone via Interstate 70. satellite/stem cells; disease and aging; and translation and industry. Work Robert Krauss, Icahn School of presented by invited speakers will be largely unpublished, making this Medicine at Mount Sinai meeting an excellent opportunity to gain a current perspective on work Jyotsna Dhawan, Center for being done across the field. Cellular and Molecular Biology Register Now!

Register Now! www.faseb.org/SRC 19 2016 Science Research Conferences Smooth Muscle July 17-22, 2016, Lisbon Marriott Hotel, Lisbon, Portugal

This SRC is widely regarded as the premier forum in smooth muscle Highlights Important Deadlines biology, and thus, attracts internationally recognized leaders in a ▶▶Welcome Reception Early Bird: June 2, 2016 number of fields. This is the 12th in a highly successful series of smooth ▶▶Meet-the-Experts Session Last Day to Register: June 17, muscle meetings sponsored by FASEB that have been held every 3 years ▶▶Short talks selected from 2016 since 1982. At present, this is the only international meeting that focuses submitted abstracts Transportation & on smooth muscle biology exclusively. ▶▶Poster Sessions dedicated to Lodging The conference showcases internationally-recognized investigators trainees Official Conference Lodging: using state-of-the-art technologies in genetics, bioinformatics, Keynote Speakers Lisbon Marriott Hotel, Avenida transgenesis, imaging, and high throughput “omics” (e.g., proteomics). Kenton Sanders, University dos Combatentes, Lisboa (Lisbon) As smooth muscle dysfunction underlies many acute and adaptive of Nevada-Reno, a worldclass Portugal disease processes such as cardiovascular disease, asthma, kidney failure, expert on GI smooth muscle Airport Information: The incontinence, and inflammation, the investment of the field with newer physiology closest airport is the Lisbon Portela Airport (LIS), which is 4.3 technologies and developments has created an extremely healthy and Mark T. Nelson, University of interactive environment at the meeting. miles or 6.9 kilometers from the Vermont Lisbon Marriott Hotel. The program has been designed to promote attendance of smooth muscle biologists working on a wide rage of areas and smooth muscle Conference Organizers types. Its goal is to have graduate students, scientists, post-doctoral Luis F. Santana, University of Washington fellows, and physician-scientists attend the meeting. Jonathan H. Jaggar, University Register of Tennessee Now!

The Biology of Calpains in Health and Disease July 17-22, 2016, Big Sky Resort, Big Sky, MT

This SRC brings together calpain researchers dedicated to elucidating Highlights Important Deadlines the molecular, cellular, and physiological functions of these proteases. ▶▶Welcome Reception Early Bird: June 2, 2016 Dysregulated calpain activity plays important roles in many diseases, ▶▶Meet-the-Experts Session Last Day to Register: June 17, including diabetes, muscular dystrophy, cardiovascular and pulmonary ▶▶Career Oriented Workshop 2016 diseases, neurodegeneration, and cancer. Calpains are a family of ▶▶Short talks selected from Transportation & intracellular thiol-proteases with diverse biological functions associated submitted abstracts Lodging with their ability to cleave a wide variety of proteins that regulate cellular ▶▶Poster Sessions dedicated to processes including mitogenesis, migration, invasion, differentiation, trainees Official Conference Lodging: Huntley Lodge, Big Sky Resort, 50 Big membrane repair, and programmed cell death. This has stimulated New evidence for calpain as an ▶▶ Sky Resort Road, Big Sky, MT research aimed at elucidating the structures, functions, and regulation important therapeutic target in of the 15 known mammalian calpain isoforms as well as conserved neurodegenerative diseases. Airport Information: The closest airport to the Big Sky area is the isoforms from drosophila, nematodes, and other species. Growing ▶▶Pharmacologic inhibition of Bozeman Yellowstone International evidence of calpain involvement in cancer, neurogeneration, and calpain suppresses organ Airport (BZN). The lodge is cardiovascular disease in particular are inspiring efforts to develop atrophy and a number of other approximately one hour from the novel calpain inhibitors. This SRC brings together leading experts aging symptoms airport. and trainees to present and discuss their latest unpublished findings, ▶▶Preclinical model studies showing disruption of calpain attenuates including identification of novel calpain substrates and elucidation of tumor growth and metastasis how calpain cleavage affects their functions as well as examples of how dysregulated calpain activity contributes to diseases and preclinical Keynote Speaker model studies investigating how blocking calpain may provide Chris Overall, University therapeutic benefits. Session topics will include bioinformatics of calpain of British Columbia, substrate identification, measuring calpain activity in vivo and in vitro, “Proteogenomic Approaches to calpain in autophagy, calpain in programed cell death, calpains in neural Explore Protease Functions” development and degeneration, calpain in cardiovascular disease and aging, calpain in cancer, and calpastatin and other calpain inhibitors. In Conference Organizers addition to selected invited speakers, additional talks will be selected Peter Greer, Queen’s University Register from abstracts. Poster sessions, Meet-the-Expert sessions, and informal Kevin Wang, University of Now! gatherings will provide ample opportunities to share ideas and establish Florida new interactions. Athar Chishti, Tufts University

