Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000299235Cyc: Leptospirillum ferriphilum ML-04 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

phosphate

phosphate phosphate phosphate ammonium ammonium ammonium predicted ABC transporter RS12230 RS11960 RS10935 RS01775 RS01785 RS04585 of phosphate

phosphate phosphate phosphate ammonium ammonium ammonium phosphate

Macromolecule Modification Inorganic Nutrient Metabolism tRNA-uridine 2-thiolation UDP-N-acetyl- undecaprenyl- a carboxy- a nascent a peptidoglycan an [amino-group β 34 a nucleoside cob(II)yrinate a,c- , Carrier, and Vitamin Biosynthesis selenate reduction α-D-glucosamine diphospho-N- adenylated- peptidoglycan a uracil in DNA D-glycero- -D- a cytidine lys dimer (meso- met carrier protein]- [2Fe-2S] iron-sulfur thioredoxin flavin biosynthesis I (bacteria and plants) lipoate biosynthesis lipoate salvage I benzimidazolyl adenosylcobamide lipoate biosynthesis pyridoxal 5'-phosphate biosynthesis I folate transformations III (E. coli) Fatty Acid and Lipid Biosynthesis and selenation (bacteria) cys ATP triphosphate RNA diamide biosynthesis I acetylmuramoyl- [ThiS sulfur- (meso-DAP manno-heptose in tRNA Ile2 diaminopimelate C-terminal-γ- cluster biosynthesis pathway and incorporation I biosynthesis from and incorporation II amino-acid N- (early cobalt insertion) L-alanyl-γ-D- carrier protein] containing) 1-phosphate containing) (L-glutamate 5- adenosylcobinamide-GDP D-erythrose a tetrahydrofolate palmitate biosynthesis cys selenate uracil-DNA acetyltransferase: uroporphyrinogen-III an oxidized (R)-lipoate 4-phosphate gondoate biosynthesis sulfate glutamyl-L-lysyl- tRNA(Ile)-lysidine DNA- LFML04_RS10300 semialdehyde-2-N-acetyl- L-cysteine desulfurase GTP an octanoyl-[acp] lipoate-- benzimidazole octanoate (type II fatty acid synthase) glycosylase: uroporphyrinogen-III thioredoxin octanoyl-[acyl-carrier (anaerobic) adenylyltransferase: sat D-alanyl-D-alanine D-glycero-beta-D- synthetase: penicillin- directed RNA yl)-L-glutamategamma- protein : nicotinate-nucleotide-- lipoate-- cysteine desulfurase: UDP-N- IscS subfamily lytic transglycosylase LFML04_RS00725 bifunctional C-: cysteine desulfurase: protein] biosynthesis adenosine 5'- manno-heptose LFML04_RS02125 binding glutamyl- bifunctional LFML04_RS01050 dimethylbenzimidazole protein ligase: an acetoacetyl-[acp] LFML04_RS03125 acetylglucosamine- cysteine desulfurase: domain-containing uracil-DNA glutamate N- cobA LFML04_RS03125 a [lipoyl-carrier [(R)- (mitochondria, yeast) a malonyl-[acp] an oleoyl-[acp] phosphoselenate 1-phosphate protein subunit phosphate 3,4-dihydroxy- phosphoribosyltransferase: a [lipoyl-carrier LFML04_RS01050protein] 4-phospho- IscS subfamily -N-acetylmuramyl- LFML04_RS02340 protein: glycosylase: tRNA acetyltransferase/ an [amino-group precorrin-1 thioredoxin- protein] N 6 - lipoyl]adenylate adenylyltransferase: 2: mrdA omega: rpoZ reductase: IscS subfamily 6 3-oxoacyl-[acyl- cysteine desulfurase: (pentapeptide) cysteine desulfurase: LFML04_RS04415 lysidine(34) amino-acid carrier protein]- 2-butanone- octanoyl-L-lysine cobT N -octanoyl-L-lysine D-erythronate an acetoacetyl-[acp] LFML04_RS05165 rfaE2 argC uroporphyrinogen-III cysteine desulfurase: disulfide lipoate-- benzimidazole carrier-protein] 3-oxoacyl-[acyl- LFML04_RS02340 sulfite oxidation II pyrophosphoryl- LFML04_RS03125 endolytic synthetase [+ 2 isozymes] acetyltransferase C-terminal-γ- 4-phosphate lipoyl lipoyl beta-ketoacyl- C-methyltransferase: LFML04_RS02340 reductase: protein ligase: ribotide phosphate reductase: fabG carrier-protein] an [L-cysteine undecaprenol N- transglycosylase TilS: tilS a peptidoglycan ArgJ: argJ (5-phospho- synthase/GTP synthase: ACP synthase β trxB LFML04_RS01050 synthase: lipA desulfurase]-S- selenite acetylglucosamine MltG: mltG an apyrimidinic uracil ADP-D-glycero- - with D,D cross- D-ala N-acetyl-L- L-glutamyl)- cobA an S-sulfanyl-[L- cyclohydrolase II: lipA cobalamin 5 serine a (3R)-3- reductase: fabG II: fabF sulfite a thiocarboxylated- a [lipoyl-carrier superpathway of thiamine diphosphate biosynthesis II a [lipoyl-carrier (3R)-3-hydroxy-2-oxo- a (3R)-3- sulfanyl-L-cysteine : site in DNA D-manno-heptose links (meso- RNA methionine L-glutamate cysteine desulfurase] LFML04_RS06305 a [lipoyl-carrier phosphate 6 a 7,8-dihydrofolate hydroxymethyltransferase:a 5-methyltetrahydrofolate hydroxybutanoyl-[acp] adenylyl-sulfate ala [ThiS sulfur- 34 precorrin-2 protein]-N 6 -[(R protein]-N -[(R)- 4 phosphooxybutanoate hydroxybutanoyl-[acp] LFML04_RS12585 AMP a lysidine 2,5-diamino-6- 6 reductase Ile2 diaminopimelate sulfite RS09035 sulfite scaffold protein]-N -[(R) synthase CobS: dihydrolipoyl]-L-lysine LFML04_RS11350 3-hydroxyacyl- ditrans,octacis- UDP carrier protein] a mature a nascent in tRNA a reduced (5-phospho-D- )-lipoyl]-L-lysine D-glyceraldehyde aminomethyltransferase 3-hydroxyacyl- an (11Z)-3-oxo- subunit alpha: containing) bifunctional precorrin- protein for -dihydrolipoyl]- cys LFML04_RS05805 pyruvate ACP undecaprenyldiphospho- peptidoglycan peptidoglycan thioredoxin ribosylamino) Coα-[α-(benzimidazolyl) 3-phosphate GcvT: gcvT ACP dehydratase icos-11-enoyl-[acp] LFML04_RS02365 β 2 dehydrogenase/ iron-sulfur L-lysine a [ThiS sulfur- FabZ: fabZ a [TusA sulfur- selenodiglutathione N-acetyl-(N-acetyl- -D- with (L-alanyl- (meso-DAP pyrimidin- ]-Coβ-adenosylcobamide a (6S)-5-formyltetrahydrofolate FabZ: fabZ 3-oxoacyl-[acyl- APS sirohydrochlorin cluster cysteine desulfurase: carrier protein] 4-phosphooxy- glycine cleavage system bifunctional carrier protein]-S- glucosaminyl)muramoyl- γ-D-glutamyl- containing) with sulfate RS11860 sulfate 4(3H)-one 5'-phosphate 1-deoxy-D- γ ferrochelatase: LFML04_RS03125 protein GcvH: gcvH a (2E)-but-2-enoyl-[acp] carrier-protein] sulfanyl-L-cysteine L-alanyl- -D-glutamyl-L- meso-2,6- GlcNAc terminus assembly: iscU bifunctional L-threonine xylulose-5- methylenetetrahydrofolate5-formyltetrahydrofolate a (2E)-but-2-enoyl-[acp] LFML04_RS12350 an S-sulfanyl-[cysteine reductase: fabG lysyl-D-alanyl-D-alanine diaminopimeloyl- diaminohydroxyphosphoribosylaminopyrimidine IscS subfamily 4-hydroxythreonine- phosphate dehydrogenase/ cyclo-ligase: desulfurase]-[disordered- cysteine desulfurase: methenyltetrahydrofolateLFML04_RS07080 enoyl-ACP enoyl-ACP a (3R,11Z)-3-hydroxy- D-alanine) a reduced sirohydrochlorin deaminase/5-amino-6-(5-phosphoribosylamino) 4-phosphate synthase: glutathioselenol form scaffold LFML04_RS02340 a carboxy- Coα-[α-(benzimidazolyl) cyclohydrolase FolD: folD reductase: reductase: icos-11-enoyl-[acp] a [TusD sulfur- tetrapeptide H O c-type uracil reductase RibD: ribD dehydrogenase dxs sulfate 2 an [L-cysteine adenylated- β a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate LFML04_RS05190 protein] complex 5-amino-6-(5- ]-Co -adenosylcobamide PdxA: pdxA LFML04_RS05190 3-hydroxyacyl- carrier protein]-S- RS08985 cytochrome [cysteine desulfurase]-S- desulfurase]-S- [ThiS sulfur- sulfanyl-L-cysteine an oxidized phospho-D- 3-amino-1- 1-deoxy-D- bifunctional ACP dehydratase a mature peptidoglycan a [bis(guanylyl L-alanyl-γ-D- a peptidoglycan (E)-4-hydroxy-3- O c-type sulfanylcysteine:[acceptor sulfanyl-L-cysteine carrier protein] a butanoyl-[acp] a butanoyl-[acp] [EntB aryl- 2 ribosylamino)uracil hydroxyacetone coenzyme A H O sec D-ribulose D-glyceraldehyde xylulose 5- methylenetetrahydrofolate FabZ: fabZ (meso-diaminopimelate molybdopterin) cys glutamyl-meso-2,6- 2 ile dimer (E. faeciums) methylbut-2-en- ser a tRNA cytochromea reduced cobalt- protein]-cysteine bifunctional hypoxanthine carrier protein] GTP 5-phosphate 3-phosphate 1-phosphate phosphate dehydrogenase/ beta-ketoacyl- hydrogen selenide containing) PRPP cofactor diaminopimeloyl- 1-yl diphosphate H O c-type sirohydrochlorin sulfurtransferase: diaminohydroxyphosphoribosylaminopyrimidine superpathway of coenzyme A biosynthesis I (bacteria) cysteine desulfurase: beta-ketoacyl- a (2E,11Z)-icosa- branched chain flavodoxin- 2 bifunctional methenyltetrahydrofolate ACP synthase a [TusE sulfur chaperone]- D-alanine RS09540 cytochrome LFML04_RS02340 deaminase/5-amino-6-(5-phosphoribosylamino) LFML04_RS03125 1-deoxy-D- pyridoxine 5'- bis(guanylyl molybdopterin) ACP synthase 2,11-dienoyl-[acp] amino acid penicillin- dependent an oxidized a [cysteine desulfurase]- gly 34 carrier protein]-S L-cysteine holo-[acyl- 3,4-dihydroxy- 3-methyl-2- a 5,10- IscS subfamily xylulose-5- cofactor sulfurylation cyclohydrolase FolD: folD II: fabF II: fabF a uridine in tRNA lytic transglycosylase GTPase aminotransferase: binding (E)-4-hydroxy- serine- O c-type S-sulfanyl-[disordered- uracil reductase RibD: ribD phosphate synthase: enoyl-ACP -sulfanylcysteine carrier- 2 2-butanone- 5-amino-6-(5- oxobutanoate methylenetetrahydrofolate cysteine desulfurase: phosphate superpathway of tetrahydrofolate biosynthesis domain-containing hypoxanthine HflX: hflX LFML04_RS02085 protein 3-methylbut- -tRNA acytochrome reduced form scaffold LFML04_RS05150 an N 10 -formyltetrahydrofolate reductase: protein] LD-carboxypeptidase: 4-phosphate synthase: glycine a 3-oxohexanoyl-[acp] a 3-oxohexanoyl-[acp] protein: phosphoribosyltransferase: hpt IscS subfamily 2: mrdA 2-enyl- ligase: H O c-type cobalt-factor III protein] complex phospho-D- LFML04_RS02340 cys LFML04_RS05190 tRNA 2- thiosulfate oxidation III (multienzyme complex) synthase: LFML04_RS10535 [+ 4 isozymes] branched-chain 2 synthase/GTP 3-methyl-2-oxobutanoate dxs oxidase LFML04_RS04415 cysteine desulfurase: diphosphate serS RS06455 cytochrome cysteine desulfurase: ribitylamino)uracil pyridoxine 3-oxoacyl-[acyl- thiouridine(34) acpS amino acid an oxidized cyclohydrolase II: hydroxymethyltransferase: a thiocarboxylated- 1-deoxy-D- ThiO: thiO 3-oxoacyl-[acyl- LFML04_RS02340 synthase: ispG LFML04_RS03125 GTP cysteine desulfurase: a gondoyl-[acp] endolytic + transaminase: a peptidoglycan 2-C-methyl-D- O c-type 5'-phosphate carrier-protein] carrier-protein] synthase a [SoxY protein]-L-cysteine γ H 2 LFML04_RS06305 panB [ThiS sulfur- xylulose 5- LFML04_RS03125 transglycosylase L-alanyl- -D- phosphate tetramer with a D-ala erythritol-2,4- a reduced IscS subfamily 2-iminoacetate reductase: fabG reductase: fabG MnmA: mnmA cysteine desulfurase: GDP LFML04_RS00635 an L-seryl- cytochrome 1-deoxy-L- asp carrier protein] phosphate MltG: mltG IMP a holo-[EntB aryl- D-ala glutamyl-meso- (3S)-3-methyl-2- D,D cross-link cyclodiphosphate H O c-type cysteine desulfurase: GTP IscS subfamily lipoate salvage II LFML04_RS03125 3',5'-ADP sec 2 glycero-tetrulose a (3R)-3- a (3R)-3- carrier protein] diaminopimelate oxopentanoate [tRNA ] cytochrome cobalt-precorrin-3 LFML04_RS02340 ARP adenosylcobalamin 2-dehydropantoate cyclohydrolase cysteine desulfurase: 34 (Enterococcus RS09530 an oxidized an S-sulfanyl-[cysteine 4-phosphate aspartate 1- thiazole synthase: hydroxyhexanoyl-[acp] hydroxyhexanoyl-[acp] a 2-thiouridine salvage from cobalamin I FolE: folE LFML04_RS02340 a [lipoyl-carrier in tRNA a mature peptidoglycan a mature peptidoglycan a [bis(guanylyl faecium) O c-type cobalt-precorrin 3 desulfurase]-S- decarboxylase: LFML04_RS00480 7,8- PLP an [L-cysteine 6 a [SoxY protein]-S- 2 AIR protein]-N -[(R 3-hydroxyacyl- 3-hydroxyacyl- with (L-alanyl-γ-D- strand (non- ala molybdopterin) H + RS05585 cytochromeH + methyltransferase: sulfanyl-[disordered- 6,7-dimethyl-8- LFML04_RS10070 desulfurase]-S- tRNA