DOCSLIB.ORG

The Astbury Centre for Structural Molecular Biology Annual Report

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
The Astbury Centre for Structural Molecular Biology Annual Report Front cover illustration Comparison of joint FRET efficiency and fluorescence lifetime histograms for closed SecYEG:SecA:ADP (left) and translocating complex in the presence of proSpy1 substrate and ATP (right). Top and right sides of each histogram show distribution of lifetimes and FRET efficiencies, respectively. This investigation was a collaboration between Roman Tuma, Joel Crossley, Matthew Watson, Sheena Radford (University of Leeds), and Ian Collinson, Dan Watkins (University of Bristol) and Tomas Fessl (University of South Bohemia).More details can be found on pg 93 of this report. i Mission Statement The Astbury Centre for Structural Molecular Biology will promote interdisciplinary research of the highest standard on the structure and function of biological molecules, biomolecular assemblies and complexes using physico-chemical, molecular biological and computational approaches. ii Introduction Welcome to the Annual Report of the Astbury Centre for Structural Molecular Biology 2018. I hope you enjoy reading its contents. It has been yet another busy and successful year for the Centre. The reports in the pages that follow highlight just some of our scientific successes of the last year of our members. We are proud of the strength of our community and our collaborations both locally within the Astbury Centre and University as well as with colleagues from across the globe. I would like to thank every member of the Centre for their hard work over the year: our Support staff, Technicians, Facility Managers, Students, Post-docs, Fellows and Academic staff and, of course, Lucy Gray for her excellent organisation and administrative support. Thank you all. During 2018 the Astbury Centre continued in its mission to “Understand Life in Molecular Detail” through multiple different activities, including some exciting research discoveries. We continued to enjoy an excellent seminar series (organised by Joe Cockburn), hosting 9 lectures during the year with speakers from the UK and Europe. An inspiring twelfth Annual Astbury Lecture was given by Prof Rick Morimoto, (Northwestern University, Illinois) on the 19th June, entitled “Protein Quality Control and Cell Stress Responses to Protect Cellular Health in Aging and Disease". This annual event was followed by our tradition of a highly competitive sports day and barbecue hosted by the Astbury Society (see http://www.astbury.leeds.ac.uk/about/society.php). On 20th September, 168 members attended the Centre’s Biennial Research Away Day held at Headingly Stadium for the first time. The day was a fantastic success and students, post-docs and PIs shared their recent exciting scientific discoveries, through talks, posters and the ever-popular “Flash Poster” presentations. Poster prizes were awarded to Jack Caudwell and Ashley Hancock for the best posters. Well done all! We look forward now to events during 2019, with our 20th birthday and residential retreat in a new location- watch out for an update on these events in the coming months and in next year’s report. The 2018 VC Jordan/PR Radford Prize for the best PhD thesis in the Astbury Centre was awarded to Craig Wilkinson for his thesis “Investigating the catalytic cycle of membrane-bound pyrophosphatases (M-PPases).” performed in Professor Adrian Goldman’s laboratory. This annual prize was established in 2017 by a generous donation from Leeds University alumnus Professor Craig Jordan and was presented to Craig by Sir Alan Langmands, Vice Chancellor of the University at the Annual Lecture, http://www.astbury.leeds.ac.uk/prize/. The Centre welcomed five new PI members in 2018: Rene Frank, Qian Wu, Takashi Ochi, Christos Pliotas (University Academic Fellows) and Yuan Guo (University Lecturer in the School of Food Science). Five research fellows also joined the Centre: Elisabetta Gropelli, Nikesh Patel, Vajinder Kumar, Akshath Uchangi and Jenny Tomlinson (see http://www.astbury.leeds.ac.uk/people/external_fellows.php). We look forward to their involvement in Astbury Centre activities. We were also delighted to welcome our new PhD students and postdocs to the Centre this year, bringing our total number of researchers to >400, including 76 academic staff, 261 PhD students, 99 