Write-Up of the Event

Total Page:16

File Type:pdf, Size:1020Kb

Write-Up of the Event 4th ISMB Symposium 17-18 June 2010 Write-up of the event This article was written by Dr. Clare Sansom (Department of Biological Sciences, Birkbeck, University of London). The Institute of Structural and Molecular In introducing the symposium, Mary Collins, Biology holds a research symposium every two the Executive Dean of the Faculty of Life years. Its fourth such symposium was held at Sciences at University College London, one of its constituent institutions, University congratulated ISMB’s director, Gabriel College London, on June 17 and 18, 2010. As Waksman, on putting together “one of the before, the symposium brought together all highest quality structural biology meetings” researchers and postgraduate students of the that she had been to in a long time. five departments from UCL and Birkbeck Waksman, whose many honours include College making up the ISMB together for a Fellowship of the Academy of Medical two-day lecture programme. The 2010 Sciences and membership of the European symposium, attended by all researchers and Molecular Biology Organisation, is the head of postgraduate students of the five UCL and both the Department of Biological Sciences at Birkbeck departments making up the Birkbeck and the Research Department of Institute, as well as many external scientists, Structural and Molecular Biology at UCL. featured twelve excellent talks. Three each were taken from four of the Institute’s six The first programme featured structural disciplinary programmes: structural biology, biology. Its speakers may have been chosen to biophysics, chemical biology and complement each other, with one bioinformatics. Each three-lecture slot representing each of the three main structural featured one speaker from the ISMB, one from biology techniques: X-ray crystallography, the UK and another from overseas: the nuclear magnetic resonance, and electron external speakers were invariably established microscopy. The first to speak was X-ray research leaders, whereas most ISMB speakers crystallographer Laurence were promising principal investigators nearer Pearl, who moved very the beginning of their research careers. recently from London’s Institute of Cancer Research to head the School of Life Sciences at the University of Sussex, UK. Pearl has a long association with both Birkbeck and UCL as student, lecturer and professor. He described structural studies of a protein known as heat shock protein 90 (Hsp90), which is a molecular chaperone. The concept of chaperones is a very familiar one at Birkbeck, thanks to Helen Saibil’s ground-breaking work on the bacterial chaperone GroEL; they are proteins that help ISMB Symposium 2010 www.ismb.lon.ac.uk/symposium2010.html other proteins to attain and maintain their leaves the tunnel. NMR can give useful folded conformation. Hsp90, which enables information about the dynamics of these protein stability at a late stage of folding, is structures, and hence about the process of essential in eukaryotes. protein folding in vivo. Christodoulu described how “fingerprint” NMR spectra obtained at Pearl has studied the structure of this protein different points during the protein synthesis and its constituent domains since his time at process showed significant differences UCL in the 90s. The first structure of its N- between the folded and unfolded states of the terminal domain, which binds ATP, was emerging protein chain. He has used this published in 1998. Since then, he has been technique to investigate the folding of establishing the mechanism by which ATP proteins involved in diseases of protein binding drives a conformational change that aggregation, such as alpha-synuclein, which is leads to Hsp90 forming a dimer. When ATP implicated in Parkinson’s disease, and alpha-1 binds, a “lid” of protein structure folds down antitrypsin. He has obtained a high resolution over its phosphate groups, opening up a structure for the stalk protein on the intact hydrophobic surface that can be stabilised by ribosome and compared this to X-ray dimer formation. The chaperone’s substrate structures of this protein in isolation. He is proteins bind to the dimer, and ATP can be now developing cell-free methods for hydrolysed into ADP, after which the protein obtaining NMR samples of ribosomes that can relaxes back into its monomeric state. generate high-quality data faster and more Substrates that bind to