uridine-5- sulfosulfanyl-L-cysteine cob(I)alamin 2-[(2R,5Z)- dihydroneopterin )-lipoyl]-L-lysine ACP dehydratase ACP dehydratase phosphatidylserine and glutamyl-meso-2,6- reducing terminus) cofactor cobJ form scaffold ribityllumazine 3'-triphosphate sulfanyl-L-cysteine carboxymethylaminomethyl(34) β phosphomethylpyrimidine 2-carboxy-4- FabZ: fabZ FabZ: fabZ phosphatidylethanolamine diaminopimeloyl-D- chaperone]-S- protein] complex synthase: -alanine (R)-pantoate cysteine desulfurase: synthesis MnmG: mnmG cytochrome c: cobalt-precorrin-4 [cysteine desulfurase]-S- LFML04_RS06310 synthase ThiC: thiC methylthiazol-5(2H bis(guanylyl (R)-lipoate biosynthesis I LFML04_RS04920 alanine) tetrapeptide sulfanyl-L-cysteine LFML04_RS03125 a (2E)-hex-2-enoyl-[acp] a (2E)-hex-2-enoyl-[acp] tRNA uridine-5- H + RS09825 H + sulfanylcysteine:[acceptor cob(II)alamin )-ylidene]ethyl molybdopterin) IscS subfamily a CDP-diacylglycerol carboxymethylaminomethyl(34) [+ 2 isozymes] cobalt precorrin- protein]-cysteine pantoate--beta- HMP-P phosphate 7,8- cofactor lipoate-- 11 6,7-dimethyl-8-(1- enoyl-ACP CDP-diacylglycerol--serine synthesis GTPase MnmE: mnmE a ring-opened 7- a peptidoglycan a 1-acyl-2- an N-terminal- a [2-oxoglutarate a peptide with 4 (C )- cob(I)yrinic acid thiamine diphosphate salvage II cysteine desulfurase: protein ligase: enoyl-ACP a [SoxY protein]-S- a [SoxY protein]-S + [EntF L-seryl- sulfurtransferase: D-ribityl)lumazine alanine ligase: thiazole dihydroneopterin methylguanine menadione NADH H dimer (generic) coenzyme A arachidonoyl- L-methionyl-L- dehydrogenase an N-terminal a protein methyltransferase: a,c-diamide hydroxymethylpyrimidine/ LFML04_RS02340 LFML04_RS01050 reductase: reductase: O-phosphatidyltransferase: a 5-carboxymethylaminomethyl- disulfanyl-L-cysteine -sulfanyl-L-cysteine carrier protein] ATP roseoflavin LFML04_RS02340 LFML04_RS01430 tautomerase: 3'-phosphate 6 F0F1 ATP a [cysteine phosphomethylpyrimidine a [bis(guanylyl LFML04_RS05190 pssA 34 in DNA phosphatidylcholine threonyl-[protein] E2 protein] N L-methionine + + cobM : adenosyltransferase: 4-amino-2-methyl-5- [(R)- LFML04_RS05190 2-thiouridine in tRNA 5'-phosphate ATP- H H desulfurase]-(S- : LFML04_RS00495 LFML04_RS00485 molybdopterin) a 3-sn-phosphatidyl-L-serine -dihydrolipoyl- synthase cobalt- LFML04_RS07255 cobO 2-(2-carboxy-4- pyrimidinemethanol [bis-MGD lipoyl]adenylate NADH-quinone lytic transglycosylase dihydrolipoyl dependent sulfanyl) -[disordered- cofactor a hexanoyl-[acp] a hexanoyl-[acp] holo-[acyl- type I methionyl L-lysine type I methionyl 2 cob(II)alamin- (R)-pantothenate methylthiazol-5- hydroxymethylpyrimidine/ cofactor bifunctional DNA- : domain-containing phospholipase D: protease precorrin-5A form scaffold HMP-PP lipoate-- phosphatidylserine carrier- dehydrogenase: bifunctional riboflavin [corrinoid yl)ethyl phosphate D-erythro-7,8- phosphomethylpyrimidine chaperone]-S- chaperone]- formamidopyrimidine LFML04_RS04515 protein: LFML04_RS01810 aminopeptidase: aminopeptidase: subunit cobalt-precorrin protein] complex type III pantothenate protein ligase: beta-ketoacyl- beta-ketoacyl- decarboxylase family a 5-aminomethyl-2- protein] LFML04_RS06415 / Hg 2+ RS03135 Hg 2+ adenosyltranferase] dihydroneopterin kinase: LFML04_RS00495 sulfanyl-L-cysteine bis-MGD glycosylase/ nuoE nuoH nuoI nuoK LFML04_RS04415 map map HslV: hslV 5A : bifunctional kinase: chorismate LFML04_RS01050 ACP synthase ACP synthase protein: LFML04_RS12315 thiouridine 34 in tRNA a [SoxY protein]-S-(2- synthase: dihydrolipoyl FAD synthetase: LFML04_RS12180 thiamine phosphate dihydroneopterin 5-(2-hydroxyethyl) a [glycine- DNA-(apurinic LFML04_RS04565 endolytic a peptide riboflavin kinase/ LFML04_RS05450 HMP-P II: fabF II: fabF tRNA 2- sulfodisulfanyl)-L-cysteine acpS a 1-acyl-2- a [2-oxoglutaratedehydrogenase: LFML04_RS09680 synthase: aldolase: aminodeoxychorismate/ -4-methylthiazole cleavage complex an L-1-phosphatidylethanolamine or apyrimidinic transglycosylase an N-terminal L- cobalt- FAD synthetase: (R)-4'- thiouridine(34) arachidonoyl- choline dehydrogenaselpdA a [cysteine desulfurase]- cob(I)alamin- LFML04_RS00485 LFML04_RS11475 anthranilate synthase 6 a 3-oxooctanoyl-[acp] site) : mutM MltG: mltG met threonyl-[protein] met a peptide arsenite RS11975 arsenite precorrin-5B LFML04_RS09680 NAD de novo biosynthesis hydroxymethylpyrimidine/ H protein] N -[(R a 3-oxooctanoyl-[acp] a holo-[EntF 6 phosphopantothenate sulfo-bis(guanylyl synthase + sn-glycerol E2 protein] N roseoflavin [scaffold protein- [corrinoid thiamine I (from aspartate) 6-(hydroxymethyl) component II: phosphomethylpyrimidine )-lipoyl]-L-lysine NAD menadiol 3',5'-ADP cobalt-precorrin- bifunctional molybdopterin) MnmA: mnmA L-seryl-carrier 3-phosphate -lipoyl-L-lysine adenine (2Fe-2S)] complex FMN adenosyltranferase] phosphate -7,8-dihydropterin LFML04_RS09480 kinase: LFML04_RS00495 3-oxoacyl-[acyl- 3-oxoacyl-[acyl- a [DNA]- a 5'-phospho- 2,6-diamino-4- GlcNAc-1,6- protein] 5B (C(1))- phosphopantothenoylcysteine 4-methyl-5-(2- cofactor fatty acid elongation -- saturated a 5-methylaminomethyl- oxidation 4-oxo-2-pentenal a lipid II dinucleotide cob(I)yrinic acid synthase: 2-amino-4-hydroxy-6- 4-amino-4- carrier-protein] carrier-protein] nucleotide- [DNA] hydroxy-5-(N-methyl) anhydro-MurNAc- arsenite RS11980 arsenite methyltransferase: bifunctional decarboxylase/ asp phosphooxyethyl) 34 IV (autotrophic a,c-diamide thiE hydroxymethyldihydropteridine deoxychorismate HMP-PP reductase: fabG reductase: fabG 2-thiouridine in tRNA 3'-phosphate formamidopyrimidine pentapeptide LFML04_RS12165 riboflavin kinase/ phosphopantothenate-- thiazole a [lipoyl-carrier ammonia oxidizers) adenosyltransferase: diphosphokinase: 6 a (3R)-3- an acetoacetyl-[acp] cobalt- a [co-chaperone]- FAD synthetase: cysteine ligase CoaBC: coaBC protein]-N -[(R a (3R)-3- a reduced cobO LFML04_RS12415 hydroxyoctanoyl-[acp] γ precorrin-6A [scaffold protein- LFML04_RS09680 adenosylcob(III) (R)-4'- thiamine 2-iminosuccinate thiamine phosphate NAD biosynthesis from 2-amino- )-lipoyl]-L-lysine hydroxyoctanoyl-[acp] cytochrome c554 a 7,8-dihydro- an N-formyl-L- a 2'- N-acetyl-β-D- β-D-fructofuranose an [apo BCAA L-alanyl- -D- a metal a metal (2Fe-2S)] complex phosphate (7,8-dihydropterin- a 5-methylaminomethyl- 8-oxoguanine pyruvate deoxyribonucleoside glutamyl-L-lysyl- 5-MTR-1-P RS04380 alamin-[corrinoid phosphopantothenoyl- synthase: 3-carboxymuconate semialdehyde adeninyl adenosylcobamide 3-hydroxyacyl- 3-hydroxyacyl- cytochrome c554: methionylaminoacyl- [DNA] glucosaminyl-(1 1-phosphate dehydrogenase dGDP cation cation SSQ1 FAD 6-yl)methyl 2-(S-geranyl) 6 adenosyltranferase] L-cysteine thiamine- quinolinate synthase 4-aminobenzoate LFML04_RS00485 2-amino-3- biosynthesis from ACP dehydratase ACP dehydratase LFML04_RS05730 in DNA tRNA 5'-triphosphate -> 4)-N-acetyl- E2 protein] N D-alanyl-D-alanine S-methyl-5- chaperone: diphosphate 34 a reduced adenosylcobalamin- monophosphate NadA: nadA thiamine carboxymuconate- adenosylcobinamide-GDP FabZ: fabZ thiouridine in tRNA β-D-muramate -dihydrolipoyl- thioribose-1- dnaK cob(I)yrinic acid bifunctional FabZ: fabZ cytochrome cm552 pyruvate ferredoxin fructose- dihydrolipoyl dependent cobalt- a,c-diamide phosphopantothenoylcysteine kinase: phosphate 6-semialdehyde a 3-oxoacyl-[acp] bifunctional DNA- peptide DNA L-lysine penicillin- phosphate a metal a metal a [chaperone-ATP]- dihydropteroate a (2E)-oct-2-enoyl-[acp] oxidoreductase: bisphosphate dehydrogenase: ribonucleoside- RS07105 precorrin-6B adenosyltransferase: decarboxylase/ LFML04_RS00670 quinolinate synthase: thiE adenine a (2E)-oct-2-enoyl-[acp] ubiquinol-cytochrome formamidopyrimidine deformylase: polymerase beta-N- binding : cation cation [co-chaperone]- synthase: folP biotin biosynthesis from LFML04_RS13345 aldolase: LFML04_RS06415 diphosphate cobalt-precorrin- cobO phosphopantothenate-- nicotinate-nucleotide-- a 5-methylaminomethyl- c reductase iron- glycosylase/ def III subunit acetylhexosaminidase: protein mtnA [scaffold protein- thiamine carboxylating thiamine diphosphate quinolinate 8-amino-7-oxononanoate I enoyl-ACP [+ 6 isozymes] LFML04_RS06410 dihydrolipoyl reductase: S-methyl-5- 6B (C 15 )- dimethylbenzimidazole enoyl-ACP 2-(Se-phospho) sulfur subunit: beta: dnaN nagZ 2: mrdA (2Fe-2S)] complex cysteine ligase CoaBC: coaBC diphosphate nicotinate-nucleotide 7,8- reductase: 3-oxoacyl- DNA-(apurinic peptide LFML04_RS02075 thio-D-ribulose methyltransferase adenosylcobalamin biosynthesis I (E. coli) thiamine phosphate (8S)-8-amino-7- phosphoribosyltransferase: reductase: selenouridine 34 in tRNA LFML04_RS09420 an [apo BCAAdehydrogenase: a metal a metal diphosphorylase: nadC dihydropteroate carboxylating LFML04_RS05190 [acyl-carrier- or apyrimidinic deformylase: [+ 3 isozymes] 1-phosphate RS12775 [decarboxylating]: 4'-phosphopantetheine 2-[(2R,5Z)- oxononanoate cobT LFML04_RS05190 a reduced dehydrogenaselpdA GDP cation cation SSQ1 folylpolyglutamate nicotinate- beta- protein] ubiquinol-cytochrome site) lyase: mutM acetyl-CoA CO H + def N-acetyl-D- DHAP D-glyceraldehyde L-alanyl-γ-D- thiamine- adenosylmethionine- adenine ribotide 2 6 cbiT chaperone NaMN 2-carboxy-4- nucleotide reductase: c reductase iron- ferredoxin [iron- GlcNAc muramate E2 protein] N glutamyl-L- pantetheine- synthase: monophosphate -8-amino-7- phosphate an octanoyl-[acp] an octanoyl-[acp] ketoacyl- D-ala ATPase: dnaK methylthiazol-5(2H diphosphorylase: fabG a 5-methylaminomethyl- sulfur subunit: sulfur] cluster [DNA] -lipoyl-L-lysine lysyl-D-alanine cobalt-precorrin-7 phosphate nicotinate (nicotinamide) LFML04_RS09445 kinase: oxononanoate ACP a [DNA]- a 5'-phospho- 7,8-dihydro- a metal a metal superpathway of heme b biosynthesis )-ylidene]ethyl 34 a L-methionylaminoacyl- molybdopterin biosynthesis 7,8-dihydrofolate HMP-PP LFML04_RS00670 nadC transaminase: bioA cobalamin 5 synthase 2-selenouridine LFML04_RS05195 nucleotide- 4-oxo-2-pentenal formate RS04840 a [chaperone- adenylyltransferase: from uroporphyrinogen-III nucleotide phosphate (7R,8S)- beta-ketoacyl- a (3R)-3- [DNA] 8-oxoguanine tRNA cation cation monoglutamate phosphate a 2,3,4-saturatedII: fabF in tRNA 3'-phosphate an [2Fe-2S] ADP]-[disordered- coaD adenylyltransferase: nadD NaMN diaminononanoate ACP synthase hydroxyacyl-[acyl- an oxidized cluster protein thiamine diphosphate synthase CobS: II: fabF fatty acyl-[acp] cytochrome cm552 form scaffold 3'-dephospho- uroporphyrinogen-III thiamine phosphate dethiobiotin 3-hydroxyacyl-carrier protein] ATP nicotinate adenine dinucleotide nicotinate LFML04_RS05805 protein] complex CoA synthase: synthase: Coα-[α-(adenin- ACP UDP-N-acetylmuramoyl- N-acetyl-muramoyl-(L- an N-modified a [pyruvate Nα,Nε-diacetyl-lysyl- cobalt-precorrin-8 (nicotinamide) a 3-oxodecanoyl-[acp] a 5,10- a uridine 34 hop-22(29)-ene γ γ O-ureido-L- non- dephospho- uroporphyrinogen NAD+ synthase: NAD+ synthase: LFML04_RS00485 LFML04_RS12790 9-yl)]-Coβ- dehydratase lipoprotein posttranslational modification gly SAM L-alanyl- -D- alanyl- -D-glutamyl-L- aminoacyl-[tRNA] asp dehydrogenase D-alanyl-D-alanine dADP IMP chaperonin molybdopterin- CoA kinase: decarboxylase: hemE a 7,8-dihydrofolate nucleotide adenosylcobamide FabZ: fabZ methylenetetrahydrofolate in tRNA glutamyl-meso-2,6- lysyl-D-alanyl-D-alanine) homoserine E2 protein] N 6 LFML04_RS06300 LFML04_RS06300 thiamine adenylyltransferase: 