Bone Marrow and Peripheral Blood Changes in Non-Hodgkin's
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Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation
Hindawi Publishing Corporation Case Reports in Oncological Medicine Volume 2016, Article ID 7953745, 4 pages http://dx.doi.org/10.1155/2016/7953745 Case Report Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation A. Vennepureddy,1 V. Motilal Nehru,1 Y. Liu,2 F. Mohammad,3 andJ.P.Atallah3 1 Department of Internal Medicine, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA 2Department of Pathology, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA 3Division of Hematology and Oncology, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA Correspondence should be addressed to A. Vennepureddy; [email protected] Received 20 December 2015; Accepted 24 April 2016 Academic Editor: Su Ming Tan Copyright © 2016 A. Vennepureddy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The cooccurrence of more than one oncologic illness in a patient can present a diagnostic challenge. Here we report an unusual case of concomitant existence of multiple myeloma, breast cancer, and monoclonal B-cell lymphocytosis on initial presentation. The challenge was to accurately diagnose each disease and stage in order to maximize the therapeutic regimen to achieve cure/remission. Successful management of the patient and increased life expectancy can be achieved by multidisciplinary management and patient- oriented approach in multiple primary malignant synchronous tumors. 1. Introduction different patterns of MPMs should be considered. Thera- peutically, a multidisciplinary and patient-oriented approach Multiple primary malignant tumors (MPMTs) are rarely should be considered. -
Primary Cutaneous Anaplastic Large Cell Lymphoma / Lymphomatoid
Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders Definition A spectrum of related conditions originating from transformed or activated CD30-positive T-lymphocytes May coexist in individual patients Clonally related Overlapping clinical and/or histological features Clinical, histologic, and phenotypic characteristics required for diagnosis Types 1. Primary cutaneous anaplastic large cell lymphoma (C-ALCL) 2. Lymphomatoid papulosis 3. Borderline lesions C-ALCL: Definition T-cell lymphoma, presenting in the skin and consisting of anaplastic lymphoid cells, the majority of which are CD30- positive Distinction from: (a) systemic ALCL with cutaneous involvement, and (b) secondary high-grade lymphomas with CD30 expression In nearly all patients disease is limited to the skin at the time of diagnosis Assessed by meticulous staging Patients should not have other subtypes of lymphoma C-ALCL: Synonyms Lukes-Collins: Not listed (T-immunoblastic) Kiel: Anaplastic large cell Working Formulation: Various categories (diffuse large cell; immunoblastic) REAL: Primary cutaneous anaplastic large cell (CD30+) lymphoma Related terms: Regressing atypical histiocytosis; Ki-1 lymphoma C-ALCL: Epidemiology 25% of the T-cell lymphomas arising primarily in the skin. Predominantly in adults/elderly and rare in children. The male to female ratio is 1.5-2.0:1. C-ALCL: Sites of Involvement The disease is nearly always limited to the skin at the time of diagnosis Extracutaneous dissemination may occur Mainly regional lymph nodes Involvement of other organs is rare C-ALCL: Clinical Features Most present solitary or localized skin lesions which may be tumors, nodules or (more rarely) papules Multicentric cutaneous disease occurs in 20% Lesions may show partial or complete spontaneous regression (similar to lymphomatoid papulosis) Cutaneous relapses are frequent Extracutaneous dissemination occurs in approximately 10% of the patients. -
Monoclonal B-Cell Lymphocytosis Is Characterized by Mutations in CLL Putative Driver Genes and Clonal Heterogeneity Many Years Before Disease Progression
