Timings may change due to last-minute withdrawal by speakers

SUNDAY, 13 JUNE 2021: CONTINUING EDUCATION COURSES (CEC)

CEC 1: Evolving International Methodologies and Tools for Chemical Risk Assessment CEC 2: Vaccine Development in the 21st Century Welcome Remarks 09:00 – 09:10 Welcome Remarks Chair: Richard Brown, Switzerland; Mary Gulumian, South Africa 09:00 – 09:10 Chair: Alan Hoberman, Charles River Laboratories, USA Introduction to the Course 09:10 – 09:50 Introduction and History of Vaccines Mary Gulumian, NIOH, South Africa 09:10 – 09:50 Deborah Novicki, DL Novicki Toxicology Consulting LLC Overview of IPCS Methodologies and their Interrelationships 09:50 – 10:30 Non-Clinical Regulatory & Testing Considerations for Bette Meek, Uni. of Ottawa, Canada 09:50 – 10:30 Vaccine Development in 2021 10:30 – 10:50 Break David Pepperl, Biologics Consulting Update on Latest WHO/IPCS Activities on Chemical Risk 10:30 – 10:50 Break Assessment Methodologies, Including the Human Health 10:50 – 11:30 Risk Assessment Toolkit Case Studies on Regulatory Toxicology for Prophylactic 10:50 – 11:30 Vaccines for the Developing and Developed World Richard Brown, WHO, Switzerland Alex Rodriguez, GSK, Belgium Computational Toxicology in Hazard Characterization and Vaccines and Pregnancy: COVID-19 and Special Groups 11:30 – 12:10 Risk Assessment 11:30 – 12:10 Bette Meek, Uni. of Ottawa, Canada Alan Hoberman, Charles River Laboratories, USA Information Resources & Applications: Databases for 12:10 – 12:30 Question and Answer Session 12:10 – 12:50 Hazard & Predictive Application of “Omics” Data Elaine Faustman, Uni. of Washington, USA

12:50 – 13:10 Question and Answer Session 13:10 – 14:10 Break 14:10 – 17:00 Interactive Exercise