3-oxoacyl-[acyl- adenosylcobalamin- molecular synthase LFML04_RS00655 dethiobiotin 5'-phosphate a [prolipoprotein]- urea cycle diaminopimeloyl- -dihydrolipoyl- 5'/3'- cys coproporphyrinogen III phosphate 2-methyladeninyl nadD carrier-protein] dihydrolipoyl penicillin- dependent adenylyltransferase + adenosyl- D-alanine L-lysine chaperone NAD synthase: adenosylcobamide biosynthesis biotin reductase: fabG L-cysteine tRNA uridine-5- penicillin- aminoacyl-tRNA argininosuccinate dehydrogenase: binding nucleotidase MoeB: moeB coenzyme A nicotinate adenine hopene ribonucleoside- cobyrinate ATPase: dnaK cysteine desulfurase: thiE from adenosylcobinamide-GDP synthase prolipoprotein carboxymethylaminomethyl(34) binding hydrolase: synthase: LFML04_RS06415 protein SurE: surE an [Fe-S cluster dinucleotide a (3R)-3- arg transferase diphosphate LFML04_RS03125 molybdopterin- GTP oxygen-independent 5-methylbenzimidazolyl a tetrahydrofolate BioB: bioB Coα-[α-(adenin- a trans-2- diacylglyceryl synthesis enzyme MnmG: mnmG protein LFML04_RS07830 LFML04_RS11270 2: mrdA cobyrinate A,C- biosynthesis 2-methyladenine hydroxydecanoyl-[acp] enoyl-ACP HpnH: hpnH LD-carboxypeptidase: dihydrolipoyl reductase: inosine IscS subfamily synthase coproporphyrinogen adenosylcobamide biosynthesis thiamine NAD+ synthase: 7-yl)]-Coβ- a 2,3,4-saturated enoyl-[acyl- transferase: tRNA uridine-5- 2: mrdA diamide synthase: chaperone]-ATP nicotinate-nucleotide-- reductase: LFML04_RS10535 dehydrogenase: LFML04_RS02075 cysteine desulfurase: adenylyltransferase III oxidase: hemN from adenosylcobinamide-GDP phosphate LFML04_RS06300 9-mercaptodethiobiotin adenosylcobamide 3-hydroxyacyl- fatty acyl-[acp] carrier protein] LFML04_RS06920 ammonium carboxymethylaminomethyl(34) a [pyruvate LFML04_RS05850 protoporphyrinogen IX dimethylbenzimidazole ACP dehydratase LFML04_RS05190 argininosuccinate an N-modified an uncharged canavaninosuccinate dehydrogenaselpdA Nα,Nε-diacetyl- ADP LFML04_RS02340 MoeB: moeB dipyrromethane 5-methylbenzimidazole a [prolipoprotein]- synthesis GTPase MnmE: mnmE adenosyl hopane N-acetyl-muramoyl-(L- thiamine- phosphoribosyltransferase: + biotin lyase: argH met α amino acid tRNA 6 lysyl-D-alanine D-ala cob(II)yrinate an [L-cysteine a carboxy-adenylated cofactor biosynthesis NAD FabZ: fabZ S-1,2-diacyl-sn- glutamine- UDP-N-acetyl- -D- alanyl-γ-D-glutamyl- D-ala E2 protein] N (8S)-3',8-cyclo-7,8- protoporphyrinogen IX nicotinate-nucleotide-- monophosphate cobT synthase a,c-diamide desulfurase]-S- [small subunit of protoporphyrinogen dimethylbenzimidazole S-adenosyl-L- enoyl-ACP glyceryl-L-cysteine hydrolyzing D-ala muramoyl-L-alanyl- L-lysyl-D-alanine) -lipoyl-L-lysine adenosylcobalamin biosynthesis dihydroguanosine an apo-[hydroxymethylbilane kinase: BioB: bioB a (2E)-dec-2-enoyl-[acp] a 5-carboxymethylaminomethyluridine 34 γ sulfanyl-L-cysteine molybdopterin synthase] oxidase: hemG phosphoribosyltransferase: methionine salvage II 2-methyladenine reductase: carbamoyl- a 7,8-dihydrofolate -D-glutamyl-meso- from adenosylcobinamide-GDP I 5'-triphosphate synthase]-L-cysteine LFML04_RS00670 ribotide phosphate 5,6-dimethylbenzimidazole signal L-arginino- L-ornithine phosphate in tRNA 2,6-diaminopimelate cobT biotin LFML04_RS05190 succinate 5-methylbenzimidazole thiamine biosynthesis I (aerobic) enoyl-ACP peptidase synthase: SAH menaquinol-7 biosynthesis 5,6-dimethylbenzimidazole a [hydroxymethylbilane ribotide phosphate diphosphate cobalamin 5 reductase: II: lspA carB carA 38- D-glycero-D- an unstable acyl carrier nicotinate-nucleotide-- a thiocarboxylated synthase] ES intermediate protoporphyrin IX adenosylhomocysteinase: phosphate riboflavin LFML04_RS05190 a purine base quinoxaline-2- succinate carbamoyl a peptide with a a [lipoyl-carrier a uridine 2 all-trans- (R)-lipoate RecA filament- protein dimethylbenzimidazole cyclic pyranopterin cobalamin 5 LFML04_RS04275 synthase CobS: bifunctional riboflavin an (S-diacyl- carbamoyl lesion in DNA aryl-carrier protein carboxyl adenylate asp protein]-L-lysine 40 in tRNA ATP manno-heptose [small subunit of heptaprenyl 1,4-dihydroxy- a lipoprotein phosphate leader sequence DNA complex activation phosphoribosyltransferase: phosphate hydroxymethylbilane ferrochelatase: phosphate LFML04_RS05805 kinase/FAD synthetase: a decanoyl-[acyl-carrier protein] sn-glyceryl) argininosuccinate ornithine phosphate RluA family biotin 7-phosphateD-glycero- DNA molybdopterin synthase] L- Coα-[α-(2- diphosphate 2-naphthoate biotin-carboxyl carrier signal peptide an apo acyl- cobT synthase: hemC hemH synthase CobS: LFML04_RS09680 -L-cysteinyl- synthase: carbamoyltransferase: pseudouridine beta-D- repair α protein assembly bifunctional DNA- ADP-forming lipoate-- -ribazole a [hydroxymethylbilane LFML04_RS05805 methyladenin-9-yl)]-Co beta-ketoacyl- signal LFML04_RS11270 argF aspartate signal synthase: manno- protein carrier protein α α β FMN [apolipoprotein] formamidopyrimidine acyl carrier succinate--CoA ligase: protein ligase: holo-[acyl- 5'-phosphate synthase] ES intermediate protoheme Co -[ -(5- -adenosylcobamide ACP synthase a [biotin carboxyl- peptide L-citrulline carbamoyltransferase peptidase LFML04_RS12025 biotin--[acetyl-CoA- heptose-7- RecO: 3 apolipoprotein N- glycosylase/ protein: acpP LFML04_RS03945 LFML04_RS01050 carrier- methylbenzimidazolyl)]- 5'-phosphate II: fabF carrier protein]-L-lysine peptidase catalytic subunit: I: lepB tRNA carboxylase] ligase: phosphate recO cobalamin 5 hydroxymethylbilane β acyltransferase: lnt DNA-(apurinic LFML04_RS03950 a stabilized protein] molybdopterin Co -adenosylcobamide SppA: sppA LFML04_RS09305 pseudouridine(38- LFML04_RS12665 phosphate synthase: hemC demethylmenaquinol-7 biotin--[acetyl-CoA- or apyrimidinic sucC sucD D-glycero-βkinase:-D- rfaE1 RecA filament- synthase: 5'-phosphate met a 3-oxododecanoyl-[acp] an N-acyl-(S- signal a quinoxaline-2- a [lipoyl-carrier 40) synthase synthase CobS: carboxylase] ligase: sulfite oxidation III site) lyase: mutM 6 manno-heptose DNA complex acpS a [hydroxymethylbilane Coα-[α-(2- bifunctional FMNH diacyl-sn-glyceryl) peptide carboxyl-[aryl- protein]-N -[(R TruA: truA a holo acyl- LFML04_RS05805 2 LFML04_RS12665 AMP a leader sequence a peptide biotinyl-5'- 1,7-bisphosphate synthase] ES intermediate methionine 3-oxoacyl-[acyl- -L-cysteinyl- N-carbamoyl- )-lipoyl]-L-lysine a pseudouridine 38- 4 methyladenin-7-yl)]-Co demethylmenaquinone a [biotin carboxyl- peptidase carrier protein] carrier protein adenosylcobalamin folate polyglutamylation adenosyltransferase: carrier-protein] [lipoprotein] a [DNA]- phosphate succinyl-CoA adenylate cytidylyl molybdenum Coα-[α-(5- β-adenosylcobamide methyltransferase/2- 5,6-dimethylbenzimidazole carrier protein]-N SppA: sppA sulfite a 5'-phospho- a modified ADP L-aspartate 40 in tRNA 5'-phosphate hydroxymethylbilane LFML04_RS04270 reductase: fabG adenylyl-sulfate nucleotide- 4-oxo-2-pentenal cofactor sulfurylation tetrahydrofolate salvage from synthase: hemC methylbenzimidazolyl)]- methoxy-6-polyprenyl- synthase: bluB 6 -biotinyl-L-lysine [DNA] nucleobase a tetrahydrofolate β reductase subunit alpha: 3'-phosphate cytidylyl molybdenum 5,10-methenyltetrahydrofolate Co -adenosylcobamide SAM 1,4-benzoquinol a (3R)-3- a peptide a holo-[hydroxymethylbilane methylase UbiE: ubiE 5,6-dimethylbenzimidazole hydroxydodecanoyl-[acp] LFML04_RS02365 cofactor (trioxo) a 5,10- synthase] APS NADP biosynthesis menaquinol-6 biosynthesis a [ribosomal (1S,2R)-1- an N-terminal- a peptidoglycan an N-terminal- methenyltetrahydrofolate folylpolyglutamate formate-- serine 3-hydroxyacyl- a [biotin carboxyl- 37 α a mismatched adenosylcobalamin bifunctional menaquinol-7 a sulfurated coenzyme A an apo [peptidyl- an adenosine CTP -Kdo N-ethylglycine synthase: tetrahydrofolate hydroxymethyltransferase: menaquinol-8 biosynthesis ACP dehydratase carrier-protein dimer]- protein S12] ser C-(indol-3- DMAPP L-methionyl-L- dimer (S. aureus) L-methionyl-L- DNA an [MCD cofactor sulfate [sulfur carrier] 89 carrier protein] in tRNA + methylenetetrahydrofolate menaquinol-9 biosynthesis 6 L-aspartate yl)glycerol cysteinyl-[protein] alanyl-[protein] DNA NAD chaperone]-MCD LFML04_RS09445 ligase: LFML04_RS11350 demethylmenaquinol-6 FabZ: fabZ N -biotinyl-L-lysine adenylyltransferase: sat NAD(+) kinase: dehydrogenase/ tRNA processing 3-phosphate mismatch cysteine desulfurase: LFML04_RS10440 demethylmenaquinol-8 bifunctional acetyl-CoA acetyl-CoA 3-deoxy-manno- penicillin- glycine LFML04_RS09430 methenyltetrahydrofolate a (2E)-dodec-2-enoyl-[acp] sulfate holo-[acyl- tRNA (adenosine(37)-N6) type I methionyl type I methionyl repair LFML04_RS03125 a 5,10- demethylmenaquinol-9 bifunctional demethylmenaquinone carboxylase carboxylase 30S ribosomal : octulosonate binding oxidase + 10 cyclohydrolase FolD: folD a tetrahydrofolate carrier- -dimethylallyltransferase protein NADP an N - an N 10 - methylenetetrahydrofolate bifunctional methyltransferase/2- carboxyltransferase biotin a polycistronic protein S12 aminopeptidase: cytidylyltransferase: protein aminopeptidase: ThiO: thiO IscS subfamily demethylmenaquinone enoyl-ACP LFML04_RS09455 protein] MiaA: miaA MutS: mutS formyltetrahydrofolate formyltetrahydrofolate folylpolyglutamate demethylmenaquinone methoxy-6-polyprenyl- subunit beta: carboxylase tRNA precursor methylthiotransferase map kdsB 2: mrdA map a properly cysteine desulfurase: methyltransferase/2- reductase: trpB synthase: phosphoribosylglycinamide folylpolyglutamate synthase: methyltransferase/2- 1,4-benzoquinol LFML04_RS09450 subunit: accC RimO: rimO matched LFML04_RS02340 methoxy-6-polyprenyl- Metabolic Regulator Biosynthesis acpS 6 methoxy-6-polyprenyl- LFML04_RS05190 a [carboxyl-carrier N -(3-methylbut- ethylamine glyoxylate DNA base pair a [cytidylyl molybdenum formyltransferase: synthase: LFML04_RS09445 1,4-benzoquinol methylase UbiE: ubiE glyphosate D-glyceraldehyde an N-terminal L- a peptidoglycan an N-terminal L- 1,4-benzoquinol 6 2-en-1-yl)- CMP-Kdo cofactor chaperone]- LFML04_RS10340 LFML04_RS09445 a 5,10- methylase UbiE: ubiE menaquinol-6 protein dimer]-N - a [ribosomal 3-phosphate trp met cysteinyl-[protein] with D,D cross- D-ala met alanyl-[protein] methylase UbiE: ubiE trehalose biosynthesis V a dodecanoyl-[acp] degradation II 5'-deoxyadenosine an unsulfurated adenosine 37 cytidylyl molybdenum an N 10 - methylenetetrahydrofolate menaquinol-8 trehalose carboxybiotinyl-L-lysine a tRNA precursor a tRNA precursor met protein S12]-3- 3',5'-ADP a holo [peptidyl- link (S. aureus) a tetrahydrofolate menaquinol-9 trehalose biosynthesis I [sulfur carrier] in tRNA cofactor (sulfo-dioxo) formyltetrahydrofolate biosynthesis IV with a 5' with a 5' glyphosate methylsulfanyl- carrier protein] fatty acid biosynthesis 89 a glycogen D-glucopyranose beta-ketoacyl- extension and extension and a L-aspartate glycogen α initiation (type II) UDP- -D-glucose 6-phosphate α-maltose ACP synthase a long 3' trailer short 3' extension debranching protein: maltose alpha-D- glycine II: fabF 34 an apo-[LYS2 L- DNA with adenine:7,8- glutaminyl-tRNA gln Aminoacyl-tRNA Charging LFML04_RS06175 acetyl-CoA oxidase a 5,10- a 2-thiouridine a [DNA]-3'- + a 5'-phospho- an L-asparaginyl- an L-cysteinyl- a supercoiled a [protein]-L- trehalose-6- glucosyltransferase: laurate NAD coenzyme A 2-aminoadipyl- dihydro-8- α-D- a RNA-DNA hybrid biosynthesis via transamidation a maltodextrin acetyl-CoA carboxylase ThiO: thiO methylenetetrahydrofolate in tRNA hydroxyl [DNA] ATP [tRNA Asn ] [tRNA Cys ] duplex DNA methionine phosphate synthase: treS ribonuclease aPH: tRNA precursor carrier-protein] oxoguanine mismatch glucopyranose ATP- peptide- α α carboxyltransferase malto- LFML04_RS07565 , -trehalose a 3-oxotetradecanoyl-[acp] LFML04_RS10725with a short 1-phosphate dependent methionine subunit beta: (aminomethyl) ATP-dependent glu oligosyltrehalose 3' extension glyoxylate tRNA uridine-5- holo-[acyl- ribonuclease HII: DNA (S)-S-oxide 3-oxoacyl-[acyl- LFML04_RS09450 a tRNA phosphonate DNA ligase: A/G-specific adenine aminoacyl-tRNA aminoacyl-tRNA synthase: treY α,α-trehalose carboxymethylaminomethyl(34) carrier- glucose-1-phosphate LFML04_RS05330 helicase reductase carrier-protein] lauroyl-CoA malonyl-CoA precursor with LFML04_RS09185 glycosylase: hydrolase: hydrolase: 6-phosphate ribonuclease PH: synthesis enzyme MnmG: mnmG protein] adenylyltransferase: DinG: dinG MsrA: msrA a maltooligosyl- reductase: fabG a 5' extension LFML04_RS01320 LFML04_RS07830 LFML04_RS07830 a protein-L- trehalose trehalose- ACP S- LFML04_RS10725 tRNA uridine-5- synthase: glgC [+ 2 isozymes] carboxymethylaminomethyl(34) a single methionine- gln phosphatase: a (3R)-3- malonyltransferase: fabD acpS DNA a nucleoside 5'- an L-glutamyl- malto- phosphate acquisition synthesis GTPase MnmE: mnmE [DNA] NMN an apurinic site stranded DNA (S)-S-oxide otsB hydroxytetradecanoyl-[acp] AMP monophosphate Asn Cys Gln asn tRNA cys a tRNA [tRNA ] oligosyltrehalose a holo-[LYS2 L- adenine within DNA ADP-α-D-glucose Asp-tRNA(Asn) 3-hydroxyacyl- a malonyl-[acp] trehalohydrolase: α,α-trehalose a phosphate 3',5'-ADP 2-aminoadipyl- /Glu-tRNA(Gln) Asp-tRNA(Asn) ACP dehydratase a 5-aminomethyl-2- treZ monoester a 7,8-dihydrofolate carrier-protein] amidotransferase: /Glu-tRNA(Gln) FabZ: fabZ ketoacyl-ACP synthase an uncharged acid phosphatase: thiouridine 34 in tRNA α α gatB gatA gatC amidotransferase: , -trehalose III: LFML04_RS10385 tRNA LFML04_RS00780 gatB gatA gatC a (2E)-tetradec-2-enoyl-[acp] 3-oxoacyl-ACP synthase [+ 4 isozymes] phosphatidylglycerol phosphate α an N-terminal- a 5-phosphooxy- III: LFML04_RS00260 UDP-N-acetyl- -D-muramoyl- (2-hydroxyphenyl) lysine within (3R,5S)-3- biosynthesis II (non-plastidic) di-trans,octa-cis- 3-methylbutanoate coenzyme A an apo-[aryl- (R)-lipoate an acyl-CoA H O glu acetyl-CoA tRNA charging L-alanyl-γ-D-glutamyl-L- methyl 1-hydroxy- 2 a tRNA (S)-4-amino-5- L-methionyl-L- hydroxy-1- ammonium L-glutamyl- enoyl-ACP undecaprenyl phosphate carrier protein] gcv protein H [tRNA Gln ] lysyl-D-alanyl-D-alanine 6-oxocyclohex-2- oxopentanoate seryl-[protein] acetyl-CoA pyrroline-5- reductase: DHAP an acetoacetyl-[acp] LFML04_RS05190 queuosine biosynthesis I (de novo) ene-1-carboxylate carboxylase carboxylatepyrroline-5- gly a tRNA Gly phe a tRNA Phe thr a tRNA Thr arg a tRNA Arg cys a tRNA Cys trp a tRNA Trp tyr a tRNA Tyr his a tRNA His tRNA asp asp elongator tRNA Met met initiator tRNA Met met glu a tRNA glu ile a tRNA Ile acetate- lipoate-- acyl-CoA Asp-tRNA(Asn) phospho-N- holo-[acyl- glutamyl-tRNA type I methionyl biotin carboxyl carboxylate leu a tRNA Leu ser a tRNA ser a tRNA Ala ala val a tRNA Val lys a tRNA Lys pro a tRNA Pro -CoA protein ligase: thioesterase: /Glu-tRNA(Gln) Asn Gln a myristoyl-[acp] acetylmuramoyl- carrier- carrier reductase: asn tRNA gln a tRNA sn-glycerol preQ ligase: acs carboxylesterase: LFML04_RS01050 LFML04_RS13155 reductase: aminopeptidase: amidotransferase: 0 pentapeptide- protein] protein: accB proC glycine--tRNA phenylalanine-- threonine- -- cysteine-- tryptophan- tyrosine-- histidine-- aspartate- methionine- methionine- glutamate- isoleucine- 3-phosphate NADPH-dependent 7- LFML04_RS11545 LFML04_RS09655 map gatB gatA gatC beta-ketoacyl- cyano-7-deazaguanine transferase: synthase: [+ 3 isozymes] Hyp ligase: glyS tRNA ligase: pheT -tRNA leucine--tRNA ligase: serine--tRNA alanine--tRNA valine--tRNA ligase: tRNA ligase: lysine--tRNA tRNA ligase: -tRNA tRNA ligase: tRNA ligase: -tRNA -tRNA -tRNA proline--tRNA -tRNA -tRNA a [glycine-cleavage ACP synthase glycerol-3- reductase QueF: queF LFML04_RS04030 3-methylbutanoyl- acpS malonyl-CoA LFML04_RS07270 LFML04_RS00530 ligase: thrS LFML04_RS02170 ligase: serS ligase: alaS LFML04_RS05435 LFML04_RS05680 ligase: lysS LFML04_RS06285 ligase: trpS LFML04_RS06990 LFML04_RS09120 ligase: aspS ligase: metG ligase: metG ligase: proS ligase: gltX ligase: ileS acyl-CoA hydrolysis diphosphate 6 a carboxylate an N-terminal an L-glutaminyl- II: fabF phosphate 1-O- preQ AMP CoA 1-hydroxy-6- complex H protein] N an L-glutamyl- 1 Glu met L-seryl-[protein] Gln acyltransferase Carboxylate Degradation salicyl alcohol -[(R)-lipoyl]-L-lysine [tRNA ] [tRNA ] a 2,3,4-saturated undecaprenyl-diphospho-N- a holo-[aryl- oxocyclohex-2- an L-phenylalanyl- an L-tryptophanyl- an L-methionyl- an L-methionyl- an L-asparaginyl- an L-glutaminyl- a 3-oxohexadecanoyl-[acp] PlsY: plsY UMP 3',5'-ADP a glycyl-[tRNA Gly ] an L-threonyl-[tRNA Thr ] an L-leucyl-[tRNA Leu ] an L-seryl-[tRNA ser ] an L-alanyl-[tRNA Ala ] an L-valyl-[tRNA Val ] an L-arginyl-[tRNA Arg ] an L-lysyl-[tRNA Lys ] an L-cysteinyl-[tRNA Cys ] an L-tyrosyl-[tRNA Tyr ] an L-histidyl-[tRNA His ] an L-aspartyl-[tRNA asp ] an L-prolyl-[tRNA Pro ] an L-glutamyl-[tRNA Glu ] an L-isoleucyl-[tRNA Ile ] fatty acyl CoA tRNA guanosine(34) γ ene-1-carboxylate Phe Trp Met Met Asn Gln a 1-acyl-sn acyl-CoA acetylmuramoyl-L-alanyl- -D- carrier protein] [tRNA ] [tRNA ] [elongator tRNA ] [initiator tRNA ] [tRNA ] [tRNA ] transglycosylase Tgt: tgt citrate degradation 3-oxoacyl-[acyl- -glycerol 3- thioesterase: acetate glutamyl-L-lysyl- D-alanyl-D-alanine carrier-protein] phosphate LFML04_RS13155 a 7-aminomethyl-7- an acetyl-holo conversion a 2,3,4-saturated 34 reductase: fabG 1-acyl-sn-glycerol- deazaguanosine in tRNA UDP-N-acetyl-α-D- a 5'-half-tRNA a [lipoyl-carrier an N-terminal- fatty acid citrate [citrate lyase acyl- to acetyl-CoA di-trans,octa-cis- an acyl-[acyl- a ribonucleoside a [DNA]-3'- a 5'-phospho- 3-phosphate tRNA preQ1(34) S- muramoyl-L-alanyl-γ-D- molecule with protein]-N 6 -[(R) L-methionyl-L- repressor LexA a protein Tetrapyrrole Biosynthesis a (3R)-3- carrier protein] acetate undecaprenyl phosphate carrier protein] adenine a 3'-half-tRNA diphosphate hydroxyl [DNA] acyltransferase: adenosylmethionine glutamyl-L-lysyl-D-alanine a 2',3'-cyclic -dihydrolipoyl]- valyl-[protein] hydroxyhexadecanoyl-[acp] acetate- PRPP molecule with adenosylcobalamin- transcriptional endopeptidase LFML04_RS07070 ribosyltransferase- phosphate end L-lysine siroheme biosynthesis -CoA a 5'-OH end dependent ATP-dependent dihydrolipoyl repressor La: lon 3-hydroxyacyl- a 1,2-diacyl- isomerase QueA: queA peptidoglycan biosynthesis I Cell Structure Biosynthesis ligase: acs phospho-N- phosphate ribonucleoside- DNA ligase: dehydrogenase: type I methionyl LexA: lexA endopeptidase lipid IV biosynthesis (E. coli) Other Biosynthesis ACP dehydratase sn-glycerol a citryl-holo adenine lipid IV biosynthesis (P. putida) A acetylmuramoyl- acyltransferase diphosphate lpdA aminopeptidase: repressor La: lon (meso-diaminopimelate containing) A 34 acetyl-CoA 2'-5' RNA ligase: LFML04_RS09185 uroporphyrinogen-III FabZ: fabZ 3-phosphate an epoxyqueuosine in tRNA [citrate lyase acyl- PlsX: plsX phosphoribosyltransferase: reductase: map pentapeptide- LFML04_RS13630 dihydrolipoyl LexA: lexA a peptide UDP-N-acetyl- a (3R)-3- a (3R)-3- uroporphyrinogen-III Secondary Metabolite Biosynthesis Aromatic Compound Biosynthesis carrier protein] LFML04_RS12770 LFML04_RS02075 cleaved α 8-amino-7- a (2E)-hexadec-2-enoyl-[acp] transferase: a 2'- dehydrogenase: -D-glucosamine hydroxydecanoyl- UDP-N-acetyl- hydroxytetradecanoyl- UDP-N-acetyl- C-methyltransferase: a [lipoyl-carrier repressor LexA oxononanoate citryl-CoA lyase: LFML04_RS04030 deoxyribonucleoside [DNA] LFML04_RS06415 an N-terminal UDP-N-acetylglucosamine α [acp] α-D-glucosamine cobA 6 [acp] -D-glucosamine biosynthesis III methylerythritol phosphate pathway I chorismate biosynthesis I enoyl-ACP a CDP- LFML04_RS03960 acyl-carrier protein an acyl phosphate protein]-N -[(R met 1-carboxyvinyltransferase: precorrin-1 fluoroacetate and myo-inositol dipicolinate biosynthesis a ligated tRNA 5'-diphosphate L-valyl-[protein] reductase: diacylglycerol a queuosine 34 in tRNA undecaprenyl-diphospho-N )-lipoyl]-L-lysine murA acyl-ACP--UDP-N- pimelate fluorothreonine biosynthesis biosynthesis UMP AMP with a 2'-5' linkage acyl-ACP--UDP-N- uroporphyrinogen-III D-glyceraldehyde D-erythrose LFML04_RS05190 oxaloacetate -acetylmuramoyl-L-alanyl-γ- UDP-N-acetyl-α- acetylglucosamine O- 6-carboxyhexanoate- pyruvate CDP-diacylglycerol-- Detoxification acetylglucosamine O- C-methyltransferase: 3-phosphate D-glucopyranose 4-phosphate D-glutamyl-L-lysyl- D-alanine D-glucosamine- acyltransferase: lpxA -CoA ligase: 3-deoxy-7- asp glycerol-3-phosphate 3- acyltransferase: lpxA cobA 6-phosphate a palmitoyl-[acp] enolpyruvate acyl-ACP--UDP-N- LFML04_RS07290 phosphoheptulonate : phosphatidyltransferase: phenylmercury acyl-ACP--UDP-N- pimeloyl-CoA 1-deoxy-D- SAM-dependent pgsA an N-terminal- acetylglucosamine O- 3-deoxy- synthase: aroF LFML04_RS06245 6 37 acetate degradation acibenzolar- D-sedoheptulose UDP-N- acetylglucosamine O- precorrin-2 xylulose-5- chlorinase/fluorinase: 1-(3-sn- N -L-threonylcarbamoyladenosine adenosylcobinamide a purine 2-methylbutanoate coenzyme A AsbD acyl- pyruvate a phosphatidylcholine [DNA] acyltransferase: lpxA D-arabino- L-aspartyl- S-methyl 1-phosphate L-methionyl- a protein acetylmuramate acyltransferase: lpxA 8-amino-7- phosphate LFML04_RS12655 Ins(3)P phosphatidyl) -modified tRNA biosynthesis mercuriphenyl ribonucleoside carrier protein bifunctional precorrin- heptulosonate 4-phosphate glycyl-[protein] DNA ATP- dehydrogenase: oxononanoate synthase: dxs -sn-glycerol acetate 5'-triphosphate UDP-3-O-[(3R)-3- UDP-3-O-[(3R)-3- 2 dehydrogenase/ 5'-deoxy-5'-fluoroadenosine 7-phosphate polymerase dependent murB synthase: inositol aspartate- palmitate 3-phosphate thr acetate- pyruvate ferredoxin fructose- hydroxydecanoyl]- hydroxymyristoyl]-N- sirohydrochlorin 1-deoxy-D-xylulose holo-[acyl- phospholipase D: carboxylesterase: type I methionyl III subunit Clp: ala UDP-N-acetyl- LFML04_RS07295 monophosphatase: 3-dehydroquinate semialdehyde threonylcarbamoyl- -CoA oxidoreductase: bisphosphate α α acetyl-α-D-glucosamine ferrochelatase: phosphatidylglycerophosphatase adenosylcobinamide carrier- LFML04_RS01810 LFML04_RS11545 aminopeptidase: gamma/ clpX clpP -D-muramate N-acetyl- -D- (8S)-8-amino-7- 5-phosphate LFML04_RS12050 synthase: aroB AMP synthase: ligase: acs LFML04_RS13345 aldolase: UDP-3-O-[3- LFML04_RS12350 dehydrogenase: A: LFML04_RS05405 kinase: protein] map tau: dnaX glucosamine oxononanoate 1-deoxy-D-xylulose- LFML04_RS08800 [+ 6 isozymes] LFML04_RS06410 a 2'- a peptide hydroxymyristoyl] N- myo-inositol LFML04_RS12295 an L-1- (L-threonylcarbamoyl) 2+ synthase: UDP-N- glu UDP-3-O-[3- 5-phosphate 5-fluoro-5-deoxy-D- 3-dehydroquinate acetate benzene Hg LFML04_RS05795 (2S)-2- a 1,2-diacyl- deoxyribonucleoside acetylglucosamine sirohydrochlorin L-aspartate 4- phosphatidyl- adenylate adenosyl- acpS choline acibenzolar MeOH acetylmuramate-- hydroxymyristoyl] N- reductoisomerase: ribose 1-phosphate palmitoyl-CoA cobinamide methylbutanoyl- diphosphate sn-glycerol an