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Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke German Institute of Human Nutrition

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Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke German Institute of Human Nutrition Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke German Institute of Human Nutrition Jahresbericht Annual Report 2003–2004 Impressum/Imprint: Herausgeber/Publisher: Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Institut der Leibniz-Gemeinschaft (WGL) Arthur-Scheunert-Allee 114-116 14558 Nuthetal http://www.dife.de Redaktion/Editors: Prof. Dr. Dr. Hans-Georg Joost Dr. Gisela Olias Dr. Lynne Rogers Redaktionsassistenz/Editorial assistant: Monika Lammersmann Gesamtherstellung: Schröders Agentur für Design · Druck · Verlag Vopeliuspfad 6 14169 Berlin Tel.: +(49)-30-80581400 Fax: +(49)-30-80581401 [email protected] www.schroeders-agentur.de Bildnachweis/Photocredits: Cover: DIfE Innenteil: DIfE; S.67, Foto: 08.06.04 Forschungszentrum Rossendorf Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Jahresbericht 2003–2004 German Institute of Human Nutrition Annual Report 2003–2004 DIfE kurzgefasst DIfE in brief Das Deutsche Institut für Ernährungsfor- The mission of the German Institute of schung Potsdam-Rehbrücke (DIfE) hat die Human Nutrition (DIfE) is to carry out Aufgabe, experimentelle und angewandte experimental and clinical research in the Forschung auf dem Gebiet Ernährung und field of nutrition and health. Its aim is to Gesundheit zu betreiben. Das Ziel ist, die understand the molecular basis of nutrition- molekularen Ursachen ernährungsbedingter dependent diseases, and to develop new Erkrankungen zu erforschen und neue Stra- strategies for prevention, treatment, and tegien für Prävention, Therapie und Ernäh- nutritional recommendations. Scientists at rungsempfehlungen zu entwickeln. Die DIfE pursue these scientific goals by inter- Grundlagen dafür werden von den am DIfE disciplinary cooperation comprising a broad tätigen Wissenschaftlern in interdisziplinärer spectrum of experimental and epidemio- Zusammenarbeit mit einem breiten natur- logical methods. A particular focus of the wissenschaftlichen, medizinischen und epi- institute is research on the most important demiologischen Methodenspektrum erarbei- diseases at present, i.e., obesity, diabetes, tet. Dabei konzentriert sich das Institut be- and cancer, whose development may sonders auf die zurzeit wichtigsten Erkran- involve nutrition-dependent factors. kungen, an deren Entstehung ernährungs- DIfE was established in 1992 by the Federal bedingte Faktoren beteiligt sein können: Republic of Germany and the State of Adipositas, Diabetes und Krebs. Brandenburg as an independent founda- Das DIfE wurde 1992 von der Bundesrepublik tion. It is a member of the Leibniz-Gemein- Deutschland und dem Land Brandenburg schaft, an alliance of scientific institutions. als selbstständige Stiftung des öffentlichen DIfE originated from the Zentralinstitut für Rechts gegründet und ist Mitglied der Ernährung der Akademie der Wissenschaften Leibniz-Gemeinschaft. Hervorgegangen ist of the German Democratic Republic, das DIfE aus dem Zentralinstitut für Ernäh- which was derived from the Institut für rung der Akademie der Wissenschaften der Ernährungs- und Verpflegungswissen- DDR, das seinen Ursprung in dem 1946 in schaften, where nutrition research had Rehbrücke gegründeten Institut für Ernäh- started in 1946. rungs- und Verpflegungswissenschaften hat. The academic members of the DIfE have Mitarbeiter des DIfE übernehmen Lehrver- teaching obligations in nutritional sciences pflichtungen im Studiengang Ernährungs- at the Universität Potsdam and in medicine wissenschaften an der Universität Potsdam at the Freie Universität Berlin. und im Studiengang Medizin an der Freien Universität Berlin. Vorwort 2 Preface In 2003, DIfE entered its second decade Mit dem Jahr 2003 begann das DIfE das after having its establishment in 1992. zweite Jahrzehnt seines Bestehens nach der Within this twelve-year period, the institute Neugründung im Jahre 1992. In zwölf Jahren has gained a reputation as a national ist es dem DIfE gelungen, sich als nationales center of competence in the field of Kompetenzzentrum auf dem Gebiet der nutrition research. Our scientists investigate Ernährungsforschung zu etablieren. Die the relationship between nutrition and Wissenschaftler des DIfE untersuchen die health by a combination of molecular, Zusammenhänge zwischen Ernährung und clinical, and epidemiological research which Krankheitsentstehung in einer für Deutsch- is unique in Germany. land einzigartigen Kombination von mole- During 2003 and 2004, DIfE has substantially kularer, klinischer und epidemiologischer focused its research profile. It now Ernährungsforschung. Damit legen sie die concentrates on the most important Grundlagen für wissenschaftlich basierte diseases in which