Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000754405Cyc: Flavobacterium psychrophilum FPG3 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

phosphate phosphate phosphate phosphate

predicted ABC RS10325 RS01900 transporter RS10755 of phosphate

phosphate phosphate phosphate phosphate

Fatty Acid and Metabolic Regulator Lipid Degradation Carbohydrate Biosynthesis Degradation ditrans,octacis- a peptidoglycan with a nascent a [bis(guanylyl a peptidoglycan oleate β-oxidation a purine an N-modified an L-asparaginyl- an L-cysteinyl- [2Fe-2S] iron-sulfur , Carrier, and Vitamin Biosynthesis undecaprenyldiphospho- (L-alanyl-γ-D-glutamyl- adenosylcobinamide peptidoglycan molybdopterin) cys dimer (meso- superpathway of tetrahydrofolate biosynthesis superpathway of coenzyme A biosynthesis I (bacteria) NAD de novo biosynthesis adenosylcobinamide-GDP thiamine diphosphate ppGpp metabolism D-mannose ribonucleoside aminoacyl-[tRNA] [tRNA Asn ] [tRNA Cys ] dGDP cluster biosynthesis thiamine diphosphate TCA cycle TCA cycle I (prokaryotic) N-acetyl-(N-acetyl-β-D- L-lysyl-D-alanyl-D- (meso-DAP cofactor diaminopimelate II (from tryptophan) salvage from cobinamide I biosynthesis III biosynthesis II (Bacillus) oleate degradation alanine) pentapeptide 5'-triphosphate chaperone]- containing) ribonucleoside- 3-methyl-2- a 5,10- glucosaminyl)muramoyl- containing) (Staphylococcus) γ diphosphate L-cysteine desulfurase cob(II)inamide pppGpp acetyl-CoA D-mannopyranose L-alanyl- -D-glutamyl-L- L-cysteine aminoacyl- aminoacyl- aminoacyl- GTP oxobutanoate methylenetetrahydrofolate HMP-PP trp long-chain fatty bifunctional reductase cob(I)yrinic acid HMP-PP 6-phosphate lysyl-D-alanyl-D-alanine tRNA penicillin- tRNA tRNA thiamine tryptophan 2,3- bifunctional (p)ppGpp acid--CoA : class I mannose- adenosylcobinamide lytic subunit alpha: cysteine 3-methyl-2-oxobutanoate a,c-diamide thiamine menaquinol-7 biosynthesis : binding hydrolase: hydrolase: GTP phosphate dioxygenase: synthetase/guanosine- oxaloacetate FPG3_RS09065 6-phosphate kinase/ transglycosylase cysteine FPG3_RS02335 desulfurase: hydroxymethyltransferase: adenosyltransferase: phosphate guanosine 3'- arfB protein arfB arfB cyclohydrolase synthase: FPG3_RS01205 all-trans- 3',5'-bis(diphosphate) 3'- : monofunctional adenosylcobinamide- domain-containing desulfurase: FPG3_RS11525 panB N-Formyl-L- FPG3_RS05140 synthase: diphosphate 5'- citrate synthase: 2: mrdA ribonucleoside- I FolE: folE FPG3_RS02195 [corrinoid heptaprenyl 1,4-dihydroxy- pyrophosphohydrolase: oleoyl-CoA FPG3_RS08730 biosynthetic phosphate protein: FPG3_RS05750 aminoacyl-tRNA aminoacyl-tRNA aminoacyl-tRNA cysteine kynurenine FPG3_RS02195 triphosphate 3'- malate:quinone FPG3_RS02855 diphosphate asp adenosyltranferase]- diphosphate 2-naphthoate FPG3_RS08340 F6P peptidoglycan guanylyltransferase: FPG3_RS07600 cysteine hydrolase: hydrolase: hydrolase: desulfurase: GTP thiamine thiamine diphosphatase: : acyl-CoA reductase: cob(II)inamide transglycosylase: cobU endolytic desulfurase: FPG3_RS01215 a peptidoglycan FPG3_RS01215 FPG3_RS01215 FPG3_RS05750 cyclohydrolase 2-dehydropantoate phosphate FPG3_RS08340 FPG3_RS08905 dehydrogenase: FPG3_RS02340 aspartate 1- phosphate malate dehydrogenase: mtgA transglycosylase FPG3_RS11525 with D,D cross- D-ala I FolE: folE synthase: synthase: FPG3_RS03425 adenosyl- GDP an S-sulfanyl-[L- 7,8- decarboxylase: FPG3_RS04900 MltG: mltG links (meso- FPG3_RS02205 FPG3_RS02205 [+ 3 isozymes] cobinamide an N-modified an uncharged cysteine desulfurase] dihydroneopterin flavin biosynthesis I (bacteria and plants) FPG3_RS00585 thiamine L-kynurenine [corrinoid Secondary Metabolite Degradation a peptidoglycan with di-trans,octa-cis a purine a [bis(guanylyl diaminopimelate asn tRNA Asn cys a tRNA Cys thiamine demethylmenaquinol-7 GTP ppGpp (S)-malate citrate phosphate tRNA phosphate adenosyltranferase]- (2E,9Z)- (L-alanyl-γ-D-glutamyl- -undecaprenyl amino acid containing) 3'-triphosphate β phosphate ribonucleoside a mature a nascent ala molybdopterin) -alanine kynurenine 3- octadecenoyl-CoA diphosphate (R)-pantoate thiamine- cob(I)inamide bifunctional anhydromuropeptides recycling I L-lysyl-D-alanyl-D- 5'-diphosphate peptidoglycan peptidoglycan cofactor monooxygenase: GTP phosphate cob(I)yrinic acid demethylmenaquinone nucleoside- alanine) pentapeptide with (L-alanyl- (meso-DAP chaperone]-S- an S-sulfanyl-[cysteine FPG3_RS10790 fumarate hydratase: 7,8- pantoate--beta- kinase: thiL a,c-diamide methyltransferase/2- diphosphate GDP aconitate hydratase: GlcNAc-1,6- γ-D-glutamyl- containing) with sulfanyl-L-cysteine desulfurase]-[disordered- adenosyltransferase: kinase: pyrophosphokinase: bifunctional (p)ppGpp FPG3_RS08565 dihydroneopterin GTP alanine ligase: thiamine 3-hydroxy- thiamine methoxy-6-polyprenyl- FPG3_RS03555 (S)-3-hydroxy-(9Z) anhMurNAc- meso-2,6- GlcNAc terminus form scaffold FPG3_RS04585 synthetase/guanosine- γ 3'-phosphate cyclohydrolase FPG3_RS00590 L-kynurenine FPG3_RS05140 1,4-benzoquinol FPG3_RS08340 class II fumarate -octadecenoyl-CoA L-Ala- -D-Glu- diaminopimeloyl- protein] complex diphosphate 3',5'-bis(diphosphate) 3'- [cysteine desulfurase]-S- II: ribB thiamine methylase UbiE: ubiE hydratase: fumC DAP-D-Ala D-alanine) 2,5-diamino-6- kynureninase: adenosylcobinamide pyrophosphohydrolase: fumarate cis-aconitate 3-hydroxyacyl-CoA sulfanylcysteine:[acceptor diphosphokinase: dehydrogenase: tetrapeptide (5-phospho-D- (R)-pantothenate kynU menaquinol-7 FPG3_RS08340 aconitate hydratase: protein]-cysteine bifunctional FPG3_RS08835 FPG3_RS10310 D-erythro-7,8- chorismate ribosylamino) superpathway of thiamine diphosphate biosynthesis I GDP succinate dehydrogenase/ FPG3_RS03555 sulfurtransferase: pyrimidin- type III 3-hydroxyanthranilate adenosylcobinamide thiamine fumarate reductase 3-oxo-(9Z)- dihydroneopterin N-acetyl-β-D- L-alanyl-γ-D- UDP-N-acetyl-α-D-muramoyl- ditrans,octacis- a peptidoglycan a ribonucleoside a [protein] FPG3_RS05750 pantothenate kinase/ diphosphate D-alanyl-D-alanine an adenine in DNA a D-tyrosyl- aminodeoxychorismate/ 4(3H)-one iron-sulfur subunit: octadecenoyl-CoA γ a malonyl-[acp] a palmitoleoyl-[acp] undecaprenyldiphospho- dimer (generic) Tyr C-terminal glu a [cysteine desulfurase]- dihydroneopterin cys 3-hydroxyanthranilate glucosamine-1,6- glutamyl-meso-2,6- L-alanyl- -D-glutamyl-L-lysine diphosphate [tRNA ] dADP anthranilate synthase bifunctional kinase: adenosylcobinamide- FPG3_RS00510 acetyl-CoA C- N-acetyl-(N- type I restriction- L-glutamate S-sulfanyl-[disordered- aldolase: folB 3,4-dioxygenase: anhydro-N-acetyl- diaminopimeloyl- ribonucleoside- component II: diaminohydroxyphosphoribosylaminopyrimidine FPG3_RS11750 phosphate acyltransferase: β acetylglucosaminyl) modification ribonucleoside- form scaffold cysteine FPG3_RS10905 -D-muramate D-alanine lytic diphosphate 6-(hydroxymethyl) FPG3_RS04820 deaminase/5-amino-6-(5-phosphoribosylamino) (R)-4'- guanylyltransferase: succinate FPG3_RS09040 bifunctional UDP- muramoyl-L-alanyl-γ- system subunit M: diphosphate protein] complex desulfurase: 2-amino-3- Secondary Metabolite Biosynthesis D-threo-isocitrate glcNAc-1,6- LD- beta- transglycosylase reductase D-tyrosyl- 30S cysteine -7,8-dihydropterin uracil reductase RibD: ribD cobU N-acetylmuramoyl- β FPG3_RS04735 reductase 4-amino-4- phosphopantothenate carboxymuconate- isocitrate dehydrogenase acetyl-CoA C- anhMurNAcaminidase: carboxypeptidase: ketoacyl- D-isoglutaminyl-N-( - domain-containing subunit alpha: tRNA(Tyr) ribosomal desulfurase: 5-amino-6-(5- FPG3_RS11525 ADP-forming tripeptide:D-alanyl-D- subunit alpha: 2-amino-4-hydroxy-6- deoxychorismate bifunctional adenosyl-cobinamide (NADP(+)): FPG3_RS08310 acyltransferase: FPG3_RS05985 FPG3_RS00335 ACP D-asparaginyl)-L-lysyl- Dam family site- FPG3_RS02335 deacylase: phospho-D- cysteine 6-semialdehyde fluoroacetate and alanine ligase/alanine protein: protein FPG3_RS02335 FPG3_RS11525 hydroxymethyldihydropteridine phosphopantothenoylcysteine phosphate pyridoxal 5'-phosphate biosynthesis I preQ biosynthesis succinate--CoA ligase synthase D-alanyl-D-alanine specific DNA- FPG3_RS01305 0 FPG3_RS06045 1,6-anhydro-N- LD- FPG3_RS07600 ribonucleoside- S6--L- cysteine diphosphokinase: folK ribosylamino)uracil desulfurase: fluorothreonine biosynthesis subunit beta: sucC racemase: FPG3_RS10640 (adenine-N6)- ribonucleoside- decarboxylase/ bifunctional acetyl-β-muramate carboxypeptidase: II: fabF diphosphate glutamate (7,8-dihydropterin- D-ribulose bifunctional FPG3_RS05750 D-erythrose (7Z)-hexadecenoyl-CoA UDP-N-acetylmuramoyl- endolytic RS08685 fluoride desulfurase: phosphopantothenate-- succinate--CoA ligase FPG3_RS01775 monofunctional methyltransferase: reductase: ligase: rimK diphosphate 6-yl)methyl 5-phosphate diaminohydroxyphosphoribosylaminopyrimidine an [L-cysteine adenosylcobinamide fluoride anhydro-N- transglycosylase FPG3_RS05750 cysteine ligase CoaBC: coaBC 4-phosphate subunit alpha: sucD L-alanyl-γ-D- tripeptide--D-alanyl- FPG3_RS06440 Tyr reductase: 4-aminobenzoate desulfurase]-S- quinolinate GTP an (11Z)-3- biosynthetic 6 FPG3_RS02340 D-tyrosine a tRNA an S-sulfanyl-[cysteine diphosphate deaminase/5-amino-6-(5-phosphoribosylamino) kinase/ acyl-CoA acetylmuramic D- alanine ligase: MltG: mltG an N - a 2'- 3,4- (R)-4'- sulfanyl-L-cysteine SAM-dependent GTP succinyl-CoA 2-oxoglutarate glutamyl-meso- oxooctadec- acyl-carrier protein peptidoglycan FPG3_RS02340 desulfurase]-S- uracil reductase RibD: ribD adenosylcobinamide- dehydrogenase: acid kinase: FPG3_RS02435 methyladenine deoxyribonucleoside a [protein] C- dihydroxy-2- phosphopantothenoyl- carboxylating chlorinase/ cyclohydrolase diaminopimelate ADP a sugar RS02895 a sugar sulfanyl-[disordered- dihydropteroate 5-amino-6-(5- cysteine phosphate FPG3_RS03425 FPG3_RS08060 11-enoyl-[acp] transglycosylase: GlcNAc-1,6- in DNA 5'-diphosphate terminal α-L- butanone-4- phospho-D- L-cysteine a [ThiS sulfur- desulfurase: nicotinate- guanylyltransferase: 4-phospho- fluorinase: I FolE: folE N-acetyl-D- mtgA a lipid II α form scaffold synthase: folP [+ 3 isozymes] UDP-N-acetyl-α-D-muramoyl-L-alanyl- anhydro-MurNAc- glutamate- - phosphate ribitylamino)uracil bifunctional carrier protein] FPG3_RS11525 nucleotide cobU D-erythronate FPG3_RS03975 GTP muramate 6- protein] complex (2E,7Z)- γ pentapeptide L-glutamate [cysteine desulfurase]-S- synthase: phosphopantothenoylcysteine diphosphorylase: phosphate -D-glutamyl-L-lysyl-D-alanyl-D-alanine 2+ 2+ 7,8- ThiS cysteine 5'-deoxy-5'- cyclohydrolase a peptidoglycan di-trans,octa-cis Cu RS11585 Cu sulfanylcysteine:[acceptor ribB decarboxylase/ nadC adenosylcobinamide- 7,8- 2-oxoglutarate hexadecenoyl-CoA dihydropteroate adenylyltransferase: desulfurase: fluoroadenosine I FolE: folE N-acetylmuramic dimer (E. faeciums) -undecaprenyl protein]-cysteine 1-deoxy-L- phosphopantothenate-- GDP dehydrogenase E1 FPG3_RS02220 FPG3_RS05750 purine-nucleoside dihydroneopterin acid 6- diphosphate sulfurtransferase: bifunctional glycero-tetrulose cysteine ligase CoaBC: coaBC NaMN (3R)-3-hydroxy-2-oxo- component: FPG3_RS11620 ARP adenosylcobalamin a carboxy- a [ThiI sulfur- phosphorylase: 3'-triphosphate phosphate FPG3_RS05750 folylpolyglutamate 4-phosphate 4 phosphooxybutanoate Cd 2+ RS02180 Cd 2+ a [cysteine salvage from cobalamin D-glyceraldehyde adenylated-[ThiS carrier protein]-S- nicotinate-nucleotide FPG3_RS04265 6-carboxytetrahydropterin (S)-3-hydroxy-(7Z) etherase: murQ synthase/ 4'-phosphopantetheine ditrans,octacis- a [ThiI sulfur- DNA with adenine:7,8- a peptidoglycan a protein-L- desulfurase]-(S- 3-phosphate sulfur-carrier protein] sulfanyl-L-cysteine adenylyltransferase: D-glyceraldehyde 3-phosphoserine/ synthase: FPG3_RS10965 -hexadecenoyl-CoA N-acetyl-D- quinoxaline-2- a [protein]- dihydrofolate 6,7-dimethyl-8- pyruvate 5-fluoro-5-deoxy-D- glucosamine a 5,10-gly a uridine 34 aryl-carrier protein undecaprenyldiphospho- carrier protein]- cys dihydro-8- dimer (E. faeciums) a glycyl-[tRNA Ala ] L-tyrosine methionine- sulfanyl) -[disordered- cob(I)alamin pantetheine- FPG3_RS00770 3-phosphate phosphohydroxythreonine carboxyl adenylate 2 synthase: ribityllumazine 1-deoxy-D- tyr ribose 1-phosphate 6-carboxy-5,6,7,8- 3-hydroxyacyl-CoA methylenetetrahydrofolate in tRNA N-acetyl-(N- L-cysteine oxoguanine mismatch polysaccharide (R)-S-oxide form scaffold adenylate:persulfide transaminase: serC Respiration 