DOCSLIB.ORG

Histopathologic Classification of 171 Cases of Canine and Feline Non-Hodgkin Lymphoma According to The

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Histopathologic Classification of 171 Cases of Canine and Feline Non-Hodgkin Lymphoma According to The Original Article DOI: 10.1111/j.1476-5829.2009.00201.x Histopathologic classification of 171 cases of canine and feline non-Hodgkin lymphoma according to the WHO E. Vezzali1,2,A.L.Parodi3,P.S.Marcato1 and G. Bettini1 1Department of Veterinary Public Health and Animal Pathology, Pathological Anatomy Service Alma Mater Studiorum-University of Bologna, Italy 2Pathology Department, R.T.C.-Research Toxicology Center S.p.A., Via Tito Speri 12-14, I-00040 Pomezia, Rome, Italy 3Departement d’Anatomie Pathologique, Ecole Nationale Vet´ erinaire´ d’Alfort, France Abstract A retrospective collection of 171 lymphoid neoplasms (123 dogs and 48 cats) was classified according to the Revised European–American Lymphoma (REAL) classification, adopted in 2002 by the World Health Organization (WHO), to evaluate the WHO system for categorization of canine and feline neoplasms. Microscopic examination was performed after standard hematoxylin–eosin staining and immunohistochemical labelling for B (CD79a) or T (CD3) cell phenotypes. B-cell lymphomas were prevalent in dogs and T-cell lymphomas in cats. B-Large cell lymphoma (B-LCL) frequently showed plasmacytoid differentiation; notably, two canine plasma cell tumours (PCT) expressed both CD79 and CD3. There were difficulties in differentiating B-lymphoblastic lymphoma (B-LBL) from Keywords Burkitt-type lymphoma. Furthermore, intestinal T-cell lymphoma (ITCL) exhibited a huge cat, dog, immunohistochemistry, morphologic variability. Finally, multicentric mature small and thymic T-cell lymphomas were lymphoma, non-Hodgkin diagnosed, although these categories are not codified by the WHO classification. Introduction its updated version introduced a key concept based on cyto-immunological criteria, and the National Lymphomas are the most common spontaneous Cancer Institute Working Formulation (NCI-WF) haematopoietic neoplasms in dogs and cats. They simplified the lymphoma classification to high-and also represent a good animal model for human low-grade tumours. More recently, in 2002, World non-Hodgkin, lymphoma, although in man there Health Organization (WHO) published the Revised is a low proportion of high-grade lymphomas in European–American Lymphoma (REAL) classifi- comparison to pets. cation of domestic animals.3–11 This classification As in human pathology, several systems of classi- was adapted from human medicine, and it was fication have been developed during the last decades enriched by other haematopoietic myeloid tumours Correspondence address: for animal lymphoid tumours, based on morpho- under the guidance of the WHO panel of veterinary E. Vezzali logical, immunophenotypic and, recently, geno- experts. The WHO classification system for animal Pathology Department typic criteria. All classification schemes have tried R.T.C.-Research Toxicology lymphoma is a pragmatic list of haematopoietic Center S.p.A. to correlate histotypes with biological behaviour, neoplasms. It is drawn up regardless of the tumour Via Tito Speri 12-14 in order to achieve a reliable prognosis, to select origin (e.g. bone marrow or lymph nodes). Its main I-00040 Pomezia Rome, Italy efficient therapies and to give the pet owner com- goal is to correlate each category of lymphoma to e-mail: [email protected] parative information.1,2 The Kiel classification and its own behaviour and degree of malignancy.8,10,11 38 © 2009 Blackwell Publishing Ltd WHO classification of canine and feline lymphoma 39 The identification of B- or T-cell lineage is manda- same sections untreated with the chosen primary tory and generally based on the cell phenotype antibody. Tissue sections were hydrated utilizing after hematoxylin–eosin staining and confirmed xylenes and graded alcohol series. Successively, by immunophenotyping. In addition, topography quenching of endogenous peroxidase activity was of the tumour tissue must be considered.8,10,12,13 achieved by incubating the sections for 30 min in The aim of this study was to catalogue cases of 0.3% hydrogen peroxide in methanol at room tem- canine and feline lymphoma by means of the WHO perature. Antigen retrieval was achieved by applying classification, looking for correlations with the Kiel two cycles of 5 min each in a microwave oven at classification and the WF. No consideration was 750 W to the sections, dipped in EDTA buffer given to other haemolymphopoietic entities. Again, (pH = 8.00). Primary antibodies were applied we evaluated if there was a homogeneous represen- (except for negative controls), and incubated with tation of tumours within the different subtypes. buffer alone. Polyclonal rabbit anti-human CD79a clone HM57 (Dako Cytomation, CA, USA–code # M7051) diluted 1:50 in phosphate saline buffer Materials and methods (PBS) for B-cell and monoclonal mouse anti- A retrospective study was performed on more human CD3 clone F.7.2.38 (Dako–code # M7254) than 200 cases selected from 1984 to 2002, in diluted 1:75 in PBS for T-cell labelling. Incubation ◦ which a diagnosis of lymphoma was originally was completed overnight at 5 C for both anti- obtained by routine histopathological examinations bodies. Streptavidin–biotin revelation commercial performed by P. S. M. and G. B. according to kit (Dako–code # K0690) was used and the reac- the NCI-WF. Tumours other than lymphoma (i.e. tion was developed for 7 min in a dark room at myeloproliferative malignancies) were not taken room temperature with diaminobenzidine (DAB). into consideration. The histological sections of Counterstain was applied for 3 s by immersion in lymphoma were re-evaluated with a multiobserver Papanicolau hematoxylin 1:2 in water as contrast. up-right bright-field microscope, according to Some cases required toluidin blue (TB), methyl- the WHO by E. V. and A. L. P., reaching green pyronin (MGP), Gomori’s silver impregna- a consensus. For some cases, lymphoma was tion and Masson’s trichrome (MT) special staining, suspected on the basis of previous cytological respectively, to assess more closely the nuclear and examinations. Several cases were excluded from cytoplasmic detail, to emphasize the plasmacytoid the review because of missing data, poor tissue pattern, and to identify reticulin and mature colla- details and inadequate samples. Samples that lacked gen fibres. immunoreactivity, because of excessive fixation All slides were mounted with xylene-based and antigen denaturation, were excluded from the mounting media DPX (Fluka Bio Chemika Sigma- study based upon previous studies using alternative Aldrich, MO, USA). antibodies. All samples selected had been previously There were insufficient haematological and/or immunolabelled with antibodies such as Ki67, FIV–FeLV data available for cats and so this CD117, vimentin and pan-cytokeratin, so their information was excluded. fixation could be considered optimal. Finally, we Leukaemia alone was not considered in this selected 123 canine and 48 feline cases for this study. study because of the lack of information regarding For histopathology, samples were obtained haematologic examinations of our cases. mainly during necropsy and, in some cases, by The criteria used for identification of the biopsy and were fixed in 10% Carson neutral various types and subtypes are as described in buffered formalin. Three to 5 μmsectionsobtained the WHO monograph on haematopoietic tumours from blocks of paraffin wax were stained with hema- of domestic animals9 and are influenced by the toxylin–eosin (HE) and with immunohistochem- recent literature covering this subject.10 We did ical stains to demonstrate B- and T-cell lineage. not use more recent editions of the human Positive controls consisted of canine and feline nor- WHO classification because no official veterinary mal lymph nodes, while negative controls were the adaptation was available. © 2009 Blackwell Publishing Ltd, Veterinary and Comparative Oncology, 8, 1, 38–49 40 E. Vezzali et al. Results lymphocytic lymphoma (B-orT-SLL) were identified in seven dogs, three with mature B-cell and Theageoftheanimalsvariedfrom2to13 four with mature T-cell disorders. This tumour (mean 7.9) years in dogs and from 1 to 16 (mean type can be considered an accumulation, rather 9.3) years in cats. The breed distribution showed than a proliferation, of small cells with minimal the prevalence of mixed-breed carriers (29/124), cytoplasms, small round nuclei (1 to 1.5 red blood followed by the German Shepherd breed (26/124) cell in diameter), large and dense chromocenters, in dogs. Cats were mainly represented by mixed no nucleoli and with very low mitotic rate. Two out ’European’ breeds. The gender distribution in dogs of the four mature T-cell lymphomas we described was 66 entire males (M) or male castrates (C), 51 were multicentric without leukaemic involvement. entire (F) or spayed (S) females and 6 cases that B-cell lymphomas with nuclei slightly larger were unknown. In cats the gender distribution was and more vesicular than B-SLL are called B-cell 31 M or C and 17 F or S. lymphocytic lymphoma of intermediate type (LLI) In Table 1, the categories of lymphoid neoplasms (seen in one dog). The same characteristics asso- are quoted according to the WHO classification and ciated with a moderate quantity of densely stained to their equivalents in the WF. The main cellular eccentric cytoplasm are typical of lymphoplasma- pattern is given according to the Kiel classification. cytic lymphoma (LPL), which was observed in four The results relating to the tumour types, divided by dogs. species, are summarized in Tables 2 (dogs) and 3 Large granular lymphocyte lymphoma (LGL)was (cats).