Leukemia (2014) 28, 2395–2424 © 2014 Macmillan Publishers Limited All rights reserved 0887-6924/14 www.nature.com/leu LETTERS TO THE EDITOR Monoclonal B-cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progression Leukemia (2014) 28, 2395–2398; doi:10.1038/leu.2014.226 (Beckton Dickinson) and data analyzed using Cell Quest software. On the basis of FACS (fluorescence-activated cell sorting) analysis, we observed after enrichment an average of 91% of CD19+ cells Monoclonal B-cell lymphocytosis (MBL) is defined as an asympto- (range 76–99%) and 91% of the CD19+ fraction were CD19+/CD5+ matic expansion of clonal B cells with less than 5 × 109/L cells in the cells (range 66–99%). We used the values of the CD19+/CD5+ peripheral blood and without other manifestations of chronic fraction to calculate the leukemic B-cell fraction and reduce any lymphocytic leukemia (CLL; for example, lymphadenopathy, cyto- significant contamination of non-clonal B cells in each biopsy. DNA penias, constitutional symptoms).1 Approximately 1% of the MBL was extracted from the clonal B cells and non-clonal (that is, T cells) cohort develops CLL per year. Evidence suggests that nearly all CLL cells using the Gentra Puregene Cell Kit (Qiagen, Hilden, Germany). 2 fi fi cases are preceded by an MBL state. Our understanding of the Extracted DNAs were ngerprinted to con rm the relationship genetic basis, clonal architecture and evolution in CLL pathogenesis between samples of the same MBL individual and to rule out sample has undergone significant improvements in the last few years.3–8 In cross-contamination between individuals. -
Follicular Lymphoma with Leukemic Phase at Diagnosis: a Series Of
Leukemia Research 37 (2013) 1116–1119 Contents lists available at SciVerse ScienceDirect Leukemia Research journa l homepage: www.elsevier.com/locate/leukres Follicular lymphoma with leukemic phase at diagnosis: A series of seven cases and review of the literature a c c c c Brady E. Beltran , Pilar Quinones˜ , Domingo Morales , Jose C. Alva , Roberto N. Miranda , d e e b,∗ Gary Lu , Bijal D. Shah , Eduardo M. Sotomayor , Jorge J. Castillo a Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru b Division of Hematology and Oncology, Rhode Island Hospital, Brown University Alpert Medical School, Providence, RI, USA c Department of Pathology, Edgardo Rebaglati Martins Hospital, Lima, Peru d Department of Hematopathology, MD Anderson Cancer Center, Houston, TX, USA e Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA a r t i c l e i n f o a b s t r a c t Article history: Follicular lymphoma (FL) is a prevalent type of non-Hodgkin lymphoma in the United States and Europe. Received 23 April 2013 Although, FL typically presents with nodal involvement, extranodal sites are less common, and leukemic Received in revised form 25 May 2013 phase at diagnosis is rare. There is mounting evidence that leukemic presentation portends a worse Accepted 26 May 2013 prognosis in patients with FL. We describe 7 patients with a pathological diagnosis of FL who presented Available online 20 June 2013 with a leukemic phase. We compared our cases with 24 additional cases reported in the literature. Based on our results, patients who present with leukemic FL tend to have higher risk disease. -
Occult B-Lymphoproliferative Disorders Andy Rawstron
Occult B-lymphoproliferative Disorders Andy Rawstron To cite this version: Andy Rawstron. Occult B-lymphoproliferative Disorders. Histopathology, Wiley, 2011, 58 (1), pp.81. 10.1111/j.1365-2559.2010.03702.x. hal-00610748 HAL Id: hal-00610748 https://hal.archives-ouvertes.fr/hal-00610748 Submitted on 24 Jul 2011 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Histopathology Occult B-lymphoproliferative Disorders ForJournal: Histopathology Peer Review Manuscript ID: HISTOP-09-10-0521 Wiley - Manuscript type: Review Date Submitted by the 21-Sep-2010 Author: Complete List of Authors: Rawstron, Andy; St. James's Institute of Oncology, HMDS Chronic Lymphocytic Leukaemia, Non-Hodgkin Lymphoma, Keywords: Monoclonal B-cell Lymphocytosis Published on behalf of the British Division of the International Academy of Pathology Page 1 of 22 Histopathology Occult B-lymphoproliferative Disorders Andy C. Rawstron 1,2 Andy C. Rawstron, PhD Consultant Clinical Scientist HMDS, St. James's Institute of Oncology, Bexley Wing, Beckett Street, Leeds LS9 7TF, UK and HYMS, University of York, YO10 5DD, UK. Contact details: tel +44 113 206 8104, fax +44 113 206 7883, email: [email protected] Peer Review Published on behalf of the British Division of the International Academy of Pathology Histopathology Page 2 of 22 Abstract The term Monoclonal B-lymphocytosis (MBL) was recently introduced to identify individuals with a population of monoclonal B-cells in the absence of other features that are diagnostic of a B-lymphoproliferative disorder. -