20 FASEB Science Research Conferences 2016 Science Research Conferences 2016 The Lung Epithelium in Health & Disease July 31-August 5, 2016, The Vermont Academy, Saxtons River,

This SRC presents emerging areas of scientific interest in lung epithelial Highlights Important Deadlines biology in development, homeostasis, and disease. It addresses critical ▶▶The acknowledgment of one Early Bird: June 16, 2016 issues on lung epithelial biology such as stem cells and regenerative presentation with the Jo Rae Last Day to Register: July 1, 2016 medicine, while expanding sessions to encompass themes such as single Wright Outstanding Young cell analytical approaches, cell-cell communication within the epithelial Investigator Award Transportation & compartments as well as between epithelia and stroma, and immune ▶▶Three engaging poster sessions Lodging interactions—current subjects of high interest to the lung community ▶▶Round table session on “How Official Conference Lodging: with many great advances pending. It will provide opportunities not to Tell a Story,” focusing on Vermont Academy, 10 Long only for scientists working on lung epithelial biology, but also synergize strategies in preparing an Walk, Saxtons River, VT effective grant application interactions among attendees in all these fields. Airport Information: Vermont ▶▶Round table discussion on Academy in Saxtons River, This conference will (1) highlight the latest developments in epithelial “How to find in independent Vermont is 130 miles from Logan barrier maintenance and its disruption during acute lung injury; (2) faculty position and start a International Airport (BOS) in Boston, promote the understanding the impact of the cystic fibrosis gene on new job” Massachusetts and 110 miles from host defense to pulmonary infections; (3) connect new insights in the ▶▶Meet-the-Experts Session Bradley International Airport (BDL) near Hartford, Connecticut fields of ER stress and cell senescence to the vulnerable pulmonary epithelium of individuals at risk for pulmonary fibrosis; (4) dissect Keynote Speaker the biological distinctions between epithelial proliferation as a repair Ed Morrisey, University of Pennsylvania mechanism and tumorigenesis; (5) present the impact of the newest tools in single cell analysis on understanding lung development, Conference Organizers repair, and disease; and (6) characterize epithelial-mesenchymal Carla Kim, Ph.D., Boston interrelationships that maintain lung homeostasis and orchestrate repair Children’s Hospital and regeneration. The entire program has been designed to achieve a Michael Koval, Ph.D., Emory Register better understanding of the key clinical research issues and how they University Now! relate to basic mechanistic investigation. Hal Chapman, MD, University of California

Trace Elements in Biology and Medicine June 5-10, 2016, Big Sky Resort, Big Sky, MT

Metalloproteins represent about 30% of the proteins encoded in the Highlights Important Deadlines human genome that provide essential, non-redundant functions. ▶▶ Welcome Reception Early Bird: April 21, 2016 Deficiency in one of these proteins is commonly associated with a ▶▶Meet-the-Experts Session Last Day to Register: May 6, 2016 clinically manifested pathology. Metals such as Mn, Fe, Co, Ni, Cu, Zn, ▶▶Opening and closing Keynote and Se are essential to the virulence of human (and plant) microbial Address Sessions Transportation & pathogens. Delineation of physiologic homeostasis in humans and in ▶▶Short talks will be selected Lodging the flora and fauna upon which we rely requires understanding of the from submitted abstracts: Official Conference Lodging: mechanisms underlying metal absorption and trafficking. Interest in focus on trainees and new Huntley Lodge, Big Sky Resort, 50 Big metals in biology and medicine has intensified in recent years given the investigators Sky Resort Road, Big Sky, MT role that metals such as Fe and Cu play in neurodegenerative disorders ▶▶Poster Blitz sessions giving Airport Information: The closest and in the virulence of human pathogens. The intent of this meeting poster presenters platform airport to the Big Sky area is the Bozeman Yellowstone International is to bring together the investigators and their trainees working at the face-time to advertise their work Airport (BZN). The lodge is forefront of trace metals in biology and medicine using techniques approximately one hour from the ranging from floxed mice to micro-X-ray fluorescence imaging. Keynote Speakers airport. This SRC will open with a session on metals in human disease, Raymond Burke, Vanderbilt highlighting a keynote address from Ray Burke (Vanderbilt), titled University “Selenium Trafficking at the Blood-Brain Barrier, and Neurodegeneration.” Shelley Paine, The University of Other sessions include metals in the biosphere; metalloregulation; metal Texas/Austin imaging, quantification, and speciation; metal ion transporters; and Conference Organizers metals in protein aggregation and neurodegeneration. It closes with a second keynote session on metals and pathogenesis, with Shelly Paine Daniel Kosman, The University at Buffalo (Austin) presenting her work on iron in the virulence of Shigella and Register Vibrio. All sessions will include short talks based on abstracts submitted Svetlana Lutsenko, Johns Hopkins University Now! with an emphasis on new investigators and trainees, who will become the core of trace metals investigators in the next few decades. Amanda Bird, The Ohio State University