Load more

Recommended publications
  • Primary Cutaneous Anaplastic Large Cell Lymphoma / Lymphomatoid
    Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders Definition A spectrum of related conditions originating from transformed or activated CD30-positive T-lymphocytes May coexist in individual patients Clonally related Overlapping clinical and/or histological features Clinical, histologic, and phenotypic characteristics required for diagnosis Types 1. Primary cutaneous anaplastic large cell lymphoma (C-ALCL) 2. Lymphomatoid papulosis 3. Borderline lesions C-ALCL: Definition T-cell lymphoma, presenting in the skin and consisting of anaplastic lymphoid cells, the majority of which are CD30- positive Distinction from: (a) systemic ALCL with cutaneous involvement, and (b) secondary high-grade lymphomas with CD30 expression In nearly all patients disease is limited to the skin at the time of diagnosis Assessed by meticulous staging Patients should not have other subtypes of lymphoma C-ALCL: Synonyms Lukes-Collins: Not listed (T-immunoblastic) Kiel: Anaplastic large cell Working Formulation: Various categories (diffuse large cell; immunoblastic) REAL: Primary cutaneous anaplastic large cell (CD30+) lymphoma Related terms: Regressing atypical histiocytosis; Ki-1 lymphoma C-ALCL: Epidemiology 25% of the T-cell lymphomas arising primarily in the skin. Predominantly in adults/elderly and rare in children. The male to female ratio is 1.5-2.0:1. C-ALCL: Sites of Involvement The disease is nearly always limited to the skin at the time of diagnosis Extracutaneous dissemination may occur Mainly regional lymph nodes Involvement of other organs is rare C-ALCL: Clinical Features Most present solitary or localized skin lesions which may be tumors, nodules or (more rarely) papules Multicentric cutaneous disease occurs in 20% Lesions may show partial or complete spontaneous regression (similar to lymphomatoid papulosis) Cutaneous relapses are frequent Extracutaneous dissemination occurs in approximately 10% of the patients.
    [Show full text]
  • Hematopoietic and Lymphoid Neoplasm Coding Manual
    Hematopoietic and Lymphoid Neoplasm Coding Manual Effective with Cases Diagnosed 1/1/2010 and Forward Published August 2021 Editors: Jennifer Ruhl, MSHCA, RHIT, CCS, CTR, NCI SEER Margaret (Peggy) Adamo, BS, AAS, RHIT, CTR, NCI SEER Lois Dickie, CTR, NCI SEER Serban Negoita, MD, PhD, CTR, NCI SEER Suggested citation: Ruhl J, Adamo M, Dickie L., Negoita, S. (August 2021). Hematopoietic and Lymphoid Neoplasm Coding Manual. National Cancer Institute, Bethesda, MD, 2021. Hematopoietic and Lymphoid Neoplasm Coding Manual 1 In Appreciation NCI SEER gratefully acknowledges the dedicated work of Drs, Charles Platz and Graca Dores since the inception of the Hematopoietic project. They continue to provide support. We deeply appreciate their willingness to serve as advisors for the rules within this manual. The quality of this Hematopoietic project is directly related to their commitment. NCI SEER would also like to acknowledge the following individuals who provided input on the manual and/or the database. Their contributions are greatly appreciated. • Carolyn Callaghan, CTR (SEER Seattle Registry) • Tiffany Janes, CTR (SEER Seattle Registry) We would also like to give a special thanks to the following individuals at Information Management Services, Inc. (IMS) who provide us with document support and web development. • Suzanne Adams, BS, CTR • Ginger Carter, BA • Sean Brennan, BS • Paul Stephenson, BS • Jacob Tomlinson, BS Hematopoietic and Lymphoid Neoplasm Coding Manual 2 Dedication The Hematopoietic and Lymphoid Neoplasm Coding Manual (Heme manual) and the companion Hematopoietic and Lymphoid Neoplasm Database (Heme DB) are dedicated to the hard-working cancer registrars across the world who meticulously identify, abstract, and code cancer data.