MINI-REVIEW Large Cell Lymphoma Complicating Persistent Polyclonal B
Leukemia (1998) 12, 1026–1030 1998 Stockton Press All rights reserved 0887-6924/98 $12.00 http://www.stockton-press.co.uk/leu MINI-REVIEW Large cell lymphoma complicating persistent polyclonal B cell lymphocytosis J Roy1, C Ryckman1, V Bernier2, R Whittom3 and R Delage1 1Division of Hematology, 2Department of Pathology, Saint Sacrement Hospital, 3Division of Hematology, CHUQ, Saint Franc¸ois d’Assise Hospital, Laval University, Quebec City, Canada Persistent polyclonal B cell lymphocytosis (PPBL) is a rare immunoglobulin (Ig) M with a polyclonal pattern on protein lymphoproliferative disorder of unclear natural history and its electropheresis. Flow cytometry cell analysis displays the pres- potential for B cell malignancy remains unknown. We describe the case of a 39-year-old female who presented with stage IV- ence of the CD19 antigen and surface IgM with a normal B large cell lymphoma 19 years after an initial diagnosis of kappa/lambda ratio. In contrast to CLL, CD5 is absent. There PPBL; her disease was rapidly fatal despite intensive chemo- is an association between HLA-DR 7 and PPBL in more than therapy and blood stem cell transplantation. Because we had two-thirds of the patients but the reason for such an associ- recently identified multiple bcl-2/lg gene rearrangements in ation remains unclear.3,6 There has been one report of PPBL blood mononuclear cells of patients with PPBL, we sought evi- occurring in identical female twins.7 No other obvious genetic dence of this oncogene in this particular patient: bcl-2/lg gene rearrangements were found in blood mononuclear cells but not predisposition or familial inheritance has yet been described in lymphoma cells. -
Hematopoietic and Lymphoid Neoplasm Coding Manual
Hematopoietic and Lymphoid Neoplasm Coding Manual Effective with Cases Diagnosed 1/1/2010 and Forward Published August 2021 Editors: Jennifer Ruhl, MSHCA, RHIT, CCS, CTR, NCI SEER Margaret (Peggy) Adamo, BS, AAS, RHIT, CTR, NCI SEER Lois Dickie, CTR, NCI SEER Serban Negoita, MD, PhD, CTR, NCI SEER Suggested citation: Ruhl J, Adamo M, Dickie L., Negoita, S. (August 2021). Hematopoietic and Lymphoid Neoplasm Coding Manual. National Cancer Institute, Bethesda, MD, 2021. Hematopoietic and Lymphoid Neoplasm Coding Manual 1 In Appreciation NCI SEER gratefully acknowledges the dedicated work of Drs, Charles Platz and Graca Dores since the inception of the Hematopoietic project. They continue to provide support. We deeply appreciate their willingness to serve as advisors for the rules within this manual. The quality of this Hematopoietic project is directly related to their commitment. NCI SEER would also like to acknowledge the following individuals who provided input on the manual and/or the database. Their contributions are greatly appreciated. • Carolyn Callaghan, CTR (SEER Seattle Registry) • Tiffany Janes, CTR (SEER Seattle Registry) We would also like to give a special thanks to the following individuals at Information Management Services, Inc. (IMS) who provide us with document support and web development. • Suzanne Adams, BS, CTR • Ginger Carter, BA • Sean Brennan, BS • Paul Stephenson, BS • Jacob Tomlinson, BS Hematopoietic and Lymphoid Neoplasm Coding Manual 2 Dedication The Hematopoietic and Lymphoid Neoplasm Coding Manual (Heme manual) and the companion Hematopoietic and Lymphoid Neoplasm Database (Heme DB) are dedicated to the hard-working cancer registrars across the world who meticulously identify, abstract, and code cancer data. -