Register Now! www.faseb.org/SRC 21 2016 Science Research Conferences Translational Neuroimmunology: From Mechanisms to Therapeutics July 24-29, 2016, Big Sky Resort, Big Sky, MT

The interactions between the nervous and immune systems have Highlights Important Deadlines been studied for some time, largely to decipher the molecular chemical ▶▶Welcome Reception Early Bird: June 9, 2016 mechanisms of damage inflicted on the nervous system. Interesting ▶▶Meet-the-Experts Session Last Day to Register: June 24, revelations and advances continue to be made in this field, namely, ▶▶Pre-meeting workshop, titled 2016 linkages between inflammatory processes and neurodegeneration, “Introduction to Concepts, developments in bi-directional communication molecules between the Model Systems and Cutting- Transportation & CNS and the immune system, advances in imaging of the nervous system Edge Basic Neuroimmunology Lodging and the immune system, and forays into the use of stem cells in repair Concepts” Official Conference Lodging: of the neurologic system. These developments all hold promise for new Huntley Lodge, Big Sky Resort, 50 Big Keynote Speakers Sky Resort Road, Big Sky, MT therapeutic targets. A greater understanding of the biochemical and Mario Capecchi, University of molecular mechanisms underlying diseases associated with dysfunction Airport Information: The closest Utah Health Sciences Center airport to the Big Sky area is the in the neuroimmune system will undoubtedly facilitate the translational Marco Prinz, University of Bozeman Yellowstone International aspect of this field as novel therapeutic targets are moved towards human Freiburg, Germany Airport (BZN). The lodge is clinical trials. This will be facilitated by cutting-edge talks from scientists approximately one hour from the with international reputations on the topics of (1) CNS metabolism and Conference Organizers airport. the microbiome; (2) inflammation in the peripheral nervous system; (3) Tammy Kielian, University of stem cells and neuroinflammation; (4) neuroinflammatory mechanisms Nebraska Medical Center of demyelinating diseases; (5) immunity and neurodegenerative Monica Carson, University of diseases; (6) pre-clinical studies for CNS neuroinflammatory diseases; (7) California at Riverside neuroinflammation and neurotrauma; (8) neuroinflammation and host defense; and (9) the many faces of microglia. This SRC will also host a pre-meeting workshop entitled “Introduction to Concepts, Model Systems and Cutting-edge Methodologies in Neuroimmunology,” which will provide attendees with basic neuroimmunology concepts and discuss the role of inflammation in disorders affecting the nervous system. This SRC conference provides Register ample presentation and discussion time, abstracts from junior scientists Now! and trainees , open discussion time to foster ongoing collaborations, and highly interactive poster sessions.

Ubiquitin & Cellular Regulation June 12-17, 2016, Big Sky Resort, Big Sky, MT

This SRC brings together leading international investigators in the Highlights Important Deadlines field, junior scientists, and those who have recently entered the field. ▶▶Welcome Reception Early Bird: April 28, 2016 Structural, molecular, and cellular biology continues to reveal both ▶▶Meet-the-Experts Session Last Day to Register: May 13, 2016 novel and common themes in protein ubiquitination, and these drive ▶▶Career Oriented Workshop drug discovery, particularly in the areas of cancer biology, infectious Transportation & ▶▶Short talks selected from Lodging diseases, muscle wasting, and neurologic diseases. New discoveries submitted abstracts Official Conference Lodging: continue to expand the basic and clinical potential of understanding ▶▶Poster Sessions dedicated to Huntley Lodge, Big Sky Resort, 50 Big Ub and Ubls. Nine platform sessions and two poster sessions will reflect trainees Sky Resort Road, Big Sky, MT the broad diversity of research in the field and will include topics such Airport Information: The closest as mechanisms of Ub conjugation and deconjugation, cell cycle and Keynote Speaker airport to the Big Sky area is the Vishva Dixit, Genentech signaling, physiology and development, and pathology and therapy. Bozeman Yellowstone International Each session will include both invited speakers and short talks chosen Airport (BZN). The lodge is Conference Organizers from submitted abstracts to ensure good representation of those who approximately one hour from the are new to the field and/or young investigators. Lively and well-attended Rachel E. Klevit, University of airport. Washington poster sessions offer a venue where students and postdoctoral fellows can exchange ideas with each other and with senior scientists. Ray Deshaies, Caltech