Hsp90 include many cheaply than conventional methods, and is protein kinases, which are key targets for aiming to use these to probe the mechanism drugs against cancer; Pearl has published of protein folding – one of the “holy grails” of structural studies of Hsp90-kinase complexes structural biology – even more closely. in collaboration with Birkbeck electron microscopist Cara Vaughan. The last part of The name of Wolfgang Baumeister of the his talk was devoted to unpublished studies of Max-Planck Institute of Biochemistry, Hsp90 from plants in complex with co- Martinsried, Germany, is synonymous with chaperones that are necessary for its activity, technical developments in electron and he explained how these structures are microscopy and, particularly, the leading, in the light of the ATP “switch” development of electron tomography – described earlier, to new insights into the imaging in sections - as a tool for chaperone’s mechanism of action. understanding cell biology. This can The ISMB contribution to the structural produce relatively high biology programme was given by John resolution images of Christodoulou, who took up his position as a non-repetitive lecturer in the Research Department of structures the size of Structural and Molecular Biology at UCL in cells in their natural 2007. He uses NMR spectroscopy to study the environment. mechanism of protein folding on the Baumeister started his ribosome. These NMR studies of a large, talk, however, with an complex molecular machine in motion are all overview of more the more remarkable as, traditionally, NMR is recent work in his laboratory using single seen as a technique most suitable for studying particle analysis. He used as examples two relatively small molecules, and as the proteases involved in the protein degradation emerging protein chain is still rarely visible pathway, the proteasome, which chops even in X-ray structures of ribosomes. unwanted proteins into peptides about 8-12 amino acids long, and the TPII protease, Each ribosome is formed from one large and which breaks down those short peptides one small subunit, which only come together further. He can now obtain high quality to form the intact structure during protein structures of the proteasome, a cylindrical synthesis. The newly synthesised protein chain structure with a “cap” at each end, quickly emerges through a tunnel in the large subunit, and almost routinely, and is exploring its beginning to fold into its stable structure as it mechanism further with structural studies of ISMB Symposium 2010 www.ismb.lon.ac.uk/symposium2010.html the complex bound to proteins that intact, fully assembled amyloid fibrils using proteomics experiments have suggested as infra-red spectroscopy and electron interaction partners. microscopy. She discovered that structurally identical fibrils of different lengths form from Electron tomography explores the structures the assembly of globular subunits. The lengths of proteins in the context of intact cells or and physical properties of the fibrils depend organelles. Baumeister presented his studies on the environment in which they form, with of the nuclear pore complex through which slower growth producing longer fibrils. proteins are transported into and out of the Interestingly, she suggested that cell nucleus. Higher resolution structures of intermediates and short fibrils are more toxic protein components of the pore complex have to cells than the inert long fibrils; this insight been docked into a lower resolution structure may suggest new targets for intervention in of a section across the intact complex to amlyoid disease. produce a full model. He is now turning his attention to the human ribosome, which is Mark Williams, a lecturer in the Department larger than those of lower organisms and less of Biological Sciences at Birkbeck and tractable to other structural techniques. director of the ISMB Biophysics Centre, represented the “home team” in the The second programme, on biophysics, was biophysics section. His talk, intriguingly opened by Sheena Radford of the Astbury entitled “A Wet Walk in the Thicket of Centre for Structural Molecular Biology and Thermodynamics”, described some uses of Institute of Molecular and Cellular Biology, thermodynamics - the study of energy University of Leeds, UK. Radford’s research, conversion and heat changes - to aid the like Christodoulou’s, focuses understanding of protein complex formation. on protein