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Mai Muita in Acut Ca Uti on Muunni MAIMUITA IN ACUTUS010035853B2 CA UTI ON MUUNNI (12 ) United States Patent ( 10 ) Patent No. : US 10 ,035 ,853 B2 Arathoon et al. (45 ) Date of Patent: Jul. 31, 2018 ( 54 ) SITE -SPECIFIC ANTIBODY CONJUGATION 5 , 112 , 946 A 5 / 1992 Maione METHODS AND COMPOSITIONS 5 , 122 , 368 A 6 / 1992 Greenfield et al . 5 , 191 , 066 A 3 / 1993 Bieniarz et al . 5 , 223 , 409 A 6 / 1993 Ladner et al. (71 ) Applicant : ABBVIE STEMCENTRX LLC , North 5 ,336 ,603 A 8 / 1994 Capon et al. Chicago , IL (US ) 5 , 349 ,053 A 9 / 1994 Landolfi 5 , 359 , 046 A 10 / 1994 Capon et al. (72 ) Inventors : William Robert Arathoon , Los Altos 5 , 447 , 851 A 9 / 1995 Beutler et al. 5 , 530 , 101 A 6 / 1996 Queen Hills, CA (US ) ; Ishai Padawer , San 5 , 545 , 806 A 8 / 1996 Lonberg et al. Francisco , CA (US ) ; Luis Antonio 5 , 545 , 807 A 8 / 1996 Surani et al . Cano, Oakland , CA ( US ) ; Vikram 5 , 569 , 825 A 10 / 1996 Lonberg et al . 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NM _ 016941; “ Homo sapiens delta - like 3 A61K 2039 / 505 ( 2013 .01 ) ; CO7K 2317 / 24 (Drosophila ) ( DLL3) , transcript variant 1 , mRNA ” . ( 2013. 01 ) ; CO7K 2317 /53 (2013 . 01 ) ; CO7K (Continued ) 2317 /73 (2013 .01 ) (58 ) Field of Classification Search Primary Examiner — Julie Wu None ( 74 ) Attorney , Agent, or Firm — Womble Bond Dickinson See application file for complete search history . (US ) LLP ( 56 ) References Cited (57 ) ABSTRACT Provided are novel antibody drug conjugates (ADCs ), and U . S . PATENT DOCUMENTS methods of using such ADCs to treat proliferative disorders . 4 ,676 , 980 A 6 / 1987 Segal et al. 4 , 816 , 567 A 3 / 1989 Cabilly et al. 42 Claims, 19 Drawing Sheets US 10 ,035 ,853 B2 Page 2 (56 ) References Cited 2013 /0330350 A1 12 /2013 DiMasi 2014 /0106449 Al 4 / 2014 June et al . U . S . 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