6-phosphate peptide- an anion RS04110 an anion FPG3_RS04965 synthase: phosphate xylulose-5- nicotinate adenine tetrahydropterin dehydrogenase: biosynthesis protein] complex : 4-phosphooxy- acetylglucosaminyl) penicillin- adenylyltransferase: AIR phosphate 2-iminoacetate dinucleotide 1-deoxy-D- 7-carboxy-7- FPG3_RS10310 tyrosine methionine 7,8-dihydrofolate FPG3_RS07660 FPG3_RS02220 L-threonine tRNA uridine-5- acyl carrier muramoyl-L-alanyl- cysteine A/G-specific binding D-tyrosyl- cob(II)alamin coaD synthase: synthase xylulose-5- 2-oxoglutarate decarboxylation to succinyl-CoA (R)-S-oxide monoglutamate 5-fluoro-5-deoxy-D- deazaguanine 3-oxo-(7Z)- carboxymethylaminomethyl(34) protein: γ-D-isoglutaminyl- desulfurase: adenine protein tRNA(Tyr) autokinase: 3'-dephospho- phosphomethylpyrimidine FPG3_RS01505 ThiH: thiH phosphate 4-hydroxythreonine- D-glucosamine reductase 6,7-dimethyl-8-(1- a thiocarboxylated- ribulose 1-phosphate synthase QueE: a [2-oxoglutarate hexadecenoyl-CoA synthesis MnmG: mnmG FPG3_RS01060 N-(β-D-asparaginyl) FPG3_RS05750 glycosylase: 2: mrdA deacylase: FPG3_RS02900 chloride RS08805 chloride cob(I)yrinic acid CoA synthase ThiC: thiC synthase: 4-phosphate FPG3_RS10730 6-phosphate MsrB: msrB a [cysteine desulfurase]- D-ribityl)lumazine 1-deoxy-D-xylulose 2-iminoacetate [ThiS sulfur- dehydrogenase acetyl-CoA C- [+ 2 isozymes] -L-lysyl-D-alanine mutY FPG3_RS01305 polysaccharide a,c-diamide + FPG3_RS01505 dehydrogenase tRNA uridine-5- cysteine [scaffold protein- riboflavin dephospho- 5-phosphate carrier protein] NAD 7-carboxy-7- 6 acyltransferase: phosphoglucosamine peptide- adenosyltransferase: HMP-P PdxA: pdxA E2 protein] N 2-oxoglutarate carboxymethylaminomethyl(34) desulfurase: a peptidoglycan biosynthesis (2Fe-2S)] complex CoA kinase: mutase: glmM methionine a 7,8-dihydrofolate synthase: 3-amino-1- deazaguanine -lipoyl-L-lysine dehydrogenase FPG3_RS09040 synthesis GTPase MnmE: mnmE monofunctional FPG3_RS11525 tetramer with a D-ala tyrosine FPG3_RS05140 FPG3_RS08520 thiazole synthase: 1-deoxy-D- a quinoxaline-2- an apurinic site (R)-S-oxide potassium- FPG3_RS11495 hydroxymethylpyrimidine/ α Ala autokinase: cob(II)alamin- thiamine diphosphate salvage II xylulose 5- hydroxyacetone fluoroacetaldehyde 2-oxoglutarate E1 component: acetyl-CoA C- -D-glucosamine carboxyl-[aryl- biosynthetic D,D cross-link a tRNA gly + + dihydrofolate FPG3_RS02210 Storage Compound AMP adenine within DNA reductase K transporting K [corrinoid coenzyme A phosphomethylpyrimidine phosphate 1-phosphate dehydrogenase FPG3_RS11620 acyltransferase: 1-phosphate peptidoglycan (Enterococcus FPG3_RS03005 reductase: riboflavin Biosynthesis a 5-carboxymethylaminomethyluridine 34 carrier protein] a [ThiI sulfur- a [protein]- MsrB: msrB ATPase a [co-chaperone]- adenosyltranferase] kinase: FPG3_RS02200 bis(guanylyl molybdopterin) 4-amino-2-methyl-5- E1 component: FPG3_RS06045 a 7,8-dihydrofolate a [protein]-L- FPG3_RS01725 2-[(2R,5Z)-2-carboxy- thiamine in tRNA transglycosylase: ala carrier protein]- faecium) L-tyrosine [scaffold protein- bifunctional 4-methylthiazol-5(2H)- cofactor sulfurylation pyrimidinemethanol pyridoxine 5'- preQ cyanophycin metabolism FPG3_RS11620 mtgA methionine HMP-PP diphosphate 0 (5Z)-tetradecenoyl-CoA S-sulfanyl- phosphate (2Fe-2S)] complex phosphate lys RS01925 lys a tetrahydrofolate riboflavin kinase/ ylidene]ethyl phosphate hydroxymethylpyrimidine/ salvage III [+ 2 isozymes]a [2-oxoglutarate a [2-oxoglutarate N-acetyl-α-D- L-cysteine FAD synthetase: cob(I)alamin- cys phosphomethylpyrimidine synthase: dehydrogenase dehydrogenase acyl-CoA di-trans,octa-cis thiamine fluoroacetate asp glucosamine a peptidoglycan bacillithiol biosynthesis kinase: FPG3_RS02200 FPG3_RS07200 4-fluorothreonine 6 6 FPG3_RS01230 [corrinoid thiamine thiamine E2 protein] N E2 protein] N -S- dehydrogenase: 1-phosphate dimer (E. faecium -undecaprenyl a [chaperone-ATP]- adenosyltranferase] phosphate cysteine 5-(2-hydroxyethyl) -dihydrolipoyl- succinyldihydrolipoyl- FPG3_RS08055 diphosphate FMN HMP-P diphosphokinase: cyanophycin , tetrapeptide) [co-chaperone]- cob(I)yrinic acid (S)-malate UDP-N-acetyl- synthase: desulfurase: -4-methylthiazole pyridoxine L-lysine L-lysine [+ 3 isozymes] α FPG3_RS08835 synthetase: [scaffold protein- a,c-diamide -D-glucosamine FPG3_RS02195 FPG3_RS11525 hydroxymethylpyrimidine/ 5'-phosphate thiamine bifunctional cphA (2E,5Z)- UDP-N-acetyl- a [ribosomal α-Kdo-(2->4) L-alanyl-γ-D- (2Fe-2S)] complex adenosyltransferase: thiamine cysteine phosphomethylpyrimidine pyridoxamine diphosphate a sulfurated a nucleoside riboflavin kinase/ tetradecenoyl-CoA α-D-glucosamine protein S12] α 2-oxoglutarate isochorismate H O glutamyl-L-lysyl- sec folate transformations III (E. coli) N-acetyl- arg cyanophycin dGTP - -Kdo-(2->6) a myristoyl-[acp] 2 GTP triphosphate RNA ATP roseoflavin ser a tRNA FAD synthetase: FPG3_RS05140 phosphate desulfurase: kinase: FPG3_RS02200 5'-phosphate 2-oxoglutarate [sulfur carrier] 89 alpha-D- 4-methyl-5-(2- primer-L-aspartate UDP-N-acetylglucosamine L-aspartate -(lauroyl)-lipid D-alanyl-D-alanine 5'-phosphate adenosylcob(III) synthase: FPG3_RS05750 oxidase: pdxH dehydrogenase FPG3_RS01230 glucosaminyl phosphooxyethyl) 1-carboxyvinyltransferase: IV (E. coli) a tetrahydrofolate alamin-[corrinoid an [L-cysteine HMP-PP A FPG3_RS02205 thiazole E1 component: murA 2-succinyl-5- a [chaperone- FAD adenosyltranferase] L-malate desulfurase]-S- PLP cyanophycin 30S ribosomal GTPase Era: DNA-directed penicillin- serine- an [2Fe-2S] FPG3_RS11620 (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) α deoxyguanosinetriphosphate enolpyruvyl- bifunctional ADP]-[disordered- cob(I)yrinic acid synthase sulfanyl-L-cysteine synthetase: UDP-N-acetyl- - protein S12 lipid A FPG3_RS07875 RNA polymerase binding -tRNA cluster protein thiamine triphosphohydrolase: 6-hydroxy-3- form scaffold a,c-diamide BshA: bshA thiamine phosphate cysteine cphA 2-oxoglutarate 3,5-dienoyl-CoA -tetradecenoyl-CoA D-glucosamine- methylthiotransferase biosynthesis subunit omega: protein riboflavin kinase/ ligase: phosphate FPG3_RS01520 cyclohexene-1- [+ 5 isozymes] protein] complex adenosyltransferase: desulfurase: dehydrogenase acyl-CoA 3-hydroxyacyl-CoA enolpyruvate RimO: rimO acyltransferase: FPG3_RS08475 2: mrdA FAD synthetase: serS (S)-malyl N- thiamine- bis(guanylyl synthase: complex thioesterase: dehydrogenase: carboxylic-acid FPG3_RS01230 F0F1 ATP FPG3_RS05140 FPG3_RS11525 asp UDP-N- FPG3_RS11145 [+ 2 isozymes] + + dihydrofolate cyanophycin synthase: menD + H H acetyl-α-D- phosphate molybdopterin) FPG3_RS02195 dihydrolipoyllysine- FPG3_RS07725 FPG3_RS10310 phosphate H γ synthase reductase: cysteine 2-methyladeninyl adenosylcobamide acetylmuramate a [ribosomal GDP L-alanyl- -D- adenosylcobalamin glucosaminide kinase: thiL cofactor thiamine Aromatic Compound Biosynthesis residue an unsulfurated triphosphate lipid A roseoflavin an L-seryl- FPG3_RS01725serine desulfurase: biosynthesis from adenosylcobinamide-GDP [+ 5 isozymes] 3-oxo-(5Z)- dehydrogenase: 5'-deoxyadenosine met protein S12]-3- 2'-deoxyguanosine glutamyl-L- D-ala an [Fe-S cluster bacillithiol biosynthesis 2-succinyl-5-enolpyruvoyl- [tRNA sec ] a 5-methyltetrahydrofolate phosphate cyanophycin succinyltransferase: (3E,5Z)- tetradecenoyl-CoA murB methylsulfanyl- [sulfur carrier] RNA lysyl-D-alanine adenine biosynthesis a 7,8-dihydrofolate hydroxymethyltransferase: bifunctional biosynthesis thiamine diphosphate FPG3_RS05750 acyltransferase: 6-hydroxy-3-cyclohexene- synthase: chorismate biosynthesis I synthetase: odhB 89 dinucleotide F0F1 ATP glycine cleavage system a [bis(guanylyl 2-methyladenine tetradecadienoate acetyl-CoA C- UDP-N-acetyl- L-aspartate + + chaperone]-ATP FPG3_RS05605 5,10-methylene- deacetylase dipicolinate biosynthesis FPG3_RS06155 1-carboxylate H H aminomethyltransferase molybdopterin) [bis-MGD FPG3_RS02205 cphA acyltransferase: α-D-muramate synthase thymidylate tetrahydrofolate a (6S)-5- BshB1: bshB1 D-erythrose GcvT: gcvT cofactor cofactor nicotinate-nucleotide-- synthase: dehydrogenase/ formyltetrahydrofolate FPG3_RS06045 α-D-Kdo-(2->4) (S)-malyl α-D- chaperone]-S- thiamine dimethylbenzimidazole 4-phosphate asp arg [cyanophycin]- FPG3_RS01740 [+ 2 isozymes] chaperone]- bifunctional 3-deoxy-7- acetyl-CoA C- α 5,10-methylene-5-formyltetrahydrofolate phosphoribosyltransferase: 2-oxoisovalerate decarboxylation to isobutanoyl-CoA acyl-carrier protein - -D-Kdo-(2->6) + + glucosaminide sulfanyl-L-cysteine bis-MGD phosphate phosphoheptulonate aspartate kinase: L-aspartate H RS10780 H tetrahydrofolatecyclo-ligase: adeninyl adenosylcobamide biosynthesis cobT acyltransferase: UDP-N-acetyl- -lipid A (E. coli) bacillithiol thiamine- synthase/chorismate FPG3_RS01345 cyclohydrolase:FPG3_RS01165 from adenosylcobinamide-GDP an [apo BCAA FPG3_RS09040 α-D-muramoyl- biosynthesis mutase type II: aspartate kinase: cyanophycin FPG3_RS04250 phosphate dehydrogenase (3Z)-dodec- L-alanyl-γ-D- a 5,10- a 5,10- 2-methyladenine synthetase: alpha-ketoacid 34 (1S,2R)-1- cysteine- kinase: thiL FPG3_RS01315 FPG3_RS01590 E2 protein] N 6 a 5,10- a 2-thiouridine an N-terminal ditrans,octacis- phosphoenol a D-aspartyl- + + adenosylcobinamide- ribotide phosphate 3-deoxy- L-aspartyl- cphA dehydrogenase 3-enoyl-CoA glutamyl-meso-2,6- an L-phenylalanyl- O-succinyl-L- H RS04970 H methylenetetrahydrofolate methenyltetrahydrofolate adding adenine sulfo-bis(guanylyl methylenetetrahydrofolate in tRNA Phe undecaprenyldiphospho- ser C-(indol-3- asp a protein benzimidazolyl adenosylcobamide thiamine D-arabino- -lipoyl-L-lysine diaminopimelate L-lysyl-[protein] [tRNA ] homoserine dGDP pyruvate [tRNA ] ATP enzyme molybdopterin) GDP 4-phosphate subunit N-acetyl-(N- yl)glycerol biotin bifunctional biosynthesis from adenosylcobinamide-GDP diphosphate heptulosonate dihydrolipoyl ATP- BshC: bshC cofactor alpha/beta: acetylglucosaminyl) 3-phosphate 5,10-methylene- nicotinate-nucleotide-- 7-phosphate aspartate- cyanophycin dehydrogenase: tRNA uridine-5- dependent a metal a metal adenosylcobinamide- FPG3_RS05800 leucyl/ muramoyl-L-alanyl-γ-D- cystathionine D-tyrosyl- RS07495 tetrahydrofolate dimethylbenzimidazole benzimidazole semialdehyde lpdA (2E)-dodec- carboxymethylaminomethyl(34) Clp protease cation cation bacillithiol GDP 3-dehydroquinate cyanophycinase: dehydrogenase: phenylalanyl- isoglutaminyl-L-lysyl- tryptophan gamma-synthase: tRNA(Tyr) biotin--[acetyl- 5-methoxy-6-methylbenzimidazolyl adenosylcobamide dehydrogenase/ phosphoribosyltransferase: dehydrogenase: dihydrolipoyl 2-enoyl-CoA synthesis enzyme MnmG: mnmG pyruvate ATP-binding ribazoletransferase: synthase: aroB tRNA--protein (glycyl) -D-alanyl-D-alanine synthase: CoA-carboxylase] biosynthesis from adenosylcobinamide-GDP 5,10-methylene- cobT nicotinate-nucleotide-- FPG3_RS04880 FPG3_RS03825 FPG3_RS10465 5 FPG3_RS01850 kinase: pyk deacylase: subunit superpathway of heme b biosynthesis from uroporphyrinogen-III FPG3_RS04325 dehydrogenase: tRNA uridine-5- transferase: FPG3_RS04795 ligase: tetrahydrofolate dimethylbenzimidazole β FPG3_RS01305 ClpX: clpX 5-methoxy-6- 3-dehydroquinate L-aspartate 4- N- -aspartyl- lpdA an [apo BCAA an [apo BCAA dehydrogenase carboxymethylaminomethyl(34) trpB a metal a metal cyclohydrolase: adenine ribotide phosphoribosyltransferase: FPG3_RS11340 FPG3_RS05225 RS08330 α α 6 monofunctional cation methylbenzimidazole adenosylcobinamide- Co -[ -(2- semialdehyde L-arginine dehydrogenase E2 protein] N -S-[2- synthesis GTPase MnmE: mnmE a peptide cation FPG3_RS04250 phosphate cobT uroporphyrinogen-III type II 3- (S)-3- L-homocysteine succinate nicotinate-nucleotide-- 5-hydroxybenzimidazolyl adenosylcobamide methyladenin-9-yl)]-Co E2 protein] N 6 - methylpropanoyl]dihydrolipoyl- biosynthetic D-glyceraldehyde pyruvate GDP benzimidazole 4-hydroxy- hydroxydodecanoyl-CoA L-phenylalanyl- asp adenosylcobalamin biosynthesis an N 10 - biosynthesis from adenosylcobinamide-GDP β dehydroquinate peptidoglycan trp dGTP tRNA D-aspartate biotinyl-5'- dimethylbenzimidazole -adenosylcobamide biotin biosynthesis from dihydrolipoyl-L-lysine L-lysine a tRNA Phe 3-phosphate adenosylcobinamide- ribotide uroporphyrinogen dehydratase: aroQ tetrahydrodipicolinate 3-hydroxyacyl-CoA a 5-aminomethyl-2- L-lysyl-[protein] phosphoribosyltransferase: from adenosylcobinamide-GDP I formyltetrahydrofolate 5'-phosphate 8-amino-7-oxononanoate