folding, Whenever molecules interact, by either misfolding and disease, and covalent or non-covalent binding, heat is she is no stranger to the gained or lost. These gains and losses can be ISMB, having established measured and monitored over time using a productive collaborations technique known as isothermal titration with Gabriel Waksman and calorimetry (ITC). Helen Saibil. Early protein folding theories proposed a Williams illustrated the use of ITC using single mechanism for folding each sequence examples from the Hsp90 chaperone system into a single low-energy structure with a described by Pearl. The switch mechanism of single function. Folding is now known to be Hsp90 is driven by a conformational change
Recommended publications
  • ANNUAL REVIEW 1 October 2005–30 September
    WELLCOME TRUST ANNUAL REVIEW 1 October 2005–30 September 2006 ANNUAL REVIEW 2006 The Wellcome Trust is the largest charity in the UK and the second largest medical research charity in the world. It funds innovative biomedical research, in the UK and internationally, spending around £500 million each year to support the brightest scientists with the best ideas. The Wellcome Trust supports public debate about biomedical research and its impact on health and wellbeing. www.wellcome.ac.uk THE WELLCOME TRUST The Wellcome Trust is the largest charity in the UK and the second largest medical research charity in the world. 123 CONTENTS BOARD OF GOVERNORS 2 Director’s statement William Castell 4 Advancing knowledge Chairman 16 Using knowledge Martin Bobrow Deputy Chairman 24 Engaging society Adrian Bird 30 Developing people Leszek Borysiewicz 36 Facilitating research Patricia Hodgson 40 Developing our organisation Richard Hynes 41 Wellcome Trust 2005/06 Ronald Plasterk 42 Financial summary 2005/06 Alastair Ross Goobey 44 Funding developments 2005/06 Peter Smith 46 Streams funding 2005/06 Jean Thomas 48 Technology Transfer Edward Walker-Arnott 49 Wellcome Trust Genome Campus As at January 2007 50 Public Engagement 51 Library and information resources 52 Advisory committees Images 1 Surface of the gut. 3 Zebrafish. 5 Cells in a developing This Annual Review covers the 2 Young children in 4 A scene from Y fruit fly. Wellcome Trust’s financial year, from Kenya. Touring’s Every Breath. 6 Data management at the Sanger Institute. 1 October 2005 to 30 September 2006. CONTENTS 1 45 6 EXECUTIVE BOARD MAKING A DIFFERENCE Developing people: To foster a Mark Walport The Wellcome Trust’s mission is research community and individual Director to foster and promote research with researchers who can contribute to the advancement and use of knowledge Ted Bianco the aim of improving human and Director of Technology Transfer animal health.
    [Show full text]
  • Functional Effects Detailed Research Plan
    GeCIP Detailed Research Plan Form Background The Genomics England Clinical Interpretation Partnership (GeCIP) brings together researchers, clinicians and trainees from both academia and the NHS to analyse, refine and make new discoveries from the data from the 100,000 Genomes Project. The aims of the partnerships are: 1. To optimise: • clinical data and sample collection • clinical reporting • data validation and interpretation. 2. To improve understanding of the implications of genomic findings and improve the accuracy and reliability of information fed back to patients. To add to knowledge of the genetic basis of disease. 3. To provide a sustainable thriving training environment. The initial wave of GeCIP domains was announced in June 2015 following a first round of applications in January 2015. On the 18th June 2015 we invited the inaugurated GeCIP domains to develop more detailed research plans working closely with Genomics England. These will be used to ensure that the plans are complimentary and add real value across the GeCIP portfolio and address the aims and objectives of the 100,000 Genomes Project. They will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK as existing members of the GeCIP Board to give advance warning and manage funding requests to maximise the funds available to each domain. However, formal applications will then be required to be submitted to individual funders. They will allow Genomics England to plan shared core analyses and the required research and computing infrastructure to support the proposed research. They will also form the basis of assessment by the Project’s Access Review Committee, to permit access to data.
