Mai Muita in Acut Ca Uti on Muunni

Mai Muita in Acut Ca Uti on Muunni

MAIMUITA IN ACUTUS010035853B2 CA UTI ON MUUNNI (12 ) United States Patent ( 10 ) Patent No. : US 10 ,035 ,853 B2 Arathoon et al. (45 ) Date of Patent: Jul. 31, 2018 ( 54 ) SITE -SPECIFIC ANTIBODY CONJUGATION 5 , 112 , 946 A 5 / 1992 Maione METHODS AND COMPOSITIONS 5 , 122 , 368 A 6 / 1992 Greenfield et al . 5 , 191 , 066 A 3 / 1993 Bieniarz et al . 5 , 223 , 409 A 6 / 1993 Ladner et al. (71 ) Applicant : ABBVIE STEMCENTRX LLC , North 5 ,336 ,603 A 8 / 1994 Capon et al. Chicago , IL (US ) 5 , 349 ,053 A 9 / 1994 Landolfi 5 , 359 , 046 A 10 / 1994 Capon et al. (72 ) Inventors : William Robert Arathoon , Los Altos 5 , 447 , 851 A 9 / 1995 Beutler et al. 5 , 530 , 101 A 6 / 1996 Queen Hills, CA (US ) ; Ishai Padawer , San 5 , 545 , 806 A 8 / 1996 Lonberg et al. Francisco , CA (US ) ; Luis Antonio 5 , 545 , 807 A 8 / 1996 Surani et al . Cano, Oakland , CA ( US ) ; Vikram 5 , 569 , 825 A 10 / 1996 Lonberg et al . Natwarsinhji Sisodiya , San Francisco , 5 .622 , 929 A 4 / 1997 Willner et al . CA (US ) ; Karthik Narayan Mani, San 5 ,625 , 126 A 4 / 1997 Lonberg et al . 5 ,633 , 425 A 5 / 1997 Lonberg et al . Francisco , CA (US ) ; David Liu , San 5 , 648 , 237 A 7 / 1997 Carter Francisco , CA (US ) 5 ,661 , 016 A 8 / 1997 Lonberg et al . 5 ,693 , 762 A 12 / 1997 Queen et al . ( 73 ) Assignee : AbbVie Stemcentrx LLC , North 5 , 750 , 373 A 5 / 1998 Garrard et al . 5 , 824 , 805 A 10 / 1998 King et al. Chicago , IL ( US ) 6 , 075 , 181 A 6 /2000 Kucherlapati et al . 6 , 150 , 584 A 11/ 2000 Kucherlapati et al . ( * ) Notice : Subject to any disclaimer, the term of this 6 , 180 , 370 B1 1 / 2001 Queen et al. patent is extended or adjusted under 35 6 ,214 , 345 Bi 4 / 2001 Firestone et al . U . S . C . 154 (b ) by 0 days . 6 , 300 , 064 B1 10 / 2001 Knappik et al. 6 , 362 , 331 B1 . 3 / 2002 Kamal et al. 6 , 376 , 217 B1 4 / 2002 Better (21 ) Appl. No .: 15 / 056 ,490 6 . 753 . 165 B16 / 2004 Cox 6 ,982 , 321 B2 1 / 2006 Winter ( 22 ) Filed : Feb . 29 , 2016 7 , 049 , 311 B1 5 / 2006 Thurston et al . 7 , 087 , 409 B2 8 / 2006 Barbas , III et al. (65 ) Prior Publication Data 7 , 189 , 710 B2 3 / 2007 Kamal et al . 7 , 279, 554 B2 10 / 2007 Chan et al . US 2016 /0176964 A1 Jun . 23, 2016 7 ,279 , 558 B2 10 / 2007 Ota et al . 7 , 407 , 951 B2 8 / 2008 Thurston et al. Related U . S . Application Data 7 , 422 , 739 B2 9 / 2008 Anderson et al . 7 , 429 , 658 B2 9 / 2008 Howard et al. (63 ) Continuation of application No . 7 , 521 , 541 B2 4 / 2009 Eigenbrot et al. PCT /US2014 / 053310 , filed on Aug . 28 , 2014 , which 7 , 557, 099 B2 7 /2009 Howard et al . is a continuation - in -part of application No . 7 , 608 , 429 B2 10 / 2009 Reilly PCT/ US2014 /053014 , filed on Aug. 27, 2014 . 7 , 619 , 068 B2 11/ 2009 Pilkington et al . 