Chemical and Biological Defense Program Annual Report to Congress, March 2000
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The Science of the Bioeconomy
The science of the Bioeconomy Dr. Henrike Gebhardt 05 December 2014 Our positioning Evonik is the creative industrial group from Germany and one of the world’s leading specialty chemicals companies. The Science of the Bioeconomy Page 3 Our credo The Bioeconomy is one driver to promote a more resource-efficient and sustainable economy. Industrial biotechnology is a key technology for realising the bioeconomy. The Science of the Bioeconomy Page 5 Overview Bioeconomy Biotechnology Genetic engineering The Science of the Bioeconomy Page 6 Definitions Bioeconomy Production of renewable biological resources and the conversion of these resources and waste streams into value added products, such as food, feed, and other industrial products and energy. COM(2012) 60, EU Commission, mod. Bio-basedBiotechnology products ProductsThe use whollyof living or organisms partly derived or their from components biomass. EN to16575 make products. Genetic engineering Any of various applications of biological science used in the manipulation of the genome of an organism The Science of the Bioeconomy Page 7 Bio-based products offered by Evonik Polyamids Polyesters VESTAMID ®Terra DYNACOLL ®Terra DYNAPOL ®Terra VISIOMER ®Terra Additives Amino acids Cosmetics BioMTBE Feed additives Health – purified TEGOSOFT ®MM bio-based AdditivesCleaning Health VISCOPLEX ® Series 10 Esterquats RESOMER ® bio- degradable The Science of the Bioeconomy Page 8 Evonik invests in high-growth chemical megatrends Lighthouse investment projects Lysine Russia Consumer Specialties China C4 Chemistry H O / HPPO Europe 2 2 Lysine Expansion China USA Crosslinkers, Isophorone China Consumer Specialties Superabsorbents Brazil Saudi Arabia Methionine Singapore Biodiesel catalysts Argentina Bioeconomy Lysine Traditional Brazil The Science of the Bioeconomy Page 9 Bioeconomy Press releases Company Raw Intermediate Product Material Date of Issue Volume Commissioning DSM/POET (USA) Cellulosics Ethanol Biofuels from corn Jan 2012 90 kta H1.2014 cobs Purac/BASF (ES) Cellulosics Succinic acid e. -
International Handbook of Foodborne Pathogens
INTERNATIONAL HANDBOOK OF FOODBORNE PATHOGENS EDITED BY MARIANNE D. MILIOTIS U.S. Food and Drug Administration College Park, Maryland, U.S.A. JEFFREY W. BIER Food Safety Consultant Alexandria, Virginia, U.S.A. MARCEL H MARCEL DEKKER, INC. NEW YORK • BASEL Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress. ISBN: 0-8247-0685-4 This book is printed on acid-free paper. Headquarters Marcel Dekker, Inc. 270 Madison Avenue, New York, NY 10016 tel: 212-696-9000; fax: 212-685-4540 Eastern Hemisphere Distribution Marcel Dekker AG Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 41-61-260-6300; fax: 41-61-260-6333 World Wide Web http://www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Current printing (last digit): 10987654321 PRINTED IN THE UNITED STATES OF AMERICA Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. FOOD SCIENCE AND TECHNOLOGY A Series of Monographs, Textbooks, and Reference Books EDITORIAL BOARD Senior Editors Owen R. Fennema University of Wisconsin-Madison Y. H. Hui Science Technology System Marcus Karel Rutgers University (emeritus) Pieter Walstra Wagenmgen University John R. -
Zerohack Zer0pwn Youranonnews Yevgeniy Anikin Yes Men
Zerohack Zer0Pwn YourAnonNews Yevgeniy Anikin Yes Men YamaTough Xtreme x-Leader xenu xen0nymous www.oem.com.mx www.nytimes.com/pages/world/asia/index.html www.informador.com.mx www.futuregov.asia www.cronica.com.mx www.asiapacificsecuritymagazine.com Worm Wolfy Withdrawal* WillyFoReal Wikileaks IRC 88.80.16.13/9999 IRC Channel WikiLeaks WiiSpellWhy whitekidney Wells Fargo weed WallRoad w0rmware Vulnerability Vladislav Khorokhorin Visa Inc. Virus Virgin Islands "Viewpointe Archive Services, LLC" Versability Verizon Venezuela Vegas Vatican City USB US Trust US Bankcorp Uruguay Uran0n unusedcrayon United Kingdom UnicormCr3w unfittoprint unelected.org UndisclosedAnon Ukraine UGNazi ua_musti_1905 U.S. Bankcorp