    [Show full text]
  • Features China Introduction
    Features China Introduction Tom Blundell (President, the Biochemical Society) This issue of The Biochemist is focused on biochemistry in China. It is timely because it reflects the history of biochemical research collaboration between Chinese and UK scientists, not only by looking back over the last century, but also by reviewing some of the strengths of biochemical research in China in 2011. Downloaded from http://portlandpress.com/biochemist/article-pdf/33/5/4/3914/bio033050004.pdf by guest on 27 September 2021 It has been a busy year for the Biochemical Society, which both in the UK and China. But there were interactions is celebrating its first century. It will do so at the Centenary before Needham became involved. In this issue, Randy Celebration event at the Royal Society in London in Poon draws our attention to one of these, the first paper December, but it has already done so very impressively in from China published in a journal of the Biochemical Shanghai in May with a Joint Sino–UK Protein Symposium. Society. In 1926 Ernest Tso of the Peking Union Medical There we heard about truly momentous contributions College described vitamins in preserved duck eggs, arising from interactions of influential scientists from maintaining they are “as much used on the table as is both China and UK during the last century. Just before cheese in Western countries”. the Symposium, also in May 2011, the Biochemical Journal We should also celebrate Wang Ying-Lai, who did his opened its China office in Beijing with a mini-symposium. PhD in Cambridge between 1938 and 1941.
    [Show full text]
  • Cambridge University Reporter Special Number 3
    2 OFFICERS NUMBER–MICHAELMAS TERM 2000 SPECIAL NO.3 PA RT I Chancellor: H.R.H. The Prince PHILIP, Duke of Edinburgh, T Vice-Chancellor: Prof. Sir Alec BROERS, CHU Deputy Vice-Chancellors: for –,A.M.LONSDALE, NH,O.S.O’NEILL, N,Q.R.D.SKINNER, CHR, D. E. NEWLAND, SE, Prof. D. H. MELLOR, DAR Pro-Vice-Chancellors: ,A.M.LONSDALE, NH, June , D. H. MELLOR, DAR, Dec. High Steward: Vacant Deputy High Steward: , The Rt Hon. Lord RICHARDSON, CAI Commissary: , The Rt Hon. Lord OLIVER, TH Proctors for ‒: F. H. KING, M Deputy: C. A. T. MALONE, NH R. J. STIBBS, DOW Deputy: S. A. T. REDFERN, JE Orator: ,A.J.BOWEN, JE Registrary: ,T.J.MEAD, W Deputy Registrary: ,N.J.B.A.BRANSON, DAR Secretary General of the Faculties: ,D.A.LIVESEY, EM Deputy Secretary General of the Faculties: ,G.P.ALLEN, W Librarian: ,P.K.FOX, SE Deputy Librarians: ,D.J.HALL, W , A. MURRAY, W Treasurer: ,J.M.WOMACK, TH Director of the Fitzwilliam Museum and Marlay Curator: ,D.D.ROBINSON, CL Development Director: Vacant Esquire Bedells: ,J.P.EMMINES, PET ,J.H.WILLIAMS, HH University Advocate: ,N.M.PADFIELD, F, Deputy University Advocate: ,P.J.ROGERSON, CAI, OFFICERS IN INSTITUTIONS PLACED UNDER THE SUPERVISION OF THE GENERAL BOARD PROFESSORS Aeronautical Engineering, Francis Mond W. N. D AWES, CHU Aerothermal Technology Vacant African History J. I LIFFE, JN American History, Paul Mellon A. J. BADGER, SID American History and Institutions, Pitt Vacant Anatomy W.A. HARRIS, CL Anaesthesia D. K. MENON Ancient History M.