    [Show full text]
  • Indolent Non-Hodgkin's Lymphomas
    Follicular and Low-Grade Non-Hodgkin Lymphomas (Indolent Lymphomas) Stefan K Barta, M.D., M.S. Associate Professor of Medicine Leader, T Cell Lymphoma Program Perelman Center for Advanced Medicine Facts and Figures: Non-Hodgkin Lymphomas • Most common blood cancer • 7th most common cancer in the US3 • 71,850 new cases in the US in 20151 • 19,790 died of NHL in 20151 • About 549,625 people are living with a history of NHL (2012)1 • 85% of all NHLs are B-cell lymphomas2 • Follicular lymphoma = 2nd most common type, ~25% of all NHLs4 1 http://seer.cancer.gov/statfacts/html/nhl.html. 2 ACS. Detailed Guide (revised January 21, 2000): Non-Hodgkin’s Lymphoma. 3 http://www.cancer.gov/cancertopics/types/commoncancers 4 Blood 89: 3909, 1997 The Immune System T- CELLS B- CELLS Cellular immunity: Humoral immunity: helper + cytotoxic T-cells antibodies Lymphatic System Lymph Node Anatomy Lymph Node: Microscopic View germinal center Lymphocyte: Microscopic View Causes Possible cause(s): • chemical exposures (pesticides, fertilizers or solvents) • individuals with compromised immune systems • heredity • infections (e.g. H. pylori, Hep C, chlamydia trachomatis) • most patients have no clear risk factors • IN MOST CASES, THE EXACT CAUSE IS UNKNOWN Cellular Origins of Lymphomas & Leukemias PLEURIPOTENT STEM CELL ACUTE LEUKEMIAS LYMPHOID STEM CELL ACUTE LYMPHOBLASTIC LEUKEMIAS PRECURSOR T - CELL PRECURSOR B - CELL LYMPHOBLASTIC LYMPHOMAS / LEUKEMIAS MATURE T - CELL MATURE B - CELL NON-HODGKIN LYMPHOMAS / CHRONIC LYMPHOCYTIC LEUKEMIA LYMPH NODES, EXTRANODAL
    [Show full text]
  • Localized AL Amyloidosis in a Patient with Diffuse Large B-Cell Lymphoma of the Breast
    Included in the theme issue: 284 Letters to the Editor ACNE, RETINOIDS AND LYMPHOMAS Acta Derm Venereol 2012; 92: 284–285 Localized AL Amyloidosis in a Patient with Diffuse Large B-cell Lymphoma of the Breast Hsien-Yi Chiu, Chia-Yu Chu and Tsen-Fang Tsai* Department of Dermatology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan. *E-mail: [email protected] Accepted July 11, 2011. Amyloidosis refers to a variety of conditions in which a protein polysaccharide complex, amyloid protein, is accumulated locally or systemically in tissues or organs. Amyloid in the skin may be derived directly from kerati- nocytes, or secondarily from immunoglobulin light chain fragments (AL type), fragments of the acute-phase reac- tant serum amyloid A (AA type), etc. Nodular amyloido- sis (NA) is a rare type of localized AL amyloidosis, with most reported cases being of the lambda light chains (1) and is often histopathologically indistinguishable from systemic amyloidosis. Its association with lymphoma has been observed infrequently. CASE REPORT An 88-year-old woman initially noticed a 5×3 cm mass in her right breast in 1990. She was diagnosed with non-Hodgkin’s lymphoma (NHL) (diffuse large immunoblastic B-cell type, sta- ge IE) after the excision of the mass in a tertiary referral centre. Bone marrow biopsy revealed no evidence of lymphoma invol- vement. She achieved complete remission after chemotherapy. Six years after the diagnosis of lymphoma she developed multiple enlarging nodules on her legs. On examination, there were coalescing, waxy, skin-coloured, nodules with some foci of haemorrhage, central ulceration and crusts on the legs (Fig.