postdoctoral researchers and 14 Research Fellows. Astbury Centre members published their research in a wide range of journals in 2018 including Nature Communications, Nature, JACS and Science. A full list can be found at the end of this report. In terms of grant income, Astbury members also enjoyed many successes in 2018. £14M of new project and programme grants brings the Astbury grant portfolio to a striking £69M share of £111.7M of grants: an impressive figure that is testament to the hard work and success of our members. We are much indebted to the funding agencies that support our science, including BBSRC, EPSRC, MRC, the Wellcome Trust, charities, ERC, EU and Industry. We also acknowledge, with thanks, the support of the University of Leeds; the Faculties of Biological Sciences, Maths and Physical Sciences and Medicine and Health, and the Schools of Chemistry, Molecular and Cellular Biology, Biomedical Sciences and Physics and Astronomy for their support of the Centre and our research. iii There was continued success in 2018 for members of the Astbury Centre in terms of peer recognition. Adam Nelson was awarded the European Federation for Medicinal Chemistry’s 2018 UCB-Ehrlich Award for Excellence in Medicinal Chemistry. The award recognises his implementation of a vision for new chemical synthesis methods to align with drug discovery needs. Our PhD students won a variety of prizes and awards in 2018. Jack Caudwell (Turnbull & Evans group) won a poster prize at the Leeds Microbubble symposium and also won the School of Chemistry postgraduate conference poster conference prize. Emma Cawood (Wilson group) won first prize for her poster at the RSC Chemical Biology and Bioorganic Group Postgraduate Meeting. Kristina Parashiv (Wilson group) won second prize for her poster at the RSC Chemical Biology and Bioorganic Group Postgraduate Meeting. Zsofia Hegedus (Wilson group) won a poster prize at the RSC Peptides and Protein Group Early Stage Research Meeting. Rachel Johnson (Muench group) won a poster prize at the Toronto ACA meeting. Congratulations also go to Ethan Morgan (Macdonald group) who was awarded a WT ISSF award to begin the transition to independent researcher. This funds him for one year to work on his own strand of research, whilst based in the laboratory. Well done all on your wonderful achievements. The Astbury Centre continued to contribute to public engagement events in 2018 with a significant presence at the ‘Be Curious’ event in March, ‘Light Night Leeds’ event in October and the ‘One Day At Leeds’ event in November. We are currently looking forward to the third Astbury Conversation that will be held at the University of Leeds on 23rd & 24th March 2020 on the topic ‘Seeing into Cells’ (see https://astburyconversation.leeds.ac.uk). Registration opens in Spring 2019. Do register and join us for a fantastic two days of cutting edge science. The Astbury Society, led by the presidents David Nicholson and Georgia Pangratiou, played a fantastic role in Astbury activities in 2018. Events included the famous Christmas quiz night, wine and cheese events, and a hugely successful sixth May Ball. With continued fund raising through cake bakes and coffee mornings, the Society continues to support the “Leeds Children’s Charity” with donations reaching an impressive £5127 to date. See http://www.astbury.leeds.ac.uk/about/society.php for photos of these events. I hope that you enjoy reading this Annual Report. Thank you to David Brockwell and Lucy Gray for editing this report, everyone who contributed to it, and all who participated in the Astbury Centre’s activities in 2018. The Astbury Centre will celebrate its 20th year in 2019 and we look forward to celebrating this momentous occasion and to continuing our successes in the year ahead. Sheena E. Radford, FMedSci, FRS Director, Astbury Centre for Structural Molecular Biology, Leeds, February 2019 Please note that this report (as well as those from previous years) is also available as a PDF document which can be downloaded from our website (www.astbury.leeds.ac.uk). iv CONTENTS Pages Understanding the role of light-harvesting proteins in photo-protection and 1-2 their manipulation for artificial photosynthesis Ashley Hancock and Peter Adams Peroxisome biogenesis and function 3-4 Jack Wright, Sophie Moul, Yousef Al Hajaya, Adrian Goldman, Stephen Muench, Stuart Warriner and Alison Baker The structural mechanisms that