    [Show full text]
  • Crystal Structures of Native and Inhibitedforms of Human Cathepsin
    Proc. Natl. Acad. Sci. USA Vol. 90, pp. 6796-6800, July 1993 Biochemustry Crystal structures of native and inhibited forms of human cathepsin D: Implications for lysosomal targeting and drug design (aspartic protcase/N-linked oligosaccharide/pepstatin A) ERic T. BALDWIN*, T. NARAYANA BHAT*, SERGEI GULNIK*, MADHUSOODAN V. HOSUR*t, RAYMOND C. SOWDER Il, RAUL E. CACHAU*, JACK COLLINS*, ABELARDO M. SILVA*, AND JOHN W. ERICKSON*§ *Structural Biochemistry Program, Frederick Biomedical Supercomputing Center and tAIDS Vaccine Program, Program Resources Inc./DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702 Communicated by David R. Davies, March 24, 1993 (receivedfor review February 4, 1993) ABSTRACT Cathepsin D (EC 3.4.23.5) is a lysosomal duced in the vicinity of the growing tumor, may degrade the protease suspected to play important roles in protein catabo- extracellular matrix and thereby promote the escape of lism, antigen processing, degenerative diseases, and breast cancer cells to the lymphatic and circulatory systems and cancer progresson. Determination of the crystal structures of enhance the invasion of new tissues (17, 18). The design of cathepsin D and a complex with pepstatin at 2.5 A resolution potent and specific inhibitors of cathepsin D will aid the provides insights into inhibitor binding and lysosomal targeting further elucidation of the roles of this enzyme in human for this two-chain, N-glycosylated aspartic protease. Compar- disease. We previously described the purification and crys- ison with the structures of a complex of pepstatin bound to tallization ofhuman cathepsin D from liver (3); similar studies rhizopuspepsin and with a human renin-bihbitor complex have been reported recently for cathepsin D isolated from revealed differences in subsite structures and inhibitor-enzyme bovine liver (19) and human spleen (20).
    [Show full text]
  • Part I Officers in Institutions Placed Under the Supervision of the General Board
    2 OFFICERS NUMBER–MICHAELMAS TERM 2009 [SPECIAL NO.7 PART I Chancellor: H.R.H. The Prince PHILIP, Duke of Edinburgh, T Vice-Chancellor: 2003, Prof. ALISON FETTES RICHARD, N, 2010 Deputy Vice-Chancellors for 2009–2010: Dame SANDRA DAWSON, SID,ATHENE DONALD, R,GORDON JOHNSON, W,STUART LAING, CC,DAVID DUNCAN ROBINSON, M,JEREMY KEITH MORRIS SANDERS, SE, SARAH LAETITIA SQUIRE, HH, the Pro-Vice-Chancellors Pro-Vice-Chancellors: 2004, ANDREW DAVID CLIFF, CHR, 31 Dec. 2009 2004, IAN MALCOLM LESLIE, CHR, 31 Dec. 2009 2008, JOHN MARTIN RALLISON, T, 30 Sept. 2011 2004, KATHARINE BRIDGET PRETTY, HO, 31 Dec. 2009 2009, STEPHEN JOHN YOUNG, EM, 31 July 2012 High Steward: 2001, Dame BRIDGET OGILVIE, G Deputy High Steward: 2009, ANNE MARY LONSDALE, NH Commissary: 2002, The Rt Hon. Lord MACKAY OF CLASHFERN, T Proctors for 2009–2010: JEREMY LLOYD CADDICK, EM LINDSAY ANNE YATES, JN Deputy Proctors for MARGARET ANN GUITE, G 2009–2010: PAUL DUNCAN BEATTIE, CC Orator: 2008, RUPERT THOMPSON, SE Registrary: 2007, JONATHAN WILLIAM NICHOLLS, EM Librarian: 2009, ANNE JARVIS, W Acting Deputy Librarian: 2009, SUSANNE MEHRER Director of the Fitzwilliam Museum and Marlay Curator: 2008, TIMOTHY FAULKNER POTTS, CL Director of Development and Alumni Relations: 2002, PETER LAWSON AGAR, SE Esquire Bedells: 2003, NICOLA HARDY, JE 2009, ROGER DERRICK GREEVES, CL University Advocate: 2004, PHILIPPA JANE ROGERSON, CAI, 2010 Deputy University Advocates: 2007, ROSAMUND ELLEN THORNTON, EM, 2010 2006, CHRISTOPHER FORBES FORSYTH, R, 2010 OFFICERS IN INSTITUTIONS PLACED UNDER THE SUPERVISION OF THE GENERAL BOARD PROFESSORS Accounting 2003 GEOFFREY MEEKS, DAR Active Tectonics 2002 JAMES ANTHONY JACKSON, Q Aeronautical Engineering, Francis Mond 1996 WILLIAM NICHOLAS DAWES, CHU Aerothermal Technology 2000 HOWARD PETER HODSON, G Algebra 2003 JAN SAXL, CAI Algebraic Geometry (2000) 2000 NICHOLAS IAN SHEPHERD-BARRON, T Algebraic Geometry (2001) 2001 PELHAM MARK HEDLEY WILSON, T American History, Paul Mellon 1992 ANTHONY JOHN BADGER, CL American History and Institutions, Pitt 2009 NANCY A.