    [Show full text]
  • REVIEW Anti-CD20-Based Therapy of B Cell Lymphoma: State of The
    Leukemia (2002) 16, 2004–2015 2002 Nature Publishing Group All rights reserved 0887-6924/02 $25.00 www.nature.com/leu REVIEW Anti-CD20-based therapy of B cell lymphoma: state of the art C Kosmas1, K Stamatopoulos2, N Stavroyianni2, N Tsavaris3 and T Papadaki4 1Department of Medicine, 2nd Division of Medical Oncology, ‘Metaxa’ Cancer Hospital, Piraeus, Greece; 2Department of Hematology, G Papanicolaou General Hospital, Thessaloniki, Greece; 3Oncology Unit, Department of Pathophysiology, Athens University School of Medicine, Laikon General Hospital, Athens, Greece; and 4Hemopathology Department, Evangelismos Hospital, Athens, Greece Over the last 5 years, studies applying the chimeric anti-CD20 ficulties in identifying a completely tumor-specific target; (2) MAb have renewed enthusiasm and triggered world-wide appli- the impracticality of constructing a unique antibody for each cation of anti-CD20 MAb-based therapies in B cell non-Hodg- kin’s lymphoma (NHL). Native chimeric anti-CD20 and isotope- patient; (3) the development of an immune response to murine 6 labeled murine anti-CD20 MAbs are currently employed with immunoglobulins (human anti-mouse antibodies, HAMA). By encouraging results as monotherapy or in combination with the end of the 1980s enthusiasm for therapeutic MAbs was conventional chemotherapy and in consolidation of remission waning; murine native (unconjugated), radioactively labeled after treatments with curative intent (ie after/ in combination or toxin-conjugated MAbs failed to yield significant clinical with high-dose chemotherapy and hematopoietic stem cell responses; moreover, they were not uncommonly associated rescue). On the available experience, anti-CD20 MAb-based therapeutic strategies will be increasingly integrated in the with toxicities, predominantly in the form of serum sickness treatment of B cell NHL and related malignancies.
    [Show full text]
  • Molecular and Immunological Dissection of Diffuse Large
    Leukemia (1999) 13, 1441–1447 1999 Stockton Press All rights reserved 0887-6924/99 $15.00 http://www.stockton-press.co.uk/leu ,Molecular and immunological dissection of diffuse large B cell lymphoma: CD5؉ and CD5؊ with CD10؉ groups may constitute clinically relevant subtypes S Harada1,2, R Suzuki1, K Uehira3, Y Yatabe4, Y Kagami3, M Ogura3, H Suzuki5, A Oyama6, Y Kodera7, R Ueda2, Y Morishima3, S Nakamura4 and M Seto1 1Laboratory of Chemotherapy, Aichi Cancer Center Research Institute; 3Department of Hematology and Chemotherapy, 4Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital; 2Second Department of Internal Medicine, Nagoya City University School of Medicine; 5Department of Internal Medicine, Okazaki Municipal Hospital; 6Department of Internal Medicine, Aichi Prefectural Hospital; 7Department of Internal Medicine, Japanese Red Cross, Nagoya First Hospital, Japan Diffuse large B cell lymphoma (DLBL) constitutes the greatest genotypic parameters were found not to be helpful for deline- percentage of adult non-Hodgkin’s lymphomas and represents ating distinctive morphologic subgroups). DLBL accounts for a diverse spectrum of lymphoid neoplasms. Clinicopathologic, the greatest percentage (48%) of adult non-Hodgkin’s lym- phenotypic and genotypic findings were correlated and com- 4 pared for 63 DLBL cases to investigate whether they represent phoma (NHL) among Japanese patients and for about 40% clinically relevant subtypes. They were all cyclin D1 negative of initial NHL diagnoses in the United States.5 Among DLBL, and were phenotypically divided into three groups, ie group I only a few entities, eg primary mediastinal large B cell lym- + − + (CD5 type, n = 11), group II (CD5 CD10 type, n = 19), and phoma characterized by the fact that it has a peculiar disease − − = group III (CD5 CD10 type, n 33).
