Insights Into the Evolution of Regulated Actin Dynamics Via Characterization of Primitive Gelsolin/Cofilin Proteins from Asgard Archaea
Insights into the evolution of regulated actin dynamics via characterization of primitive gelsolin/cofilin proteins from Asgard archaea Caner Akıla,b, Linh T. Tranc, Magali Orhant-Priouxd, Yohendran Baskarana, Edward Mansera,b, Laurent Blanchoind,e, and Robert C. Robinsona,c,f,1 aInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, 138673 Singapore, Singapore; bDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Singapore; cResearch Institute for Interdisciplinary Science, Okayama University, 700-8530 Okayama, Japan; dCytomorphoLab, Interdisciplinary Research Institute of Grenoble, Laboratoire de Physiologie Cellulaire & Végétale, Université Grenoble-Alpes/Commissariat à l’énergie atomique et aux énergies alternatives/CNRS/Institut national de recherche pour l’agriculture, l’alimentation et l’environnement, 38054 Grenoble, France; eCytomorphoLab, Hôpital Saint Louis, Institut Universitaire d’Hématologie, Unité mixte de recherche S1160, INSERM/Assistance publique – Hôpitaux de Paris/Université Paris Diderot, 75010 Paris, France; and fSchool of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology, 21210 Rayong, Thailand Edited by Thomas D. Pollard, Yale University, New Haven, CT, and approved July 7, 2020 (received for review May 15, 2020) Asgard archaea genomes contain potential eukaryotic-like genes gelsolin domains, while some species of Heimdallarchaeota may that provide intriguing insight for the evolution of eukaryotes. contain a distant homolog of ARP2/3 subunit 4 (1, 2, 6–8). The The eukaryotic actin polymerization/depolymerization cycle is crit- presence of these genes raises the question to what extent these ical for providing force and structure in many processes, including archaea are able to regulate their actin dynamics by this limited membrane remodeling.
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