7 , 632 , 678 B2 12 / 2009 Hansford et al. (60 ) Provisional application No . 61/ 871 , 289 , filed on Aug . 7 , 659 , 241 B2 2 / 2010 Senter et al. 28 , 2013 , provisional application No. 61 /871 , 173 , 7 ,700 , 302 B2 4 / 2010 Hua et al. filed on Aug . 28 , 2013 . 7 ,723 , 485 B2 5 / 2010 Junutula 7 , 741 , 319 B2 6 / 2010 Howard et al. (51 ) Int. Cl. 7 , 825 ,267 B2 11 /2010 Koide et al. COZK 16 /28 ( 2006 .01 ) 7 , 837 , 980 B2 11/ 2010 Alley COZK 16 /30 ( 2006 .01 ) 7 , 855 ,275 B2 12/ 2010 Eigenbrot A61K 47 /48 ( 2006 . 01 ) ( Continued ) A6IK 39 / 395 ( 2006 . 01 ) CO7K 16 / 18 ( 2006 . 01 ) FOREIGN PATENT DOCUMENTS A61K 39 /00 (2006 . 01) EP 0307434 3 / 1989 (52 ) U . S . CI. EP 0367166 5 / 1990 CPC . .. .. CO7K 16 / 28 (2013 .01 ) ; A61K 47 / 48384 (Continued ) ( 2013 .01 ) ; A61K 47 / 48415 ( 2013 . 01 ) ; A61K 47 /48538 (2013 .01 ) ; A61K 47/ 48561 OTHER PUBLICATIONS ( 2013 .01 ) ; CO7K 16 / 18 (2013 .01 ) ; CO7K 16 / 2896 ( 2013 .01 ) ; C07K 16 / 30 ( 2013 .01 ) ; Accession No . NM _ 016941; “ Homo sapiens delta - like 3 A61K 2039 / 505 ( 2013 .01 ) ; CO7K 2317 / 24 (Drosophila ) ( DLL3) , transcript variant 1 , mRNA ” . ( 2013. 01 ) ; CO7K 2317 /53 (2013 . 01 ) ; CO7K (Continued ) 2317 /73 (2013 .01 ) (58 ) Field of Classification Search Primary Examiner — Julie Wu None ( 74 ) Attorney , Agent, or Firm — Womble Bond Dickinson See application file for complete search history . (US ) LLP ( 56 ) References Cited (57 ) ABSTRACT Provided are novel antibody drug conjugates (ADCs ), and U . S . PATENT DOCUMENTS methods of using such ADCs to treat proliferative disorders . 4 ,676 , 980 A 6 / 1987 Segal et al. 4 , 816 , 567 A 3 / 1989 Cabilly et al. 42 Claims, 19 Drawing Sheets US 10 ,035 ,853 B2 Page 2 (56 ) References Cited 2013 /0330350 A1 12 /2013 DiMasi 2014 /0106449 Al 4 / 2014 June et al . U . S . PATENT DOCUMENTS 2014 / 0120581 A1 5 / 2014 Niwa 2014 /0127239 A1 5 / 2014 Howard 8 , 008 , 443 B2 8 / 2011 Dall ' Acqua 2014 / 0348839 Al 11/ 2014 Chowdhury et al. 8 ,029 , 984 B2 10 / 2011 Alitalo et al . 2014 / 0363455 Al 12 / 2014 Stull et al. 8 , 034 , 808 B2 10 / 2011 Delavault et al . 2014 /0363826 Al 12 /2014 Stull et al . 8 ,053 , 562 B2 11/ 2011 Humphreys 2014 / 0363887 A112 / 2014 Stull et al . 8 , 133 , 857 B2 3 / 2012 Aikawa 2014 /0364590 Al 12 /2014 Stull et al . 8 ,163 , 736 B2 . 4 / 2012 Gauzy et al. 2014 / 0364593 Al 12 / 2014 Stull et al . 8 , 226 , 945 B2 7 / 2012 Ebens 2014 / 0370037 Al 12 / 2014 Stull et al. 8 , 507 ,654 B2 8 / 2013 Baker 2015 / 0005477 AL 1 / 2015 Lowman 8 , 557 , 965 B2 10 / 2013 Saunders et al . 2015 /0018531 A1 * 1 / 2015 Saunders CO7K 16 / 28 8 ,788 , 213 B2 7 / 2014 Bright et al . 530 / 388 . 2 8 , 865 , 875 B2 10 / 2014 Liu 2015 / 0030636 AL 1 / 2015 Dylla et al . 8 , 986 , 972 B2 3 / 2015 Stull et al. 2015 /0265724 Al 9 / 2015 Stull et al . 