Open Monday, 14 June 2021 09:00 – 09:10 Welcome Speech & announcement of IUTOX Award and Lifetime Achievement Award winners (IUTOX President) 09:10 – 09:20 Welcome Speech (MySOT President) 09:20 – 09:30 Opening Remarks (CTDC 11 Chair) Day 1 Subtheme: Challenges and Advances in Chemical Risk Assessment Symposium 1: New Technologies & Mechanistic Data Supporting Symposium 2: A User-Friendly Tool to Assess Risks from Workshop 1: Challenges and Advances in Pesticides Risk the Future of Risk Assessment Under Real-life Risk Simulation Combined Exposures to Indoor Air Pollutants in Public Spaces of Management (Dietary & Spray Operator Risk Assessments) 09:30 – 09:40 Approach Children Chairs: Jeong Han Kim, Seoul National Uni; Budiawan, Uni. Chair: Michael Aschner, Albert Einstein Coll. Med., USA Chair: Irina Zastenskaya, WHO Europe Regional Office Experimental Studies on Real-Life Risk Simulation Supporting the Overview of the Approach to Combined Exposures in the WHO Update on Pesticides Exposure Risk Assessment for Spray 09:40 – 10:10 Shift to New Risk Assessment Approaches Screening Tool Operators in the Field Condition Anca Oana Docea, Uni. of Med & Pharm Craiova, Romania Bette Meek, Uni. of Ottawa, Canada Jeong Han Kim, Seoul National Uni Complementary and Alternative Models in Risk Assessment: What The Supporting Database: An Updated Resource of International Value of the Stewardship Practices in Minimizing the 10:10 – 10:40 Can We Learn from Worms? Guidance Values Pesticide Exposure to Spray Operators in the Field Condition Michael Aschner, Albert Einstein Coll. Med., USA Katleen De Brouwere, VITO, Belgium Yoji Hashino, Syngenta Asia Pacific Pte Ltd 10:40 – 11:00 Break The Application of Big Data and Machine Learning in Risk Exposure Assessment to Support the Screening Tool Food Safety: Dietary Risk Assessment, An Update on 11:00 – 11:30 Assessment Irina Zastenskaya, WHO Europe Regional Office Pesticides Dietary Risk Assessment Thomas Hartung, CAAT, John Hopkins Sch. Pub. Health, USA M. Nazrul Fahmi A. Rahim () & Budiawan (Indonesia) Food safety: Importance of Communication with Key Application of the Screening Tool 11:30 – 12:00 Stakeholders WITHDRAWN Tamas Szigeti, National Public Health Centre, Hungary Vasant L. Patil, CropLife, Singapore 12:00 – 12:20 Question and Answer Session Question and Answer Session Question and Answer Session 12:20 – 13:40 Break Symposium 3 Recent Development in the Public Health Oral Session 1: Ecotoxicology / Environmental Toxicology Oral Session 2: Risk Assessment 13:40 – 13:50 Management of Chemical Incidents Chair: Mohd Nazil Salleh, PICOM, Malaysia Chair: Poh Wen Tsin, NPRA, Malaysia Chair: Richard Brown, WHO, Switzerland Herbicides and Population Health of Frog, Fejervarya Occupational Exposure to Pesticides Among Rice Growers in The 2020 Update of the WHO Guidelines for Poison Control 13:50 – 14:20 Limnocharis, in Paddy Fields of Northern Thailand (OS2-O03) Malaysia (OS7-O01) Martin Wilks, Swiss CAHT, Switzerland Luhur Septiadi, Chulalongkorn Uni., Thailand Wong Hie Ling, Uni. Malaysia Kelantan, Malaysia Phthalate and Bisphenol a Mixture-Linked Asthma Development: Cellular Uptake and Biological Impacts of Copper Hydroxide Poisons Centres and Public Health Advice 14:20 – 14:50 Positive Probiotic Intervention (OS2-O02) Nanopesticides in Drosophila Melanogaster (OS7-O03) Raquel Duarte-Davidson, Public Health England, UK Katarina Baralić, Uni. of Belgrade, Serbia Eşref Demir, Antalya Bilim Uni., Turkey Microbial Enzymes from Microcystin-Degrading Bacteria for Risk Assessment of Aflatoxin in Herbal Medicines and Emergency Response Preparedness for Chemical Incidents 14:50 – 15:20 Bioremediation (OS2-O04) Food Supplements Marketed in Malaysia (OS7-O04) Haidar Rizal Toha, Johor Health Dept., MoH, Malaysia Salfarina Ramli, Uni. Technology MARA, Malaysia Siti Soleha Abdullah, Uni. Putra Malaysia 15:20 – 15:40 Break International Health Regulations and Core Capacities for Chemical Total Diet Study on Exposure to Methylmercury in Malaysia 15:40 – 16:10 Events WITHDRAWN (OS7-O05) Richard Brown, WHO, Switzerland Laila Rabaah Ahmad Suhaimi, Min. of Health, Malaysia GIS-Based Interpolation Method to Urinary Metal Identifying New and Emerging Risks from Chemicals 16:10 – 16:40 Concentrations in Malaysia (OS7-O02) Chris Weis, NIEHS, USA WITHDRAWN Noraishah Mohd Sham, Min. of Health, Malaysia 16:40 – 17:00 Question and Answer Session Question and Answer Session Question and Answer Session

Open Tuesday, 15 June 2021 09:00 – 09:10 Remarks from ASIATOX President & Introduction to Keynote Speaker Keynote. The Botanical Safety Consortium: A Public-Private Partnership to Enhance the Botanical Safety Toolkit 09:10 – 09:50 Connie Mitchell, Health & Environmental Sciences Institute, USA Day 2 Subtheme: Emerging Issues in Toxicology Symposium 5: When & How We Can Stop Using Animals in Workshop 2: Chemical Stewardship: Global Regulations and Beyond Symposium 4: Emerging Issues of Herbal Medicine Safety Toxicology Compliance in Meeting Sustainable Performance of Energy Industry 09:50 – 10:00 Chairs: Nurşen Başaran, Hacettepe Uni., Turkey; Nan Mei, FDA, Chair: Emanuela Corsini, Uni. of Milan, Italy; Chair: Hazlina Yon, DOSH, Malaysia USA Thomas Hartung, CAAT, USA Regulatory Expectations for Sustainable Chemicals Management in Unpredictable Adverse Effects of Herbal Products Applicability Domains and Future of Non-animal Tests 10:00 – 10:30 Developing Countries Nurşen Başaran, Hacettepe Uni., Turkey Nicole Kleinstreuer, NIH, USA Hazlina Yon, DOSH, Malaysia Complementary and Alternative Medicines: Malaysia Managing Trade Barrier through Application of Globally Harmonized 10:30 – 11:00 Scenario WITHDRAWN System (GHS) to Petroleum Substances Seetha Ramasamy, NPRA Jessica Ryman-Rasmussen, API 11:00 – 11:20 Break The AFSA Collaboration: Implementing Animal-Free Safety UNITAR’s Perspective on the Emerging Beyond 2020 Framework and Registration of Herbal Drugs in EMA 11:20 – 11:50 Assessment of Cosmetics Globally What it Means for the GHS and PRTRS Heidi Foth, Martin Luther Uni., Germany Catherine Willett, Human Soc International Europe Oliver Wootton, UN Inst. Training & Research; Servet Goren, Cefic Quantitative Analysis of Toxicity Data of Herbal Products The Way Forward: The Experience at CAAT Managing Environmental Health Risks in the Oil & Gas Industry 11:50 – 12:20 Nan Mei, FDA, USA Thomas Hartung, CAAT, US Nor Rahmah Nor Hashim, PETRONAS Herbal Products: Regulation and Safety Testing in Thailand. Immunotoxicology: A History of a Success 12:20 – 12:50 Rawiwan Maniratanachote, NSTDA, Thailand Emanuela Corsini, Uni. of Milan, Italy Question and Answer Session 12:50 – 13:10 Question and Answer Session Question and Answer Session