underpin the regulation of proteins by 5-6 phosphorylation Selena Burgess, Manjeet Mukherjee, Mark Richards, Sarah Sabir, Josephina Sampson and Richard Bayliss The interaction of silver nanoparticles with model membranes 7-8 Marcos Arribas Perez and Paul Beales Engineering novel natural products and binding motifs 9-10 Ieva Drulyte, Daniel Van, Emily Turri, Adam Nelson and Alan Berry Selective TRPC5 channel activation with a xanthine derivative 11 Aisling Minard, Claudia Bauer, Stuart Warriner, Robin Bon Recognition of disease mutants of FGFR3 by the Cdc37 co-chaperone 12-13 Brendan Farrell and Alex Breeze Kinesin-1: Molecular mechanisms of cargo binding and regulation of transport 14 Sophie Hesketh, Peter Mulhair, Maren Thomsen, Mary O’Connell and Joe Cockburn Water clustering drives temperature-dependent segregation in alcohol-water 15-16 mixtures Samuel Lenton, Natasha Rhys, James Towey and Lorna
Load more

Recommended publications
  • Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The
    SUMMER 2014 ISSUE 27 encounters page 9 Science in the desert EMBO | EMBL Anniversary Science & Policy Meeting pageS 2 – 3 ANNIVERSARY TH page 8 Interview Jennifer E M B O 50 Lippincott-Schwartz H ©NI Membership expansion EMBO News New funding for senior postdoctoral In perspective Georgina Ferry’s enlarges its membership into evolution, researchers. EMBO Advanced Fellowships book tells the story of the growth and ecology and neurosciences on the offer an additional two years of financial expansion of EMBO since 1964. occasion of its 50th anniversary. support to former and current EMBO Fellows. PAGES 4 – 6 PAGE 11 PAGES 16 www.embo.org HIGHLIGHTS FROM THE EMBO|EMBL ANNIVERSARY SCIENCE AND POLICY MEETING transmissible cancer: the Tasmanian devil facial Science meets policy and politics tumour disease and the canine transmissible venereal tumour. After a ceremony to unveil the 2014 marks the 50th anniversary of EMBO, the 45th anniversary of the ScienceTree (see box), an oak tree planted in soil European Molecular Biology Conference (EMBC), the organization of obtained from countries throughout the European member states who fund EMBO, and the 40th anniversary of the European Union to symbolize the importance of European integration, representatives from the govern- Molecular Biology Laboratory (EMBL). EMBO, EMBC, and EMBL recently ments of France, Luxembourg, Malta, Spain combined their efforts to put together a joint event at the EMBL Advanced and Switzerland took part in a panel discussion Training Centre in Heidelberg, Germany, on 2 and 3 July 2014. The moderated by Marja Makarow, Vice President for Research of the Academy of Finland.
    [Show full text]
  • Women Physiologists
    Women physiologists: Centenary celebrations and beyond physiologists: celebrations Centenary Women Hodgkin Huxley House 30 Farringdon Lane London EC1R 3AW T +44 (0)20 7269 5718 www.physoc.org • journals.physoc.org Women physiologists: Centenary celebrations and beyond Edited by Susan Wray and Tilli Tansey Forewords by Dame Julia Higgins DBE FRS FREng and Baroness Susan Greenfield CBE HonFRCP Published in 2015 by The Physiological Society At Hodgkin Huxley House, 30 Farringdon Lane, London EC1R 3AW Copyright © 2015 The Physiological Society Foreword copyright © 2015 by Dame Julia Higgins Foreword copyright © 2015 by Baroness Susan Greenfield All rights reserved ISBN 978-0-9933410-0-7 Contents Foreword 6 Centenary celebrations Women in physiology: Centenary celebrations and beyond 8 The landscape for women 25 years on 12 "To dine with ladies smelling of dog"? A brief history of women and The Physiological Society 16 Obituaries Alison Brading (1939-2011) 34 Gertrude Falk (1925-2008) 37 Marianne Fillenz (1924-2012) 39 Olga Hudlická (1926-2014) 42 Shelagh Morrissey (1916-1990) 46 Anne Warner (1940–2012) 48 Maureen Young (1915-2013) 51 Women physiologists Frances Mary Ashcroft 56 Heidi de Wet 58 Susan D Brain 60 Aisah A Aubdool 62 Andrea H. Brand 64 Irene Miguel-Aliaga 66 Barbara Casadei 68 Svetlana Reilly 70 Shamshad Cockcroft 72 Kathryn Garner 74 Dame Kay Davies 76 Lisa Heather 78 Annette Dolphin 80 Claudia Bauer 82 Kim Dora 84 Pooneh Bagher 86 Maria Fitzgerald 88 Stephanie Koch 90 Abigail L. Fowden 92 Amanda Sferruzzi-Perri 94 Christine Holt 96 Paloma T. Gonzalez-Bellido 98 Anne King 100 Ilona Obara 102 Bridget Lumb 104 Emma C Hart 106 Margaret (Mandy) R MacLean 108 Kirsty Mair 110 Eleanor A.