    [Show full text]
  • Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The
    SUMMER 2014 ISSUE 27 encounters page 9 Science in the desert EMBO | EMBL Anniversary Science & Policy Meeting pageS 2 – 3 ANNIVERSARY TH page 8 Interview Jennifer E M B O 50 Lippincott-Schwartz H ©NI Membership expansion EMBO News New funding for senior postdoctoral In perspective Georgina Ferry’s enlarges its membership into evolution, researchers. EMBO Advanced Fellowships book tells the story of the growth and ecology and neurosciences on the offer an additional two years of financial expansion of EMBO since 1964. occasion of its 50th anniversary. support to former and current EMBO Fellows. PAGES 4 – 6 PAGE 11 PAGES 16 www.embo.org HIGHLIGHTS FROM THE EMBO|EMBL ANNIVERSARY SCIENCE AND POLICY MEETING transmissible cancer: the Tasmanian devil facial Science meets policy and politics tumour disease and the canine transmissible venereal tumour. After a ceremony to unveil the 2014 marks the 50th anniversary of EMBO, the 45th anniversary of the ScienceTree (see box), an oak tree planted in soil European Molecular Biology Conference (EMBC), the organization of obtained from countries throughout the European member states who fund EMBO, and the 40th anniversary of the European Union to symbolize the importance of European integration, representatives from the govern- Molecular Biology Laboratory (EMBL). EMBO, EMBC, and EMBL recently ments of France, Luxembourg, Malta, Spain combined their efforts to put together a joint event at the EMBL Advanced and Switzerland took part in a panel discussion Training Centre in Heidelberg, Germany, on 2 and 3 July 2014. The moderated by Marja Makarow, Vice President for Research of the Academy of Finland.
    [Show full text]
  • Iisc-Alumni Association- M.Vijayan Lecture. Cross Fertilisation: How
    IISc-Alumni Association- M.Vijayan Lecture. Cross Fertilisation: How Crystallography has built on Mathematics. Eleanor Dodson 17th August 2017 Nostalgia time: I cannot resist revisiting old photographs! Oxford 1968? Wedding Day – July 1969 DCH building first insulin model Vijayan lost in shadows? Oxford lab - 1969 Britishx5, Indian, NZ, Aust. David Phillips, Dorothy, Tony North, Thomas, Vijaya, Tom Blundell, Ted Baker, EJD Bangalore – 1970? Bangalore 1970s Kalyani, Vijayan, Tom Blundell -1975? Bangalore – 1979-80. Vijanan Davi Kalyani Bangalore 2007: Guy's 70th Birthday Cake Workshop 2008 DCH & Siv Ramasechan – 1965 our Anomalous Dispersion Guru First anomalous data measurements done in Oxford ~ 1960 on B12 derivative by K. Venkatesan Validation: More Thought Experiments: G.N. Ramachandran Mathematics in the Service of Science? Michael Mosley -BBC 2010 “Knowledge leaps forward when brilliant experiments are analysed by independent minds.” He was referring to the discovery that Mars moves in an elliptical orbit around the sun – established by Johannes Kepler -1599 using the observations of Tycho Brahe. Mathematics in the Service of Crystallography? Structure Solution exploits: Fundamental Mathematical concepts (Some elegant, but restricted to 3D for structure, and 2D for diffraction) Technical Mathematics and Computation (messy and very easy to get wrong!) Statistics (Much needed but messy too) Why crystallography? Quote: DCH: I also first learnt at the same time about biochemistry which provided me with the molecules it seemed most desirable to 'see'. …[The] great advantage of X-ray analysis as a method of chemical structure analysis is its power to show some totally unexpected and surprising structure and to do so with absolute certainty….