Lymphoproliferative Disorders
Lymphoproliferative disorders Dr. Mansour Aljabry Definition Lymphoproliferative disorders Several clinical conditions in which lymphocytes are produced in excessive quantities ( Lymphocytosis) Lymphoma Malignant lymphoid mass involving the lymphoid tissues (± other tissues e.g : skin ,GIT ,CNS …) Lymphoid leukemia Malignant proliferation of lymphoid cells in Bone marrow and peripheral blood (± other tissues e.g : lymph nods ,spleen , skin ,GIT ,CNS …) Lymphoproliferative disorders Autoimmune Infection Malignant Lymphocytosis 1- Viral infection : •Infectious mononucleosis ,cytomegalovirus ,rubella, hepatitis, adenoviruses, varicella…. 2- Some bacterial infection: (Pertussis ,brucellosis …) 3-Immune : SLE , Allergic drug reactions 4- Other conditions:, splenectomy, dermatitis ,hyperthyroidism metastatic carcinoma….) 5- Chronic lymphocytic leukemia (CLL) 6-Other lymphomas: Mantle cell lymphoma ,Hodgkin lymphoma… Infectious mononucleosis An acute, infectious disease, caused by Epstein-Barr virus and characterized by • fever • swollen lymph nodes (painful) • Sore throat, • atypical lymphocyte • Affect young people ( usually) Malignant Lymphoproliferative Disorders ALL CLL Lymphomas MM naïve B-lymphocytes Plasma Lymphoid cells progenitor T-lymphocytes AML Myeloproliferative disorders Hematopoietic Myeloid Neutrophils stem cell progenitor Eosinophils Basophils Monocytes Platelets Red cells Malignant Lymphoproliferative disorders Immature Mature ALL Lymphoma Lymphoid leukemia CLL Hairy cell leukemia Non Hodgkin lymphoma Hodgkin lymphoma T- prolymphocytic -
Indolent Non-Hodgkin's Lymphomas
Follicular and Low-Grade Non-Hodgkin Lymphomas (Indolent Lymphomas) Stefan K Barta, M.D., M.S. Associate Professor of Medicine Leader, T Cell Lymphoma Program Perelman Center for Advanced Medicine Facts and Figures: Non-Hodgkin Lymphomas • Most common blood cancer • 7th most common cancer in the US3 • 71,850 new cases in the US in 20151 • 19,790 died of NHL in 20151 • About 549,625 people are living with a history of NHL (2012)1 • 85% of all NHLs are B-cell lymphomas2 • Follicular lymphoma = 2nd most common type, ~25% of all NHLs4 1 http://seer.cancer.gov/statfacts/html/nhl.html. 2 ACS. Detailed Guide (revised January 21, 2000): Non-Hodgkin’s Lymphoma. 3 http://www.cancer.gov/cancertopics/types/commoncancers 4 Blood 89: 3909, 1997 The Immune System T- CELLS B- CELLS Cellular immunity: Humoral immunity: helper + cytotoxic T-cells antibodies Lymphatic System Lymph Node Anatomy Lymph Node: Microscopic View germinal center Lymphocyte: Microscopic View Causes Possible cause(s): • chemical exposures (pesticides, fertilizers or solvents) • individuals with compromised immune systems • heredity • infections (e.g. H. pylori, Hep C, chlamydia trachomatis) • most patients have no clear risk factors • IN MOST CASES, THE EXACT CAUSE IS UNKNOWN Cellular Origins of Lymphomas & Leukemias PLEURIPOTENT STEM CELL ACUTE LEUKEMIAS LYMPHOID STEM CELL ACUTE LYMPHOBLASTIC LEUKEMIAS PRECURSOR T - CELL PRECURSOR B - CELL LYMPHOBLASTIC LYMPHOMAS / LEUKEMIAS MATURE T - CELL MATURE B - CELL NON-HODGKIN LYMPHOMAS / CHRONIC LYMPHOCYTIC LEUKEMIA LYMPH NODES, EXTRANODAL -
Peripheral Blood Cells Changes After Two Groups of Splenectomy And
ns erte ion p : O y p H e f Yunfu et al., J Hypertens (Los Angel) 2018, 7:1 n o l A a DOI: 10.4172/2167-1095.1000249 c c n r e u s o s J Journal of Hypertension: Open Access ISSN: 2167-1095 Research Article Open Access Peripheral Blood Cells Changes After Two Groups of Splenectomy and Prevention and Treatment of Postoperative Complication Yunfu Lv1*, Xiaoguang Gong1, XiaoYu Han1, Jie Deng1 and Yejuan Li2 1Department of General Surgery, Hainan Provincial People's Hospital, Haikou, China 2Department of Reproductive, Maternal and Child Care of Hainan Province, Haikou, China *Corresponding author: Yunfu Lv, Department of General Surgery, Hainan Provincial People's Hospital, Haikou 570311, China, Tel: 86-898-66528115; E-mail: [email protected] Received Date: January 31, 2018; Accepted