    [Show full text]
  • Australian Biochemist the Magazine of the Australian Society for Biochemistry and Molecular Biology Inc
    ISSN 1443-0193 Australian Biochemist The Magazine of the Australian Society for Biochemistry and Molecular Biology Inc. Volume 47 AUGUST 2016 No.2 SHOWCASE ON RESEARCH Protein Misfolding and Proteostasis THIS ISSUE INCLUDES Showcase on Research Regular Departments A Short History of Amyloid SDS (Students) Page Molecular Chaperones: The Cutting Edge Guardians of the Proteome Off the Beaten Track When Proteostasis Goes Bad: Intellectual Property Protein Aggregation in the Cell Our Sustaining Members Extracellular Chaperones and Forthcoming Meetings Proteostasis Directory INSIDE ComBio2016 International Speaker Profiles Vol 47 No 2 August 2016 AUSTRALIAN BIOCHEMIST Page 1 ‘OSE’ Fill-in Puzzle We have another competition for the readers of the Australian Biochemist. All correct entries received by the Editor (email [email protected]) before 3 October 2016 will enter the draw to receive a gift voucher. With thanks to Rebecca Lew. The purpOSE is to choOSE from thOSE words listed and transpOSE them into the grid. So, clOSE your door, repOSE in a chair, and diagnOSE the answers – you don’t want to lOSE! 6 letters 8 letters ALDOSE FRUCTOSE FUCOSE FURANOSE HEXOSE PYRANOSE KETOSE RIBOSE 9 letters XYLOSE CELLULOSE GALACTOSE 7 letters RAFFINOSE AMYLOSE TREHALOSE GLUCOSE LACTOSE 11 letters MALTOSE DEOXYRIBOSE PENTOSE Australian Biochemist – Editor Chu Kong Liew, Editorial Officer Liana Friedman © 2016 Australian Society for Biochemistry and Molecular Biology Inc. All rights reserved. Page 2 AUSTRALIAN BIOCHEMIST Vol 47 No 2 August 2016 SHOWCASE ON RESEARCH EDITORIAL Molecular Origami: the Importance of Managing Protein Folding In my humble opinion, the most important biological transcription, RNA processing and transport, translation, molecule is the protein.
    [Show full text]
  • Annual Report 2004
    Astbury Centre for Structural Molecular Biology University of Leeds Annual Report 2004 © The University of Leeds, 2005 Front cover illustration: A collage of pictures illustrating the work of the Astbury Centre. Upper left: The contribution of the charge state ions to the folded (red), partially folded (yellow) and unfolded (green) β2-microglobulin conformers determined by ESI-Mass Spectrometry (see page 9); Upper right: Mechanical unfolding of proteins: a contour plot showing the difference in distance between every pair of amino-acids in protein L after pulling the protein apart by extensions of 1.6 Å before, and 1.6 Å after, the mechanical unfolding event. Pairs of residues that move further apart from each other during unfolding are coloured purple to green (-10 to 0Å), those that become closer to one another are shown in green to red (0 to 10 Å) (see page 23); Lower right: Dynamics on the ps-ns timescales for the backbone of apo-MS2W82R as detected by {1H} -15N Heteronculear nOe experiments. The image shows a tubes representation of the backbone of MS2W82R [PDB code 1MSC] with {1H}-15N heteronuclear nOe intensity shown by shading from white to black. White indicates little mobility [nOe ~ 0.8-0.9] and black indicates significant mobility [minimum nOe = 0.13] (see page 107); Lower left: Ribbon diagram of an AB coat protein dimer from the MS2 phage (subunit A in blue, B in green) complexed with the wild-type MS2 RNA stem-loop operator (shown in stick format) (see page 95). Acknowledgement The Astbury Centre for Structural Molecular Biology thanks its many sponsors for support of the work and its members for writing these reports.