N-terminal 5'-monophosphate glutamate deacetylase: lpxC type II 3- semialdehyde sn-glycerol tRNA (adenosine(37)-N6)- mercury(II) AMP D-erythrose L-alanine ligase: acetylglucosamine UDP-3-O-(3- sirohydrochlorin LFML04_RS10420 5-fluoro-5-deoxy- phosphate a purine CoA acetyl-CoA CO a reduced 3-phosphate DHAP met glycyl-[protein] racemase: dehydroquinate threonylcarbamoyltransferase reductase: 2 LFML04_RS04050 deacetylase: lpxC hydroxymyristoyl) chelatase: ribose 1-phosphate 4-hydroxy- ribonucleoside 3',5'-ADP a holo-[AsbD acyl- flavodoxin murI UDP-3-O-(3- dehydratase: aroQ complex ATPase subunit merA -α-D-glucosamine LFML04_RS04175 MEP isomerase: mtnA tetrahydrodipicolinate 5'-diphosphate carrier protein] UDP-N-acetyl- hydroxydecanoyl) type 1 TsaE: tsaE Aromatic Compound UDP-3-O-(3- bifunctional precorrin- 5-fluoro-5-deoxy-D- 3-dehydroshikimate synthase: Hg 0 α-D-muramoyl- D-glt -α-D-glucosamine 2-C-methyl-D- Degradation hydroxymyristoyl) 2 dehydrogenase/ ribulose 1-phosphate LFML04_RS11250 [+ 2 isozymes] L-alanine UDP-3-O-(3- 6 6 glucosamine N- erythritol 4-phosphate shikimate (2S,4S)-4- an N -L- N -(3-methylbut- RNase III mRNA (S)-4-amino-5- sirohydrochlorin 37 protocatechuate an unfolded hydroxymyristoyl) cytidylyltransferase: dehydrogenase: hydroxy-2,3,4,5- threonylcarbamoyladenine a sulfurated [sulfur carrier] 2-en-1-yl)- DL-allothreonine processing an alkylated DNA RNA (3S)-citryl-CoA carbonic acid sarcosine acyltransferase: ferrochelatase: degradation II (ortho- oxopentanoate protein UDP-N- glucosamine N- LFML04_RS06080 LFML04_RS05035 tetrahydrodipicolinate in tRNA adenosine 37 in tRNA glutamate-1- acetylmuramoyl- acyltransferase: lpxD LFML04_RS12350 cleavage pathway) UDP-2-N,3-O-bis[(3R)- 4-(cytidine 5'- Amine and Polyamine Biosynthesis arsenate semialdehyde L-alanine-- lpxD fluoroacetaldehyde shikimate DNA-3- chaperonin 3-hydroxytetradecanoyl]- diphospho)-2-C- protocatechuate detoxification serine ribonuclease PH: citryl-CoA lyase: : 2,1- D-glutamate UDP-2-N-[(3R)-3- siroheme tRNA (N6-isopentenyl ribonuclease III: methyladenine glycine oxidase GroEL: groL α-D-glucosamine methyl-D-erythritol ectoine biosynthesis II (glutaredoxin) hydroxymethyltransferase: LFML04_RS10725 LFML04_RS03960 LFML04_RS00195 aminomutase: ligase: murD hydroxydodecanoyl]- spermidine biosynthesis III : dipicolinate adenosine(37)-C2)- LFML04_RS12095 glycosylase: ThiO: thiO 4-(cytidine 5'- fluoroacetaldehyde NADPH repair (prokaryotes) LFML04_RS11350 hemL 3-O-[(3R)-3- UDP-2,3- LFML04_RS05530 3-carboxy-cis arsenate methylthiotransferase ribonuclease LFML04_RS08350 a protein diphospho)- dehydrogenase: arsenate UDP-N-acetyl- hydroxydecanoyl]- diacylglucosamine ,cis-muconate MiaB: miaB III: rnc 5-aminolevulinate meso- 2-C-methyl-D- LFML04_RS10910 asp shikimate 3- reductase ArsC: a nucleoside RNA acetyl-CoA oxaloacetate CO H O α-D-muramoyl-L- α diphosphatase LpxI: arg NADPH 2 2 diaminopimelate -D-glucosamine erythritol kinase: a DNA containing diphosphate glyoxylate methylamine 4-fluorothreonine aspartate kinase: phosphate LFML04_RS11985 6 acetaldehyde an alkylated alanyl-D-glutamate UDP-2,3- LFML04_RS05910 LFML04_RS07850 N -(3-methylbut-2-en- gly RNase III an apurinic/ LFML04_RS06245 SAM 3-phosphoshikimate 1- arsenite 5'-deoxyadenosine an unsulfurated an mRNA fragment nucleobase diacylglucosamine UDP-2,3- 2-phospho-4-(cytidine fluoroacetate arginine 1-yl)-2-(methylsulfanyl) met processing apyrimidinic site L-aspartyl- carboxyvinyltransferase: (2-carboxy- 37 [sulfur carrier] UDP-N- diphosphatase LpxI: diacylglucosamine 5'-diphospho)-2-C- decarboxylase, arsenical adenosine in tRNA mRNA 4-phosphate adenosylmethionine aroA 2,5-dihydro- acetylmuramoyl-L- LFML04_RS05910 diphosphatase: methyl-D-erythritol biosynthetic: pump-driving decarboxylase: speD 5-enolpyruvoyl- 5-oxofuran- alanyl-D-glutamate-- LFML04_RS00455 2-C-methyl-D- LFML04_RS05375 (R)-NADPHX 4 UDP-2,3- aspartate- shikimate 3- bifunctional 2-yl)-acetate ATPase: arsA an O - (+)-7-epi- 6-O-trans- 2, 6-diaminopimelate erythritol 2,4- a [protein]- carbamoyl H O a carboxylic ester methylsalicylate an L-glutamyl- semialdehyde carboxymuconolactone ala a pimeloyl-[acp] methylthymine L-ornithine 2 methoxy-mycolyl- diacylglucosamine lipid X agmatine dAdoMet phosphate ADP-dependent L-cysteine jasmonoyl-CoA Gln a protein ligase: cyclodiphosphate arsenite ATP a tRNA precursor phosphate [tRNA ] D-ala diphosphatase: preQ biosynthesis dehydrogenase: chorismate NAD(P)H-hydrate decarboxylase: in DNA Asp-tRNA(Asn) trehalose 6- LFML04_RS04020 lipid A disaccharide synthase: 0 LFML04_RS12295 LFML04_RS08885 CTP LFML04_RS00455 peptidoglycan maturation (meso-diaminopimelate containing) synthase: dehydratase/ /Glu-tRNA(Gln) phosphate proteasome synthase (LpxB): LFML04_RS06080 polyamine (4,5-dihydro- acyl-CoA trehalose- UDP-N-acetyl- D-alanine--D- L-aspartate 4- spermidine biosynthesis I aroC NAD(P)H-hydrate 8-amino-7- methylated-DNA-- ornithine carboxylesterase: carboxylesterase: amidotransferase: ATPase: arc lipid X (P. putida) LFML04_RS05920 aminopropyltransferase: 5-oxofuran- thioesterase: phosphatase: α-D-muramoyl- alanine ligase: lipid II (meso 2-C-methyl-D-erythritol- GTP semialdehyde epimerase: oxononanoate [protein]-cysteine S- CCA tRNA carbamoyltransferase: LFML04_RS11545 LFML04_RS11545 gatB gatA gatC speE chorismate 2-yl)-acetate LFML04_RS13155 an L-glutaminyl- trehalose-otsB an unfolded L-alanyl-γ-D- LFML04_RS04060 lipid A disaccharide diaminopimelate containing) 2,4-cyclodiphosphate LFML04_RS05160 synthase: methyltransferase: : argF lipid A disaccharide GTP diaminobutyrate- SAM Carbohydrate Degradation Gln trans-methoxy- synthase (LpxB): (S)-NADPHX LFML04_RS07295 LFML04_RS08320 LFML04_RS05240 [tRNA ] protein glutamyl-meso-2,6- D-alanyl-D-alanine synthase (LpxB): flavodoxin- cyclohydrolase -2-oxoglutarate N 1 -(3-aminopropyl) LFML04_RS12700 7,8- (+)-7-epi- an alcohol a carboxylate salicylate MeOH mono-mycolate diaminopimelate LFML04_RS05920 dependent I FolE: folE transaminase: ectB agmatine D-mannose degradation lipid A disaccharide dihydroneopterin adenosylmethionine bifunctional a [protein]-S- a tRNA jasmonate lipid A disaccharide a nascent peptidoglycan (E)-4-hydroxy- 3-oxoadipate (8S)-8-amino-7- a thymine in DNA L-citrulline 3'-triphosphate L-2,4- decarboxylase: speD ADP-dependent methyl-L-cysteine UDP-N- (E. coli) with (L-alanyl-γ-D-glutamyl- 3-methylbut- D-mannopyranose acyl-carrier protein containing a synthase (LpxB): 6-carboxytetrahydropterin diaminobutanoate NAD(P)H-hydrate oxononanoate acetylmuramoyl- tetraacyldisaccharide meso-2,6-diaminopimeloyl-D- 2-enyl- 6-phosphate 3' CCA end LFML04_RS12700 synthase: putrescine dAdoMet dehydratase/ mannose-1-phosphate Zn 2+ RS01790 Zn 2+ tripeptide--D-alanyl- lipid A 4'-kinase: lpxK alanyl-D-alanine) pentapeptide diphosphate diaminobutyrate D- alanine ligase: LFML04_RS00545 acetyltransferase: spermidine NAD(P)H-hydrate / disaccharide synthase: ispG 6 LFML04_RS04025 lipid IV (E. coli) 6-carboxy-5,6,7,8- ectA polyamine epimerase: mannose-6- a [2-oxoglutarate- a [protein]- an O - a 2'- a peptide with dihomo γ- all-trans- (P. putida) A penicillin-binding penicillin-binding (E)-4-hydroxy-3- a sulfurated H O chitin LFML04_RS05160 phosphate isomerase: SAM dehydrogenase methylguanine deoxyribonucleoside [DNA] an N-terminal linolenoyl-CoA 2 retinyl palmitate a protein a protein Fe 2+ Fe 2+ protein 2: mrdA protein 2: methylbut-2-en- tetrahydropterin (2S)-4-acetamido- aminopropyltransferase: [sulfur carrier] L-cysteine GTP tetraacyldisaccharide E2 protein] N 6 - in DNA 5'-triphosphate Xaa-L-proline UDP-N-acetyl- LFML04_RS04015 a mature peptidoglycan with 1-yl diphosphate 7-carboxy-7- 2-aminobutanoate speE LFML04_RS04940 RS04875 4'-kinase: lpxK NADPH octanoyl-L-lysine α-D-muramoyl- a nascent peptidoglycan (L-alanyl-γ-D-glutamyl-meso- deazaguanine F6P acyl-CoA beta-N- diguanylate cyclase: metalloprotease proteasome: Pb 2+ Pb 2+ lipid IV γ penicillin-binding ectoine synthase: methylated-DNA-- carboxylesterase: L-alanyl-γ-D- A with (L-alanyl- -D-glutamyl- DNA polymerase leucyl acetylhexosaminidase: LFML04_RS01755 TldD: tldD prcB prcA protein 2: mrdA 2,6-diaminopimeloyl-D-alanyl- 4-hydroxy- synthase: spermidine lipoyl thioesterase: chloride RS08010 chloride glutamyl-meso-2,6- di-trans,octa-cis (P. putida) meso-2,6-diaminopimeloyl- LFML04_RS01970 [protein]-cysteine S- III subunit delta: aminopeptidase: nagZ LFML04_RS11545 [+ 6 isozymes] D-alanine) pentapeptide 3-methylbut- LFML04_RS00030 synthase: methyltransferase: LFML04_RS13155 diaminopimeloyl- -undecaprenyl D-alanine) tetrapeptide a nascent peptidoglycan LFML04_RS02160 LFML04_RS00040 c-di-GMP a peptide a peptide 2-enyl 7-carboxy-7- ectoine lipA LFML04_RS08320 D-alanyl-D-alanine phosphate with D,D cross-links (meso- Pentose Phosphate Pathways [+ 5 isozymes] N-acetyl-D- LD-carboxypeptidase: 4-hydroxy- diphosphate deazaguanine Nucleoside di-homo-γ- chitin palmitate a retinol 2+ 2+ diaminopimelate containing) a peptide with glucosamine Ca RS01945 Ca 3-methylbut- reductase: 7-cyano-7- and Nucleotide a [2-oxoglutarate a proteinogenic linolenate phospho-N- LFML04_RS10535 pentose phosphate pathway 5'-deoxyadenosine an unsulfurated a [protein]-S- an N-terminal 2-enyl ispH deazaguanine gluconeogenesis I Carbohydrate Biosynthesis Degradation met dehydrogenase a guanine in DNA amino acid a nascent peptidoglycan a nascent peptidoglycan a mature peptidoglycan O-antigen building blocks biosynthesis (E. coli) α 6 [sulfur carrier] methyl-L-cysteine [DNA] acetylmuramoyl- a nascent peptidoglycan with diphosphate UDP- -D-glucose GDP-L-fucose E2 protein] N L-proline with L,D cross links (meso- with (L-alanyl-γ-D-glutamyl- with (L-alanyl-γ-D-glutamyl- synthase D-glucopyranose inosine 5'- pentapeptide- (L-alanyl-γ-D-glutamyl-meso- a mature peptidoglycan reductase: UDP-α-D- α-D- biosynthesis biosynthesis I (from -lipoyl-L-lysine diaminopimelate containing) meso-2,6-diaminopimeloyl- meso-2,6-diaminopimeloyl- QueC: queC (S)-malate D-glucopyranose 6-phosphate phosphate potassium- transferase: 2,6-diaminopimelate) tripeptide with D,D cross-links (meso- ispH galactose glucopyranose D-glucopyranose GDP-D-mannose) + + glycine) tetrapeptide D-alanine) tetrapeptide IPP 6-phosphate GDP-α-D- degradation K transporting K LFML04_RS04030 diaminopimelate containing) preQ UDP- 1-phosphate glucose-6-phosphate 6-phosphate glucose-6- α trans,octacis β 5-(methylsulfanyl) an [amino-group carrier 6-O-trans-keto- 0 glucose-1-phosphate mannose GDP- -D- ADP-L-glycero- - heptosyl- an (R)-2- a [protein] N-terminal- D-firefly ATPase malate galactopyranose isomerase: alpha-D-glucose phosphate H O γ roseoflavin a DNA segment mannose -decaprenyl D-manno-heptose Kdo -lipid A 2 -2,3-dioxopentyl protein]-C-terminal- - mycolyl-trehalose undecaprenyldiphospho- thymidylyltransferase phosphate-specific 2 halocarboxylate formyl-L-methionine luciferyl-CoA a mature peptidoglycan dehydrogenase: mutase: glf LFML04_RS04810 dehydrogenase: IMP phosphate 1-phosphate (L-glutamyl)-L-glutamate bifunctional 6-phosphate N-acetylmuramoyl-L- a mature peptidoglycan with UDP-Galf RfbA: rfbA phosphoglucomutase: GDP-4-dehydro- IMP 2,3-diketo-5- Peptide RS06630 Peptide with L,D cross-links (meso- a mature peptidoglycan mdh dTDP-α-D-glucose bifunctional zwf riboflavin kinase/ trehalose- recombinase alanyl-γ-D-glutamyl-meso (L-alanyl-γ-D-glutamyl-meso- γ LFML04_RS06430 α-D-rhamnose dehydrogenase: lipopolysaccharide acyl-CoA methylthiopentyl-1- acetylglutamate diaminopimelate containing) with (L-alanyl- -D-glutamyl- transaldolase/ glucose-6- polyprenol HAD family peptide FAD synthetase: phosphatase: RecA: recA -2,6-diaminopimeloyl- 2,6-diaminopimelate) tripeptide Polyprenyl Biosynthesis pyruvate dTDP- GDP-L-fucose guaB heptosyltransferase thioesterase: phosphate : kinase: argB meso-2,6-diaminopimeloyl- DMAPP phosoglucose phosphomannomutase/ phosphate monophosphomannose hydrolase: deformylase: def LFML04_RS09680 otsB a DNA segment D-alanyl-D-alanine oxaloacetate glucose 4,6- glycogen biosynthesis III (from α-maltose 1-phosphate) synthase: XMP II: waaF LFML04_RS13155 2-hydroxy-5-LFML04_RS10160 an [amino-group carrier trehalose- glycine) tetrapeptide isomerase: phosphoglucomutase: dehydrogenase: synthase: LFML04_RS04815 peptide roseoflavin in reverse UDP-N- di-trans,poly-cis dehydratase: LFML04_RS08580 (methylsulfanyl) protein]-C-terminal- trans-keto- LFML04_RS07905 α LFML04_RS04935 zwf LFML04_RS06105 [+ 2 isozymes] deformylase: def 5'-phosphate orientation acetylglucosamine- -undecaprenyl phosphoenolpyruvate rfbB D-glucopyranose -D-glucopyranose GDP-4-dehydro- 5'/3'- (heptosyl) - -3-oxopent-1- γ-(5-phospho-L- mono-mycolate F6P ADP-α-D-glucose 6-phospho 2 -N-acetylmuramyl- phosphate biosynthesis synthase: ppsA dTDP-4-dehydro- 6-phosphate 1-phosphate 6-deoxy-β- nucleotidase 5'-deoxyadenosine trans,octacis- Kdo -lipid A D-firefly luciferin enyl 1-phosphate glutamyl)-L-glutamate D-glucono- ADP 2 an (S)-2- an N-terminal L- (pentapeptide) (2E,6E)-farnesyl 6-deoxy-α-D- glutamine-- UTP--glucose- L-galactose SurE: surE degradation I decaprenylphospho- a halide anion formate IPP phosphoenol 1,5-lactone GDP hydroxycarboxylate methionyl-[protein] pyrophosphoryl- diphosphate glucopyranose fructose-6- 1-phosphate GDP-L-fucose β-D-mannose pyruvate 6-phosphogluconolactonase: undecaprenol N- dTDP-4- phosphate uridylyltransferase synthase: xanthosine 5'-deoxyadenosine acetylglucosamine phosphopyruvate dehydrorhamnose GalU: galU LFML04_RS08580 pgl isoprenyl hydratase: transaminase S-methyl-5'- transferase: 3,5-epimerase: rfbC D-gluconate 2251 6-O-cis-methoxy- transferase: LFML04_RS10045 (isomerizing) trehalose-6- UTP--glucose- GDP-β-L-fucose thioadenosine a [protein]- a DNA methyl an (S)-2- guanosine an L-aspartyl- (R)-2,3-dihydroxy- LFML04_RS12585 LFML04_RS10430 dTDP-4-dehydro- : glmS phosphate synthase: 1-phosphate 6-phosphate cob(II)alamin a type IV prepilin an all-trans-retinyl ester mycolyl-trehalose squalene phosphorylase: ATP L-cysteine phosphotriester halocarboxylate in 23S rRNA [tRNA Asn ] 3-methylpentanoate lipid II (meso 2-phospho- β-L-rhamnose dihydroxy-acid 6-phosphate glutamine-- LFML04_RS07565 uridylyltransferase decarboxylating 6- mtnP 23S rRNA Asp-tRNA(Asn) squalene- diaminopimelate di-trans,octa-cis D-glycerate dTDP-4- alpha-D-glucose dehydratase: trehalose- fructose-6- GalU: galU phosphogluconate xanthine (guanosine(2251) /Glu-tRNA(Gln) -hopene containing) -undecaprenyl dehydrorhamnose phosphate-specific dehydrogenase: gnd 5-deoxy-α-D- methylated-DNA-- HAD family carboxylesterase: -2'-O)- ilvD phosphatase: cyclase: phosphate α cob(I)yrinic acid amidotransferase: diphosphate reductase: rfbD phosphoglucomutase: UDP- -D-glucose ribose 1-phosphate [protein]-cysteine S- hydrolase: prepilin peptidase: LFML04_RS11545 methyltransferase [+ 2 isozymes] otsB shc transaminase D-ribulose a,c-diamide gatB gatA gatC trehalose- Amino Acid Biosynthesis undecaprenyl- dTDP-β-L- LFML04_RS06430 methyltransferase: LFML04_RS04815 LFML04_RS05065 RlmB: rlmB an L-asparaginyl- (3S)-3-methyl-2- 3-phospho- (isomerizing) 5-phosphate S-methyl-5- adenosyltransferase: 2-O- cis-methoxy- hop-22(29)-ene diphosphate rhamnose LFML04_RS08320 [+ 2 isozymes] [tRNA Asn ] oxopentanoate phosphomannomutase/ thioribose-1- 2251 mono-mycolate phosphatase: D-glycerate : glmS α,α-trehalose cobO methylguanosine L-histidine biosynthesis phosphoglucomutase: ribulose-phosphate ribose 5- urate phosphate all-trans-retinol a fatty acid L-arginine biosynthesis I (via L-ornithine) L-threonine L-leucine biosynthesis L-tryptophan biosynthesis LFML04_RS10445 phosphoglycerate D-glucosamine 6-phosphate a cleaved type in 23S rRNA L-homoserine L-cysteine LFML04_RS04935 Calvin-Benson-Bassham cycle 3-epimerase: phosphate isomerase: mtnA a [protein]-S- an (S)-2- a peptide biosynthesis di-trans,octa-cis kinase: 6-phosphate adenosylcobalamin [DNA] a halide anion IV prepilin biosynthesis biosynthesis I trehalose- LFML04_RS11520 isomerase methyl-L-cysteine hydroxycarboxylate PRPP 3-methyl-2- -undecaprenyl LFML04_RS00315 phosphoglucosamine phosphatase: 5-deoxy-D-ribulose triphosphate glu L-homoserine oxobutanoate chorismate gln phosphate GDP-mannose biosynthesis CO B: rpiB 1-phosphate ATP asp 2-isopropylmalate ser mutase: otsB D-ribulose-1,5- 2 D-xylulose synthase: 13-DPG LFML04_RS09955 ribulose 1 5- phosphoribosyltransferase: amino-acid N- aspartate kinase: homoserine kinase: serine O- D-glucopyranose α,α-trehalose bisphosphate 5-phosphate D-ribose 5- LFML04_RS12305 α-D-glucosamine bisphosphate adenine 2503 N-acetyl-D-glucosaminyl-N- an (S)-2- (-)-methyl 1,6-anhydro-N- LFML04_RS10845 acetyltransferase: LFML04_RS09590 (2S)-2- anthranilate synthase: acetyltransferase: 6-phosphate phosphate coenzyme A an adenine in DNA precorrin-6B histidinol (S)-malate LFML04_RS06245 O-phospho- type I glucose-6-phosphate 1-phosphate carboxylase in 23S rRNA acetylmuramoyl-L-alanyl-D-glutamyl- halocarboxylate VibB jasmonate acetyl-β-muramate 1-(5-phospho- LFML04_RS10300 isopropylmalate LFML04_RS09485 cysE maltose alpha-D- L-aspartyl- L-homoserine glyceraldehyde- isomerase: large subunit: transketolase: 6-carboxy-L-lysyl-D-alanine Dam family site- anhydro-N- precorrin-6y C5,15- histidinol class II β-D-ribosyl)-ATP O-acetyl-L-serine UDP-N- glucosyltransferase: DHAP bifunctional 4-phosphate 3-isopropylmalate triose- 3-phosphate LFML04_RS04810 LFML04_RS12240 LFML04_RS08590 acetaldehyde specific DNA- acetylmuramic methyltransferase dehydrogenase: fumarate : acetylglucosamine α-D- treS 23S rRNA HAD family bifunctional glutamate N- dehydratase: anthranilate PRPP phosphate dehydrogenase: bifunctional transketolase: tkt holo-[acyl- carboxylesterase: (adenine-N6)- acid kinase: (decarboxylating) hisD hydratase: aspartate- LFML04_RS04295 cysteine diphosphorylase/ glucopyranose (adenine(2503)-C(2) LD-carboxypeptidase: hydrolase: phosphoribosyl- acetyltransferase/ leuD leuC isomerase: gap transaldolase/ ADP-α-D-glucose α-maltose carrier-protein] LFML04_RS11545 methyltransferase: LFML04_RS11840 : cbiE cbiT fumC semialdehyde threonine synthase: synthase A: cysK glucosamine-1- 1-phosphate D-ribulose D-sedoheptulose D-glyceraldehyde )-methyltransferase LFML04_RS10535 LFML04_RS04815 N-acetyl-D- AMP cyclohydrolase/ amino-acid tpiA D-glyceraldehyde phosoglucose ribose 5- 3-phospho- synthase: acpS LFML04_RS03865 precorrin-8x his fumarate dehydrogenase: 2-isopropylmaleate anthranilate DHAP phosphate N- 7-phosphate 3-phosphate 6 muramate 6- phosphoribosyl-ATP acetyltransferase LFML04_RS06235 3-phosphate 5-phosphate D-glycerate RlmN: rlmN [+ 2 isozymes] an N -methyladenine LFML04_RS12295 phosphoribosyltransferase: trpD isomerase: acetyltransferase: maltokinase: phosphate UTP and CTP dephosphorylation I phosphate diphosphatase HisIE: ArgJ: argJ 3-isopropylmalate cys N-acetyl-D-glucosaminyl-N- in DNA thr LFML04_RS07905 glmU LFML04_RS03630 isomerase bifunctional 3',5'-ADP a holo-[VibB aryl- (-)-jasmonate MeOH LFML04_RS10810 L-aspartate 4- dehydratase: phosphoglycerate a 2-methyladenine 2503 acetylmuramoyl-L-alanyl-D- N-acetyl-L- F6P N-acetyl-α-D- B: rpiBD-ribose 5- transaldolase/ UTP 5'-deoxyadenosine D-ala a (2R)-2- a halide anion carrier protein] β semialdehyde N-(5-phosphoribosyl)-anthranilate α kinase: in 23S rRNA met glutamyl-6-carboxy-L-lysine 1-(5-phospho- - glutamate leuD leuC -maltose 1- ribulose-phosphate phosoglucose hydroxy fatty acid homoserine fructose- mannose-1-phosphate glucosamine phosphate LFML04_RS00315 D-ribosyl)-AMP (2R,3S)-3- phosphate 3-epimerase: isomerase: CTP synthase: dehydrogenase: phosphoribosylanthranilate bisphosphate guanylyltransferase/ 1-phosphate transketolase: bifunctional acetylglutamate isopropylmalate LFML04_RS11520 LFML04_RS07905 LFML04_RS09085 LFML04_RS06230 isomerase: LFML04_RS09465 L-alanine aldolase: mannose-6- UDP-N- alpha-1,4-glucan-- D-xylulose LFML04_RS08590 phosphoribosyl- kinase: argB 3-isopropylmalate 13-DPG UDP 5-methoxy-6- an (R)-2- a [release factor]- a guanine 37 1-(2-carboxyphenylamino)-1- biosynthesis III LFML04_RS06410 phosphate isomerase: acetylglucosamine maltose-1-phosphate 5-phosphate transketolase: tkt NaMN isobutanoate a ribonucleoside a single canavaninosuccinate propanoate DNA with lesion AMP cyclohydrolase/ dehydrogenase: maltosyltransferase: D-erythrose CTP methylbenzimidazole halocarboxylate triphosphate L-glutamine in tRNA gly N-acetylglutamyl- L-homoserine deoxy-D-ribulose 5-phosphate LFML04_RS04940 diphosphorylase/ D-sedoheptulose F6P stranded DNA peptide chain tRNA excinuclease phosphoribosyl-ATP leuB LFML04_RS03625 transketolase: glyceraldehyde- 4-phosphate acetate/propionate phosphate cys D-mannopyranose glucosamine-1- 7-phosphate release factor (guanosine(37)-N1) ABC subunit glycine diphosphatase HisIE: (2S)-2-isopropyl- indole-3-glycerol phosphate a (1->4)- LFML04_RS08590 3-phosphate family kinase: N-acetyl- cysteine desulfurase: 6-phosphate phosphate N- transketolase: UMP nicotinate-nucleotide-- acetate--CoA HAD family DNA argininosuccinate N(5)-glutamine -methyltransferase UvrB: uvrB oxidase LFML04_RS10810 3-oxosuccinate synthase TrpC: trpC β α-D-glucan dehydrogenase: LFML04_RS06350 gamma- LFML04_RS03125 -D-fructose 1,6- phosphomannomutase/ acetyltransferase: transketolase: tkt LFML04_RS08590 CDP dimethylbenzimidazole ligase: acs hydrolase: : lyase: argH methyltransferase: TrmD: trmD ThiO: thiO 1-(5-phospho-β-D-ribosyl)- gap 5'/3'- an N 1 - propanoyl [+ 2 isozymes] glutamyl- IscS subfamily bisphosphate phosphoglucomutase: glmU 1,4-alpha-glucan transketolase: tkt phosphoribosyltransferase: LFML04_RS04815 dnaG prmC DNA without 5-[(5-phosphoribosylamino) (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-sedoheptulose nucleotidase methylguanine 37 phosphate glyoxylate fructose-1,6- UDP-N-acetyl- branching enzyme: D-glyceraldehyde D-glyceraldehyde cobT [+ 2 isozymes] a [release factor]-N 5 lesion methylideneamino]imidazole- phosphate cysteine desulfurase: LFML04_RS04935 F6P 1,7-bisphosphate SurE: surE in tRNA bisphosphatase: α-D-glucosamine LFML04_RS11615 3-phosphate 3-phosphate -methyl-L-glutamine 4-carboxamide reductase: L-arginine biosynthesis II (acetyl cycle) 4-methyl-2- tryptophan synthase: LFML04_RS02340 α-D-mannose triose- CMP isobutanoyl-CoA diphosphate ssDNA/pppN(pN) L-canavanine fumarate LFML04_RS10905 uridine 5-methoxy-6- AMP 1-(5-phosphoribosyl)-5- argC oxopentanoate LFML04_RS09455 trpB ala 1-phosphate a GlgE-glycogen phosphate a (2R)-2- hybrid N-acetyl-L- fructose-1,6- 5'/3'- methylbenzimidazole nicotinate a halide anion n -1 [(5- phosphoribosylamino) N-acetylglutamyl- branched chain mannose-1-phosphate cellulose isomerase: hydroxy fatty acid glutamate 5- ser F6P bisphosphatase: nucleotidase ribotide phosphate methylideneamino]imidazole-4- amino-acid N- phosphate amino acid indole guanylyltransferase/ biosynthesis tpiA semialdehyde