Proceedings of the Nutrition Society Intracellular Zinc in Insulin Secretion

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( 107 . ) erae ii eoiain concomitant peroxidation, lipid Decreased . ’ iae TN hshts n tensin and phosphatase PTEN, kinase; 2+ nislnsgaln r hw in shown are signalling insulin on 2+ ( 79 Conclusions hudb osdrda ohan both as considered be should ) . ( 108 ) oeta sites Potential . https://www.cambridge.org/core/terms Downloaded from Proceedings of the Nutrition Society niiulscin ee .A . Abstract, R., A. G. and were: Zn writing C., P. the Conclusions; sections Introduction, coordinated and individual designed the R. assembled A. G. None. arneFlosi 1/043)adW .the R.D. for M. UK (BB/K001442/1). W. Diabetes grant Council project Research thanks for and Sciences H. Biological (12/0004431) and J. Biotechnology Fellowship are D. companies R.). Lawrence which A. EFPIA (G. of and 2013) resources agreement Union (IMIDIA), grant of composed under 155005 Undertaking No. Medicines Innovative Joint the from Initiative support publica- received Wolfson this has to Society leading tion Senior work Royal The Trust Award. a Merit Wellcome Research and a (MR/J0003042/1) by Programme Grant MRC supported (WT098424AIA), was Award Investigator R. A. G. Stasiuk Graeme and discussion. useful London), for (Queen Hull) of of Watkinson (University Michael University College), Mary, Nicolas (Imperial (AstraZeneca), Hogstrand Long Chimienti Christer Fabrice University), University), Hopkins (King Dax (Johns University), (Eindhoven Fu Merkx Maarten thank We .K . .J . .S n .H,ZnT8. H., M. Introduction; and S. M., A. H., J. W. D. M., action; K. R. insulin and Introduction fZT nteguoehmotssaddaee ikin risk resolved diabetes be and to homeostasis remain glucose man, the in role ZnT8 the of including controversies, important Nonetheless, .Mgeo R uahna M&RyW r(97 The (1987) Jr WJ Ray & JM Puvathingal GR, Magneson 2. .Aden ,BniL,BriiIF Bertini LF, Banci C, Andreini 3. .MrtW(03 icbohmsr:fo igezn en- zinc single a from biochemistry: Zinc (2013) W Maret 4. .Paa S(03 icvr fhmnzn de zinc human of Discovery (2013) AS Prasad 1. ocnrtoso reMg free of concentrations yet e lmn flife. of element key a to zyme t mato ua elhaddisease. and health human on 176 impact its lo plasma. blood icpoen noe ntehmngenome. human the Res in encoded zinc-proteins ’ ’ olg odn,McalWelr(Toronto Wheeler Michael London), College s https://www.cambridge.org/core eet rmwr rgam (FP7/2007 Programme Framework Seventh s – 5 190. 196 , – fi 201. fi aca otiuinfo h European the from contribution nancial a aucit he otiuost the to contributors Chief manuscript. nal ilChem Biol J Con Acknowledgements iaca Support Financial . https://doi.org/10.1017/S0029665115003237 fl Authorship References cso Interest of icts ( 82 . IPaddress: 2+ 262 ) . d Nutr Adv ’ 11140 , n reZn free and tal et nkn contribution kind in 2+ 170.106.35.234 20)Cutn the Counting (2006) . mgn;E .B., A. E. imaging; – 11148. 4 ,82 2+ d Nutr Adv – 91. Proteome J , on nequine in fi 28 Sep2021 at04:26:33 ciency: icaddaee 69 diabetes and Zinc 4 – , 9 atrK,YugA amrA 21)Fluorescent (2014) AE Palmer & AM Young KP, Carter 19. 8 eSlaA,MoyT rgtG 20)Fluorescent (2009) GD Wright & TS Moody AP, Silva de 18. 7 eSlaA,FxD,MoyTS Moody DB, Fox AP, Silva de 17. ions metal Visualizing (2012) AE Palmer & Y Qin KM, Dean 16. 5 at H&AdesG 20)Udrtnigthe Understanding (2007) GK Andrews & JH Laity 15. GA Rutter HY, Chae P, Gilon 14. 3 aaaiS aaaSgw ,Hsgw A Hasegawa K, Sakata-Sogawa S, Yamasaki 13. 2 aa ,Rn as 21)Zn inl nneutro- in signals Zinc (2013) H Haase & L Rink R, Hasan 12. 1 iY&MrtW(09 Transient (2009) W Maret & Y Li 11. 2 se Y(91 o-irpietcnqefrloading for technique non-disruptive A (1981) RY Tsien 22. WJ Qian ZL, Zhou KR, Gee 21. 3 i ,MrnaJ,Sodr CI Stoddard JG, Miranda Y, Qin 23. 4 hmsnK okr ooi W(02 Predicting (2012) RW Horobin & P Dockery K, Thompson 24. 0 rzlA a ae 20)Tezinc/thiolate The (2007) W Maret & Q Hao A, Krezel 10. 0 aesiP,Fre J&BtsW 19)Creainof Correlation (1993) WH Betts & IJ Forbes PD, Zalewski 20. .Vnebr L iosnT,BlooEA Bellomo TJ, Nicolson JL, Vinkenborg 7. .JogJ&Ed J(03 h L3 aiyo ictrans- zinc of family SLC39 The (2013) DJ Eide & J Jeong 6. .Tyo M icxS ihlo RI Nicholson S, Hiscox KM, Taylor 9. .HagL&TpaonehS(03 h L3 aiyof family SLC30 The (2013) S Tepaamorndech & L Huang 5. .Caosa ,Tna ,Mu G Meur E, Tuncay P, Chabosseau 8. , subjectto theCambridgeCore termsofuse,available at esr o esrn ea osi iigsystems. living in ions metal Rev measuring for sensors E poonue lcrntase)snosa potent as sensors transfer) tools. electron analytical (photoinduced PET 19 molecular of ment probes. and approaches, techniques, analytical of overview an cells: in ehnsso icsnigb ea-epneelement (MTF-1). metal-response factor-1 Biophys by transcription zinc-sensing binding of mechanisms diabetes. 2 Type in Calcium and health Cell in beta-cells pancreatic in ing ici oe nrclua eodmessenger. second intracellular 177 novel a is Zinc hlgauoye r eurdfrtefraino neutro- of formation traps. the extracellular for phil required are granulocytes phil proliferation. 2470. cell in ions zinc lular eeial noe RTsnost oio intracellular monitor Zn to sensors FRET encoded Genetically acu ufr n niaosit cells. into indicators and buffers calcium using beta-cells 776 pancreatic from anew secretion zinc of imaging porters. 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