    [Show full text]
  • BIOLOGY 639 SCIENCE ONLINE the Unexpected Brains Behind Blood Vessel Growth 641 THIS WEEK in SCIENCE 668 U.K
    4 February 2005 Vol. 307 No. 5710 Pages 629–796 $10 07%.'+%#%+& 2416'+0(70%6+10 37#06+6#6+8' 51(69#4' #/2.+(+%#6+10 %'..$+1.1); %.10+0) /+%41#44#;5 #0#.;5+5 #0#.;5+5 2%4 51.76+105 Finish first with a superior species. 50% faster real-time results with FullVelocity™ QPCR Kits! Our FullVelocity™ master mixes use a novel enzyme species to deliver Superior Performance vs. Taq -Based Reagents FullVelocity™ Taq -Based real-time results faster than conventional reagents. With a simple change Reagent Kits Reagent Kits Enzyme species High-speed Thermus to the thermal profile on your existing real-time PCR system, the archaeal Fast time to results FullVelocity technology provides you high-speed amplification without Enzyme thermostability dUTP incorporation requiring any special equipment or re-optimization. SYBR® Green tolerance Price per reaction $$$ • Fast, economical • Efficient, specific and • Probe and SYBR® results sensitive Green chemistries Need More Information? Give Us A Call: Ask Us About These Great Products: Stratagene USA and Canada Stratagene Europe FullVelocity™ QPCR Master Mix* 600561 Order: (800) 424-5444 x3 Order: 00800-7000-7000 FullVelocity™ QRT-PCR Master Mix* 600562 Technical Services: (800) 894-1304 Technical Services: 00800-7400-7400 FullVelocity™ SYBR® Green QPCR Master Mix 600581 FullVelocity™ SYBR® Green QRT-PCR Master Mix 600582 Stratagene Japan K.K. *U.S. Patent Nos. 6,528,254, 6,548,250, and patents pending. Order: 03-5159-2060 Purchase of these products is accompanied by a license to use them in the Polymerase Chain Reaction (PCR) Technical Services: 03-5159-2070 process in conjunction with a thermal cycler whose use in the automated performance of the PCR process is YYYUVTCVCIGPGEQO covered by the up-front license fee, either by payment to Applied Biosystems or as purchased, i.e., an authorized thermal cycler.