13:10 – 14:10 Break

Oral Session 3: Herbal/Natural Product Toxicology Oral Session 4: Genotoxicity Oral Session 5: Mechanistic Toxicology 14:10 – 14:20 Chair: Salfarina Ramli, UiTM Chair: Mogana Das Murtey, Uni. Sains Malaysia, Malaysia Chair: A’edah Abu Bakar, PETRONAS, Malaysia Ochratoxin A and Activities of Roasted Coffee Pharmacological Activation of Autophagy Restores Cellular Comprehensive Histone, DNA Methylation and mRNA Expression Beans in Phnom Penh, Cambodia (OS3-O01) Homeostasis in UVB-Induced Genotoxic Stress Response in Skin Analysis of Murine Liver Repeatedly Exposed to Chemicals (OS5-O02) 14:20 – 14:50 Oeung Sokunvary, Khon Kean Uni., Thailand (OS6-O02) Jun Kanno, NIEHS, Japan Sheikh Umar Ahmad, Indian Institute of Integrative Medicine, India Antioxidant Activities & Anti-inflammation of Coelonin from The Presence of Genotoxic and Carcinogenicity Fibroblast Growth Factor Receptor 4 as a Potential Druggable Target Dendrobium scabrilingue (OS3-O05) in Medicinal Based on the Malaysian Herbal Monograph for Triple Negative Breast Cancer (OS5-O03) 14:50 – 15:20 Hasseri Halim, Uni. Technology MARA, Malaysia (OS3-O02) Koh Yong Qin, National Uni., Singapore, Singapore Nur Azra M Pauzi, Uni. Putra Malaysia, Malaysia 15:20 – 15:40 Break Fish Acute Toxicity Testing of Garciae Methanolic Overview of Genotoxicity Field in Malaysian Environment (OS6- Cerium Oxide Nanoparticles a Potential Therapy for Hepatic Fibrosis 15:40 – 16:10 Extract in Adult Zebrafish (OS3-O03) O01) Symptoms (OS8-P02) Siti Zaleha Raduan, Int. Islamic Uni., Malaysia, Malaysia Mogana Das Murtey, Uni. Sains Malaysia, Malaysia Adrian Boey, National Uni. of Singapore, Singapore Toxicity Studies of Supercritical Fluid Extract of Local Reduction of Arsenic Toxicity Through Nrf2 Activation Mediated by 16:10 – 16:40 Ziziphus Mauritiana (Bidara) Fruit (OS3-O04) WITHDRAWN (2)-2-Alkenals in Coriandrum Sativum L. Leaf Extract (OS5-P01) Arnida Hani Teh, Uni., Kebangsaan Malaysia, Malaysia Hanako Aoki, Uni. of Tsukuba, Japan 16:40 – 17:00 Question and Answer Session Question and Answer Session Question and Answer Session