UDP-α-D-galactofuranose LFML04_RS10905 SurE: surE carboxamide isomerase: hisA acetyltransferase: aminotransferase: glucose-6-phosphate mannose-6- acetylornithine/ biosynthesis cellulose LFML04_RS10300 N-acetyl- Glycolysis a mature peptidoglycan a Chi-site containing an N-terminal L- 37 a [protein]- LFML04_RS02085 isomerase: phosphate isomerase: fructose- cytidine (n) a [DNA]-3'- guanine phosphoribulosylformimino- succinylornithine tryptophan synthase: cellulose synthase β H O a holo [PedD acyl- π CAIR gamma- LFML04_RS04810 PRPP biosynthesis -D-fructose 1,6- (meso-DAP containing) double stranded RecA diphosphate 2 alanyl-[S18 protein Phe N -phospho- D-ala AICAR-phosphate hydrogencarbonate family transaminase: bifunctional branched-chain LFML04_RS09455 trpB LFML04_RS04940 UDP-α-D-glucose catalytic subunit: bisphosphate DHAP hydroxyl carrier protein] in tRNA glutamate N- glutamyl- α bisphosphate aldolase: glycolysis III (from glucose) DNA with a blunt end of 30S ribosome]ribosomal protein tRNA L-histidine 5-(carboxyamino) LFML04_RS11280 amino acid bifunctional GDP- -D- UDP-glucose 4- LFML04_RS13500 D-ribose 5- ACP S- phosphohistidine glycine glutamine- acetyltransferase/ phosphate transaminase: transaldolase/ mannose LFML04_RS06410 lytic transglycosylase S18-alanine N- (guanosine(37)-N1) imidazole imidazole epimerase GalE: galE cellulose phosphate inorganic malonyltransferase: phosphatase: oxidase hydrolyzing N-acetyl-L- amino-acid reductase: LFML04_RS00635 trp phosoglucose UDP-α-D-galactose ribose-phosphate pyrimidine deoxyribonucleotides domain-containing exodeoxyribonuclease acetyltransferase: -methyltransferase ribonucleotide glycerol ornithine acetylglutamate argC D-glucopyranose exodeoxyribonuclease V: diphosphatase: III: xth fabD TrmD: trmD LFML04_RS03555 mutase: purE ThiO: thiO carbamoyl- acetyltransferase isomerase: pyrophosphokinase: dephosphorylation protein: LFML04_RS04415 an N-terminal N-acetyl-rimI a malonyl- an N 1 - phosphate kinase: argB glycine biosynthesis II UDP-galactopyranose fructose- recD LFML04_RS09865 LFML04_RS11090 a [protein]- phosphate ArgJ: argJ LFML04_RS07840 : nucleoside triphosphate 37 AIR pyruvate synthase: gln N-acetyl-L-glutamate leu LFML04_RS07905 mutase: glf bisphosphate endolytic transglycosylase L-alanyl-[S18 protein [PedD acyl- methylguanine L-histidine synthase: glu N-acetyl-L-glutamate PRPP pyrophosphohydrolase: Phe hisF hisH 5-semialdehyde a [glycine-cleavage D-glucopyranose glk MltG: mltG a [DNA]-3'- a 2'- of 30S ribosome] carrier protein] in tRNA 6 UDP-Galf aldolase: carB carA acetylornithine/ complex H protein] N - mazG a double stranded DNA deoxyribonucleoside glutamine- 6-phosphate LFML04_RS06410 D-glucopyranose dCTP dCMP with a RecA protein phosphate H + hydroxyl D-erythro-1- carbamoyl succinylornithine aminomethyldihydrolipoyl- 6-phosphate a mature peptidoglycan GlcNAc-1,6-anhMurNAc- 5'-monophosphate L-ornithine hydrolyzing bifunctional (n) loaded 3' overhang AICAR (imidazol-4- phosphate family transaminase: L-lysine (meso-DAP containing) L-Ala-γ-D-Glu-DAP-D-Ala carbamoyl- glutamate N- glycine cleavage glucose-6-phosphate yl)-glycerol LFML04_RS11280 glycine cleavage system nucleoside triphosphate phosphate acetyltransferase/ L-valine biosynthesis system protein gly isomerase: 3-phosphate ornithine synthase: aminomethyltransferase LFML04_RS04810 pyrophosphohydrolase: amino-acid GcvH: gcvH mazG a DNA containing (3E,5Z)-tetradeca- adenine 1518 / a [protein]- a [protein]- imidazoleglycerol- carbamoyltransferase: carB carA GcvT: gcvT Nucleoside and Nucleotide Biosynthesis 5-methoxybenzimidazole NaMN hydrogen selenide a holo [PedN acyl- L,L- τ a D-hexose acetyltransferase bifunctional O-acetyl-L-serine an apurinic/ 1519 N -phospho- L-tyrosine phosphate pyruvate glycine cleavage system dUTP diphosphatase: 3,5-dienoyl-CoA adenine in 16S rRNA carrier protein] diaminopimelate argF ArgJ: argJ L-proline biosynthesis [+ 2 isozymes] transaldolase/ apyrimidinic site ribosomal RNA L-histidine phosphate dehydratase carbamoyl phosphate L-ornithine biosynthetic-type aminomethyltransferase LFML04_RS01405 glucokinase: I (from L-glutamate) superpathway of guanosine phosoglucose small subunit ACP S- diaminopimelate phosphohistidine protein-tyrosine- HisB: hisB acetolactate GcvT: gcvT a [glycine-cleavage a [glycine-cleavage superpathway of inosine-5'-phosphate biosynthesis I pyrimidine deoxyribonucleotide phosphorylation dUTP dUMP nicotinate-nucleotide-- acyl-CoA glk N-acetyl-L-ornithine 6 6 5-aminoimidazole ribonucleotide biosynthesis I pyrimidine deoxyribonucleotides de novo biosynthesis III guanine and guanosine salvage cysteine malonyltransferase: epimerase: phosphatase: phosphatase: 3-(imidazol-4- synthase: ilvN ilvB complex H protein] N complex H protein] N nucleotides de novo biosynthesis I adenosine nucleotides isomerase: endonuclease III: methyltransferase asp L-citrulline dimethylbenzimidazole synthase thioesterase: A: rsmA fabD LFML04_RS00960 LFML04_RS03555 LFML04_RS12570 yl)-2-oxopropyl (S)-2-acetolactate glu -dihydrolipoyl-L-lysine -[(R)-lipoyl]-L-lysine de novo biosynthesis I dTMP dCMP LFML04_RS07905 LFML04_RS06930 N 6 -dimethyladenine 1518 a malonyl[PedN D-hexose 6- L-tyrosine AIR UDP CTP phosphoribosyltransferase: A: cysK LFML04_RS13155 meso- a [protein]- a [protein]- phosphate glutamate 5- PRPP dTMP kinase: tmk (d)CMP kinase: 5-hydroxy-CTP 5-hydroxy-CMP [+ 2 isozymes] /N 6 -dimethyladenine 1519 acyl-carrier phosphate biosynthesis I IMP 5-(carboxyamino)imidazole adenosylcobalamin- F6P cobT L-histidine L-tyrosine histidinol-phosphate argininosuccinate ketol-acid kinase: proB guanosine LFML04_RS07065 in 16S rRNA protein] diaminopimelate γ IMP dependent ribonucleoside- [+ 2 isozymes] aminotransferase: reductoisomerase: -L-glutamyl asp ribonucleotide synthase: amidophosphoribosyltransferase: dCDP (3E,5Z)- synthase: chorismate ornithine IMP diphosphate reductase: CDP dTDP acetate L-selenocysteine a 3'-terminal a 5'-phospho- coenzyme A LFML04_RS10835 L-glutamine ilvC 5-phosphate glycine cleavage system LFML04_RS06745 LFML04_RS07530 5-methoxybenzimidazole tetradecadienoate LFML04_RS11270 chorismate carbamoyltransferase: alanine dehydrogenase: N5-CAIR LFML04_RS02075 nucleoside- nucleoside- nicotinate unsaturated sugar [DNA] biosynthesis I (2R)-2,3-dihydroxy- aminomethyltransferase β adenosylcobalamin- L-histidinol mutase: aroF argF glutamate-5- racemization adenylosuccinate 5-phospho- - gly dUDP diphosphate kinase: ribotide phosphate 3-methylbutanoate GcvT: gcvT guaB dependent ribonucleoside- guanine diphosphate kinase: β-D-fructose 1,6- S-methyl-5'- C1 Compound Utilization phosphate L-arginino- prephenate semialdehyde synthase: 5-(carboxyamino)imidazole D-ribosylamine LFML04_RS07000 LFML04_RS07000 thioadenosine succinate glu dihydroxy-acid dehydrogenase: [+ 3 isozymes] nucleoside-diphosphate diphosphate reductase: bisphosphate and Assimilation ala XMP LFML04_RS10975 ribonucleotide mutase: purE degradation II β type I kinase: LFML04_RS07000 LFML04_RS02075 dTTP dCTP all-trans- N-acetyl- -D-glucosamine- a cytidine 1402 a [protein]- 6-O-cis-keto- a double argininosuccinate prephenate dehydratase: ilvD LFML04_RS00585 alanine phosphoribosylamine- hypoxanthine S-methyl-5'- formate assimilation into 5,10- 5-hydroxybenzimidazole NaMN 2-oxoglutarate ectoine a holo [BryP acyl- glutamate- [+ 2 isozymes] -glycine ligase: purD dUTP dCDP fructose- 4-hydroxybenzoate octaprenyl 1,6-anhydro-N- in 16S rRNA GGPP N-phospho- mycolyl-trehalose stranded DNA lyase: argH dehydrogenase: L-glutamate-5- racemase: CAIR phosphoribosyltransferase: hpt thioadenosine methylenetetrahydrofolate β carrier protein] -ammonia glutamine- adenylo-succinate bisphosphate S-methyl-5'- diphosphate acetyl- -D-muramate 16S rRNA phytoene synthase: L-histidine 6-phosphate LFML04_RS07055 semialdehyde alr nucleoside triphosphate nucleoside-diphosphate ACP S- phosphohistidine trehalose- DNA: histidinol 3-(4- L-citrulline ligase: glnA 3-methyl-2-oxobutanoate glycine biosynthesis I hydrolyzing GMP aldolase: thioadenosine (cytidine(1402)-2'-O) LFML04_RS10515 D-ala adenylosuccinate phosphoribosylaminoimidazolesuccinocarboxamide GAR pyrophosphohydrolase: kinase: LFML04_RS07000 formate nicotinate-nucleotide-- ectoine malonyltransferase: phosphatase: phosphatase: gyrB gyrA arg hydroxyphenyl) gln synthase: guaA GMP CMP phosphorylation LFML04_RS06410 phosphorylase: 4-hydroxybenzoate beta-N- -methyltransferase: phytoene synthase: histidinol branched chain lyase: synthase: LFML04_RS06330 mazG formate-- dimethylbenzimidazole hydroxylase: fabD LFML04_RS03555 otsB pyruvate argininosuccinate phosphoribosylglycinamide dCTP mtnP octaprenyltransferase: acetylhexosaminidase: a 2'-O- rsmI a malonyl- LFML04_RS10505 a negatively dehydrogenase: amino acid LFML04_RS06325 tetrahydrofolate phosphoribosyltransferase: thpD a [protein]- trehalose-cis-keto- synthase: ser GMP dUTP diphosphatase: LFML04_RS11300 nagZ 1402 hisD SAICAR formyltransferase: CMP triose- 5-MTR-1-P ligase: cobT methylcytidine [BryP acyl- 15-cis-phytoene L-histidine mono-mycolate supercoiled DNA LFML04_RS11270 aminotransferase: (S)-1-pyrroline- serine LFML04_RS01405 (d)CMP kinase: LFML04_RS10340 phosphate LFML04_RS10440 in 16S rRNA carrier protein] LFML04_RS02085 5-carboxylate hydroxymethyltransferase: adenylosuccinate lyase: LFML04_RS07065 an N 10 - histidinal : AMP dUMP isomerase: 4-hydroxy-3- 1,6-anhydro-N- 5-hydroxyectoine succinate L-arginino-succinate branched-chain pyrroline-5- LFML04_RS11350 LFML04_RS06325 FGAR CDP formyltetrahydrofolate 5-hydroxybenzimidazole GlcNAc tyr gly LFML04_RS07325 FAD-dependent guanine and guanosine salvage II tpiA nicotinate octaprenylbenzoate acetyl-β-muramate histidinol amino acid carboxylate D-glyceraldehyde bifunctional ribotide phosphate argininosuccinate phosphoribosylformylglycinamidine : thyX nucleoside- DHAP dehydrogenase: transaminase: reductase: : AICAR 3-phosphate methylenetetrahydrofolate lyase: argH synthase subunit PurS: purS diphosphate kinase: hisD LFML04_RS00635 proC GDP LFML04_RS07605 dTMP type I dehydrogenase/ bifunctional superpathway of pyrimidine guanosine LFML04_RS07000 α phosphoribosylformylglycinamidine glyceraldehyde- 10 1402 6-O- -mycolyl- phosphoribosylaminoimidazolecarboxamide dTMP kinase: tmk nucleobases salvage methenyltetrahydrofolate an L-methionyl- an N - lipid IV (E. coli) CMP-Kdo 2-oxobutanoate pyruvate a cytidine a holo [BryU acyl- (S)-dihydroorotate cellulose his arg val pro synthase: purQ purL CTP A glu a (6S)-5- Ins(1)P trehalose 6- ADP 3-phosphate cyclohydrolase FolD: folD [initiator tRNA Met ] formyltetrahydrofolate in 16S rRNA formyltransferase/IMP cyclohydrolase: purH [+ 2 isozymes] uracil formyltetrahydrofolate 16S rRNA carrier protein] phosphate nucleoside- adenosylcobalamin- dehydrogenase: inositol FGAM dTDP bifunctional pyr operon a 5,10- (cytosine(1402)-N(4) ACP S- dihydroorotase: trehalose- cellulase: diphosphate kinase: dependent FAICAR guanine gap 3-deoxy-D-manno- monophosphatase: adenosylcobalamin- transcriptional regulator/uracil methenyltetrahydrofolate biosynthetic-type )-methyltransferase malonyltransferase: LFML04_RS09300 phosphatase: bcsZ LFML04_RS07000 ribonucleoside- phosphoribosylformylglycinamidine nucleoside-diphosphate methionyl-tRNA octulosonic acid folylpolyglutamate LFML04_RS12050 dependent bifunctional phosphoribosyltransferase bifunctional acetolactate RsmH: rsmH fabD otsB diphosphate cyclo-ligase: LFML04_RS10345 kinase: LFML04_RS07000 13-DPG formyltransferase: transferase: synthase: an N 4 - a malonyl- α α a cellodextrin ribonucleoside- phosphoribosylaminoimidazolecarboxamide PyrR: pyrR hypoxanthine methylenetetrahydrofolate synthase: ilvN ilvB N-carbamoyl- myo-inositol , '-trehalose reductase: LFML04_RS11530 LFML04_RS05935 LFML04_RS09445 methylcytidine 1402 [BryU acyl- α diphosphate formyltransferase/IMP cyclohydrolase: purH dTTP UMP phosphoribosyltransferase: hpt phosphoglycerate dehydrogenase/ L-aspartate 6- -mycolate LFML04_RS02075 AIR in 16S rRNA carrier protein] GTP reductase: kinase: methenyltetrahydrofolate (S)-2-aceto-2- LFML04_RS02075 UMP kinase: an N-formyl- α-Kdo-(2->6)- a (6S)-5- LFML04_RS00315 cyclohydrolase FolD: folD a tetrahydrofolate CMP hydroxybutanoate IMP LFML04_RS11425 GMP L-methionyl- lipid IV (E. coli) formyltetrahydrofolate 3-phospho- a 5,10- met A dADP UDP [initiator tRNA ] dGDP D-glycerate methylenetetrahydrofolate nucleoside-diphosphate 2,3-bisphosphoglycerate- a [glycine-cleavage β nucleoside- nucleoside- kinase: LFML04_RS07000 a single orotidine 5'- an N-acetyl- - an insertion sequence a [protein]-L- a ribonucleoside dependent complex H protein] meso- Ins(2)P diphosphate kinase: diphosphate kinase: a sulfurated [sulfur carrier] SAM stranded DNA phosphate D-hexosaminide element IS30 proline (ω = 180) 5'-monophosphate UTP phosphoglycerate N 6 -octanoyl-L-lysine diaminopimelate peptidyl-prolyl cis- LFML04_RS07000 LFML04_RS07000 Amino Acid : inositol 5'/3'- mutase: trans isomerase: CTP synthase: Degradation beta-N- LFML04_RS06445 diaminopimelate monophosphatase: nucleotidase dGTP dATP LFML04_RS09085 LFML04_RS10690 exodeoxyribonuclease orotate LFML04_RS11820 lipoyl acetylhexosaminidase: [+ 2 isozymes] decarboxylase: lysA LFML04_RS12050 SurE: surE 2-phospho- L-glutamate VII: xseA xseB phosphoribosyltransferase: nagZ an insertion [+ 2 isozymes] CTP synthase: lipA a [protein]-L- D-glycerate degradation VI pyrE sequence IS30 with myo-inositol a ribonucleoside lys proline (ω = 0) phosphopyruvate (to pyruvate) an N-acetyl-β- integrated transposon a ribonucleoside a single-stranded hydratase: a [glycine-cleavage orotate an alcohol D-hexosamine glu 5'-deoxyadenosine 6 an unsulfurated oligodeoxyribonucleotide PRPP LFML04_RS10045 met complex H protein] N 5'-monophosphate -[(R)-lipoyl]-L-lysine [sulfur carrier] phosphoenol pyruvate S-methyl-5- ADP-D-glycero-β- NADH repair (prokaryotes) a [pyruvate dehydrogenase E2 a lipid II RNase R degradation methyl (indol- adenosylcobinamide acetate orotidine 5'- 6 thio-D-ribulose (2S, 3S)-3- a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine substrate RNA 3-yl)acetate D-manno-heptose phosphate methylaspartate 1-phosphate ADP- adenosylcobinamide methylthioribulose acetate/propionate orotidine-5'- pyruvate NADH glyceromanno- penicillin-binding kinase: 1-phosphate family kinase: phosphate ribonuclease carboxylesterase: LFML04_RS05795 LFML04_RS06350 heptose 6- protein 2: mrdA dehydratase: mtnB epimerase: rfaD decarboxylase: lipoyl synthase: lipA R: rnr LFML04_RS11545 5-(methylsulfanyl) β adenosyl-cobinamide acetyl phosphate ADP-L-glycero- - pyrF mesaconate phosphate -2,3-dioxopentyl D-manno-heptose UMP a N-acetylglucosamine--N- 1-phosphate a nucleoside 5'- (R)-NADHX a [pyruvate dehydrogenase D-ala acetylmuramyl-(tetrapeptide) a diribonucleotide (indol-3-yl)acetate MeOH 5'-deoxyadenosine monophosphate bifunctional met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] pyrophosphoryl-undecaprenol ADP-dependent NAD(P)H-hydrate (S)-citramalate dehydratase/ UDP-N-acetyl-α-D-muramoyl-L- a single- an electron- all-trans- D-sedoheptulose (2R,3S)-3- NAD(P)H-hydrate γ hydrogen sulfide adenosylcobinamide an acyl phosphate precorrin-4 citramalate alanyl- -D-glutamyl-meso-2,6- stranded RNA transfer quinone retinyl palmitate 7-phosphate isopropylmalate epimerase: D-sedoheptulose synthase: diaminopimeloyl-D-alanyl-D-alanine adenosylcobinamide 3-isopropylmalate precorrin-4 C(11)- LFML04_RS05160 7-phosphate acylphosphatase: (S)-NADHX LFML04_RS06250 sulfide:quinone kinase: dehydrogenase: methyltransferase: polyribonucleotide carboxylesterase: LFML04_RS05795 isomerase: LFML04_RS07160 leuB cobM penicillin-binding reductase: LFML04_RS11805 bifunctional nucleotidyltransferase: pnp LFML04_RS11545 adenosyl-cobinamide 4-methyl-2- acetate pyruvate protein 2: mrdA LFML04_RS02595 D-glycero-D-manno- a carboxylate precorrin-5 ADP-dependent phosphate oxopentanoate NAD(P)H-hydrate heptose 7-phosphate a single- dehydratase/ UDP-N-acetylmuramoyl-L- a nucleoside all-trans-retinol palmitate stranded RNA a polysulfide NAD(P)H-hydrate D-ala alanyl-γ-D-glutamyl-meso-2,6- diphosphate epimerase: L-citrulline degradation diaminopimeloyl-D-alanine LFML04_RS05160

5-amino-4- D-threo-7,8- a 3,5,7,9,11,13,15- D-arabinofuranose NADH L-citrulline dethiobiotin a sulfurated (2R,3S)-3- γ SAM imidazolecarboxyamide PRPP dihydroneopterin hepta-oxo- uroporphyrinogen-III 5-phosphate N-ethylmaleimide -carotene ornithine [sulfur carrier] isopropylmalate hexadecanoyl-[PKS-acp] uroporphyrinogen-III 3-deoxy-8- 3-isopropylmalate carotenoid carbamoyltransferase: aldo/keto reductase: alkene reductase: C-methyltransferase: phosphooctulonate dehydratase: 1,2-hydratase: argF adenine dihydroneopterin LFML04_RS05840 LFML04_RS09965 carbamoyl biotin cobA synthase: kdsA leuD leuC LFML04_RS13530 phosphoribosyltransferase: aldolase: [+ 2 isozymes] phosphate synthase 9-hydroxy-3,5,7,11,13,15- (2S)-2- 1'-hydroxy- BioB: bioB LFML04_RS12770 LFML04_RS11475 precorrin-2 KDO-8P N-ethylsuccinimide glutamine- hexaoxohexadecanoyl- isopropylmalate γ-carotene [PKS-acp] hydrolyzing 6-(hydroxymethyl) biotin 5'-deoxyadenosine an unsulfurated AICAR glycolaldehyde carbamoyl- met -7,8-dihydropterin phosphate [sulfur carrier] synthase: carB carA α (5Z,8Z,11Z,14Z,17Z) a negatively UDP-N-acetyl- -D-muramoyl- D-alanyl-D-alanine H + hydrogencarbonate uroporphyrinogen-I chlorobactene citrate precorrin-8x precorrin-3B carbamate L-alanyl-γ-D-glutamyl-L-lysine -icosapentaenoyl-CoA supercoiled DNA carotenoid precorrin-8X precorrin-3B C(17)- type I DNA uroporphyrinogen aconitate hydratase: 1,2-hydratase: methylmutase: methyltransferase: topoisomerase: UDP-N-acetylmuramoyl- acyl-CoA decarboxylase: hemE LFML04_RS03955 carbonic anhydrase: LFML04_RS13530 LFML04_RS13165 cobJ topA tripeptide--D-alanyl- LFML04_RS00195 thioesterase: CO D- alanine ligase: LFML04_RS13155 coproporphyrinogen I 1-hydroxychlorobactene D-threo-isocitrate hydrogenobyrinate precorrin-4 a relaxed DNA 2 LFML04_RS04025 CO H O (5Z,8Z,11Z,14Z,17Z) 2 2 coenzyme A UDP-N-acetyl-α-D-muramoyl-L-alanyl- -icosapentaenoate γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine L-methionine degradation I (to L-homocysteine) an L-1- an (S-diacyl-sn- phosphoenol N,N',N''- (S)-2-aceto-2- (S)-2- glyceryl)-L-cysteinyl- hydrogencarbonate porphobilinogen 1-hydroxyneurosporene rhodopin prephenate met phosphatidylethanolamine pyruvate triacetylchitotriose hydroxybutanoate hydroxyglutarate [apolipoprotein] methionine carotenoid ketol-acid carotenoid L-2- prephenate beta-N- hydroxymethylbilane 1,2-hydratase: reductoisomerase: 1,2-hydratase: hydroxyglutarate dehydratase: adenosyltransferase: synthase: hemC LFML04_RS04270 apolipoprotein N- phosphoenolpyruvate acetylhexosaminidase: LFML04_RS13530 ilvC LFML04_RS13530 oxidase: lhgO pheA SAM acyltransferase: lnt carboxylase: ppcA nagZ 1,1'-dihydroxy- (R)-2,3-dihydroxy- 3-phenyl-2- preuroporphyrinogen all-trans-lycopene 2-oxoglutarate neurosporene 3-methylpentanoate oxopropanoate a 2-acyl-1-lyso- an N-acyl-(S-diacyl- N,N'- N-acetyl-D- oxaloacetate phosphatidylethanolamine sn-glyceryl)-L- diacetylchitobiose glucosamine cysteinyl-[lipoprotein] SAH 3-methyl-2- 5,10-methylene- 2-amino-6-[1-hydroxyethyl]- an [amino-group carrier protein]-C- N,N'- a uridine 55 a double dCTP 1-hydroxyneurosporene methylglyoxal adenosylhomocysteinase: oxobutanoate tetrahydromethanopterin 7-methyl-7,8-dihydropterin terminal-γ-(L-ornithyl)-L-glutamate diacetylchitobiose in tRNA stranded DNA 2'-deoxycytidine LFML04_RS04275 2-amino-4-hydroxy-6- acetylornithine/ beta-N- carotenoid tRNA DNA/RNA glyoxalase (GloA): 5'-triphosphate 3-methyl-2-oxobutanoate hydroxymethyldihydropteridine succinylornithine acetylhexosaminidase: 1,2-hydratase: pseudouridine(55) nuclease LFML04_RS13015 deaminase: L-homocysteine hydroxymethyltransferase: diphosphokinase: family transaminase: nagZ LFML04_RS13530 synthase TruB: truB SfsA: sfsA LFML04_RS09630 N-acetyl-D- panB [1-(2-amino-7-methyl-4-oxo-LFML04_RS12415 an [amino-group carrierLFML04_RS11280 protein]- all-trans a pseudouridine 55 glucosamine a 5'-phosphooligonucleotide (R)-lactate dUTP 7,8-dihydro-3H-pteridin- C-terminal-γ-(L-glutamate 5- neurosporene in tRNA 6-yl)]ethyl diphosphate semialdehyde-2-yl)-L-glutamate 2-dehydropantoate THMPT L-proline degradation I

2,5-diamino-6-(5- pro DNA combined with exogenous DNA (S)-2,3,4,5- dCDP 3-phospho- β CTP phospho-D-ribitylamino) a cytosine in DNA GDP- -L-fucose 5-aminolevulinate proline to form a recombinational junction tetrahydrodipicolinate adenosylcobalamin- D-glycerate 2'-deoxycytidine pyrimidin-4(3H)-one crossover junction 4-hydroxy- phosphoglycerate DNA (cytosine-5-)- GDP-L-fucose dehydrogenase: bifunctional dependent ribonucleoside- porphobilinogen 5'-triphosphate endodeoxyribonuclease tetrahydrodipicolinate dehydrogenase: methyltransferase: synthase: (S)-1-pyrroline-LFML04_RS04600 diaminohydroxyphosphoribosylaminopyrimidine diphosphate reductase: synthase: hemB deaminase: deaminase/5-amino-6-(5-phosphoribosylamino) RuvC: LFML04_RS01670 reductase: LFML04_RS06640 dcm LFML04_RS08580 5-carboxylate LFML04_RS02075 GDP-4-dehydro- LFML04_RS09630 uracil reductase RibD: ribD resolution of recombinational junction LFML04_RS11245 a 5-methylcytosine 5-amino-6-(5-phospho- (2S,4S)-4-hydroxy-2,3,4,5- CDP 3-phosphooxypyruvate α-D-rhamnose porphobilinogen UTP formation of two intact strands tetrahydrodipicolinate in DNA L-glutamine D-ribitylamino)uracil L-glutamate-5- degradation I semialdehyde a double a single UDP adenosyl-cob(III) 2'-deoxycytidine cytidine phosphatidylglycerolphosphate rhodopin precorrin-2 gln (1-oleoyl, 2-palmitoyl) stranded DNA stranded DNA adenosylcobalamin- yrinate a,c-diamide nucleoside nucleoside Asp-tRNA(Asn) dependent ribonucleoside- carotenoid cobyric acid deaminase: precorrin-2 C(20)- deaminase: phosphatidylglycerophosphatase exodeoxyribonuclease V: deoxyribonuclease /Glu-tRNA(Gln) diphosphate reductase: 1,2-hydratase: synthase: LFML04_RS00825 methyltransferase: LFML04_RS00825 A: LFML04_RS05405 recD LFML04_RS09865 IV: LFML04_RS04335 amidotransferase: LFML04_RS02075 LFML04_RS13530 LFML04_RS07190 cobI glu gatB gatA gatC 2'-deoxyuridine uridine 1-oleoyl-2-palmitoyl- a 5'-phosphooligonucleotide a 5'-phosphooligonucleotide dUDP 1,1'-dihydroxy-1,1',2,2'- adenosylcobyrate precorrin-3A [+ 4 isozymes] phosphatidylglycerol tetrahydrolycopene glu

L-glutamate degradation IX (via 4-aminobutanoate)

glu glutamate decarboxylase: LFML04_RS03560 4-aminobutanoate

a reduced plastocyanin an amino an oxidized a lipopolysaccharide acid plastocyanin a polysaccharide a lipopolysaccharide

predicted ABC RS03815 RS06185 efflux transporter of RS10220 RS09540 a lipopolysaccharide

an amino a polysaccharide a lipopolysaccharide O acid 2 a lipopolysaccharide H O 2 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.