    [Show full text]
  • Issue 3 (November) 2014
    ISSUE 3 (NOVEMBER) 2014 40th FEBS Congress FEBS programmes: FEBS–EMBO 2014 FEBS publications FEBS community updates conference round-up news Page 4 Page 8 Page 12 Page 26 Page 35 CONTENTS Contents: Key upcoming dates for Preface 3 FEBS activities FEBS Programmes: updates 40th FEBS Congress 40th FEBS Congress, Berlin, 2015 4 4–9 July 2015 FEBS Advanced Courses 8 Abstract submission deadline: 2 March 2015 FEBS Education Activities 11 Bursary application deadline: 2 March 2015 Early-bird registration deadline: 12 March 2015 FEBS–EMBO 2014 Conference Round-up www.febs2015.org The FEBS–EMBO 2014 Conference 12 FEBS Awards 14 FEBS Young Scientists’ Forum FEBS Workshops and Events 17 2–4 July 2014 FEBS Young Scientists’ Forum 2014 22 Application deadline: 31 January 2015 bit.ly/YSF2015 FEBS Fellows Meeting 2014 24 FEBS 50th Anniversary Dinner 25 FEBS Advanced Courses Applications for 2016 course funding: 1 March 2015 FEBS Publications Applications to participate in 2015 courses: see FEBS Publications at FEBS–EMBO 2014 26 individual course deadlines Digital Developments 28 www.febs.org/our-activities/advanced- Journal Highlights and Special Issues 33 courses/2015-advanced-courses FEBS Community News FEBS – Biochemical Society FEBS-sponsored Lectures 35 Education Workshop Obituary 38 FEBS Education Workshop bursaries deadline: FEBS Council: Elections 39 1 December 2014 Abstract submission deadline: 26 January 2015 Scientific Events Calendar 40 www.febs.org/our-activities/education Cover: Berlin, at the heart of the FEBS area, is the location for the 2015 FEBS Congress, hosted this time by the German Society for Biochemistry and Molecular Biology. Registration and abstract submission for the Congress have opened, and the event is introduced on pages 4–7 of this issue of FEBS News.
    [Show full text]
  • Communicating Biochemistry: Meetings and Events
    © The Authors. Volume compilation © 2011 Portland Press Limited Chapter 3 Communicating Biochemistry: Meetings and Events Ian Dransfield and Brian Beechey Scientific conferences organized by the Biochemical Society represent a key facet of activity throughout the Society’s history and remain central to the present mission of promoting the advancement of molecular biosciences. Importantly, scientific conferences are an important means of communicating research findings, establishing collaborations and, critically, a means of cementing the community of biochemical scientists together. However, in the past 25 years, we have seen major changes to the way in which science is communicated and also in the way that scientists interact and establish collabo- rations. For example, the ability to show videos, “fly through” molecular structures or show time-lapse or real-time movies of molecular events within cells has had a very positive impact on conveying difficult concepts in presentations. However, increased pressures on researchers to obtain/maintain funding can mean that there is a general reluctance to present novel, unpublished data. In addition, the development of email and electronic access to scientific journals has dramatically altered the potential for communi- cation and accessibility of information, perhaps reducing the necessity of attending meetings to make new contacts and to hear exciting new science. The Biochemical Society has responded to these challenges by progressive development of the meetings format to better match the
    [Show full text]
  • Structural Insights Into Peptide Self‐Assembly Using Photo‐Induced Crosslinking Experiments and Discontinuous Molecular Dyna
    Received: 15 July 2020 Revised: 7 October 2020 DOI: 10.1002/aic.17101 THERMODYNAMICS AND MOLECULAR-SCALE PHENOMENA Structural insights into peptide self-assembly using photo-induced crosslinking experiments and discontinuous molecular dynamics Samuel J. Bunce1,2 | Yiming Wang3,4 | Sheena E. Radford2,5 | Andrew J. Wilson1,2 | Carol K. Hall3 1School of Chemistry, University of Leeds, Leeds, UK Abstract 2Astbury Centre for Structural Molecular Determining the structure of the (oligomeric) intermediates that form during the Biology, University of Leeds, Leeds, UK self-assembly of amyloidogenic peptides is challenging because of their heteroge- 3Department of Chemical and Biomolecular Engineering, North Carolina State University, neous and dynamic nature. Thus, there is need for methodology to analyze the Raleigh, North Carolina underlying molecular structure of these transient species. In this work, a combination 4 Department of Chemical and Biological of fluorescence quenching, photo-induced crosslinking (PIC) and molecular dynamics Engineering, Princeton University, Princeton, New Jersey simulation was used to study the assembly of a synthetic amyloid-forming peptide, 5 School of Molecular and Cellular Biology, Aβ16-22. A PIC amino acid containing a trifluormethyldiazirine (TFMD) group—Fmoc University of Leeds, Leeds, UK (TFMD)Phe—was incorporated into the sequence (Aβ*16–22). Electrospray ionization Correspondence ion-mobility spectrometry mass-spectrometry (ESI-IMS-MS) analysis of the PIC prod- Carol K. Hall, Department of Chemical and ucts confirmed that Aβ* – forms assemblies with the monomers arranged as anti- Biomolecular Engineering, North Carolina 16 22 State University, Raleigh, NC 27695-7905. parallel, in-register β-strands at all time points during the aggregation assay.