TYLER Turkey trosec113 Trojan Horse Trojan Trivette TriCk Tribalzer0 Transnistria transaction Traitor traffic court Tradecraft Trade Secrets "Total System Services, Inc." Topiary Top Secret Tom Stracener TibitXimer Thumb Drive Thomson Reuters TheWikiBoat thepeoplescause the_infecti0n The Unknowns The UnderTaker The Syrian electronic army The Jokerhack Thailand ThaCosmo th3j35t3r testeux1 TEST Telecomix TehWongZ Teddy Bigglesworth TeaMp0isoN TeamHav0k Team Ghost Shell Team Digi7al tdl4 taxes TARP tango down Tampa Tammy Shapiro Taiwan Tabu T0x1c t0wN T.A.R.P. Syrian Electronic Army syndiv Symantec Corporation Switzerland Swingers Club SWIFT Sweden Swan SwaggSec Swagg Security "SunGard Data Systems, Inc." Stuxnet Stringer Streamroller Stole* Sterlok SteelAnne st0rm SQLi Spyware Spying Spydevilz Spy Camera Sposed Spook Spoofing Splendide -
Unmanned Vehicle Systems & Operations on Air, Sea, Land
Kansas State University Libraries New Prairie Press NPP eBooks Monographs 10-2-2020 Unmanned Vehicle Systems & Operations on Air, Sea, Land Randall K. Nichols Kansas State University Hans. C. Mumm Wayne D. Lonstein Julie J.C.H Ryan Candice M. Carter See next page for additional authors Follow this and additional works at: https://newprairiepress.org/ebooks Part of the Aerospace Engineering Commons, Aviation and Space Education Commons, Higher Education Commons, and the Other Engineering Commons This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License. Recommended Citation Nichols, Randall K.; Mumm, Hans. C.; Lonstein, Wayne D.; Ryan, Julie J.C.H; Carter, Candice M.; Hood, John-Paul; Shay, Jeremy S.; Mai, Randall W.; and Jackson, Mark J., "Unmanned Vehicle Systems & Operations on Air, Sea, Land" (2020). NPP eBooks. 35. https://newprairiepress.org/ebooks/35 This Book is brought to you for free and open access by the Monographs at New Prairie Press. It has been accepted for inclusion in NPP eBooks by an authorized administrator of New Prairie Press. For more information, please contact [email protected]. Authors Randall K. Nichols, Hans. C. Mumm, Wayne D. Lonstein, Julie J.C.H Ryan, Candice M. Carter, John-Paul Hood, Jeremy S. Shay, Randall W. Mai, and Mark J. Jackson This book is available at New Prairie Press: https://newprairiepress.org/ebooks/35 UNMANNED VEHICLE SYSTEMS & OPERATIONS ON AIR, SEA, LAND UNMANNED VEHICLE SYSTEMS & OPERATIONS ON AIR, SEA, LAND PROFESSOR RANDALL K. NICHOLS, JULIE RYAN, HANS MUMM, WAYNE LONSTEIN, CANDICE CARTER, JEREMY SHAY, RANDALL MAI, JOHN P HOOD, AND MARK JACKSON NEW PRAIRIE PRESS MANHATTAN, KS Copyright © 2020 Randall K. -
Selected Analytical Methods for Environmental Remediation and Recovery (SAM) 2017
EPA/600/R-17/356 | September 2017 www.epa.gov/homeland-security-research Selected Analytical Methods for Environmental Remediation and Recovery (SAM) 2017 Office of Research and Development Homeland Security Research Program This page left intentionally blank EPA/600/R-17/356 | September 2017 Selected Analytical Methods for Environmental Remediation and Recovery (SAM) 2017 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY Cincinnati, OH 45268 Office of Research and Development Homeland Security Research Program Disclaimer Disclaimer The U.S. Environmental Protection Agency (EPA) through its Office of Research and Development funded and managed the research described here under Contract EP-C-15-012 to CSRA Inc. This document is undergoing review and has not been approved for publication. The contents reflect the views of the contributors and technical work groups and do not necessarily reflect the views of the Agency. Mention of trade names or commercial products in this document or in the methods referenced in this document does not constitute endorsement or recommendation for use. Questions concerning this document or its application should be addressed to: Romy Campisano National Homeland Security Research Center Office of Research and Development (NG16) U.S. Environmental Protection Agency 26 West Martin Luther King Drive Cincinnati, OH 45268 (513) 569-7016 [email protected] Kathy Hall National Homeland Security Research Center Office of Research and Development (NG16) U.S. Environmental Protection Agency 26 West Martin Luther King -