Date: March 12, 2018; Published Date: March 15, 2018 Copyright: © 2018 Lv Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Objective: This study aimed to investigate the changes in peripheral blood cells after two groups of splenectomy in patients with traumatic rupture of the spleen and portal hypertension group, as well as causes and prevention and treatment of splenectomy related portal vein thrombosis. Methods: Clinical data from 109 patients with traumatic rupture of the spleen who underwent splenectomy in our hospital from January 2001 to August 2015 were retrospectively analyzed, and compared with those from 240 patients with splenomegaly due to cirrhotic portal hypertension who underwent splenectomy over the same period. -
Hairy Cell Leukemia: the Good News of a Bad Disease
CASO CLÍNICO Hairy Cell Leukemia: the good news of a bad disease Mónica Seidi, Guadalupe Benites, Almerindo Rego Hospital de Santo Espírito da Ilha Terceira Abstract Hairy Cell Leukemia (HCL) is an uncommon chronic B cell Lymphoproliferative disorder characterized by the accumulation of a small mature B cell lym- phoid cells with abundant cytoplasm and “hairy” projections within the peripheral blood smear, bone marrow and splenic red pulp. Most patients with HCL present with symptons related to splenomegaly or cytopenias, including some constitucional symptons, however one quarter of them is asymptomatic and is referred due to incidental findings. The authors decided to report a clinical case of hairy cells leukemia in an asymptomatic patient due to the rarity of this neoplasia (2% of all leukemias Galicia Clínica | Sociedade Galega de Medicina Interna and less than 1% of limphoids neoplasms) and because it corresponds to the most successfully treatable leukemia. Palabras clave: Citopenias. Esplenomegalia. Enfermedad linfoproliferativa. Leucemia de células peludas. Keywords: Cytopenias. Splenomegaly. Lymphoproliferative disease. Hairy cells leukemia Introduction clonal gamma peak. The CT abdominal scan revealed homogenea Hairy cell leukemia (HCL) is an uncommon B-cell lymphopro- splenomegaly with no limphadenopathy present. liferative disorder that affects adults, and was first reported We decided to admit the patient in the ward to perform invasive exams such as a bone marrow aspiration which showed 66% of as a distinct disease in 1958 -
Localized AL Amyloidosis in a Patient with Diffuse Large B-Cell Lymphoma of the Breast
Included in the theme issue: 284 Letters to the Editor ACNE, RETINOIDS AND LYMPHOMAS Acta Derm Venereol 2012; 92: 284–285 Localized AL Amyloidosis in a Patient with Diffuse Large B-cell Lymphoma of the Breast Hsien-Yi Chiu, Chia-Yu Chu and Tsen-Fang Tsai* Department of Dermatology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan. *E-mail: [email protected] Accepted July 11, 2011. Amyloidosis refers to a variety of conditions in which a protein polysaccharide complex, amyloid protein, is accumulated locally or systemically in tissues or organs. Amyloid in the skin may be derived directly from kerati- nocytes, or secondarily from immunoglobulin light chain fragments (AL type), fragments of the acute-phase reac- tant serum amyloid A (AA type), etc. Nodular amyloido- sis (NA) is a rare type of localized AL amyloidosis, with most reported cases being of the lambda light chains (1) and is often histopathologically indistinguishable from systemic amyloidosis. Its association with lymphoma has been observed infrequently. CASE REPORT An 88-year-old woman initially noticed a 5×3 cm mass in her right breast in 1990. She was diagnosed with non-Hodgkin’s lymphoma (NHL) (diffuse large immunoblastic B-cell type, sta- ge IE) after the excision of the mass in a tertiary referral centre. Bone marrow biopsy revealed no evidence of lymphoma invol- vement. She achieved complete remission after chemotherapy. Six years after the diagnosis of lymphoma she developed multiple enlarging nodules on her legs. On examination, there were coalescing, waxy, skin-coloured, nodules with some foci of haemorrhage, central ulceration and crusts on the legs (Fig.