    [Show full text]
  • Programme Spring 2019
    Chairman: Secretary: Treasurer: Professor Simon Duckett CChem FRSC Dr Stephen Byard CChem FRSC Dr John Parkinson CChem FRSC Department of Chemistry Head of Molecule Development and Department of Pure & Applied Chemistry University of York, Scientific Direction University of Strathclyde Heslington, ARCINOVA Thomas Graham Building York, Taylor Drive 295 Cathedral Street, YO10 5DD Alnwick Glasgow G1 1XL Tel: +44 (0) 1904 322564 Northumberland NE66 2DH Tel: +44 (0) 141 5482820 Email: [email protected] Tel: +44 (0) 1665 608544 Fax: +44 (0) 141 5484822 Email: [email protected] Email: [email protected] An Interest Group of the Royal Society of Chemistry Charity Registration No. 207890 NMR in Biophysics and Molecular Biology Date of meeting: Wednesday 10th - Thursday 11th April 2019 Meeting venue: Conference Auditorium 2 University of Leeds, Woodhouse Lane, Leeds, LS2 9JT Dear NMR Spectroscopist, One of the principal objectives of the NMR Discussion Group is to provide mechanisms for educating, sharing ideas and promoting recent developments in NMR and related disciplines. The group continues to provide such opportunities for scientists that work in many different areas associated with magnetic resonance. On this occasion, we are delighted to be hosting a joint two-day event in conjunction with the British Biophysical Society, facilitating exchange of information from cutting-edge research activities in Biophysics and Molecular Biology. There will also be opportunities to present posters and meet informally with other research workers. In particular, early career research workers are encouraged to attend the event, and bursaries will be made available to those who submit an abstract which is accepted for either a poster or short oral presentation.
    [Show full text]
  • First Ron Hites Award Goes to Alison E. Ashcroft, Sheena Radford, and Coauthors
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector EDITORIAL First Ron Hites Award goes to Alison E. Ashcroft, Sheena Radford, and Coauthors e are pleased to announce the first Ron Hites Award to Alison E. Ashcroft, Sheena Rad- Wford, and their coauthors for their paper, “Monitoring Co-populated Conformational States during Protein Folding Events Using Electrospray Ionization-Ion Mobility Spectrometry-Mass Spectrometry” by David P. Smith, Kevin Giles, Robert H. Bateman, Sheena E. Rad- ford, and Alison E. Ashcroft, J. Am. Soc. Mass Spectrom., 2007, 18, 2180–2190. “The Ron Hites Award recognizes a high quality presentation of outstanding original research. Selection is based on a paper’s innovative aspects, technical quality, likely stimulation of future research, likely impact on future applications, and quality of presentation. The Award is named in honor of Professor Ronald A. Hites of Indiana University, who led the creation of JASMS in 1988 while president of ASMS.” (from the 2009 ASMS Conference Program). The award was announced in an editorial by ASMS president, Gary Glish, JASMS, No- vember 2008, 19, 1577. Alison Ashcroft is Professor of Biomolecular Mass Spectrometry in the Astbury Centre for Structural Mo- lecular Biology and the Faculty of Biological Sciences at the University of Leeds, UK. After post-doctoral re- search at the University of Geneva, Switzerland, Ash- croft went into industry (Kratos Analytical, AstraZeneca, Micromass/Waters) before joining the University of Leeds in 1997. Her research is focused on the applica- tion and development of mass spectrometry for study- Colworth Medal and the Astra-Zeneca prize for Protein ing protein folding and protein conformer characteriz- and Peptide Research and was elected a member of ation, biomolecular assembly pathways, and protein EMBO.