nutrition plays a Ernährungsempfehlungen. preventive role: the metabolic syndrome as Im Berichtszeitraum hat das DIfE sein well as cancer. DIfE members published Forschungsprofil deutlich fokussiert. Es several important papers in these research konzentriert sich nun auf die zurzeit wich- areas (see page 4). In addition, DIfE will tigsten ernährungsassoziierten Krankheiten, strengthen its expertise by establishing a insbesondere das Metabolische Syndrom Prof. Dr. Dr. Hans-Georg Joost professorship and a department “Human sowie die Rolle der Ernährung in der Krebs- Nutrigenomics”, in cooperation with the entstehung. Mitarbeiter des DIfE veröffent- Potsdam University. lichten 2003 und 2004 mehrere wegwei- vom Bundesministerium für Bildung und Many questions in the field of nutritional sende Publikationen auf diesen Gebieten Forschung (BMBF) geförderten nationalen research cannot be answered by a single (s. Bericht auf S. 4). Das DIfE wird sich zudem Genomforschungs-Netzwerks (NGFN2). institute. In order to meet the challenging durch Einrichtung einer Abteilung Humane Leider wirken sich die finanziellen Probleme demands in this field, DIfE has joined Nutrigenomik verstärken, die Leitungs- von Bund und Land auch auf die Arbeit des forces with other European research position ist als gemeinsame Berufung mit DIfE aus. Die Personal- und Sachmittelkosten institutes, and has initiated two networks der Universität Potsdam ausgeschrieben. steigen stärker als unser Etat. Durch Dritt- of excellence that are sponsored by the Viele der heutigen Fragestellungen auf dem mittel-Einwerbung konnte dies bislang zum European Union (NUGONET and EUGENE2). Gebiet der Ernährungsforschung können Teil, aber nicht völlig kompensiert werden, so DIfE also carries out two projects within the nicht mehr von einem einzelnen Institut dass das Institut erstmals nicht alle Stellen national network on genome research allein bearbeitet werden. Um den gestiege- besetzen kann. (NGFN2) sponsored by BMBF (national nen Anforderungen gewachsen zu sein, hat Der Vorstand möchte allen Mitarbeiterinnen ministry of education and research). das DIfE deshalb seine Aktivitäten mit denen und Mitarbeitern des DIfE herzlich für ihre Unfortunately, our scientific work is anderer europäischer Forschungsinstitute Arbeit danken. Ebenso gilt unser herzlicher affected by the poor financial situation vernetzt und sich zwei von der Europäischen Dank allen Freunden und Förderern aus in the public sector. Expenditures for Union geförderten Kompetenz-Netzwerken Wissenschaft, Politik und Wirtschaft. Wir personnel and consumables are rising to angeschlossen (NUGONET und EUGENE2). brauchen Ihre Unterstützung auch bei der an extent that exceeds our budget. With Es ist zudem mit zwei Projekten Mitglied des zukünftigen Entwicklung des Instituts! external funding, we have been able to compensate this deficit in part, but not entirely. Thus, for the first time the institute had to reduce its staff. The board of directors wishes to thank all members of the institute for their committed work. We also thank all friends and sponsors from science, politics and industry. We need your continuous support for the future development of the institute! Prof. Dr. Dr. Hans-Georg Joost Scientific Director Dr. Hartmut Schulz Administrative Director Prof. Dr. Dr. Hans-Georg Joost Dr. Hartmut Schulz Wissenschaftlicher Direktor Administrativer Direktor Inhaltsverzeichnis 3 Content Vorwort ................................................................................................................................................. 2 Preface Ernährungsforschung am DIfE 2003–2004 ........................................................................... 4 Nutritional Research at DIfE 2003–2004 Prof. Dr. Dr. Hans-Georg Joost Abteilung Molekulare Genetik (MOGE) ................................................................................... 8 Department of Molecular Genetics Leitung: Prof. Dr. Wolfgang Meyerhof Abteilung Pharmakologie (PHA) ................................................................................................. 13 Department of Pharmacology Leitung: Prof. Dr. Dr. Hans-Georg Joost Arbeitsgruppe Physiologie des Energiestoffwechsels (EST) ............................................ 18 Laboratory of Physiology of Energy Leitung: Prof. Dr. Susanne Klaus Metabolism Abteilung Klinische Ernährung (KLE) ........................................................................................ 22 Department of Clinical Nutrition Leitung: Prof. Dr. Andreas F. H. Pfeiffer Abteilung Interventionsstudien (IVS) ....................................................................................... 27 Department of Intervention Studies Leitung: Prof. Dr. Hans-Joachim F. Zunft Abteilung Epidemiologie (EPI) ....................................................................................................
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