MASINT Handbook for the Warfighter (Redacted)
__________'"*SECRET/NOFORN/VVNINTEL ' OFDIA MASINT Handbook for the Warfighter (U) Prepared by The INCA Project Office t Novemlier 1994 ;=' ··'JB :<:::251 Uf.;8 : ; ~ X5061.2 ---------S.ECRETlNOFORNfvVNINTEL MASINT Handbook for the Warfighter (U) Prepared by The INCA Project Office November 1994 UNCLASSIFIED This handbook wa.<; Ero::gar,:d hv the INCi\ Pn~ject Office under the direction of lfblf )·1 l JSC 424 I l1h)(3)'10 IISC 424 I Arc.hite.c.tur.cs., <t\s.i_;;~~d by The Analytic Science.:-; Corporation. TASCStaff Authors ..................................................... Editor.......................................................... [b)[6) Illustrations/Designs .................................. Production. S.\Jppvrt.. ..... w •. -.... , .....................,..__ ____ ___, ··-------· ·---···-·.. ·-·----- ··--··-··-··. ···------· ··------·--------.. ii UNCLASSIFIED UNCLASSIFIED . :. ... ~ :.: .. Oistribution List SUBJECT~ Measurement and Signature -Intelliga~~~- {~!NT) Handbook for the Warfigbter · l . The MASINT Handbook. for the W:~rt.i9"b:t:e.r. ia · -de.li!f;!P.).ed to demystify the world of MASINT and provi~e foc.u.s.ed· i.nf.ormation on how MAS!.NT does and can support the :war.fighter ···n<:>w· and in the future. The Handbook will be ·:an effective companion doe<Jment t.o the new MASINT Users Guide, DIAM 58-8 now in production. 2. MA.9INT ia not just scientific and techniC.iil _intelligence. ~ perceive MAS.!N'r as "In.telligence for the Fu.t.u~e ';Battlefield. 11 MASINI' is the absolutely essential th~eat., performance, signature, and profile information required to support force modernization and the effective employment of our increas~ng array of smart, brilliant, high-t-ecnnology weapons. r:~ tne future, the gathering of this informa~ion will require strong intelligence and operational partnerships to include coope.ra·tive use and integration of collection resources. -
Prevention of Biothreats: a Look Ahead
Center for Biosecurity of UPMC Prevention of Biothreats: A Look Ahead SUMMARY REPORT OF SPEAKER PRESENTATIONS AND PANEL DISCUSSIONS Prepared by the staff of the Center for Biosecurity of UPMC On October 6, 2009, the Center for Biosecurity of UPMC convened a one-day conference, Prevention of Biothreats: A Look Ahead, in Washington, DC. The conference was hosted in collaboration with the Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism, and it was funded by the Alfred P. Sloan Foundation. This meeting convened nearly 200 government officials, congressional staff members, policy analysts, scientists, health leaders, and members of the media to discuss strategies for countering biological weapons threats. During the conference, participants discussed a wide range of U.S. government programs, international approaches, and non-governmental efforts aimed at preventing the development and use of biological weapons, including: arms control and multilateral agreements; efforts to prevent the unlawful acquisition of materials, equipment, and information; deterrence, intelligence, and surveillance; and improving resiliency to biological attacks as a means of dissuasion and prevention. Given the wide range of activities and professional groups engaged in biothreat prevention efforts, it is rare for the entire community to convene as a single group. This meeting accomplished that—the first step toward generating promising new ideas and directions for biothreat prevention and promoting greater coherence in the biopreparation community. This summary report was prepared by the staff of the Center for Biosecurity of UPMC to provide a synopsis of each day’s panel discussions and individual presentations. We invite you to visit the conference website, where you will find videos of the day’s discussions along with the conference agenda, speaker bios, the attendee list, and background readings: www.upmc-biosecurity.org/preventionconf. -
Human Leukemia T-Cell Lines As Alternatives to Animal Use for Detecting Biologically Active Staphylococcal Enterotoxin Type B