    [Show full text]
  • The Astbury Centre for Structural Molecular Biology Annual Report
    Front cover illustration Comparison of joint FRET efficiency and fluorescence lifetime histograms for closed SecYEG:SecA:ADP (left) and translocating complex in the presence of proSpy1 substrate and ATP (right). Top and right sides of each histogram show distribution of lifetimes and FRET efficiencies, respectively. This investigation was a collaboration between Roman Tuma, Joel Crossley, Matthew Watson, Sheena Radford (University of Leeds), and Ian Collinson, Dan Watkins (University of Bristol) and Tomas Fessl (University of South Bohemia).More details can be found on pg 93 of this report. i Mission Statement The Astbury Centre for Structural Molecular Biology will promote interdisciplinary research of the highest standard on the structure and function of biological molecules, biomolecular assemblies and complexes using physico-chemical, molecular biological and computational approaches. ii Introduction Welcome to the Annual Report of the Astbury Centre for Structural Molecular Biology 2018. I hope you enjoy reading its contents. It has been yet another busy and successful year for the Centre. The reports in the pages that follow highlight just some of our scientific successes of the last year of our members. We are proud of the strength of our community and our collaborations both locally within the Astbury Centre and University as well as with colleagues from across the globe. I would like to thank every member of the Centre for their hard work over the year: our Support staff, Technicians, Facility Managers, Students, Post-docs, Fellows and Academic staff and, of course, Lucy Gray for her excellent organisation and administrative support. Thank you all. During 2018 the Astbury Centre continued in its mission to “Understand Life in Molecular Detail” through multiple different activities, including some exciting research discoveries.
    [Show full text]
  • Women Physiologists
    Women physiologists: Centenary celebrations and beyond physiologists: celebrations Centenary Women Hodgkin Huxley House 30 Farringdon Lane London EC1R 3AW T +44 (0)20 7269 5718 www.physoc.org • journals.physoc.org Women physiologists: Centenary celebrations and beyond Edited by Susan Wray and Tilli Tansey Forewords by Dame Julia Higgins DBE FRS FREng and Baroness Susan Greenfield CBE HonFRCP Published in 2015 by The Physiological Society At Hodgkin Huxley House, 30 Farringdon Lane, London EC1R 3AW Copyright © 2015 The Physiological Society Foreword copyright © 2015 by Dame Julia Higgins Foreword copyright © 2015 by Baroness Susan Greenfield All rights reserved ISBN 978-0-9933410-0-7 Contents Foreword 6 Centenary celebrations Women in physiology: Centenary celebrations and beyond 8 The landscape for women 25 years on 12 "To dine with ladies smelling of dog"? A brief history of women and The Physiological Society 16 Obituaries Alison Brading (1939-2011) 34 Gertrude Falk (1925-2008) 37 Marianne Fillenz (1924-2012) 39 Olga Hudlická (1926-2014) 42 Shelagh Morrissey (1916-1990) 46 Anne Warner (1940–2012) 48 Maureen Young (1915-2013) 51 Women physiologists Frances Mary Ashcroft 56 Heidi de Wet 58 Susan D Brain 60 Aisah A Aubdool 62 Andrea H. Brand 64 Irene Miguel-Aliaga 66 Barbara Casadei 68 Svetlana Reilly 70 Shamshad Cockcroft 72 Kathryn Garner 74 Dame Kay Davies 76 Lisa Heather 78 Annette Dolphin 80 Claudia Bauer 82 Kim Dora 84 Pooneh Bagher 86 Maria Fitzgerald 88 Stephanie Koch 90 Abigail L. Fowden 92 Amanda Sferruzzi-Perri 94 Christine Holt 96 Paloma T. Gonzalez-Bellido 98 Anne King 100 Ilona Obara 102 Bridget Lumb 104 Emma C Hart 106 Margaret (Mandy) R MacLean 108 Kirsty Mair 110 Eleanor A.