    [Show full text]
  • V1 Madrid 3 Intro.Pdf
    Clasificación de la OMS de las neoplasias linfoides is about to begin! Please silence your cellphones, beepers, person sitting next to you….. When Dr. Campo asked me to provide this introduction, I had to think long and hard before agreeing to prepare it for this course & deciding how to do it but….. he is a good friend so …… Clasificación de los linfomas. Evolución conceptual. Please do not be disappointed The remainder of this presentation is in American Style English However, this is an international story not from just one family tree nor one side of the Atlantic So let’s begin! S. Fairey Lymphoma classification over the last half- century: A tale of evolution & revolution The Rappaport classification 1966 1974 Lymphomas are neoplasms of the immune system and should be categorized as such! The “functional” lymphoma classifications Cells of the normal immune system Lukes & Collins, Cancer 34:1488, 1974 Morphology & immunophenotype R. D. Collins - Vanderbilt R. L. Lukes - USC 1974 K. Lennert Signing off on the Kiel classification The 1970’s were very exciting but tumultuous times – not everyone was on the same page! “It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness….” The 1970’s were very exciting but tumultuous times – not everyone was on the same page! “It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness….” Lancet 1974 7;2(7880): 586 Lancet 1974 7;2(7880): 586 NCI Working Formulation Cancer 49:2112, 1982 Morphologic classification based in large part on survival data from the late 1970s.
    [Show full text]
  • An Overview of the Classification of Non-Hodgkin's Lymphomas: an Integration of Morphological and Phenotypical Concepts1
    [CANCER RESEARCH (SUPPL.) 52, 5447s-5452s. October I. 1992| An Overview of the Classification of Non-Hodgkin's Lymphomas: An Integration of Morphological and Phenotypical Concepts1 Elaine S. Jaffe,2 Mark Raffeid, L. Jeffrey Medeiros, and Maryalice Stetler-Stevenson Hematopathology Section, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 20982 Abstract As a result of this dissatisfaction, a variety of classification An analysis of trends in the incidence of non-Hodgkin's lymphoma schemes were proposed. Two of them, the Lukes and Collins Classification (3) and the Kiel Scheme (4), as proposed by Len- requires an understanding of individual disease entities within this broad group. The non-Hodgkin's lymphomas represent a diverse group nert and colleagues, are shown in Table 1. The complexity of of malignancies that have in common an origin from lymphoid cells. this terminology is obvious. All of these terms have been in Nevertheless, these disorders are heterogeneous in their clinical behav International Classification of Diseases for Oncology, and ior, morphological appearance, cellular origin, etiology, and pathogen- probably all are reflected in the SEER data at one point or esis. A modern classification of non-Hodgkin's lymphomas must include another. Moreover, if one tries to discern individual disease an integration of morphological, immunophenotypical, and molecular entities from these data, it is virtually impossible. concepts in order to delineate individual diseases within this broad The National Cancer Institute responded to this problem by group. Existing classification schemes such as the working formulation, funding a study to test the six major classification schemes while they may be useful in providing a guide to clinical management, cannot provide this information in the absence of other data.
    [Show full text]
  • The Spectrum of B Cell Neoplasia
    Henry Ford Hospital Medical Journal Volume 32 Number 1 Article 6 3-1984 The Spectrum of B Cell Neoplasia Michael J. Deegan Follow this and additional works at: https://scholarlycommons.henryford.com/hfhmedjournal Part of the Life Sciences Commons, Medical Specialties Commons, and the Public Health Commons Recommended Citation Deegan, Michael J. (1984) "The Spectrum of B Cell Neoplasia," Henry Ford Hospital Medical Journal : Vol. 32 : No. 1 , 20-30. Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol32/iss1/6 This Article is brought to you for free and open access by Henry Ford Health System Scholarly Commons. It has been accepted for inclusion in Henry Ford Hospital Medical Journal by an authorized editor of Henry Ford Health System Scholarly Commons. Henry Ford Hosp Med Vol 32, No 1, 1984 The Spectrum of B Cell Neoplasia Michael J. Deegan, MD^ Recenf progress in our understanding of the immune peutic implications of these discoveries are now being system and the development of new techniques that explored. This paper presents a concise overview of the permit the precise identification of lymphocytes have differentiation of human B lymphocytes, the surface and permitted a reexamination of lymphoid neoplasms. cytoplasmic markers that permit their recognition, and Most ofthe non-Hodgkin's lymphomas and lymphocytic the diverse tumors that are now known to be malignant leukemias have been characterized as T or B cell neo­ counterparts of normal B cell elements. Particular em­ plasms and have been shown to possess features similar phasis is placed on the utility of surface and cytoplasmic to those expressed by normal lymphoid cells at different immunoglobulin as unique B cell markers and on the stages of maturation.