toxins Article Human Leukemia T-Cell Lines as Alternatives to Animal Use for Detecting Biologically Active Staphylococcal Enterotoxin Type B Reuven Rasooly *, Paula Do , Xiaohua He and Bradley Hernlem Foodborne Toxin Detection & Prevention Research Unit, Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Albany, CA 94710, USA; [email protected] (P.D.); [email protected] (X.H.); [email protected] (B.H.) * Correspondence: [email protected]; Tel.: +1-510-559-6478 Abstract: Staphylococcal enterotoxin type B (SEB) is associated with food poisoning. Current methods for the detection of biologically active SEB rely upon its ability to cause emesis when administered to live kittens or monkeys. This technique suffers from poor reproducibility and low sensitivity and is ethically disfavored over concerns for the welfare of laboratory animals. The data presented here show the first successful implementation of an alternative method to live animal testing that utilizes SEB super-antigenic activity to induce cytokine production for specific novel cell-based assays for quantifiable detection of active SEB. Rather than using or sacrificing live animals, we found that SEB can bind to the major histocompatibility complex (MHC) class II molecules on Raji B-cells. We presented this SEB–MHC class II complex to specific Vβ5.3 regions of the human T-cell line HPB-ALL, which led to a dose-dependent secretion of IL-2 that is capable of being quantified and can further detect 10 pg/mL of SEB. This new assay is 100,000 times more sensitive than the ex vivo murine splenocyte method that achieved a detection limit of 1 µg/mL. -
Development of Real-Time PCR Screening Methods for the Detection of Bacterial Toxin DNA
Development of Real-time PCR Screening Methods for the Detection of Bacterial Toxin DNA Christina Egan, Ph.D. Director, Biodefense Laboratory Wadsworth Center N New York State Dept. of Health Y S D O [email protected] H Biodefense Wadsworth Center Laboratory New York State Department of Health Overview • Wadsworth Center Biodefense Laboratory • Utility of rtPCR as a rapid screening method • Staphylococcal enterotoxin rtPCR • Clostridium botulinum rtPCR • New and upcoming technology N Y S D O H Biodefense Wadsworth Center Laboratory New York State Department of Health Biodefense Laboratory Services Threats Training •Powders, letters, “All Hazards” •Laboratorians •Biohazard Detection System •First Responders Foods •Intentional/Unintentional Assay Development Animals •Emerging diseases •Novel technologies •Wild, domestic •Optimized methods •Outbreaks, investigations Patients Network Partnerships •Naturally occuring •LRN •Smallpox vs. Vaccination events •FERN N Y •Emerging Diseases (SARS, Flu) •ERLN, ECLRN S D •USPS, BDS O H Biodefense Wadsworth Center Laboratory New York State Department of Health rtPCR Assay Development • Follow standardized procedure in the laboratory, based on guidelines developed for clinical specimen testing • Distinct development and validation phase • Important to evaluate extraction and mastermix components of assay • Assays were designed with multiplexing capability in mind • Assays are validated as singleplex assays and evaluated to meet analytical criteria (sensitivity, N Y specificity, etc.) and then diagnostic -
1. Selected Legal Issues in CBRN-E
REVIEWER Władysław Harmata INITIATING EDITOR Beata Koźniewska TYPESETTING Munda – Maciej Torz TECHNICAL EDITOR Leonora Wojciechowska COVER DESIGN Grzegorz Zgondek, Jakub Żak Cover Image: https://commons.wikimedia.org/wiki/File:US_Navy_061031-N-9769P-413_ Students_in_the_chemical,_biological_and_radiological_phase_of_training[…] Publication distributed free of charge © Copyright by Authors, Łódź 2018 © Copyright for this edition by University of Łódź, Łódź 2018 Published by Łódź University Press First edition. W.08662.18.0.K Publisher’s sheets 42.0; printing sheets 38.875 With the financial support of Internal Security Fund Police Programme European Commission Directorate General Home Affairs This project has been founded with support from the European Commission. This publication reflects the views only of the authors, and European Commission cannot