    [Show full text]
  • Australian Biochemist the Magazine of the Australian Society for Biochemistry and Molecular Biology Inc
    ISSN 1443-0193 Australian Biochemist The Magazine of the Australian Society for Biochemistry and Molecular Biology Inc. Volume 47 AUGUST 2016 No.2 SHOWCASE ON RESEARCH Protein Misfolding and Proteostasis THIS ISSUE INCLUDES Showcase on Research Regular Departments A Short History of Amyloid SDS (Students) Page Molecular Chaperones: The Cutting Edge Guardians of the Proteome Off the Beaten Track When Proteostasis Goes Bad: Intellectual Property Protein Aggregation in the Cell Our Sustaining Members Extracellular Chaperones and Forthcoming Meetings Proteostasis Directory INSIDE ComBio2016 International Speaker Profiles Vol 47 No 2 August 2016 AUSTRALIAN BIOCHEMIST Page 1 ‘OSE’ Fill-in Puzzle We have another competition for the readers of the Australian Biochemist. All correct entries received by the Editor (email [email protected]) before 3 October 2016 will enter the draw to receive a gift voucher. With thanks to Rebecca Lew. The purpOSE is to choOSE from thOSE words listed and transpOSE them into the grid. So, clOSE your door, repOSE in a chair, and diagnOSE the answers – you don’t want to lOSE! 6 letters 8 letters ALDOSE FRUCTOSE FUCOSE FURANOSE HEXOSE PYRANOSE KETOSE RIBOSE 9 letters XYLOSE CELLULOSE GALACTOSE 7 letters RAFFINOSE AMYLOSE TREHALOSE GLUCOSE LACTOSE 11 letters MALTOSE DEOXYRIBOSE PENTOSE Australian Biochemist – Editor Chu Kong Liew, Editorial Officer Liana Friedman © 2016 Australian Society for Biochemistry and Molecular Biology Inc. All rights reserved. Page 2 AUSTRALIAN BIOCHEMIST Vol 47 No 2 August 2016 SHOWCASE ON RESEARCH EDITORIAL Molecular Origami: the Importance of Managing Protein Folding In my humble opinion, the most important biological transcription, RNA processing and transport, translation, molecule is the protein.
    [Show full text]
  • Annual Report 2004
    Astbury Centre for Structural Molecular Biology University of Leeds Annual Report 2004 © The University of Leeds, 2005 Front cover illustration: A collage of pictures illustrating the work of the Astbury Centre. Upper left: The contribution of the charge state ions to the folded (red), partially folded (yellow) and unfolded (green) β2-microglobulin conformers determined by ESI-Mass Spectrometry (see page 9); Upper right: Mechanical unfolding of proteins: a contour plot showing the difference in distance between every pair of amino-acids in protein L after pulling the protein apart by extensions of 1.6 Å before, and 1.6 Å after, the mechanical unfolding event. Pairs of residues that move further apart from each other during unfolding are coloured purple to green (-10 to 0Å), those that become closer to one another are shown in green to red (0 to 10 Å) (see page 23); Lower right: Dynamics on the ps-ns timescales for the backbone of apo-MS2W82R as detected by {1H} -15N Heteronculear nOe experiments. The image shows a tubes representation of the backbone of MS2W82R [PDB code 1MSC] with {1H}-15N heteronuclear nOe intensity shown by shading from white to black. White indicates little mobility [nOe ~ 0.8-0.9] and black indicates significant mobility [minimum nOe = 0.13] (see page 107); Lower left: Ribbon diagram of an AB coat protein dimer from the MS2 phage (subunit A in blue, B in green) complexed with the wild-type MS2 RNA stem-loop operator (shown in stick format) (see page 95). Acknowledgement The Astbury Centre for Structural Molecular Biology thanks its many sponsors for support of the work and its members for writing these reports.
    [Show full text]