    [Show full text]
  • Protein Folding and Dynamics at NCBS, Bengaluru
    The Third International Symposium on Protein Folding and Dynamics at NCBS, Bengaluru ORGANIZERS CONFIRMED SPEAKERS Jayant B. Udgaonkar Douglas Barrick Johns Hopkins University, USA NCBS, Bengaluru Paula Booth King’s College London, UK Patricia Clark Notre Dame University, USA C. Robert Matthews Jane Clarke University of Cambridge, UK University of Massachusetts, USA Lila Gierasch University of Massachusetts, USA Shachi Gosavi NCBS, Bengaluru Yuji Goto Osaka University, Japan Gilad Haran Weizmann Institute of Science, Israel Michael Harms University of Oregon, USA Hagen Hofmann Weizmann Institute of Science, Israel Gerhard Hummer Max Planck Institute of Biophysics, Germany th th Thomas Kiefhaber University of Halle, Germany 8 -11 Jooyoung Lee KIAS, South Korea R. Mahalakshmi IISER, Bhopal Samrat Mukhopadhyay IISER, Mohali November, 2016 Sudipta Maiti TIFR, Mumbai Athi Naganathan IIT, Madras NCBS, Bengaluru Rohit Pappu Washington University, USA Sheena Radford University of Leeds, UK Govardhan Reddy IISc , Bengaluru Catherine Royer Rensselaer Polytechnic Institute, USA Registration deadline Tobin Sosnick University of Chicago, USA Hideki Taguchi Tokyo Institute of Technology, Japan July 1, 2016 Tahei Tahara RIKEN, Japan Satoshi Takahashi Tohoku University, Japan Michael Woodside University of Alberta, Canada Tae-Young Yoon KAIST, South Korea The symposium will consist of talks by students and postdoctoral fellows, discussions led by faculty members but driven by students, poster sessions, as well as talks by leaders in the of Protein Folding and Dynamics . For more information and to apply visit National Centre for Biological Sciences https://events.ncbs.res.in/event/third-international- Tata Institute of Fundamental Research symposium-protein-folding-and-dynamics GKVK, Bellary Road, Bengaluru -560065 THIRD INTERNATIONAL PROTEIN FOLDING Sponsors SYMPOSIUM THIRD INTERNATIONAL PROTEIN FOLDING Sponsors SYMPOSIUM Daily THIRD INTERNATIONAL PROTEIN Schedule FOLDING SYMPOSIUM Tuesday, November 8, 2016 08:00 – 08:45 Registration 08:45 – 09:00 Welcome by Jayant B.
    [Show full text]
  • It Is with Great Pleasure That I Write This, My First
    Front cover illustration: The development of ‘activity directed synthesis’ by the Nelson and Warriner groups. Its application to the discovery of novel small molecule scaffolds with agonist activity against the androgen receptor was published in Nature Chemistry and is described on pages 57-58. Acknowledgement The Astbury Centre for Structural Molecular Biology thanks its many sponsors for support of the work and its members for writing these reports. The report is edited by David Brockwell. This report is also available electronically via http://www.astbury.leeds.ac.uk i Mission Statement The Astbury Centre for Structural Molecular Biology will promote interdisciplinary research of the highest standard on the structure and function of biological molecules, biomolecular assemblies and complexes using physico-chemical, molecular biological and computational approaches. ii Introduction Another year has passed by very quickly and it does not seem long since I was writing the Introduction to last years’ Astbury Annual Report! 2014 proved to be another busy and successful year for the Centre, as this letter and the scientific reports that follow portray. In the following pages you will find new and exciting research which spans fundamental research in Structural Molecular Biology, Biophysics, Chemical Biology and Cell Biology, alongside the exploitation of the results obtained in biotechnology, bioengineering and medicine, each made possible by the inter- and multidisciplinary research within the Centre. I would like to thank every member of the Centre for their hard work over the year: our Support staff, Technicians, Facility Managers, Students, Post-docs, Fellows and Academic staff. Our success comes from our strong multidisciplinary science, as well as our collegiality and teamwork.
    [Show full text]