22 FASEB Science Research Conferences 2016 Science Research Conferences 2016 Virus Structure and Assembly July 24-29, 2016, The Steamboat Grand Resort, Steamboat Springs, CO

This SRC will focus on virus assembly, virus structure, and structure- Highlights Important Deadlines based mechanisms of virus replication. Studies in these areas provide ▶▶Welcome Reception Early Bird: June 9, 2016 insight into a multitude of cellular processes from the perspective of ▶▶Meet-the-Experts Session Last Day to Register: June 24, relatively simple and relatively easy to manipulate organisms, viruses ▶▶Career Oriented Workshop 2016 and bacteriophages. Moreover, these cellular processes are critical for ▶▶Short talks selected from Transportation & the pathogenicity of infectious viruses and therefore are targets for submitted abstracts Lodging established and novel anti-viral therapeutics. Many new therapies are ▶▶Poster Sessions dedicated to a direct result of basic scientific investigations, which have been the trainees Official Conference Lodging: emphasis of past FASEB Virus Structure and Assembly conferences. Steamboat Springs Resort, 2305 Mt Keynote Speaker Werner Cir, Steamboat Springs, CO. This SRC will integrate viral genomics, molecular virology, biophysical Timothy Baker, University of Airport Information: The virology, and structural virology. Invited speakers will showcase diverse California San Diego Steamboat Grand Resort is 22 miles approaches to study virus assembly and structure, viral replication, from the Steamboat-Yampa Valley entry into host cells (infection) the interactions and co-evolution Conference Organizers Regional/Hayden Airport (HDN) between viruses and hosts, and the deep connections between and 155 miles northwest of Denver James Conway, University of International Airport (DIA). viruses from all kingdoms of life. The meeting will address recent Pittsburgh developments in the area of structure determination, such as in single Rebecca Craven, Penn State particle electron-microscopic image reconstruction, tomography and University College of Medicine asymmetric reconstruction where advances continue to be rapid and exciting. The use of viruses as biomedical and biotechnological tools, and their overall evolutionary trajectories will be featured sessions. Viral genetics, cell biology, and molecular biology will round out this multi-faceted meeting. The diversity of the scientific program and the ample opportunity for interactions among attendees encourages the development of new cross-disciplinary collaborations. Register Now!

Yeast Chromosome Structure, Replication and Segregation July 31-August 5, 2016, Base Village Conference Center, Snowmass Village, CO

Understanding the intricately interconnected systems that regulate Highlights Important Deadlines chromosome structure, replication, and segregation are a major challenge ▶▶Welcome Reception Early Bird: June 16, 2016 in modern cell biology. Yeast systems continue to provide key biological ▶▶Meet-the-Experts Session Last Day to Register: July 1, 2016 insights and technical breakthroughs that drive progress in the fields of ▶▶More than 20 talks selected Transportation & DNA replication, recombination and repair, chromatin structure, spindle from submitted abstracts Lodging assembly and regulation, kinetochore structure and function, telomere ▶▶Poster Sessions dedicated to biology, and nuclear organization. trainees Official Conference Lodging: Base Village Conference Center, 84 Hike with the experts on a This SRC brings together leaders in these fields, young up-and-coming ▶▶ Carriage Way, Snowmass Village, CO faculty, and the students and postdocs who are actually doing the work fabulous afternoon trek in the Rocky Mountains Airport Information: Snowmass to share the most current technical and conceptual advances, meet their Village is just ten miles from the colleagues from across the globe, and establish new collaborations. A Keynote Speaker Aspen-Pitkin County Airport (ASE), and 220 miles west of the Denver tradition of international participation—with strong participation from Steven P. Bell, MIT Asia and Europe—ensures broad representation of ideas. Building on International Airport (DEN) a long series of successful meetings, this meeting is a not-to-be-missed Conference Organizers gathering of the most important work in the field. The meeting is known Nick Rhind, UMass Med School for a congenial and interactive atmosphere in which all the posters are Jennifer Gerton, Stowers up for the whole meeting and everybody comes to the evening poster Institute sessions to talk science, make new connections, and renew old ones. This incarnation will include sessions on chromosome and chromatin structure, Register DNA replication, meiosis and recombination, telomeres, kinetochores and Now! spindles, DNA repair, nuclear organization, and cell cycle control.