be held responsible for any use which may be made of the information contained therein ISBN 978-83-8142-184-3 e-ISBN 978-83-8142-185-0 Łódź University Press 90-131 Łódź, 8 Lindleya St. www.wydawnictwo.uni.lodz.pl e-mail: [email protected] phone. (42) 665 58 63 LIST OF AUTHORS (ALPHABETICALLY) Bielawska-Drózd Agata Nakonieczna Aleksandra Bijak Michał Nawotka Radosław Błędowski Marek Niemcewicz Marcin Brzezinka Piotr Pirszel Jacek Ceremuga Michał Podogrocki Marcin Cieślik Piotr Ponczek Michał Czerwiński Paweł Rolka Anna Dąbrowski Zbigniew Rutyna Paweł Furtak Piotr Saluk-Bijak Joanna Gaweł Jerzy Siczek Jerzy Głowacka Patrycja Skrzypczak Hubert Graniak Grzegorz Śliwiński Tomasz Grasza Mariusz -
Chondrial Ca2+ Overload. Eur J Ph
誌 上 発 表 ( 原 著 論 文 ) 185 誌 上 発 表 (原著論文) Summaries of Papers Published in Other Journals (Original Papers) Namekata, I.*, Shimada, H.*, Kawanishi, T., Tanaka, H.* were in good agreement with those previously reported in and Shigenobu, K*: Reduction by SEA0400 of myo- voltage clamped cardiomyocytes. cardial ischemia-induced cytoplasmic and mito- Keywords: Na+-Ca2+ exchange, cardiomyocyte, fl uorescence chondrial Ca2+ overload. microscopy ( ) *1 Eur J Pharmacol ., 543, 108-115 2006 東邦大学薬学部 + The cardioprotective effects of SEA0400, a novel Na - *2 大妻大学家政学部 Ca2+ exchanger inhibitor, were examined in isolated guinea pig myocardial tissue and ventricular myocytes. In a coro- Tanaka, H.*1, Shimada, H.*1, Namekata, I.*1, Kawanishi, T., nary-perfused right ventricular tissue preparation, SEA0400 Iida-Tanaka, N.*2, Shigenobu, K.*1: Involvement of the had no cardiosuppressive effect during normoxia and exper- Na+/Ca2+ exchanger in ouabain-induced inotropy imental ischemia, but enhanced the recovery of contractile and arrhythmogenesis in guinea-pig myocardium force during reperfusion. SEA0400 had no effect on tissue as revealed by SEA0400. ATP content during normoxia, but attenuated its decrease J Pharmacol Sci. , 103, 241-246( 2007) during ischemia. Treatment of ventricular myocytes with Involvement of the Na+/Ca2+ exchanger in ouabain- an ischemia mimetic solution( high K+, glucose free, pH induced inotropy and arrhythmogenesis was examined with 6.0, gassed with N2) resulted in the depolarization of the a specific inhibitor, SEA0400. In right ventricular papil- mitochondrial membrane potential and an increase in cyto- lary muscle isolated from guinea-pig ventricle, 1 microM plasmic and mitochondrial Ca2+ concentration, which had a SEA0400, which specifi cally inhibits the Na+/Ca2+ exchang- similar time course. -
Material Threat Assessment
BiologicalBiologicalLarryLarry Kerr,Kerr, ThreatThreat Ph.D.Ph.D. Agents:Agents: DeterminationDetermination andand ImplicationImplication forfor LifeLife OfficeOfficeSciencesSciences ofof ScienceScience ResearchResearch andand TechnologyTechnologyLarry Kerr, Ph.D.PolicyPolicy AssistantAssistantAssistant DirectorDirectorDirector for Homeland forfor HomelandHomeland Security Office of ScienceSecuritySecurity and Technology Policy Executive Office of the President MIT Security Studies Program MIT Faculty Club Cambridge, MA March 7, 2005 Comprehensive WMD Preparedness Strategy W MD PRE-EVENT E POST-EVENT VE NT PREVENTION PROTECTION SURVEILLANCE RESPONSE AND RECOVERY AND DETECTION RESEARCH, DEVELOPMENT AND ACQUISITION Investment Review and Prioritization THREAT ASSESSMENT AND AWARENESS Domestic & International INFORMATION MANAGEMENT AND COMMUNICATIONS FUTURE THREAT INITIATIVE Pillars of our Biodefense Program Information Management&Communications Creation andMaintenanceofInfrastructure Strengthened InternationalCooperation Research, Development andAcquisition Research, Development Biothreat Biothreat Plum IslandAnimalDiseaseCenter Plum IslandAnimalDiseaseCenter Testing andEvaluationCenter Biodefense Biodefense Testing andEvaluationCenter Bioforensic BiodefenseTHREAT Bioforensic AWARENESS Bio Characterization Bio Public Preparedness Assessment SupportCenter Assessment SupportCenter - - Countermeasures Countermeasures PREVENTION Knowledge Center Knowledge Center Analysis Center BioforensicsPROTECTION Analysis Center SURVEILLANCEAgrobio- terrorismDETECTION