9 , 089, 615 B2 7 / 2015 Stull et al. 2015 / 0320879 Al 11/ 2015 Lyon 9 , 089, 616 B2 7 / 2015 Stull et al. 2015 /0328332 A1 11/ 2015 Stull et al. 9 , 089 , 617 B2 7 / 2015 Stull et al . 2015 / 0337048 Al 11/ 2015 Stull et al . 9 , 090 , 683 B2 7 / 2015 Stull et al . 2016 / 0015828 Al 1 /2016 Torgov et al. 9 ,107 , 961 B2 8 / 2015 Stull et al. 2016 / 0075779 Al 3 /2016 Stull et al . 9 , 133 ,271 B1 9 / 2015 Stull et al. 2016 / 0130331 A1 5 / 2016 Stull et al. 9 , 150 ,664 B2 10 / 2015 Kufer et al. 2016 / 0136296 Al 5 / 2016 Stull et al. B1 10 / 2015 Stull et al. 2016 /0151513 Al 6 /2016 Stull et al . 9 , 173 ,959 B1 11/ 2015 Stull et al. 2016 / 0158379 A1 6 / 2016 Stull et al . 9 ,334 , 318 B15 / 2016 Stull et al. 2016 /0175460 A1 * 6 /2016 Arathoon . .. .. A61K 47 /481 9 , 345 ,784 B15 / 2016 Stull et al . 424 / 181. 1 9 ,352 , 051 B1 . 5 / 2016 Stull et al . 2016 / 0176964 A1 6 / 2016 Arathoon et al . 9 , 353 , 182 B2 5 / 2016 Stull et al. 2016 /0228571 AL 8 /2016 Stull et al. 9 , 358 , 304 B1 6 / 2016 Stull et al . 2017 /0369571 A1 * 12 /2017 Saunders CO7K 16 /28 9 ,676 , 850 B2 * 6 / 2017 Saunders . .. .. .. .. CO7K 16 /28 2003 /0180784 AL 9 / 2003 McCarthy et al. FOREIGN PATENT DOCUMENTS 2003 / 0211991 A1 11/ 2003 Su 2004 / 0067490 AL 4 / 2004 Zhong et al. EP 2530091 A112 /2012 2004 / 0101920 A15 / 2004 Radziejewski et al. JP 58 - 180487 10 / 1983 2005 / 0008625 AL 1 / 2005 Balint et al . JP 2009 - 523709 A 6 / 2009 2005 /0152894 Al 7 / 2005 Krummen JP 2011 - 516520 A 5 / 2011 2005 / 0238649 Al 10 / 2005 Doronina et al . 2016 -030269 5 / 2016 2006 /0120959 AL 6 / 2006 De Haen et al . wo WO 91/ 00360 1 / 1991 2007/ 0141066 A1 6 / 2007 Phillips et al . wo WO 91/ 06570 5 / 1991 2007 /0154889 Al 7 / 2007 Wang WO WO 91/ 17271 11 / 1991 2007 / 0292414 A 12 / 2007 Duntsch et al . WO WO 92 / 00373 1 / 1992 2008 /0138313 Al 6 / 2008 Frankel WO WO 92 /01047 1 / 1992 2008/ 0175870 A1 7 / 2008 Mather et al. WO WO 92 / 09690 6 / 1992 2008 / 0220448 AL 9 / 2008 Blincko et al. WO WO 92 / 15679 9 / 1992 2008 /0305044 Al 12 / 2008 McDonagh et al. wo WO 92 / 18619 10 / 1992 2009 / 0010945 A11 / 2009 Alley et al . WO WO 92 / 20791 11 / 1992 2009 / 0130105 A15 / 2009 Glaser et al. WO WO 93/ 01288 1 / 1993 2009 /0155255 AL 6 / 2009 Glaser et al. WO WO 94 / 04690 3 / 1994 2009 / 0324614 A1 * 12 / 2009 TenHoor .. .. .. .. .. G01N 33/ 68 WO WO 96 /04388 2 / 1996 424 / 172 . 1 WO WO 96 /07754 3 / 1996 2010 /0162416 Al 6 / 2010 Krtolica et al . WO WO 96 / 27011 9 / 1996 2010 /0184021 Al 7 / 2010 Sella - Tavor et al. wo WO 97 / 33899 9 / 1997 2010 /0184119 A1 7 / 2010 Bright et al . wo WO 97 / 34911 9 / 1997 2010 /0184125 A 7 / 2010 Huang et al. WO WO 98 / 52976 11 / 1998 2010 /0273160 A 10 / 2010 Donahoe et al.

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