e•Engag Thank You! Organize! or e•C pl o x n On behalf of the organizers and attendees, Do you have a passion for your scientific t E r • i FASEB would like to thank all the sponsors n b field? r u

t of the 2015 FASEB Research Conferences. e

Organize a FASEB SRC. Organizing meetings is a e

These contributions were invaluable to the community responsibility. It fosters team building and L overall success of the conference and en- w provides a valuable learning experience. If you are c w r abled the organizers to provide more than a science professional holding an advanced medical w s / 350 scholarships, travel awards, and poster or doctoral degree and are active in scientific research, .f g a s e . or prizes to junior trainees, as well as provide you may submit a proposal to organize a conference with b support to invited speakers. Please visit FASEB. our acknowledgment page to see all the sponsors who have made the 2015 Learn. FASEB SRCs provide ample networking opportunities for both seasoned FASEB SRC’s a huge success. scientists and junior investigators, as attendees are encouraged to present posters and short talks, eat meals together, and converse with leaders in the field during 2016 Sponsor Benefits Meet-the-Expert Sessions. Explore. To submit a proposal, please email [email protected], requesting PLATINUM LEVEL an application. Write “Proposal Application” and the year of the proposed conference $10,000 or more in the subject line of the email. FASEB is currently accepting 2018 conference ▶▶Option to display a table-top exhibit at proposals until Monday, September 26, 2016. For more information, visit www. the sponsored conference faseb.org/src. ▶▶One (1) complimentary single occupancy Engage. FASEB SRCs encourage dialogue among prominent scientists, faculty, post- registration doctoral fellows and graduate students who are working in areas experiencing rapid Company logo in the program ▶▶ scientific advances and conducting cutting-edge research. Meetings are traditionally ▶▶Logo and link to your company on the small, averaging between 100 and150 participants, and held over five days. FASEB SRC web page Contribute. FASEB SRCs are organized by leading investigators in their fields of ▶▶Distribution of company brochure at the sponsored conference expertise.

GOLD LEVEL $5,000 - $9,999 ▶▶One (1) complimentary single occupancy Current Sponsors 2016 registration PLATINUM SILVER BRONZE ▶▶Company logo in the program IO Therapeutics, Inc. FThree Foundation Carl Zeiss Microscopy, LLC ▶▶Logo and link to your company on the Takeda Pharmaceuticals USA, Mead Johnson & Company, Cell Signaling Technology, Inc FASEB SRC web page Inc. LLC Thorlabs, Inc ▶▶Distribution of company brochure at the European Association for the Cleave Bioscience, Inc. RNA Society sponsored conference Study of the Liver DMT-USA, Inc. AAAS (SCIENCE Magazine) MD Anderson Cancer Center Kanyr Phama, Inc. Cell Stress Society, Inc. Lifesensors, Inc. E3X BIO, Inc. SILVER LEVEL GOLD $2,000 - $4,999 Arvinas, Inc. Seahorse Bioscience Samauel Waxman Cancer Merrimack Pharmaceuticals The Menkes Foundation, Inc. ▶▶Company logo in the program Research Foundation New England Biolabs, Inc Grunenthal Gmbh UAB Comprehensive Cancer ▶▶Logo and link to your company on the Cayman Chemical Company, Nature America (NSMB) Center FASEB SRC web page Inc. Thermo Fisher Scientific March of Dimes Wilson Disease Association Milyenyi Biotec Distribution of company brochure at the ▶▶ Nutrix, Inc. Argen-X BVBA sponsored conference Plum Foundation MacroGenics, Inc Avanti Polar Lipids Lewis Katz School of BRONZE LEVEL Tarrex Biopharma Ltd. Medicine (Temple $1,999 OR LESS AAT Bioquest University) ▶▶Company logo in the program Avanti Polar Lipids Caisson Biotech, LLC Chroma Technology Corp ▶▶Distribution of company brochure at the sponsored conference New England Biolabs, Inc.

If you are interested in providing support please contact: Sherri-Gae Scott, Ph.D., Grants Proposal Manager, [email protected]

24 FASEB Science Research Conferences 2016 Register Now! www.faseb.org/SRC 24