6/29/2015 SUBJECT: Phosmet: Data Evaluation Records

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6/29/2015 SUBJECT: Phosmet: Data Evaluation Records

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION MEMORANDUM Date: 6/29/2015 SUBJECT: Phosmet: Data Evaluation Records (DERs) for EDSP Tier 1 Assays PC Code: 059201 DP Barcode: D397165, D400672 Decision No.: 459049, 463273 Registration No.: NA Petition No.: NA Regulatory Action: NA Risk Assessment Type: NA Case No.: NA TXR No.: 0056199 CAS No.: 732-11-6 MRID No.: See Table 40 CFR: NA Ver.Apr. 2010 FROM: Greg Akerman, Ph.D. Do- ff--- lmmediate Office Health Effects Division (7509P) THROUGH: Jess Rowland ~- ~ Deputy Director Health Effects Division TO: Jolene Trujillo Biologist/Chemical Review Manager Risk Management and Implementation Branch V Pesticide Re-evaluation Division (7505P) I. ACTION REQUESTED The Pesticide Re-evaluation Division (PRD) of OPP has requested that the Health Effects Division (HED) review the Endocrine Disruptor Screening Program (EDSP) Tier 1 assays submitted in response to the agency's Test Order for phosmet: Test Order # EDSP-059201-54. Pagel of2 Page 1 of 260 II. RESPONSE Attached are the EDSP Tier 1 assay DERs for phosmet. III. MRID Table Chemical: Phosmet PC Code: 059201 Guideline Assay MRID 890.1100 Amphibian Metamorphosis Assay (Frog) 48673001 890.1150 Androgen Receptor Binding (Rat Prostate) 48618703 890.1200 Aromatase Assay (Human Recombinant) 48618702 890.1250 Estrogen Receptor Binding 48618704 890.1300 Estrogen Receptor Transcriptional Activation 48618705 (Human Cell Line HeLa-9903) 890.1350 Fish Short-Term Reproduction 48673002 890.1400 Hershberger (Rat) 48618706 890.1450 Female Pubertal (Rat) 48673003 890.1500 Male Pubertal (Rat) 48673003 890.1550 Steroidogenesis (Human Cell Line – H295R) 48618701 890.

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