I a 7,8-dihydrofolate transglycosylase: adenylate a metal a metal adenosylcobinamide- GDP phosphate synthase: dehydrogenase: thiouridine 34 in tRNA RS12015 cobT 5-hydroxybenzimidazole NaMN decarboxylase: hemE alpha-ribazole mtgA cation cation GDP (8S)-8-amino-7- 3-dehydroshikimate FPG3_RS08485 FPG3_RS10310 5-methoxy-6- 5,6-dimethylbenzimidazole phosphatase: arg asp ribazoletransferase: adenosylcobinamide- coproporphyrinogen III oxononanoate (2S,4S)-4- adenosylcobinamide- methylbenzimidazole nicotinate-nucleotide-- cobC adenosylmethionine- hydroxy-2,3,4,5- 2-oxo acid 3-oxododecanoyl-CoA a peptidoglycan di-trans,octa-cis nicotinate-nucleotide-- FPG3_RS04325 GDP Coα-[α-(2- a metal a metal GDP ribotide phosphate -8-amino-7- tetrahydrodipicolinate dehydrogenase dimer (S. aureus) -undecaprenyl dimethylbenzimidazole dimethylbenzimidazole ribazoletransferase: methyladenin-7-yl)]-Co RS02255 Coα-[α-(adenin-9-yl)]- oxygen-dependent oxygen-independent oxononanoate subunit E2: acetyl-CoA C- diphosphate cation cation phosphoribosyltransferase: phosphoribosyltransferase: FPG3_RS04325 β-adenosylcobamide adenosylcobinamide- Coβ-adenosylcobamide coproporphyrinogen coproporphyrinogen transaminase: bioA shikimate FPG3_RS05175 acyltransferase: cobT cobT (7R,8S)- GDP 5'-phosphate oxidase: hemF III oxidase: hemN FPG3_RS09040 Coα-[α- α 2+ 2+ α diaminononanoate dipicolinate UDP-N-acetyl- -D-muramoyl- UDP-N-acetylmuramoyl-L- N-acetyl-muramoyl-(L- phosphoenol Nα,Nε-diacetyl-lysyl- dCDP Mg Mg ribazoletransferase: adenosylcobinamide- -ribazole alpha-ribazole shikimate kinase: acetyl-CoA C- di-trans,octa-cis- γ a peptide with a carbonic acid RS02120 5-hydroxybenzimidazole (benzimidazolyl)]-Co L-alanyl-γ-D-glutamyl-L- alanyl-γ-D-glutamyl-meso-2,6- GGPP GGGP alanyl- -D-glutamyl-L- D-alanyl-D-alanine 2+ 2+ FPG3_RS04325 5'-phosphate dethiobiotin FPG3_RS04405 acyltransferase: undecaprenyl phosphate leader sequence dADP pyruvate ribonucleoside- Co Co GDP adenosylcobinamide-GDP ribotide phosphate phosphatase: β-adenosylcobamide protoporphyrinogen IX protoporphyrinogen IX lysyl-D-alanyl-D-alanine diaminopimeloyl-D-alanine lysyl-D-alanyl-D-alanine) synthase: bioD diphosphate cobC 5'-phosphate shikimate 3- FPG3_RS06045 Coα-[α-(5-methoxy-6- carbonate adenosylcobinamide- Coα-[α-(adenin-7-yl)]- alpha-ribazole 5-methylbenzimidazolyl adenosylcobamide Glycolysis penicillin- reductase adenosylcobinamide- dethiobiotin phosphate Tetrapyrrole Biosynthesis decanoyl-CoA phospho-N- LD-carboxypeptidase: geranylgeranylglycerol- penicillin- signal Co 2+ Co 2+ methylbenzimidazolyl)]- GDP β phosphatase: protoporphyrinogen biosynthesis from adenosylcobinamide-GDP binding subunit alpha: dehydratase: RS08780 Co -adenosylcobamide acetylmuramoyl- phosphate 2+ 2+ Coβ-adenosylcobamide GDP ribazoletransferase: oxidase: FPG3_RS00280 3-phosphoshikimate 1- FPG3_RS00335 binding peptidase pyruvate protein FPG3_RS02335 can Mg Mg ribazoletransferase: cobC biotin acyl-CoA pentapeptide- geranylgeranyltransferase: 5'-phosphate FPG3_RS04325 Coα-[α- 5-methylbenzimidazole carboxyvinyltransferase: tetrapyrrole biosynthesis glycolysis I (from glucose 6-phosphate) LD-carboxypeptidase: protein I: lepB kinase: pyk 2: mrdA FPG3_RS04325 synthase dehydrogenase: transferase: FPG3_RS01655 ribonucleoside- alpha-ribazole (benzimidazolyl)]-Co FPG3_RS01270 I (from glutamate) FPG3_RS01775 2: mrdA heme b biosynthesis protoporphyrin IX BioB: bioB 5-enolpyruvoyl- FPG3_RS03425 FPG3_RS07355 diphosphate phosphatase: Coα-[α-(5-hydroxybenzimidazolyl)]- β-adenosylcobamide nicotinate-nucleotide-- D-glucopyranose 6-phosphate geranylgeranylglycerol- CO H O Mg 2+ RS00375 Mg 2+ adenosylcobalamin I (aerobic) 5-methoxybenzimidazolyl adenosylcobamide dimethylbenzimidazole shikimate 3- [+ 3 isozymes] phosphate Nα,Nε-diacetyl- reductase: 2 2 cobC Coβ-adenosylcobamide 5'-phosphate 9-mercaptodethiobiotin UDP-N-acetyl-α-D-muramoyl- N-acetyl-muramoyl-(L- a leader sequence a peptide pyruvate Coα-[α-(5-methoxy-6- 5'-phosphate biosynthesis from adenosylcobinamide-GDP heme a biosynthesis phosphoribosyltransferase: phosphate glu lysyl-D-alanine D-ala FPG3_RS02340 ferrochelatase: hemH undecaprenyl-diphospho-N- UMP D-ala L-alanyl-γ-D-glutamyl- geranylgeranyltransferase: alanyl-γ-D-glutamyl- D-ala dATP methyl-benzimidazolyl)]- uroporphyrinogen-III alpha-ribazole chorismate glutamyl-tRNA glucose-6-phosphate (2E)-dec-2-enoyl-CoA CDP alpha-ribazole cobT biotin acetylmuramoyl-L-alanyl-γ-D- meso-2,6-diaminopimelate FPG3_RS04525 L-lysyl-D-alanine) Coβ-adenosylcobamide uroporphyrinogen phosphatase: cobC 5-methoxybenzimidazole synthase: synthetase: isomerase: pgi Peptide RS11265 Peptide phosphatase: dipyrromethane protoheme protoheme 5-methylbenzimidazole synthase glutamyl-L-lysyl- D-alanyl-D-alanine decarboxylase: hemE aroC FPG3_RS00060 cobC Coα-[α-(5-hydroxybenzimidazolyl) nicotinate-nucleotide-- cofactor biosynthesis protoheme IX adenosylcobinamide-GDP ribotide phosphate BioB: bioB 2,3-bis-O- coproporphyrinogen III glutamate-- S-adenosyl-L- ]-Coβ-adenosylcobamide dimethylbenzimidazole : chorismate (geranylgeranyl) methionine salvage II adenosylcobalamin an apo-[hydroxymethylbilane cyoE biotin tRNA ligase: F6P (S)-3- oxygen-dependent phosphoribosyltransferase: adenosylcobinamide- -sn-glycerol Peptide RS11270 Peptide thioredoxin synthase]-L-cysteine ferroheme o an L-glutamyl-FPG3_RS00055 hydroxydecanoyl-CoA coproporphyrinogen cobT GDP 1-phosphate pathway Glu 3-hydroxyacyl-CoA SAH oxidase: hemF [tRNA ] class 1 fructose- 6-phosphofructokinase: 5-methoxybenzimidazole a [hydroxymethylbilane heme A synthase: ribazoletransferase: dehydrogenase: adenosylcobinamide-GDP glutamyl- bisphosphatase: fbp pfkA an N-terminal- an oxidized adenosylhomocysteinase: menaquinol-10 biosynthesis ribotide phosphate synthase] ES intermediate FPG3_RS09435 FPG3_RS04325 FPG3_RS10310 UDP-N-acetyl-α-D- N-acetyl-D-glucosaminyl-N- lipid II (meso UDP sulfite RS03570 sulfite protoporphyrinogen IX 2 di-trans,octa-cis- a D-aminoacyl- a D-tryptophanyl- O-phospho- acetyl-CoA thioredoxin FPG3_RS01005 cytidylyl molybdenum tRNA muramoyl-L-alanyl-γ-D- acetylmuramoyl-L-alanyl-D-glutamyl- diaminopimelate L-methionyl-L- cys α α undecaprenyl phosphate [tRNA] [tRNA Trp ] L-homoserine all-trans- hydroxymethylbilane Co -[ -(5-methylbenzimidazolyl) menaquinol-11 biosynthesis cofactor sulfurylation reductase: 3-oxodecanoyl-CoA 6-carboxy-L-lysyl-D-alanine cysteinyl-[protein] ribonucleoside- acetyl-CoA L-homocysteine protoporphyrinogen adenosylcobinamide- ferroheme i β β glutamyl-L-lysyl-D-alanine containing) decaprenyl 1,4-dihydroxy- synthase: hemC ]-Co -adenosylcobamide hemA DHAP -D-fructose 1,6-bisphosphate diphosphate oxidase: GDP ribazoletransferase: cytidylyl molybdenum carboxylase diphosphate 2-naphthoate 5'-phosphate all-trans- acetyl-CoA C- reductase sulfite RS08595 sulfite thioredoxin- FPG3_RS00280 FPG3_RS04325 a [hydroxymethylbilane heme A synthase: cofactor (trioxo) (S)-4-amino-5- LD-carboxypeptidase: peptidoglycan D-tyrosyl- type I methionyl cystathionine biotin undecaprenyl 1,4-dihydroxy- class II fructose- acyltransferase: phospho-N- D-tyrosyl- subunit alpha: disulfide synthase] ES intermediate FPG3_RS09435 folate polyglutamylation alpha-ribazole oxopentanoate aminopeptidase: gamma-synthase: carboxylase 3 2-naphthoate triose-phosphate bisphosphate acetylmuramoyl- FPG3_RS00335 synthetase: tRNA(Tyr) tRNA(Tyr) reductase: protoporphyrin IX phosphatase: cobC diphosphate FPG3_RS09040 FPG3_RS02335 subunit: accC Coα-[α-(5-methoxybenzimidazolyl)]- hydroxymethylbilane an [MCD cofactor glutamate-1- isomerase: aldolase: fbaA pentapeptide- LD-carboxypeptidase: FPG3_RS02635 deacylase: map deacylase: FPG3_RS01850 trxB hydroxyferroheme i α α acetyl-CoA C- ribonucleoside- a reduced Coβ-adenosylcobamide 5'-phosphate a tetrahydrofolate Co -[ -(5-methylbenzimidazolyl) semialdehyde FPG3_RS04475 transferase: FPG3_RS01775 FPG3_RS01305 FPG3_RS01305 [+ 3 isozymes] met ferrochelatase: synthase: hemC chaperone]-MCD acyltransferase: monofunctional diphosphate H O c-type DMKH2-10 ]-Coβ-adenosylcobamide 2,1- FPG3_RS07355 malonyl-CoA 2 hemH a [hydroxymethylbilane cysteine FPG3_RS06045 biosynthetic an N-terminal L- reductase: cytochrome cytochrome methionine alpha-ribazole aminomutase: N-acetyl-D-glucosaminyl-N- met oxidase an oxidized a reduced synthase] ES intermediate bifunctional serine desulfurase: peptidoglycan an uncharged cysteinyl-[protein] L-cystathionine FPG3_RS02340 adenosyltransferase: bifunctional phosphatase: cobC 4 DMKH2-11 hemL D-glyceraldehyde 3-phosphate undecaprenyl-diphospho-N Trp O c-type protoheme octanoyl-CoA UMP acetylmuramoyl-L-alanyl-D- D-ala transglycosylase: a D-amino acid D-tryptophan a tRNA 2 thioredoxin demethylmenaquinone folylpolyglutamate hydroxymethyltransferase: FPG3_RS11525 tRNA dUDP a reduced FPG3_RS01445 Coα-[α-(5-methoxybenzimidazolyl) hydroxymethylbilane ferroheme a -acetylmuramoyl-L-alanyl-γ- glutamyl-6-carboxy-L-lysine mtgA cytochrome methyltransferase/2- synthase: hemC synthase/ FPG3_RS05605 an N 10 - bifunctional cysteine 5-aminolevulinate H O c-type ]-Coβ-adenosylcobamide type I glyceraldehyde- acyl-CoA D-glutamyl-L-lysyl- D-alanine 2 dihydrofolate desulfurase: cytochrome SAM methoxy-6-polyprenyl- a holo-[hydroxymethylbilane formyltetrahydrofolate demethylmenaquinone 3-phosphate dehydrogenase: RS01970 an oxidized synthase: a 5,10- FPG3_RS05750 porphobilinogen lipid II (meso di-trans,octa-cis 1,4-benzoquinol synthase] bifunctional methyltransferase/2- dehydrogenase: gap FPG3_RS03425 O c-type FPG3_RS04965 methylenetetrahydrofolate a [cytidylyl molybdenum synthase: hemB diaminopimelate -undecaprenyl 2 lipoate biosynthesis demethylmenaquinol- methylase UbiE: ubiE folylpolyglutamate methoxy-6-polyprenyl- [+ 2 isozymes] [+ 3 isozymes] cytochromea reduced bifunctional cofactor chaperone]- containing) diphosphate and incorporation I 8 biosynthesis I synthase/ 1,4-benzoquinol H O cytochrome- c-type menaquinol-10 menaquinol-8 biosynthesis menaquinol-9 biosynthesis folylpolyglutamate methylase UbiE: ubiE cytidylyl molybdenum porphobilinogen (2E)-oct-2-enoyl-CoA 2 a tetrahydrofolate dihydrofolate c oxidase, ancytochrome oxidized all-trans- synthase/ cofactor (sulfo-dioxo) 13-DPG 7,8- an N-terminal- an unstable menaquinol-6 biosynthesis an octanoyl-[acp] 1,4-dihydroxy- synthase: an N-terminal an N-terminal- a mismatched cbb3-type octaprenyl menaquinol-11 hydroxymethylbilane an L-phenylalanyl- 34 O c-type dihydrofolate ala a pimeloyl-[acp] glu a (6S)-5- dihydroneopterin L-methionyl-L- L-methionyl-L- a cytidine lys RecA filament- 2 FPG3_RS04965 Phe DNA base pair lipoyl(octanoyl) 2-naphthoate diphosphate demethylmenaquinol-8 demethylmenaquinol-9 arginyl-[protein] [tRNA ] Ile2 a cytochromereduced synthase: synthase: hemC formyltetrahydrofolate 3'-triphosphate threonyl-[protein] DNA mismatch valyl-[protein] in tRNA DNA complex demethylmenaquinol-6 transferase bifunctional bifunctional an N 10 - phosphoglycerate DNA H O c-type FPG3_RS04965 repair 2 LipB: lipB 1,4-dihydroxy- NADP demethylmenaquinone demethylmenaquinone formyltetrahydrofolate preuroporphyrinogen (S)-3- repair RS09945 cytochrome bifunctional a [lipoyl-carrier protein] kinase: FPG3_RS00140 leucyl/ protein MutS: an oxidized 2-naphthoate biosynthesis methyltransferase/2- methyltransferase/2- a 5,10- hydroxyoctanoyl-CoA 8-amino-7- bifunctional 6-pyruvoyl type I methionyl type I methionyl tRNA protein demethylmenaquinone N 6 -octanoyl-L-lysine phenylalanyl- FPG3_RS10520 O c-type methylenetetrahydrofolate uroporphyrinogen- 3-hydroxyacyl-CoA oxononanoate folylpolyglutamate tetrahydrobiopterin aminopeptidase: aminopeptidase: lysidine(34) RecO: 2 methyltransferase/2- octaprenyltransferase: methoxy-6-polyprenyl- methoxy-6-polyprenyl- cytochrome + III synthase: tRNA--protein map methoxy-6-polyprenyl- lipoyl menA NAD 1,4-benzoquinol 1,4-benzoquinol 3-phospho-D-glycerate dehydrogenase: synthase: synthase/ synthase: DNA map synthetase a stabilizedrecO FPG3_RS00255 transferase: 1,4-benzoquinol synthase: lipA NAD kinase: methylase UbiE: ubiE methylase UbiE: ubiE FPG3_RS10310 FPG3_RS07845 dihydrofolate FPG3_RS08720 mismatch TilS: tilS RecA filament- a [lipoyl-carrier FPG3_RS11340 repair protein methylase UbiE: ubiE FPG3_RS07190 menaquinol-8 menaquinol-9 uroporphyrinogen- 2,3-bisphosphoglycerate- synthase: an N-terminal L- an N-terminal DNA complex 6 demethylmenaquinol-8 3-oxooctanoyl-CoA protein]-N -[(R)- + III synthase: FPG3_RS04965 (6R)-6-pyruvoyl- MutS: mutS menaquinol-6 NADP independent met threonyl-[protein] met L-valyl-[protein] a lysidine 34 dihydrolipoyl]-L-lysine (8S)-8-amino-7- a properly matched FPG3_RS00970 L-phenylalanyl-L- 5,6,7,8- triphosphate Ile2 phosphoglycerate acetyl-CoA C- Phe oxononanoate acyl-carrier protein in tRNA arginyl-[protein] a tRNA tetrahydropterin DNA base pair uroporphyrinogen-III mutase: FPG3_RS06960 acyltransferase: a (6S)-5- FPG3_RS09040 formyltetrahydrofolate Aminoacyl-tRNA Charging tRNA charging 2-phospho-D-glycerate acetyl-CoA C- acyltransferase: an N 6 -L- an [apo BCAA a 1-acyl-2- an N-terminal- FPG3_RS06045 a [protein]- a [protein]-L- a sulfurated 37 a lipid II a peptidoglycan serotonin a RNA-DNA hybrid Phe phosphopyruvate threonylcarbamoyladenine dehydrogenase arachidonoyl- L-glutamine L-methionyl- L-saccharopine methionine phe a tRNA [sulfur carrier] hydratase: eno hexanoyl-CoA in tRNA (3S)-3-methyl-2- E2 protein] N 6 sn-glycerol glycyl-[protein] peptide- oxopentanoate -lipoyl-L-lysine 3-phosphate CTP methionine glu a tRNA glu monofunctional ribonuclease acyl-CoA transglutaminase: type I methionyl saccharopine (S)-S-oxide a tRNA Gln phenylalanine- tRNA (N(6)-L- biosynthetic gln dehydrogenase: FPG3_RS10510 HI: rnhA reductase ser -tRNA ligase asp Ala phosphoenolpyruvate threonylcarbamoyladenosine(37) peptidoglycan phosphatidate aminopeptidase: dehydrogenase: ser a tRNA tRNA asp a tRNA ala FPG3_RS03425 dehydrogenase: ribonuclease HII: elongator subunit cytidylyltransferase: map FPG3_RS11445 MsrA: msrA glutamyl-tRNA met Met met tyr Tyr ile Ile lys Lys arg Arg pro Pro cys Cys thr Thr his His val Val trp Trp asn Asn leu Leu gly Gly -C(2))- methylthiotransferase transglycosylase: FPG3_RS10465 a protein-L- Met initiator tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA tRNA a tRNA a tRNA [+ 3 isozymes] FPG3_RS03380 glutamine-- synthetase: tRNA alpha: pheS MtaB: mtaB mtgA FPG3_RS05245 a [protein] N 6 - methionine- tRNA ligase/ FPG3_RS00060 serine- phenylalanine- aspartate- alanine- pyruvate kinase: pyk (2E)-hexenoyl-CoA [(5-hydroxy-1H- an N-terminal (S)-S-oxide an [apo BCAA dehydrogenase allysine YqeY domain glutamate-- methionine- methionine- -tRNA -tRNA ligase tyrosine-- isoleucine-- -tRNA lysine- arginine-- proline-- cysteine-- threonine- histidine-- -tRNA valine-- tryptophan- asparagine- leucine-- glycine-- a 2-methylsulfanyl-N 6 -L- di-trans,octa-cis a CDP-1-acyl- indol-3-yl)ethyl]- DNA a nucleoside 5'- met glycyl-[protein] glu an unsulfurated a peptidoglycan E2 protein] N 6 -S-[2- fusion protein: tRNA ligase: -tRNA -tRNA ligase: subunit beta: tRNA ligase: tRNA ligase: ligase: -tRNA tRNA ligase: tRNA ligase: tRNA ligase: -tRNA tRNA ligase: ligase: tRNA ligase: -tRNA -tRNA tRNA ligase: tRNA ligase: threonylcarbamoyladenine 37 5'-deoxyadenosine met -undecaprenyl 2-arachidonoyl- L-glutamine monophosphate [sulfur carrier] methylbutanoyl]dihydrolipoyl- FPG3_RS00030 FPG3_RS00055 ligase: metG ligase: metG serS FPG3_RS10530 FPG3_RS00855 FPG3_RS01150 aspS ligase: lysS FPG3_RS04130 FPG3_RS04630 FPG3_RS05210 ligase: thrS FPG3_RS07550 alaS FPG3_RS09175 ligase: trpS ligase: asnS FPG3_RS11395 FPG3_RS11725 pyruvate in tRNA diphosphate glycerol L-lysine Macromolecule Modification (S)-3- an L-methionyl- an L-glutaminyl- an L-glutamyl- an L-methionyl- an L-seryl- an L-phenylalanyl- an L-tyrosyl- an L-isoleucyl- an L-aspartyl- an L-lysyl- an L-arginyl- an L-prolyl- an L-cysteinyl- an L-threonyl- an L-histidyl- an L-alanyl- an L-valyl- an L-tryptophanyl- an L-asparaginyl- an L-leucyl- hydroxyhexanoyl-CoA Gly 6 Gln Glu [elongator Met ser Phe Tyr Ile asp Lys Arg Pro Cys Thr His Ala Val Trp Asn Leu a glycyl-[tRNA ] N -(3-methylbut- all-trans- a [protein] N- a peptidoglycan a peptide with (3R,5S)-3- [tRNA ] [tRNA ] [initiator tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] tRNA-uridine 2-thiolation a [DNA]-3'- + a 5'-phospho- + Met 3-hydroxyacyl-CoA NAD sn-glycerol menadione NADH H tRNA ] a sulfurated [sulfur carrier] 2-en-1-yl)- heptaprenyl terminal-formyl- dimer (S. aureus) L-kynurenine an N-terminal hydroxy-1- and selenation (bacteria) dehydrogenase: hydroxyl [DNA] 1-phosphate adenosine 37 in tRNA diphosphate L-methionine L-methionine pyrroline-5- Fatty Acid and Lipid Biosynthesis FPG3_RS10310 carboxylatepyrroline-5- cys NAD- NADH-quinone penicillin- 3-oxohexanoyl-CoA tRNA (N6-isopentenyl geranylgeranylglyceryl/ peptide binding type I methionyl carboxylate palmitate biosynthesis (type II fatty acid synthase) dependent oxidoreductase: kynureninase: fatty acid elongation -- saturated cysteine adenosine(37)-C2)- heptaprenylglyceryl deformylase: protein aminopeptidase: reductase: acetyl-CoA C- DNA ligase nuoK nuoH nuoF kynU desulfurase: methylthiotransferase phosphate synthase: FPG3_RS08900 2: mrdA map proC acyltransferase: LigA: ligA FPG3_RS10875 FPG3_RS11525 MiaB: miaB FPG3_RS00995 Hyp Cell Structure Biosynthesis an acetoacetyl-[acp] FPG3_RS09040 FPG3_RS10885 peptidoglycan biosynthesis I (meso-diaminopimelate containing) lipid IV biosynthesis (E. coli) an acetoacetyl-[acp] lipid IV biosynthesis (P. putida) A peptidoglycan maturation (meso-diaminopimelate containing) cysteine an N-terminal L- a peptidoglycan A anthranilate acetyl-CoA C- 6 formate ala UDP-N-acetyl-α-D-glucosamine 3-oxoacyl-ACP desulfurase: N -(3-methylbut-2-en- [DNA] NMN 3-heptaprenyl- methionyl-[protein] with D,D cross- D-ala met a peptide a (3R)-3- lipid II (meso acyltransferase: an unsulfurated AMP a (3R)-3- reductase FPG3_RS05750 5'-deoxyadenosine 1-yl)-2-(methylsulfanyl) met sn-glycero- NAD + menadiol link (S. aureus) UDP-N-acetylglucosamine hydroxytetradecanoyl- UDP-N-acetyl- FPG3_RS06045 hydroxydecanoyl- UDP-N-acetyl- diaminopimelate containing) an [L-cysteine adenosine 37 in tRNA [sulfur carrier] 1-phosphate [acp] α FabG: fabG 1-carboxyvinyltransferase: [acp] α-D-glucosamine -D-glucosamine monofunctional desulfurase]-S- murA 3-oxoacyl-[acyl- butanoyl-CoA biosynthetic carrier-protein] a 3-oxoacyl-[acp] sulfanyl-L-cysteine acyl-ACP--UDP-N- acyl-ACP--UDP-N- a mature peptidoglycan (meso di-trans,octa-cis an N-terminal- a dipetide with an N- a [lipoyl-carrier UDP-N-acetyl-α-D-glucosamine-enolpyruvate peptidoglycan acyl-CoA UDP-α-D-glucose O-succinyl-L- an adenosine 37 α-Kdo acetylglucosamine O- reductase: fabG -diaminopimelate containing) -undecaprenyl cys DMAPP CTP L-methionyl-L- protein]-N 6 -[(R) a protein acetylglucosamine O- transglycosylase: dehydrogenase: homoserine in tRNA terminal L-aspartate UDP-N-acetylmuramate acyltransferase: lpxA phosphate alanyl-[protein] -dihydrolipoyl]- acyltransferase: lpxA mtgA a (3R)-3- FPG3_RS03425 dehydrogenase: murB hydroxybutanoyl-[acp] a [TusA sulfur- L-lysine dihydrolipoyl endopeptidase ala UDP-3-O-[(3R)-3- a nascent peptidoglycan 3-oxoacyl-[acyl- [+ 3 isozymes] lytic transglycosylase 3-deoxy-manno- glu UDP-3-O-[(3R)-3- carrier protein]-S- undecaprenyl- cystathionine tRNA (adenosine(37)-N6) type I methionyl dipeptidase dehydrogenase: La: lon UDP-N-acetyl-α-D-muramate hydroxymyristoyl]-N- with (L-alanyl-γ-D-glutamyl- 3-hydroxyacyl- carrier-protein] domain-containing octulosonate hydroxydecanoyl]- sulfanyl-L-cysteine crotonyl-CoA phosphate glucose gamma-synthase: -dimethylallyltransferase aminopeptidase: PepE: pepE lpdA acetyl-α-D-glucosamine meso-2,6-diaminopimeloyl-D- ACP dehydratase: beta-ketoacyl- reductase: fabG protein: FPG3_RS07600 cytidylyltransferase: N-acetyl-α-D- phosphotransferase: FPG3_RS01850 MiaA: miaA map UDP-N-acetylmuramate- bifunctional alanyl-D-alanine) pentapeptide FPG3_RS11025 ACP synthase 3-oxoacyl-ACP endolytic transglycosylase kdsB dihydrolipoyl a peptide glutamate racemase: murI glucosamine FPG3_RS11960 -L-alanine ligase: UDP-3-O-[3- II: fabF reductase MltG: mltG dehydrogenase: bifunctional bifunctional a [TusD sulfur- N 6 -(3-methylbut- a proteinogenic a [lipoyl-carrier FPG3_RS07375 hydroxymyristoyl] N- penicillin-binding penicillin-binding beta-ketoacyl FabG: fabG an N-terminal L- asp lpdA UDP-3-O-[3- UDP-3-O-[3- carrier protein]-S- α succinate 2-en-1-yl)- CMP-Kdo amino acid protein]-N 6 -[(R D-glt acetylglucosamine protein 2: mrdA protein 2: mrdA synthase: (S)-3- a mature peptidoglycan with (L- a mature peptidoglycan strand -D-glucopyranosyl- UMP L-cystathionine met alanyl-[protein] α hydroxymyristoyl] N- hydroxymyristoyl] N- sulfanyl-L-cysteine adenosine 37 )-lipoyl]-L-lysine UDP-N-acetyl- -D-muramoyl-L-alanine deacetylase/3- a mature peptidoglycan with a 2,3,4-saturatedFPG3_RS11215 a (3R)-3-hydroxyacyl-bifunctional hydroxybutanoyl-CoA alanyl-γ-D-glutamyl-meso-2,6- (non-reducing terminus) diphosphoundecaprenol acetylglucosamine a nascent peptidoglycan a nascent peptidoglycan acetylglucosamine in tRNA hydroxyacyl-ACP (L-alanyl-γ-D-glutamyl-meso- fatty acyl-[acp] [acyl-carrier protein]UDP-3-O-[3- 3-hydroxyacyl-CoA deacetylase/3- γ deacetylase/3- diaminopimeloyl-D-alanine) tetrapeptide UDP-N-acetylmuramoyl- with (L-alanyl- -D-glutamyl- with D,D cross-links (meso- 2,6-diaminopimeloyl-D-alanyl- hydroxyacyl-ACP dehydratase: hydroxyacyl-ACP hydroxymyristoyl] N- dehydrogenase: L-alanine--D-glutamate meso-2,6-diaminopimeloyl- diaminopimelate containing) D-alanine) pentapeptide a [TusE sulfur dehydratase: FPG3_RS10220 dehydratase: acetylglucosamine FPG3_RS10310 a [2-oxoglutarate- an N-formyl-L- a 2'- an N-terminal- ligase: FPG3_RS07360 D-alanine) tetrapeptide carrier protein]-S hydrogen a negatively UDP-3-O-(3- deacetylase/3- a uridine 34 in tRNA a sulfurated a (4Z)-hexadec- a tripeptide A(H2) an unfolded FPG3_RS10220 FPG3_RS10220 acetoacetyl-CoA SAM dehydrogenase a malonyl-[acp] methionylaminoacyl- deoxyribonucleoside [DNA] L-methionyl-L- peroxide supercoiled DNA hydroxymyristoyl) hydroxyacyl-ACP -sulfanylcysteine [sulfur carrier] 4-enoyl-[acp] protein meso-diaminopimelate UDP-N-acetyl-α-D-muramoyl- UDP-3-O-(3- LD-carboxypeptidase: E2 protein] N 6 - tRNA 5'-triphosphate seryl-[protein] DNA gyrase/ -α-D-glucosamine a mature peptidoglycan dehydratase: D-ala L-alanyl-D-glutamate hydroxydecanoyl) FPG3_RS00335 a (2E)-but-2-enoyl-[acp] acetyl-CoA C- octanoyl-L-lysine topoisomerase chaperonin UDP-3-O-(3- with D,D cross-links (meso- FPG3_RS10220 tRNA 2- catalase/ -α-D-glucosamine a nascent peptidoglycan acyltransferase: peptidase IV subunit A: hydroxymyristoyl) a nascent peptidoglycan LD-carboxypeptidase: a mature peptidoglycan diaminopimelate containing) thiouridine(34) beta-ketoacyl- peptide DNA polymerase type I methionyl peroxidase GroEL: groL UDP-N-acetylmuramoyl- UDP-3-O-(3- γ γ 3-hydroxyacyl- FPG3_RS06045 lipoyl T: pepT FPG3_RS05440 D-alanine--D-alanine glucosamine N- with L,D cross links (meso- FPG3_RS01775 with (L-alanyl- -D-glutamyl- with (L-alanyl- -D-glutamyl- synthase ACP synthase deformylase: III subunit delta': aminopeptidase: HPI: katG L-alanyl-D-glutamate-- hydroxymyristoyl) ACP dehydratase: synthase: ligase: FPG3_RS05695 acyltransferase: diaminopimelate containing) meso-2,6-diaminopimeloyl- meso-2,6-diaminopimeloyl- MnmA: mnmA acetyl-CoA C- II: fabF FPG3_RS08900 FPG3_RS00105 map type I DNA a protein 2, 6-diaminopimelate glucosamine N- a nascent peptidoglycan with FPG3_RS11025 lipA D-alanine--D-alanine lpxD glycine) tetrapeptide D-alanine) tetrapeptide acyltransferase: [+ 7 isozymes] topoisomerase: ligase: FPG3_RS07350 acyltransferase: (L-alanyl-γ-D-glutamyl-meso- a 2,3,4-saturated enoyl-acyl a trans-2-enoyl- a proteinogenic ligase: FPG3_RS05460 a butanoyl-[acp] a 2-thiouridine 34 FPG3_RS09040 a dipeptide A H O topA [+ 2 isozymes] a [2-oxoglutarate an N-terminal 2 lpxD 2,6-diaminopimelate) tripeptide fatty acyl-[acp] carrier protein [acyl-carrier protein] 5'-deoxyadenosine an unsulfurated a (6Z)-3-oxooctadec- formate a L-methionylaminoacyl- amino acid α UDP-2-N,3-O-bis[(3R)- a mature peptidoglycan in tRNA met dehydrogenase acyl-carrier protein met L-seryl-[protein] a relaxed DNA D-alanyl-D-alanine UDP-N-acetyl- -D-muramoyl-L-alanyl- reductase III: fabG acetyl-CoA [sulfur carrier] 6-enoyl-[acp] tRNA γ [+ 2 isozymes] 3-hydroxytetradecanoyl]- with L,D cross-links (meso- a mature peptidoglycan beta-ketoacyl tRNA uridine-5- E2 protein] N 6 [DNA] -D-glutamyl-meso-2,6-diaminopimelate UDP-2-N-[(3R)-3- α-D-glucosamine diaminopimelate containing) with (L-alanyl-γ-D-glutamyl- synthase: carboxymethylaminomethyl(34) -lipoyl-L-lysine hydroxydodecanoyl]- a mature peptidoglycan with FPG3_RS11215 fatty acid