Open Wednesday, 16 June 2021 08:55 – 09:00 Introduction to Keynote Speaker Keynote: Global Harmonization – Togetherness for the Effective Implementation of the 3Rs of Animal Use within the Toxicity Assessments of Chemicals and Pharmaceuticals 09:00 – 09:40 Fiona Sewell, NC3Rs, UK Day 3 Subtheme: Advances in Toxicity Testing for Product Safety Symposium 6: Advance Topics in Toxicologic Pathology Symposium 7: Recent Advances in Liver Disease: from Non- Symposium 8: 3Rs Alternatives for Regulatory Testing 09:40 – 09:50 Chair: Maria Lucia Zaidan Dagli, Uni. of Sao Paulo, Brazil Alcoholic Fatty Liver Disease (NAFLD) to Fibrosis Chair: Masao Fukumura, PETRONAS, Malaysia Chair: José Manautou, Uni. of Connecticut, USA The Essential Use of Rodent Models for Toxicological Environmental Chemicals as Risk Modifiers for NAFLD Medical Devices and Non-Animal Methods for Toxicological Risk 09:50 – 10:20 Endpoints in Cancer Research Juliane Beier, Uni. of Pittsburgh, USA Assessment Maria Lucia Zaidan Dagli, Uni. of Sao Paulo, Brazil Christian Pellevoisin, Episkin, France Bridging the In Vitro and In Vivo Histopathological Evaluation Impact of Multidrug Resistance Protein 4 (Mrp4) Function on Integration of the 3Rs Alternatives in the Safety Testing for 10:20 – 10:50 for the Pharmaco Safety Assessment Hepatic Lipid Accumulation Nanotechnologies John R Foster, ToxPath Sciences Ltd., UK José Manautou, Uni. of Connecticut, USA Sasitorn Aueviriyavit, NANOTEC, Thailand 10:50 – 11:10 Break Comparative Pathology of the Toxicity of Drugs and Genetic Susceptibility to Non-Alcoholic Fatty Liver Disease: Applying Zebrafish Embryo Acute Toxicity Test in China: Status and Environmental Chemicals for Human Risk Assessment: Are Asian Genome Prospect 11:10 – 11:40 Rodents Relevant? Guruprasad Aithal, Queen’s Medical Centre, Nottingham, UK Zhenlie Huang, Southern Medical Uni, China Jerrold M. Ward, Global VetPathology, USA Inorganic Nanoparticles: Impact on Endothelial Biology Liver Current Views on the 3Rs Adaptation for the Skin Sensitization A Toxicologist’s View of Modern Safety Assessment 11:40 – 12:10 Fibrosis Testing Wolfgang Dekant, Uni. of Würzburg, Germany Ho Han Kiat, National Uni. of Singapore, Singapore Takao Ashikaga, NIEHS, Japan 12:10 – 12:30 Question and Answer Session Question and Answer Session Question and Answer Session 12:30 – 13:30 Break Forum: Women in Toxicology Oral Session 6: Nanotoxicology Oral Session 7: Occupational, Clinical or Regulatory Toxicology 13:30 – 13:40 Chair: Razinah Sharif, Uni. Kebangsaan Malaysia Chair: Siew Ee Ling, Uni. Kebangsaan Malaysia, Malaysia Chair: Ahmad Faizal Abdull Razis, Uni. Putra Malaysia Silver Nanoparticles Induced Apoptosis in Hippocampal Educational Resources for Training in Non-Animal Regulatory A Portfolio Career in Industry and Academia 13:40 – 14:10 Neurons via Mitochondrial Dysfunction (OS8-O01) Testing Methods in Developing Countries (OS8-O05) Ruth Roberts, ApconiX Chang Xiaoru, Southeast Uni., China Esther Haugabrooks, PCRM, USA Protein Corona Mitigated the Toxicity of Cadmium Telluride Exploring In Silico Toxicology from a Malaysian's Perspective: Quantum Dots to Macrophages by Targeting Mitochondria Challenges of GHS Implementation Worldwide (OS1-O02) 14:10 – 14:40 The Journey from Europe to Back Home. (OS8-O02) Goh Choo Ta, Uni. Kebangsaan Malaysia, Malaysia Rozaini Abdullah, Uni. Putra Malaysia Na Liu, Southeast Uni., China 14:40 – 15:00 Break Traditional Herbal Poisoning in Vietnam Toxicity of Curcumin Nanoparticles in Alveolar Macrophage: Microplastic Exposure, Possible Health Impact and Policy Measures 15:00 – 15:30 Uyen Vy Doan, Cho Ray Hospital, Vietnam / National Yang-Ming Effects of Surface Charges (OS8-O03) (OS1-O03) Uni., Lee Wing Hin, Uni. Kuala Lumpur, Malaysia Ahmad Faizal Abdull Razis, Uni. Putra Malaysia, Malaysia Misuse of Prescription Drugs in Singapore: An Insight from Macrophage Polarization and Inflammation Induced by Silver Safety Pharmacology Test of Plant-Based COVID-19 Vaccine in Non- 15:30 – 16:00 Public Health Specialist Nanoparticles via Autophagy in BV2 Cells (OS8-O04) Human Primates (OS1-O01) Chan Wui Ling, Singapore SOT Mengting Shang, Southeast Uni., China Suchinda Malaivijitnond, Chulalongkorn Uni., Thailand 16:00 – 16:20 Question and Answer Session Question and Answer Session Question and Answer Session 16:20 – 16:30 Closing Speech & Announcement of the venue of CTDC12 (MySOT President) 16:30 – 16:40 CTDC12 Host Presentation

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