    [Show full text]
  • Uva-DARE (Digital Academic Repository)
    UvA-DARE (Digital Academic Repository) CD20 monoclonal antibody therapy for B-cell lymphona van der Kolk, L.E. Publication date 2001 Link to publication Citation for published version (APA): van der Kolk, L. E. (2001). CD20 monoclonal antibody therapy for B-cell lymphona. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:29 Sep 2021 CC h a p t e Introductionn and outline of the thesis Introductionn and outline of the thesis Introduction n Low-gradee non-Hodgkin's lymphoma (NHL) Non-Hodgkin'ss lymphomas are a heterogeneous group of malignancies of mature lymphoid cells.. Over 90% of the non-Hodgkin's lymphomas is of B-cell origin. The clinical course variess from indolent to highly aggressive.
    [Show full text]
  • Staging and Classification of Lymphoma
    Staging and Classification of Lymphoma Ping Lu, MD In 2004, new cases of non-Hodgkin’s lymphoma in the United States were estimated at 54,370, representing 4% of all cancers and resulting 4% of all cancer deaths, and new cases of Hodgkin’s lymphoma were estimated at 7,880. The appropriate staging and management of lymphomas greatly depend on an accurate pathological diagnosis and classification. The recently established Revised European–American Classification of Lymphoid Neoplasms (REAL) and the subsequently adopted and updated World Health Organization (WHO) classification include modern cytogenetic, molecular, and immu- nologic techniques and knowledge and reach an international consensus on the clas- sification of lymphomas. This classification scheme represents an advance in our understanding of lymphomas and serves as an operative guideline for studying and diagnosing lymphomas. Imaging techniques always have served as staging and moni- toring tools for the clinical management of lymphomas. The understanding and adoption of the current classification system is important in refining the role of imaging modal- ities in the management of specific lymphoma. To help one understand the current classification, this current review gives a brief history of lymphoma classifications and summaries the recent classification schemes, including new entities, clinical staging methods, and clinical prognostic criteria. Semin Nucl Med 35:160-164 © 2005 Elsevier Inc. All rights reserved. uring past decades, because of the lack of knowledge according to their natural history, their response to ther- Din the lymphoma biology, the diagnosis and classifi- apy, and their survival in the patients recruited in the cation of lymphoma were based solely on morphology.
    [Show full text]
  • Diffuse Large B-Cell Non-Hodgkin Lymphomas
    British Journal of Cancer (1999) 79(11/12), 1770–1776 © 1999 Cancer Research Campaign Article no. bjoc.1998.0282 Diffuse large B-cell non-Hodgkin lymphomas: the clinical relevance of histological subclassification JW Baars1, D de Jong2, EM Willemse3, L Gras4, O Dalesio4, P v. Heerde2, PC Huygens5, H v.d. Lelie6 and AEG Kr v.d. Borne1,6 1Division of Medical Oncology, Department of Hematology, 2Department of Pathology, 3Department of Scientific and Patient Administration, 4Department of Biometrics, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121,1066 CX Amsterdam, The Netherlands; 5Department of Hematology, Academic Hospital of the Free University, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands; 6Division of Internal Medicine, Department of Hematology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Summary In the REAL classification the diffuse large B-cell non-Hodgkin lymphomas (NHL) are grouped together, because subclassifications are considered to lack both reproducibility and clinical significance. Others, however, claim that patients with an immunoblastic NHL have a worse prognosis than patients with other types of diffuse large B-cell NHL. Therefore, we investigated the prognostic and clinical significance of histological subclassification of diffuse large B-cell NHL in a uniformly treated series of patients. For this retrospective study, all patients diagnosed as having an immunoblastic (IB) B-cell NHL by the Lymphoma Review Panel of the Comprehensive Cancer Center Amsterdam (CCCA) between 1984 and 1994, and treated according to the guidelines of the CCCA, were analysed. Patients with a centroblastic polymorphic subtype (CB-Poly) or centroblastic (CB) NHL by the Lymphoma Review Panel who were treated in the Netherlands Cancer Institute during the same period according to CCCA guidelines were used as reference groups.
    [Show full text]