β-oxidation I (generic) bifunctional UDP- UDP-2,3- meso-2,6-diaminopimeloyl- synthesis enzyme MnmG: mnmG 3-O-[(3R)-3- γ (L-alanyl- -D-glutamyl-meso- glycine) tetrapeptide beta-ketoacyl- biotin-carboxyl carrier N-acetylmuramoyl- hydroxydecanoyl]- diacylglucosamine CDP-diacylglycerol tRNA uridine-5- a 2-oxo (R)-methylmalonyl- 2,6-diaminopimelate) tripeptide ACP synthase a (3Z)-alk-3- an (R)-2- tripeptide:D-alanyl-D- α diphosphatase: biosynthesis I protein assembly carboxymethylaminomethyl(34) cob(II)inamide 3-methylbutanoate L-ornithine a uracil in DNA DHAP IPP -D-glucosamine enoyl-CoA ATP halocarboxylate carboxylate CoA alanine ligase/alanine FPG3_RS11435 II: fabF dGTP UDP-2,3- a [biotin carboxyl- synthesis GTPase MnmE: mnmE methylmalonyl- NAD(P)H- isopentenyl- racemase: FPG3_RS10640 nucleoside triphosphate UDP-2,3- DHAP carrier protein]-L-lysine a 5-carboxymethylaminomethyl- CoA mutase: dependent diphosphate diacylglucosamine a 3-oxohexanoyl-[acp] acetate- HAD family uracil-DNA pyrophosphohydrolase: UDP-N-acetylmuramoyl- diacylglucosamine NAD(P)H- 2-thiouridine 34 in tRNA ornithine- FPG3_RS03775 glycerol-3- Delta- diphosphatase: biotin--[acetyl- cob(I)yrinic acid -CoA hydrolase: glycosylase: dependent -oxo-acid mazG methylmalonyl- phosphate tripeptide--D-alanyl- FPG3_RS11435 diphosphatase: 3-oxoacyl-ACP CoA-carboxylase] ligase: acs FPG3_RS10515 isomerase: idi a (2E)-2- a,c-diamide FPG3_RS00315 transaminase: nucleotide D- alanine ligase: FPG3_RS01915 reductase glycerol-3- ligase: CoA dehydrogenase: DMAPP UDP-2,3- enoyl-CoA adenosyltransferase: [+ 2 isozymes] rocD pyrophosphohydrolase: FPG3_RS02435 FabG: fabG phosphate FPG3_RS05225 mutase: scpA FPG3_RS00760 diacylglucosamine lipid X a 5-aminomethyl-2- FPG3_RS05140 3-methylbutanoyl- uracil dehydrogenase: a [biotin carboxyl- an apyrimidinic FPG3_RS01275 succinyl-CoA sn-glycerol α diphosphatase: 3-oxoacyl-[acyl- thiouridine 34 in tRNA CoA diphosphate UDP-N-acetyl- -D-muramoyl-L- lipid-A- FPG3_RS00760 carrier protein]-N a 2,3,4-saturated acyl-CoA a 2,3,4- AMP an (S)-2- a proteinogenic L-glutamate-5- site in DNA dGMP 3-phosphate γ FPG3_RS01915 carrier-protein] sn-glycerol long-chain fatty adenosylcobinamide a halide anion alanyl- -D-glutamyl-meso-2,6- di-trans,octa-cis-undecaprenyl phosphate 6 hydroxycarboxylate disaccharide reductase: fabG -biotinyl-L-lysine fatty acid acid--CoA ligase: dehydrogenase: saturated (3R)-3- triphosphate amino acid semialdehyde diaminopimeloyl-D-alanyl-D-alanine 3-phosphate a 2,3,4- lipid X (P. putida) synthase: lpxB FPG3_RS09065 FPG3_RS08055 hydroxyacyl-CoA a (3R)-3- a 2,3,4-saturated saturated (3S)-3- lipid A disaccharide a 5-methylaminomethyl- [+ 3 isozymes] phospho-N-acetylmuramoyl- lipid-A- hydroxyhexanoyl-[acp] fatty acyl CoA (E. coli) 34 hydroxyacyl-CoA pentapeptide- transferase: a [biotin carboxyl- 2-thiouridine in tRNA β-D-fructofuranose D-sedoheptulose a supercoiled disaccharide a ferrocytochrome an (S)-2- pimeloyl-CoA tetraacyldisaccharide 3-hydroxyacyl- a 1-acyl-sn carrier-protein dimer]- 3-hydroxyacyl-CoA cob(II)alamin stearoyl-CoA ala pro FPG3_RS07355 synthase: lpxB acetyl-CoA C- ATP b halocarboxylate 1-phosphate dATP 1-phosphate duplex DNA 4'-kinase: lpxK ACP dehydratase: -glycerol 3- N 6 -biotinyl-L-lysine dehydrogenase: 5 UvrD-helicase lipid A acyltransferase: pyrroline-5- undecaprenyldiphospho-N-acetylmuramoyl- FPG3_RS11025 phosphate coenzyme A FPG3_RS10310 nucleoside triphosphate domain- disaccharide acetyl-CoA a 5-methylaminomethyl- FPG3_RS06045 class II fructose- carboxylate L-alanyl-γ-D-glutamyl-meso-2,6- lipid IV (E. coli) 1-acyl-sn-glycerol- acetyl-CoA HAD family pyrophosphohydrolase: class II fructose- containing (P. putida) A bifunctional carboxylase 2-(S-geranyl) a 2,3,4-saturated a 2,3,4-saturated acyl-CoA 8-amino-7- bisphosphate reductase: diaminopimeloyl-D-alanyl-D-alanine 3-phosphate carboxylase, acetyl-CoA C- cob(I)yrinic acid hydrolase: mazG bisphosphate protein: UDP-3-O-[3- biotin 34 fatty acyl CoA 3-oxoacyl-CoA desaturase: oxononanoate tetraacyldisaccharide acyltransferase: carboxyltransferase thiouridine in tRNA acyltransferase: a,c-diamide FPG3_RS00315 aldolase: fbaA aldolase: fbaA proC undecaprenyldiphospho- hydroxymyristoyl] N- carboxylase FPG3_RS02100 synthase: nucleotide FPG3_RS00845 (S)-1-pyrroline- 4'-kinase: lpxK FPG3_RS08025 subunit beta: accD FPG3_RS09040 adenosyltransferase: [+ 2 isozymes] muramoylpentapeptide beta-N- acetylglucosamine subunit: accC FPG3_RS07845 pyrophosphohydrolase: [+ 2 isozymes] 5-carboxylate lipid IV FPG3_RS05140 A [+ 2 isozymes] FPG3_RS01275 a single acetylglucosaminyltransferase: deacetylase/3- a [carboxyl-carrier DHAP D-glyceraldehyde DHAP D-erythrose (P. putida) a 1,2-diacyl- a 5-methylaminomethyl- murG hydroxyacyl-ACP protein dimer]-N 6 - a ferricytochrome oleoyl-CoA an (S)-2- dAMP stranded DNA sn-glycerol 2-(Se-phospho) adenosylcobalamin b a halide anion (8S)-8-amino-7- dehydratase: carboxybiotinyl-L-lysine 5 hydroxycarboxylate coenzyme A Nucleoside and Nucleotide Biosynthesis 3-phosphate 34 triphosphate lipid II (meso diaminopimelate containing) selenouridine in tRNA acetyl-CoA oxononanoate FPG3_RS10220 phosphatidate phosphatidylserine and cytidylyltransferase: phosphatidylethanolamine superpathway of pyrimidine guanine and guanosine salvage II a (2E)-hex-2-enoyl-[acp] superpathway of pyrimidine deoxyribonucleoside salvage inosine-5'-phosphate biosynthesis I adenine salvage FPG3_RS05245 biosynthesis I 2503 a 2'- a diphthine- ribonucleotides de novo biosynthesis superpathway of a 5-methylaminomethyl- adenine an (S)-2- UTP D-sedoheptulose superpathway of guanosine 2-methylbutanoate deoxyribonucleoside [translation thr Polyprenyl Biosynthesis adenosine nucleotides a CDP- a CDP-diacylglycerol 34 in 23S rRNA halocarboxylate [DNA] GTP 1,7-bisphosphate nucleotides de novo biosynthesis I 2'-deoxycytidine 2-selenouridine 5'-triphosphate nucleoside triphosphate de novo biosynthesis I AIR diacylglycerol phosphatidylserine elongation threonine gln hydrogencarbonate guanosine in tRNA pyrophosphohydrolase: nucleoside triphosphate 5-(carboxyamino) adenine synthase: factor 2] ammonia- di-trans,poly-cis nucleoside 2'-deoxycytidine 23S rRNA acetate- HAD family mazG pyrophosphohydrolase: class II fructose- diphthine-- IMP imidazole ribonucleotide FPG3_RS03185 DNA -undecaprenyl IMP asp deaminase: kinase: a 3-sn-phosphatidyl- (adenine(2503)-C(2) -CoA hydrolase: nucleotide mazG bisphosphate ammonia ligase: synthase: FPG3_RS02585 a hexanoyl-[acp] polymerase IlvA: ilvA phosphate biosynthesis glutamine- FPG3_RS01495 FPG3_RS01420 L-serine )-methyltransferase ligase: acs FPG3_RS00315 pyrophosphohydrolase: aldolase: fbaA a diphthamide-FPG3_RS10370 N5-CAIR Amino Acid Degradation IV: dinB nucleotide (2E,6E)-farnesyl hydrolyzing IMP adenine deaminase: ade lipoprotein posttranslational RlmN: rlmN FPG3_RS01275 2-oxobutanoate IPP cytidine guanine beta-ketoacyl fatty acid biosynthesis phosphatidylserine [+ 2 isozymes] pyrophosphohydrolase: [translation carbamoyl- dehydrogenase: adenylosuccinate modification (2S)-2- [+ 5 isozymes] diphosphate deaminase: cdd dCMP 5-(carboxyamino)imidazole synthase: initiation (type II) decarboxylase UMP FPG3_RS01275 D-erythrose elongation phosphate guaB synthase: L-leucine degradation I DHAP FPG3_RS11215 family protein: a [prolipoprotein]- L-proline 2503 methylbutanoyl- diphosphate 4-phosphate factor 2] FPG3_RS08190 (d)CMP kinase: ribonucleotide mutase: purE hypoxanthine L-histidine degradation I a 2-methyladenine AMP a (2R)-2- GMP isoprenyl synthase 5'-deoxyadenosine met CoA a halide anion 2'-deoxyuridine FPG3_RS09105 hypoxanthine AMP phosphoribosyltransferase: hpt beta-ketoacyl- acetyl-CoA FPG3_RS05250 L-cysteine degradation I in 23S rRNA hydroxy fatty acid [DNA] small XMP transferase: CAIR ACP synthase acetyl-CoA an L-1- diacylglyceryl subunit: carA dCDP leu FPG3_RS07180 adenylo-succinate thymidine kinase: carboxylase, his hypoxanthine II: fabF phosphatidylethanolamine transferase: branched-chain pro carbamoyl- glutamine- FPG3_RS10635 nucleoside- phosphoribosylaminoimidazolesuccinocarboxamide GMP carboxyltransferase phosphoribosyltransferase: hpt FPG3_RS10540 amino acid histidine proline a mature peptidoglycan a [protein]- (S)-1-pyrroline- di-trans,octa-cis hydrolyzing GMP synthase: FPG3_RS03995 (n) an (R)-2- dTTP phosphate adenylosuccinate deoxynucleoside thymidine diphosphate a 3-oxooctanoyl-[acp] subunit beta: accD prolipoprotein ammonia- DL-allothreonine FAD histidinol -undecaprenyl pyrimidine ribonucleosides salvage I transaminase: dehydrogenase: (meso-DAP containing) halocarboxylate L-threonine nucleoside triphosphate ITP IMP 5-carboxylate synthase synthase: guaA lyase: purB kinase: kinase: malonyl-CoA lyase: hutH SAICAR diacylglyceryl FPG3_RS02300 FPG3_RS09135 L-glutamate histidinol diphosphate large FPG3_RS01420 FPG3_RS04585 IMP 3-oxoacyl-ACP urocanate (S)-1-pyrroline- pyrophosphohydrolase: nucleoside triphosphate metallophosphatase: undecaprenyl- thymidine kinase: cytidine ACP S- transferase: lgt gamma- dehydrogenase: subunit: carB GMP reductase branched-chain 5-carboxylate lytic transglycosylase HAD family FAD:protein FMN mazG pyrophosphohydrolase: FPG3_RS08500 diphosphate AMP FPG3_RS10635 dCTP adenylosuccinate malonyltransferase: a [prolipoprotein]- urocanate serine semialdehyde hisD dUMP FabG: fabG amino acid domain-containing hydrolase: transferase: nucleotide mazG phosphatase: nucleoside uridine fabD S-1,2-diacyl-sn- hydroxymethyltransferase: 5'/3'-nucleotidase dehydrogenase: deoxynucleoside lyase: purB xanthine and aminotransferase: hydratase: protein: FPG3_RS07600 FPG3_RS00315 FPG3_RS04200 pyrophosphohydrolase: carbamoyl guanylate deaminase: kinase: udk 3-oxoacyl-[acyl- glyceryl-L-cysteine nucleotide SurE: surE pruA his FPG3_RS11370 asp kinase: xanthosine salvage FPG3_RS08960 FPG3_RS07900 endolytic transglycosylase FPG3_RS05605 phosphate adenylate kinase: carrier-protein] long-chain fatty 4-methyl-2- [+ 2 isozymes] FPG3_RS01275 pyrophosphohydrolase: di-trans,octa-cis kinase: gmk thymidylate FPG3_RS01420 AICAR FPG3_RS01495 a malonyl-[acp] 4-imidazolone- L-glutamate-5- inosine glu FPG3_RS02600 CMP reductase: fabG acid activation lipoprotein oxopentanoate MltG: mltG a [protein]-FMN- dTMP FPG3_RS01275 -undecaprenyl synthase: cytidine 5-propanoate semialdehyde bifunctional xanthosine signal peptidase: L-threonine phosphate aspartate FPG3_RS01740 deaminase: cdd a (3R)-3- ketoacyl-ACP a long-chain acetaldehyde gly a (2R)-2- AMP IMP GDP phosphoribosylaminoimidazolecarboxamide FPG3_RS01160 imidazolonepropionase: L-glutamate a mature peptidoglycan GlcNAc-1,6-anhMurNAc- a halide anion carbamoyltransferase ADP purine-nucleoside hydroxyoctanoyl-[acp] synthase III: fatty acid (n) hydroxy fatty acid formyltransferase/IMP cyclohydrolase: purH long-chain fatty gamma- (meso-DAP containing) L-Ala-γ-D-Glu-DAP-D-Ala catalytic subunit: phosphorylase: uridine FPG3_RS11475 FPG3_RS08775 3-hydroxyacyl- acid--CoA ligase: an (S-diacyl- a lipoprotein 3-methylbutanoyl- semialdehyde FPG3_RS08700 pyrimidine deoxyribonucleotides FPG3_RS04265 [+ 2 isozymes] ribonucleoside- FAICAR uridine ACP dehydratase: FPG3_RS09065 sn-glyceryl) CoA N-formimino- nucleoside- xanthine signal peptide dehydrogenase: 4 34 a [LuxE]-S- 5-fluorouridine 5'- ribonucleoside- diphosphate de novo biosynthesis I a long-chain a [protein]- an O - a [protein]-S- a uridine CTP diphosphate kinase: udk FPG3_RS11025 -L-cysteinyl- L-glutamate pruA a ferrocytochrome palmitoyl-CoA adenosylcobinamide pyridoxamine diphosphate bifunctional an acetoacetyl-[acp] fatty acyl-CoA signal methylthymine sulfanyl-L-cysteine in tRNA (long-chain fatty monophosphate a protein N-carbamoyl- reductase: UDP CTP [apolipoprotein] b L-cysteine nucleoside triphosphate 5'-phosphate kinase: formimidoylglutamase: 5 bifunctional acyl)-L-cysteine noncanonical reductase: FPG3_RS02340 phosphoribosylaminoimidazolecarboxamide UMP bifunctional peptide in DNA L-aspartate ribonucleoside- glu pyrophosphohydrolase: pyrimidine pyridoxamine FPG3_RS04585 FPG3_RS02340 dTMP formyltransferase/IMP cyclohydrolase: purH UDP-3-O-[3- peptidase 3-methylcrotonyl- FPG3_RS07805 adenosylcobinamide metalloprotease: ribonucleoside- tRNA 2- mazG 5'-phosphate dihydroorotase: diphosphate hydroxymyristoyl] N- SppA: sppA formimidoylglutamase: methylated-DNA-- kinase/ nucleotidase, ribonucleoside- CDP CoA acyl-CoA acyl-CoA FPG3_RS05915 oxidase: pdxH diphosphate reductase: an N-acyl-(S- FPG3_RS09165 L-methionine degradation thiouridine(34) adenosylcobinamide- nucleotide YjjG family: FPG3_RS03920 diphosphate IMP XMP acetylglucosamine methylcrotonoyl- desaturase: [protein]-cysteine S- reductase: reductase FPG3_RS02340 ribonucleoside- purine deoxyribonucleosides salvage diacyl-sn-glyceryl) I (to L-homocysteine) synthase phosphate pyrophosphohydrolase: FPG3_RS02645 dihydroorotase: GTP reductase deacetylase/3- a peptide CoA carboxylase: FPG3_RS02100 methyltransferase: FPG3_RS05400 PLP subunit alpha: dTDP acyl-CoA hydrolysis glu MnmA: mnmA FPG3_RS01275 a peptide FPG3_RS00870 ribonucleoside- diphosphate hydroxyacyl-ACP -L-cysteinyl- FPG3_RS00210 guanylyltransferase: 5-fluorouridine subunit alpha: FPG3_RS02335 FPG3_RS10335 nucleoside- diphosphate reductase: dehydratase: [lipoprotein] met cobU CMP FPG3_RS02335 a 2,3,4-saturated 3-methylglutaconyl- a [LuxE]- a long-chain (S)-dihydroorotate diphosphate reductase FPG3_RS02340 2'-deoxyguanosine 2'-deoxyadenosine FPG3_RS10220 L-serine degradation methionine palmitoleoyl-CoA a ferricytochrome a [protein]- a 2-thiouridine 34 adenosyl-cobinamide fatty acyl CoA CoA a thymine in DNA a [protein]-S- L-cysteine fatty aldehyde dADP kinase: subunit alpha: deoxynucleoside deoxynucleoside acyl-CoA adenosyltransferase: b L-cysteine in tRNA phosphate ribonucleoside- 5 methyl-L-cysteine quinone- FPG3_RS04585 FPG3_RS02335 adenine and adenosine salvage III kinase: kinase: a (2E)-oct-2-enoyl-[acp] thioesterase: FPG3_RS01445 dGDP diphosphate ser dependent nucleoside- dUDP FPG3_RS01420 FPG3_RS01420 FPG3_RS07725 queuosine SAM dTTP reductase dihydroorotate diphosphate dGMP dAMP biosynthesis I (de novo) L-serine UDP-N-acetyl- decaprenyl-diphospho-N- an O 6 - 3 subunit alpha: [+ 5 isozymes] a [protein]- D-xylulose D-erythrose an N -methyladenine a [release factor]- a double nucleoside- nucleoside- a 2,3,4-saturated ammonia-lyase: α aci-nitroethane roseoflavin a DNA segment dehydrogenase: kinase: adenine HMG-CoA -D-glucosamine acetylmuramoyl-pentapeptide methylguanine 5-phosphate 4-phosphate in DNA L-glutamine stranded DNA diphosphate diphosphate FPG3_RS02335 fatty acid L-cysteine FPG3_RS08550 FPG3_RS04585 purine-nucleoside preQ 2-aminoprop-FPG3_RS06290 in DNA peptide chain DNA gyrase/ bifunctional kinase: kinase: 0 hydroxymethylglutaryl- PRPP dCDP phosphorylase: 2-enoate undecaprenyldiphospho- release factor topoisomerase riboflavin kinase/ recombinase orotate FPG3_RS04585 FPG3_RS04585 an octanoyl-[acp] CoA lyase: transketolase: DNA-3- 2-nitropropane FAD synthetase: RecA: recA dATP nucleoside- FPG3_RS04265 SAH muramoylpentapeptide beta-N- methylated-DNA-- N(5)-glutamine IV subunit A: FPG3_RS08555 FPG3_RS05610 methyladenine dioxygenase: FPG3_RS01230 dUTP diphosphate adenosine preQ acetylglucosaminyltransferase: [protein]-cysteine S- methyltransferase: FPG3_RS05440 a DNA segment orotate dGTP superpathway of 5-aminoimidazole beta-ketoacyl 1 transketolase: glycosylase I: FPG3_RS08860 roseoflavin kinase: dGDP dADP acetoacetate murG methyltransferase: prmC [+ 2 isozymes] in reverse phosphoribosyltransferase: dUTP synthase: adenosylhomocysteinase: FPG3_RS11350 5 ribonucleotide biosynthesis tRNA FPG3_RS00210 FPG3_RS05615 a [release factor]-N a negatively 5'-phosphate orientation FPG3_RS05515 diphosphatase: FPG3_RS04585 adenosine FPG3_RS11215 2-iminopropanoate FPG3_RS01005 nucleoside- nucleoside- guanosine(34) -methyl-L-glutamine supercoiled DNA dut deaminase: L-threonine decaprenyl-pyrophosphoryl- UDP acetaldehyde nitrite PRPP dCTP diphosphate diphosphate beta-ketoacyl- transglycosylase D-glyceraldehyde an apurinic site FPG3_RS11805 degradation II (N-acetylglucosamine)-N- a [protein]-S- orotidine 5'- amidophosphoribosyltransferase: [+ 2 isozymes] ACP synthase L-homocysteine a guanine in DNA F6P 3-methyladenine kinase: kinase: Tgt: tgt acetylmuramyl-(pentapeptide) methyl-L-cysteine 3-phosphate within DNA phosphate a 7-aminomethyl-7- CMP FPG3_RS01040 dUMP inosine FPG3_RS04585 FPG3_RS04585 II: fabF β 34 superpathway of pyrimidine 5-phospho- - deazaguanosine thr pyruvate orotidine-5'- nucleobases salvage phosphorylation D-ribosylamine thymidylate a 3-oxodecanoyl-[acp] in tRNA L-threonine 3- 10 34 a thiocarboxylated RNase III mRNA 2-deoxy-D-ribose 2251 purine-nucleoside dGTP dATP an L-methionyl- an N - a uridine guanosine a [protein]- phosphate CMP synthase: dehydrogenase: [SAMP] C- processing chorismate a reduced c- CAIR uracil phosphoribosylamine- tRNA preQ1(34) S- [initiator tRNA Met ] formyltetrahydrofolate in tRNA 5-phosphate in 23S rRNA L-histidine decarboxylase: (d)CMP kinase: FPG3_RS01740 phosphorylase: 3-oxoacyl-ACP FPG3_RS01015 L-glutamine type cytochrome phosphoribosyltransferase: -glycine ligase: purD adenosylmethionine terminal glycine substrate bifunctional 3-deoxy-7- 23S rRNA histidine kinase: 5-(carboxyamino) pyrF FPG3_RS09105 FPG3_RS04265 guanine and guanosine salvage reductase L-2-amino-3- L-asparagine cytochrome- dTMP ribosyltransferase- degradation I phosphoheptulonate (guanosine(2251) FPG3_RS09235 imidazole FPG3_RS04410 CDP FabG: fabG oxobutanoate degradation I deoxyribose- c peroxidase: UMP GAR isomerase QueA: queA methionyl-tRNA tRNA 2- synthase/chorismate -2'-O)- ribonucleotide [+ 2 isozymes] hypoxanthine ribonuclease phosphate FPG3_RS05120 [+ 3 isozymes] nucleoside- 3-oxoacyl-[acyl- 34 glycine C- gln thiouridine(34) mutase type II: methyltransferase a [protein]- mutase: purE UMP kinase: UMP an epoxyqueuosine formyltransferase: III: rnc aldolase: phosphoribosylglycinamide guanosine carrier-protein] acetyltransferase: kbl imidazole asn synthase FPG3_RS01315 RlmB: rlmB an oxidized c- N-phospho- FPG3_RS02225 diphosphate in tRNA FPG3_RS07630 2-O- AIR UMP kinase: formyltransferase 2: purT dTDP purine-nucleoside reductase: fabG asparaginase: deoC type cytochrome kinase: hypoxanthine glycerol MnmA: mnmA prephenate 2251 L-histidine UDP FPG3_RS02225 phosphorylase: tRNA FPG3_RS11190 methylguanosine FPG3_RS04585 nucleoside- phosphoribosyltransferase: hpt gly phosphate RNase III FGAR FPG3_RS04265 a (3R)-3- epoxyqueuosine(34) an N-formyl- in 23S rRNA UDP synthase: asparaginase: 34 an mRNA fragment processing D-glyceraldehyde nucleoside- CTP diphosphate hydroxydecanoyl-[acp] reductase QueG: queG L-methionyl- a tetrahydrofolate a [SAMP] C- a 2-thiouridine acetaldehyde guanine L-alanine FPG3_RS03830 product mRNA 3-phosphate diphosphate kinase: 34 hisF hisH met terminal glycine in tRNA nucleoside-diphosphate phosphoribosylformylglycinamidine IMP 3-hydroxyacyl- a queuosine degradation IV asp [initiator tRNA ] kinase: FPG3_RS04585 [+ 6 isozymes] kinase: FPG3_RS04585 synthase: purL ACP dehydratase: in tRNA FPG3_RS04585 dTTP hypoxanthine glu a [glycine-cleavage gln UTP FPG3_RS11025 a [protein]- a DNA methyl a [protein]-L- 4-(2'- FGAM phosphoribosyltransferase: hpt ala H O [DNA] DNA with lesion arsenate a sulfurated [sulfur carrier] SAM complex H protein] a tRNA precursor diphosphate 2 carboxyphenyl)- UTP CTP synthase: bifunctional alanine L-cysteine phosphotriester β-isoaspartate N 6 -octanoyl-L-lysine DNA polymerase protein-L- 4-oxobutyryl-CoA excinuclease arsenate FPG3_RS08205 phosphoribosylformylglycinamidine UDP-3-O-[3- dehydrogenase: 1,4-dihydroxy- CTP synthase: GMP tRNA processing III subunit epsilon: isoaspartate(D- ABC subunit reductase CTP cyclo-ligase: FPG3_RS05625 hydroxymyristoyl] N- FPG3_RS10660 methylated-DNA-- 2-naphthoyl- FPG3_RS08205 inorganic FPG3_RS10055 aspartate) O- UvrB: uvrB (glutaredoxin) acetylglucosamine [protein]-cysteine S- ribonuclease Z: CoA synthase: [+ 2 isozymes] lipoyl diphosphatase: [+ 2 isozymes] methyltransferase: [+ 3 isozymes] : arsC AIR deacetylase/3- a polycistronic pyruvate FPG3_RS09140 a 2'- FPG3_RS04685 CTP synthase: lipA methyltransferase: FPG3_RS01770 FPG3_RS08155 1,4-dihydroxy-2- DNA without hydroxyacyl-ACP tRNA precursor deoxyribonucleoside a protein L-β- arsenite FPG3_RS00210 naphthoyl-CoA lesion dehydratase: 5'-monophosphate isoaspartate a [glycine-cleavage a single-stranded α FPG3_RS10220 an unsulfurated + -methyl ester 5'-deoxyadenosine complex H protein] N 6 a [protein]-S- mature tRNA phosphate H met [DNA] oligoribonucleotide -[(R)-lipoyl]-L-lysine [sulfur carrier] methyl-L-cysteine Carbohydrate Biosynthesis a (2E)-dec-2-enoyl-[acp] a tRNA precursor a tRNA precursor Inorganic Nutrient Metabolism with a 5' with a 5'

gluconeogenesis I extension and extension and a urea cycle GDP-α-D- trans,octacis a 2,3,4-saturated a 2'- 1402 (3R)-3- β D-glyceraldehyde D-sedoheptulose a cytidine a double-stranded dTDP- -L-rhamnose thiosulfate oxidation III (multienzyme complex) -decaprenyl an oligopeptide hydroxybutanoyl- glycogen biosynthesis I (from ADP-D-Glucose) a long 3' trailer short 3' extension mannose 3-phosphate 7-phosphate 1,2-diacyl-sn- deoxyribonucleoside [DNA] in 16S rRNA oligonucleotide ser biosynthesis Amino Acid Biosynthesis ribonuclease phosphate CTP bifunctional CoA (S)-malate ammonium glycerol 3-phosphate 5'-triphosphate 16S rRNA α P protein oligopeptidase B: enoyl-CoA L-serine -D-glucopyranose D-glucopyranose a decanoyl-[acyl-carrier protein] a [SoxY protein]-L-cysteine (cytidine(1402)-2'-O) oligoribonuclease/ 1-phosphate L-histidine biosynthesis component: polyprenol transketolase: -methyltransferase: PAP phosphatase FPG3_RS06220 hydratase: ammonia-lyase: 6-phosphate L-lysine biosynthesis I L-tryptophan biosynthesis L-homocysteine biosynthesis glutamine- phosphatidate RNA-directed glucose-1-phosphate L-homoserine a tRNA rnpA monophosphomannose FPG3_RS05610 rsmI NrnA: FPG3_RS00290 FPG3_RS06290 phospho- beta-ketoacyl hydrolyzing cytidylyltransferase: DNA polymerase: a 2'-O- thymidylyltransferase: biosynthesis precursor with a tRNA precursor synthase: FPG3_RS00875 transketolase: FPG3_RS08235 a peptide malate sugar mutase: PRPP synthase: arg carbamoyl- FPG3_RS05245 FPG3_RS06885 methylcytidine 1402 crotonyl-CoA pyruvate FPG3_RS03710 a 5' extension with a short FPG3_RS05615 a nucleoside 5'- dehydrogenase: FPG3_RS03685 asp gln L-homoserine FPG3_RS11215 phosphate a [SoxY protein]-S- in 16S rRNA glucose-1-phosphate ATP chorismate asp 3' extension trans,octacis- monophosphate FPG3_RS04900 α-D- aspartate kinase: beta-ketoacyl- synthase sulfosulfanyl-L-cysteine thymidylyltransferase phosphoribosyltransferase: aspartate kinase: homoserine O- ribonuclease decaprenylphospho- GDP a CDP-2,3,4-saturated- FPG3_RS01345 small β D-ribose 5- D-xylulose [DNA] malate glucopyranose ACP synthase P protein -D-mannose diacylglycerol RfbA: rfbA FPG3_RS10140 anthranilate FPG3_RS01345 acetyltransferase: subunit: carA cytochrome c: phosphate 5-phosphate dTDP-α-D-glucose 1-phosphate aspartate kinase: II: fabF dehydrogenase: synthase: aspartate kinase: FPG3_RS01350 component: β FPG3_RS01590 carbamoyl- FPG3_RS09195 FPG3_RS07025 1-(5-phospho- -D-ribosyl)-ATP FPG3_RS04825 rnpA oxaloacetate dTDP-glucose 4,6- L-aspartyl-4-phosphate FPG3_RS01590 O-acetyl-L- a 3-oxododecanoyl-[acp] [+ 3 isozymes] L-aspartyl- phosphate a [pyruvate dehydrogenase E2 an [eIF5A- a single- a cytidine 1402 527 L-homocysteine D-ribose 5- dehydratase: rfbB homoserine hydrogen sulfide L-arginino- phenylacetate spermidine a guanine a (1->4)- bifunctional 4-phosphate L-ornithine synthase a [SoxY protein]-S- a [SoxY protein]-S a sulfurated [sulfur carrier] SAM 6 stranded RNA thr phosphate pyruvate dTDP-4-dehydro-6- α 3-oxoacyl-ACP an uncharged succinate protein] N -octanoyl-L-lysine precursor]-lysine in 16S rRNA in 16S rRNA thiolactone phosphoenolpyruvate α-D-glucan ADP- -D-glucose phosphoribosyl- aspartate- anthranilate PRPP large disulfanyl-L-cysteine -sulfanyl-L-cysteine 16S rRNA 16S rRNA ribose 5- deoxy-α-D-glucopyranose aspartate- reductase tRNA aminopeptidase: L-threonine 3- carboxykinase glycogen/starch AMP cyclohydrolase/ semialdehyde O-acetylhomoserine subunit: carB (cytosine(1402)-N(4) (guanine(527)-N(7) phosphate dTDP-4- semialdehyde FabG: fabG deoxyhypusine polyribonucleotide FPG3_RS11425 dehydrogenase: (ATP): pckA synthase: phosphoribosyl-ATP dehydrogenase: aminocarboxypropyltransferase/ phenylacetate--CoA )-methyltransferase )-methyltransferase isomerase dehydrorhamnose anthranilate dehydrogenase: 3-oxoacyl-[acyl- carbamoyl synthase: nucleotidyltransferase: FPG3_RS01015 FPG3_RS00595 diphosphatase HisIE: FPG3_RS04880 cysteine synthase: FPG3_RS01355 lipoyl synthase: lipA ligase: FPG3_RS10995 4 RsmH: rsmH 7 RsmG: rsmG B: rpiB phosphoribosyltransferase: trpD phosphate FPG3_RS09120 FPG3_RS07425 an N - an N - D-ribulose 3,5-epimerase: rfbC FPG3_RS10105 FPG3_RS04880 carrier-protein] ornithine L-homocysteine a (1->4)- L-aspartate 4- methylcytidine 1402 methylguanine 527 aminoacetone phosphoenolpyruvate dTDP-4-dehydro- reductase: fabG 6 37 carbamoyltransferase: 5-phosphate α-D-glucan semialdehyde L-aspartate 4- N -L-threonylcarbamoyladenosine β-L-rhamnose 1-(5-phospho-β-D-ribosyl)-AMP FPG3_RS08700 a [SoxY protein]-S-(2- an [eIF5A- in 16S rRNA in 16S rRNA N-(5-phosphoribosyl)-anthranilate semialdehyde L-homocysteine -modified tRNA biosynthesis propane- a single- phosphopyruvate a (3R)-3- L-citrulline sulfodisulfanyl)-L-cysteine a [pyruvate dehydrogenase phenylacetyl-CoA diphosphate a nucleoside dTDP-4- 4-hydroxy- 5'-deoxyadenosine AMP 1,3-diamine precursor]- stranded RNA hydratase: eno bifunctional homoserine L-glutamine hydroxydodecanoyl-[acp] met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] diphosphate dehydrorhamnose tetrahydrodipicolinate L-isoleucine phosphoribosylanthranilate deoxyhypusine phosphoribosyl- dehydrogenase: biosynthesis I ATP reductase: rfbD a glycogen synthase: biosynthesis I isomerase: FPG3_RS04805 3-hydroxyacyl- thr 2-phospho-D-glycerate AMP cyclohydrolase/ FPG3_RS08485 FPG3_RS01345 ACP dehydratase: polyphosphate metabolism dTDP-β-L-rhamnose UDP-α-D- phosphoribosyl-ATP (from threonine) 1-(2-carboxyphenylamino)-1- glycine biosynthesis II (2S,4S)-4- glu FPG3_RS11025 sulfur a ribonucleoside adenine 1618 a guanine 966 (R)-10- D-ribulose 2,3-bisphosphoglycerate- galactose deoxy-D-ribulose 5-phosphate L-homoserine a 5-L-glutamyl- isobutanoate lipid IV (E. coli) CMP-Kdo a single 15-cis-phytoene diphosphatase HisIE: hydroxy-2,3,4,5- thr glutamine threonylcarbamoyl- an amino acid A Hydroxystearate 5-phosphate independent a [glycine-cleavage bifunctional long chain reduction II (via [peptide] triphosphate stranded DNA in 23S rRNA in 16S rRNA biosynthesis FPG3_RS10105 indole-3-glycerol 6 23S rRNA ribulose- tetrahydrodipicolinate threonine complex H protein] N - synthetase: AMP synthase: polyphosphate polysulfide) 16S rRNA oleate hydratase: phytoene phosphoglycerate α 1-(5-phospho-β-D-ribosyl)- phosphate UDP-3-O-[3- UDP- -D-glucose 4-hydroxy- ammonia- aminomethyldihydrolipoyl- FPG3_RS04985 FPG3_RS09445 (adenine(1618)-N(6) (guanine(966)-N(2) FPG3_RS10305 phosphate 3- desaturase: mutase: hydroxymyristoyl] N- 0 3-deoxy-D-manno- UDP-glucose 5-[(5-phosphoribosylamino) tetrahydrodipicolinate synthase TrpC: trpC gln S acetate--CoA DNA )-methyltransferase )-methyltransferase oleate hydratase: epimerase: FPG3_RS06960 (2Z)-2-aminobut-lyase IlvA: ilvA L-lysine acetylglucosamine threonylcarbamoyl- gamma- octulosonic acid crtI 4-epimerase methylideneamino]imidazole- reductase: dapB polyphosphate ligase: acs primase: 6 RlmF: rlmF 2 RsmD: rsmD FPG3_RS07410 (1S,2R)-1-C-(indol-3- aminomethyl- deacetylase/3- AMP synthase: transferase: an N - an N - FPG3_RS10315 9,15,9'-tri-cis 4-carboxamide 2-enoate glycine cleavage system exopolyphosphatase: glutamyltransferase: ggt dnaG D-xylulose 3-phospho-D-glycerate GalE: galE (S)-2,3,4,5- yl)glycerol 3-phosphate transferring gly FPG3_RS06215 kinase: FPG3_RS02060 methyladenine 1618 methylguanine 966 oleate -ζ-carotene UDP-α-D-galactose aminomethyltransferase hydroxyacyl-ACP FPG3_RS02235 5-phosphate 1-(5-phosphoribosyl)-5- tetrahydrodipicolinate glycine FPG3_RS05055 a polysulfide tryptophan synthase: GcvT: gcvT dehydratase: [+ 2 isozymes] in 23S rRNA in 16S rRNA phosphoglycerate [(5- phosphoribosylamino) [+ 2 isozymes] an α-(5-L- isobutanoyl-CoA 2,3,4,5- dehydrogenase: FPG3_RS10220 (L-threonylcarbamoyl) polysulfide diphosphate α-Kdo-(2->6)- ssDNA/pppN(pN) kinase: methylideneamino]imidazole-4- FPG3_RS04795 trpB [+ 2 isozymes] glutamyl)- AMP CMP tetrahydropyridine- gcvP adenylate a peptide hybrid 2-iminobutanoate reductase lipid IV (E. coli) n -1 FPG3_RS00140 carboxamide isomerase: hisA ser a [glycine-cleavage a [glycine-cleavage amino acid A 2,6-dicarboxylate N- indole [+ 2 isozymes] a (2E)-dodec-2-enoyl-[acp] NrfD: nrfD 6 6 tRNA (adenosine(37)-N6)- long chain UDP-N-acetyl-D- phosphoribulosylformimino- succinyltransferase: complex H protein] N complex H protein] N 13-DPG threonylcarbamoyltransferase polyphosphate glucosamine biosynthesis I AICAR-phosphate FPG3_RS09520 -dihydrolipoyl-L-lysine -[(R)-lipoyl]-L-lysine a polysulfide complex ATPase subunit UDP-N-acetyl-α-D-muramoyl-L- a DNA containing a [protein]- a guanine 46 a [protein]-L- GDP-α-D- nicotinate adenine tryptophan synthase: NAD + H O a [protein]-L-lysine a holo [PedD acyl- γ 2 type I D-glucopyranose N-succinyl-2-amino- type 1 TsaE: tsaE alanyl- -D-glutamyl-meso-2,6- glu an apurinic/ L-glutamine in tRNA proline (ω = 180) mannose dinucleotide imidazole glycerol FPG3_RS04795 trpB carrier protein] GDP- glyceraldehyde- 6-phosphate 6-ketopimelate 2-oxobutanoate [+ 2 isozymes] diaminopimeloyl-D-alanyl-D-alanine apyrimidinic site tRNA peptidylprolyl NAD(+) glucose-6- phosphate ACP S- mannose 4,6- a dodecanoyl-[acp] an N 6 -L- (guanosine(46)-N7) isomerase: synthase: 3-phosphate phosphate biosynthetic- aminomethyl- malonyltransferase: synthase: hisF hisH 37 transglutaminase: -methyltransferase FPG3_RS08160 dehydratase: dehydrogenase: isomerase: pgi trp threonylcarbamoyladenine amino acid nadE type transferring penicillin-binding endonuclease III: FPG3_RS10510 fabD TrmB: trmB [+ 5 isozymes] gmd triose-phosphate gap F6P in tRNA dehydrogenase: a malonyl- an N 7 - GDP-4-dehydro- N-succinyl-L,L-2,6- acetolactate glycine L-cysteine biosynthesis I protein 2: mrdA FPG3_RS03885 a [protein]-L- NAD + D-erythro-1-(imidazol-4- L-arginine beta-ketoacyl FPG3_RS08070 46 α isomerase: [+ 2 isozymes] AICAR synthase: dehydrogenase: [PedD acyl- methylguanine proline (ω = 0) -D-rhamnose glutamine-- yl)-glycerol 3-phosphate diaminopimelate degradation I synthase: FPG3_RS04475 D-glyceraldehyde ilvN ilvB gcvP a protein with an carrier protein] in tRNA (arginase pathway) FPG3_RS11215 Carboxylate Degradation UDP-N-acetylmuramoyl-L- 6 DHAP 3-phosphate fructose-6- bifunctional histidinol- ser a 3'-terminal a 5'-phospho- N -(γ-glutamyl)- (S)-2-aceto-2- [+ 4 isozymes] laurate N-end rule pathway I (prokaryotic) alanyl-γ-D-glutamyl-meso-2,6- 2-oxoglutarate ammonium NADH H + phosphate phosphatase/ serine acetyltransferase: beta-ketoacyl- D-ala unsaturated sugar [DNA] L-lysine crosslink hydroxybutanoate arg diaminopimeloyl-D-alanine transaminase imidazoleglycerol- L-valine biosynthesis FPG3_RS03115 ACP synthase long-chain fatty leucyl/ glutaryl-CoA (isomerizing) L,L-diaminopimelate ketol-acid pyruvate decarboxylation to acetyl CoA I phosphate serine acetyltransferase: II: fabF acid--CoA ligase: phenylalanyl- degradation class II fructose- : glmS reductoisomerase: dehydratase pyruvate FPG3_RS03140 FPG3_RS09065 tRNA--protein pyruvate α undecaprenyl-diphospho-N lysine within a guanine 37 bisphosphate diaminopimelate ilvC UDP-N-acetyl- -D-glucosamine a [DNA]-3'- a nucleoside a holo [PedN acyl- a uridine in tRNA (S)-NADPHX MeOH D-glucosamine HisB: hisB biosynthetic- L-ornithine O-acetyl-L-serine transferase: glutaryl-CoA a [pyruvate dehydrogenase -acetylmuramoyl-L-alanyl-γ- an octanoyl-[acp] 6 dehydrogenase gcv protein H hydroxyl triphosphate in tRNA aldolase: fbaA epimerase: (R)-2,3-dihydroxy- a 3-oxotetradecanoyl-[acp] lauroyl-CoA E2 protein] N -lipoyl-L-lysine carrier protein] 6-phosphate type FPG3_RS11340 a [protein] acyl-CoA complex E1 D-glutamyl-L-lysyl- D-alanine nucleotide tRNA tRNA 3-(imidazol-4-yl)-2- FPG3_RS03305 superpathway of L- an N-terminal NAD(P)H-hydrate catalase/ 3-methylpentanoate acetolactate ornithine- O-acetylhomoserine N-terminal L- dehydrogenase: pyruvate pyrophosphohydrolase: ACP S- (guanosine(37)-N1) dihydrouridine phosphoglucosamine oxopropyl phosphate asparagine biosynthesis arginyl-[protein] component undecaprenyldiphospho- dehydratase: peroxidase dihydroxy-acid -oxo-acid 3-oxoacyl-ACP leucyl-L-arginine FPG3_RS01815 lipoyl(octanoyl) malonyltransferase: -methyltransferase mutase: glmM meso-diaminopimelate synthase: aminocarboxypropyltransferase/ (E)-glutaconyl- subunit beta: muramoylpentapeptide beta-N- exodeoxyribonuclease FPG3_RS01275 synthase FPG3_RS06080 HPI: katG β-D-fructose 1,6- dehydratase: transaminase: reductase transferase fabD α histidinol-phosphate ilvN ilvB cysteine synthase: FPG3_RS01355 CoA FPG3_RS01760 acetylglucosaminyltransferase: III: xth nucleoside triphosphate 1 TrmD: trmD DusB: dusB -D-glucosamine rocD asp FabG: fabG a malonyl[PedN an N - a 5,6-dihydrouridine NADPH formaldehyde bisphosphate transaminase: hisC ilvD leucyl/ LipB: lipB 37 1-phosphate (S)-2-acetolactate acyl-CoA murG pyrophosphohydrolase: acyl-carrier methylguanine cys 3-oxoacyl-[acyl- stearate biosynthesis dihydrolipoyl pyruvate in tRNA class 1 fructose- (3S)-3-methyl-2- L-glutamate-5- phenylalanyl- dehydrogenase: a 2'- mazG protein] in tRNA ketol-acid carrier-protein] II (bacteria and plants) dehydrogenase: dehydrogenase a [glycine-cleavage a [DNA]-3'- bisphosphatase: fbp L-histidinol phosphate oxopentanoate semialdehyde asparagine tRNA--protein ditrans,octacis-undecaprenyldiphospho- UDP deoxyribonucleoside a nucleoside 5'- reductoisomerase: asparagine FPG3_RS01815 lpdA (acetyl- acyl-carrier protein complex H protein] hydroxyl PRPP biosynthesis branched-chain synthase reductase: fabG transferase: N-acetyl-(N-acetylglucosaminyl)muramoyl- monophosphate lys ilvC L-glutamate synthase L-glutamate transferring) N 6 -octanoyl-L-lysine 5'-monophosphate F6P N-acetyl-α-D- histidinol- a palmitoyl-[acp] FPG3_RS11340 a [protein] crotonyl-CoA dihydrolipoyl L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine amino acid (2R)-2,3- gamma- B: asnB (glutamine- biosynthesis III a (3R)-3- an N-terminal E1 component glucosamine D-ribose 5- phosphatase: beta-ketoacyl N-terminal L- dehydrogenase: transaminase: dihydroxy-3- semialdehyde asparagine hydrolyzing) hydroxytetradecanoyl-[acp] L-lysyl-[protein] subunit glucose-6- 1-phosphate phosphate FPG3_RS03010 synthase: leucyl-L-lysine a [pyruvate dehydrogenaselpdA pyruvate a [pyruvate dehydrogenase ribose-phosphate FPG3_RS02300 dehydrogenase: : asnB L-alanine 2-oxoglutarate α undecaprenyl-diphospho-N-acetylmuramoyl-L- UDP-N-acetyl- a 3,5,7,9,11,13,15- 37 phosphate methylbutanoate synthase 3-hydroxyacyl- E2 protein] N 6 - dehydrogenasealpha: pdhAE2 protein] N 6 -S- UDP-N-acetyl- -D-glucosamine O-succinyl-L- RNase R degradation guanine naringenin bifunctional histidinol- biosynthesis III NADP-specific FPG3_RS11215 γ methanethiol α-D-glucosamine ethanol pyrophosphokinase: branched-chain dihydroxy-acid pruA (glutamine- ACP dehydratase: alanyl- -D-glutamyl-L-lysyl- D-alanyl-D-alanine substrate RNA hepta-oxo- Phe an L-amino acid chalcone isomerase: pgi asparagine (S)-3- dihydrolipoyl-L-lysine complex acetyldihydrolipoyl-L-lysine homoserine in tRNA FPG3_RS00790 phosphatase/ amino acid dehydratase: hydrolyzing) glutamate FPG3_RS11025 beta-ketoacyl- hexadecanoyl-[PKS-acp] tRNA chalcone catalase/ D-glucopyranose UDP-N-acetyl- alanine racemization synthase hydroxybutanoyl- dihydrolipoamide undecaprenyldiphospho- aldo/keto amino acid PRPP imidazoleglycerol- glu cys dehydrogenase: ACP synthase (guanosine(37)-N1) 6-phosphate α aminotransferase: ilvD : asnB B: asnB acetyltransferase: muramoylpentapeptide beta-N- UDP-N- isomerase: peroxidase -D-glucosamine phosphate gdhA bifunctional II: fabF CoA cystathionine ribonuclease reductase: -methyltransferase dehydrogenase: FPG3_RS08960 3-methyl-2- cysteine a 3-oxooctadecanoyl- FPG3_RS02465 acetylglucosaminyltransferase: acetylglucosamine FPG3_RS08065 HPI: katG dehydratase UDP-3-O-[3- 3-hydroxyacyl-CoA gamma-synthase: R: rnr FPG3_RS00345 TrmD: trmD FPG3_RS08070 ala oxobutanoate desulfurase: glu [acp] mevalonate degradation murG 2-epimerase 9-hydroxy-3,5,7,11,13,15- an N 1 - HisB: hisB hydroxymyristoyl] N- dehydrogenase: FPG3_RS01850 a 2-oxo (2S)-naringenin acetaldehyde bifunctional UDP- ile asn asn FPG3_RS11525 (hydrolyzing): neuC hexaoxohexadecanoyl- methylguanine 37 branched-chain acetylglucosamine 3-oxoacyl- FPG3_RS10310 carboxylate N-acetylmuramoyl- Phe histidinol amino acid cysteine deacetylase/3- [PKS-acp] in tRNA tripeptide:D-alanyl- ACP (R)-mevalonate ditrans,octacis-undecaprenyldiphospho-N- UDP a diribonucleotide a nucleoside 5'- transaminase: desulfurase: hydroxyacyl-ACP acetoacetyl-CoA succinate N-acetyl-α-D- UDP D-alanine ligase/ reductase acetyl-CoA acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- met monophosphate histidinol FPG3_RS02300 FPG3_RS05750 dehydratase: hydroxymethylglutaryl-CoA mannosamine alanine racemase: FabG: fabG acetyl-CoA C- alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine dehydrogenase: hisD ala FPG3_RS10220 reductase, degradative: FPG3_RS10640 branched-chain glycine biosynthesis I 3-oxoacyl- acyltransferase: FPG3_RS11285 D-ala amino acid [acyl-carrier- FPG3_RS06045 histidinal a [procollagen]- a long-chain a cytidine 34 phosphoenol aminotransferase: a (2E)-tetradec-2-enoyl-[acp] dethiobiotin a sulfurated 2-oxoglutarate coenzyme A NADPH H + a holo [BryP acyl- a folate nitric oxide protein] acetyl-CoA C- HMG-CoA SAM L-proline fatty acyl-CoA ser acetate [sulfur carrier] carrier protein] in tRNA pyruvate histidinol FPG3_RS08960 reductase: acyltransferase: tRNA (cytidine(34) serine conversion dihydrofolate NO-inducible dehydrogenase: hisD fabG FPG3_RS09040 ACP S- -2'-O)- pyruvate hydroxymethyltransferase: to acetyl-CoA hydroxymethylglutaryl-CoA proline acyl-CoA reductase: flavohemoprotein: val a (3R)-3- biotin CoA pyrophosphatase: malonyltransferase: methyltransferase: kinase: pyk FPG3_RS05605 lyase: FPG3_RS08555 hydroxylase: reductase: FPG3_RS01725 hmpA hydroxyoctadecanoyl- acetyl-CoA acetate synthase FPG3_RS08020 fabD FPG3_RS07705 his gly FPG3_RS00430 FPG3_RS05400 a malonyl- a 2'-O- a myristoyl-[acp] [acp] acetate- BioB: bioB a 7,8-dihydrofolate nitrate pyruvate methylcytidine 34 3-hydroxyacyl- -CoA [BryP acyl- acetoacetate acetyl-CoA in tRNA beta-ketoacyl ACP dehydratase: ligase: acs a [procollagen] carrier protein] an unsulfurated 4'-phosphopantetheine a long-chain synthase: FPG3_RS11025 acetyl-CoA biotin 5'-deoxyadenosine met trans 4-hyroxy- succinate 3',5'-ADP [sulfur carrier] fatty aldehyde FPG3_RS11215 bifunctional L-proline beta-ketoacyl- UDP-3-O-[3- Nucleoside and Nucleotide Degradation ACP synthase hydroxymyristoyl] N- 4-fumaryl- a uracil 1498 (R)-methylmalonyl- uridine glutathione + a holo [BryU acyl- II: fabF acetylglucosamine hydrogen selenide O-acetyl-L-serine hypoglycin A H hydrogencarbonate prephenate purine nucleotides degradation II (aerobic) acetoacetate carrier protein] in 16S rRNA CoA deacetylase/3- 16S rRNA methylmalonyl- prephenate uridine a 3-oxohexadecanoyl-[acp] hydroxyacyl-ACP ACP S- (uracil(1498)-N(3))- kinase: udk carbonate CoA dehydratase: dehydratase: O-acetylhomoserine fumarylacetoacetase: malonyltransferase: methyltransferase: AMP dehydratase: epimerase: mce FPG3_RS01325 3-oxoacyl-ACP FPG3_RS10220 aminocarboxypropyltransferase/ gamma- fahA fabD FPG3_RS09575 UMP can a malonyl- an N 3 - (S)-methylmalonyl- 3-phenyl-2- reductase cysteine synthase: FPG3_RS01355 glutamyltransferase: ggt FabG: fabG a (2E)-octadec- metallophosphatase: [BryU acyl- methyluracil 1498 CoA oxopropanoate 2-enoyl-[acp] FPG3_RS08500 carrier protein] in 16S rRNA 3-oxoacyl-[acyl- fumarate 5'/3'-nucleotidase acetate CO H O acetoacetate carrier-protein] (2E)-octadec- IMP L-selenocysteine hypoglycin B L-cysteinylglycine 2 2 reductase: fabG 2-enoyl-[acp] SurE: surE GMP a (3R)-3- reductase: IMP fabG adenosine dehydrogenase: hydroxyhexadecanoyl-[acp] 1518 cytidine metallophosphatase: guaB methanethiol O-acetyl-L- a lipid II F6P adenine / a ribonucleoside acetoacetyl-CoA citrate (S)-NADHX 3-hydroxyacyl- a stearoyl-[acp] adenosine FPG3_RS08500 homoserine adenine 1519 in 16S rRNA 5'-monophosphate 16S rRNA 3-hydroxybutyryl- uridine ACP dehydratase: deaminase: 5'/3'-nucleotidase 5'/3'-nucleotidase aconitate NAD(P)H-hydrate XMP (adenine(1518)-N(6)/ CoA kinase: udk FPG3_RS11025 FPG3_RS11805 SurE: surE fructose-6- SurE: surE hydratase: dehydratase: O-acetylhomoserine penicillin-binding adenine(1519)-N(6))- dehydrogenase: phosphate metallophosphatase: FPG3_RS03555 FPG3_RS06080 bifunctional metallophosphatase: aminocarboxypropyltransferase/ protein 2: mrdA dimethyltransferase FPG3_RS08145 CMP inosine guanosine aldolase: fsa FPG3_RS08500 (S)-3- UDP-3-O-[3- FPG3_RS08500 cysteine synthase: FPG3_RS01355 RsmA: rsmA D-threo-isocitrate NADH stearate 6 1518 a ribonucleoside hydroxybutanoyl- hydroxymyristoyl] N- 5'/3'-nucleotidase N -dimethyladenine a N-acetylglucosamine--N- 6 1519 CoA acetylglucosamine purine-nucleoside purine-nucleoside SurE: surE D-glyceraldehyde /N -dimethyladenine long-chain fatty D-ala acetylmuramyl-(tetrapeptide) dihydroxyacetone deacetylase/3- phosphorylase: phosphorylase: acetate met in 16S rRNA acid--CoA ligase: pyrophosphoryl-undecaprenol 3-phosphate hydroxyacyl-ACP FPG3_RS04265 FPG3_RS04265 FPG3_RS09065 xanthosine dehydratase: FPG3_RS10220 stearoyl-CoA hypoxanthine guanine 7,8-dihydrofolate + D-threo-7,8- (R)-mevalonate an insertion sequence (2S)- purine-nucleoside a proteinogenic leukotriene-C4 NADPH H 1-aminocyclopropane- glutaryl-CoA monoglutamate dihydroneopterin diphosphate element IS30 ethylmalonyl-CoA a (2E)-hexadec-2-enoyl-[acp] phosphorylase: amino acid 1-carboxylate 1-aminocyclopropane- transposase: methylmalonyl- acyl-CoA FPG3_RS04265 dihydrofolate 1-carboxylate diphosphomevalonate FPG3_RS07990 CoA dehydrogenase: dihydroneopterin reductase: deaminase/D-cysteine decarboxylase: mvaD [+ 3 isozymes] epimerase: mce FPG3_RS01815 gamma- aldolase: folB an insertion xanthine FPG3_RS01725 desulfhydrase: (2R)- glutamyltransferase: ggt sequence IS30 with crotonyl-CoA FPG3_RS03350 IPP ethylmalonyl-CoA a palmitoyl-[acp] purine ribonucleosides degradation integrated transposon 2-oxobutanoate 5,6,7,8- 6-(hydroxymethyl) glycolaldehyde an α-(γ-L-glutamyl) NADP + leukotriene-D4 -7,8-dihydropterin -L-amino acid tetrahydrofolate urate adenosine

palmitate adenosine DNA combined with (1R,6R)-6-hydroxy-2- a 2'- pinocembrin a proteinogenic glutathione glycyl-glycine glutathione bleomycin B deaminase: exogenous DNA to form D-cysteine succinylcyclohexa-2,4- 2 amino acid deoxyribonucleoside chalcone long-chain fatty FPG3_RS11805 a recombinational junction diene-1-carboxylate deoxynucleoside Holliday junction 1-aminocyclopropane-1- o-succinylbenzoate chalcone acid--CoA ligase: kinase: aminopeptidase: resolvase RuvX: ruvX carboxylate deaminase/D- synthase: isomerase: FPG3_RS09065 xanthosine adenosine inosine guanosine gamma- FPG3_RS01420 FPG3_RS08065 FPG3_RS11425 gamma- crossover junction cysteine desulfhydrase: FPG3_RS04755 glutamyltransferase: ggt a 2'- deamido- palmitoyl-CoA glutamyltransferase: ggt endodeoxyribonuclease FPG3_RS03350 (2S)-pinocembrin 2-succinylbenzoate deoxyribonucleoside bleomycin B resolution of recombinationalRuvC: ruvC pyruvate 2 purine-nucleoside purine-nucleoside 5'-monophosphate purine-nucleoside purine-nucleoside γ-L-glutamyl- junction formation phosphorylase: phosphorylase: phosphorylase: phosphorylase: α γ L-cysteinylglycine an -( -L-glutamyl) L-cysteinylglycine glycylglycine of two intact strands FPG3_RS04265 FPG3_RS04265 FPG3_RS04265 FPG3_RS04265 -L-amino acid

α-D-ribose- a [histone]-N 6 - a glucosylated a pseudouridine 1915 3-(4- D-arabinofuranose 1-phosphate NAD + UDP-α-D-glucose a cytosine in DNA isoliquiritigenin bleomycin A acetyl-L-lysine glycogenin in 23S rRNA hydroxyphenyl) 5-phosphate 2 pyrimidine deoxyribonucleotides UTP and CTP dephosphorylation I 23S rRNA pyruvate 3-deoxy-8- DNA (cytosine-5-)- chalcone dephosphorylation aminopeptidase: glycogen/starch (pseudouridine(1915)- 4-hydroxyphenylpyruvate phosphooctulonate methyltransferase: isomerase: NAD-dependent FPG3_RS11425 nucleoside triphosphate D-ribose 5- UTP N(3))-methyltransferase dioxygenase: hppD synthase: kdsA dcm deacylase: synthase: FPG3_RS08065 pyrophosphohydrolase: phosphate 3 RlmH: rlmH [+ 2 isozymes] FPG3_RS08650 FPG3_RS00595 an N - deamido- mazG CTP synthase: KDO-8P a 5-methylcytosine (2S)-liquiritigenin methylpseudouridine 1915 homogentisate bleomycin A nucleotide FPG3_RS08205 in DNA 2 a glucosylated in 23S rRNA pyrophosphohydrolase: 2''-O-acetyl- UDP UDP a [histone]-L-lysine nicotinamide glycogenin FPG3_RS01275 CTP ADP-ribose dCTP dCMP

6 6 an N -L- 34 2604 1939 UMP + a [protein]-N - a 5-carboxymethylaminomethyluridine a uridine a uracil dUTP diphosphatase: dut NAD 37 uroporphyrinogen-I homogentisate (S)-malate CDP acetyl-L-lysine threonylcarbamoyladenine in tRNA Leu in 23S rRNA in 23S rRNA [+ 2 isozymes] metallophosphatase: in tRNA dUTP dUMP tRNA (cytidine(34) 23S rRNA 23S rRNA homogentisate malate:quinone tRNA uroporphyrinogen FPG3_RS08500 -2'-O)- pseudouridine(2604) (uracil(1939)-C(5)) 1,2-dioxygenase: oxidoreductase: NAD-dependent threonylcarbamoyladenosine decarboxylase: hemE 5'/3'-nucleotidase methyltransferase: synthase RluF: rluF -methyltransferase FPG3_RS01190 FPG3_RS08905 CMP deacylase: dehydratase: FPG3_RS08940 5-hydroxy-CTP 5-hydroxy-CMP SurE: surE a cyclic N 6 -L- FPG3_RS07705 a pseudouridine 2604 RlmD: rlmD 4-maleyl- FPG3_RS08650 a 5-carboxymethylaminomethyl- coproporphyrinogen I a 5-methyluracil 1939 oxaloacetate metallophosphatase: threonylcarbamoyladenosine in 23S rRNA acetoacetate uridine 2'-O-methyluridine 34 in tRNA Leu in 23S rRNA 37 in tRNA FPG3_RS08500 2''-O-acetyl- 5'/3'-nucleotidase ADP-ribose nicotinamide a [protein]-L-lysine SurE: surE cytidine 3-methyl-2- 5,10-methylene- 2-amino-6-[1-hydroxyethyl]- O-phospho- NMN NaMN oxaloacetate ferroheme o a bleomycin oxobutanoate tetrahydromethanopterin 7-methyl-7,8-dihydropterin L-serine 2-amino-4-hydroxy-6- 3-phosphoserine/ metallophosphatase: metallophosphatase: citrate synthase: heme A synthase: aminopeptidase: purine deoxyribonucleosides degradation I 3-methyl-2-oxobutanoate hydroxymethyldihydropteridine phosphohydroxythreonine FPG3_RS08500 FPG3_RS08500 FPG3_RS02855 FPG3_RS09435 FPG3_RS11425 diphosphokinase: folK hydroxymethyltransferase: transaminase: serC panB [1-(2-amino-7-methyl-4-oxo- 1-(β-D ribofuranosyl) β-D- 1,2-dihydroxypropane- a deamido- adenosine deaminase: 7,8-dihydro-3H-pteridin- nicotinamide ferroheme a 2'-deoxyadenosine 3-phosphooxypyruvate ribosylnicotinate 1,2,3-tricarboxylate bleomycin FPG3_RS11805 6-yl)]ethyl diphosphate

2'-deoxyinosine 2'-deoxyguanosine 2-dehydropantoate THMPT

purine-nucleoside 2,5-diamino-6-(5- 55 purine-nucleoside phosphorylase: purine-nucleoside 38-40 3-phenyl-2- dTDP-4-amino-4,6- a uridine 2'-deoxycytidine phospho-D-ribitylamino) a uridine in tRNA (R)-mevalonate a chalcone phosphorylase: FPG3_RS04265 phosphorylase: oxopropanoate dideoxy-α-D-galactose in tRNA deoxynucleoside FPG3_RS04265 pyrimidin-4(3H)-one RluA family pseudouridine dTDP-4-amino-4,6- tRNA mevalonate chalcone FPG3_RS04265 bifunctional 4-hydroxyphenylpyruvate kinase: synthase: FPG3_RS05450 dideoxygalactose pseudouridine(55) kinase: isomerase: diaminohydroxyphosphoribosylaminopyrimidine dioxygenase: hppD FPG3_RS01420 deaminase/5-amino-6-(5-phosphoribosylamino) tRNA pseudouridine(38- transaminase: rffA synthase TruB: truB FPG3_RS01650 FPG3_RS08065 2-deoxy-α-D-ribose 1-phosphate dTDP-4-dehydro-6- dCMP uracil reductase RibD: ribD 40) synthase TruA: truA (2-hydroxyphenyl) a pseudouridine 55 (R)-5- 5-amino-6-(5-phospho- 38-40 deoxy-α-D-glucopyranose a flavanone a pseudouridine in tRNA acetate in tRNA phosphomevalonate D-ribitylamino)uracil

reactive oxygen species degradation Detoxification arsenate arginine detoxification dependent superoxide II (glutaredoxin) acid resistance arsenate superoxide arg dismutase: arsenate arsenate decarboxylase: FPG3_RS00850 reductase detoxification V FPG3_RS09125 superoxide (glutaredoxin) agmatine dismutase: : arsC arsenate FPG3_RS05260 [+ 2 isozymes] glyceraldehyde- arsenite hydrogen 3-phosphate peroxide dehydrogenase: 1-arseno-3-FPG3_RS03295 catalase/ phosphoglycerate peroxidase arsenite HPI: katG H O hydroxyl radical 2 O 1-arseno-3- 2 phosphoglycerate a reduced plastocyanin a reduced an oxidized plastocyanin O plastocyanin 2 an inorganic an oxidized a nicotinamide an amino an amino an amino a nucleoside H O anion plastocyanin mononucleotide acid acid acid 2 a lipopolysaccharide a lipopolysaccharide

cytochrome- RS09110 RS07505 RS03195 RS11740 c oxidase, RS01975 RS00990 RS09005 RS01185 RS07010 RS01975 cbb3-type

an inorganic a nicotinamide a nucleoside an amino an amino an amino a reduced anion a lipopolysaccharide a lipopolysaccharide O mononucleotide acid acid acid 2 c-type O 2 H O 2 cytochrome H O 2 an oxidized c-type cytochrome This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.